colforsin has been researched along with morphine in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (16.67) | 18.7374 |
| 1990's | 37 (44.05) | 18.2507 |
| 2000's | 25 (29.76) | 29.6817 |
| 2010's | 7 (8.33) | 24.3611 |
| 2020's | 1 (1.19) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Eriksson, PS; Hansson, E; Rönnbäck, L | 3 |
| Bass, PP; Olson, KG; Pugh, G; Welch, SP | 1 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Jessop, JJ; Taplits, MS | 1 |
| De Vries, TJ; Mulder, AH; Schoffelmeer, AN; Van Vliet, BJ; Wardeh, G | 1 |
| Keen, M; Kelly, E; MacDermot, J; Nobbs, P | 1 |
| Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
| Nicholson, D; Reid, A; Sawynok, J | 1 |
| Nicholson, D; Sawynok, J; White, TD | 1 |
| Lucas, ML; McEwan, GT | 1 |
| Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
| Guitart, X; Nestler, EJ | 1 |
| Cox, BM; Puttfarcken, PS | 1 |
| Sadée, W; Yu, VC | 1 |
| Duman, RS; Nestler, EJ; Tallman, JF | 1 |
| Diener, M; Knobloch, SF; Rummel, W | 1 |
| Sakellaridis, N; Vernadakis, A | 1 |
| Christie-Pope, BC; Palmer, GC; Palmer, SJ | 1 |
| Crain, B; Crain, SM; Peterson, ER | 1 |
| Mulder, AH; Putters, J; Schoffelmeer, AN | 1 |
| Headley, PM; O'Shaughnessy, CT | 1 |
| Schwartz, JP | 1 |
| Ahlijanian, MK; Cooper, DM; Halford, MK | 1 |
| Childers, SR; Dworkin, SI; Kluttz, BW; Vrana, KE | 1 |
| Chakrabarti, S; Law, PY; Loh, HH | 1 |
| Lambert, DG | 1 |
| Ioverno, A; Lotti, G; Musso, NR; Pende, A; Vergassola, C | 1 |
| Jauzac, P; Polastron, J | 1 |
| Johnson, PS; Uhl, GR; Wang, JB; Wang, WF | 1 |
| Barg, J; Nah, SY; Saya, D; Vogel, Z | 1 |
| Aston-Jones, G; Shiekhattar, R | 1 |
| Avidor-Reiss, T; Bayewitch, M; Levy, R; Matus-Leibovitch, N; Nevo, I; Vogel, Z | 1 |
| Chung, KM; Kim, YH; Sim, YB; Song, DK; Suh, HW | 1 |
| Bonci, A; Williams, JT | 2 |
| Ienaga, Y; Kanematsu, K; Katsumata, S; Minami, M; Nakagawa, T; Satoh, M | 1 |
| Eki, T; Ganguly, PK; Ishikawa, Y; Iwase, M; Sato, N; Shannon, RP; Shen, YT; Vatner, DF; Vatner, SF | 1 |
| Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
| Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
| Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
| Kaplan, GB; Leite-Morris, KA; McClelland, EG; Sethi, RK | 1 |
| Ammer, H; Schulz, R | 1 |
| Hsu, H; Shah, S; Shen, J; Yoburn, BC | 1 |
| Gong, ZH; Liao, XP; Liu, JG; Qin, BY | 1 |
| Ai, W; Gong, J; Yu, L | 1 |
| Barron, BA; Caffrey, JL; Napier, LD; Roerig, SC; Yoshishige, DA | 1 |
| Agarwal, D; Glasel, JA | 1 |
| Aghajanian, GK; Jolas, T; Nestler, EJ | 1 |
| Sadée, W; Wang, Z | 2 |
| Herlenius, E; Lindahl, SG; Takita, K; Yamamoto, Y | 1 |
| Aghajanian, GK; Akbarian, S; Bates, B; Bothwell, M; Coppola, V; Fan, G; Jaenisch, R; Kosofsky, BE; Kucera, J; Liu, RJ; Nestler, EJ; Pejchal, T; Skirboll, SL; Sun, LD; Taylor, JR; Tessarollo, L; Wilson, MA | 1 |
| Ammer, H; Christ, TE | 1 |
| Lu, YF; Rothman, RB; Xu, H | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Blake, AD; Chang, SL; Li, WX; Mao, X; Yu, X | 1 |
| Christie, MJ; Hack, SP; Vaughan, CW | 1 |
| Brillet, K; Bucher, B; Lecat, S; Pattus, F; Perret, BG; Rabut, G; Wagner, R | 1 |
| Carlezon, WA; Chartoff, EH; Konradi, C; Papadopoulou, M | 1 |
| Rothman, RB; Wang, J; Wang, X; Xu, H | 1 |
| Avidor-Reiss, T; Butovsky, E; Lev, N; Schallmach, E; Steiner, D; Vogel, Z | 1 |
| Lim, G; Mao, J; Wang, S | 1 |
| Bie, B; Pan, ZZ; Peng, Y; Zhang, Y | 1 |
| Saya, D; Schallmach, E; Simonds, WF; Steiner, D; Vogel, Z | 1 |
| Avidor-Reiss, T; Saya, D; Schallmach, E; Steiner, D; Vogel, Z | 1 |
| Barke, RA; Charboneau, R; Loh, HH; Roy, S; Wang, J | 1 |
| Roeske, WR; Stropova, D; Vanderah, TW; Varga, EV; Yamamura, HI; Yue, X | 1 |
| Beltran, JA; Chang, SL; Peek, J | 1 |
| Cabot, PJ; Cheng, W; Monteith, GR; Peiris, M; Roberts-Thomson, SJ; Vetter, I; Wyse, BD; Zheng, J | 1 |
| Chu, J; Law, PY; Loh, HH; Qiu, Y; Zheng, H | 1 |
| Quillinan, N; Torrecilla, M; Wickman, K; Williams, JT | 1 |
| Liu-Chen, LY; Traynor, JR; Wang, Q | 1 |
| Chi, ZQ; Liu, JG; Sun, JF; Tao, YM; Wang, YH; Xu, XJ | 1 |
| Cong, B; Li, SJ; Ma, CL; Meng, YX; Ni, ZY; Wen, D; Zhang, YJ | 1 |
| Chakrabarti, J; Cuppoletti, J; Malinowska, DH; Tewari, K | 1 |
| Adan, RA; Meye, FJ; Ramakers, GM; Smidt, MP; van Zessen, R | 1 |
| Byrne, LS; Chang, SL; Peng, J; Sarkar, S | 1 |
| Traynor, JR; Wang, Q | 1 |
| Bobeck, EN; Chen, Q; Ingram, SL; Morgan, MM | 1 |
| Bergman, J; Chambers, DR; Goldberg, A; Imler, GH; Jacobson, AE; Luo, D; Nassehi, N; Paronis, CA; Prisinzano, TE; Rice, KC; Selley, DE; Shi, L; Sulima, A; Xie, B | 1 |
84 other study(ies) available for colforsin and morphine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Animals; Astrocytes; Brain Stem; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Isoproterenol; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Morphine-induced modulation of calcitonin gene-related peptide levels.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP; Drug Implants; Drug Tolerance; Enzyme Activation; In Vitro Techniques; Mice; Morphine; Naloxone; Rats; Spinal Cord; Substance Withdrawal Syndrome; Synaptosomes | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
In vitro effect of high doses of morphine on Con A induced lymphokine production.
Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer | 1991 |
mu-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposure.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Corpus Striatum; Morphine; Neurons; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, mu; Stimulation, Chemical; Substance Withdrawal Syndrome | 1991 |
NaF and guanine nucleotides modulate adenylate cyclase activity in NG108-15 cells by interacting with both Gs and Gi.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Colforsin; Enzyme Activation; Epoprostenol; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Iloprost; Mice; Morphine; Nervous System Neoplasms; Neuroblastoma; Pertussis Toxin; Sodium Fluoride; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1990 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Colforsin; Cyclic AMP; Injections, Spinal; Male; Morphine; Nociceptors; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Morphine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Spinal Cord; Synaptosomes | 1991 |
Opiate receptors in neuronal primary cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fetus; Morphine; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Delta and kappa opiate receptors in primary astroglial cultures from rat cerebral cortex.
Topics: Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Colforsin; Dynorphins; Enkephalin, Leucine-2-Alanine; Morphine; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1990 |
The effect of E. coli STa enterotoxin on the absorption of weakly dissociable drugs from rat proximal jejunum in vivo.
Topics: Amphetamine; Animals; Bacterial Toxins; Colforsin; Electrolytes; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lidocaine; Male; Morphine; Perfusion; Phenytoin; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Theophylline | 1990 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine.
Topics: Animals; Brain; Colforsin; Cyclic AMP; Locus Coeruleus; Male; Morphine; Naltrexone; Phosphoproteins; Phosphorylation; Protein Kinases; Proteins; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Morphine-induced desensitization and down-regulation at mu-receptors in 7315C pituitary tumor cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Morphine; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1989 |
Efficacy and tolerance of narcotic analgesics at the mu opioid receptor in differentiated human neuroblastoma cells.
Topics: Adenylyl Cyclases; Algorithms; Alprostadil; Analgesics; Cell Differentiation; Cell Line; Colforsin; Humans; Morphine; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tretinoin | 1988 |
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanosine Triphosphate; Locus Coeruleus; Male; Morphine; Narcotics; Neurons; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors; Virulence Factors, Bordetella | 1988 |
Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon.
Topics: Animals; Calcium; Carbachol; Colforsin; Colon; Cyclic AMP; Electric Stimulation; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Morphine; Neurons; Piperidines; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil | 1988 |
An unconventional response of adenylate cyclase to morphine and naloxone in the chicken during early development.
Topics: Adenylyl Cyclases; Age Factors; Animals; Chick Embryo; Colforsin; Enzyme Activation; Isoproterenol; Morphine; Naloxone; Neurotransmitter Agents; Norepinephrine; Sodium Fluoride | 1986 |
Effects of naloxone and morphine on cerebral ischemia in gerbils.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Brain Ischemia; Cerebrovascular Circulation; Colforsin; Female; Frontal Lobe; Gerbillinae; Guanine Nucleotides; In Vitro Techniques; Morphine; Motor Activity; Naloxone; Norepinephrine | 1986 |
Cyclic AMP or forskolin rapidly attenuates the depressant effects of opioids on sensory-evoked dorsal-horn responses in mouse spinal cord-ganglion explants.
Topics: Animals; Bucladesine; Colforsin; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ganglia, Spinal; Mice; Morphine; Organ Culture Techniques; Spinal Cord | 1986 |
Activation of presynaptic alpha 2-adrenoceptors attenuates the inhibitory effect of mu-opioid receptor agonists on noradrenaline release from brain slices.
Topics: Animals; Brain Chemistry; Cadmium; Clonidine; Colforsin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu | 1986 |
The use of cyclic AMP efflux studies in attempts to determine the effects of morphine on cyclic AMP formation in striatal slices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Benzazepines; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; In Vitro Techniques; Morphine; Naloxone; Rats | 1986 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Ca2+/calmodulin distinguishes between guanyl-5'-yl-imidodiphosphate- and opiate-mediated inhibition of rat striatal adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium; Calmodulin; Colforsin; Corpus Striatum; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Magnesium; Male; Morphine; Rats; Rats, Inbred Strains; Temperature | 1987 |
Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain.
Topics: Analgesics; Animals; Colforsin; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Male; Models, Molecular; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine.
Topics: Analgesics; Animals; Binding, Competitive; Cell Line; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mice; Models, Biological; Morphine; Neuroblastoma; Receptors, Opioid, mu; Time Factors | 1995 |
Characterisation of a new human neuroblastoma cell line, NAL-GT.
Topics: Calcium; Carbachol; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Female; Humans; Infant; Morphine; Neuroblastoma; Norepinephrine | 1995 |
Effects of opioid substances on cAMP response to the beta-adrenergic agonist isoproterenol in human mononuclear leukocytes.
Topics: Adult; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Isoproterenol; Leukocytes, Mononuclear; Morphine; Opioid Peptides | 1995 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Expressed mu opiate receptor couples to adenylate cyclase and phosphatidyl inositol turnover.
Topics: Adenylyl Cyclases; Animals; Cell Line; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; DNA, Complementary; Guanylyl Imidodiphosphate; Morphine; Naloxone; Phosphatidylinositols; Rats; Receptors, Opioid, mu; Recombinant Proteins; Second Messenger Systems | 1994 |
Opiate receptor agonists regulate phosphorylation of synapsin I in cocultures of rat spinal cord and dorsal root ganglion.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cell Communication; Cells, Cultured; Colforsin; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Ganglia, Spinal; Isoproterenol; Kinetics; Male; Morphine; Naloxone; Neurons; Phosphates; Phosphoproteins; Phosphorylation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin; Spinal Cord; Synapsins; Synaptosomes | 1993 |
Modulation of opiate responses in brain noradrenergic neurons by the cyclic AMP cascade: changes with chronic morphine.
Topics: Animals; Clonidine; Colforsin; Cyclic AMP; Drug Synergism; Endorphins; Locus Coeruleus; Morphine; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Naloxone; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1995 |
Differential effects of forskolin and phorbol-13-myristate injected intrathecally or intracerebroventricularly on antinociception induced by morphine or beta-endorphin administered intracerebroventricularly in the mouse.
Topics: Adenylyl Cyclases; Analgesia; Animals; beta-Endorphin; Colforsin; Enzyme Activation; Injections, Intraventricular; Injections, Spinal; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
A common mechanism mediates long-term changes in synaptic transmission after chronic cocaine and morphine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cocaine; Colforsin; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Membrane Potentials; Morphine; Receptors, GABA-B; Synaptic Transmission; Time Factors | 1996 |
Pharmacological characterization of KT-90 using cloned mu-, delta- and kappa-opioid receptors.
Topics: Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; DNA, Complementary; Morphine; Morphine Derivatives; Protein Binding; Rats; Receptors, Opioid; Recombinant Proteins | 1996 |
Neurally mediated cardiac effects of forskolin in conscious dogs.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Colforsin; Dogs; Female; Ganglionic Blockers; Heart; Heart Conduction System; Male; Morphine; Myocardial Contraction; Myocardium; Norepinephrine; Tissue Distribution | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Increased probability of GABA release during withdrawal from morphine.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Antagonists; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Interneurons; Morphine; Nerve Tissue Proteins; Organophosphorus Compounds; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Picrotoxin; Receptors, GABA-A; Salicylamides; Serotonin; Signal Transduction; Staurosporine; Strychnine; Substance Withdrawal Syndrome; Tegmentum Mesencephali; Thionucleotides | 1997 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Regulation of G protein-mediated adenylyl cyclase in striatum and cortex of opiate-dependent and opiate withdrawing mice.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Cerebral Cortex; Colforsin; Corpus Striatum; GTP-Binding Proteins; Logistic Models; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Substance Withdrawal Syndrome; Telencephalon | 1998 |
Adenylyl cyclase supersensitivity in opioid-withdrawn NG108-15 hybrid cells requires Gs but is not mediated by the Gsalpha subunit.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Colforsin; GTP-Binding Protein alpha Subunits, Gs; Humans; Hybrid Cells; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid, delta; Receptors, Prostaglandin; Signal Transduction; Substance Withdrawal Syndrome | 1998 |
The effects of antisense to Gialpha2 on opioid agonist potency and Gialpha2 protein and mRNA abundance in the mouse.
Topics: Analgesics, Opioid; Animals; Colforsin; Corpus Striatum; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Gene Expression; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Mice; Morphine; Nociceptors; Oligonucleotides, Antisense; Opioid Peptides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1998 |
The difference between methadone and morphine in regulation of delta-opioid receptors underlies the antagonistic effect of methadone on morphine-mediated cellular actions.
Topics: Adenylyl Cyclases; Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Colforsin; Cyclic AMP; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Hybrid Cells; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Phenanthridines; Protein Kinase C; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1999 |
MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Maleimides; Morphine; Morpholines; Naloxone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Opioid, mu; Recombinant Proteins; Thionucleotides; Transfection; Wortmannin | 1999 |
Canine cardiac muscarinic receptors, G proteins, and adenylate cyclase after long-term morphine.
Topics: Adenylyl Cyclases; Animals; Atrial Function; Carbachol; Colforsin; Dogs; Drug Interactions; Epinephrine; GTP-Binding Proteins; Heart; Heart Atria; Heart Ventricles; Isoproterenol; Morphine; Norepinephrine; Receptors, Muscarinic; Time Factors; Ventricular Function | 1999 |
Differential effects of opioid and adrenergic agonists on proliferation in a cultured cell line.
Topics: 3T3 Cells; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Analgesics, Opioid; Animals; Cell Culture Techniques; Cell Division; Cloning, Molecular; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morphine; Procaterol; Propanolamines; Radioligand Assay; Receptors, Adrenergic, beta-2; Receptors, Opioid, delta; RNA, Messenger; Second Messenger Systems; Transfection; Tritium | 1999 |
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cardiovascular Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Isoquinolines; Male; Membrane Potentials; Morphine; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Phenylephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Sulfonamides; Sympathomimetics; Tetrazoles; Tetrodotoxin; Thionucleotides | 2000 |
Tolerance to morphine at the mu-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine.
Topics: Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Humans; Morphine; Narcotics; Phosphorylation; Receptors, Opioid, mu; Tumor Cells, Cultured | 2000 |
Dissociation of morphine-induced cyclic AMP-upregulation and mu-opioid receptor desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics, Opioid; Cell Line; Colforsin; Cyclic AMP; Humans; Morphine; Phosphodiesterase Inhibitors; Receptors, Opioid, mu; Up-Regulation | 2000 |
Effects of neuroactive substances on the morphine-induced respiratory depression; an in vitro study.
Topics: Acetylcholine; Animals; Animals, Newborn; Colforsin; Drug Interactions; Efferent Pathways; Haloperidol; Indomethacin; Morphine; Neurons; Neurotransmitter Agents; Quinacrine; Rats; Rats, Sprague-Dawley; Respiratory Center; Respiratory Insufficiency; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 2000 |
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Topics: Aging; Animals; Avoidance Learning; Brain; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Intermediate Filament Proteins; Locus Coeruleus; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Morphine Dependence; Nerve Tissue Proteins; Nestin; Neurons; Neurotrophin 3; Signal Transduction; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2001 |
Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid-induced adenylyl cyclase supersensitivity.
Topics: Adenylyl Cyclases; Animals; Colforsin; COS Cells; Cyclic AMP; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; GTP-Binding Protein alpha Subunits; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Humans; Isoenzymes; Kidney; Morphine; Narcotics; Protein Binding; Receptors, Opioid, mu; Signal Transduction; Substance-Related Disorders; Time; Transfection | 2002 |
Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu opioid receptor.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Culture Techniques; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activators; Heterotrimeric GTP-Binding Proteins; Morphine; Narcotics; Receptors, Opioid, mu; Sulfur Radioisotopes | 2003 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Morphine and endomorphins differentially regulate micro-opioid receptor mRNA in SHSY-5Y human neuroblastoma cells.
Topics: Analgesics, Opioid; Colforsin; Cyclic AMP; Drug Interactions; Humans; Morphine; Naloxone; Narcotic Antagonists; Neuroblastoma; Oligopeptides; Receptors, Opioid, mu; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro.
Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Colforsin; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; Enzyme Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Probenecid; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission; Thioinosine; Time Factors; Uricosuric Agents; Vasodilator Agents; Xanthines | 2003 |
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics | 2003 |
Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum.
Topics: Animals; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Enzyme Inhibitors; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome | 2003 |
Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Cloning, Molecular; Colforsin; Cyclic AMP; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Morphine; Neuroblastoma; Oligonucleotides, Antisense; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2004 |
Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation.
Topics: Adenylyl Cyclases; Alternative Splicing; Animals; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Genetic Variation; Genetic Vectors; Ionomycin; Morphine; Pertussis Toxin; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Time Factors | 2005 |
cAMP and protein kinase A contribute to the downregulation of spinal glutamate transporters after chronic morphine.
Topics: Amino Acid Transport System X-AG; Analgesics, Opioid; Analysis of Variance; Animals; Blotting, Western; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dideoxyadenosine; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Isoquinolines; Male; Morphine; Nicotinic Acids; Pain Measurement; Protein Kinase Inhibitors; Rats; Spinal Cord; Sulfonamides; Symporters; Time Factors | 2005 |
cAMP-mediated mechanisms for pain sensitization during opioid withdrawal.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Colforsin; Cyclic AMP; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Imines; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Oxidoreductases; Pain; Pain Measurement; Patch-Clamp Techniques; Pyrimidines; Raphe Nuclei; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides | 2005 |
Adenylyl cyclase type-VIII activity is regulated by G(betagamma) subunits.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Chlorocebus aethiops; Colforsin; COS Cells; Dimerization; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Ionomycin; Morphine; Pertussis Toxin; Receptors, Opioid, mu | 2006 |
Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Calcium; Chlorocebus aethiops; Colforsin; COS Cells; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Ionomycin; Ionophores; Isoenzymes; Morphine; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu | 2005 |
Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway.
Topics: Adenylyl Cyclases; Animals; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Cell Differentiation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Interleukin-4; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Morphine; Pertussis Toxin; Promoter Regions, Genetic; Th2 Cells; Wounds and Injuries | 2005 |
Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Enzyme Activation; Humans; Indoles; Morphine; Naloxone; Narcotic Antagonists; Phenols; Proto-Oncogene Proteins c-raf; Receptors, Opioid, mu; Transfection | 2006 |
Expression and regulation of the mu opioid peptide receptor in TPA-differentiated HL-60 promyelocytic leukemia cells.
Topics: Analgesics, Opioid; Colforsin; Cyclic AMP; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Morphine; Naloxone; Narcotic Antagonists; NF-kappa B; Protein Binding; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2006 |
Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activators; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Humans; Male; Models, Biological; Morphine; Protein Transport; Rats; Rats, Wistar; Receptors, Opioid, mu; TRPV Cation Channels | 2008 |
Agonist-selective signaling is determined by the receptor location within the membrane domains.
Topics: Animals; Arrestins; beta-Arrestins; beta-Cyclodextrins; Cell Line; Colforsin; Etorphine; Gene Deletion; GTP-Binding Protein alpha Subunit, Gi2; Humans; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Morphine; Mutant Proteins; Protein Binding; Protein Transport; Receptors, Opioid, mu; Signal Transduction | 2008 |
Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice.
Topics: Animals; Colforsin; Cyclic AMP; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Locus Coeruleus; Male; Membrane Potentials; Mice; Mice, Knockout; Morphine; Narcotics; Neurons; Patch-Clamp Techniques | 2008 |
Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.
Topics: Analgesics, Opioid; Animals; Benzamides; Cell Line, Tumor; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glioma; Glycosylation; Humans; Kidney; Mice; Mitogen-Activated Protein Kinases; Morphine; Neuroblastoma; Piperazines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; RGS Proteins; RNA Interference; Signal Transduction; Transfection | 2009 |
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.
Topics: Analgesics, Opioid; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Endocytosis; Etorphine; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Opioid-Related Disorders; Receptors, Opioid, mu | 2010 |
Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.
Topics: Analysis of Variance; Cell Line, Tumor; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Hormone Antagonists; Humans; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid, mu; RNA, Messenger; Sincalide; Up-Regulation | 2012 |
Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Topics: Alprostadil; Biological Transport; Cadmium Chloride; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Lubiprostone; Methadone; Morphine; Naloxone; Patch-Clamp Techniques; Recombinant Proteins; Time Factors; Transfection | 2013 |
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dopaminergic Neurons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activators; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Morphine; Pregnancy; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2012 |
Interleukin-1 beta-induced up-regulation of opioid receptors in the untreated and morphine-desensitized U87 MG human astrocytoma cells.
Topics: Analysis of Variance; Astrocytoma; Cell Line, Tumor; Colforsin; Cyclic AMP; Drug Interactions; Gene Expression Regulation, Neoplastic; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Oligopeptides; Radioimmunoassay; Receptors, Opioid; RNA, Messenger; Time Factors; Up-Regulation | 2012 |
Modulation of μ-opioid receptor signaling by RGS19 in SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Animals; Benzamides; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; HEK293 Cells; Humans; Mitogen-Activated Protein Kinases; Morphine; Nociceptin; Nociceptin Receptor; Opioid Peptides; PC12 Cells; Piperazines; Protein Kinase C; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2013 |
Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Bicuculline; Colforsin; Drug Tolerance; Enzyme Activators; Enzyme Inhibitors; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Miniature Postsynaptic Potentials; Morphine; Nociception; Presynaptic Terminals; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission | 2014 |
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Ligands; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency | 2022 |