Compounds > colforsin
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colforsin and glucagon-like peptide 1

colforsin has been researched along with glucagon-like peptide 1 in 71 studies

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's25 (35.21)18.2507
2000's30 (42.25)29.6817
2010's16 (22.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fehmann, HC; Habener, JF1
Bawab, W; Chastre, E; Gespach, C1
Arnold, R; Bächle, R; Fehmann, HC; Göke, B; Göke, R; Wagner, B1
Classen, M; Fürlinger, C; Janczewska, I; Schepp, W; Schmidtler, J; Schusdziarra, V; Weigert, N1
Abrahamsen, N; Nishimura, E1
Asa, SL; Brubaker, PL; Drucker, DJ; Jin, T; Young, TA1
Göke, B; Göke, R; McGregor, GP1
Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS1
Abello, J; Bernard, C; Bosshard, A; Chayvialle, JA; Cuber, JC; Ye, F1
Classen, M; Dehne, K; Offermanns, S; Rosenthal, W; Schepp, W; Schmidtler, J1
Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G1
Bosco, D; Dériaz, N; DeVos, A; Meda, P; Pipeleers, D; Porret, A; Schuit, F; Thorens, B1
Hanafusa, T; Kuwajima, M; Matsumura, T; Matsuzawa, Y; Miki, H; Mineo, I; Miyagawa, J; Nakajima, H; Namba, M; Nishimura, T1
Laychock, SG1
Göke, B; Göke, R; Steffen, H1
Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J1
Boissard, C; Chastre, E; Marie, JC; Phan, HH; Rosselin, G1
Ding, WG; Gromada, J1
Bokvist, K; Ding, WG; Gromada, J; Holst, JJ; Nielsen, JH; Rorsman, P1
Buchan, AM; Damholt, AB; Kofod, H1
Nakata, M; Tanaka, H; Yada, T; Yaekura, K1
Abello, J; Bosshard, A; Chayvialle, JA; Chevrier, AM; Cuber, JC; Saïfia, S1
Fehmann, HC; Göke, B; Pracht, A1
Andreis, PG; Malendowicz, LK; Neri, G; Nussdorfer, GG; Tortorella, C1
Ahrén, B; Havel, PJ1
Ahrén, B; Karlsson, S; Simonsson, E1
Daniel, PB; Habener, JF; Hussain, MA1
Niki, I; Nimura, Y; Niwa, T1
Brubaker, PL; Dhanvantari, S; Izzo, A; Jansen, E1
Cerasi, E; Efendic, S; Kaiser, N; Khan, A; Nesher, R; Warwar, N1
Aizawa, T; Hashizume, K; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K1
Bhatt, HS; Easom, RA; Lawrence, MC1
Civelek, VN; Corkey, BE; Cunningham, BA; Daley, JT; Deeney, JT; Dillon, JS; Richard, AM; Tornheim, K; Yaney, GC1
Aizawa, T; Hashizume, K; Kojima, I; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K1
Drucker, DJ; Halban, PA; Hansotia, T; Li, Y; Ris, F; Yusta, B1
da Silva Xavier, G; Holz, GG; Jouaville, LS; Rutter, GA; Thomas, AP; Tsuboi, T1
Lee, JW; Romsos, DR; Swick, AG1
Bojanowska, E; Stempniak, B1
Canettieri, G; Jhala, US; Krajewski, S; Kulkarni, RN; Lin, X; Montminy, M; Reed, J; Screaton, RA; Walker, J; White, M1
Liu, C; Shen, P; Zhang, C; Zhang, CY; Zhang, J; Zhang, P; Zhang, Y1
Blume, N; Friedrichsen, BN; Gram, VK; Lee, YC; Møldrup, A; Neubauer, N; Nielsen, JH; Petersen, JS1
Matsui, H; Miura, Y1
Barbeau, A; Delghingaro-Augusto, V; Fortier, M; Guay, C; Joly, E; Lamontagne, J; Leahy, JL; Masiello, P; Mitchell, GA; Moibi, J; Nolan, CJ; Peyot, ML; Prentki, M; Przybytkowski, E; Soni, K; Wang, S1
Ball, AJ; Flatt, PR; McClenaghan, NH1
Chen, G; Deng, X; Guo, L; Hu, Y; Jiajia, J; Liu, J; Yin, F; Zhang, H; Zheng, X1
Ling, Z; Mao, R; Pipeleers, D; Van de Casteele, M; Wang, C1
Collord, GJ; Gribble, FM; Habib, AM; Reimann, F; Simpson, AK; Ward, PS; Wong, KY1
Gaisano, HY; Gao, X; Kwan, EP; Leung, YM1
Bara, H; Sambanis, A1
Belsham, DD; Dalvi, PS; Madadi, G1
Brubaker, PL; Gaisano, HY; Islam, D; Jin, T; Li, H; Wang, P; Wang, Q; Zhang, N1
McIntosh, CH; Sampaio, AV; Underhill, TM; Widenmaier, SB1
Gomez, E; Herbert, TP; Moore, CE; Xie, J1
Cnop, M; Cunha, DA; Eizirik, DL; Gurzov, EN; Igoillo-Esteve, M; Ladrière, L; Lupi, R; Marchetti, P; Ortis, F1
Bavec, A1
Harada, N; Hosaka, T; Kim Chung, le T; Nakaya, Y; Sakai, T; Sakaue, H; Yoshida, M1
Greig, NH; Holloway, HW; Li, Y; Mattson, MP; Tweedie, D1
Acitores, A; Esbrit, P; González, N; López-Herradón, A; Moreno, P; Nuche-Berenguer, B; Portal-Núñez, S; Valverde, I; Villanueva-Peñacarrillo, ML1
Abdulkader, F; Amisten, S; Bengtsson, M; Braha, O; Braun, M; De Marinis, YZ; Eliasson, L; Gribble, F; Habib, AM; Moritoh, Y; Ramracheya, R; Reimann, F; Renström, E; Rorsman, P; Rosengren, A; Salehi, A; Seino, S; Shibasaki, T; Ward, CE; Zhang, E; Zhang, Q1
Charpentier, G; Dubois, M; Jonas, JC; Kerr-Conte, J; Lang, J; Moustaïd-Moussa, N; Mulot, A; Papin, J; Pattou, F; Raoux, M; Roger, B; Vacher, P; Voy, BH1
Hedrick, JA; Juhl, K; Kang, L; Kowalski, TJ; Lan, H; Lin, HV; Wang, CF; Wright, MJ; Xu, S1
Damdindorj, B; Dezaki, K; Kakei, M; Kurashina, T; Rita, R; Sone, H; Yada, T1
Henquin, JC; Mourad, NI; Nenquin, M1
Belsham, DD; Chiang, YT; Columbus, J; Ip, W; Irwin, DM; Jin, T; Shao, W; Wang, D; Wang, Q; Wen, X; Xu, F; Zhang, H; Zhu, L1
Chernoff, J; Chiang, YT; Ip, W; Jin, T; Shao, W; Song, ZE1
Edlund, A; Eliasson, L; Esguerra, JL; Flodström-Tullberg, M; Wendt, A1
Akiyama, S; Aoki, T; Araki, O; Murakami, M; Ogiwara, T; Tsunekawa, K1
Burentogtokh, A; Ikeda, Y; Ishizawa, K; Itoh, M; Izawa-Ishizawa, Y; Kihira, Y; Tamaki, T; Tsuchiya, K1
Ali, Y; Bacaj, T; Han, W; Hong, W; Petersen, N; Rorsman, P; Südhof, TC; Wang, X; Wei, S; Wu, B1
Chimerel, C; Gribble, FM; Murison, K; Reimann, F; Riccio, C1
Fan, SH; Li, XW; Niu, Y; Shi, YW; Xiong, QF; Zhang, LH; Zhang, X1

Other Studies

71 other study(ies) available for colforsin and glucagon-like peptide 1

ArticleYear
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
    Endocrinology, 1992, Volume: 130, Issue:5

    Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella

1992
Functional and structural characterization of the secretin receptors in rat gastric glands: desensitization and glycoprotein nature.
    Bioscience reports, 1991, Volume: 11, Issue:1

    Topics: Animals; Binding Sites; Chromatography, Affinity; Colforsin; Cyclic AMP; Down-Regulation; Gastric Mucosa; Glucagon-Like Peptide 1; Male; Membrane Glycoproteins; Peptides; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Secretin; Time Factors; Vasoactive Intestinal Peptide

1991
Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas.
    Biochimica et biophysica acta, 1991, Feb-19, Volume: 1091, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide

1991
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
    The American journal of physiology, 1991, Volume: 260, Issue:6 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Inositol Phosphates; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella

1991
Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.
    Endocrinology, 1995, Volume: 136, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Ribonucleases; RNA, Messenger

1995
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
    Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Intestinal Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Electron; Neoplasm Transplantation; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

1994
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
    Life sciences, 1993, Volume: 53, Issue:17

    Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P

1993
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
    Diabetes, 1995, Volume: 44, Issue:7

    Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured

1995
Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.
    Endocrinology, 1994, Volume: 134, Issue:5

    Topics: Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Intestines; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Parasympathomimetics; Peptide Fragments; Protein Precursors; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate

1994
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 1

    Topics: Adenosine Diphosphate; Adenylyl Cyclases; Aminopyrine; Animals; Cell Membrane; Cell Separation; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; GTP-Binding Proteins; Histamine; Kinetics; Molecular Weight; Parietal Cells, Gastric; Peptide Fragments; Rats; Rats, Wistar

1994
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
    Endocrinology, 1993, Volume: 133, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured

1993
Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic beta cells.
    The Journal of biological chemistry, 1996, Apr-05, Volume: 271, Issue:14

    Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Glucagon-Like Peptide 1; Glucose Transporter Type 2; Isoquinolines; Kinetics; Methylglucosides; Molecular Sequence Data; Monosaccharide Transport Proteins; Peptides; Phosphorylation; Rats; Sulfonamides; Tumor Cells, Cultured

1996
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
    Biochimica et biophysica acta, 1996, Jun-13, Volume: 1312, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Rats

1996
Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
    Molecular and cellular endocrinology, 1995, Aug-30, Volume: 113, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Drug Tolerance; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley

1995
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured

1996
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
    Pancreas, 1996, Volume: 13, Issue:3

    Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured

1996
Effect of PACAP, VIP, glucagon, and GLP1 on cAMP production and insulin release of HIT-T15 cells is passage dependent.
    Annals of the New York Academy of Sciences, 1996, Dec-26, Volume: 805

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Line, Transformed; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine; Vasoactive Intestinal Peptide

1996
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
    Diabetes, 1997, Volume: 46, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Exocytosis; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate; Thionucleotides

1997
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.
    Diabetes, 1998, Volume: 47, Issue:1

    Topics: Adult; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Islets of Langerhans; Male; Membrane Potentials; Middle Aged; Neurotransmitter Agents; Peptide Fragments; Potassium Channels; Somatostatin

1998
Glucagon-like-peptide-1 secretion from canine L-cells is increased by glucose-dependent-insulinotropic peptide but unaffected by glucose.
    Endocrinology, 1998, Volume: 139, Issue:4

    Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dogs; Enteroendocrine Cells; Enzyme Activation; Enzyme Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Immunohistochemistry; Isoquinolines; Male; Peptide Fragments; Protein Kinase C; Protein Precursors; Somatostatin; Tetradecanoylphorbol Acetate

1998
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
    Advances in experimental medicine and biology, 1997, Volume: 426

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide

1997
Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells.
    The Journal of endocrinology, 1998, Volume: 157, Issue:1

    Topics: Animals; Bombesin; Cells, Cultured; Colforsin; Disopyramide; Dose-Response Relationship, Drug; Galanin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; GTP-Binding Proteins; Ileum; Immunohistochemistry; Male; Microscopy, Fluorescence; Peptide Fragments; Pertussis Toxin; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1998
High-level expression of the GLP-I receptor results in receptor desensitization.
    Pancreas, 1998, Volume: 17, Issue:3

    Topics: Animals; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Signal Transduction; Transfection

1998
Effects of glucagon and glucagon-like peptide-1 on glucocorticoid secretion of dispersed rat adrenocortical cells.
    Life sciences, 1999, Volume: 64, Issue:24

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Bucladesine; Colforsin; Corticosterone; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucocorticoids; In Vitro Techniques; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Steroids

1999
Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells).
    The American journal of physiology, 1999, Volume: 277, Issue:4

    Topics: Animals; Calcium; Colforsin; Cyclic AMP; Cytoplasm; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Leptin; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase C; Protein Precursors; Rats; Tumor Cells, Cultured

1999
The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation.
    Biochemical and biophysical research communications, 2000, Mar-05, Volume: 269, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Melitten; Peptide Fragments; Phospholipases A; Protein Precursors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide

2000
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.
    Diabetes, 2000, Volume: 49, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Diabetes Mellitus; DNA; DNA-Binding Proteins; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2000
Lack of effect of incretin hormones on insulin release from pancreatic islets in the bile duct-ligated rats.
    American journal of physiology. Endocrinology and metabolism, 2001, Volume: 280, Issue:1

    Topics: Animals; Bile Ducts; Bilirubin; Bucladesine; Cholestasis, Extrahepatic; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Ligation; Male; Peptide Fragments; Rats; Rats, Wistar

2001
Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.
    Endocrinology, 2001, Volume: 142, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid Endopeptidases; Cell Line; Colforsin; Gene Expression Regulation; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Kinetics; Luciferases; Mice; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Rats; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection

2001
Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.
    Diabetes, 2001, Volume: 50, Issue:2

    Topics: Animals; Colforsin; Diabetes Mellitus, Type 2; Diazoxide; Disease Models, Animal; Disease Susceptibility; Gerbillinae; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Oxidation-Reduction; Peptide Fragments; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Reference Values; Signal Transduction; Tetradecanoylphorbol Acetate

2001
Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.
    Diabetes, 2002, Volume: 51 Suppl 1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Colforsin; Cyclic AMP; Diazoxide; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Signal Transduction; Sodium Azide; Vasodilator Agents

2002
NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1.
    Diabetes, 2002, Volume: 51, Issue:3

    Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islets of Langerhans; Isoquinolines; NFATC Transcription Factors; Nuclear Proteins; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Sulfonamides; Tacrolimus; Transcription Factors; Transcription, Genetic

2002
Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.
    The Biochemical journal, 2003, Jan-01, Volume: 369, Issue:Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Lipolysis; Male; Peptide Fragments; Phosphofructokinase-2; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Wistar

2003
Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell.
    Endocrinology, 2002, Volume: 143, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Calcium; Cerulenin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Wistar

2002
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.
    The Journal of biological chemistry, 2003, Jan-03, Volume: 278, Issue:1

    Topics: Animals; Apoptosis; beta Catenin; Blood Glucose; Cell Line; Cell Survival; Colforsin; Cricetinae; Cycloheximide; Cytokines; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; In Situ Nick-End Labeling; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Peptides; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Glucagon; Signal Transduction; Streptozocin; Trans-Activators; Venoms

2003
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.
    The Biochemical journal, 2003, Jan-15, Volume: 369, Issue:Pt 2

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Carbachol; Cell Line; Chelating Agents; Cholinergic Agonists; Colforsin; Cyclic AMP; Diazoxide; Egtazic Acid; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Macrocyclic Compounds; Mitochondria; Oxazoles; Peptide Fragments; Protein Precursors; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thionucleotides

2003
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
    Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin

2003
Mechanisms involved in glucagon-like peptide-1 (7-36) amide action on the rat hypothalamo-neurohypophysial system.
    Neuroendocrinology, 2003, Volume: 77, Issue:2

    Topics: Analysis of Variance; Angiotensin II; Animals; Calcium; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Male; Neurotransmitter Agents; Organ Culture Techniques; Oxytocin; Peptide Fragments; Rats; Rats, Wistar; Second Messenger Systems; Vasopressins; Water-Electrolyte Balance

2003
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
    Genes & development, 2003, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Apoptosis; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Mice; Mice, Transgenic; Peptide Fragments; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transfection; Transgenes; Tumor Cells, Cultured

2003
Free fatty acids increase PGC-1alpha expression in isolated rat islets.
    FEBS letters, 2005, Feb-28, Volume: 579, Issue:6

    Topics: Animals; Cells, Cultured; Colforsin; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Liver; Male; Mice; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Transcription Factors

2005
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
    The Journal of endocrinology, 2006, Volume: 188, Issue:3

    Topics: Adenylyl Cyclases; Androstadienes; Animals; Animals, Newborn; Cell Line; Cell Proliferation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Enzyme Activation; Flavonoids; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Human Growth Hormone; Imidazoles; Insulin-Secreting Cells; Isoquinolines; Liraglutide; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Stimulation, Chemical; Sulfonamides; Transcription, Genetic; Transduction, Genetic; Wortmannin

2006
Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic beta-cells.
    Toxicology and applied pharmacology, 2006, Nov-01, Volume: 216, Issue:3

    Topics: Animals; Bucladesine; Calcium; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Environmental Pollutants; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Mesocricetus; Organotin Compounds; Sodium

2006
Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.
    Diabetologia, 2006, Volume: 49, Issue:9

    Topics: Animals; Binding Sites; Colforsin; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Lactones; Lipase; Lipid Metabolism; Lipolysis; Models, Biological; Orlistat; Oxidation-Reduction; Rats; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

2006
Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide.
    The Journal of endocrinology, 2006, Volume: 190, Issue:3

    Topics: Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclohexanes; Dose-Response Relationship, Drug; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Nateglinide; Phenylalanine; Potassium Channels; Protein Kinase C; Stimulation, Chemical; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate

2006
Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2006, Volume: 24, Issue:7

    Topics: Animals; Blotting, Western; Butadienes; Cell Differentiation; Cell Line; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GAP-43 Protein; Gene Expression; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Iridoids; Luciferases; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Neurons; Neuroprotective Agents; Nitriles; PC12 Cells; Pyrans; Rats; Receptors, Glucagon; Transfection

2006
Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:4

    Topics: Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activation; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Glutamate Decarboxylase; Insulin-Secreting Cells; Isoenzymes; Male; Rats; Rats, Wistar

2007
Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line.
    Diabetologia, 2007, Volume: 50, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Colforsin; Cyclic AMP; Enteroendocrine Cells; Glucagon-Like Peptide 1; Humans; Ion Channels; Membrane Potentials

2007
Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.
    Pancreas, 2007, Volume: 35, Issue:3

    Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon-Like Peptide 1; Guanine Nucleotide Exchange Factors; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Membrane Fusion; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Secretory Vesicles; Sulfonamides

2007
Insulin-secreting L-cells for the treatment of insulin-dependent diabetes.
    Biochemical and biophysical research communications, 2008, Jun-20, Volume: 371, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Diabetes Mellitus; Drug Resistance; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Neomycin; Proinsulin; Transfection

2008
Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1.
    Biochemical and biophysical research communications, 2008, Nov-28, Volume: 376, Issue:4

    Topics: Animals; Cell Line; Colforsin; Exenatide; Gene Expression; Glucagon-Like Peptide 1; Glucose; Humans; Hypothalamus; Insulin; Insulin-Secreting Cells; Mice; Neurons; Peptides; Promoter Regions, Genetic; Rats; RNA, Messenger; Venoms

2008
Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:1

    Topics: Blotting, Northern; Blotting, Western; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enteroendocrine Cells; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Guanine Nucleotide Exchange Factors; Humans; Immunohistochemistry; Proglucagon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transfection

2009
Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide.
    The Journal of biological chemistry, 2009, Apr-17, Volume: 284, Issue:16

    Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Enzyme Activation; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Insulin-Secreting Cells; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats

2009
Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells.
    Journal of molecular biology, 2009, Jun-12, Volume: 389, Issue:3

    Topics: Animals; Cell Line, Tumor; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Ribosomal Protein S6 Kinases; Serine

2009
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
    Diabetes, 2009, Volume: 58, Issue:12

    Topics: Animals; Antigens, Differentiation; Apoptosis; Blotting, Western; Cell Survival; Colforsin; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Endoplasmic Reticulum; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Heat-Shock Proteins; Hypoglycemic Agents; Insulin-Secreting Cells; Lipid Metabolism; Male; Peptides; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Receptors, Glucagon; Regulatory Factor X Transcription Factors; RNA Interference; Transcription Factors; Up-Regulation; Venoms

2009
Constructing glucagon like peptide-1 receptor fused with derivatives of GFP for visualizing protein-protein interaction in living cells.
    Molecular biology reports, 2010, Volume: 37, Issue:6

    Topics: Animals; Cell Survival; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Green Fluorescent Proteins; Humans; Protein Interaction Mapping; Protein Transport; Receptors, Glucagon; Recombinant Fusion Proteins

2010
Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression.
    Biochemical and biophysical research communications, 2009, Dec-18, Volume: 390, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipokines; Adiponectin; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Inflammation; Insulin Resistance; Isoquinolines; Mice; Peptides; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Receptors, Glucagon; RNA, Messenger; Sulfonamides; Venoms

2009
Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells.
    Journal of neurochemistry, 2010, Volume: 113, Issue:6

    Topics: Activating Transcription Factor 4; Adrenergic Agents; Apoptosis; bcl-2-Associated X Protein; Bromodeoxyuridine; Butadienes; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hydrogen Peroxide; Hypoglycemic Agents; Neuroblastoma; Neuroprotective Agents; Nitriles; Oxidants; Oxidopamine; Peptides; Proto-Oncogene Proteins c-bcl-2; Receptors, Glucagon; Signal Transduction; Time Factors; Transfection; Venoms

2010
Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor.
    Journal of cellular physiology, 2010, Volume: 225, Issue:2

    Topics: 3T3 Cells; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Exenatide; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Humans; Mice; Osteoblasts; Parathyroid Hormone; Peptides; Protein Binding; Rats; Receptors, Glucagon; Venoms

2010
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
    Cell metabolism, 2010, Jun-09, Volume: 11, Issue:6

    Topics: Animals; Calcium Channels, L-Type; Calcium Channels, N-Type; Carrier Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epinephrine; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Guanine Nucleotide Exchange Factors; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred C57BL

2010
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
    Diabetologia, 2011, Volume: 54, Issue:2

    Topics: Adenylyl Cyclases; Animals; Calcium; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Cytophotometry; Electrophysiology; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin-Secreting Cells; Models, Biological; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Receptors, Glucagon

2011
Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: Animals; Calcium; Cell Line; Colforsin; Colon; Endocannabinoids; Enteroendocrine Cells; Glucagon-Like Peptide 1; Glucose; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Oleic Acids; Receptors, G-Protein-Coupled

2012
Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells.
    FEBS letters, 2012, Jul-30, Volume: 586, Issue:16

    Topics: Adenylyl Cyclases; Animals; Calcium; Colforsin; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Ghrelin; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Models, Biological; Rats; Rats, Wistar; Time Factors

2012
cAMP-mediated and metabolic amplification of insulin secretion are distinct pathways sharing independence of β-cell microfilaments.
    Endocrinology, 2012, Volume: 153, Issue:10

    Topics: Actin Cytoskeleton; Actins; Animals; Colforsin; Cyclic AMP; Exocytosis; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Peptide Fragments; Signal Transduction

2012
The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis.
    Diabetes, 2013, Volume: 62, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Brain; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Tract; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucose; Homeostasis; Hypothalamus; Male; Mice; Mice, Transgenic; Organ Specificity; Phosphorylation; Proglucagon; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Transcription Factor 7-Like 2 Protein; Wnt Signaling Pathway

2013
Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.
    Endocrinology, 2014, Volume: 155, Issue:6

    Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Glucagon-Like Peptide 1; Glucose; Hepatocytes; Liver; Male; Mice; Mice, Knockout; p21-Activated Kinases; Pyrazines; Real-Time Polymerase Chain Reaction; Signal Transduction; Sitagliptin Phosphate; Triazoles

2014
CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
    BMC medicine, 2014, May-28, Volume: 12

    Topics: Animals; Anoctamin-1; Calcium; Calcium Channels; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Exocytosis; Glucagon-Like Peptide 1; Glycine; Humans; Hydrazines; Insulin-Secreting Cells; Insulins; Ion Channels; Mice; Neoplasm Proteins; Patch-Clamp Techniques

2014
Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line.
    Life sciences, 2014, Oct-12, Volume: 115, Issue:1-2

    Topics: Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exenatide; Gene Expression Regulation, Neoplastic; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Insulinoma; Iodide Peroxidase; Mice; Pancreatic Neoplasms; Peptides; RNA, Messenger; Signal Transduction; Triiodothyronine; Triiodothyronine, Reverse; Venoms

2014
Hypoxia decreases glucagon-like peptide-1 secretion from the GLUTag cell line.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:4

    Topics: Adenosine Triphosphate; Animals; Cell Line; Colforsin; Colon; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Eating; Glucagon-Like Peptide 1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Isoquinolines; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Proglucagon; Proprotein Convertase 1; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides

2015
Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-11, Volume: 112, Issue:32

    Topics: Amino Acid Sequence; Animals; Colforsin; Conserved Sequence; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Evolution, Molecular; Exenatide; Exocytosis; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; HEK293 Cells; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice, Knockout; Molecular Sequence Data; Mutation; Peptides; Phosphorylation; Phosphoserine; Rats; Receptors, Glucagon; Synaptotagmins; Venoms

2015
Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.
    Endocrinology, 2017, 10-01, Volume: 158, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Colforsin; Enteroendocrine Cells; Glucagon-Like Peptide 1; Membrane Potentials; Mice; Nifedipine; omega-Conotoxin GVIA; Optogenetics; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rhodopsin; Sodium Channel Blockers; Tetrodotoxin; Vasodilator Agents

2017
GLP-1 attenuates Ang II-induced proliferation and migration in rat aorta smooth muscle cells
    Die Pharmazie, 2018, 12-01, Volume: 73, Issue:12

    Topics: Amides; Angiotensin II; Animals; Aorta; Cell Movement; Cell Proliferation; Cells, Cultured; Colforsin; Glucagon-Like Peptide 1; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2018