Page last updated: 2024-09-04

combivir and efavirenz

combivir has been researched along with efavirenz in 22 studies

Compound Research Comparison

Studies
(combivir)
Trials
(combivir)
Recent Studies (post-2010)
(combivir)
Studies
(efavirenz)
Trials
(efavirenz)
Recent Studies (post-2010) (efavirenz)
12232593,1106311,611

Protein Interaction Comparison

ProteinTaxonomycombivir (IC50)efavirenz (IC50)
Chain A, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain A, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain B, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain A, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain B, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain A, Pol PolyproteinHuman immunodeficiency virus 10.2612
Chain B, Pol PolyproteinHuman immunodeficiency virus 10.2612
Prothrombin Bos taurus (cattle)0.022
Gag-Pol polyproteinHIV-1 M:B_HXB2R0.1852
Gag-Pol polyproteinHuman immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)0.02
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.018
Microsomal triglyceride transfer protein large subunitHomo sapiens (human)0.054
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)0.004
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 Human immunodeficiency virus 10.0035
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.1627
Reverse transcriptase Human immunodeficiency virus 10.0643

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (22.73)29.6817
2010's13 (59.09)24.3611
2020's4 (18.18)2.80

Authors

AuthorsStudies
Chemlal, K; de Truchis, P; Devidas, A; Force, G; Mamet, JP; Mechali, D; Praindhui, D; Pulik, M; Rouveix, E; Welker, Y1
Gazzard, BG; Gotch, F; Hand, J; Imami, N; Nelson, M; Pires, A; Portsmouth, S; Stebbing, J1
Cooper, V; Fisher, M; Gellaitry, G; Horne, R; Lange, AC; Vrijens, B; White, D1
Alvarez, SM; de Jesús Asencio Montiel, I; Flores, RA; Martínez, JG; Mata Marín, JA1
Cooper, V; Ewan, J; Fisher, M; Horne, R; Liu, HC; Moyle, GJ; Reilly, G1
Arasteh, K; Boven, K; Crauwels, H; De Wet, J; Gathe, J; Gold, J; Hodder, S; Kumar, P; Mohapi, L; Short, W; Vanveggel, S1
Arribas, J; Deckx, H; Duiculescu, D; Florence, E; Hung, CC; Sension, M; Stevens, M; Tebas, P; Vanveggel, S; Wilkin, T1
Amaral, E; Bahamondes, L; Bahamondes, MV; Brito, MB; Duarte, G; Ferriani, RA; Prandini, TR; Quintana, SM; Ragazini, CS; Vieira, CS1
Kondapi, AK; Kumar, P; Lakshmi, YS1
Badal-Faesen, S; Brown, TT; Campbell, TB; Cardoso, SW; Erlandson, KM; Fiorillo, SP; Hakim, J; Kumarasamy, N; Kumwenda, J; Lalloo, U; Riviere, C; Sanchez, J1
Andolina, A; Carbone, A; Castagna, A; Franzin, M; Galizzi, N; Galli, L; Gianotti, N; Lazzarin, A; Merli, M; Muccini, C; Oltolini, C; Poli, A; Spagnuolo, V; Tadini, P1
Ahmadi, NE; Ahsani-Nasab, S; Bayanolhagh, S; Esmaeilzadeh, A; Lolaie, M; Moallemi, S; Mohraz, M; Narouei, A; Sadeghi, L; SeyedAlinaghi, S; Tabatabai, RA1
Castelnuovo, B; Gonza, P; Kambugu, A; Kiragga, AN; Mbabazi, O; Mubiru, F; Musomba, R; Ratanshi, RP1
Bourrel, R; Lapeyre-Mestre, M; Montastruc, JL; Rwagitinywa, J; Sommet, A1
Adebisi, SA; Adedeji, NO; Adedeji, TA1
Chen, IT; Chen, JK; Chen, YS; Lee, SS; Sy, CL; Tsai, HC; Tseng, YT; Weng, YW; Wu, KS1
Chadwick, EG; Correia, KF; Crowell, CS; DiPerna, A; Hazra, R; Seage, GR; Smith, R; Van Dyke, RB; Williams, PL; Yildirim, C1
George, PE; Mercedes, R; Nabukeera-Barungi, N; Otto, SBJ1
Abdool Karim, Q; Dawood, H; Mansoor, LE; Matten, D; Naicker, CL; Naidoo, K; Singo, D; Williamson, C1

Trials

9 trial(s) available for combivir and efavirenz

ArticleYear
Efficacy and safety of a quadruple combination Combivir + abacavir + efavirenz regimen in antiretroviral treatment-naive HIV-1-infected adults: La Francilienne.
    Journal of acquired immune deficiency syndromes (1999), 2002, Oct-01, Volume: 31, Issue:2

    Topics: Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; France; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Male; Middle Aged; Oxazines; Pilot Projects; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Viral Load; Zidovudine

2002
144-week data released on Gilead's study 934.
    AIDS patient care and STDs, 2007, Volume: 21, Issue:8

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Time Factors; Viral Load; Zidovudine

2007
96-Week MERIT ES analysis shows efficacy of Celsentri=Selzentry.
    AIDS patient care and STDs, 2009, Volume: 23, Issue:8

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; CCR5 Receptor Antagonists; CD4 Lymphocyte Count; Cyclohexanes; Cyclopropanes; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; HIV Fusion Inhibitors; HIV Infections; HIV-1; Humans; Lamivudine; Maraviroc; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Triazoles; Zidovudine

2009
The impact of once-nightly versus twice-daily dosing and baseline beliefs about HAART on adherence to efavirenz-based HAART over 48 weeks: the NOCTE study.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 53, Issue:3

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Culture; Cyclopropanes; Didanosine; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Surveys and Questionnaires; Zidovudine

2010
Beliefs about antiretroviral therapy, treatment adherence and quality of life in a 48-week randomised study of continuation of zidovudine/lamivudine or switch to tenofovir DF/emtricitabine, each with efavirenz.
    AIDS care, 2011, Volume: 23, Issue:6

    Topics: Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Substitution; Drug Therapy, Combination; Emtricitabine; Female; Health Knowledge, Attitudes, Practice; HIV Infections; HIV-1; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Organophosphonates; Quality of Life; Tenofovir; Treatment Outcome; Young Adult; Zidovudine

2011
Effect of gender and race on the week 48 findings in treatment-naïve, HIV-1-infected patients enrolled in the randomized, phase III trials ECHO and THRIVE.
    HIV medicine, 2012, Volume: 13, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Black or African American; CD4 Lymphocyte Count; Cyclopropanes; Dideoxynucleosides; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Sex Factors; Tenofovir; Treatment Outcome; Viral Load; Zidovudine

2012
Lipid levels and changes in body fat distribution in treatment-naive, HIV-1-Infected adults treated with rilpivirine or Efavirenz for 96 weeks in the ECHO and THRIVE trials.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Aug-01, Volume: 59, Issue:3

    Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Aged, 80 and over; Alkynes; Anti-HIV Agents; Benzoxazines; Body Fat Distribution; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Young Adult; Zidovudine

2014
Bleeding patterns of HIV-infected women using an etonogestrel-releasing contraceptive implant and efavirenz-based or lopinavir/ritonavir-based antiretroviral therapy.
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2016, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Alkynes; Amenorrhea; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Desogestrel; Drug Combinations; Drug Implants; Drug Interactions; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Metrorrhagia; Prospective Studies; Ritonavir; Young Adult; Zidovudine

2016
Insulin-Like Growth Factor Is Associated with Changes in Body Composition with Antiretroviral Therapy Initiation.
    AIDS research and human retroviruses, 2017, Volume: 33, Issue:9

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Body Composition; Cyclopropanes; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Insulin-Like Growth Factor I; Lamivudine; Male; Prospective Studies; Tenofovir; Zidovudine

2017

Other Studies

13 other study(ies) available for combivir and efavirenz

ArticleYear
AIDS drug in halted trial less effective as monotherapy.
    The AIDS reader, 2003, Volume: 13, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; Humans; Lamivudine; Oxazines; Viral Load; Zidovudine

2003
Treatment of primary HIV-1 infection with nonnucleoside reverse transcriptase inhibitor-based therapy is effective and well tolerated.
    HIV medicine, 2004, Volume: 5, Issue:1

    Topics: Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4-CD8 Ratio; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Flow Cytometry; HIV Infections; HIV-1; Humans; Lamivudine; Lymphocyte Activation; Lymphocyte Subsets; Male; Middle Aged; Oxazines; Reverse Transcriptase Inhibitors; Viral Load; Zidovudine

2004
Aminotransferase serum levels decrease after initiating antiretroviral treatment in HIV infected patients.
    Current HIV research, 2011, Volume: 9, Issue:1

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Longitudinal Studies; Lopinavir; Male; Pyrimidinones; Ritonavir; Serum; Transaminases; Zidovudine

2011
Triple Drug Combination of Zidovudine, Efavirenz and Lamivudine Loaded Lactoferrin Nanoparticles: an Effective Nano First-Line Regimen for HIV Therapy.
    Pharmaceutical research, 2017, Volume: 34, Issue:2

    Topics: Alkynes; Animals; Anti-Retroviral Agents; Benzoxazines; Cell Line, Tumor; Cyclopropanes; Drug Combinations; Female; Half-Life; HIV Infections; HIV-1; Humans; Lactoferrin; Lamivudine; Male; Nanoparticles; Rats; Rats, Wistar; Tissue Distribution; Zidovudine

2017
Efficacy and safety of switching from branded to generic antiretrovirals in virologically suppressed HIV-infected patients.
    PloS one, 2017, Volume: 12, Issue:8

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cohort Studies; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; Drugs, Generic; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Patient Safety; Poisson Distribution; RNA, Viral; Treatment Outcome; Zidovudine

2017
Different Degrees of Immune Recovery Using Antiretroviral Regimens with Vonavir or Zidovudine/Lamivudine/Efavirenz in HIVPositive Patients Receiving First Line Treatment in Iran.
    Infectious disorders drug targets, 2018, Volume: 18, Issue:3

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cohort Studies; Cyclopropanes; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Immunity, Cellular; Iran; Lamivudine; Male; Retrospective Studies; Reverse Transcriptase Inhibitors; Sex Factors; Time Factors; Zidovudine

2018
Antiretroviral treatment Long-Term (ALT) cohort: a prospective cohort of 10 years of ART-experienced patients in Uganda.
    BMJ open, 2018, 02-21, Volume: 8, Issue:2

    Topics: Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Combinations; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Male; Nevirapine; Prospective Studies; RNA, Viral; Time; Uganda; Viral Load; Zidovudine

2018
Comparison of adherence to generic multi-tablet regimens vs. brand multi-tablet and brand single-tablet regimens likely to incorporate generic antiretroviral drugs by breaking or not fixed-dose combinations in HIV-infected patients.
    Fundamental & clinical pharmacology, 2018, Volume: 32, Issue:4

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Combinations; Drugs, Generic; Female; HIV Infections; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Tablets; Viral Load; Zidovudine

2018
Effects of Highly Active Antiretroviral Therapy on Albuminuria in HIVinfected Persons.
    Infectious disorders drug targets, 2020, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Age Factors; Albuminuria; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Combinations; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Prospective Studies; Sex Factors; Tenofovir; Young Adult; Zidovudine

2020
Trend of HIV transmitted drug resistance before and after implementation of HAART regimen restriction in the treatment of HIV-1 infected patients in southern Taiwan.
    BMC infectious diseases, 2019, Aug-23, Volume: 19, Issue:1

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Mutation; Nevirapine; Prevalence; Reverse Transcriptase Inhibitors; Taiwan; Zidovudine

2019
Association of maternal antiretroviral use with microcephaly in children who are HIV-exposed but uninfected (SMARTT): a prospective cohort study.
    The lancet. HIV, 2020, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Child; Child, Preschool; Cyclopropanes; Drug Combinations; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Male; Microcephaly; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Puerto Rico; Tenofovir; Young Adult; Zidovudine

2020
Cryptococcal meningitis and immune reconstitution inflammatory syndrome in a pediatric patient with HIV after switching to second line antiretroviral therapy: a case report.
    BMC infectious diseases, 2020, Jan-21, Volume: 20, Issue:1

    Topics: AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Antifungal Agents; Antigens, Fungal; Benzoxazines; Child; Cryptococcus neoformans; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Female; Fluconazole; HIV; Humans; Immune Reconstitution Inflammatory Syndrome; Lamivudine; Lopinavir; Meningitis, Cryptococcal; Ritonavir; Treatment Outcome; Viral Load; Zidovudine

2020
Importance of early identification of PrEP breakthrough infections in a generalized HIV epidemic: a case report from a PrEP demonstration project in South Africa.
    BMC infectious diseases, 2020, Jul-22, Volume: 20, Issue:1

    Topics: Administration, Oral; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Combinations; Drug Resistance, Viral; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Epidemics; Female; HIV Seropositivity; HIV-1; Humans; Lamivudine; Pre-Exposure Prophylaxis; Retrospective Studies; South Africa; Treatment Outcome; Viral Load; Young Adult; Zidovudine

2020