coformycin has been researched along with adenosine in 125 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 108 (86.40) | 18.7374 |
| 1990's | 9 (7.20) | 18.2507 |
| 2000's | 6 (4.80) | 29.6817 |
| 2010's | 2 (1.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Antonini, I; Cristalli, G; Franchetti, P; Grifantini, M; Lupidi, G; Martelli, S; Riva, F | 1 |
| Cheviet, T; Lefebvre-Tournier, I; Peyrottes, S; Wein, S | 1 |
| Kiffe, H; Puchstein, C; Schwabe, U; Trost, T | 1 |
| Muller, MJ; Paton, DM | 1 |
| Arendes, J; Maidhof, A; Müller, WE; Umezawa, H; Zahn, RK | 1 |
| Glazer, RI; Legraverend, M | 1 |
| Glazer, RI; Peale, AL | 2 |
| Johnson, RM; Lightbody, JJ; Uberti, J | 1 |
| Lum, CT; Marz, R; Plagemann, PG; Wohlhueter, RM | 1 |
| Cristalli, G; Falasca, M; Lupidi, G; Marmocchi, F; Riva, F; Venardi, G | 1 |
| Cunha, RA; Sebastião, AM | 1 |
| Bass, BL; Crain, PF; McCloskey, JA; Polson, AG; Pomerantz, SC | 1 |
| Begleiter, A; Cavers, DJ; Israels, LG; Johnston, JB; Leith, MK; Pugh, L; Wilkins, JA | 1 |
| Bakkeren, JA; De Abreu, RA; van Baal, JM; van der Kraan, PM; van Zandvoort, PM | 1 |
| Columbo, M; Kagey-Sobotka, A; Lichtenstein, LM; Marone, G; Peachell, PT | 1 |
| Lichtenstein, LM; Peachell, PT; Schleimer, RP | 1 |
| Altschuld, RA; Brierley, GP; Hohl, CM; Wimsatt, DK | 1 |
| Blanc, CM; Cataldo, F; Derossi, G; Ho, AD; Kuse, R; Lauria, F; McVie, G; Stryckmans, P; Thaler, J; Willemze, R | 1 |
| Ogasawara, N; Roth, E; Schulman, S | 1 |
| Baker, DC; Hebbler, AK; Pornbanlualap, S; Suhadolnik, RJ; Tiwari, KN | 1 |
| Hostetter, MK; Johnson, GM | 1 |
| Bontemps, F; Van den Berghe, G | 1 |
| Marquardt, DL; Walker, LL | 1 |
| Fraser, LR; Monks, NJ | 1 |
| Allan, PW; Bennett, LL; Brockman, RW; Clayton, JD; Rose, LM; Shaddix, SC; Shealy, YF | 1 |
| Belt, JA; Jarvis, SM; Paterson, AR; Wu, JS; Young, JD | 1 |
| de Bruijn, CH; Dinjens, WN; Roos, D; van Doorn, R; van Laarhoven, JP; Zeijlemaker, WP | 1 |
| Fabian, I; Williams, Z | 1 |
| Hammerschmidt, DE; Skubitz, KM; Wickham, NW | 1 |
| O'Regan, MH; Phillis, JW; Walter, GA | 1 |
| Klenow, H; Ostergaard, E | 1 |
| Burnstock, G; Centelles, JJ; Franco, R; Hoyle, CH | 1 |
| Ballerini, P; Caciagli, F; Ciccarelli, R; Di Iorio, P; Tacconelli, L | 1 |
| Decking, UK; Juengling, E; Kammermeier, H | 1 |
| Das, DK; Steinberg, H | 1 |
| Buc, HA; Garreau, F; Hamet, M; Moncion, A; Pérignon, JL; Thuillier, L | 1 |
| Ingolia, DE; Kaufman, RJ; Kellems, RE; Murtha, P; Yeung, CY | 1 |
| Holland, MJ | 1 |
| Chen, SF; Cleaveland, JS; Hollmann, AB; Parks, RE; Stoeckler, JD; Wiemann, MC | 1 |
| Plagemann, PG | 1 |
| Boston, G; Paton, DM; Webster, DR | 1 |
| Bakkeren, JA; De Abreu, RA; de Bruijn, CH; van der Krann, PM; van Laarhoven, JP; van Zandvoort, PM | 1 |
| Carson, DA; Kajander, EO; Kubota, M; Willis, EH | 1 |
| Bontemps, F; Hers, HG; Van den Berghe, G | 1 |
| Heike, T; Katamura, K; Kubota, M; Mikawa, H; Shinomiya, K | 1 |
| DeLong, RE; Phillis, JW | 1 |
| Kontinen, VP; Pispa, JP | 1 |
| Baker, DC; Dechter, JJ; Hanvey, JC; Hawkins, ES; Suhadolnik, RJ; Tunac, JB | 1 |
| Dmitrenko, NP; Goroshnikova, TV | 1 |
| Kraupp, M; Plagemann, PG; Wohlhueter, RM | 2 |
| Hubbell, HR; Lee, C; Pequignot, EC; Suhadolnik, RJ; Willis, DH | 1 |
| Plagemann, PG; Wohlhueter, RM | 3 |
| Cohen, MB; Glazer, RI | 1 |
| Wolberg, G; Zimmerman, TP | 1 |
| Archer, S; Chan, VL; Ho, JH; Juranka, PF | 1 |
| Frayne, EG; Harrison, ML; Ingolia, DE; Kellems, RE; Orengo, IF; Rudolph, FB; Yeung, CY | 1 |
| Akuzawa, Y; Kurashige, S; Mitsuhashi, S | 1 |
| Saito, T; Yamaguchi, J | 1 |
| Bugg, CE; Einsphar, HM; Montgomery, JA; Thomas, HJ; Zell, AL | 1 |
| Calabresi, P; Crabtree, GW; Cummings, FJ; Jordan, M; LaBresh, K; Spremulli, EN | 1 |
| Buttin, G; Debatisse, M; Fernandez-Mejia, C | 1 |
| Azuma, H; Ishikawa, M; Takashima, Y; Yamakado, T | 1 |
| Conti, M; Monaco, L; Toscano, MV | 1 |
| Bagnara, AS; Kyd, JM | 1 |
| Creveling, CR; Daly, JW; McNeal, ET | 1 |
| Daly, JW; Nimit, Y; Skolnick, P | 1 |
| Agarwal, RP; Kufe, DW; Major, PP | 3 |
| Holmquist, CA; Newby, AC | 1 |
| Behrman, HR; Brennan, TJ; Gore, SD; Ohkawa, R | 1 |
| Chagoya de Sanchez, V; Souness, JE; Stouffer, JE | 1 |
| Cronstein, BN; Hirschhorn, R; Kramer, SB; Weissmann, G | 1 |
| Glazer, RI; Knode, MC | 1 |
| Daddona, PE; Kelley, WN; Lambros, C; Webster, HK; Wiesmann, WP | 1 |
| Barankiewicz, J; Cohen, A | 1 |
| Hudig, D; Redelman, D | 1 |
| Carson, DA; Iizasa, T; Kubota, M | 1 |
| Cseppentö, A; Németh, M; Papp, JG; Szegi, J; Szekeres, L; Szentmiklósi, AJ | 2 |
| Bergeron, M; Hoang, T | 1 |
| Falletta, JM; Hershfield, MS; Kinney, TR; Koller, CA; Kredich, NM; Kurtzberg, J; Mitchell, BS | 1 |
| Helland, S; Ueland, PM | 1 |
| Holmquist, CA; Illingworth, J; Newby, AC; Pearson, JD | 1 |
| Chang, Y; Hacker, B | 2 |
| Broch, OJ; Helland, S; Ueland, PM | 1 |
| Djuricic-Nedelson, M; Green, RD; Radulovacki, M; Virus, RM | 1 |
| Baker, DC; Hanvey, JC; Hardman, JK; Suhadolnik, RJ | 1 |
| Ametani, MS; Belzer, FO; Lutz, MF; Southard, JH | 1 |
| Baer, HP; Vriend, R | 1 |
| Heyn, R; Koller, CA; Mitchell, BS | 1 |
| Balis, ME; Good, RA; Ikehara, S; Pahwa, R; Tedde, A; Trotta, PP | 1 |
| Hayward, AR | 1 |
| Coleman, MS; Hutton, JJ; Koller, CA; Mitchell, BS; Siaw, MF | 1 |
| Koller, CA; Mitchell, BS; Nichamin, LD; Stetson, PL | 1 |
| Cybulski, RL; Fry, DW; Goldman, ID | 1 |
| Blatt, J; Glazer, RI; Holcenberg, JS; Lipton, J; Murphy, SB; Poplack, DG; Rivera, G; Sallan, S; Venner, PM | 1 |
| Cartier, PH; Garreau, F; Thuillier, L | 1 |
| Cass, CE; Muhs, WH; Robins, MJ; Selner, M; Tan, TH | 1 |
| Hirschhorn, R; Kuritsky, L; Ratech, H; Thorbecke, GJ | 1 |
| Kuttesch, JF; Nelson, JA | 1 |
| Calabresi, P; Chu, SH; Crabtree, GW; Dexter, DL; Diamond, I; Farineau, DM; Ghoda, LY; McGowan, DL; Parks, RE; Spremulli, EN | 1 |
| Helmsworth, M; Ritch, PS | 1 |
| Belch, A; Brox, LW; Pollock, E | 1 |
| Kotb, M; Veit, BC | 1 |
| Braun, J; Rosen, FS; Unanue, ER | 1 |
| Hirschhorn, R; Kuritsky, L; Roegner-Maniscalco, V; Rosen, FS | 1 |
| Kamiya, T; Tanaka, Y; Tsuyuki, M; Yoshihara, K | 1 |
| Blay, J; Hoskin, DW; White, TD | 1 |
| Britt, BM; Castro, C | 1 |
| Dale, N | 1 |
| Browning, MJ; Hohl, CM; Jurkowitz, MS; Litsky, ML | 1 |
| Dancer, JE; Dudfield, PJ; Earnshaw, CG; Hewitt, BD; Lindell, SD; Moloney, BA | 1 |
| Barry, CP; Lind, SE | 1 |
| Dale, N; Frenguelli, BG; Pearson, T | 1 |
| Fujimori, H; Pan-Hou, H; Yasuda, M | 1 |
| Knowles, AF; Wen, LT | 1 |
| Eguchi, N; Hayaishi, O; Huang, ZL; Mochizuki, T; Okada, T; Sugita, Y; Urade, Y | 1 |
| Fredholm, BB; Hayaishi, O; Huang, ZL; Oishi, Y; Urade, Y | 1 |
| Cai, YS; Chen, W; Deng, Z; Gao, Y; Gong, R; Hong, K; Hu, Y; Jiang, M; Kong, L; Liu, P; Price, NPJ; Xu, G; Xu, L | 1 |
1 review(s) available for coformycin and adenosine
| Article | Year |
|---|---|
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Topics: Antimalarials; Biological Transport; Drug Design; Erythrocytes; Humans; Inhibitory Concentration 50; Malaria; Nucleosides; Nucleotides; Plasmodium falciparum; Purines; Pyrimidines | 2019 |
1 trial(s) available for coformycin and adenosine
| Article | Year |
|---|---|
Pentostatin (2'deoxycoformycin) for the treatment of lymphoid neoplasms.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Antineoplastic Agents; Coformycin; DNA, Neoplasm; Drug Evaluation; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Prolymphocytic; Multicenter Studies as Topic; Neoplasm Proteins; Pentostatin; Ribonucleosides; Sezary Syndrome | 1989 |
123 other study(ies) available for coformycin and adenosine
| Article | Year |
|---|---|
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cattle; Intestines; Nucleoside Deaminases | 1984 |
Specific binding of 3H-adenosine to rat brain membranes.
Topics: Adenosine; Animals; Binding Sites; Brain; Coformycin; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Membranes; Protein Binding; Rats; Temperature | 1979 |
Presynaptic inhibitory actions of 2-substituted adenosine derivatives on neurotransmission in rat vas deferens: effects of inhibitors of adenosine uptake and deamination.
Topics: Adenosine; Animals; Atropine; Coformycin; Deamination; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenoxybenzamine; Rats; Synaptic Transmission; Theophylline; Vas Deferens | 1979 |
Influence of coformycin on the cytostatic activity of 9-beta-D-arabinofuranosyladenine and adenosine in mouse L5178y cells.
Topics: Adenosine; Cell Division; Cell Line; Coformycin; Deoxyadenosines; Kinetics; Ribonucleosides; Vidarabine | 1978 |
Inhibition of the phosphorylation of nonhistone chromosomal proteins by cordycepin and xylosyladenine in L1210 cells in vitro.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Chromosomal Proteins, Non-Histone; Coformycin; Deoxyadenosines; In Vitro Techniques; Isoelectric Focusing; Leukemia L1210; Mice; Neoplasm Proteins; Phosphorylation; RNA, Neoplasm; Xylose | 1978 |
Evidence that xylosyladenine affects methylation by inhibition of S-adenosyl-L-methionine synthesis.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Nucleus; Coformycin; Deoxyadenosines; In Vitro Techniques; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; S-Adenosylmethionine; Xylose | 1979 |
The effect of nucleosides and deoxycoformycin on adenosine and deoxyadenosine inhibition of human lymphocyte activation.
Topics: Adenosine; Cells, Cultured; Coformycin; Deoxyadenosines; Humans; Leucine; Lymphocyte Activation; Nucleosides; Ribonucleosides; Thymidine; Time Factors | 1979 |
Adenosine transport and metabolism in mouse leukemia cells and in canine thymocytes and peripheral blood leukocytes.
Topics: Adenosine; Adenosine Triphosphate; Animals; Biological Transport; Coformycin; Concanavalin A; Dipyridamole; Dogs; Hypoxanthines; Kinetics; Leukemia P388; Leukemia, Experimental; Leukocytes; Mice; T-Lymphocytes | 1979 |
Potentiation by 2'-deoxycoformycin of the inhibitory effect of xylosyladenine on nuclear RNA synthesis in L1210 cells in vitro.
Topics: Adenosine; Adenosine Deaminase; Animals; Cell Nucleus; Coformycin; Leukemia L1210; Mice; Ribonucleosides; RNA, Neoplasm; Time Factors; Xylose | 1978 |
Adenosine deaminase from bovine brain: purification and partial characterization.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Brain; Cattle; Coformycin; Cytoplasm; Enzyme Stability; In Vitro Techniques; Isoelectric Point; Kinetics; Molecular Weight; Pentostatin; Temperature | 1992 |
Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cations; Coformycin; Dipyridamole; In Vitro Techniques; Inosine Monophosphate; Kinetics; Muscles; Piperazines; Rana ridibunda; Sodium-Potassium-Exchanging ATPase; Thioinosine | 1991 |
The mechanism of adenosine to inosine conversion by the double-stranded RNA unwinding/modifying activity: a high-performance liquid chromatography-mass spectrometry analysis.
Topics: Adenosine; Coformycin; Deamination; Gas Chromatography-Mass Spectrometry; Hydrolysis; Inosine; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Oxygen; RNA, Double-Stranded; Water | 1991 |
Biochemical changes induced in hairy-cell leukemia following treatment with the adenosine deaminase inhibitor 2'-deoxycoformycin.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Aged; Antineoplastic Agents; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; DNA; Humans; Interferons; Leukemia, Hairy Cell; Leukocyte Count; Male; Nucleoside Deaminases; Pentostatin; Ribonucleosides | 1986 |
Inhibition of lymphoid cell growth by adenine ribonucleotide accumulation. The role of phosphoribosylpyrophosphate-depletion induced pyrimidine starvation.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Cell Cycle; Cell Division; Cell Line; Coformycin; Humans; Hypoxanthine Phosphoribosyltransferase; Nucleoside Deaminases; Pentosephosphates; Pentostatin; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Ribonucleosides; Ribonucleotides; T-Lymphocytes | 1987 |
Adenosine potentiates mediator release from human lung mast cells.
Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Coformycin; Dipyridamole; Drug Synergism; Histamine Release; Humans; Lung; Mast Cells; Nucleosides; Pentostatin; Receptors, Purinergic; SRS-A; Time Factors; Xanthines | 1988 |
Inhibition by adenosine of histamine and leukotriene release from human basophils.
Topics: 2-Chloroadenosine; Adenosine; Basophils; Coformycin; Histamine Release; Humans; In Vitro Techniques; Pentostatin; SRS-A; Structure-Activity Relationship; Theophylline | 1989 |
IMP production by ATP-depleted adult rat heart cells. Effects of glycolysis and alpha 1-adrenergic stimulation.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; AMP Deaminase; Animals; Cells, Cultured; Coformycin; Glycolysis; Heart; Inosine; Inosine Monophosphate; Inosine Nucleotides; Kinetics; Myocardium; NAD; Phenylephrine; Rats; Receptors, Adrenergic, beta; Ribonucleosides | 1989 |
The deamination of adenosine and adenosine monophosphate in Plasmodium falciparum-infected human erythrocytes: in vitro use of 2'deoxycoformycin and AMP deaminase-deficient red cells.
Topics: Adenosine; Adenosine Monophosphate; Adult; AMP Deaminase; Animals; Coformycin; Deamination; Erythrocytes; Female; Humans; Malaria; Nucleotide Deaminases; Pentostatin; Plasmodium falciparum; Ribonucleosides | 1989 |
Stereospecific 2'-amination and 2'-chlorination of adenosine by Actinomadura in the biosynthesis of 2'-amino-2'-deoxyadenosine and 2'-chloro-2'-deoxycoformycin.
Topics: Actinomycetales; Adenosine; Amination; Anti-Bacterial Agents; Chlorine; Coformycin; Deoxyadenosines; Nucleosides; Pentostatin; Prodrugs; Stereoisomerism | 1989 |
The erythrocyte as instigator of inflammation. Generation of amidated C3 by erythrocyte adenosine deaminase.
Topics: Adenosine; Adenosine Deaminase; Adult; Ammonia; Coformycin; Complement C3; Erythrocytes; Female; Humans; Inflammation; Male; Nucleoside Deaminases; Pentostatin | 1989 |
Mechanism of adenosine triphosphate catabolism induced by deoxyadenosine and by nucleoside analogues in adenosine deaminase-inhibited human erythrocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Coformycin; Deoxyadenosines; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Nucleoside Deaminases; Pentostatin; Ribonucleosides; Structure-Activity Relationship | 1989 |
Inhibition of mast cell adenosine responsiveness by chronic exposure to adenosine receptor agonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; beta-N-Acetylhexosaminidases; Calcimycin; Cells, Cultured; Coformycin; Cyclic AMP; Dose-Response Relationship, Drug; Isoproterenol; Mast Cells; Mice; Pentostatin; Receptors, Purinergic; SRS-A; Time Factors | 1987 |
Inhibition of adenosine-metabolizing enzymes modulates mouse sperm fertilizing ability: a changing role for endogenously generated adenosine during capacitation.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Coformycin; Fertilization; Fertilization in Vitro; Male; Mice; Nucleotidases; Sperm Capacitation | 1988 |
Inhibition of utilization of hypoxanthine and guanine in cells treated with the carbocyclic analog of adenosine. Phosphates of carbocyclic nucleoside analogs as inhibitors of hypoxanthine (guanine) phosphoribosyltransferase.
Topics: Adenosine; Animals; Carcinoma, Squamous Cell; Cell Line; Coformycin; Colonic Neoplasms; Cyclic GMP; Cyclic IMP; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Nucleotides; Kinetics; Leukemia L1210; Mice; Pentosyltransferases; Ribonucleotides | 1985 |
Photoaffinity labeling of the human erythrocyte glucose transporter with 8-azidoadenosine.
Topics: Adenosine; Affinity Labels; Azides; Blood Proteins; Coformycin; Cytochalasin B; Dose-Response Relationship, Drug; Erythrocytes; Humans; Kinetics; Membrane Proteins; Molecular Weight; Monosaccharide Transport Proteins; Nucleoside Transport Proteins; Pentostatin; Phenylisopropyladenosine; Phloretin; Photochemistry; Receptors, Cell Surface; Receptors, Purinergic; Thioinosine; Uridine | 1986 |
Adenosine receptors on human T lymphocytes and human thymocytes.
Topics: 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adult; Child, Preschool; Coformycin; Cyclic AMP; Humans; In Vitro Techniques; Receptors, Purinergic; T-Lymphocytes; Thymus Gland | 1986 |
The effect of deoxycoformycin on bone marrow cells treated with adenosine and deoxyadenosine and hemopoietic growth factors.
Topics: Adenosine; Bone Marrow; Cell Division; Cells, Cultured; Coformycin; Deoxyadenosines; Growth Substances; Hematopoiesis; Hematopoietic Stem Cells; Humans; Immunosuppressive Agents; In Vitro Techniques; Pentostatin; Ribonucleosides; T-Lymphocytes | 1988 |
Endogenous and exogenous adenosine inhibit granulocyte aggregation without altering the associated rise in intracellular calcium concentration.
Topics: Adenosine; Adenosine Deaminase; Body Fluids; Calcium; Cell Aggregation; Coformycin; Complement Activation; Granulocytes; Humans; Intracellular Fluid; N-Formylmethionine Leucyl-Phenylalanine; Pentostatin; Zymosan | 1988 |
Effects of deoxycoformycin on adenosine, inosine, hypoxanthine, xanthine, and uric acid release from the hypoxemic rat cerebral cortex.
Topics: Adenosine; Animals; Cerebral Cortex; Coformycin; Hypoxanthine; Hypoxanthines; Hypoxia; Inosine; Male; Pentostatin; Rats; Rats, Inbred Strains; Ribonucleosides; Uric Acid; Xanthine; Xanthines | 1988 |
Adenosine induction of rapid catabolism of adenine ribonucleotides and independent elevation of the ATP content in quiescent mouse fibroblasts.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Line; Coformycin; Deoxyadenosines; Guanosine Triphosphate; Inosine Monophosphate; Interphase; Kinetics; Mice | 1988 |
Degradation of adenosine by extracellular adenosine deaminase in the rat duodenum.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Coformycin; Dilazep; Duodenum; In Vitro Techniques; Male; Muscle Contraction; Nucleoside Deaminases; Pentostatin; Rats; Rats, Inbred Strains | 1988 |
Cultures of glial cells release purines under field electrical stimulation: the possible ionic mechanisms.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Brain; Cells, Cultured; Coformycin; Electric Stimulation; Neuroglia; Nucleotides; Pentostatin; Pharmacology; Rats; Reference Values; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Verapamil | 1988 |
Interstitial transudate concentration of adenosine and inosine in rat and guinea pig hearts.
Topics: Adenosine; Animals; Coformycin; Coronary Circulation; Dipyridamole; Exudates and Transudates; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Inosine; Myocardium; Oxygen Consumption; Perfusion; Rats | 1988 |
Adenosine transport by the lung.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Azaguanine; Biological Transport, Active; Coformycin; Colchicine; Dipyridamole; Glucose; Kinetics; Lung; Male; Ouabain; Rats; Rats, Inbred Strains | 1988 |
Energy metabolism in adenosine deaminase-inhibited human erythrocytes.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Triphosphate; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Energy Metabolism; Erythrocytes; Glycolysis; Humans; Hypoxanthine; Hypoxanthines; Nucleoside Deaminases; Pentostatin; Ribonucleosides | 1986 |
Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells.
Topics: Adenosine; Adenosine Deaminase; Animals; Cloning, Molecular; Coformycin; Cricetinae; Drug Resistance; Gene Amplification; Gene Expression Regulation; Genetic Vectors; Mice; Nucleoside Deaminases; Pentostatin; RNA, Messenger | 1986 |
Specificity of 2'-deoxycoformycin inhibition of adenosine metabolism in intact human skin fibroblasts.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Cells, Cultured; Coformycin; Dose-Response Relationship, Drug; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine; Nucleoside Deaminases; Pentostatin; Phosphorylation; Ribonucleosides; Skin | 1986 |
Changes in nucleoside transport of HL-60 human promyelocytic cells during N,N-dimethylformamide induced differentiation.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Cell Differentiation; Cell Line; Coformycin; Deoxyadenosines; Dimethylformamide; Humans; Leukemia, Myeloid, Acute; Nucleosides; Pentostatin; Purines; Thioinosine | 1986 |
Transport and metabolism of adenosine in human erythrocytes: effect of transport inhibitors and regulation by phosphate.
Topics: Adenine Phosphoribosyltransferase; Adenosine; Adenosine Kinase; Biological Transport; Coformycin; Dilazep; Dipyridamole; Erythrocytes; Humans; Pentostatin; Phosphates; Phosphorylation; Thioinosine | 1986 |
Purine metabolism by guinea-pig ileum.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Chromatography, High Pressure Liquid; Coformycin; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; NAD; Pentostatin; Purines; Receptors, Purinergic | 1986 |
Inhibition of 3H-thymidine incorporation by adenosine and deoxyadenosine in human peripheral lymphocytes and malignant lymphoid cell lines.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Cell Line; Cells, Cultured; Coformycin; Deoxyadenosines; DNA; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Pentostatin; Thymidine | 1986 |
S-adenosylmethionine metabolism as a target for adenosine toxicity.
Topics: Adenosine; Adenosine Kinase; Animals; Cell Line; Coformycin; Drug Resistance; Lymphoma; Methionine Adenosyltransferase; Mice; Pentostatin; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Pathways of adenine nucleotide catabolism in human erythrocytes.
Topics: Adenine; Adenine Nucleotides; Adenosine; Blood Glucose; Coformycin; Erythrocytes; Humans; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxanthines; Pentostatin; Phosphates; Tubercidin | 1986 |
Inhibitor of 2', 5'-oligoadenylate synthetase induced in human T lymphoblastoid cell line treated with deoxyadenosine, deoxycoformycin and interferon.
Topics: 2',5'-Oligoadenylate Synthetase; Adenosine; Cell Line; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Enzyme Induction; Homocysteine; Humans; Interferon Type I; Pentostatin; Ribonucleosides; T-Lymphocytes; Vidarabine | 1986 |
An involvement of adenosine in cerebral blood flow regulation during hypercapnia.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Cerebrovascular Circulation; Coformycin; Dipyridamole; Hypercapnia; Male; Pentostatin; Rats; Rats, Inbred Strains | 1987 |
Enhancement of biotinidase activity in mouse serum by inhibitors of methylation.
Topics: Adenine; Adenosine; Amidohydrolases; Animals; Biotinidase; Coformycin; Ethionine; Female; Liver; Methylation; Mice; Pentostatin; Vidarabine | 1987 |
Biosynthesis of 2'-deoxycoformycin: evidence for ring expansion of the adenine moiety of adenosine to a tetrahydroimidazo[4,5-d][1,3]diazepine system.
Topics: Adenosine; Antineoplastic Agents; Carbon Radioisotopes; Coformycin; Indicators and Reagents; Inosine; Magnetic Resonance Spectroscopy; Pentostatin; Ribonucleosides | 1987 |
[Characteristics of adenosine activity on adenine nucleotide metabolism of rat thymocytes].
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biological Transport; Coformycin; Inosine; Inosine Monophosphate; Pentostatin; Rats; Rats, Inbred Strains; Thymus Gland | 1985 |
Adenine nucleotide metabolism and nucleoside transport in human erythrocytes under ATP depletion conditions.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Biological Transport; Coformycin; Erythrocytes; Humans; Iodoacetamide; Iodoacetates; Iodoacetic Acid; Kinetics; Pentostatin; Tritium | 1985 |
Differential antiproliferative actions of 2',5' oligo A trimer core and its cordycepin analogue on human tumor cells.
Topics: Adenine Nucleotides; Adenosine; Cell Division; Cell Line; Coformycin; Culture Techniques; Dose-Response Relationship, Drug; Drug Resistance; Humans; Neoplasms; Oligodeoxyribonucleotides; Oligonucleotides; Oligoribonucleotides; Pentostatin | 1985 |
Adenosine uptake, transport, and metabolism in human erythrocytes.
Topics: Adenosine; Adenosine Kinase; Biological Transport; Cell Membrane; Coformycin; Erythrocytes; Humans; Intracellular Fluid; Kinetics; Pentostatin; Phosphorylation; Time Factors | 1985 |
Effects of nucleoside transport inhibitors on the salvage and toxicity of adenosine and deoxyadenosine in L1210 and P388 mouse leukemia cells.
Topics: Adenosine; Animals; Biological Transport; Coformycin; Deoxyadenosines; Dipyridamole; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Pentostatin; Thioinosine | 1985 |
Inhibition of interleukin-2 messenger RNA in mouse lymphocytes by 2'-deoxycoformycin and adenosine metabolites.
Topics: Adenosine; Animals; Coformycin; Female; Immunosuppressive Agents; Interleukin-2; Kinetics; Lymphocytes; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Pentostatin; Ribonucleosides; RNA, Messenger; Spleen | 1985 |
Effects of adenosine deaminase inhibitors on lymphocyte-mediated cytolysis.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Line; Coformycin; Cytotoxicity, Immunologic; Immunity, Cellular; Immunosuppressive Agents; Leukemia; Mice; Nucleoside Deaminases; Pentostatin; T-Lymphocytes, Cytotoxic | 1985 |
An analysis of multiple mechanisms of adenosine toxicity in baby hamster kidney cells.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cell Adhesion; Cell Line; Coformycin; Drug Resistance; Drug Synergism; Guinea Pigs; Homocysteine; Kidney; Nucleotides; Pentostatin; Ribonucleotide Reductases; S-Adenosylhomocysteine; Uridine | 1985 |
Purification and characterization of adenosine deaminase from a genetically enriched mouse cell line.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Cell Line; Coformycin; Electrophoresis, Polyacrylamide Gel; Gene Amplification; Half-Life; Immunosorbent Techniques; Isoelectric Focusing; Kinetics; Mice; Molecular Weight; Mutation; Nucleoside Deaminases; Pentostatin | 1985 |
Purine metabolic enzymes in lymphocytes. IV. Effects of enzyme inhibitors and enzyme substrates on the blastogenic responses of human lymphocytes.
Topics: Adenosine; Adenosine Deaminase; Allopurinol; Coformycin; Enzyme Inhibitors; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Lymphocyte Activation; Lymphocytes; Mitogens; Purine-Nucleoside Phosphorylase; Purines; Xanthine Oxidase | 1985 |
2-Chloroadenosine: a selective lethal effect to mouse macrophages and its mechanism.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Ascitic Fluid; Cell Line; Cell Membrane; Cell Survival; Coformycin; Female; Iodoacetates; Iodoacetic Acid; Kinetics; Macrophages; Methylation; Mice; Purine Nucleosides | 1985 |
Study on the inhibition of adenosine deaminase.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Cattle; Chemical Phenomena; Chemistry; Coformycin; Nucleoside Deaminases; Ribonucleosides; Structure-Activity Relationship; X-Ray Diffraction | 1985 |
Hemodynamic effects of potentially useful antineoplastic agents.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Coformycin; Dose-Response Relationship, Drug; Electrocardiography; Female; Formycins; Hemodynamics; Hypotension; Pentostatin; Rats; Rats, Inbred Strains; Vidarabine Phosphate | 1983 |
Adenosine-resistant Chinese hamster fibroblast variants with hyperactive adenosine-deaminase: an analysis of the protection against exogenous adenosine afforded by increased activity of the deamination pathway.
Topics: Adenosine; Adenosine Deaminase; Animals; Cell Line; Coformycin; Cricetinae; Cricetulus; Drug Resistance; Fibroblasts; Hypoxanthine; Hypoxanthines; Inosine; Models, Chemical; Nucleoside Deaminases; Phosphoribosyl Pyrophosphate; Purines | 1984 |
Potentiation of antiaggregating activity of adenosine by a phosphodiesterase inhibitor, EG626 (oxagrelate), in human platelets in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine Deaminase Inhibitors; Adenylyl Cyclases; Coformycin; Collagen; Cyclic AMP; Drug Synergism; Humans; In Vitro Techniques; Male; Pentostatin; Phosphodiesterase Inhibitors; Phthalazines; Platelet Aggregation; Pyridazines | 1984 |
Purine modulation of the hormonal response of the rat Sertoli cell in culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Binding, Competitive; Bucladesine; Cells, Cultured; Coformycin; Cyclic AMP; Follicle Stimulating Hormone; Isoproterenol; Male; Pentostatin; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Sertoli Cells | 1984 |
Adenosine kinase from human erythrocytes: determination of the conditions required for assay in crude hemolystates.
Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Adult; Cations, Divalent; Chromatography, Thin Layer; Coformycin; Erythrocytes; Hemolysis; Humans; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methods; Phosphotransferases; Reference Values | 1980 |
Cyclic AMP-generating systems in cell-free preparations from guinea pig cerebral cortex: loss of adenosine and amine responsiveness due to low levels of endogenous adenosine.
Topics: Adenosine; Adenosine Deaminase; Amines; Animals; Cell-Free System; Cerebral Cortex; Coformycin; Cyclic AMP; Guinea Pigs; Histamine; Male; Norepinephrine; Pentostatin | 1980 |
Adenosine and cyclic AMP in rat cerebral cortical slices: effects of adenosine uptake inhibitors and adenosine deaminase inhibitors.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Brain; Catecholamines; Coformycin; Cyclic AMP; Dipyridamole; In Vitro Techniques; Male; Nucleoside Deaminases; Pentostatin; Rats; Veratridine | 1981 |
Clinical pharmacology of deoxycoformycin.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adolescent; Adult; Aged; Bronchitis; Coformycin; Coma; Conjunctivitis; Deoxyadenosines; Female; Humans; Kidney Diseases; Leukemia, Lymphoid; Lymphoma; Male; Middle Aged; Mycosis Fungoides; Nucleoside Deaminases; Pentostatin; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Ribonucleosides | 1981 |
Adenosine production inside rat polymorphonuclear leucocytes.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Chromatography, High Pressure Liquid; Coformycin; Neutrophils; Nucleotidases; Pentostatin; Rats; Tubercidin | 1981 |
Adenine-derived purines increase adenosine triphosphate (ATP) levels in the luteal cell: evidence that cell levels of ATP may limit the stimulation of adenosine 3',5'-monophosphate accumulation by luteinizing hormone.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Coformycin; Corpus Luteum; Cyclic AMP; Dinoprost; Dose-Response Relationship, Drug; Female; Luteinizing Hormone; Prostaglandins F; Purine Nucleosides; Rats | 1983 |
Effect of N6-methyladenosine on fat-cell glucose metabolism. Evidence for two modes of action.
Topics: Adenosine; Adipose Tissue; Animals; Coformycin; Cyclic AMP; Fatty Acids; Glucose; Glycerol; In Vitro Techniques; Male; Nucleosides; Oxidation-Reduction; Pentostatin; Rats; Rats, Inbred Strains; Theophylline | 1982 |
Adenosine metabolism in wild-type and enzyme-deficient variants of Chinese hamster ovary and Novikoff rat hepatoma cells.
Topics: 2-Aminopurine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Animals; Cell Division; Cell Line; Cell-Free System; Coformycin; Cricetinae; Female; Kinetics; Liver Neoplasms, Experimental; Ovary; Pentostatin; Phosphorylation; Phosphotransferases; Purine-Nucleoside Phosphorylase; Rats; Tubercidin | 1983 |
Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Calcimycin; Cell Aggregation; Coformycin; Cytochalasin B; Cytoplasmic Granules; Depression, Chemical; Dipyridamole; Humans; Methylation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentostatin; Superoxides | 1983 |
Neplanocin A. A cyclopentenyl analog of adenosine with specificity for inhibiting RNA methylation.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Coformycin; Colonic Neoplasms; DNA Replication; Humans; Kinetics; Methylation; Pentostatin; Protein Biosynthesis; Ribonucleosides; RNA, Ribosomal; Transcription, Genetic | 1984 |
Adenosine deaminase in malaria infected erythrocytes: unique parasite enzyme presents a new therapeutic target.
Topics: Adenosine; Adenosine Deaminase; Animals; Coformycin; Erythrocytes; Humans; Macaca mulatta; Malaria; Male; Nucleoside Deaminases; Pentostatin; Plasmodium | 1984 |
Evidence for distinct catabolic pathways of adenine ribonucleotides and deoxyribonucleotides in human T lymphoblastoid cells.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Cell Line; Coformycin; Deoxyadenine Nucleotides; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine; Kinetics; Pentostatin; Structure-Activity Relationship; T-Lymphocytes | 1984 |
The mechanism of cell-mediated cytotoxicity. III. Protease-specific inhibitors preferentially block later events in cytotoxic T lymphocyte-mediated lysis than do inhibitors of methylation or thiol-reactive agents.
Topics: Adenosine; alpha 1-Antichymotrypsin; Animals; Bridged Bicyclo Compounds; Calcium; Chymotrypsin; Coformycin; Cytotoxicity, Immunologic; Deoxyadenosines; Methylation; Mice; Mice, Inbred Strains; Pentostatin; Peptide Hydrolases; Sulfhydryl Compounds; T-Lymphocytes, Cytotoxic; Time Factors; Tyrosine | 1983 |
Differential production of deoxyadenosine by human T and B lymphoblasts.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; B-Lymphocytes; Cell Line; Coformycin; Deoxyadenosines; Humans; Interphase; Lymphocyte Activation; Lymphoma, Large B-Cell, Diffuse; Pentostatin; T-Lymphocytes | 1983 |
Effects of hypoxia on the guinea-pig myocardium following inhibition of adenosine deaminase by coformycin.
Topics: Action Potentials; Adenosine; Adenosine Deaminase Inhibitors; Animals; Coformycin; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nucleoside Deaminases; Oxygen; Ribonucleosides; Time Factors | 1984 |
Adenosine and compensatory renal growth.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Division; Coformycin; Hypertrophy; Kidney; Male; Nephrectomy; Rats; Rats, Inbred Strains | 1983 |
Clinical pharmacology of arabinofuranosyladenine in combination with deoxycoformycin.
Topics: Adenosine; Adult; Antineoplastic Agents; Coformycin; Deoxyadenosines; Drug Administration Schedule; Drug Therapy, Combination; Half-Life; Humans; Kinetics; Leukemia; Male; Pentostatin; Ribonucleosides; Vidarabine | 1983 |
S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine.
Topics: Acute Disease; Adenosine; Adult; Coformycin; Deoxyadenosines; Drug Resistance; Drug Therapy, Combination; Erythrocytes; Homocysteine; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Pentostatin; Ribonucleosides; S-Adenosylhomocysteine; Time Factors; Vidarabine | 1983 |
Effect of 2'-deoxycoformycin infusion on S-adenosylhomocysteine hydrolase and the amount of S-adenosylhomocysteine and related compounds in tissues of mice.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; Animals; Coformycin; Deoxyadenosines; Homocysteine; Hydrolases; Infusions, Parenteral; Jejunum; Kidney; Kinetics; Liver; Mice; Nucleoside Deaminases; Organ Specificity; Pentostatin; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat.
Topics: Adenosine; Adenosine Kinase; Animals; Cells, Cultured; Coformycin; Heart; In Vitro Techniques; Male; Myocardium; Neutrophils; Pentostatin; Perfusion; Rats; Rats, Inbred Strains; Tubercidin | 1983 |
Enhancement of the antitumor activity of N6-(delta 2-isopentenyl)adenosine against cultured L-1210 leukemia cells by pentostatin using a polymeric delivery system.
Topics: Adenosine; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Coformycin; Drug Synergism; Isopentenyladenosine; Leukemia L1210; Mice; Pentostatin; Polymers; Ribonucleosides | 1983 |
Neurotoxicity of deoxycoformycin: effect of constant infusion on adenosine deaminase, adenosine, 2'-deoxyadenosine and monoamines in the mouse brain.
Topics: Adenosine; Adenosine Deaminase; Animals; Biogenic Amines; Brain Chemistry; Coformycin; Deoxyadenosines; Dopamine; Mice; Norepinephrine; Nucleoside Deaminases; Pentostatin; Ribonucleosides; Serotonin; Time Factors | 1983 |
Increased cytotoxicity of N6-(delta 2-isopentenyl)adenosine in combination with pentostatin against L-1210 leukemia cells.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Coformycin; Isopentenyladenosine; Leukemia L1210; Mice; Pentostatin; Ribonucleosides | 1983 |
The effects of adenosine and 2'-deoxycoformycin on sleep and wakefulness in rats.
Topics: Adenosine; Adenosine Deaminase; Animals; Coformycin; Electroencephalography; Electromyography; Injections, Intraventricular; Male; Pentostatin; Rats; Rats, Inbred Strains; Ribonucleosides; Sleep; Sleep, REM; Wakefulness | 1983 |
Evidence for the conversion of adenosine to 2'-deoxycoformycin by Streptomyces antibioticus.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Carbon Radioisotopes; Chromatography, Thin Layer; Coformycin; Cytarabine; Glycine; Pentostatin; Ribonucleosides; Streptomyces | 1984 |
Stimulation of ATP synthesis in hypothermically perfused dog kidneys by adenosine and PO4.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Coformycin; Cold Temperature; Dogs; Kidney; Mitochondria; Organ Preservation; Pentostatin; Perfusion; Phosphates; Potassium; Potassium Compounds | 1984 |
Measurement of adenosine metabolism and uptake in smooth muscle and effects of adenosine transport inhibitors.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Cattle; Coformycin; Coronary Vessels; Dipyridamole; Dose-Response Relationship, Drug; Female; Guanosine; Guinea Pigs; In Vitro Techniques; Inosine; Intestinal Mucosa; Male; Muscle, Smooth; Pentostatin; Rabbits; Thioinosine; Thionucleosides | 1984 |
Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo.
Topics: Adenosine; Adolescent; Cell Survival; Coformycin; Deoxyadenosines; Enzyme Inhibitors; Humans; Leukemia, Lymphoid; Male; T-Lymphocytes | 1980 |
Animal model for immune dysfunction associated with adenosine deaminase deficiency.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antibody Formation; B-Lymphocytes; Coformycin; Disease Models, Animal; Immunity, Cellular; Immunologic Deficiency Syndromes; Mice; Nucleoside Deaminases; Pentostatin; Ribonucleosides; T-Lymphocytes | 1980 |
Resistance of pokeweed mitogen-stimulated B cells to inhibition by deoxyadenosine.
Topics: Adenosine; B-Lymphocytes; Cell Differentiation; Cell Line; Coformycin; Deoxyadenosines; Humans; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; Pentostatin; Pokeweed Mitogens; T-Lymphocytes; Thymidine | 1980 |
ATP depletion as a consequence of adenosine deaminase inhibition in man.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Aged; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Erythrocytes; Humans; Nucleoside Deaminases; Pentostatin; Ribonucleosides; Sezary Syndrome | 1980 |
An assay of deoxyadenosine and adenosine in human plasma by HPLC.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Chromatography, High Pressure Liquid; Coformycin; Deoxyadenosines; Humans; Kinetics; Pentostatin | 1980 |
Adenosine stimulation of uphill adenine transport in L1210 leukemia cells. Evidence for a novel countertransport mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Coformycin; Dipyridamole; Kinetics; Leukemia L1210; Mice; Mice, Inbred Strains; Pentostatin | 1981 |
2-Deoxycoformycin inhibition of intracellular phosphorylation of adenosine in Novikoff rat hepatoma cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cell Membrane; Cells, Cultured; Coformycin; Deamination; Liver Neoplasms, Experimental; Pentostatin; Phosphorylation; Rats; Ribonucleosides | 1981 |
Deoxycoformycin: neurological toxicity.
Topics: Adenosine; Adult; Coformycin; Deoxyadenosines; Electroencephalography; Humans; Male; Nervous System Diseases; Pentostatin; Ribonucleosides | 1981 |
Levels of 2'-deoxycoformycin, adenosine, and deoxyadenosine in patients with acute lymphoblastic leukemia.
Topics: Adenosine; Adolescent; Adult; Child; Child, Preschool; Coformycin; Deoxyadenosines; Drug Evaluation; Female; Humans; Leukemia, Lymphoid; Male; Pentostatin; Ribonucleosides; Time Factors | 1981 |
Consequences of adenosine deaminase deficiency on thymocyte metabolism.
Topics: Adenosine; Adenosine Deaminase; Animals; Coformycin; Concanavalin A; Deoxyadenosines; Dose-Response Relationship, Drug; Female; Lymphocyte Activation; Male; Nucleoside Deaminases; Pentostatin; Rats; Rats, Inbred Strains; T-Lymphocytes | 1981 |
Comparison of the effects on cultured L1210 leukemia cells of the ribosyl, 2'-deoxyribosyl, and xylosyl homologs of tubercidin and adenosine alone or in combination with 2'-deoxycoformycin.
Topics: Adenosine; Amino Acids; Animals; Cell Division; Cell Survival; Cells, Cultured; Coformycin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Leukemia L1210; Mice; Mice, Inbred Strains; Nucleotides; Pentostatin; Ribonucleosides; Tubercidin | 1982 |
Suppression of human lymphocyte DNA and protein synthesis in vitro by adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase inhibitors, 2'-deoxycoformycin (DCF) and erythro-9-(2-hydroxy-3-nonyl) adenine
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Blood Proteins; Coformycin; DNA; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Pentostatin; Phytohemagglutinins | 1982 |
Renal handling of 2'-deoxyadenosine and adenosine in humans and mice.
Topics: Adenine; Adenosine; Animals; Blood Proteins; Child, Preschool; Chromatography, High Pressure Liquid; Coformycin; Creatinine; Deoxyadenosines; Humans; Infant; Kidney; Male; Mice; Pentostatin; Protein Binding; Species Specificity | 1982 |
Biochemical pharmacology and toxicology of 8-azaadenosine alone and in combination with 2'-deoxycoformycin (pentostatin).
Topics: Adenosine; Animals; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Coformycin; Drug Interactions; Female; Lethal Dose 50; Leukocyte Count; Liver; Male; Mice; Pentostatin; Rats; Ribonucleosides; Thymus Gland | 1982 |
Pyrrolopyrimidine lethality in relation to ribonucleic acid synthesis in sarcoma 180 cells in vitro.
Topics: Adenosine; Animals; Cells, Cultured; Coformycin; Mice; Pentostatin; Pyrimidine Nucleosides; RNA, Neoplasm; Sarcoma 180; Time Factors; Uridine | 1982 |
Adenosine and deoxyadenosine toxicity in colony assay systems for human T-lymphocytes, B-lymphocytes, and granulocytes.
Topics: Adenosine; B-Lymphocytes; Bone Marrow Cells; Cell Survival; Coformycin; Colony-Forming Units Assay; Deoxyadenosines; Granulocytes; Humans; Leukocytes; Pentostatin; T-Lymphocytes | 1982 |
Activated T lymphocytes resist the toxic effects of the adenosine deaminase inhibitor, 2-deoxycoformycin.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; B-Lymphocytes; Cell Differentiation; Coformycin; Concanavalin A; Cytotoxicity, Immunologic; Deoxyadenosines; Immunologic Memory; Lymphocyte Activation; Male; Nucleoside Deaminases; Rats; Ribonucleosides; T-Lymphocytes | 1982 |
Capping and adenosine metabolism. Genetic and pharmacologic studies.
Topics: Adenosine; Adenosine Deaminase; Animals; Bone Marrow Transplantation; Coformycin; Contractile Proteins; Homocysteine; Humans; Immunologic Capping; Lymphocytes; Mice; Tubercidin | 1980 |
Bone marrow transplantation only partially restores purine metabolites to normal in adenosine deaminase-deficient patients.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Bone Marrow Transplantation; Child; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Erythrocytes; Follow-Up Studies; Humans; Hydrolases; Monocytes; Nucleoside Deaminases; Pentostatin; Purines | 1981 |
Potentiation of the myocardial actions of adenosine in the presence of coformycin, a specific inhibitor of adenosine deaminase.
Topics: Action Potentials; Adenosine; Adenosine Deaminase Inhibitors; Animals; Coformycin; Dipyridamole; Drug Interactions; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Nucleoside Deaminases; Ribonucleosides | 1982 |
Apoptosis induced by adenosine in human leukemia HL-60 cells.
Topics: Adenine Nucleotides; Adenosine; Apoptosis; Cell Line; Coformycin; Deoxyadenosines; Deoxyguanosine; DNA, Neoplasm; Guanosine; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Nucleosomes; Poly Adenosine Diphosphate Ribose; Receptors, Purinergic P1; Thymidine; Tumor Cells, Cultured | 1994 |
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
Topics: Adenosine; Animals; Coformycin; Colonic Neoplasms; Enzyme Inhibitors; Extracellular Space; Female; Fibrosarcoma; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Microdialysis; Neoplasm Transplantation; Time Factors; Tubercidin; Tumor Cells, Cultured | 1997 |
Evidence for a low temperature transition state binding preference in bovine adenosine deaminase.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Binding Sites; Catalysis; Cattle; Coformycin; Cold Temperature; Enzyme Inhibitors; Kinetics; Protein Binding; Spleen; Temperature | 1998 |
Delayed production of adenosine underlies temporal modulation of swimming in frog embryo.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coformycin; Embryo, Nonmammalian; Locomotion; Models, Biological; Models, Statistical; Motor Activity; Neurons; Spinal Cord; Swimming; Time Factors; Xenopus | 1998 |
Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Amobarbital; Anaerobiosis; Animals; Astrocytes; Cell Hypoxia; Cell Survival; Coformycin; Dose-Response Relationship, Drug; Electron Transport; Enzyme Inhibitors; GABA Modulators; Glioma; Glucose; Glycolysis; Guanine Nucleotides; Guanosine; Hybrid Cells; Inosine; Inosine Monophosphate; Ischemia; Lactic Acid; Mitochondria; Neuroprotective Agents; Oligodendroglia; Pentosyltransferases; Purine Nucleosides; Rats | 1998 |
The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.
Topics: Adenosine; Adenosine Triphosphate; AMP Deaminase; Coformycin; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Formycins; Herbicides; Inhibitory Concentration 50; Phosphorylation; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship | 1999 |
Adenosine-mediated killing of cultured epithelial cancer cells.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Coformycin; Deoxyadenosines; Dipyridamole; Enzyme Inhibitors; Female; Humans; Kinetics; Ovarian Neoplasms; Pentostatin; Tumor Cells, Cultured | 2000 |
Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Biosensing Techniques; Calcium; Cell Hypoxia; Coformycin; Enzyme Inhibitors; Evaluation Studies as Topic; Excitatory Postsynaptic Potentials; Female; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Pentosyltransferases; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Synaptic Transmission; Xanthine Oxidase | 2000 |
Enhancement of cellular adenosine triphosphate levels in PC12 cells by extracellular adenosine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coformycin; Dipyridamole; PC12 Cells; Rats; Receptors, Purinergic P1; Theophylline; Tubercidin | 2002 |
Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Apoptosis; Biological Transport; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Division; Cell Line; Cell Line, Tumor; Coformycin; Dipyridamole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Nucleosides; Oligonucleotide Array Sequence Analysis; Receptor, Adenosine A3; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uridine Triphosphate | 2003 |
Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Brain; Coformycin; Extracellular Space; Male; Meninges; Prosencephalon; Rats; Sleep; Tissue Distribution | 2003 |
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine Deaminase Inhibitors; Animals; Coformycin; Enzyme Inhibitors; Histamine; Hypothalamic Area, Lateral; Male; Mice; Mice, Knockout; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Histamine H1; Sleep Stages | 2008 |
Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes.
Topics: Actinobacteria; Adenosine; Anti-Bacterial Agents; Bacterial Proteins; Biosynthetic Pathways; Coformycin; GMP Reductase; Purine Nucleosides | 2018 |