colibactin and aminomalonic-acid

colibactin has been researched along with aminomalonic-acid* in 1 studies

Other Studies

1 other study(ies) available for colibactin and aminomalonic-acid

Article	Year
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nature chemical biology, 2016, Volume: 12, Issue:10 Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical. Topics: Escherichia coli; Humans; Malonates; Molecular Conformation; Peptides; Polyketides	2016

Article

Year

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.

Nature chemical biology, 2016, Volume: 12, Issue:10

Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.

Topics: Escherichia coli; Humans; Malonates; Molecular Conformation; Peptides; Polyketides

2016