colforsin has been researched along with wortmannin in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (32.65) | 18.2507 |
| 2000's | 24 (48.98) | 29.6817 |
| 2010's | 9 (18.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Aoki, Y; Hirano, D; Kodama, H; Nakamura, M; Ogasawara, H; Sakanaka, C; Shimizu, T; Waga, I | 1 |
| Sharp, GW; Straub, SG | 2 |
| Cowen, DS; Manning, DR; Sowers, RS | 1 |
| al-Hafidh, J; Belham, CM; Chilvers, ER; Gould, GW; Peacock, AJ; Plevin, R; Scott, PH | 1 |
| Bahouth, SW; Fain, JN; Gokmen-Polar, Y | 1 |
| Bockaert, J; Journot, L; Villalba, M | 1 |
| Earp, HS; Graves, LM; Li, X; Yu, H | 1 |
| Ihara, Y; Ishida, H; Kagimoto, S; Kubota, A; Kuroe, A; Seino, Y; Someya, Y; Watanabe, R; Yamada, Y; Yasuda, K | 1 |
| Guo, XW; Hopfer, U; Laboisse, C; Merlin, D | 1 |
| Katsuki, H; Matsuki, N; Saito, H; Shitaka, Y | 1 |
| Hinoue, T; Kidd, M; Läuffer, JM; Modlin, IM; Schmid, SW; Tang, LH; Zhang, T | 1 |
| Filippa, N; Filloux, C; Hemmings, B; Sable, CL; Van Obberghen, E | 1 |
| Ai, W; Gong, J; Yu, L | 1 |
| Edinger, RS; Johnson, JP; Rokaw, MD | 1 |
| Adachi, T; Kagimoto, S; Kubota, A; Nunoi, K; Okamoto, Y; Seino, Y; Shihara, N; Tanaka, H; Tsuda, K; Uno, M; Xu, LM; Yamada, Y; Yasuda, K | 1 |
| Conner, TD; Dickson, JL; Ecay, TW | 2 |
| Coulonval, K; Dumont, JE; Kozma, SC; Lamy, F; Stein, RC; Vandeput, F | 1 |
| Arita, J; Kawashima, K; Yamakawa, K | 1 |
| Inanami, O; Kuwabara, M; Takahashi, K; Yoshito, A | 1 |
| Byrnes, HD; Fine, JS; Hipkin, RW; Zavodny, PJ | 1 |
| Combes, P; Crumiere, M; Dickenson, JM; Graham, S; Klotz, KN | 1 |
| Chang, WC; Gean, PW; Leu, TH; Lin, CH; Lu, KT; Yeh, SH | 1 |
| Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV | 1 |
| Greenberg, AG; Kraemer, FB; Xue, B; Zemel, MB | 1 |
| Kandolf, R; Küpper, JH; Meyer, RG; Rodemann, HP | 1 |
| Kang, SY; Kim, HM; Kim, NS; Park, SJ | 1 |
| Bengtsson, T; Evans, BA; Nevzorova, J; Summers, RJ | 1 |
| Mann, GE; Morgan, AJ; Pearson, JD; Sobrevia, L; Steinert, JR; Sugden, D; Wheeler-Jones, CP; Wyatt, AW | 1 |
| Lee, JW; Romsos, DR; Swick, AG | 1 |
| Aktories, K; Barth, H; Boutillier, S; Brock, C; Feuerstein, TJ; Leemhuis, J; Meyer, DK; Nürnberg, B | 1 |
| Slomiany, A; Slomiany, BL | 1 |
| Cline, G; Yamazaki, H; Zawalich, KC; Zawalich, WS | 1 |
| Chakir, K; Crow, MT; Jo, SH; Lakatta, EG; Leblais, V; Maltsev, V; Wang, W; Xiao, RP; Zheng, M | 1 |
| Misra, UK; Pizzo, SV | 1 |
| Blume, N; Friedrichsen, BN; Gram, VK; Lee, YC; Møldrup, A; Neubauer, N; Nielsen, JH; Petersen, JS | 1 |
| Baldwin, E; Bott, M; Fernandez-Valle, C; Iacovelli, J; Khaled, A; Lopera, J; Uddin, N | 1 |
| Caimmi, PP; Grossini, E; Mary, DA; Molinari, C; Ribichini, F; Uberti, F; Vacca, G | 1 |
| Barrett, KE; Hoda, MR; Keely, SJ; McCole, DF; Scharl, M | 1 |
| Konstantopoulos, K; Wang, P; Zhu, F | 1 |
| Hattori, Y; Oishi, H; Takano, K | 1 |
| Chetkovich, D; Golding, NL; Khurana, S; Lewis, AS; Liu, Z; Rosa, K | 1 |
| Hattori, Y; Oishi, H; Takano, K; Takebe, M; Tomita, K; Yamazaki, M; Yokoo, H | 1 |
| Abdel-Rahman, AA; Penumarti, A | 1 |
| Bayat, AA; Ghorbani, A; Jeddi-Tehrani, M; Safa, M; Saidpour, A; Zand, H | 1 |
| Aschenbach, JR; Kolisek, M; Mastrototaro, L; Sponder, G; Tietjen, U; Vormann, J | 1 |
1 review(s) available for colforsin and wortmannin
| Article | Year |
|---|---|
[Protection from pulmonary apoptosis: a new therapeutic choice for septic acute lung injury].
Topics: Androstadienes; Animals; Apoptosis; Colforsin; Drug Design; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mice; Molecular Targeted Therapy; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Alveoli; Pyridones; Quinolines; Respiratory Distress Syndrome; Sepsis; Wortmannin | 2011 |
48 other study(ies) available for colforsin and wortmannin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Arachidonic Acid; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA Primers; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Kinetics; Leukocytes; Molecular Sequence Data; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Recombinant Proteins; Signal Transduction; Thrombin; Transfection; Wortmannin | 1996 |
Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway.
Topics: Androstadienes; Animals; Calcium; Clone Cells; Colforsin; Cricetinae; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Kinetics; Signal Transduction; Time Factors; Wortmannin | 1996 |
Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Androstadienes; Animals; Bridged-Ring Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrolysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norbornanes; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiocarbamates; Thiones; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1996 |
A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; DNA; Endothelin-1; Enzyme Inhibitors; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Trachea; Wortmannin | 1996 |
Mechanisms of action of VIP and PACAP in the stimulation of insulin release.
Topics: Androstadienes; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasoactive Intestinal Peptide, Type II; Vasoactive Intestinal Peptide; Wortmannin | 1996 |
Wortmannin converts insulin but not oxytocin from an antilipolytic to a lipolytic agent in the presence of forskolin.
Topics: Adipocytes; Androstadienes; Animals; Cells, Cultured; Colforsin; Drug Interactions; Enzyme Inhibitors; Glucose; Hypoglycemic Agents; Insulin; Lipolysis; Male; Oxytocin; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Time Factors; Vanadates; Wortmannin | 1997 |
Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal.
Topics: Androstadienes; Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Colforsin; Culture Media; Culture Media, Serum-Free; DNA; DNA Fragmentation; Enzyme Inhibitors; Insulin-Like Growth Factor I; Morpholines; Necrosis; Neurons; Neuropeptides; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium; Rats; Rats, Wistar; Wortmannin | 1997 |
Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Liver; Mitogen-Activated Protein Kinases; Models, Biological; Polyenes; Protein Kinases; Rats; Recombinant Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 1997 |
Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enzyme Activation; Gastric Inhibitory Polypeptide; Humans; Receptors, Gastrointestinal Hormone; Signal Transduction; Wortmannin | 1997 |
Purinergic agonists, but not cAMP, stimulate coupled granule fusion and Cl- conductance in HT29-Cl.16E.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Androstadienes; Cell Differentiation; Cell Division; Chloride Channels; Chlorides; Clone Cells; Colforsin; Cyclic AMP; Cytoplasmic Granules; Enzyme Inhibitors; Epithelium; HT29 Cells; Humans; Intracellular Membranes; Membrane Fusion; Membrane Potentials; Patch-Clamp Techniques; Purinergic Agonists; Signal Transduction; Wortmannin | 1997 |
A potential role of Ras-mediated signal transduction for the enhancement of depolarization-induced Ca2+ responses in hippocampal neurons by basic fibroblast growth factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Antimanic Agents; Calcium; Calcium Channels; Calcium Channels, N-Type; Carcinogens; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Hippocampus; Lithium Chloride; Membrane Potentials; Naphthalenes; Neurons; Phosphodiesterase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; ras Proteins; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; DNA; Enterochromaffin Cells; Female; Flavonoids; Gastric Mucosa; Gastrins; Genistein; Humans; Neuropeptides; Neurotransmitter Agents; Octreotide; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Signal Transduction; Terfenadine; Vasoactive Intestinal Peptide; Wortmannin | 1999 |
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase.
Topics: Androstadienes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Cell Membrane; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Green Fluorescent Proteins; Humans; Insulin; Luminescent Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Serine; Wortmannin; Xenopus | 1999 |
MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Maleimides; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Thionucleotides; Transfection; Wortmannin | 1999 |
Vasopressin stimulates sodium transport in A6 cells via a phosphatidylinositide 3-kinase-dependent pathway.
Topics: Androstadienes; Biological Transport; Cell Line; Chromones; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Sodium; Vasopressins; Wortmannin | 1999 |
Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Colforsin; Cyclic AMP; Enzyme Inhibitors; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 2000 |
Inhibition of phosphatidylinositol 3-kinase does not alter forskolin-stimulated Cl(-) secretion by T84 cells.
Topics: Androstadienes; Cell Compartmentation; Cell Line; Cell Membrane; Chlorides; Chromones; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Ion Transport; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Thapsigargin; Wortmannin | 2000 |
Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hepatocyte Growth Factor; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Wortmannin | 2000 |
Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells.
Topics: Androstadienes; Animals; Apigenin; Carrier Proteins; Cell Line; Chlorides; Colforsin; Electrochemistry; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinases; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Wortmannin | 2000 |
Involvement of phosphoinositide-3-kinase and p70 S6 kinase in regulation of proliferation of rat lactotrophs in culture.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Bromocriptine; Bromodeoxyuridine; Bucladesine; Cell Division; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Estradiol; Female; Homeostasis; Insulin; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 2000 |
Hydrogen peroxide-induced activation of SAPK/JNK regulated by phosphatidylinositol 3-kinase in Chinese hamster V79 cells.
Topics: Androstadienes; Animals; Bucladesine; Calcium; Cell Line; Chelating Agents; Colforsin; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Humans; Hydrogen Peroxide; Immunoblotting; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Precipitin Tests; Wortmannin | 1999 |
Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Colforsin; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2001 |
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
Topics: Adenosine; Androstadienes; Animals; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Fusion Proteins; Wortmannin | 2001 |
A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala.
Topics: Afferent Pathways; Amygdala; Androstadienes; Animals; Chromones; Colforsin; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dimethyl Sulfoxide; Electric Stimulation; Enzyme Inhibitors; Fear; Long-Term Potentiation; Male; MAP Kinase Signaling System; Memory; Morpholines; Neuronal Plasticity; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses; Wortmannin | 2001 |
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2001 |
Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Androstadienes; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Humans; Insulin; Isoproterenol; Lipolysis; Phosphodiesterase Inhibitors; Phosphorylation; Potassium Chloride; Quinolones; Sterol Esterase; Wortmannin; Xanthines | 2001 |
Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.
Topics: Androstadienes; Anisomycin; Blotting, Western; Colforsin; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Flavonoids; Glioma; Humans; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Suramin; Transcription Factors; Wortmannin | 2002 |
Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells.
Topics: Androstadienes; Apoptosis; Bucladesine; Cell Differentiation; Cell Division; Chromones; Colforsin; Enzyme Inhibitors; HL-60 Cells; Humans; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Ribosomal Protein S6 Kinases, 70-kDa; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2002 |
Characterization of the beta-adrenoceptor subtype involved in mediation of glucose transport in L6 cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Androstadienes; Animals; Biological Transport; Bucladesine; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Glucose; Insulin; Muscle, Skeletal; Rats; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2002 |
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.
Topics: Adenosine; Androstadienes; Arginine; Biological Transport; Butadienes; Calcium; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Fetus; Flavonoids; Gene Expression; Genistein; Humans; Hydrogen-Ion Concentration; MAP Kinase Signaling System; Membrane Potentials; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitriles; Phenethylamines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Protein Isoforms; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Wortmannin | 2002 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.
Topics: Amides; Androstadienes; Animals; Brain; Colforsin; Dendrites; Enzyme Inhibitors; Genes, Reporter; Glioma; Glutathione Transferase; Humans; Kinetics; Myosin-Light-Chain Kinase; Neuroblastoma; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Recombinant Fusion Proteins; rho GTP-Binding Proteins; Rolipram; Transfection; Tumor Cells, Cultured; Wortmannin | 2004 |
Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Androstadienes; Animals; Bucladesine; Choline; Colforsin; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Isoproterenol; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Pyrimidines; Quinazolines; Rats; Receptors, Adrenergic, beta; Saliva; src-Family Kinases; Sublingual Gland; Transcriptional Activation; Wortmannin | 2004 |
Comparative effects of amino acids and glucose on insulin secretion from isolated rat or mouse islets.
Topics: Adenylyl Cyclases; Amino Acids; Androstadienes; Animals; Carbachol; Colforsin; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Mice; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Tissue Culture Techniques; Type C Phospholipases; Wortmannin | 2004 |
Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
Topics: Androstadienes; Animals; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Chromones; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Insulin-Like Growth Factor I; Ion Transport; Isoproterenol; Morpholines; Myocardial Contraction; Myocytes, Cardiac; Norepinephrine; Patch-Clamp Techniques; Peptide Fragments; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prazosin; Propanolamines; Protein Processing, Post-Translational; Rats; Receptors, Adrenergic, beta-1; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Wortmannin | 2004 |
Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
Topics: Androstadienes; Animals; bcl-Associated Death Protein; Blotting, Western; Cell Count; Cell Proliferation; Chromones; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Gene Silencing; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Immunoprecipitation; Isoquinolines; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; rap1 GTP-Binding Proteins; RNA Interference; RNA, Double-Stranded; Serine; Signal Transduction; Sulfonamides; Threonine; Thymidine; Time Factors; Up-Regulation; Wortmannin; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Animals, Newborn; Cell Line; Cell Proliferation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Enzyme Activation; Flavonoids; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Human Growth Hormone; Imidazoles; Insulin-Secreting Cells; Isoquinolines; Liraglutide; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Stimulation, Chemical; Sulfonamides; Transcription, Genetic; Transduction, Genetic; Wortmannin | 2006 |
Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27Kip expression.
Topics: Androstadienes; Animals; Blood; Cell Proliferation; Cells, Cultured; Colforsin; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Drug Synergism; Early Growth Response Protein 2; G1 Phase; Glycoproteins; Nerve Tissue Proteins; Neuregulin-1; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Schwann Cells; Signal Transduction; Wortmannin | 2007 |
Urocortin II induces nitric oxide production through cAMP and Ca2+ related pathways in endothelial cells.
Topics: Androstadienes; Animals; Aorta; Blotting, Western; Butadienes; Calcimycin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dideoxyadenosine; Endothelial Cells; Imidazoles; Ionophores; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptides, Cyclic; Pyridines; Signal Transduction; Swine; Urocortins; Wortmannin | 2009 |
Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis.
Topics: Androstadienes; Animals; Carbachol; Cell Line; Chlorides; Colforsin; Enterocolitis; Epithelial Cells; Flavonoids; Humans; Leptin; Male; MAP Kinase Signaling System; Methotrexate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Wortmannin | 2010 |
Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation.
Topics: Adenylyl Cyclases; Androstadienes; Binding Sites; Cells, Cultured; Chondrocytes; Chromones; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Enzyme Activators; Humans; Interleukin-6; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Kinase Inhibitors; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factor RelA; Transcriptional Activation; Up-Regulation; Wortmannin | 2010 |
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Topics: Age Factors; Analysis of Variance; Androstadienes; Animals; Biophysical Phenomena; Bucladesine; Colforsin; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Gerbillinae; Imidazoles; In Vitro Techniques; Ion Channel Gating; Male; Neurons; Olivary Nucleus; Patch-Clamp Techniques; Pyridines; Pyrimidines; Wortmannin | 2012 |
Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.
Topics: Acute Lung Injury; Androstadienes; Animals; Apoptosis; Cecum; Colforsin; Cyclic AMP Response Element-Binding Protein; Cytokines; Enzyme Activation; Enzyme Activators; Hypotension; Imidazoles; Ligation; Lung; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Pneumonia; Proto-Oncogene Proteins c-akt; Pyridones; Shock, Septic; Signal Transduction; Wortmannin | 2012 |
Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Topics: Adenylyl Cyclases; Adiponectin; Androstadienes; Animals; Anisoles; Arginine; Colforsin; Consciousness; Cyclic AMP; Cyclohexanes; Flavonoids; Hypotension; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Wortmannin | 2014 |
PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells.
Topics: Androstadienes; Antibodies; Apoptosis; Arrestins; B-Lymphocytes; beta-Arrestins; Cell Differentiation; Cell Line, Tumor; Chromones; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA Damage; DNA Repair; Gene Expression Regulation, Leukemic; Humans; Isoquinolines; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Sulfonamides; Thionucleotides; Tumor Suppressor Protein p53; Wortmannin | 2015 |
Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells.
Topics: Adenylyl Cyclases; Androstadienes; Cation Transport Proteins; Colforsin; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Insulin; Magnesium; p38 Mitogen-Activated Protein Kinases; Pyridazines; Signal Transduction; Spectrometry, Fluorescence; Wortmannin | 2015 |