colforsin has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.57) | 18.7374 |
| 1990's | 29 (51.79) | 18.2507 |
| 2000's | 21 (37.50) | 29.6817 |
| 2010's | 4 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Childers, SR; Fleming, L; Konkoy, C; Marckel, D; Pacheco, M; Sexton, T; Ward, S | 1 |
| Childers, SR; Nijssen, PC; Sexton, T | 1 |
| Rengel, I; Schulz, R; Sinowatz, F | 1 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Gnegy, ME; Mangels, LA | 1 |
| Bleasdale, JE; Denlinger, LC; Fisher, SK; Mostafapour, SP; Thompson, AK | 1 |
| Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
| Johnson, SM; Pillai, NP | 1 |
| Eriksson, PS; Hansson, E; Rönnbäck, L | 1 |
| Cox, BM; Puttfarcken, PS | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Childers, SR; Dworkin, SI; Kluttz, BW; Vrana, KE | 1 |
| Ingram, SL; Williams, JT | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Chakrabarti, S; Law, PY; Loh, HH | 1 |
| Jauzac, P; Polastron, J | 1 |
| Bare, LA; Mansson, E; Yang, D | 1 |
| Côté, TE; Izenwasser, S; Weems, HB | 1 |
| Dorow, J; Feller, DJ; Stuart, JF | 1 |
| Avidor-Reiss, T; Bayewitch, M; Levy, R; Matus-Leibovitch, N; Nevo, I; Vogel, Z | 1 |
| Hirst, RA; Lambert, DG | 1 |
| George, SR; Kouvelas, A; O'Dowd, BF; Pak, Y; Rasmussen, J; Scheideler, MA | 1 |
| Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
| Höllt, V; Koch, T; Kroslak, T; Mayer, P; Raulf, E | 1 |
| Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
| Fukuda, K; Kato, S; Mima, H; Mori, K; Morikawa, H; Shoda, T | 2 |
| Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
| Cassel, JA; Daubert, JD; DeHaven, RN; Gong, J; Mansson, E; Strong, JA; Yu, G; Yu, L; Yue, X; Zhang, S | 1 |
| Wang, HL | 1 |
| Andria, ML; Hiller, JM; Onoprishvili, I; Simon, EJ; Vilim, FS | 1 |
| Aghajanian, GK; Jolas, T; Nestler, EJ | 1 |
| Deng, HB; George, SR; O'Dowd, BF; Pak, Y; Surratt, CK; Uhl, GR; Wang, JB; Yu, Y | 1 |
| Allen, CN; Grandy, DK; Ikeda, M; Nelson, CS; Shinagawa, H; Shinoe, T; Sugiyama, T; Yoshioka, T | 1 |
| Baldelli, P; Carabelli, V; Carbone, E; Hernández-Guijo, JM | 1 |
| Bot, G; Chesselet, MF; Mehta, A; Reisine, T | 1 |
| Brusciano, D; Vincent, P | 1 |
| Aghajanian, GK; Akbarian, S; Bates, B; Bothwell, M; Coppola, V; Fan, G; Jaenisch, R; Kosofsky, BE; Kucera, J; Liu, RJ; Nestler, EJ; Pejchal, T; Skirboll, SL; Sun, LD; Taylor, JR; Tessarollo, L; Wilson, MA | 1 |
| Akaike, N; Cho, YW; Han, SH; Min, BI; Rhee, JS | 1 |
| Lu, YF; Rothman, RB; Xu, H | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Brillet, K; Bucher, B; Lecat, S; Pattus, F; Perret, BG; Rabut, G; Wagner, R | 1 |
| Boda, K; Gintzler, AR; Szücs, M | 1 |
| Rothman, RB; Wang, J; Wang, X; Xu, H | 1 |
| Cho, YW; Hahm, ET; Lee, JJ; Min, BI | 1 |
| Ming, Y; Persson, AI; Terenius, L; Zarnegar, P | 1 |
| Bohn, LM; Partilla, JS; Prisinzano, TE; Rothman, RB; Rutherford, JM; Tidgewell, K; Wang, X; Xu, H | 1 |
| Clark, MJ; Traynor, JR | 1 |
| Gianotti, RJ; Ho, A; Kreek, MJ; Kroslak, T; Laforge, KS; Nielsen, DA | 1 |
| Clark, MJ; Linderman, JJ; Traynor, JR | 1 |
| Liu-Chen, LY; Traynor, JR; Wang, Q | 1 |
| Alonso-Vanegas, M; Benyhe, S; Borsodi, A; Gaona, A; Orozco-Suarez, S; Páldy, E; Rocha, L; Villeda-Hernandez, J | 1 |
| Clark, MJ; Neubig, RR; Roman, DL; Roof, RA; Talbot, JN; Tesmer, JJ; Traynor, JR | 1 |
| Adan, RA; Meye, FJ; Ramakers, GM; Smidt, MP; van Zessen, R | 1 |
| Traynor, JR; Wang, Q | 1 |
| Abogadie, F; Connor, M; Knapman, A; McIntrye, P | 1 |
56 other study(ies) available for colforsin and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Imidodiphosphate; Analgesics; Animals; Brain; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Neurons; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; RNA, Messenger | 1992 |
Opioid-inhibited adenylyl cyclase in rat brain membranes: lack of correlation with high-affinity opioid receptor binding sites.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding Sites; Brain; Cell Membrane; Colforsin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine Triphosphate; Male; Naloxone; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sodium; Sodium Chloride; Sodium Fluoride | 1992 |
Opioid-controlled adenylate cyclase in the guinea-pig myenteric plexus is confined to nerve somata.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Receptors, Opioid, mu | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Analgesics; Brimonidine Tartrate; Bucladesine; Calcium; Calmodulin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Cytosol; Edetic Acid; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Quinoxalines; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.
Topics: Alprostadil; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrenes; GTP-Binding Proteins; Humans; Inositol; Kinetics; Neuroblastoma; Oxotremorine; Phosphatidylinositols; Pyrrolidinones; Receptors, Muscarinic; Scopolamine; Type C Phospholipases | 1991 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
Hyperpolarization of myenteric neurons by opioids does not involve cyclic adenosine-3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Neurons | 1990 |
Opiate receptors in neuronal primary cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fetus; Morphine; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Morphine-induced desensitization and down-regulation at mu-receptors in 7315C pituitary tumor cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Morphine; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1989 |
Sodium dependent 3H-noradrenaline release from rat neocortical slices in the absence of extracellular calcium: presynaptic modulation by mu-opioid receptor and adenylate cyclase activation.
Topics: Adenylyl Cyclases; Animals; Calcium; Cerebral Cortex; Colforsin; Desipramine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Extracellular Space; Male; Norepinephrine; Ouabain; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium; Veratrine | 1988 |
Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain.
Topics: Analgesics; Animals; Colforsin; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Male; Models, Molecular; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Opioid inhibition of Ih via adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cations; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Electric Conductivity; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ion Channels; Neurons; Nodose Ganglion | 1994 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine.
Topics: Analgesics; Animals; Binding, Competitive; Cell Line; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mice; Models, Biological; Morphine; Neuroblastoma; Receptors, Opioid, mu; Time Factors | 1995 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; CHO Cells; Colforsin; Cricetinae; Diprenorphine; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Genetic Variation; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Receptors, Opioid, mu; RNA, Messenger; Transfection | 1994 |
Naltrexone-induced upregulation of mu opioid receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Membrane; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Naltrexone; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 1993 |
Mu-opiate receptor binding and function in HOT and COLD selected lines of mice.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Body Temperature; Brain; Brain Chemistry; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethanol; Female; Levorphanol; Male; Mice; Mice, Inbred Strains; Naloxone; Nerve Tissue Proteins; Receptors, Opioid, mu | 1993 |
Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Naloxone; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1995 |
Do SH-SY5Y human neuroblastoma cells express cannabinoid receptors?
Topics: Adenylyl Cyclase Inhibitors; Cannabinoids; Colforsin; Cyclic AMP; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Potassium; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Tumor Cells, Cultured | 1995 |
Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.
Topics: Analgesics; Animals; Binding Sites; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Kidney; Kinetics; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sensitivity and Specificity; Stimulation, Chemical; Transfection | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Site mutation in the rat mu-opioid receptor demonstrates the involvement of calcium/calmodulin-dependent protein kinase II in agonist-mediated desensitization.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Mutagenesis, Site-Directed; Mutation; Oocytes; Rats; Receptors, Opioid, mu; Xenopus laevis | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Adaptations to chronic agonist exposure of mu-opioid receptor-expressing Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Receptors, Opioid, mu | 1998 |
Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Naloxone; Receptors, Cell Surface; Receptors, Opioid; Transfection | 1998 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
Endomorphins fully activate a cloned human mu opioid receptor.
Topics: Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Humans; Oligopeptides; Oocytes; Potassium Channels; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Xenopus | 1998 |
A conserved arginine in the distal third intracellular loop of the mu-opioid receptor is required for G protein activation.
Topics: Adenylyl Cyclases; Animals; Arginine; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Humans; Kidney; Ligands; Mutation; Radioligand Assay; Rats; Receptors, Opioid, mu | 1999 |
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics, Opioid; Animals; Base Sequence; Benzeneacetamides; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Corpus Striatum; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Pyrrolidines; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 1999 |
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cardiovascular Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Isoquinolines; Male; Membrane Potentials; Morphine; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Phenylephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Sulfonamides; Sympathomimetics; Tetrazoles; Tetrodotoxin; Thionucleotides | 2000 |
Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; CHO Cells; Colforsin; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Molecular Sequence Data; Mutation; Phosphorylation; Protein Binding; Receptors, Opioid, mu; Transfection | 2000 |
Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Bromo Cyclic Adenosine Monophosphate; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Bucladesine; Calcium; Calcium Signaling; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Gene Expression; Inositol 1,4,5-Trisphosphate; Peptides; Pyrrolidines; Rats; Receptors, Opioid, kappa; Thionucleotides; Transfection | 2001 |
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Autocrine Communication; Calcium; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; GABA Antagonists; Isoquinolines; Kinetics; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Kinase Inhibitors; Sulfonamides; Suramin | 2001 |
Endomorphin-1: induction of motor behavior and lack of receptor desensitization.
Topics: Animals; Behavior, Animal; Catalepsy; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Administration Routes; Dyskinesia, Drug-Induced; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Globus Pallidus; Humans; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Oligopeptides; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Transfection | 2001 |
Cyclic AMP imaging in neurones in brain slice preparations.
Topics: Animals; Brain; Cell Nucleus; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dendrites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescein; Fluorescent Dyes; GTP-Binding Proteins; Membrane Potentials; Microelectrodes; Microscopy, Fluorescence; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Radiometry; Receptors, Cell Surface; Rhodamines | 2001 |
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Topics: Aging; Animals; Avoidance Learning; Brain; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Intermediate Filament Proteins; Locus Coeruleus; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Morphine Dependence; Nerve Tissue Proteins; Nestin; Neurons; Neurotrophin 3; Signal Transduction; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 2001 |
Antagonizing effect of protein kinase C activation on the mu-opioid agonist-induced inhibition of high voltage-activated calcium current in rat periaqueductal gray neuron.
Topics: Analgesics, Opioid; Animals; Calcium Channels; Calcium Signaling; Carcinogens; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Female; Male; Membrane Potentials; Neurons; Pain; Periaqueductal Gray; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Staurosporine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2001 |
Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu opioid receptor.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Culture Techniques; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activators; Heterotrimeric GTP-Binding Proteins; Morphine; Narcotics; Receptors, Opioid, mu; Sulfur Radioisotopes | 2003 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics | 2003 |
Dual effects of DAMGO [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on adenylyl cyclase activity: implications for mu-opioid receptor Gs coupling.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Colforsin; Cricetinae; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; GTP-Binding Protein alpha Subunits, Gs; Narcotics; Peptide Fragments; Peptides; Pertussis Toxin; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 2004 |
Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Cloning, Molecular; Colforsin; Cyclic AMP; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Morphine; Neuroblastoma; Oligonucleotides, Antisense; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2004 |
Activation of protein kinase C antagonizes the opioid inhibition of calcium current in rat spinal dorsal horn neurons.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Colforsin; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Isoquinolines; Male; Maleimides; Membrane Potentials; Narcotics; Patch-Clamp Techniques; Posterior Horn Cells; Potassium Channel Blockers; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetrodotoxin | 2004 |
Opioid-induced regulation of gene expression in PC12 cells stably transfected with mu-opioid receptor.
Topics: Analgesics, Opioid; Animals; Annexin A5; Blotting, Western; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation; Humans; Immunohistochemistry; Naloxone; Narcotic Antagonists; Narcotics; Oligonucleotide Array Sequence Analysis; PC12 Cells; Protein Binding; Radioligand Assay; Rats; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2006 |
A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Drug Tolerance; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Furans; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Narcotic Antagonists; Opioid-Related Disorders; Pyrones; Radioligand Assay; Receptors, Opioid, mu | 2007 |
Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics, Opioid; Blotting, Western; Cell Line; Colforsin; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mutation; Pertussis Toxin; Phosphodiesterase Inhibitors; Receptors, Opioid, mu; Time Factors; Transfection | 2006 |
The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Cell Membrane; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fibroblasts; Gene Transfer Techniques; Humans; Kidney; Mesocricetus; Polymorphism, Single Nucleotide; Receptors, Opioid, mu | 2007 |
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model.
Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Models, Biological; Mutant Proteins; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; RGS Proteins; Signal Transduction; Sulfur Radioisotopes | 2008 |
Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.
Topics: Analgesics, Opioid; Animals; Benzamides; Cell Line, Tumor; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glioma; Glycosylation; Humans; Kidney; Mice; Mitogen-Activated Protein Kinases; Morphine; Neuroblastoma; Piperazines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; RGS Proteins; RNA Interference; Signal Transduction; Transfection | 2009 |
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Topics: Adenylyl Cyclases; Adult; Central Nervous System Agents; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Epilepsy, Temporal Lobe; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Neocortex; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Sulfur Radioisotopes; Temporal Lobe; Tritium; Young Adult | 2009 |
Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Digitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Protein Binding; Rats; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2010 |
Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dopaminergic Neurons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activators; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Morphine; Pregnancy; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2012 |
Modulation of μ-opioid receptor signaling by RGS19 in SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Animals; Benzamides; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; HEK293 Cells; Humans; Mitogen-Activated Protein Kinases; Morphine; Nociceptin; Nociceptin Receptor; Opioid Peptides; PC12 Cells; Piperazines; Protein Kinase C; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; RGS Proteins; Signal Transduction | 2013 |
A real-time, fluorescence-based assay for measuring μ-opioid receptor modulation of adenylyl cyclase activity in Chinese hamster ovary cells.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence; Humans; Pertussis Toxin; Receptors, Opioid, mu; Signal Transduction | 2014 |