colistin has been researched along with indolicidin* in 2 studies
2 other study(ies) available for colistin and indolicidin
| Article | Year |
|---|---|
In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii.
At present, colistin is among the few antibiotics effective against Acinetobacter baumannii clinical isolates. However, in the last few years, colistin-resistant A. baumannii strains have been isolated. Therefore, antibiotics effective against these usually pan-resistant colistin-resistant A. baumannii strains are required. The main objective of this study was to analyse the activity of 15 peptides against colistin-susceptible and colistin-resistant A. baumannii. The MICs were determined by microdilution. Among these 15 antimicrobial peptides (AMPs), melittin, indolicidin and mastoparan showed good activity against both colistin-susceptible and colistin-resistant A. baumannii. Further studies of mastoparan with time-killing curves showed bactericidal activity at MIC ×8 for both colistin-susceptible and colistin-resistant A. baumannii. In conclusion, mastoparan may be a potential alternative for the treatment of colistin-resistant A. baumannii infections. Topics: Acinetobacter baumannii; Acinetobacter Infections; Amino Acid Sequence; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Colistin; Drug Resistance, Bacterial; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Melitten; Microbial Sensitivity Tests; Molecular Sequence Data; Peptides; Time Factors; Wasp Venoms | 2012 |
Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria.
The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The combination studies showed synergy between ranalexin and polymyxin E, doxycycline and clarithromycin. In addition, magainin II was shown to be synergic with betalactam antibiotics. Topics: Amino Acid Sequence; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Clarithromycin; Colistin; Doxycycline; Drug Interactions; Drug Resistance, Multiple; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Lactams; Magainins; Molecular Sequence Data; Peptides; Peptides, Cyclic; Proteins; Pseudomonas aeruginosa; Staphylococcus aureus; Xenopus Proteins | 2000 |