colivelin and prolinedithiocarbamate

The inflammatory response is a critical regulator for the regeneration of axon following nervous system injury. Nuclear factor-kappa B (NF-κB) is characteristically known for its ubiquitous role in the inflammatory response. However, its functional role in adult mammalian axon growth remains elusive. Here, we found that the NF-κB signaling pathway is activated in adult sensory neurons through peripheral axotomy. Furthermore, inhibition of NF-κB in peripheral sensory neurons attenuated their axon growth in vitro and in vivo. Our results also showed that NF-κB modulated axon growth by repressing the phosphorylation of STAT3. Furthermore, activation of STAT3 significantly promoted adult optic nerve regeneration. Taken together, the findings of our study indicated that NF-κB/STAT3 cascade is a critical regulator of intrinsic axon growth capability in the adult nervous system.

Topics: Animals; Antibodies; Axons; Cells, Cultured; Female; Gene Expression Regulation; Glyceraldehyde 3-Phosphate; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; NF-kappa B; Optic Nerve; Proline; Proto-Oncogene Proteins c-myc; Regeneration; Sciatic Nerve; STAT3 Transcription Factor; Thiocarbamates