colforsin has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 248 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (13.31) | 18.7374 |
| 1990's | 138 (55.65) | 18.2507 |
| 2000's | 68 (27.42) | 29.6817 |
| 2010's | 9 (3.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hadcock, JR; Malbon, CC; Port, JD | 1 |
| Eckstein, F; Paris, S | 1 |
| Heller, PH; Levine, JD; Taiwo, YO | 1 |
| Dolphin, AC | 2 |
| Cote, P; Diehl, AM; Wand, GS; Yang, SQ | 1 |
| Duzic, E; Lanier, SM | 1 |
| Gadsby, DC; Horie, M; Hwang, TC; Nairn, AC | 1 |
| Jakobs, KH; Ronzani, M; Wieland, T | 1 |
| Chen, CH; Sugai, M; Wu, HC | 1 |
| Mitchell, J; Northup, JK; Schimmer, BP | 1 |
| Mouzou, A; Poindessault, JP; Raymond, G | 1 |
| Alafuzoff, I; Cowburn, RF; Fowler, CJ; O'Neill, C; Ravid, R; Winblad, B | 1 |
| Chen, L; Halnon, NJ; Homcy, CJ; Ishikawa, Y; Katsushika, S; Kawabe, J | 1 |
| Imaizumi, T; Iwakura, K; Iwasaki, T; Kawamoto, H; Morita, H; Sakagoshi, N; Watanabe, Y; Yoshida, H | 1 |
| Baker, HJ; Claro, E; Fain, JN; Nair, BG; Patel, TB; Shanker, G; Wallace, MA | 1 |
| Dawson, G; McAtee, P | 1 |
| Akasu, T; Tokimasa, T | 1 |
| Deckmyn, H; Kienast, J; Van Geet, C; Vermylen, J; Wittevrongel, C | 1 |
| Müller, TH; Partridge, LD; Swandulla, D | 1 |
| Cantrell, DA; Graves, JD | 1 |
| Aunis, D; Bader, MF; Rouot, B; Sontag, JM; Thierse, D | 1 |
| Mikkelsen, RB; Read, LK | 1 |
| Gilman, AG; Krupinski, J; Tang, WJ | 1 |
| Crasnier, M; Diez, E; Heller-Harrison, RA; Johnson, GL; Malbon, CC; Weiss, ER | 1 |
| Bellorin-Font, E; Lopez, C; Milanes, CL; Paz-Martinez, V; Pernalete, N; Starosta, R; Weisinger, J | 1 |
| Berti-Mattera, L; Chang, CH; Douglas, J; Hopfer, U; Sims, C; Zhou, J | 1 |
| Behl, B; Kaever, V; Resch, K; Schwinzer, R; Sommermeyer, H | 1 |
| Paris, S; Pouysségur, J | 1 |
| Berry, RW; Redman, RS | 1 |
| DuBourdieu, DJ; Morgan, DW | 1 |
| Giles, W; Irisawa, H; Nakajima, T; Wu, S | 1 |
| Brand, JG; Kare, MR; Katz, Y; Naim, M | 1 |
| Fletcher, PW; Glennon, RA; Ismaiel, AM; Rydelek-Fitzgerald, L; Teitler, M | 1 |
| Erlichman, J; Fleischer, N; Leiser, M; Litvin, Y | 1 |
| Lewis, DL; Luini, A; Weight, FF | 1 |
| Birnbaumer, L; Brown, AM; Codina, J; Imoto, Y; Reeves, JP; Yatani, A | 1 |
| Benishin, CG; Pang, PK; Zeng, YY | 1 |
| Bushfield, M; Johnson, RA; Shoshani, I; Stübner, D; Yeung, SM | 1 |
| Boyer, JL; Downes, CP; Evans, T; Harden, TK; Northup, JK; Waldo, GL | 1 |
| Lancet, D; Mollner, S; Pfeuffer, E; Pfeuffer, T | 1 |
| Dolphin, AC; McGuirk, SM; Scott, RH | 1 |
| Barak, Y; Lancet, D; Lazard, D | 1 |
| Saad, M; Strnad, CF; Wong, K | 1 |
| Hayashi, Y; Kimura, T | 1 |
| Manning, DR; Nakada, MT; Woolkalis, MJ | 1 |
| Jakobs, KH; Watanabe, Y | 2 |
| Anand-Srivastava, MB; Cantin, M | 1 |
| Anand-Srivastava, MB; Cantin, M; Srivastava, AK | 1 |
| Katada, T; Murakami, T; Yasuda, H | 1 |
| Cooney, D; Dees, C; Hekman, M; Holzhöfer, A; Keenan, AK | 1 |
| Greiner, C; Jakobs, KH | 1 |
| Anholt, RR | 1 |
| Katada, T; Oinuma, M; Ui, M | 1 |
| Katada, T; Kusakabe, K; Oinuma, M; Ui, M | 1 |
| Estey, SJ; Mansour, TE | 1 |
| Anholt, RR; Sklar, PB; Snyder, SH | 1 |
| Gierschik, P; Spiegel, AM | 1 |
| Anand-Srivastava, MB; Cantin, M; Johnson, RA; Picard, S | 1 |
| Dudai, Y; Zvi, S | 1 |
| Dudai, Y; Segal, D; Sher, B; Yovell, Y | 1 |
| Aktories, K; Jakobs, KH; Schultz, G | 1 |
| Bokoch, GM; Gilman, AG; Katada, T; Smigel, MD; Ui, M | 1 |
| Ross, EM | 1 |
| Bokoch, GM; Gilman, AG; Katada, T; Northup, JK; Ui, M | 1 |
| Ferry, N; Hanoune, J; Insel, PA; Stengel, D | 1 |
| Koumi, S; Ten Eick, RE; Wasserstrom, JA | 1 |
| Imai, A; Nashida, T; Shimomura, H | 1 |
| Biondi, C; Buzzi, M; Cavallaro, R; Fabbri, E; Ferretti, ME; Vesce, G | 1 |
| Cox, RH; Shi, QY | 1 |
| Dufresne, C; Favreau, L; Gallant, M; Gareau, Y; Guay, D; Labelle, M; Metters, KM; O'Neill, GP; Slipetz, DM | 1 |
| Akaike, N; Uneyama, C; Uneyama, H | 1 |
| Mayer, E; Sun, XP; Supplisson, S | 1 |
| Di Marzo, V; Piomelli, D; Schwartz, JC; Sokoloff, P; Vial, D | 1 |
| Chen, W; Inui, T; Kajita, Y; Ochi, Y | 1 |
| Berridge, MJ; Petersen, CC | 1 |
| Barrack, ER; Steiner, MS; Wand, GS | 1 |
| Gilman, AG; Tang, WJ | 1 |
| Otomo, S; Tsuchida, K; Watajima, H | 1 |
| Boeynaems, JM; Braekman, JC; Dumont, JE; Jacoby, C; Panneels, V; Van den Bergen, H; Van Sande, J | 1 |
| Hall, IP; Kotlikoff, MI; Kume, H; Takagi, K; Washabau, RJ | 1 |
| Greenwood, MT; Panetta, R; Patel, YC; Srikant, CB; Warszynska, A | 1 |
| Ganten, D; Kreutz, R; Pfitzer, G; Satoh, S; Wilm, C | 1 |
| Chihara, K; Fujii, Y; Gonoi, T; Inagaki, N; Seino, S; Yamada, Y | 1 |
| Goodstadt, LJ; Kozlowski, RZ; Powell, T; Twist, VW | 1 |
| Alousi, AA; Bernstein, D; Insel, PA; Jasper, JR; Leiber, D; Martin, J | 1 |
| Cowburn, RF; Eriksson, A; Marcusson, JO; O'Neill, C; Wiehager, B | 1 |
| Chen, W; Hachiya, T; Inui, T; Kajita, Y; Nakajima, Y; Ochi, Y; Okabe, H | 1 |
| Bockaert, J; Harris, B; Jouin, P; Le Nguyen, D; McClue, S; Varrault, A | 1 |
| Caligaris, L; Haymal, B; Taleisnik, S | 1 |
| Côté, TE; Izenwasser, S; Weems, HB | 1 |
| Inoue, Y; Shimamura, K; Sperelakis, N | 1 |
| Hartzell, HC; Parsons, TD | 1 |
| Chern, Y; Fong, JC; Lai, HL; Liang, Y | 1 |
| Bourne, HR; Markby, DW; Onrust, R | 1 |
| Gilman, AG; Iñiguez-Lluhi, JA; Taussig, R | 1 |
| Kish, SJ; Li, PP; Siu, KP; Warsh, JJ; Young, LT | 1 |
| Fischmeister, R; Frace, AM; Hartzell, HC; Méry, PF | 1 |
| Cortinovis, C; Klimek, F; Nogueira, E | 1 |
| Domanska-Janik, K; Pyłowa, S; Zalewska, T | 1 |
| Hornykiewicz, O; Kamble, A; Kish, SJ; Li, PP; Siu, KP; Warsh, JJ; Young, LT | 1 |
| Bilezikian, JP; Camacho, JA; Chen, G; Glusman, J; Morris, SA; Rohde, S | 1 |
| Diehl, AM; Levine, MA; Samy, S; Wand, GS; Wolfgang, D | 1 |
| Cussac, D; Enjalbert, A; Kordon, C; Saltarelli, D | 1 |
| Bünemann, M; Jakobs, KH; Laser, KT; Meyer zu Heringdorf, M; Pott, L; van Koppen, C; Zhang, C | 1 |
| Kashiwayanagi, M; Okamoto, K; Tokumitsu, Y | 1 |
| Cipris, S; Daniel, EE; Pasyk, EA | 1 |
| Gandy, S; Greengard, P; Sweeney, D; Xu, H | 1 |
| Burford, NT; Nahorski, SR | 1 |
| Dessauer, CW; Gilman, AG | 1 |
| Ebina, T; Ishikawa, Y; Kawabe, Ji; Oka, N; Schwencke, C; Toya, Y | 1 |
| Calvo, JR; Carrero, I; Guijarro, LG; Pozo, D; Prieto, JC; Segura, JJ | 1 |
| el Hadri, K; Fève, B; Pairault, J | 1 |
| Monroe, JJ; Tashjian, AH | 1 |
| Gardner, B; Hall, DA; Strange, PG | 1 |
| Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J | 1 |
| Bonkale, WL; Cowburn, RF; Fastbom, J; Ravid, R; Wiehager, B; Winblad, B | 1 |
| Grünewald, S; Michel, H; Reiländer, H | 1 |
| Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
| Civelli, O; Hartman, DS; Lanau, F; Zenner, MT | 1 |
| Chang, C; Ichikawa, A; Negishi, M; Nishigaki, N | 1 |
| Bischoff, AM; Lalley, PM; Pierrefiche, O; Richter, DW | 1 |
| Itoh, Y; Kimura, K; Oka, M; Shimidzu, T; Ukai, Y; Yoshikuni, Y | 1 |
| Belardinelli, L; Harrison, JK; Jacobson, M; Kollias-Baker, CA; Ozeck, M; Ruble, J; Shryock, JC | 1 |
| Crompton, MR; Horton, RW; Katona, CL; Lowther, S | 1 |
| Guild, SB; McFerran, BW | 1 |
| Balsamini, C; Di Giacomo, B; Diamantini, G; Fraschini, F; Lucini, V; Mor, M; Nonno, R; Pannacci, M; Plazzi, PV; Rivara, S; Spadoni, G; Stankov, BM; Tarzia, G | 1 |
| Di Giacomo, B; Diamantini, G; Esposti, D; Fraschini, F; Lucini, V; Nonno, R; Pannacci, M; Spadoni, G; Stankov, BM; Tarzia, G | 1 |
| Huang, ZH; Hurley, JH; Rao, VD; Tang, WJ; Yan, SZ | 1 |
| Olianas, MC; Onali, P | 1 |
| Cheng, ZJ; Ling, K; Ma, L; Pei, G; Pu, L; Wu, YL; Zhao, J | 1 |
| Dessauer, CW; Gilman, AG; Kleuss, C; Sunahara, RK; Whisnant, RE | 1 |
| Hammond, HK; Insel, PA; Ping, P | 1 |
| Maullu, C; Olianas, MC; Onali, P | 1 |
| Cahill, PA; McKillop, IH; Schmidt, CM; Sitzmann, JV | 1 |
| Chen, P; Halpern, M; Li, CS; Liu, W; Wang, D | 1 |
| Froehlich, JC; Wand, GS | 1 |
| Gilman, AG; Sprang, SR; Sunahara, RK; Tesmer, JJ | 1 |
| Barritt, GJ; Fernando, KC; Gregory, RB | 1 |
| Adam, G; Cartmell, J; Chaboz, S; Henningsen, R; Kemp, JA; Klingelschmidt, A; Metzler, V; Monsma, F; Mutel, V; Schaffhauser, H; Wichmann, J | 1 |
| Alberi, S; Dreifuss, JJ; Raggenbass, M | 1 |
| Ito, S; Kitamura, N; Nakazato, Y; Ohta, T | 1 |
| Couet, J; Ishikawa, Y; Lisanti, MP; Schwencke, C; Toya, Y | 1 |
| Ashby, B; Liu-Chen, LY; Luo, LY; Mao, GF; Zhu, J | 1 |
| Ma, L; Pei, G; Xin, SM; Zhang, Y; Zhao, J | 1 |
| Akaike, A; Kaneko, S; Satoh, M | 1 |
| Berrendero, F; Cebeira, M; de Miguel, R; Fernández-Ruiz, JJ; García-Gil, L; Hernández, ML; Ramos, JA; Romero, J | 1 |
| Ge, A; Ghosh, K; Hsiao, CL; Kowal, D; Tasse, R; Wardwell-Swanson, J | 1 |
| Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
| Erlich, R; Felstead, DM; Guild, SB; McFerran, BW | 1 |
| Anand-Srivastava, MB; de Champlain, J; Marcil, J | 1 |
| Clark, MJ; Liu, XY; Medzihradsky, F; Remmers, AE | 1 |
| Bispham, JR; Hill, SJ; Walker, EM | 1 |
| Juilfs, F; May, T; Wolffgramm, J | 1 |
| Howlett, AC; Meschler, JP | 1 |
| Burgos, LC; Cassel, JA; Daubert, JD; DeHaven, RN; DeHaven-Hudkins, DL; Mansson, E; Nagasaka, H; Yaksh, T; Yu, G | 1 |
| Brockie, HC; Makriyannis, A; Murphy, VL; Pertwee, RG; Ross, RA; Stevenson, LA; Templeton, F | 1 |
| Borea, PA; Caiazza, A; Gessi, S; Portaluppi, F; Rastelli, G; Varani, K | 1 |
| Dawson, LA; Ghosh, K; Kowal, D; Tasse, R | 1 |
| Anand-Srivastava, MB; Ge, C; Palaparti, A | 1 |
| Ingianni, A; Maullu, C; Olianas, MC; Onali, P | 1 |
| McDonald, TF; Shuba, LM | 1 |
| Assie, MB; Carilla-Durand, E; Chopin, P; Colpaert, FC; Halazy, S; John, GW; Kleven, MS; Koek, W; Le Grand, B; Marien, M; Palmier, C; Pauwels, PJ; Perez, M; Tarayre, JP; Valentin, JP; Verscheure, Y; Wurch, T | 1 |
| Cheng, ZJ; Hu, W; Ling, K; Ma, L; Pei, G; Wang, P; Wu, GX; Wu, YL; Zhao, J | 1 |
| Alberts, GL; Gill, GS; Im, WB; Pregenzer, JF; Slightom, JL; Zaworski, PG | 1 |
| Andria, ML; Hiller, JM; Onoprishvili, I; Simon, EJ; Vilim, FS | 1 |
| Hoyer, D; Siehler, S | 2 |
| Anand-Srivastava, MB; Garcia, R; Ge, C | 2 |
| Bilodeau, L; Chorvátová, A; Gallo-Payet, N; Gendron, L; Payet, MD | 1 |
| Iourgenko, V; Levin, LR | 1 |
| Lee, DH; Shank, RP; Wang, HY; Wild, KD | 1 |
| Beckmann, A; Fauteck, JD; Musshoff, U; Peschke, D; Peschke, E; Schmidt, F | 1 |
| Kumar, U; Lange, DC; Patel, RC; Patel, SC; Patel, YC; Rocheville, M | 1 |
| Hoffmann, T; Kurz, U; Linder, JU; Schultz, JE | 1 |
| Fan, X; Gonsiorek, W; Hipkin, RW; Lundell, D; Lunn, C; Narula, S | 1 |
| Boekhoff, I; Breer, H; Fleischer, J; Schreiber, S | 1 |
| Croskery, K; Feuerbach, D; Gazi, L; Hoyer, D; Nunn, C; Schoeffter, P | 1 |
| Grammatopoulos, D; Hillhouse, EW; Karteris, E; Randeva, H | 1 |
| Bilyeu, JD; Patel, TB; Scholich, K; Wittpoth, C | 1 |
| Gorenne, I; Haystead, TA; MacDonald, JA; Nakamoto, RK; Somlyo, AP; Somlyo, AV; Walker, LA | 1 |
| Burnside, JL; Rodriguez, L; Toll, L | 1 |
| Anand-Srivastava, MB; Di Fusco, F; Hashim, S | 1 |
| Clancy-Keen, J; Emala, CW; Hirshman, CA | 1 |
| Caruso-Neves, C; Coka-Guevara, S; Lopes, AG; Rangel, LB; Vieyra, A; Vives, D | 1 |
| Snead, OC | 1 |
| Blake, AD; Cascieri, MA; Daugherty, BL; DeMartino, JA; Di Salvo, J; Johnson, KE; Koch, GE; Liu, Y; Sirotina-Meisher, A; Springer, MS; Sullivan, KA | 1 |
| Capuzzo, A; Fabbri, E; Moon, TW; Selva, C | 1 |
| Cowan, A; Huang, P; Kehner, GB; Liu-Chen, LY | 1 |
| Brézillon, S; Detheux, M; Kotani, M; Le Poul, E; Mazarguil, H; Mollereau, C; Parmentier, M; Vakili, J; Vassart, G; Zajac, JM | 1 |
| Bannai, S; Nakamura, J; Okamura, N; Usuki, S | 1 |
| Audinot, V; Beauverger, P; Boutin, JA; Fauchère, JL; Galizzi, JP; Lahaye, C; Rodriguez, M; Suply, T | 1 |
| Assié, MB; Colpaert, FC; Cosi, C; Koek, W; Patoiseau, JF; Pauwels, PJ; Vacher, B | 1 |
| Ingianni, A; Olianas, MC; Onali, P | 1 |
| Adli, H; Bazin, R; Diot-Dupuy, F; Ferré, P; Mory, G; Wiel, M | 1 |
| Berul, CI; Gehrmann, J; Hammer, PE; Maguire, CT; Martins, DC; Meister, M; Mende, U; Neer, EJ | 1 |
| Capuzzo, A; Caselli, F; Fabbri, E; Piano, A; Selva, C | 1 |
| Johansson, AM; Payne, SL; Strange, PG | 1 |
| Arthur, JM; Jose, PO; Kobilka, BK; Seifert, R; Wenzel-Seifert, K | 1 |
| Hildebrandt, JD; Lanier, SM; Ribas, C; Sato, M; Takesono, A | 1 |
| Akerman, KE; Holmqvist, T; Kukkonen, JP; Näsman, J | 1 |
| Jin, XL; Li, JG; Liu-Chen, LY; Zhang, F | 1 |
| Furuichi, K; Hiyama, H; Kamohara, M; Matsumoto, S; Matsuo, A; Matsushime, H; Ohishi, T; Saito, T; Soga, T; Takasaki, J | 1 |
| Baxendale, RW; Fraser, LR | 1 |
| Brillet, K; Bucher, B; Lecat, S; Pattus, F; Perret, BG; Rabut, G; Wagner, R | 1 |
| Judd, AK; Kaushanskaya, A; Khroyan, T; Polgar, W; Sanchez, A; Toll, L; Tuttle, DJ | 1 |
| Albasanz, JL; Fernández, M; León, D; Martín, M; Ruíz, MA | 1 |
| Anand-Srivastava, MB; Di Fusco, F | 1 |
| Rothman, RB; Wang, J; Wang, X; Xu, H | 1 |
| Anand-Srivastava, MB; Hashim, S | 1 |
| Borasio, PG; Cervellati, F; Pareschi, MC; Pavan, B | 1 |
| Chen, J; Randeva, HS | 1 |
| Hussain, T; Lokhandwala, MF; Narkar, VA; Trivedi, M | 1 |
| Cristalli, G; Gorzalka, S; Müller, CE; Vittori, S; Volpini, R; von Kügelgen, I | 1 |
| Ambu, R; Garau, L; Olianas, MC; Onali, P | 1 |
| Hoyer, D; Nunn, C; Siehler, S; Zupanc, GK | 1 |
| de Ligt, RA; IJzerman, AP; Leurs, R; Lorenzen, A; Rivkees, SA | 1 |
| Dubocovich, ML; Masana, MI; Soares, JM | 1 |
| Dautzenberg, FM | 1 |
| Kiss, T | 1 |
| Pan, L; Pan, YX; Pasternak, GW; Xu, J; Xu, MM; Yu, R | 1 |
| Anand-Srivastava, MB; Hashim, S; Li, Y | 1 |
| Anand-Srivastava, MB; Daou, GB; Lappas, G | 1 |
| Baamonde, C; Cairns, N; Dierssen, M; Flórez, J; Lubec, G; Lumbreras, M; Martínez-Cué, C; Sallés, J | 1 |
| Calo, G; Camarda, V; Guerrini, R; Lambert, DG; Marzola, E; McDonald, J; Rowbotham, DJ; Song, W; Thompson, JP | 1 |
| Almoosa, KF; Liggett, SB; McGraw, DW; Mihlbachler, KA; Rahman, FF; Schwarb, MR; Small, KM | 1 |
| Feenstra, RW; Glennon, JC; Hesselink, MB; Long, SK; McCreary, AC; Reinders, JH; Ronken, E; Van Der Neut, M; Van Scharrenburg, G | 1 |
| Bohn, LM; Partilla, JS; Prisinzano, TE; Rothman, RB; Rutherford, JM; Tidgewell, K; Wang, X; Xu, H | 1 |
| Barnes, TA; Calò, G; Carrà, G; Fantin, M; Fanton, G; Fischetti, C; Hebbes, C; Lambert, DG; McDonald, J; Morari, M; Regoli, D; Rizzi, A; Spagnolo, B; Trapella, C | 1 |
| Balasubramaniam, A; Parker, MS; Parker, SL; Sah, R; Sallee, FR | 1 |
| Kim, SH; La, HO; Lee, DK; Min, YS; Park, SY; Ryu, JS; Shin, CY; Sohn, UD; Song, HJ; Youm, JH | 1 |
| Albasanz, JL; Barrachina, M; Ferrer, I; Martín, M; Perez, S | 1 |
| Clark, MJ; Linderman, JJ; Traynor, JR | 1 |
| Benned-Jensen, T; Rosenkilde, MM | 1 |
| Geduhn, J; Gille, A; Göttle, M; Höcherl, K; König, B; Seifert, R | 1 |
| Fei, XW; He, YL; Mei, YA; Yang, G; Zhang, M | 1 |
| Alonso-Vanegas, M; Benyhe, S; Borsodi, A; Gaona, A; Orozco-Suarez, S; Páldy, E; Rocha, L; Villeda-Hernandez, J | 1 |
| Clark, MJ; Neubig, RR; Roman, DL; Roof, RA; Talbot, JN; Tesmer, JJ; Traynor, JR | 1 |
| Chi, ZQ; Liu, JG; Sun, JF; Tao, YM; Wang, YH; Xu, XJ | 1 |
| Hussain, ME; Kumar, K; Kumar, S; Kurupati, RK; Mohan, A; Pasha, S; Seth, MK | 1 |
| Anand-Srivastava, MB; Li, Y; Sandoval, YH | 1 |
| Baamonde, C; Dierssen, M; Flórez, J; Martínez-Cué, C | 1 |
| Arrang, JM; Gbahou, F; Rouleau, A | 1 |
| Abood, ME; Anavi-Goffer, S; Baillie, GL; Bolognini, D; Horswill, JG; McAllister, S; Pertwee, RG; Reggio, PH; Ross, RA; Stephens, GJ; Strange, PG | 1 |
| Arias, JM; Arias-Montaño, JA; Escamilla-Sánchez, J; Flores-Clemente, C; Leurs, R; Osorio-Espinoza, A | 1 |
| Ford, BM; Franks, LN; Prather, PL; Radominska-Pandya, A | 1 |
1 trial(s) available for colforsin and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Blood Platelets; Brimonidine Tartrate; Colforsin; Cyclic AMP; Epinephrine; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypertension; Male; Middle Aged; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Thermodynamics | 1999 |
247 other study(ies) available for colforsin and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Cross-regulation between G-protein-mediated pathways. Acute activation of the inhibitory pathway of adenylylcyclase reduces beta 2-adrenergic receptor phosphorylation and increases beta-adrenergic responsiveness.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cricetinae; Cyclic AMP; Enzyme Activation; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Phosphorylation; Protein Kinases; Radioligand Assay; Receptors, Adrenergic, beta | 1992 |
Activation of G proteins by (Rp) and (Sp) diastereomers of guanosine 5'-[beta-thio]triphosphate in hamster fibroblasts. Differential stereospecificity of Gi, Gs and Gp.
Topics: Adenylate Cyclase Toxin; Animals; Binding Sites; Cell Line; Cell Membrane Permeability; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Fibroblasts; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Pertussis Toxin; Signal Transduction; Stereoisomerism; Substrate Specificity; Virulence Factors, Bordetella | 1992 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
The effect of phosphatase inhibitors and agents increasing cyclic-AMP-dependent phosphorylation on calcium channel currents in cultured rat dorsal root ganglion neurones: interaction with the effect of G protein activation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channels; Carrier Proteins; Colforsin; Cyclic AMP; Electrophysiology; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Neurons; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase Inhibitors; Proteins; Rats | 1992 |
Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Cyclic AMP; Enzyme Activation; Ethanol; Gene Expression; Glucagon; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Liver; Liver Regeneration; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 1992 |
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner.
Topics: 3T3 Cells; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Cell Line; Colforsin; Cyclic AMP; Edetic Acid; Egtazic Acid; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Manganese; Mice; Muscle, Smooth; PC12 Cells; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, beta; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1992 |
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance.
Topics: Acetylcholine; Adenylate Cyclase Toxin; Adrenergic beta-Agonists; Animals; Carbachol; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Histamine; Ion Channels; Isoproterenol; Membrane Proteins; Myocardium; Pertussis Toxin; Phosphorylation; Propranolol; Receptors, Adrenergic, beta; Receptors, Muscarinic; Time Factors; Virulence Factors, Bordetella | 1992 |
Stimulation and inhibition of human platelet adenylylcyclase by thiophosphorylated transducin beta gamma-subunits.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Cattle; Colforsin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Kinetics; Macromolecular Substances; Thionucleotides; Transducin | 1992 |
Bacterial ADP-ribosyltransferase with a substrate specificity of the rho protein disassembles the Golgi apparatus in Vero cells and mimics the action of brefeldin A.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenosine Diphosphate Ribose; Animals; Bacterial Proteins; Biomarkers; Brefeldin A; Ceramides; Coatomer Protein; Colforsin; Cyclopentanes; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Mannosidases; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Rho Factor; Staphylococcus aureus; Substrate Specificity; Vero Cells | 1992 |
Defective guanyl nucleotide-binding protein beta gamma subunits in a forskolin-resistant mutant of the Y1 adrenocortical cell line.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adrenal Cortex Neoplasms; Animals; Brain; Cattle; Cell Membrane; Chromatography, Gel; Clone Cells; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Macromolecular Substances; Mice; Mutagenesis; Pertussis Toxin; Rats; Rod Cell Outer Segment; Transducin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Involvement of a pertussis toxin-sensitive G-protein in excitation-contraction coupling of intact and cut-end voltage-clamped skeletal muscle fibres.
Topics: Animals; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscles; Neurons; Pertussis Toxin; Rana ridibunda; Virulence Factors, Bordetella | 1992 |
Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Aging; Aluminum; Aluminum Compounds; Alzheimer Disease; Brain; Cadaver; Colforsin; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Reference Values; Time Factors | 1992 |
Isolation and characterization of a novel cardiac adenylylcyclase cDNA.
Topics: Adenosine; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Calcium; Cattle; Colforsin; DNA; Dogs; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Molecular Sequence Data; Myocardium; Open Reading Frames; Rats; Restriction Mapping; RNA, Messenger; Sodium Fluoride | 1992 |
Effects of lithium ion on the inhibitory GTP-binding protein and its coupling response.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Blood Platelets; Centrifugation, Density Gradient; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Lithium; Magnesium; Pertussis Toxin; Receptors, Adrenergic, alpha; Ribose; Virulence Factors, Bordetella | 1991 |
Ca2+ channel currents in rat sensory neurones: interaction between guanine nucleotides, cyclic AMP and Ca2+ channel ligands.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP; Drug Interactions; Gallopamil; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Neurons, Afferent; Nicotinic Acids; Oxadiazoles; Phosphorylation; Rats | 1991 |
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Topics: Adenylyl Cyclases; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Carbachol; Cat Diseases; Cats; Cell Membrane; Cerebral Cortex; Chlorides; Colforsin; G(M1) Ganglioside; Gangliosidoses; Gangliosidosis, GM1; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Reference Values; Sodium Fluoride | 1991 |
Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Brain; Cell Line; Cholera Toxin; Colforsin; Cricetinae; Embryo, Mammalian; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hybrid Cells; Inositol Phosphates; Kinetics; Molecular Weight; Neuroblastoma; Phosphorylation; Protein Kinases; Thionucleotides; Type C Phospholipases | 1990 |
Cyclic AMP regulates an inward rectifying sodium-potassium current in dissociated bull-frog sympathetic neurones.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Membrane Potentials; Neurons; Potassium; Rana catesbeiana; Sodium; Sympathetic Nervous System; Thionucleotides; Time Factors | 1990 |
Guanine nucleotide-dependent inhibition of phospholipase C in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Aluminum; Aluminum Chloride; Aluminum Compounds; Calcimycin; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Deoxycholic Acid; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Inositol Phosphates; Kinetics; Sodium Fluoride; Thionucleotides; Thrombin; Type C Phospholipases; Umbilical Veins | 1990 |
Modulation of calcium-activated non-specific cation currents by cyclic AMP-dependent phosphorylation in neurones of Helix.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Colforsin; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Helix, Snails; Ion Channels; Neurons; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Serotonin | 1990 |
An analysis of the role of guanine nucleotide binding proteins in antigen receptor/CD3 antigen coupling to phospholipase C.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bucladesine; CD3 Complex; Cell Line; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; In Vitro Techniques; Inositol Phosphates; Receptors, Antigen, T-Cell; Signal Transduction; Type C Phospholipases | 1991 |
A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers.
Topics: Adenosine Diphosphate Ribose; Adrenal Medulla; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Bacterial Toxins; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Ethylmaleimide; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hemolysin Proteins; Kinetics; Nicotine; Norepinephrine; Pertussis Toxin; Potassium; Protein Kinase C; Second Messenger Systems; Staphylococcus aureus; Streptolysins; Veratridine; Virulence Factors, Bordetella | 1991 |
Plasmodium falciparum-infected erythrocytes contain an adenylate cyclase with properties which differ from those of the host enzyme.
Topics: Adenylyl Cyclases; Animals; Chlorides; Colforsin; Erythrocyte Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Magnesium Chloride; Manganese; Manganese Compounds; Plasmodium falciparum | 1991 |
Expression and characterization of calmodulin-activated (type I) adenylylcyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Brain; Calmodulin; Cattle; Cells, Cultured; Cloning, Molecular; Colforsin; DNA; Enzyme Activation; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lepidoptera; Manganese; Molecular Sequence Data; Recombinant Proteins | 1991 |
Rhodopsin expressed in Chinese hamster ovary cells regulates adenylyl cyclase activity.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cell Line; Colforsin; Cricetinae; DNA; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Light; Ovary; Pertussis Toxin; Phosphatidylinositols; Recombinant Proteins; Retinal Pigments; Retinaldehyde; Rhodopsin; Thionucleotides; Thrombin; Transfection; Virulence Factors, Bordetella | 1990 |
Effect of acidosis on PTH-dependent renal adenylate cyclase in phosphorus deprivation: role of G proteins.
Topics: Acidosis; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Ammonium Chloride; Animals; Cholera Toxin; Colforsin; Dogs; Ethylmaleimide; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kidney; Magnesium; Manganese; Membrane Proteins; Parathyroid Hormone; Pertussis Toxin; Phosphorus; Sodium Fluoride; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Proximal tubular epithelial cells possess a novel 42-kilodalton guanine nucleotide-binding regulatory protein.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Aluminum; Aluminum Compounds; Animals; Cell Membrane; Cholera Toxin; Colforsin; Epithelium; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kidney Tubules, Proximal; Kinetics; Male; Microvilli; Molecular Weight; NAD; Parathyroid Hormone; Pertussis Toxin; Rabbits; Virulence Factors, Bordetella | 1990 |
The G protein coupling T cell antigen receptor/CD3-complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin.
Topics: Adenosine Diphosphate Ribose; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cholera Toxin; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Lymphoma, T-Cell; Receptors, Antigen, T-Cell; Tumor Cells, Cultured; Type C Phospholipases | 1990 |
Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Colforsin; Cricetinae; Cricetulus; DNA; DNA Replication; Fibroblast Growth Factors; Fibroblasts; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Inositol Phosphates; Insulin; Kinetics; Pertussis Toxin; Phosphatidylinositols; Potassium Chloride; Recombinant Proteins; Sodium Chloride; Thionucleotides; Thrombin; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Alpha-bag cell peptide inhibits bag cell adenylate cyclase via a GTP-dependent mechanism.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Aplysia; Colforsin; Diterpenes; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Invertebrate Hormones; Neurosecretory Systems; Peptide Fragments; Pertussis Toxin; Second Messenger Systems; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Multiple pathways for signal transduction in the regulation of arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cholera Toxin; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoglobulin G; Inflammation; Macrophages; Male; Peritoneal Cavity; Pertussis Toxin; Rats; Rats, Inbred Strains; Signal Transduction; Virulence Factors, Bordetella; Zymosan | 1990 |
Mechanism of acetylcholine-induced inhibition of Ca current in bullfrog atrial myocytes.
Topics: Acetylcholine; Action Potentials; Adenylyl Cyclase Inhibitors; Animals; Calcium; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart Atria; In Vitro Techniques; Isoproterenol; Myocardium; Rana catesbeiana; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1990 |
Nonreceptor-mediated responses of adenylate cyclase in membranes from liver, muscle, and white and brown adipose tissue of obese (fa/fa) and lean (Fa/) Zucker rats.
Topics: Adenylyl Cyclases; Adipose Tissue; Adipose Tissue, Brown; Animals; Body Weight; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Liver; Muscles; Norepinephrine; Obesity; Organ Size; Rats; Rats, Zucker; Receptors, Adrenergic, beta | 1990 |
NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors.
Topics: Adenylyl Cyclases; Adenylyl Imidodiphosphate; Animals; Brain; Colforsin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Male; Membranes; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists | 1990 |
Somatostatin inhibits corticotropin-releasing factor-stimulated adrenocorticotropin release, adenylate cyclase, and activation of adenosine 3',5'-monophosphate-dependent protein kinase isoenzymes in AtT20 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Cell Line; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoenzymes; Mice; Pituitary Neoplasms; Protein Kinases; Somatostatin; Thionucleotides | 1986 |
A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line.
Topics: Adenylate Cyclase Toxin; Calcium; Cell Line; Colforsin; Cyclic AMP; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ion Channels; Membrane Potentials; Nifedipine; Pertussis Toxin; Pituitary Gland; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Thionucleotides; Virulence Factors, Bordetella | 1986 |
A G protein directly regulates mammalian cardiac calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; Ion Channels; Isoproterenol; Leupeptins; Membrane Potentials; Phosphorylation; Thionucleotides; Ventricular Function | 1987 |
Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. II. Studies with guanosine 5'-(gamma)triphosphate.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Arteries; Bucladesine; Calcium; Calcium Channels; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Thionucleotides; Vasoconstriction | 1989 |
Cation and structural requirements for P site-mediated inhibition of adenylate cyclase.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Brain; Colforsin; Deoxyadenine Nucleotides; Dideoxyadenosine; Dideoxynucleosides; Egtazic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Magnesium; Manganese; Receptors, Purinergic; Structure-Activity Relationship; Thionucleotides | 1989 |
Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Aluminum; Aluminum Compounds; Animals; Brain; Cattle; Colforsin; Enzyme Activation; Erythrocyte Membrane; Female; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Macromolecular Substances; Placenta; Pregnancy; Receptors, Purinergic; Thionucleotides; Turkeys; Type C Phospholipases | 1989 |
Olfactory adenylyl cyclase. Identification and purification of a novel enzyme form.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Calcium; Calmodulin; Chromatography, Affinity; Cilia; Colforsin; Epithelium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Molecular Weight; Olfactory Mucosa; Rats; Rats, Inbred Strains; Thionucleotides | 1989 |
An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by guanine nucleotide analogues and (-)-baclofen.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Baclofen; Calcium Channels; Cells, Cultured; Cholera Toxin; Colforsin; Culture Techniques; Electrophysiology; Enzyme Activation; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Neurons, Afferent; Protein Kinase C; Rats; Thionucleotides; Type C Phospholipases | 1989 |
Bovine olfactory cilia preparation: thiol-modulated odorant-sensitive adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Cattle; Cell Membrane; Cell Separation; Cilia; Colforsin; Dithiothreitol; Enzyme Activation; Epithelium; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Odorants; Olfactory Mucosa; Rats; Second Messenger Systems; Smell; Thionucleotides; Turbinates | 1989 |
Dual regulation of neutrophil adenylate cyclase by fluoride and its relationship to cellular activation.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Colforsin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Sodium Fluoride; Superoxides; Thionucleotides; Virulence Factors, Bordetella | 1987 |
Inhibition by vanadyl of adenylate cyclase activation reactions in rat adrenal membranes.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenal Glands; Animals; Bucladesine; Cell Membrane; Colforsin; Cosyntropin; Diterpenes; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Male; Rats; Rats, Inbred Strains; Thionucleotides; Vanadates; Vanadium | 1985 |
Alterations in components of adenylate cyclase associated with transformation of chicken embryo fibroblasts by Rous sarcoma virus.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Cholera Toxin; Colforsin; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Pertussis Toxin; Thionucleotides; Virulence Factors, Bordetella | 1986 |
Inhibition of Ns-stimulated human platelet adenylate cyclase by forskolin.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Alprostadil; Blood Platelets; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Ethylmaleimide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Magnesium; Manganese; Thionucleotides | 1986 |
Atrial natriuretic factor receptors are negatively coupled to adenylate cyclase in cultured atrial and ventricular cardiocytes.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Alprostadil; Animals; Animals, Newborn; Cells, Cultured; Colforsin; Dopamine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Heart Atria; Heart Ventricles; Isoproterenol; Myocardium; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Thionucleotides | 1986 |
Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Aorta; Atrial Natriuretic Factor; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Male; Molecular Weight; NAD; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Thionucleotides; Virulence Factors, Bordetella | 1987 |
Reduction in the activity of the stimulatory guanine nucleotide-binding protein in the myocardium of spontaneously hypertensive rats.
Topics: Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hypertension; Isoproterenol; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Adrenergic, beta; Sarcolemma; Thionucleotides | 1987 |
Unimpaired coupling of phosphorylated, desensitized beta-adrenoceptor to Gs in a reconstitution system.
Topics: Adenylyl Cyclases; Animals; Colforsin; Erythrocytes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Phosphorylation; Receptors, Adrenergic, beta; Thionucleotides; Turkeys | 1987 |
Guanine nucleotide-independent inhibition of adenylate cyclase by a stimulatory hormone.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Alprostadil; Cell Membrane; Colforsin; Ethylmaleimide; Fluorides; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Thionucleotides; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Functional reconstitution of the olfactory membrane: incorporation of the olfactory adenylate cyclase in liposomes.
Topics: Adenylyl Cyclases; Animals; Cilia; Colforsin; Epithelium; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Liposomes; Olfactory Mucosa; Phosphatidylcholines; Rana catesbeiana; Thionucleotides | 1988 |
Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain Chemistry; Colforsin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Liver; Pertussis Toxin; Rabbits; Rats; Thionucleotides; Virulence Factors, Bordetella | 1986 |
A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Calmodulin; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Macromolecular Substances; Pertussis Toxin; Swine; Thionucleotides; Virulence Factors, Bordetella | 1987 |
GTP binding regulatory proteins of adenylate cyclase in Schistosoma mansoni at different stages of development.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Membranes; Pertussis Toxin; Schistosoma mansoni; Serotonin; Sodium Fluoride; Thionucleotides; Virulence Factors, Bordetella | 1988 |
The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants.
Topics: Adenylyl Cyclases; Animals; Cilia; Colforsin; Enzyme Activation; Fruit; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Magnoliopsida; Male; Odorants; Olfactory Mucosa; Plants; Rana catesbeiana; Rats; Sensory Receptor Cells; Solvents; Thionucleotides | 1986 |
Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Basophils; Cell Line; Cell Membrane; Colforsin; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Leukemia, Experimental; Magnesium; Rats; Thionucleotides | 1985 |
Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Chymotrypsin; Colforsin; Erythrocyte Membrane; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Kinetics; Thionucleotides; Turkeys | 1985 |
Ninhibin: a sperm factor attenuates the atrial natriuretic factor mediated inhibition of adenylate cyclase: possible involvement of inhibitory guanine nucleotide regulatory protein.
Topics: Acrosin; Adenylyl Cyclase Inhibitors; Animals; Aorta; Cattle; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Endopeptidases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Male; Natriuretic Agents; Proteins; Rats; Thionucleotides | 1985 |
Multiple defects in the activity of adenylate cyclase from the Drosophila memory mutant rutabaga.
Topics: Abdomen; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Calcium; Colforsin; Diterpenes; Drosophila melanogaster; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Head; Memory; Mutation; Octopamine; Thionucleotides; Thorax | 1985 |
Defective responsiveness of adenylate cyclase to forskolin in the Drosophila memory mutant rutabaga.
Topics: Adenylyl Cyclases; Animals; Chromosome Mapping; Colforsin; Drosophila melanogaster; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Magnesium; Membranes; Memory; Octopamine; Sodium Fluoride; Thionucleotides; Trifluoperazine | 1985 |
Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adipose Tissue; Animals; Bacterial Proteins; Cell Membrane; Colforsin; Diterpenes; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Male; Nicotinic Acids; Pertussis Toxin; Phosphoric Monoester Hydrolases; Rats; Sodium Chloride; Thionucleotides; Virulence Factors, Bordetella | 1983 |
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Cell Line; Cell Membrane; Colforsin; Diterpenes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Lymphoma; Mice; Molecular Weight; Mutation; Receptors, Cell Surface; Somatostatin; Thionucleotides | 1984 |
Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Cholesterol; Colforsin; Detergents; Dimyristoylphosphatidylcholine; Diterpenes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Liver; Macromolecular Substances; Phosphatidylcholines; Rabbits; Receptors, Cell Surface; Thermodynamics; Thionucleotides | 1982 |
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Antihypertensive Agents; Bacterial Toxins; Blood Platelets; Cell Membrane; Colforsin; Diterpenes; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Magnesium; Molecular Weight; Pertussis Toxin; Prostaglandins E; Receptors, Cell Surface; Sodium Fluoride; Thionucleotides; Virulence Factors, Bordetella | 1984 |
Regulation of adenylate cyclase of human platelet membranes by forskolin.
Topics: Adenylyl Cyclases; Adult; Alprostadil; Antihypertensive Agents; Blood Platelets; Cell Membrane; Cholera Toxin; Colforsin; Diterpenes; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Kinetics; Male; Prostaglandins E; Sodium Fluoride; Thionucleotides | 1982 |
Beta-adrenergic and cholinergic modulation of inward rectifier K+ channel function and phosphorylation in guinea-pig ventricle.
Topics: Acetylcholine; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Ethers, Cyclic; Ganglia, Parasympathetic; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoproterenol; Okadaic Acid; Patch-Clamp Techniques; Pertussis Toxin; Phosphoprotein Phosphatases; Phosphorylation; Potassium Channels; Receptors, Adrenergic, beta; Sympathomimetics; Virulence Factors, Bordetella | 1995 |
Effect of PT-treatment on ANP-mediated inhibition of adenylate cyclase and amylase release in rat parotid gland.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amylases; Animals; Atrial Natriuretic Factor; Colforsin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Male; Parotid Gland; Pertussis Toxin; Rats; Rats, Wistar; Receptors, Atrial Natriuretic Factor; Virulence Factors, Bordetella | 1994 |
Olfactory transduction mechanisms in sheep.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Epithelium; Ethylamines; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Inositol Phosphates; Kinetics; Odorants; Olfactory Mucosa; Sheep; Signal Transduction; Smell | 1995 |
GTP requirement for isoproterenol activation of calcium channels in vascular myocytes.
Topics: Animals; Calcium Channels; Colforsin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Isoproterenol; Male; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Rabbits; Thionucleotides | 1995 |
Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Base Sequence; Benzoxazines; Binding, Competitive; Calcium; Cations, Divalent; Cations, Monovalent; Cell Line; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Morpholines; Naphthalenes; Pertussis Toxin; Receptors, Cannabinoid; Receptors, Drug; Serum Albumin; Signal Transduction; Virulence Factors, Bordetella | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Chloride channels in myocytes from rabbit colon are regulated by a pertussis toxin-sensitive G protein.
Topics: Animals; Bucladesine; Calcimycin; Cell Adhesion; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Colon; Cytosol; Diglycerides; Electric Conductivity; Electrophysiology; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Ion Channels; Ionomycin; Male; Meglumine; Membrane Potentials; Membrane Proteins; Muscle, Smooth; NAD; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Virulence Factors, Bordetella | 1993 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Studies on the action of thyroid stimulation blocking antibody (TSBAb) on thyroid cell membrane.
Topics: Animals; Cell Membrane; Colforsin; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Immunoglobulins, Thyroid-Stimulating; Long-Acting Thyroid Stimulator; Swine; Thyroid Gland; Thyrotropin | 1994 |
G-protein regulation of capacitative calcium entry may be mediated by protein kinases A and C in Xenopus oocytes.
Topics: Adenylyl Cyclases; Aluminum Compounds; Animals; Calcium; Chloride Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Enzyme Activation; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Oocytes; Protein Kinase C; Tetradecanoylphorbol Acetate; Type C Phospholipases; Xenopus laevis | 1995 |
Effects of transforming growth factor beta 1 on the adenylyl cyclase-cAMP pathway in prostate cancer.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cell Division; Cell Line; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Phenotype; Prostatic Neoplasms; Rats; Transforming Growth Factor beta; Tumor Cells, Cultured | 1994 |
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Base Sequence; Colforsin; Cyclic AMP; Cytoplasm; Enzyme Activation; Escherichia coli; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Sequence Data; Solubility; Transformation, Genetic | 1995 |
Calcium current in rat diabetic ventricular myocytes.
Topics: Action Potentials; Animals; Blood Glucose; Body Weight; Calcium Channels; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Electric Conductivity; Guanosine 5'-O-(3-Thiotriphosphate); Heart; Heart Ventricles; Isoproterenol; Kinetics; Male; Myocardial Contraction; Rats; Rats, Wistar | 1994 |
Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes.
Topics: Adenylyl Cyclase Inhibitors; Aldehydes; Animals; Ca(2+) Mg(2+)-ATPase; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney Cortex; Liver; Thyroid Gland; Thyrotropin | 1994 |
Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms.
Topics: Adenylyl Imidodiphosphate; Adrenergic beta-Agonists; Animals; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Horses; Ion Channel Gating; Isoproterenol; Kinetics; Membrane Potentials; Muscle, Smooth; Potassium Channels; Trachea | 1994 |
All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Pertussis Toxin; Radioligand Assay; Receptors, Somatostatin; Recombinant Proteins; Signal Transduction; Somatostatin; Somatostatin-28; Transfection; Virulence Factors, Bordetella | 1994 |
Augmented agonist-induced Ca(2+)-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells.
Topics: Actin Cytoskeleton; Animals; Calcium; Cell Membrane Permeability; Colforsin; Coronary Vessels; Escin; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Signal Transduction | 1994 |
Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS 201-995.
Topics: Animals; Binding, Competitive; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Electrochemistry; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Octreotide; Rats; Receptors, Somatostatin; Somatostatin; Virulence Factors, Bordetella | 1994 |
Modulation of cardiac L-type Ca2+ channels by GTP gamma S in response to isoprenaline, forskolin and photoreleased nucleotides.
Topics: Animals; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Isoproterenol; Myocardium; Photolysis; Protein Kinase Inhibitors; Thionucleotides | 1994 |
Alteration in Gs-mediated signal transduction in S49 lymphoma cells treated with inhibitors of microtubules.
Topics: Adenylyl Cyclases; Catalysis; Cholera Toxin; Colchicine; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Lymphoma; Microtubules; Signal Transduction; Somatostatin; Tumor Cells, Cultured; Vinblastine | 1993 |
Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims.
Topics: Adenylyl Cyclases; Adolescent; Adult; Aged; Blotting, Western; Colforsin; Depressive Disorder; Electrophoresis, Polyacrylamide Gel; Female; Frontal Lobe; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Nerve Tissue Proteins; Suicide; Synaptic Membranes | 1994 |
Production of thyroid stimulation blocking antibody without TSH receptor binding activity in rabbits with experimental autoimmune thyroiditis.
Topics: Adenylyl Cyclases; Animals; Autoantibodies; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoglobulin G; Rabbits; Receptors, Thyrotropin; Sodium Fluoride; Swine; Thyroglobulin; Thyroid Gland; Thyroiditis, Autoimmune; Thyrotropin | 1994 |
5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition.
Topics: 3T3 Cells; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Clone Cells; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; Humans; Kinetics; Male; Mice; Molecular Sequence Data; Moths; Peptide Fragments; Pertussis Toxin; Protein Structure, Secondary; Rats; Rats, Wistar; Receptors, Serotonin; Virulence Factors, Bordetella | 1994 |
Intraventricular injection of agents that enhance cyclic adenosine monophosphate formation leads to inhibition of proestrous luteinizing hormone surge in rats.
Topics: Animals; Bucladesine; Colforsin; Cyclic AMP; Female; GABA Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Immune Sera; Injections, Intraventricular; Luteinizing Hormone; Proestrus; Rats; Rats, Wistar; Serotonin | 1993 |
Naltrexone-induced upregulation of mu opioid receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Membrane; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Naltrexone; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 1993 |
Forskolin inhibition of K+ current in pregnant rat uterine smooth muscle cells.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Dose-Response Relationship, Drug; Electrophysiology; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Myometrium; Potassium Channels; Pregnancy; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Thionucleotides; Uterine Contraction | 1993 |
Regulation of Ca2+ current in frog ventricular cardiomyocytes by guanosine 5'-triphosphate analogues and isoproterenol.
Topics: Acetylcholine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Animals; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Heart; In Vitro Techniques; Isoproterenol; Myocardium; Rana catesbeiana | 1993 |
Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Base Sequence; Colforsin; Cyclic AMP; DNA Primers; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Sequence Data; PC12 Cells; Phenethylamines; Rats; Receptors, Purinergic P1 | 1993 |
Separate GTP binding and GTPase activating domains of a G alpha subunit.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Cell Line; Colforsin; Cyclic AMP; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Kinetics; Molecular Sequence Data; Mutation; Protein Conformation | 1993 |
Inhibition of adenylyl cyclase by Gi alpha.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calmodulin; Cell Line; Colforsin; Dose-Response Relationship, Drug; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Moths; Myristic Acid; Myristic Acids; Recombinant Proteins | 1993 |
Regional distribution of guanine nucleotide binding proteins (Gs and Gi alpha) in human brain: correlation with adenylyl cyclase activity.
Topics: Adenylyl Cyclases; Adult; Aged; Brain; Colforsin; Cyclic AMP; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoblotting; Male; Middle Aged; Tissue Distribution | 1993 |
Rate-limiting steps in the beta-adrenergic stimulation of cardiac calcium current.
Topics: Acetylcholine; Animals; Calcium Channels; Colforsin; Cyclic AMP; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart; Hot Temperature; In Vitro Techniques; Isoproterenol; Kinetics; Myocardium; Photolysis; Propranolol; Rana catesbeiana; Rana esculenta; Receptors, Adrenergic, beta; Sympathetic Nervous System | 1993 |
Adenylate cyclase activity in microdissected rat liver tissue: periportal to pericentral activity gradient.
Topics: Adenylyl Cyclases; Angiotensin II; Animals; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Glucagon; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Lithium; Lithium Chloride; Liver; Male; Rats; Rats, Sprague-Dawley; Sodium Fluoride | 1993 |
Coupling of adenosine receptors to adenylate cyclase in postischemic rat brain.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; Brain Ischemia; Calcium; Colforsin; Cyclic AMP; Down-Regulation; Edetic Acid; Egtazic Acid; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heart Arrest; Male; Models, Biological; Rats; Rats, Wistar; Receptors, Purinergic; Signal Transduction | 1993 |
Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder.
Topics: Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Bipolar Disorder; Cerebral Cortex; Colforsin; Cyclic AMP; Electrophoresis; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoblotting; Male; Middle Aged; Tissue Distribution | 1993 |
Opposing influences of dexamethasone and retinoic acid on adenylate cyclase activity in ROS 17/2.8 cells.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Amino Acid Sequence; Blotting, Northern; Cell Membrane; Colforsin; Dexamethasone; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Isoproterenol; Molecular Sequence Data; Osteosarcoma; RNA, Messenger; Sodium Fluoride; Tretinoin; Tumor Cells, Cultured | 1993 |
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Brain; Cell Membrane; Cerebellum; Colforsin; Corticotropin-Releasing Hormone; Ethanol; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Mice; Mice, Mutant Strains; Pertussis Toxin; Signal Transduction; Virulence Factors, Bordetella | 1993 |
Vip-induced cross-talk between G-proteins in membranes from rat anterior pituitary cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Binding Sites; Cell Membrane; Cells, Cultured; Cholera Toxin; Colforsin; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Magnesium; Models, Biological; Pertussis Toxin; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1993 |
Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate.
Topics: 3T3 Cells; Adenylate Cyclase Toxin; Animals; Calcium; Cells, Cultured; Chlorocebus aethiops; CHO Cells; Colforsin; Cricetinae; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Humans; Ion Channel Gating; Lysophospholipids; Mice; Pertussis Toxin; Potassium Channels; Rats; Receptors, Cell Surface; Receptors, Muscarinic; Signal Transduction; Sphingosine; Virulence Factors, Bordetella | 1996 |
Adenylyl cyclase activity in turtle vomeronasal and olfactory epithelium.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Epithelium; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Nose; Odorants; Receptors, Odorant; Signal Transduction; Smell; Turtles | 1996 |
A G protein, not cyclic AMP, mediates effects of VIP on the inwardly rectifying K+ channels in endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Endothelium, Vascular; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Isoproterenol; Norepinephrine; Pertussis Toxin; Potassium Channels; Thionucleotides; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1996 |
Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Bucladesine; Cell-Free System; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Okadaic Acid; PC12 Cells; Protein Kinase C; Protein Processing, Post-Translational; Rats | 1996 |
Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation.
Topics: Adenylyl Cyclases; Animals; Antibodies; Carbachol; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol 1,4,5-Trisphosphate; Isoproterenol; Kinetics; Muscarinic Agonists; Phosphoric Diester Hydrolases; Receptors, Muscarinic; Recombinant Proteins; Transfection | 1996 |
Purification and characterization of a soluble form of mammalian adenylyl cyclase.
Topics: Adenoviridae; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chromatography, Ion Exchange; Colforsin; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; Protease Inhibitors; Rats; Solubility; Substrate Specificity | 1996 |
Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells. Purification and biochemical characterization.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cations, Divalent; Colforsin; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Mercaptoethanol; Molecular Weight; Osmolar Concentration; Oxidation-Reduction; Spodoptera | 1996 |
Characterization of adenylyl cyclase stimulated by VIP in rat and mouse peritoneal macrophage membranes.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Cell Membrane; Cholera Toxin; Colforsin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Intercellular Signaling Peptides and Proteins; Kinetics; Macrophages, Peritoneal; Mice; NAD; Neuropeptides; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; Secretin; Sodium Fluoride; Vasoactive Intestinal Peptide | 1996 |
Triiodothyronine regulates beta 3-adrenoceptor expression in 3T3-F442A differentiating adipocytes.
Topics: 3T3 Cells; Adenylyl Cyclases; Adipocytes; Adrenergic beta-Antagonists; Animals; Base Sequence; Cell Differentiation; Cell Nucleus; Colforsin; Dactinomycin; DNA Primers; Gene Expression; Glycerolphosphate Dehydrogenase; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Kinetics; Mice; Molecular Sequence Data; Propanolamines; Protein Biosynthesis; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triiodothyronine | 1996 |
Pretreatment with 17 beta-estradiol attenuates basal- and PTH-stimulated membrane adenylyl cyclase activity in human osteoblast-like SAOS-2 cells.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Estradiol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Manganese; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Phosphorus Radioisotopes; Teriparatide; Time Factors | 1996 |
Pharmacological analysis of dopamine stimulation of [35S]-GTP gamma S binding via human D2short and D2long dopamine receptors expressed in recombinant cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombination, Genetic; Stimulation, Chemical | 1996 |
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Topics: Adenylyl Cyclases; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Solubility | 1996 |
In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Baculoviridae; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Spodoptera | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Membrane Proteins; Norepinephrine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Signal Transduction; Tritium | 1997 |
Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype.
Topics: Animals; Arginine; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Guanosine 5'-O-(3-Thiotriphosphate); Hydrogen Bonding; Mice; Mutagenesis, Site-Directed; Mutation; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Recombinant Proteins | 1997 |
cAMP-dependent protein kinase modulates expiratory neurons in vivo.
Topics: Animals; Cats; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Iontophoresis; Male; Medulla Oblongata; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phrenic Nerve; Receptors, Serotonin; Respiratory Mechanics; Serotonin Receptor Agonists; Synaptic Membranes | 1997 |
Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine | 1997 |
Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor.
Topics: Adenosine; Adenosine Deaminase; Allosteric Regulation; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Recombinant Proteins; Thiophenes; Xanthines | 1997 |
GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls.
Topics: Adenylyl Cyclases; Adolescent; Adult; Aged; Antidepressive Agents; Brain; Cadaver; Colforsin; Depression; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Signal Transduction; Suicide | 1996 |
The roles of adenosine 3',5'-cyclic monophosphate-dependent protein kinase A and protein kinase C in stimulus-secretion coupling in AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cell Line; Cell Membrane Permeability; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Intercellular Signaling Peptides and Proteins; Mice; Peptides; Pituitary Gland, Anterior; Protein Kinase C; Tetradecanoylphorbol Acetate; Wasp Venoms | 1996 |
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study.
Topics: Animals; Binding, Competitive; Chickens; Colforsin; Cyclic AMP; Drug Design; Guanosine 5'-O-(3-Thiotriphosphate); Melatonin; Models, Molecular; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Superior Colliculi | 1997 |
1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues.
Topics: Animals; Binding Sites; Binding, Competitive; Chickens; Colforsin; Cyclic AMP; Drug Design; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Melatonin; Models, Chemical; Quail; Superior Colliculi | 1997 |
Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Colforsin; Consensus Sequence; Cyclic AMP; Drosophila melanogaster; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Mammals; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Sequence Alignment | 1997 |
Impairment of muscarinic stimulation of adenylyl cyclase by heparin in rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Carbachol; Colforsin; Corpus Striatum; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heparin; In Vitro Techniques; Kinetics; Male; Muscarinic Agonists; N-Methylscopolamine; Olfactory Bulb; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives | 1997 |
Molecular characterization and functional expression of opioid receptor-like1 receptor.
Topics: Adenylyl Cyclase Inhibitors; Animals; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Gene Expression; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen-Ion Concentration; Ligands; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 1997 |
Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase.
Topics: Adenylyl Cyclases; Binding Sites; Centrifugation; Chromatography, Gel; Colforsin; Cytosol; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Weight; Protein Conformation | 1997 |
Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Aluminum Compounds; Animals; Binding, Competitive; Bisoprolol; Colforsin; Enzyme Activation; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Myocardium; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, beta; Swine | 1998 |
Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor.
Topics: Adenylyl Cyclases; Alkylation; Animals; Cell Membrane; CHO Cells; Clozapine; Colforsin; Corpus Striatum; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Muscarinic Antagonists; N-Methylscopolamine; Protein Binding; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptosomes | 1997 |
Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Aged; Blotting, Western; Carcinoma, Hepatocellular; Colforsin; Densitometry; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Liver; Liver Neoplasms; Male; Middle Aged; Pertussis Toxin; Reference Values; Virulence Factors, Bordetella | 1997 |
Chemosignal transduction in the vomeronasal organ of garter snakes: Ca(2+)-dependent regulation of adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Calcium; Chemotactic Factors; Colforsin; Colubridae; Electroshock; Epithelial Cells; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Magnesium; Models, Biological; Odorants; Oligochaeta; Sensory Receptor Cells; Signal Transduction; Virulence Factors, Bordetella; Vomeronasal Organ | 1997 |
Adenylyl cyclase signal transduction and alcohol-induced sedation.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alcohol Drinking; Animals; Brain; Central Nervous System Depressants; Colforsin; Drug Tolerance; Enzyme Inhibitors; Ethanol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoblotting; Postural Balance; Rats; Rats, Inbred Strains; Signal Transduction; Sleep | 1997 |
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Binding Sites; Catalysis; Colforsin; Crystallization; Crystallography, X-Ray; Dimerization; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary | 1997 |
Protein kinase A regulates the disposition of Ca2+ which enters the cytoplasmic space through store-activated Ca2+ channels in rat hepatocytes by diverting inflowing Ca2+ to mitochondria.
Topics: Adenosine Triphosphate; Aluminum Compounds; Animals; Bucladesine; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Enzyme Inhibitors; Fluorides; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Liver; Mitochondria, Liver; Rats; Thapsigargin; Vasopressins | 1998 |
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
Topics: Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclopropanes; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Protein Binding; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sulfur Radioisotopes; Transfection; Tritium | 1998 |
The oxytocin-induced inward current in vagal neurons of the rat is mediated by G protein activation but not by an increase in the intracellular calcium concentration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain Stem; Buffers; Calcium; Colforsin; Cyclic AMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; N-Methylaspartate; Neurons; Oxytocin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Thionucleotides; Vagus Nerve | 1997 |
Calcium channel current facilitation in porcine adrenal chromaffin cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Animals; Barium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chromaffin System; Colforsin; Electric Conductivity; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; omega-Conotoxin GVIA; Peptides; Swine; Thionucleotides | 1998 |
Inhibition of adenylyl cyclase by caveolin peptides.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Caveolin 1; Caveolins; Colforsin; Enzyme Inhibitors; Gene Deletion; Guanosine 5'-O-(3-Thiotriphosphate); Isoenzymes; Kinetics; Membrane Proteins; Mice; Mutagenesis; Peptide Fragments; Point Mutation; Structure-Activity Relationship | 1998 |
Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Animals; Antihypertensive Agents; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Down-Regulation; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Opioid, kappa | 1998 |
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Kinetics; Mice; N-Methylaspartate; Narcotic Antagonists; Neuroblastoma; Neurons; Nociceptin; Nociceptin Receptor; Opioid Peptides; Rats; Receptors, Opioid; Signal Transduction | 1998 |
Differential regulation of N- and Q-type Ca2+ channels by cyclic nucleotides and G-proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Nucleotides, Cyclic; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphodiesterase Inhibitors; Xenopus | 1998 |
Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Colforsin; Cyclic AMP; Cyclohexanols; Dronabinol; Gene Expression Regulation, Developmental; Gestational Age; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Morpholines; Naphthalenes; Neuroglia; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Signal Transduction | 1998 |
A [35S]GTPgammaS binding assessment of metabotropic glutamate receptor standards in Chinese hamster ovary cell lines expressing the human metabotropic receptor subtypes 2 and 4.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Metabotropic Glutamate; Sulfur Radioisotopes | 1998 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
Heterotrimeric G-protein candidates for Ge in the ACTH secretory pathway.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Intercellular Signaling Peptides and Proteins; Macromolecular Substances; Male; Mice; Peptides; Pertussis Toxin; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Rats, Sprague-Dawley; Somatostatin; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wasp Venoms | 1998 |
Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Angiotensin II; Animals; Aorta; Atrial Natriuretic Factor; Autoradiography; Blotting, Northern; Colforsin; Desoxycorticosterone; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hypertension; Immunoblotting; Isoproterenol; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sarcolemma; Sodium Chloride; Time Factors | 1998 |
Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy.
Topics: Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Receptors, Opioid; Tumor Cells, Cultured | 1998 |
Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells.
Topics: Animals; Cell Survival; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Kinetics; Phosphatidylinositols; Pyrrolidinones; Receptors, Purinergic P1; Recombinant Proteins; Signal Transduction; Transfection; Type C Phospholipases; Xanthines | 1998 |
Long-lasting effects of chronic mu-opioid intake on the signal transmission via dopamine D1 receptors in the limbic forebrain of drug deprived rats.
Topics: Adenylyl Cyclase Inhibitors; Administration, Oral; Animals; Benzimidazoles; Colforsin; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Male; Narcotics; Nucleus Accumbens; Olfactory Bulb; Phenanthridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, mu; Self Administration; Signal Transduction; Time Factors | 1998 |
Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Artemisia; Behavior, Animal; Bicyclic Monoterpenes; Binding, Competitive; Brain Chemistry; Cannabinoids; Colforsin; Cyclohexanols; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Monoterpenes; Palatine Tonsil; Plants, Medicinal; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Terpenes | 1999 |
Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hyperalgesia; Inflammation; Loperamide; Male; Mice; Mice, Inbred ICR; Pain Measurement; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630.
Topics: Animals; Benzoxazines; Binding, Competitive; Camphanes; Cannabinoids; CHO Cells; Chromans; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Morpholines; Naphthalenes; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Tritium | 1999 |
Design and models for estimating antagonist potency (pA2, Kd and IC50) following the detection of antagonism observed in the presence of intrinsic activity.
Topics: Amino Acids, Dicarboxylic; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Gene Library; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Kinetics; Models, Neurological; Models, Statistical; Neuroprotective Agents; Organization and Administration; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sulfur Radioisotopes; Transfection | 1999 |
Angiotensin II enhances the expression of Gialpha in A10 cells (smooth muscle): relationship with adenylyl cyclase activity.
Topics: Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angiotensin II; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cell Line; Colforsin; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Muscle, Smooth, Vascular; Peptide Fragments; Protein Kinase C; Rats; Staurosporine | 1999 |
[Phe1phi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as a partial agonist at ORL1 receptor endogenously expressed in mouse N1E-115 neuroblastoma cells.
Topics: Animals; Colforsin; Cyclic AMP; Drug Combinations; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Receptors, Opioid; Tumor Cells, Cultured | 1999 |
Lack of involvement of G proteins in the activation of cardiac CFTR Cl- current by genistein.
Topics: Adenylate Cyclase Toxin; Animals; Calcium Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guinea Pigs; Heart; Isoproterenol; Pertussis Toxin; Protein-Tyrosine Kinases; Sympathomimetics; Thionucleotides; Virulence Factors, Bordetella | 1999 |
F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.
Topics: Animals; Carotid Arteries; Colforsin; Cyclic AMP; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart; Hemodynamics; Humans; Hypothermia; In Vitro Techniques; Male; Migraine Disorders; Muscle, Smooth, Vascular; Neurons; Nitriles; Piperazines; Rabbits; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Saphenous Vein; Swine; Trigeminal Ganglion; Tryptamines | 1999 |
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Calcium; Cell Line; Cell Membrane; Chemokine CCL5; Chemotaxis; Cloning, Molecular; Colforsin; Cyclic AMP; Evolution, Molecular; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Models, Molecular; Molecular Sequence Data; Pertussis Toxin; Protein Structure, Secondary; Receptors, CCR5; Receptors, CXCR4; Recombinant Proteins; Sequence Alignment; Transfection; Virulence Factors, Bordetella | 1999 |
Efficient functional coupling of the human D3 dopamine receptor to G(o) subtype of G proteins in SH-SY5Y cells.
Topics: Adenylyl Cyclases; Binding, Competitive; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Membrane Potentials; Quinpirole; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sulfur Radioisotopes; Tritium; Tumor Cells, Cultured | 1999 |
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics, Opioid; Animals; Base Sequence; Benzeneacetamides; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Corpus Striatum; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Pyrrolidines; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 1999 |
Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cricetinae; Cricetulus; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lung; Radioligand Assay; Receptors, Somatostatin; Recombinant Proteins; Somatostatin; Transfection | 1999 |
Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Colforsin; Cricetinae; Cricetulus; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lung; Pertussis Toxin; Phosphatidylinositols; Radioligand Assay; Receptors, Somatostatin; Recombinant Proteins; Somatostatin; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Altered expression of Gi-protein and adenylyl cyclase activity in hearts from one kidney one clip hypertensive rats: effect of captopril.
Topics: Adenylyl Cyclases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Colforsin; Glucagon; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension, Renovascular; Isoproterenol; Myocardium; Rats; Rats, Sprague-Dawley | 1999 |
A Ras-dependent chloride current activated by adrenocorticotropin in rat adrenal zona glomerulosa cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Aldosterone; Animals; Cells, Cultured; Chloride Channels; Colforsin; Cyclic AMP; Female; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Oligopeptides; Patch-Clamp Techniques; Proto-Oncogene Proteins p21(ras); Rats; Rats, Long-Evans; Zona Glomerulosa | 2000 |
A calcium-inhibited Drosophila adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alternative Splicing; Animals; Blotting, Northern; Calcium; Cell Membrane; Central Nervous System; Cloning, Molecular; Colforsin; Drosophila melanogaster; Enzyme Activation; Gene Expression Regulation; Gene Library; Guanosine 5'-O-(3-Thiotriphosphate); Immunohistochemistry; Models, Genetic; Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2000 |
Galanin inhibits acetylcholine release from rat cerebral cortex via a pertussis toxin-sensitive G(i)protein.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Brain Chemistry; Cerebral Cortex; Colforsin; Cyclic AMP; Drug Synergism; Galanin; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Peptide Fragments; Pertussis Toxin; Potassium; Rats; Stimulation, Chemical; Substance P; Sulfur Radioisotopes; Synaptosomes; Tritium; Virulence Factors, Bordetella | 1999 |
Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations.
Topics: Animals; Animals, Newborn; Autoradiography; Colforsin; DNA Primers; Dose-Response Relationship, Drug; Female; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Islets of Langerhans; Male; Melatonin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tryptamines | 2000 |
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.
Topics: Animals; Cell Membrane; Cerebral Cortex; CHO Cells; Colforsin; Corpus Striatum; Cricetinae; Cyclic AMP; Dimerization; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Ligands; Male; Neurons; Pyramidal Cells; Quinpirole; Rats; Receptor Cross-Talk; Receptors, Dopamine D2; Receptors, Somatostatin; Somatostatin; Spiperone; Sulpiride; Transfection | 2000 |
A guanylyl cyclase from Paramecium with 22 transmembrane spans. Expression of the catalytic domains and formation of chimeras with the catalytic domains of mammalian adenylyl cyclases.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Catalytic Domain; Colforsin; Escherichia coli; Guanosine 5'-O-(3-Thiotriphosphate); Guanylate Cyclase; Molecular Sequence Data; Mutagenesis, Site-Directed; Paramecium; Recombinant Fusion Proteins; Structure-Activity Relationship; Substrate Specificity | 2000 |
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Drug Antagonism; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Insecta; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Sulfur Radioisotopes; Transfection | 2000 |
A possible role for caveolin as a signaling organizer in olfactory sensory membranes.
Topics: Animals; Caveolin 1; Caveolin 2; Caveolins; Cell Fractionation; Cilia; Colforsin; Cyclic AMP; Female; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Male; Membrane Proteins; Microvilli; Odorants; Olfactory Mucosa; Peptide Fragments; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Odorant; Second Messenger Systems; Signal Transduction; Vomeronasal Organ | 2000 |
Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor.
Topics: Animals; Binding, Competitive; Calcium; Cells, Cultured; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA-Binding Proteins; DNA, Complementary; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Nuclear Proteins; Pertussis Toxin; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Serum Response Factor; Spiperone; Sulfur Radioisotopes; Transfection; Tritium; Virulence Factors, Bordetella | 2000 |
Signal transduction characteristics of the corticotropin-releasing hormone receptors in the feto-placental unit.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Amino Acid Sequence; Binding Sites; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Extraembryonic Membranes; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Inositol Phosphates; Molecular Sequence Data; Placenta; Pregnancy; Receptors, Corticotropin-Releasing Hormone; Signal Transduction; Virulence Factors, Bordetella | 2000 |
Adenylyl cyclase regulates signal onset via the inhibitory GTP-binding protein, Gi.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Mice; Molecular Mimicry; Receptor, Muscarinic M4; Receptors, Muscarinic; Signal Transduction; Somatostatin; Tumor Cells, Cultured | 2000 |
Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle.
Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Detergents; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; MAP Kinase Signaling System; Muscle Proteins; Muscle, Smooth; Myosin-Light-Chain Kinase; Octoxynol; Peptide Fragments; Peptides; Phosphorylation; Point Mutation; Portal Vein; Protein Kinases; Rabbits; Recombinant Proteins; Serine Endopeptidases; Time Factors | 2000 |
Species differences in the efficacy of compounds at the nociceptin receptor (ORL1).
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; DNA, Complementary; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inhibitory Concentration 50; Kinetics; Mice; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Peptide Fragments; Peptides; Protein Binding; Receptors, Opioid; Species Specificity; Transfection | 2000 |
Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart.
Topics: Adenylyl Cyclases; Animals; Aorta, Thoracic; Arteriovenous Shunt, Surgical; Blood Pressure; Blotting, Northern; Body Weight; Cardiomegaly; Colforsin; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Male; Myocardium; Organ Size; Protein Isoforms; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Fluoride | 2000 |
Decreased adenylyl cyclase protein and function in airway smooth muscle by chronic carbachol pretreatment.
Topics: Adenylyl Cyclases; Aluminum; Animals; Atropine; Carbachol; Cattle; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Down-Regulation; Enzyme Activation; Erythrocytes; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunoblotting; Mice; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Radioligand Assay; Sodium Fluoride; Time; Trachea | 2000 |
Ouabain-insensitive Na(+)-ATPase activity is an effector protein for cAMP regulation in basolateral membranes of the proximal tubule.
Topics: Adenosine Triphosphatases; Animals; Cation Transport Proteins; Cholera Toxin; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kidney Tubules, Proximal; Ouabain; Swine | 2000 |
Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor.
Topics: Adenylyl Cyclases; Animals; Baclofen; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; GABA Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Presynaptic; Sodium Oxybate; Subcellular Fractions | 2000 |
The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states.
Topics: Animals; Binding, Competitive; Chemokine CXCL12; Chemokines, CXC; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Jurkat Cells; Leukocytes, Mononuclear; Pertussis Toxin; Receptors, CXCR4; Signal Transduction; T-Lymphocytes; Virulence Factors, Bordetella | 2000 |
Characterization of [3H]CGP 12177 binding to beta-adrenergic receptors in intact eel hepatocytes.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Alprenolol; Anguilla; Animals; Atenolol; Binding Sites; Binding, Competitive; Butoxamine; Cell Count; Colforsin; Cyclic AMP; Epinephrine; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Hepatocytes; Kinetics; Propanolamines; Propranolol; Receptors, Adrenergic, beta; Tritium | 2001 |
Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist.
Topics: Acetic Acid; Adenylyl Cyclase Inhibitors; Analgesics, Opioid; Animals; Buprenorphine; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Narcotic Antagonists; Nociceptin Receptor; Pain Measurement; Receptors, Opioid | 2001 |
Functional characterization of a human receptor for neuropeptide FF and related peptides.
Topics: Aequorin; Animals; Binding, Competitive; Calcium; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Gene Expression Profiling; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Oligopeptides; Pertussis Toxin; Receptors, Neuropeptide; RNA, Messenger; Substrate Specificity; Thermodynamics; Virulence Factors, Bordetella | 2001 |
Inhibition of adenylyl cyclase activity in brain membrane fractions by arachidonic acid and related unsaturated fatty acids.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arachidonic Acid; Brain Chemistry; Cations, Divalent; Cell Membrane; Cerebellum; Cerebral Cortex; Colforsin; Corpus Striatum; Diglycerides; Dose-Response Relationship, Drug; Fatty Acids; Fatty Acids, Unsaturated; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mice; Mice, Inbred ICR; Phospholipids; Subcellular Fractions; Substrate Specificity; Temperature; Thionucleotides | 2001 |
[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor.
Topics: Amino Acid Sequence; Animals; Brain; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypothalamic Hormones; Iodine Radioisotopes; Kinetics; Ligands; Melanins; Molecular Sequence Data; Oligopeptides; Pituitary Hormones; Protein Binding; Radioligand Assay; Receptors, Pituitary Hormone; Substrate Specificity; Thermodynamics | 2001 |
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Antidepressive Agents; Binding, Competitive; Buspirone; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Male; Motor Activity; Piperazines; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2001 |
Dual coupling of opioid receptor-like (ORL1) receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Colforsin; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanosine 5'-O-(3-Thiotriphosphate); Isoenzymes; Male; Nociceptin; Nociceptin Receptor; Olfactory Bulb; Opioid Peptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Sulfur Radioisotopes; Tritium; Vasodilator Agents | 2001 |
Impaired beta-adrenergic signaling pathway in white adipocytes of suckling fa/fa Zucker rats: a defect in receptor coupling.
Topics: Adenylyl Cyclases; Adipocytes; Animals; Animals, Newborn; Blotting, Western; Catecholamines; Colforsin; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Male; Obesity; Rats; Rats, Zucker; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2001 |
Impaired parasympathetic heart rate control in mice with a reduction of functional G protein betagamma-subunits.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Cardiotonic Agents; Cell Membrane; Colforsin; Consciousness; Cyclic AMP; Cytosol; Electrocardiography; Electrophysiology; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Heart Rate; Heterotrimeric GTP-Binding Proteins; Isoproterenol; Mice; Mice, Transgenic; Parasympathetic Nervous System; Propranolol; Sinoatrial Node; Transgenes; Vagus Nerve; Vasodilator Agents | 2002 |
Identification and properties of a Gs protein in catfish liver membranes.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Colforsin; Dose-Response Relationship, Drug; Epinephrine; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hepatocytes; Ictaluridae; In Vitro Techniques; Kinetics; Ligands; Liver; Membranes; Thionucleotides | 2002 |
Mechanisms of ligand binding and efficacy at the human D2(short) dopamine receptor.
Topics: Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Phenethylamines; Receptors, Dopamine D2; Structure-Activity Relationship; Substrate Specificity; Tetrahydronaphthalenes | 2002 |
Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein.
Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Enzyme Activation; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Models, Biological; Proto-Oncogene Proteins; Receptors, Adrenergic, beta-2; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Recombinant Fusion Proteins; Spodoptera | 2002 |
Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator.
Topics: Animals; Brain; Carrier Proteins; Cattle; Cell Line; Cell Membrane; Colforsin; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Isoproterenol; NAD; Neuroblastoma; Pertussis Toxin; Phosphorus Radioisotopes; Tumor Cells, Cultured | 2002 |
Different roles for Gi and Go proteins in modulation of adenylyl cyclase type-2 activity.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Idazoxan; Pertussis Toxin; Protein Kinase C; Receptors, Adrenergic, alpha-2; Signal Transduction; Spodoptera; Tetradecanoylphorbol Acetate | 2002 |
Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dynorphins; Etorphine; Flow Cytometry; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Phosphorylation; Receptors, Opioid, kappa | 2003 |
Molecular identification of nicotinic acid receptor.
Topics: Adipocytes; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; DNA, Complementary; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Molecular Sequence Data; Niacin; Open Reading Frames; Poly A; Pyrazines; Radioligand Assay; Rats; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution | 2003 |
Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dideoxyadenosine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Intercellular Signaling Peptides and Proteins; Isoenzymes; Male; Mice; Peptides; Receptors, Cell Surface; Signal Transduction; Sodium Fluoride; Sperm Capacitation; Spermatozoa; Thionucleotides; Wasp Venoms | 2003 |
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics | 2003 |
N-terminal modifications leading to peptide ORL1 partial agonists and antagonists.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Sulfur Radioisotopes | 2003 |
Down-regulation of rat brain adenosine A1 receptors at the end of pregnancy.
Topics: Adenosine; Adenylyl Cyclases; Aldehyde-Lyases; Animals; Antihypertensive Agents; Binding Sites; Blotting, Northern; Brain; Cell Membrane; Colforsin; Densitometry; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Immunoblotting; Phenethylamines; Pregnancy; Rats; Rats, Wistar; Receptor, Adenosine A1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium; Xanthines | 2004 |
Redox modulation of Gi protein expression and adenylyl cyclase signaling: role of nitric oxide.
Topics: Adenylyl Cyclases; Angiotensin II; Animals; Blood Pressure; Cholera Toxin; Colforsin; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heart; Male; Muscarinic Agonists; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Oxotremorine; Rats; Rats, Sprague-Dawley; Signal Transduction; Tissue Extracts | 2004 |
Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Cloning, Molecular; Colforsin; Cyclic AMP; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Morphine; Neuroblastoma; Oligonucleotides, Antisense; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2004 |
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Blood Pressure; Colforsin; Disease Models, Animal; Enzyme Inhibitors; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension; Losartan; Male; Models, Cardiovascular; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; RNA, Messenger; Sodium Fluoride; Statistics as Topic | 2004 |
"Low" concentrations of sodium fluoride inhibit neurotransmitter release from the guinea-pig superior cervical ganglion.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Calcium; Colforsin; Cyclic AMP; Depression, Chemical; Electric Stimulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Imidazoles; Imines; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Sodium Fluoride; Superior Cervical Ganglion | 2004 |
Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Exons; Gene Expression; Genome; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypothalamus; Inositol 1,4,5-Trisphosphate; Intracellular Signaling Peptides and Proteins; Introns; Ligands; Mice; Molecular Sequence Data; Neuropeptides; Orexin Receptors; Orexins; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; RNA, Messenger; Sequence Alignment; Tissue Distribution | 2004 |
Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.
Topics: Animals; Benzazepines; Blotting, Western; Cell Membrane; Colforsin; Cyclic AMP; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kidney Tubules, Proximal; Macrolides; Male; Microvilli; Precipitin Tests; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Second Messenger Systems; Signal Transduction; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase | 2004 |
Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Topics: Adenine; Animals; Brain; Cell Line, Tumor; Cell Membrane; Colforsin; Corpus Striatum; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Rats; Receptors, Purinergic; RNA, Messenger; Transcription, Genetic | 2005 |
Allosteric modulation of GABA(B) receptor function in human frontal cortex.
Topics: Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Calcium; Calcium Channel Blockers; Cell Membrane; Colforsin; Diphenhydramine; Dopamine Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine H1 Antagonists; Humans; Male; Middle Aged; Phenols; Prefrontal Cortex; Receptors, GABA-B; Trifluoperazine; Verapamil | 2005 |
Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Cell Line; Colforsin; Cricetinae; Cricetulus; Fibroblasts; Fishes; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Humans; Inositol Phosphates; Iodine Radioisotopes; Lung; Radioligand Assay; Receptors, Somatostatin; Somatostatin; Sulfur Isotopes; Type C Phospholipases | 2005 |
A "locked-on," constitutively active mutant of the adenosine A1 receptor.
Topics: Adenosine; Animals; Binding, Competitive; Cell Line; Cell Membrane; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Mutation; Plasmids; Radioligand Assay; Receptor, Adenosine A1; Sodium; Sulfur Radioisotopes; Theophylline; Thiophenes; Transfection; Tritium; Xanthines | 2005 |
17Beta-estradiol modulates hMT1 melatonin receptor function.
Topics: Analysis of Variance; Animals; Blotting, Northern; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Isotopes; Melatonin; Protein Binding; Radioligand Assay; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfur Isotopes; Time Factors | 2005 |
Stimulation of neuropeptide Y-mediated calcium responses in human SMS-KAN neuroblastoma cells endogenously expressing Y2 receptors by co-expression of chimeric G proteins.
Topics: Calcium; Cell Line, Tumor; Colforsin; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Neuroblastoma; Neuropeptide Y; Receptors, Neuropeptide Y; Recombinant Fusion Proteins | 2005 |
G-protein coupled activation of potassium channels by endogenous neuropeptides in snail neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetophenones; Animals; Antibodies; Blotting, Western; Cholera Toxin; Codeine; Colforsin; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Fishes; GTP-Binding Protein alpha Subunits; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Helix, Snails; Indomethacin; Membrane Potentials; Models, Neurological; Neurons; Neuropeptides; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channels; Signal Transduction; Suramin; Time Factors | 2005 |
Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm.
Topics: Adenylyl Cyclases; Alternative Splicing; Analgesics, Opioid; Animals; Base Sequence; Blotting, Northern; CHO Cells; Colforsin; Cricetinae; DNA Primers; Exons; Genetic Variation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Sequence Data; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells.
Topics: Adenylyl Cyclases; Angiotensin II; Cardiotonic Agents; Cells, Cultured; Colforsin; Dactinomycin; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoproterenol; Muscle, Smooth, Vascular; Parasympatholytics; RGS Proteins; Signal Transduction | 2005 |
Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Acetylcysteine; Adenylyl Cyclases; Animals; Antioxidants; Cells, Cultured; Colforsin; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension; Isoproterenol; MAP Kinase Signaling System; Models, Biological; Muscle, Smooth, Vascular; Onium Compounds; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Superoxides | 2005 |
Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aged; Alzheimer Disease; Cerebellum; Cerebral Cortex; Colforsin; Cyclic AMP; Down Syndrome; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Norepinephrine; Signal Transduction; Type C Phospholipases | 2006 |
Cell and tissue responses of a range of Urotensin II analogs at cloned and native urotensin II receptors. Evidence for coupling promiscuity.
Topics: Animals; Aorta, Thoracic; Calcium; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Recombinant Proteins; Urotensins | 2006 |
Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.
Topics: Animals; Cell Line; Chlorocebus aethiops; Colforsin; COS Cells; Dimerization; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Muscle, Smooth; Receptors, Adrenergic, beta-2; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Signal Transduction; Trachea | 2006 |
Enhanced expression of Gialpha protein and adenylyl cyclase signaling in aortas from 1 kidney 1 clip hypertensive rats.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Atrial Natriuretic Factor; Captopril; Colforsin; Dose-Response Relationship, Drug; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension, Renovascular; Immunoblotting; Isoproterenol; Peptide Fragments; Rats; Rats, Sprague-Dawley; Renal Artery Obstruction; Signal Transduction; Sodium Fluoride; Time Factors | 2006 |
In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
Topics: Animals; Benzoxazoles; Binding, Competitive; Brain; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lisuride; Male; Molecular Structure; Parkinson Disease; Piperazines; Quinpirole; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Fusion Proteins; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists | 2006 |
A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Drug Tolerance; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Furans; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Narcotic Antagonists; Opioid-Related Disorders; Pyrones; Radioligand Assay; Receptors, Opioid, mu | 2007 |
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.
Topics: Animals; Benzimidazoles; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cycloheptanes; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Narcotic Antagonists; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptosomes; Transfection; Vas Deferens | 2007 |
Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Colforsin; Cricetinae; Cricetulus; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Pertussis Toxin; Rats; Receptors, Neuropeptide Y; Swine | 2008 |
Effect of hydrogen peroxide on VIP-induced relaxation of the cat lower esophageal sphincter.
Topics: Animals; Cats; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Female; Guanosine 5'-O-(3-Thiotriphosphate); Hydrogen Peroxide; Male; Muscle Relaxation; Vasoactive Intestinal Peptide | 2007 |
Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cell Membrane; Colforsin; Cyclic AMP; Female; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Protein Binding; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Up-Regulation; Xanthines | 2008 |
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model.
Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Models, Biological; Mutant Proteins; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; RGS Proteins; Signal Transduction; Sulfur Radioisotopes | 2008 |
Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Amino Acids, Aromatic; Cell Line; Cell Membrane; Colforsin; Conserved Sequence; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Fluorescent Antibody Technique, Indirect; Genes, Reporter; Green Fluorescent Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Herpesvirus 4, Human; Humans; Hydrogen Bonding; Kidney; Luciferases; Lymphocytes; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Static Electricity; Transfection | 2008 |
Characterization of mouse heart adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Catalysis; Cations, Divalent; Cell Line; Cell Membrane; Colforsin; Enzyme Inhibitors; Female; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoenzymes; Isoproterenol; Kinetics; Metoprolol; Mice; Mice, Inbred Strains; Myocardium; Protein Isoforms; Receptors, G-Protein-Coupled; Recombinant Proteins; Spodoptera | 2009 |
Bradykinin inhibits the transient outward K+ current in mouse Schwann cells via the cAMP/PKA pathway.
Topics: Adamantane; Animals; Benzenesulfonates; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic CMP; Enzyme Activators; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Membrane Potentials; Mice; Mice, Inbred ICR; Potassium; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Schwann Cells; Sciatic Nerve; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Topics: Adenylyl Cyclases; Adult; Central Nervous System Agents; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Epilepsy, Temporal Lobe; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Neocortex; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Sulfur Radioisotopes; Temporal Lobe; Tritium; Young Adult | 2009 |
Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Digitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Protein Binding; Rats; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2010 |
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.
Topics: Analgesics, Opioid; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Endocytosis; Etorphine; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Opioid-Related Disorders; Receptors, Opioid, mu | 2010 |
Intracellular cAMP assay and Eu-GTP-γS binding studies of chimeric opioid peptide YFa.
Topics: Amino Acid Sequence; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Europium; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Space; Opioid Peptides; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Second Messenger Systems | 2011 |
Transactivation of epidermal growth factor receptor by enhanced levels of endogenous angiotensin II contributes to the overexpression of Giα proteins in vascular smooth muscle cells from SHR.
Topics: Acetylcysteine; Adenylyl Cyclases; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Colforsin; CSK Tyrosine-Protein Kinase; ErbB Receptors; Gene Expression; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypertension; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; src-Family Kinases; Transcriptional Activation | 2011 |
G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; Disease Models, Animal; Dopamine Agonists; Down Syndrome; Environment; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Isoproterenol; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Norepinephrine; Signal Transduction | 2011 |
The histamine autoreceptor is a short isoform of the H₃ receptor.
Topics: Animals; Arachidonic Acid; Autoreceptors; Brain; Calcimycin; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; Imidazoles; In Vitro Techniques; Male; Methylhistamines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Histamine H3 | 2012 |
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.
Topics: Allosteric Regulation; Animals; Arrestins; Benzoxazines; beta-Arrestins; Brain; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indoles; Kinetics; Ligands; Male; MAP Kinase Signaling System; Mice; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Receptor, Cannabinoid, CB1; Signal Transduction | 2013 |
A single-point mutation (Ala280Val) in the third intracellular loop alters the signalling properties of the human histamine H₃ receptor stably expressed in CHO-K1 cells.
Topics: Amino Acid Substitution; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetulus; Cyclic AMP; DNA, Complementary; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Point Mutation; Polymerase Chain Reaction; Radioligand Assay; Receptors, Histamine H3; Signal Transduction | 2013 |
Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Breast Neoplasms; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Isomerism; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Selective Estrogen Receptor Modulators; Tamoxifen | 2016 |