colforsin has been researched along with rolipram in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (8.89) | 18.7374 |
| 1990's | 60 (33.33) | 18.2507 |
| 2000's | 69 (38.33) | 29.6817 |
| 2010's | 33 (18.33) | 24.3611 |
| 2020's | 2 (1.11) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Alfonso, A; Botana, LM; Botana, MA; Cabado, AG; Louzao, MC; Vieytes, MR | 1 |
| Altiok, N; Fredholm, BB | 2 |
| Heller, PH; Levine, JD; Taiwo, YO | 1 |
| Araki, T; Kato, H; Kogure, K | 1 |
| Hassall, GA; Parrott, DP; Souness, JE | 1 |
| Araki, T; Kato, H; Kogure, K; Murase, K | 1 |
| Absood, A; Chen, D; Håkanson, R | 1 |
| Balcarek, JM; Chilton, FH; Livi, GP; Torphy, TJ; Undem, BJ; White, JR | 1 |
| Donaldson, J; Hall, IP; Hill, SJ | 2 |
| Lugnier, C; Muller, B; Stoclet, JC | 1 |
| Nicholson, D; Sawynok, J; White, TD | 1 |
| Levine, JD; Taiwo, YO | 1 |
| Bucher, B; Illes, P; Pain, L; Stoclet, JC | 1 |
| Diocee, BK; Martin, W; Moodie, SA; Souness, JE | 1 |
| Bailey, IA; Kemp, PR; Radda, GK; Seymour, AM | 1 |
| Gordeladze, JO | 1 |
| Allgaier, C; Choi, BK; Hertting, G | 1 |
| Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 2 |
| Fredholm, BB; Lerner, UH; Sahlberg, K | 1 |
| Lohse, MJ; Puurunen, J; Schwabe, U | 1 |
| Fastbom, J; Fredholm, BB; Lindgren, E | 1 |
| Gustafsson, LE; Hedqvist, P; Lundin, J; Wiklund, NP | 1 |
| Fredholm, BB; Li, YO | 1 |
| Mulder, AH; Schoffelmeer, AN; Wardeh, G | 1 |
| Astrachan, DI; Astrachan, E; Davis, M; Kehne, JH; Tallman, JF | 1 |
| Löschmann, PA; Wachtel, H | 1 |
| Löschmann, PA; Rettig, KJ; Schneider, HH; Wachtel, H | 1 |
| Fredholm, BB; Jonzon, B; Lindström, K | 1 |
| Creveling, CR; Daly, JW; Ebstein, RP; Seamon, K | 1 |
| Barnes, PJ; Giembycz, MA; Meja, K; Seldon, PM | 1 |
| Kendall, DA; Wilson, VG; Wright, IK | 1 |
| Botana, LM; MacGlashan, DW | 1 |
| Dent, G; Magnussen, H; Nakashima, M; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Amirchetty-Rao, S; Kendall, DA; Wright, IK | 1 |
| Costa, T; Levi, G; Patrizio, M | 1 |
| Johnson, GV; Litersky, JM | 1 |
| Barnette, MS; Barone, FC; Manning, CD; Price, WJ | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Challiss, RA; Morgan, AJ; Murray, KJ | 1 |
| Breton, J; Griswold, DE; Marshall, PJ; Torphy, TJ; Webb, EF; White, JR | 1 |
| Akaike, N; Kawa, K; Uneyama, H; Yamashita, Y | 1 |
| Correia-de-Sá, P; Ribeiro, JA | 1 |
| Araki, T; Kanai, Y; Kato, H; Kogure, K | 1 |
| Ellis, JL; Fernandes, LB; Undem, BJ | 1 |
| Barrett, JA; Derian, CK; Rao, PE; Santulli, RJ; Solomon, HF | 1 |
| Barnard, JW; Prasad, VR; Seibert, AF; Smart, DA; Strada, SJ; Taylor, AE; Thompson, WJ | 1 |
| Ormandy, GC | 1 |
| O'Donnell, JM | 1 |
| Dickenson, JM; Hill, SJ; White, TE | 1 |
| Koch, B; Lutz-Bucher, B | 1 |
| Fischer, W; Schudt, C; Wendel, A | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
| Boeynaems, JM; Ghanem, G; Morandini, R; Portier-Lemarié, A; Renaud, A; Robaye, B | 1 |
| Adamson, RH | 1 |
| Alves, AC; Cordeiro, RS; Cruz, HN; Diaz, BL; Lagente, V; Martins, MA; Pires, AL; Serra, MF | 1 |
| Evans, CJ; Gylys, KH; Magendzo, K; Tran, N; Zaki, P | 1 |
| Briscoe, JA; Leggett, RE; Longhurst, PA; Rosenberg, DJ | 1 |
| Cantabrana, B; Hidalgo, A; Perez-Vallina, JR; Revuelta, MP | 1 |
| Ballestas, ME; Benveniste, EN | 1 |
| Baba, J; Miyashiro, M; Sawa, A; Yamashita, N | 1 |
| Kidao, S; Merricks, EP; Pryzwansky, KB | 1 |
| Khan, M; Pahan, K; Singh, I | 1 |
| Hartigan, JA; Johnson, GV; Jope, RS; Litersky, JM; Xie, H | 1 |
| Kim, DH; Lerner, A | 1 |
| Adamson, RH; Curry, FE; Fry, GN; Liu, B; Rubin, LL | 1 |
| Adamson, RH; Curry, FE; Fu, BM | 1 |
| Mercurio, AM; O'Connor, KL; Shaw, LM | 1 |
| Aardal, S; Helle, KB; Lillestłl, IK | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Hara, S; Hisa, H; Hosono, M; Satoh, S; Suzuki-Kusaba, M; Tanahashi, M; Yokoyama, H; Yoshida, M | 1 |
| Araki, T; Itoyama, Y; Kato, H; Mizugaki, M; Tanji, H | 1 |
| Dent, G; Djukanović, R; Hidi, R; Holgate, ST; Liu, E; Schudt, C; Timmermans, S | 1 |
| Blandizzi, C; Colucci, R; Del Tacca, M; Tognetti, M | 1 |
| Bischoff, E; Jonas, U; Kühn, R; Lietz, B; Schramm, M; Stief, CG; Truss, MC; Uckert, S | 1 |
| Knox, AJ; Pang, L | 2 |
| Bodstein, M; Gaspar Elsas, MI; Joseph, D; Lintomen, L; Maximiano, ES; Vargaftig, BB; Xavier Elsas, P | 1 |
| Houslay, MD; McPhee, I; Yarwood, SJ | 1 |
| O'Donnell, JM; Zhang, HT | 1 |
| Bagorda, A; Cardone, R; Casavola, V; Debellis, L; Guerra, L; Jacobson, KA; Li, AH; Reshkin, SJ | 1 |
| Beshay, E; Croze, F; Prud'homme, GJ | 1 |
| Ezeamuzie, CI | 1 |
| Botana, LM; de la Rosa, LA; Vieytes, MR; Vilariño, N | 1 |
| Barnes, PJ; Bergmann, M; Giembycz, MA; Houslay, MD; McPhee, I; Newton, R; Staples, KJ; Tomita, K | 1 |
| Bessard, G; Bréant, D; Caron, F; Corompt, E; Devillier, P | 1 |
| Hasegawa, T; Hiramatsu, K; Ito, Y; Kitaichi, K; Kume, H; Shibata, E; Shimizu, Y; Suzuki, R; Takagi, K; Takeuchi, M; Yamaki, K; Yoshida, N | 1 |
| Dortch-Carnes, J; Potter, DE | 1 |
| Bugayenko, A; Kato, GJ; Ogawa, R; Streiff, MB | 1 |
| Ashikaga, T; Kelly, JJ; Liu, L; Strada, SJ; Thompson, WJ; Vemavarapu, L; Zhu, B | 1 |
| Domenech, C; Lluch, S; Martinez-León, JB; Medina, P; Prieto, F; Segarra, G; Vila, JM | 1 |
| Higashima, M; Koshino, Y; Ohno, K | 1 |
| Chen, J; Duman, RS; Fujioka, T; Kim, JE; Lee, R; Malberg, J; Nakagawa, S; Tsuji, S | 1 |
| Bobalova, J; Mutafova-Yambolieva, VN; Smyth, L | 1 |
| Lerner, A; Moon, EY | 1 |
| Arpin, M; Bienvenu, J; Debard, AL; Lepape, A; Maghni, K; Monneret, G; Pachot, A; Venet, F | 1 |
| Clancy, JP; Cobb, BR; Fan, L; Kovacs, TE; Sorscher, EJ | 1 |
| Fujioka, A; Inouye, ST; Masumoto, KH; Nakahama, K; Shigeyoshi, Y | 1 |
| Baillie, GS; Bolger, GB; Houslay, MD; Huston, E; MacKenzie, C; McEwan, DG; Peden, AH; Steele, MR; Wallace, DA | 1 |
| Cui, H; Green, RD | 1 |
| Anam, EM; Blázquez, MA; Cerdá-Nicolás, M; Cortijo, J; Estellés, R; Issekutz, AC; Ivorra, MD; López-Martín, J; Martínez-Losa, M; Milian, L; Morcillo, EJ; O'Connor, JE; Sanz, MJ | 1 |
| Aktories, K; Barth, H; Boutillier, S; Brock, C; Feuerstein, TJ; Leemhuis, J; Meyer, DK; Nürnberg, B | 1 |
| Felekkis, K; Flies, A; Lerner, A; Moon, EY; Sherr, DH; Tiwari, S | 1 |
| Barahona, MV; Benedito, S; García-Sacristán, A; Hernández, M; Martínez, AC; Orensanz, LM; Prieto, D; Recio, P; Rivera, L | 1 |
| Ahmed, S; Foey, AD; Ozegbe, P; Williams, RO | 1 |
| Ahmed, S; Brennan, FM; Feldmann, M; Field, S; Foey, AD; Jain, A; Williams, R | 1 |
| Asrican, B; Carpenter, S; Khibnik, L; Lisman, J; Otmakhov, N; Otmakhova, N; Riahi, S | 1 |
| Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K; Teramoto, T | 1 |
| Fleming, YM; Frame, MC; Houslay, MD | 1 |
| Chen, H; Frank, DW; King, J; Sayner, SL; Stevens, T; VandeWaa, J | 1 |
| Bhattacharjee, S; Haynes-Johnson, D; Kraft, PJ; Lundeen, SG; Qiu, Y | 1 |
| Kelly, J; Strada, SJ; Thompson, WJ; Vemavarapu, L; Zhu, B | 1 |
| Fresno, M; Iñiguez, MA; Jimenez, JL; Muñoz-Fernández, MA | 1 |
| Chang, YC; Ho, CJ; Huang, CC; Lee, HT; Wang, LY; Wang, ST | 1 |
| Asrican, B; Carpenter, S; Dosemeci, A; Lisman, J; Otmakhov, N; Reese, TS; Tao-Cheng, JH | 1 |
| Dong, H; Epstein, PM; Kim, EJ; Lerner, A; Tiwari, S; Weintraub, L | 1 |
| Chang, YC; Chen, IM; Chen, YH; Lin, CH; Lin, PJ; Lin, PL; Lu, KL; Tsai, MC | 1 |
| Derkach, VA; Guire, ES; Oh, MC; Soderling, TR | 1 |
| Bengtsson, T; Evans, BA; Nevzorova, J; Summers, RJ | 1 |
| Cheng, J; Grande, JP; Gray, CE; Thompson, MA; Walker, HJ; Warner, GM; Zhou, W | 1 |
| Bobalova, J; Mutafova-Yambolieva, VN | 1 |
| Bolton, S; Butt, AM | 1 |
| Brydon, L; Ignatius, PF; Jarzynka, MJ; Jockers, R; Melan, MA; Passey, DK; Radio, NM; Rasenick, MM; Witt-Enderby, PA | 1 |
| Pettipher, R; Wettey, FR; Xue, L | 1 |
| Janciauskiene, SM; Nita, IM; Stevens, T | 1 |
| Ananthalakshmi, KV; Kombian, SB; Matowe, WC | 1 |
| Edwards, MR; Haas, J; Johnson, M; Johnston, SL; Panettieri, RA | 1 |
| Baillie, GS; Brunton, VG; Frame, MC; Houslay, MD; Leslie, NR; McEwan, DG | 1 |
| Cornu, JN; Rouprêt, M | 1 |
| Burger, S; Drenckhahn, D; Golenhofen, N; Schlegel, N; Walter, U; Waschke, J | 1 |
| Adamson, RH; Altangerel, A; Curry, FE; Drenckhahn, D; Lenz, JF; Ly, JC; Sarai, RK | 1 |
| Alvarez, E; Cairrão, E; Morgado, M; Santos-Silva, AJ; Verde, I | 1 |
| Fatma, S; Grunstein, JS; Grunstein, MM; Hu, A; Nino, G | 1 |
| Baumer, Y; Drenckhahn, D; Waschke, J | 1 |
| Chan, EC; Macintyre, DA; Read, M; Smith, R; Tyson, EK | 1 |
| Sosroseno, W; Sugiatno, E | 1 |
| Chamoto, K; Fukuda, Y; Goto, M; Hayashi, Y; Inoue, H; Kadoshima-Yamaoka, K; Miura, K; Murafuji, H; Murakawa, M; Nagahira, K; Nakatsuka, T; Nishimura, T; Tanaka, Y | 1 |
| Böhm, M; Lenz, M; Link, A; Maack, C; Selejan, S | 1 |
| Baumer, Y; Bünemann, M; Spindler, V; Waschke, J; Werthmann, RC | 1 |
| Abel, T; Baillie, GS; Brown, KM; Chen, T; Daniels, A; Descalzi, G; Havekes, R; Houslay, MD; Huang, T; Jaganath, D; Kim, SS; Li, XY; Shang, YZ; Vecsey, CG; Wimmer, M; Zhuo, M | 1 |
| Beume, R; Hirrle, A; Marx, D; Tenor, H; Wohlsen, A | 1 |
| Castro, LR; Cavellini, L; Gervasi, N; Guiot, E; Nikolaev, VO; Paupardin-Tritsch, D; Vincent, P | 1 |
| Cancino, J; González, A; Jung, JE; Metz, C; Norambuena, A; Otero, C; Retamal, C; Silva, A; Soza, A; Valenzuela, JC | 1 |
| Shivanna, M; Srinivas, SP | 1 |
| Fisher, DE; Khaled, M; Levy, C | 1 |
| Birowo, P; Kedia, GT; Kuczyk, MA; Rahardjo, D; Sandner, P; Scheller, F; Sonnenberg, JE; Thon, WF; Uckert, S | 1 |
| Patil, RV; Ramachandran, C; Sharif, NA; Srinivas, SP | 1 |
| Adderley, SP; Bowles, EA; Ellsworth, ML; Sprague, RS; Sridharan, M; Stephenson, AH | 1 |
| Bennett, PR; Chen, L; Grammatopoulos, D; Johnson, MR; Kandola, M; Lei, K; Liang, Z; Sooranna, SR | 1 |
| Dwinell, MB; Kumar, SN; Turner, JR; Zimmerman, NP | 1 |
| Carvalho, EM; Jesus, AR; Luna, T; Muniz, AL; Nascimento, M; Porto, MA; Santos, SB | 1 |
| Fisher, MJ; Liu, S; Paganini-Hill, A; Wang, SJ; Yang, F; Yu, C | 1 |
| Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY | 1 |
| Adamson, RH; Altangerel, A; Clark, JF; Curry, FE; Sarai, RK; Thirkill, TL | 1 |
| Duarte, T; Godinho, RO; Menezes-Rodrigues, FS | 1 |
| Kedia, GT; Kuczyk, MA; Merseburger, AS; Polat, H; Ückert, S | 1 |
| Campos-Toimil, M; Cuíñas, A; Elíes, J; Orallo, F | 1 |
| Basma, H; Fahrid, M; Gunji, Y; Holz, O; Kanaji, N; Liu, X; Magnussen, H; Michalski, J; Muller, KC; Nakanishi, M; Nelson, A; Nogel, S; Rabe, KF; Rennard, SI; Sato, T; Toews, ML; Wang, X | 1 |
| Canepa, E; Domenicotti, C; Fedele, E; Marengo, B; Marinari, UM; Passalacqua, M; Pronzato, MA; Ricciarelli, R | 1 |
| Abrahamsson, PA; Persson, JL; Sandberg, S; Sarwar, M | 1 |
| Doseyici, S; Erbay, E; Mehmetoglu, I; Toker, A; Yerlikaya, FH | 1 |
| Kugelmann, D; Radeva, MY; Spindler, V; Waschke, J | 1 |
| Barr, LA; Carter, RL; Cheung, JY; Coleman, RC; Feldman, AM; Gao, E; Grisanti, LA; Houser, SR; Koch, WJ; Li, X; Makarewich, CA; Myers, VD; Song, J; Tilley, DG; Troupes, CD; Yu, D; Zhu, W | 1 |
| Cascalheira, JF; Sebastião, AM; Serpa, A | 1 |
| Butchbach, ME; Cook, DJ; Dhurjati, P; Mack, SG | 1 |
| Goldberg, AL; Kukushkin, NV; Lokireddy, S | 1 |
| Bohnsack, JP; Carlson, SL; Morrow, AL | 1 |
| Ding, HF; Dong, Z; Fang, D; Huang, S; Jing, Q; Li, Y; Su, SB; Wang, W; Zhu, JY | 1 |
| Hagiwara, M; Kurimoto, K; Miyauchi, H; Nakamura, T; Ohta, H; Okamoto, I; Okuno, Y; Saitou, M; Sasaki, H; Shirane, K; Yabuta, Y; Yamamoto, T | 1 |
| Andric, N; Kopitovic, V; Pogrmic-Majkic, K; Samardzija, D; Stojkov-Mimic, N; Trninic-Pjevic, A; Vukosavljevic, J | 1 |
| Baumer, Y; Boisvert, WA; Halbherr, P; Halbherr, S; McCurdy, S; Mehta, NN; Weatherby, TM; Yamazaki, N | 1 |
| Muñoz, MD; Solís, JM | 1 |
| Fan, BF; Ou, XL; Shi, YW; Wang, XG; Xue, L | 1 |
| Alvarez, DF; Annamdevula, N; Audia, JP; Britain, A; Dunbar, G; Hardy, KS; Housley, N; Leavesley, S; Renema, P; Rich, T; Spadafora, D | 1 |
| Ahmad, F; Jing, Y; Liu, P; Lladó, A | 1 |
2 review(s) available for colforsin and rolipram
| Article | Year |
|---|---|
Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Asthma; Colforsin; Cyclic AMP; Humans; Mast Cells; Mice; Pyrrolidinones; Rolipram | 1992 |
Protein tyrosine phosphorylation modulates microvessel permeability in frog mesentery.
Topics: Animals; Anura; Arsenicals; Capillary Permeability; Colforsin; Cyclic AMP; Dimercaprol; Endothelium, Vascular; Enzyme Inhibitors; Mesentery; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Pyrrolidinones; Rolipram; Serum Albumin, Bovine; Signal Transduction | 1996 |
178 other study(ies) available for colforsin and rolipram
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Influence of protein kinase C, cAMP and phosphatase activity on histamine release produced by compound 48/80 and sodium fluoride on rat mast cells.
Topics: Animals; Colforsin; Cyclic AMP; Enzyme Activation; Ethers, Cyclic; Histamine Release; In Vitro Techniques; Mast Cells; Okadaic Acid; p-Methoxy-N-methylphenethylamine; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinases; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Sodium Fluoride; Tetradecanoylphorbol Acetate | 1992 |
Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Bradykinin; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Hydroxylamine; Hydroxylamines; Kinetics; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1992 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
Mapping of second messenger and rolipram receptors in mammalian brain.
Topics: Animals; Autoradiography; Brain Ischemia; Brain Mapping; Colforsin; Cyclic AMP; Gerbillinae; Hippocampus; In Vitro Techniques; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Drug; Rolipram; Second Messenger Systems | 1992 |
Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aorta; Cell Division; Colforsin; Cyclic AMP; DNA Replication; Guanidines; Isoenzymes; Isoquinolines; Muscle, Smooth, Vascular; Pyridazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines; Thymidine | 1992 |
Induction of tolerance to ischemia: alterations in second-messenger systems in the gerbil hippocampus.
Topics: Animals; Autoradiography; Brain Ischemia; Colforsin; Cyclic AMP; Gerbillinae; Hippocampus; Inosine Triphosphate; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Protein Kinases; Pyrrolidinones; Rolipram; Second Messenger Systems | 1992 |
Neuropeptides of the vasoactive intestinal peptide/helodermin/pituitary adenylate cyclase activating peptide family elevate plasma cAMP in mice: comparison with a range of other regulatory peptides.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP; Drug Interactions; Glucagon; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Mice; Neuropeptides; Parathyroid Hormone; Peptides; Phosphodiesterase Inhibitors; Pyrrolidinones; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rolipram; Tail; Vasoactive Intestinal Peptide | 1992 |
Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Animals; Calcium; Carbachol; Cattle; Colforsin; Cyclic AMP; Drug Interactions; In Vitro Techniques; Inositol Phosphates; Male; Membrane Lipids; Muscle, Smooth; Phospholipids; Purinones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1990 |
Involvement of rolipram-sensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Atenolol; Calcium Chloride; Colforsin; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Reserpine; Rolipram; Stereoisomerism; Xanthines | 1990 |
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Morphine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Spinal Cord; Synaptosomes | 1991 |
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dinoprostone; Epoprostenol; Hyperalgesia; Male; Phosphorylation; Protein Kinases; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Second Messenger Systems; Sensory Thresholds; Thionucleotides | 1991 |
Role of cyclic AMP in the prejunctional alpha 2-adrenoceptor modulation of noradrenaline release from the rat tail artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arteries; Axons; Azepines; Colforsin; Cyclic AMP; Electric Stimulation; Male; Nerve Endings; Neuromuscular Junction; Norepinephrine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Rolipram; Tail; Time Factors; Tritium; Vasoconstriction; Yohimbine | 1990 |
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines | 1990 |
Evidence for the compartmentation of the enzymes of cyclic AMP metabolism.
Topics: Cell Compartmentation; Colforsin; Cyclic AMP; In Vitro Techniques; Isoproterenol; Organic Chemicals; Phosphodiesterase Inhibitors; Phosphorylase a; Phosphorylases; Pyrrolidinones; Rolipram | 1990 |
The pharmacodynamic action of the cyclic AMP phosphodiesterase inhibitor rolipram on prolactin producing rat pituitary adenoma (GH4C1) cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenoma; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Enzyme Activation; Norepinephrine; Phosphatidylinositols; Phosphodiesterase Inhibitors; Pituitary Neoplasms; Prolactin; Pyrrolidinones; Rats; Receptors, Adrenergic, beta; Rolipram; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1990 |
Forskolin modulates acetylcholine release in the hippocampus independently of adenylate cyclase activation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenylyl Cyclases; Animals; Colforsin; Electric Stimulation; Enzyme Activation; Hippocampus; In Vitro Techniques; Pyrrolidinones; Rabbits; Rolipram | 1990 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
Inhibition of histamine-stimulated inositol phospholipid hydrolysis by agents which increase cyclic AMP levels in bovine tracheal smooth muscle.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Albuterol; Animals; Bucladesine; Cattle; Colforsin; Cyclic AMP; Histamine; Histamine Antagonists; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Sugar Phosphates; Trachea; Vasoactive Intestinal Peptide | 1989 |
Characterization of adenosine receptors in bone. Studies on the effect of adenosine analogues on cyclic AMP formation and bone resorption in cultured mouse calvaria.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bone and Bones; Bone Resorption; Cells, Cultured; Colforsin; Cyclic AMP; Mice; Phenylisopropyladenosine; Pyrrolidinones; Receptors, Cyclic AMP; Rolipram; Theophylline | 1987 |
Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat.
Topics: Animals; Bucladesine; Carbachol; Cimetidine; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Enzyme Activation; Histamine; In Vitro Techniques; Inositol Phosphates; Male; Parietal Cells, Gastric; Phorbol Esters; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Sugar Phosphates | 1987 |
Effects of N-ethylmaleimide and forskolin on glutamate release from rat hippocampal slices. Evidence that prejunctional adenosine receptors are linked to N-proteins, but not to adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Colforsin; Ethylmaleimide; Glutamates; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Male; Phenylisopropyladenosine; Protein Binding; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Neurotransmitter; Receptors, Purinergic; Rolipram | 1986 |
Characterization of pre- and post-junctional adenosine receptors in guinea-pig ileum.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cholinergic Fibers; Colforsin; Cyclic AMP; Diterpenes; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Phenylisopropyladenosine; Pyrrolidinones; Receptors, Cell Surface; Receptors, Neurotransmitter; Receptors, Purinergic; Rolipram; Synaptic Transmission | 1985 |
Adenosine analogues stimulate cyclic AMP formation in rabbit cerebral microvessels via adenosine A2-receptors.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cats; Cerebral Cortex; Colforsin; Cyclic AMP; Diterpenes; Microcirculation; Phenylisopropyladenosine; Pyrrolidinones; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Rolipram | 1985 |
Cyclic AMP facilitates the electrically evoked release of radiolabelled noradrenaline, dopamine and 5-hydroxytryptamine from rat brain slices.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain; Cardiotonic Agents; Colforsin; Cyclic AMP; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Norepinephrine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Serotonin | 1985 |
The role of spinal cord cyclic AMP in the acoustic startle response in rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Colforsin; Injections, Spinal; Pyrrolidinones; Rats; Rats, Inbred Strains; Reflex, Startle; Rolipram | 1986 |
Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; alpha-Methyltyrosine; Animals; Antidepressive Agents; Body Temperature; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Fenclonine; Male; Methyltyrosines; Mice; Motor Activity; Nucleotides, Cyclic; Pyrrolidinones; Reserpine; Rolipram | 1986 |
Effects of forskolin on spontaneous behavior, rectal temperature and brain cAMP levels of rats: interaction with rolipram.
Topics: Animals; Body Temperature; Brain Chemistry; Colforsin; Cyclic AMP; Drug Synergism; Grooming; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1987 |
Adenosine receptor mediated increases and decreases in cyclic AMP in hippocampal slices treated with forskolin.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Cyclic AMP; Diterpenes; Hippocampus; Male; Phenylisopropyladenosine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Rolipram | 1983 |
Transient inhibition on calcium mobilization from cultured mouse calvarial bones by the adenylate cyclase stimulator forskolin.
Topics: Animals; Bone and Bones; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Mice; Parathyroid Hormone; Pyrrolidinones; Rolipram | 1984 |
Release of norepinephrine from brain vesicular preparations: effects of an adenylate cyclase activator, forskolin, and a phosphodiesterase inhibitor.
Topics: Adenylyl Cyclases; Animals; Calcium Chloride; Cerebral Cortex; Colforsin; Diterpenes; Guinea Pigs; Kinetics; Male; Norepinephrine; Phosphodiesterase Inhibitors; Potassium; Pyrrolidinones; Rolipram | 1982 |
Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Albuterol; Amino Acid Sequence; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Cycloheximide; Dactinomycin; Dexamethasone; Dinoprostone; Drug Interactions; Flurbiprofen; Humans; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Molecular Sequence Data; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Stimulation, Chemical; Time Factors; Tumor Necrosis Factor-alpha | 1995 |
Alpha 2-adrenoceptor mediated inhibition of forskolin-stimulated cyclic AMP accumulation in isolated porcine palmar lateral veins.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Colforsin; Cyclic AMP; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Pyrrolidinones; Receptors, Adrenergic, alpha-2; Rolipram; Swine; Veins; Yohimbine | 1995 |
Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Basophils; Calcium; Colforsin; Cyclic AMP; Cytosol; Fluorescent Dyes; Fura-2; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Kinetics; Leukotrienes; Microscopy, Fluorescence; N-Formylmethionine Leucyl-Phenylalanine; Pyrrolidinones; Rolipram; Time Factors | 1994 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Dinoprost; Dose-Response Relationship, Drug; Female; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Pyridazines; Pyrrolidinones; Rolipram | 1994 |
Potentiation by forskolin of both SNP- and ANP-stimulated cyclic GMP accumulation in porcine isolated palmar lateral vein.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Colforsin; Cyclic GMP; Drug Synergism; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Pyrrolidinones; Rolipram; Veins | 1994 |
Interferon-gamma and lipopolysaccharide reduce cAMP responses in cultured glial cells: reversal by a type IV phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Astrocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Enzyme Activation; Interferon-gamma; Isoproterenol; Lipopolysaccharides; Microglia; Neuroglia; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Time Factors | 1995 |
Phosphorylation of tau in situ: inhibition of calcium-dependent proteolysis.
Topics: Calcimycin; Calcium; Colforsin; Cyclic AMP; Humans; Neurons; Peptide Hydrolases; Phosphorylation; Protease Inhibitors; Pyrrolidinones; Rolipram; tau Proteins; Tumor Cells, Cultured | 1995 |
Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dogs; Isoenzymes; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram | 1993 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Comparison of the effect of isobutylmethylxanthine and phosphodiesterase-selective inhibitors on cAMP levels in SH-SY5Y neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenylyl Cyclase Inhibitors; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Neuroblastoma; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1993 |
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear, External; Eicosanoids; Histamine Release; Humans; Imidazoles; Inflammation; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Monocytes; Nadolol; Naproxen; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazoles; Pyrrolidinones; Receptors, Adrenergic, beta; Rolipram; SRS-A; Thiazoles | 1993 |
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Astrocytoma; Bradykinin; Brain Neoplasms; Calcimycin; Calcium; Calmodulin; Colforsin; Cyclic AMP; Dopamine; Egtazic Acid; Humans; Hydroquinones; Inositol 1,4,5-Trisphosphate; Neoplasm Proteins; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured | 1993 |
Existence of rolipram-sensitive phosphodiesterase in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Bone Marrow Cells; Calcimycin; Calcium Channels; Colforsin; Cyclic AMP; Electrophysiology; Female; In Vitro Techniques; Inosine Triphosphate; Isoquinolines; Male; Megakaryocytes; Nystatin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1993 |
Evidence that the presynaptic A2a-adenosine receptor of the rat motor nerve endings is positively coupled to adenylate cyclase.
Topics: Acetylcholine; Adenosine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Dose-Response Relationship, Drug; Electric Stimulation; Female; Imines; In Vitro Techniques; Male; Phenethylamines; Phosphodiesterase Inhibitors; Phrenic Nerve; Purinergic P1 Receptor Agonists; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Purinergic P1; Rolipram | 1994 |
Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Autoradiography; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gerbillinae; Inositol 1,4,5-Trisphosphate; Male; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Drug; Rolipram; Second Messenger Systems | 1994 |
Potentiation of nonadrenergic noncholinergic relaxation of human isolated bronchus by selective inhibitors of phosphodiesterase isozymes.
Topics: Atropine; Bronchi; Colforsin; Electric Stimulation; Histamine; Humans; In Vitro Techniques; Indomethacin; Isoenzymes; Molsidomine; Muscle Relaxation; Nitroprusside; Phosphodiesterase Inhibitors; Propranolol; Purinones; Pyrrolidinones; Rolipram | 1994 |
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Benzoxazines; CD18 Antigens; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytoplasmic Granules; Endothelium, Vascular; Humans; Infant, Newborn; Isoproterenol; Macrophage-1 Antigen; Milrinone; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridones; Pyrrolidinones; Respiratory Burst; Rolipram; Umbilical Veins | 1995 |
Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenylyl Cyclases; Animals; Capillary Permeability; Colforsin; Image Processing, Computer-Assisted; Isoproterenol; Lung; Male; Pulmonary Circulation; Pyrrolidinones; Rats; Rats, Inbred Strains; Reperfusion Injury; Rolipram | 1994 |
Increased cyclic AMP reduces 5-HT1D receptor-mediated inhibition of [3H]5-hydroxytryptamine release from guinea-pig cortical slices.
Topics: Animals; Bucladesine; Cerebral Cortex; Colforsin; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Indoles; Phosphodiesterase Inhibitors; Potassium; Pyrrolidinones; Receptors, Serotonin; Rolipram; Serotonin; Serotonin Receptor Agonists; Sulfonamides; Sumatriptan | 1993 |
Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behavior maintained by differential reinforcement of low response rate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antidepressive Agents; Cerebral Cortex; Colforsin; Conditioning, Operant; Cyclic AMP; In Vitro Techniques; Male; Oxidopamine; Pyrrolidinones; Rats; Reinforcement Schedule; Rolipram | 1993 |
The effects of elevated cyclic AMP levels on histamine-H1-receptor-stimulated inositol phospholipid hydrolysis and calcium mobilization in the smooth-muscle cell line DDT1MF-2.
Topics: Animals; Calcium; Cell Line; Colforsin; Cricetinae; Cyclic AMP; Hydrolysis; Inositol Phosphates; Isoproterenol; Male; Muscle, Smooth; Phosphatidylinositols; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Adrenergic, beta; Receptors, Histamine H1; Rolipram | 1993 |
Vasopressin, unlike phorbol ester, fails to synergistically interact with pituitary adenylate cyclase activating polypeptide (PACAP) in stimulating cyclic AMP formation and ACTH secretion in cultured anterior pituitary cells.
Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Drug Interactions; Male; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland, Anterior; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Galactosamine; Hepatitis; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Phosphodiesterase Inhibitors; Pyridazines; Pyrrolidinones; Rolipram; Shock, Septic; Tumor Necrosis Factor-alpha | 1993 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Action of cAMP on expression and release of adhesion molecules in human endothelial cells.
Topics: Animals; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Humans; Leukocytes; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Sympathomimetics; Terbutaline | 1996 |
Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro.
Topics: Adrenergic beta-Agonists; Animals; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Eosinophils; Isoenzymes; Leukotriene B4; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Aggregation; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1996 |
cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Neuroblastoma; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Opioid, delta; RNA, Messenger; Rolipram | 1997 |
The role of cyclic nucleotides in guinea-pig bladder contractility.
Topics: Animals; Carbachol; Colforsin; Cyclic AMP; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Ovalbumin; Purinones; Pyrrolidinones; Rolipram; Urinary Bladder | 1997 |
Effect of Rp diastereoisomer of adenosine 3',5' cyclic-monophosphothioate on the cAMP-dependent relaxation of smooth muscle.
Topics: Animals; Colforsin; Cyclic AMP; Drug Interactions; Enzyme Inhibitors; Female; Histamine; Muscle Relaxation; Papaverine; Phosphodiesterase Inhibitors; Potassium Chloride; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Stereoisomerism; Thionucleotides; Uterine Contraction; Uterus; Vanadates; Vinca Alkaloids | 1997 |
Elevation of cyclic AMP levels in astrocytes antagonizes cytokine-induced adhesion molecule expression.
Topics: Animals; Astrocytes; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Cytokines; Drug Stability; Drug Synergism; Humans; Interleukin-1; Pyrrolidinones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rolipram; Stimulation, Chemical; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Rolipram, a selective inhibitor of phosphodiesterase type 4, pronouncedly enhanced the forskolin-induced promotion of dopamine biosynthesis in primary cultured rat mesencephalic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dopamine; Embryo, Mammalian; Female; Mesencephalon; Neurons; Phosphodiesterase Inhibitors; Pregnancy; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Vinca Alkaloids | 1997 |
Compartmentalization of PDE-4 and cAMP-dependent protein kinase in neutrophils and macrophages during phagocytosis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Adhesion; Cell Compartmentation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytochalasin D; Humans; Isoenzymes; Macrophages; Neutrophils; Nucleic Acid Synthesis Inhibitors; Peroxidase; Phagocytosis; Phagosomes; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Signal Transduction; Zymosan | 1998 |
Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenoleukodystrophy; Animals; Astrocytes; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Enzyme Inhibitors; Fatty Acids; Genetic Linkage; Interleukin-1; Isoquinolines; Neuroglia; Oxidation-Reduction; Protein Kinase Inhibitors; Pyrrolidinones; Rats; Rolipram; Sulfonamides; Tumor Necrosis Factor-alpha; X Chromosome | 1998 |
The interrelationship between selective tau phosphorylation and microtubule association.
Topics: Amino Acid Sequence; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Humans; Lithium; Microtubules; Nocodazole; Okadaic Acid; Paclitaxel; Phosphodiesterase Inhibitors; Phosphorylation; Pyrrolidinones; Rolipram; tau Proteins; Tumor Cells, Cultured | 1998 |
Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies, Anti-Idiotypic; Antigens, CD19; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Bucladesine; Calcium; Calmodulin; Cells, Cultured; Colforsin; Cyclic AMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Interleukin-2; Isoenzymes; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Pyrrolidinones; RNA, Messenger; Rolipram; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vinca Alkaloids | 1998 |
Microvascular permeability and number of tight junctions are modulated by cAMP.
Topics: Adrenergic beta-Agonists; Animals; Capillary Permeability; Colforsin; Cyclic AMP; Hemorheology; Isoproterenol; Lymphatic System; Male; Pyrrolidinones; Rana pipiens; Rolipram; Tight Junctions | 1998 |
Test of a two-pathway model for small-solute exchange across the capillary wall.
Topics: Animals; Body Water; Capillary Permeability; Colforsin; Contrast Media; Fluorescein; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Lactalbumin; Male; Models, Cardiovascular; Pyrrolidinones; Rana pipiens; Rolipram; Tight Junctions | 1998 |
Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies; Antigens, Surface; Breast Neoplasms; Chemotaxis; Colforsin; Culture Media, Conditioned; Cyclic AMP; Female; Fibroblasts; Humans; Integrin alpha6beta4; Integrins; Kinetics; Lysophospholipids; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured | 1998 |
Relaxing effects of cyclic GMP and cyclic AMP-enhancing agents on the long-lasting contraction to endothelin-1 in the porcine coronary artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Isradipine; Milrinone; Muscle, Smooth, Vascular; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Swine; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilation; Verapamil; Vinca Alkaloids | 1998 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Effects of NKH477 on renal functions and cyclic AMP production in anesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Colforsin; Cyclic AMP; Dogs; Female; Kidney; Kidney Function Tests; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Urination | 1999 |
Alterations of second messenger systems in the rat brain after 6-hydroxydopamine lesions of the medial forebrain bundle.
Topics: Animals; Antiparkinson Agents; Binding Sites; Brain; Carcinogens; Colforsin; Corpus Striatum; Male; Medial Forebrain Bundle; Oxidopamine; Phorbol 12,13-Dibutyrate; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Second Messenger Systems; Substantia Nigra; Tritium | 1999 |
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
Topics: Albuterol; Asthma; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; Interleukin-8; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Rolipram; T-Lymphocytes; Theophylline | 2000 |
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Calcium; Colforsin; Dose-Response Relationship, Drug; Ethylmaleimide; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle, Smooth; Myenteric Plexus; Nifedipine; Norepinephrine; omega-Conotoxins; Pertussis Toxin; Phenols; Receptors, Histamine H3; Rolipram; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetrodotoxin; Virulence Factors, Bordetella; Yohimbine | 2000 |
Relaxation of human ureteral smooth muscle in vitro by modulation of cyclic nucleotide-dependent pathways.
Topics: Colforsin; Cyclic AMP; Cyclic GMP; Humans; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Platelet Aggregation Inhibitors; Potassium Chloride; Purinones; Quinazolines; Rolipram; Tetrahydroisoquinolines; Ureter; Vasodilator Agents | 2000 |
Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Androstadienes; Asthma; Cell Survival; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Drug Synergism; Fluticasone; Humans; Interleukin-8; Muscle, Smooth; Phosphodiesterase Inhibitors; Propanolamines; Receptors, Adrenergic, beta-2; Respiratory System; Rolipram; Salmeterol Xinafoate; Trachea; Tumor Necrosis Factor-alpha | 2000 |
Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin E(2).
Topics: Animals; Bone Marrow Cells; Bucladesine; Cell Differentiation; Cells, Cultured; Colforsin; Colony-Forming Units Assay; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Interleukin-5; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred Strains; Prostaglandin D2; Rolipram | 2000 |
Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Cell Line; Colforsin; DNA Primers; GTPase-Activating Proteins; rap GTP-Binding Proteins; Rats; Rolipram | 2000 |
Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Male; Maze Learning; Memory; Memory, Short-Term; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Rolipram; Scopolamine | 2000 |
Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.
Topics: Adenosine; Animals; Calcium; Calcium Signaling; Cell Line; Chlorides; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Electric Conductivity; Epithelial Cells; Kidney; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptor, Adenosine A3; Receptors, Purinergic P1; Rolipram; Signal Transduction | 2000 |
Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosteroids.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Androstadienes; Cell Survival; Chemokine CCL11; Chemokines, CC; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Cytokines; Dexamethasone; Enzyme-Linked Immunosorbent Assay; Female; Fluticasone; Humans; Male; Middle Aged; Muscle, Smooth; Propanolamines; Receptors, Adrenergic, beta-2; Respiratory System; Rolipram; Salmeterol Xinafoate; Time Factors; Trachea; Tumor Necrosis Factor-alpha | 2001 |
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoimmune Diseases; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Diabetes Mellitus, Type 1; Dibutyryl Cyclic GMP; Disease Models, Animal; Drug Evaluation, Preclinical; Enterotoxins; Enzyme Induction; Female; Interferon-gamma; Interleukin-12; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred NOD; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pentoxifylline; Phosphodiesterase Inhibitors; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Tumor Necrosis Factor-alpha | 2001 |
Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Albuterol; Benzamides; Cell Degranulation; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Eosinophil Peroxidase; Eosinophils; Histamine; Humans; Nitriles; Peroxidases; Phosphodiesterase Inhibitors; Pyridines; Rolipram; Superoxides; Theophylline | 2001 |
Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89.
Topics: Adenosine Triphosphatases; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Isoquinolines; Lymphocytes; Microscopy, Fluorescence; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Sulfonamides; Thapsigargin; Time Factors | 2001 |
Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanine Nucleotide Exchange Factors; Humans; Immunosuppressive Agents; Interleukin-5; Isoquinolines; Lymphocyte Activation; Phosphorylation; rap1 GTP-Binding Proteins; Rolipram; Sulfonamides; T-Lymphocytes | 2001 |
Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Apamin; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Natriuretic Peptide, C-Type; Nitroprusside; Oxadiazoles; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Quinoxalines; Rolipram; Trachea | 2001 |
Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells.
Topics: Adult; Asthma; Cilostazol; Colforsin; Cyclic AMP; Dexamethasone; Humans; In Vitro Techniques; Interleukin-13; Kinetics; Leukocytes, Mononuclear; Male; Phosphodiesterase Inhibitors; Phytohemagglutinins; Rolipram; Tetrazoles; Theophylline | 2001 |
Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Benzophenanthridines; Ciliary Body; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; In Vitro Techniques; Iris; Naltrexone; Narcotic Antagonists; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Protein Kinase C; Pyrrolidines; Rabbits; Receptors, Opioid, kappa; Rolipram | 2002 |
Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Apoptosis; Cell Cycle; Cell Division; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Synergism; Enzyme Inhibitors; Glucocorticoids; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rolipram; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blotting, Western; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Isoproterenol; Lung; Phosphodiesterase Inhibitors; Rats; Rolipram; Time Factors | 2002 |
Relaxation induced by milrinone and rolipram in human penile arteries and veins.
Topics: Adult; Child; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Middle Aged; Milrinone; Muscle, Smooth, Vascular; Penis; Phosphodiesterase Inhibitors; Rolipram; Vasodilation | 2002 |
Cyclic AMP-mediated modulation of epileptiform afterdischarge generation in rat hippocampal slices.
Topics: Action Potentials; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Epilepsy; Hippocampus; Isoquinolines; Male; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Seizures; Sulfonamides; Thionucleotides | 2002 |
Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus.
Topics: Animals; Antidepressive Agents; Antigens, Differentiation; Bromodeoxyuridine; Cell Division; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Fluoxetine; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neural Cell Adhesion Molecule L1; Neurons; PC12 Cells; Phosphorylation; Rats; Rolipram; Selective Serotonin Reuptake Inhibitors; Sialic Acids; Sialyltransferases | 2002 |
Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Autonomic Nervous System; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dogs; Edetic Acid; Electric Stimulation; Isoproterenol; Mesenteric Arteries; Mesenteric Veins; Milrinone; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Rolipram; Second Messenger Systems | 2003 |
PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Fractionation; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytochrome c Group; Diploidy; Enzyme Inhibitors; Flow Cytometry; Humans; Intracellular Membranes; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Mitochondria; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rolipram; Tumor Cells, Cultured | 2003 |
Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils.
Topics: Biomarkers; Calcitonin; Calcitonin Gene-Related Peptide; CD11b Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Inflammation; Lipopolysaccharides; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Precursors; Rolipram; Sepsis; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.
Topics: Adenosine Deaminase; Anions; Cell Line; Chlorine; Cilostazol; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Epithelium; Glyburide; Humans; Hypoglycemic Agents; Milrinone; Mutation; Papaverine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Purinergic P1; Rolipram; Sildenafil Citrate; Sulfones; Tetrazoles; Time Factors | 2003 |
Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Biological Clocks; Cell Cycle Proteins; Cells, Cultured; Circadian Rhythm; Colforsin; Culture Media, Serum-Free; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Fibroblasts; Nuclear Proteins; Period Circadian Proteins; Phosphodiesterase Inhibitors; Rats; Rolipram; Transcription, Genetic | 2003 |
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alanine; Amino Acid Sequence; Animals; Cloning, Molecular; Colforsin; COS Cells; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Glutathione Transferase; Humans; Immunoblotting; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutation; Open Reading Frames; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Recombinant Fusion Proteins; Rolipram; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Time Factors; Two-Hybrid System Techniques | 2003 |
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Isoproterenol; Milrinone; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Response Elements; Rolipram | 2003 |
Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo.
Topics: Adenosine Monophosphate; Alkaloids; Animals; Calcium; Cell Communication; Cell Line; Colforsin; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Leukocyte Rolling; Leukocytes; Male; Microscopy, Video; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenanthrenes; Plant Extracts; Platelet Activating Factor; Protein Binding; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rolipram | 2003 |
Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.
Topics: Amides; Androstadienes; Animals; Brain; Colforsin; Dendrites; Enzyme Inhibitors; Genes, Reporter; Glioma; Glutathione Transferase; Humans; Kinetics; Myosin-Light-Chain Kinase; Neuroblastoma; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Recombinant Fusion Proteins; rho GTP-Binding Proteins; Rolipram; Transfection; Tumor Cells, Cultured; Wortmannin | 2004 |
Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Apoptosis; B-Lymphocytes; Benzimidazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Inhibitors; Fluorescent Dyes; Guanine Nucleotide Exchange Factors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Monocytes; rap1 GTP-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; T-Lymphocytes | 2004 |
Heterogeneity of neuronal and smooth muscle receptors involved in the VIP- and PACAP-induced relaxations of the pig intravesical ureter.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apamin; Capsaicin; Charybdotoxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Female; Guanylate Cyclase; Male; Muscle, Smooth; Neurons, Afferent; Neuropeptide Y; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-Conotoxin GVIA; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium Channels, Calcium-Activated; Quinoxalines; Receptors, Calcitonin Gene-Related Peptide; Receptors, Peptide; Receptors, Vasoactive Intestinal Peptide; Rolipram; Sensory Receptor Cells; Swine; Tetraethylammonium; Ureter; Vasoactive Intestinal Peptide | 2004 |
Impact of cAMP on the T-cell response to type II collagen.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antigen-Presenting Cells; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Cholera Toxin; Colforsin; Collagen Type II; Cyclic AMP; Dinoprostone; Enzyme Activation; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Mice; Mice, Inbred DBA; Models, Animal; Phosphodiesterase Inhibitors; Rolipram; Second Messenger Systems; T-Lymphocytes | 2004 |
Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Arthritis, Rheumatoid; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-10; Ionomycin; Lipopolysaccharides; Macrophages; Monocytes; Phosphodiesterase Inhibitors; Protein Kinase C; Rolipram; Synovial Membrane; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vasoactive Intestinal Peptide | 2003 |
Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent.
Topics: Animals; Colforsin; Cyclic AMP; Electric Stimulation; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Magnesium; Phosphodiesterase Inhibitors; Picrotoxin; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rolipram; Synapses | 2004 |
Inhibitory effects of group II mGluR-related drugs on memory performance in mice.
Topics: Amino Acids; Animals; Anticonvulsants; Avoidance Learning; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Isoquinolines; Male; Memory; Mice; Reaction Time; Receptors, Metabotropic Glutamate; Rolipram; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Xanthenes | 2004 |
PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Actins; Animals; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Line; Cell Movement; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Integrins; Intracellular Signaling Peptides and Proteins; Laminin; Myosin-Light-Chain Kinase; Neuropeptides; Protein Serine-Threonine Kinases; Pseudopodia; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Rolipram | 2004 |
Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Bacterial Proteins; Capillaries; Catalysis; Cell Compartmentation; Cell Membrane Permeability; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosol; Endothelial Cells; Endothelium, Vascular; Glucosyltransferases; Intercellular Junctions; Lung; Male; Phosphodiesterase Inhibitors; Pseudomonas aeruginosa; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Structure-Activity Relationship | 2004 |
Altered activities of cyclic nucleotide phosphodiesterases and soluble guanylyl cyclase in cultured RFL-6 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Culture Techniques; Cell Line; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression; Guanylate Cyclase; Lung; Nitric Oxide; Peptides, Cyclic; Phosphoric Diester Hydrolases; Rats; Receptors, Cell Surface; Rolipram; Solubility | 2004 |
Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bucladesine; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Endothelium, Vascular; Enzyme Activation; Immunohistochemistry; Lung; Phosphodiesterase Inhibitors; Phosphorylation; Rats; RNA, Messenger; Rolipram | 2004 |
Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Carbazoles; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclooxygenase 2; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Indoles; Isoquinolines; Jurkat Cells; Luciferases; Membrane Proteins; NFATC Transcription Factors; Nuclear Proteins; Plasmids; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrroles; RNA, Messenger; Rolipram; Sulfonamides; T-Lymphocytes; Transcription Factors; Transcriptional Activation; Transfection | 2004 |
cAMP response element-binding protein activation in ligation preconditioning in neonatal brain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Carotid Stenosis; Cerebrovascular Circulation; Colforsin; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Fetal Hypoxia; Functional Laterality; Hypoxia-Ischemia, Brain; Immunohistochemistry; Ischemic Preconditioning; Ligation; Male; Maze Learning; Oligodeoxyribonucleotides, Antisense; Organ Size; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Serine; Time Factors | 2004 |
Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation.
Topics: Adenylyl Cyclases; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Dendritic Spines; In Vitro Techniques; Long-Term Potentiation; Phosphodiesterase Inhibitors; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Rolipram | 2004 |
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Apoptosis; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Glucocorticoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Response Elements; Rolipram; Transcriptional Activation | 2005 |
Effects of rolipram on induction of action potential bursts in central snail neurons.
Topics: Action Potentials; Animals; Carbazoles; Cell Membrane; Central Nervous System; Colforsin; Cyclic AMP; Estrenes; Ganglia, Invertebrate; Indoles; Magnesium; Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phospholipases; Phosphoric Diester Hydrolases; Pyrroles; Pyrrolidinones; Rolipram; Signal Transduction; Snails; Synaptic Transmission | 2005 |
Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation.
Topics: Animals; Binding Sites; Biotinylation; Blotting, Western; Colforsin; Electrophysiology; Hippocampus; Long-Term Potentiation; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Phosphorylation; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Rolipram; Serine; Synaptic Transmission; Time Factors | 2006 |
Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Bucladesine; Cell Line; Cholera Toxin; Chromones; Colforsin; Cyclic AMP; Dideoxyadenosine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamines; Glucose; Isoproterenol; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Rats; Receptors, Adrenergic, beta-2; Rolipram; Signal Transduction | 2006 |
Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Cycle Proteins; Cell Line; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclin D; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dogs; Epithelial Cells; Gene Expression Regulation, Enzymologic; Kidney; Mitosis; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Quinazolines; Rolipram | 2006 |
Activation of the adenylyl cyclase/protein kinase A pathway facilitates neural release of beta-nicotinamide adenine dinucleotide in canine mesenteric artery.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Bucladesine; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dogs; Electric Stimulation; Enzyme Activation; Female; Imines; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Milrinone; NAD; Neural Pathways; Phosphodiesterase Inhibitors; Rolipram; Signal Transduction; Vasodilator Agents | 2006 |
Cyclic AMP-mediated regulation of the resting membrane potential in myelin-forming oligodendrocytes in the isolated intact rat optic nerve.
Topics: Age Factors; Animals; Animals, Newborn; Bucladesine; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Male; Membrane Potentials; Myelin Sheath; Oligodendroglia; Optic Nerve; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Rolipram | 2006 |
Modulation of melatonin receptors and G-protein function by microtubules.
Topics: Animals; Cell Shape; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Heterotrimeric GTP-Binding Proteins; Humans; Melatonin; Microtubules; Protein Kinase C; Receptor, Melatonin, MT1; Rolipram | 2006 |
Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.
Topics: Adenylyl Cyclases; Albuterol; Cells, Cultured; Colforsin; Cyclic AMP; Dideoxyadenosine; Humans; Interleukin-8; Keratinocytes; Rolipram; Trypsin | 2006 |
Alpha1-antitrypsin, old dog, new tricks. Alpha1-antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; alpha 1-Antitrypsin; Anti-Inflammatory Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Endotoxins; Humans; Interleukin-10; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Rolipram; Tumor Necrosis Factor-alpha | 2007 |
Role of protein kinase C in substance P-induced synaptic depression in the nucleus accumbens in vitro.
Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Male; Neural Inhibition; Neural Pathways; Nucleus Accumbens; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Substance P; Synaptic Transmission | 2007 |
Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Androstadienes; Anti-Inflammatory Agents; Asthma; Bronchi; CCAAT-Enhancer-Binding Proteins; Colforsin; Cyclic AMP; Epithelial Cells; Fluticasone; Gene Expression Regulation; HeLa Cells; Humans; Interleukin-1beta; Interleukin-6; NF-kappa B; Phosphodiesterase Inhibitors; Picornaviridae Infections; Pulmonary Disease, Chronic Obstructive; Response Elements; Rhinovirus; Rolipram; Salmeterol Xinafoate; Transcription, Genetic | 2007 |
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Colforsin; Colonic Neoplasms; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Resistance, Neoplasm; Humans; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; PTEN Phosphohydrolase; Rolipram; Signal Transduction | 2007 |
[Recent progress in basic research concerning the management of benign prostatic hyperplasia].
Topics: Colforsin; Humans; Male; Muscle Contraction; Muscle, Skeletal; Phenylephrine; Piperazines; Prostatic Hyperplasia; Purines; Rolipram; Sildenafil Citrate; Sulfones | 2007 |
The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization.
Topics: Adenylyl Cyclases; Animals; Antigens, CD; Bacterial Toxins; Cadherins; Capillary Permeability; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Colforsin; Coronary Vessels; Cortactin; Cyclic AMP; Endothelial Cells; Enzyme Activators; Escherichia coli Proteins; Intercellular Junctions; Mice; Mice, Transgenic; Microfilament Proteins; Neuropeptides; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Protein Transport; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rolipram; Signal Transduction; Transfection | 2008 |
Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery.
Topics: Adrenergic beta-Agonists; Animals; Cadherins; Capillary Permeability; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indicators and Reagents; Isoproterenol; Male; Microscopy, Confocal; Phosphodiesterase Inhibitors; Platelet Activating Factor; rap1 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Splanchnic Circulation | 2008 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Female; Guanylate Cyclase; Histamine; Humans; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthyridines; Nitroprusside; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Serotonin; Umbilical Arteries; Vasodilator Agents | 2008 |
Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Butadienes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dinoprostone; Enzyme Induction; Humans; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle Relaxation; Nitriles; Pertussis Toxin; Phosphodiesterase 4 Inhibitors; Rabbits; Receptors, G-Protein-Coupled; Rolipram; Signal Transduction; Sulfonamides; Trachea | 2008 |
cAMP induced Rac 1-mediated cytoskeletal reorganization in microvascular endothelium.
Topics: Antigens, CD; Cadherins; Cell Polarity; Cells, Cultured; Claudin-5; Colforsin; Cyclic AMP; Cytoskeleton; Endothelial Cells; Endothelium, Vascular; Humans; Membrane Proteins; Microcirculation; Protein Transport; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Rolipram; Skin; Thrombin | 2008 |
Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy.
Topics: Actins; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Female; HSP20 Heat-Shock Proteins; Humans; Immunoblotting; Immunoprecipitation; In Vitro Techniques; Microscopy, Fluorescence; Muscle Relaxation; Muscle, Smooth; Myometrium; Phosphorylation; Pregnancy; Rolipram | 2008 |
Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Arginase; Cell Communication; Cell Differentiation; Cell Line; Colforsin; Colorimetry; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dichlororibofuranosylbenzimidazole; Durapatite; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Penicillamine; Phosphodiesterase Inhibitors; Rolipram; S-Nitroso-N-Acetylpenicillamine | 2008 |
Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte.
Topics: Animals; Bucladesine; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Cell Line; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Female; Flow Cytometry; Immunosuppressive Agents; Indicators and Reagents; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Pyrazoles; Rolipram; Spleen; T-Lymphocytes, Cytotoxic; Tacrolimus; Thiophenes | 2009 |
Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock.
Topics: Adrenergic beta-2 Receptor Agonists; Case-Control Studies; Colforsin; Flow Cytometry; GTP-Binding Proteins; Humans; Isoproterenol; Leukocytes, Mononuclear; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rolipram; Shock, Septic; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown.
Topics: Aminoquinolines; Antigens, CD; Biosensing Techniques; Cadherins; Calcium; Capillary Permeability; cdc42 GTP-Binding Protein; Cells, Cultured; Colforsin; Cyclic AMP; Electric Impedance; Endothelial Cells; Enzyme Activators; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Gap Junctions; Humans; Microscopy, Fluorescence; Pyrimidines; rac1 GTP-Binding Protein; Rolipram; Signal Transduction; Thrombin; Time Factors | 2009 |
Sleep deprivation impairs cAMP signalling in the hippocampus.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Hippocampus; Long-Term Potentiation; Male; Memory; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Phosphodiesterase 4 Inhibitors; Rolipram; Second Messenger Systems; Sleep Deprivation; Time Factors | 2009 |
Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices.
Topics: Aminopyridines; Animals; Benzamides; Colforsin; Cyclic AMP; Cyclopropanes; Dissection; Enzyme Inhibitors; Female; In Vitro Techniques; Lung; Mucociliary Clearance; Phosphodiesterase 4 Inhibitors; Prostaglandins; Rats; Rats, Wistar; Rolipram; Terbutaline; Time Factors | 2010 |
Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons.
Topics: Adenylyl Cyclases; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Agonists; Animals; Cell Membrane; Central Nervous System Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dendrites; In Vitro Techniques; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Parietal Lobe; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Potassium; Pyramidal Cells; Receptors, Adrenergic, beta-1; Rolipram | 2010 |
Phosphatidic acid induces ligand-independent epidermal growth factor receptor endocytic traffic through PDE4 activation.
Topics: Adrenergic beta-Antagonists; Animals; Clathrin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Endocytosis; Endosomes; Enzyme Activation; ErbB Receptors; Flow Cytometry; HeLa Cells; Humans; Hydrolysis; Immunoblotting; Mice; NIH 3T3 Cells; Phosphatidic Acids; Phospholipase D; Propranolol; RNA Interference; Rolipram; Signal Transduction | 2010 |
Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.
Topics: Actomyosin; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood-Retinal Barrier; Cadherins; Cattle; Colforsin; Cyclic AMP; Electric Impedance; Endothelium, Corneal; Enzyme Activation; Epithelial Cells; Intercellular Junctions; Membrane Proteins; Microtubules; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphoproteins; Rolipram; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2010 |
Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Feedback, Physiological; Homeostasis; Humans; Immunoblotting; Infant, Newborn; Male; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Mice; Mice, Inbred C57BL; Microphthalmia-Associated Transcription Factor; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Protein Binding; RNA Interference; Rolipram; Signal Transduction; Skin | 2010 |
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Colforsin; Cyclic AMP; Cyclic GMP; Drug Evaluation, Preclinical; Ejaculation; Humans; In Vitro Techniques; Male; Milrinone; Muscle Relaxation; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Piperazines; Purines; Receptors, Adrenergic, alpha; Rolipram; Seminal Vesicles; Sildenafil Citrate; Sulfones | 2010 |
Effect of elevated intracellular cAMP levels on actomyosin contraction in bovine trabecular meshwork cells.
Topics: Actin Depolymerizing Factors; Actomyosin; Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Shape; Cells, Cultured; Colforsin; Cyclic AMP; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique, Indirect; Focal Adhesions; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Rolipram; Serine; Trabecular Meshwork | 2011 |
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
Topics: Adenine; Adenosine Triphosphate; Cilostazol; Colforsin; Cyclic AMP; Enzyme Activation; Erythrocytes; Guanine Nucleotide Exchange Factors; Humans; Iloprost; In Vitro Techniques; Isoproterenol; Models, Biological; Naphthalenes; Phosphodiesterase Inhibitors; Protein Kinase C; Rolipram; Signal Transduction; Tetradecanoylphorbol Acetate; Tetrazoles; Thionucleotides | 2011 |
Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Female; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinases; Myometrium; Phosphorylation; RNA, Small Interfering; Rolipram; Sequence Analysis, DNA | 2012 |
Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA.
Topics: Animals; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Intestinal Mucosa; Lasers; Mice; Phosphodiesterase 4 Inhibitors; Phosphorylation; Rats; rhoA GTP-Binding Protein; Rolipram; Signal Transduction; Wound Healing | 2012 |
Effect of TNF-α production inhibitors on the production of pro-inflammatory cytokines by peripheral blood mononuclear cells from HTLV-1-infected individuals.
Topics: Anti-Inflammatory Agents; Case-Control Studies; Colforsin; Female; HTLV-I Infections; Humans; Immunosuppressive Agents; Interferon-gamma; Leukocytes, Mononuclear; Male; Middle Aged; Pentoxifylline; Rolipram; Statistics, Nonparametric; Thalidomide; Tumor Necrosis Factor-alpha | 2011 |
Tissue plasminogen activator expression and barrier properties of human brain microvascular endothelial cells.
Topics: Cell Membrane Permeability; Cells, Cultured; Claudin-5; Claudins; Colforsin; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucose Transporter Type 1; Humans; Membrane Proteins; Occludin; RNA, Messenger; Rolipram; Tight Junctions; Tissue Plasminogen Activator | 2011 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rolipram; Shelterin Complex; Signal Transduction; Sulfonamides; Telomere-Binding Proteins; Theophylline | 2012 |
Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible.
Topics: Animals; Bradykinin; Capillary Permeability; Colforsin; Cyclic AMP; Lysophospholipids; Male; Microvessels; Models, Animal; rac1 GTP-Binding Protein; Rats; Rolipram; Signal Transduction; Sphingosine; Time Factors; Vasodilator Agents | 2012 |
Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle.
Topics: Adenosine; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Clenbuterol; Colforsin; Cyclic AMP; Diaphragm; Electric Stimulation; Feedback, Physiological; Fenoterol; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Male; Mice; Muscle Contraction; Receptors, Adrenergic, beta-2; Rolipram; Signal Transduction | 2012 |
Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Benzamides; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Papaverine; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostate; Purines; Pyridines; Rolipram; Signal Transduction; Sildenafil Citrate; Sulfones | 2012 |
Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca(2+) stores and inhibition of capacitative calcium entry.
Topics: Animals; Aorta, Thoracic; Calcium; Colforsin; Cyclic AMP; Imidazoles; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphodiesterase 4 Inhibitors; Pyridines; Rats; Rats, Inbred WKY; Rolipram; Vasodilation; Vasodilator Agents; Verapamil | 2013 |
Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Aminopyridines; Benzamides; Cells, Cultured; Chemotaxis; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dinoprostone; Fibroblasts; Fibronectins; Gene Expression; Humans; Iloprost; Isoenzymes; Lung; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Receptors, Epoprostenol; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP2 Subtype; Rolipram; Second Messenger Systems | 2012 |
Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activators; Gene Expression; Humans; Mice; Neurons; Phosphodiesterase 4 Inhibitors; Protein Processing, Post-Translational; Proteolysis; Rolipram; Second Messenger Systems | 2013 |
Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer.
Topics: Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Microscopy, Fluorescence; Neoplasm Metastasis; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Rolipram; Signal Transduction | 2014 |
The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic GMP; Diet, High-Fat; Fatty Acids, Nonesterified; Female; Lipolysis; Obesity; Random Allocation; Rats; Rats, Wistar; Rolipram; Weight Gain | 2014 |
PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.
Topics: A Kinase Anchor Proteins; Actin Cytoskeleton; Adherens Junctions; Animals; Binding Sites; Capillary Permeability; Cell Compartmentation; Cell Cycle Proteins; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dermis; Endothelial Cells; Gene Expression Regulation; Humans; Mice; Microvessels; Peptides; Protein Binding; rac1 GTP-Binding Protein; Rolipram; Signal Transduction | 2014 |
β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Calcium Signaling; Cardiomyopathy, Hypertrophic; Cats; Cell Line, Tumor; Colforsin; Cyclic AMP; G-Protein-Coupled Receptor Kinases; Genes, Reporter; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Failure; HEK293 Cells; Humans; Indoles; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Myocardial Contraction; Pyrrolidines; Receptors, Adrenergic, beta; Receptors, Vasopressin; Recombinant Fusion Proteins; Rolipram; Second Messenger Systems | 2014 |
Modulation of cGMP accumulation by adenosine A1 receptors at the hippocampus: influence of cGMP levels and gender.
Topics: Adenosine; Adenosine Deaminase; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Female; Hippocampus; Imidazoles; Male; Nitroprusside; Rats; Rats, Wistar; Receptor, Adenosine A1; Rolipram; Triazines; Xanthines | 2014 |
Systems biology investigation of cAMP modulation to increase SMN levels for the treatment of spinal muscular atrophy.
Topics: Albuterol; Bucladesine; Colforsin; Cyclic AMP; Epinephrine; Fibroblasts; Fluorescent Antibody Technique; Humans; Models, Biological; Monomeric GTP-Binding Proteins; Muscular Atrophy, Spinal; Promoter Regions, Genetic; Response Elements; Rolipram; Signal Transduction; Survival of Motor Neuron 2 Protein; Systems Biology | 2014 |
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.
Topics: Animals; Cell Line; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Humans; Immunoblotting; Mutation; Phosphodiesterase 4 Inhibitors; Phosphorylation; Proteasome Endopeptidase Complex; Protein Folding; Proteolysis; Rolipram; Serine; Vasodilator Agents | 2015 |
Ethanol Regulation of Synaptic GABAA α4 Receptors Is Prevented by Protein Kinase A Activation.
Topics: Animals; Central Nervous System Depressants; Cerebral Cortex; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Activators; Ethanol; Female; Male; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Rolipram; Synapses | 2016 |
Triple negative breast cancer development can be selectively suppressed by sustaining an elevated level of cellular cyclic AMP through simultaneously blocking its efflux and decomposition.
Topics: Animals; Cell Line, Tumor; Colforsin; Computational Biology; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Humans; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins; Probenecid; Rolipram; Triple Negative Breast Neoplasms | 2016 |
Topics: Animals; Cell Differentiation; Cell Proliferation; Colforsin; Embryonic Stem Cells; Epigenesis, Genetic; Germ Cells; Mice; Rolipram; Signal Transduction | 2017 |
Atrazine suppresses FSH-induced steroidogenesis and LH-dependent expression of ovulatory genes through PDE-cAMP signaling pathway in human cumulus granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Atrazine; Cell Survival; Colforsin; Cumulus Cells; Cyclic AMP; Estradiol; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Humans; Luteinizing Hormone; Ovulation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Progesterone; RNA, Messenger; Rolipram; Signal Transduction; Steroids | 2018 |
Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Carotid Arteries; Cells, Cultured; Cholesterol; Colforsin; Diet, High-Fat; Endothelial Cells; Endothelium, Vascular; Female; Femoral Artery; Humans; Hyperlipidemias; Lipoproteins, LDL; Liposomes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Rolipram; Sinus of Valsalva | 2017 |
Characterisation of the mechanisms underlying the special sensitivity of the CA2 hippocampal area to adenosine receptor antagonists.
Topics: Adenylyl Cyclases; Animals; CA1 Region, Hippocampal; CA2 Region, Hippocampal; Caffeine; Colforsin; Excitatory Postsynaptic Potentials; Male; Phosphodiesterase Inhibitors; Purinergic Agonists; Purinergic P1 Receptor Antagonists; Rats, Sprague-Dawley; Receptor, Adenosine A1; Rolipram; Synapses; Tissue Culture Techniques; Xanthines | 2019 |
Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus.
Topics: Animals; Colforsin; Cyclic AMP; Dentate Gyrus; Fear; Male; Memory; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction | 2019 |
cAMP signaling primes lung endothelial cells to activate caspase-1 during
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Alprostadil; Animals; Caspase 1; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Endothelial Cells; Gene Expression Regulation; Host-Pathogen Interactions; Inflammasomes; Interleukin-1beta; Lung; Primary Cell Culture; Pseudomonas aeruginosa; Rats; Rolipram; Signal Transduction; Single-Cell Analysis | 2020 |
Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration.
Topics: Actins; Aged; Alzheimer Disease; Animals; Brain; Colforsin; Female; Frontal Lobe; Humans; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Rolipram; Stimulation, Chemical; Synapses; Synaptosomes | 2021 |