coenzyme-q10 and 5-hydroxy-6-8-11-14-eicosatetraenoic-acid

Neutrophils release leukotriene (LT)B. This study evaluated the independent and combined effects of n-3 FA and CoQ supplementation on neutrophil leukotrienes, the pro-inflammatory eicosanoid 5-hydroxyeicosatetraenoic acid (5-HETE), SPM, and plasma MPO, in patients with CKD.. In a double-blind, placebo-controlled intervention of factorial design, 85 patients with CKD were randomized to either n-3 FA (4 g), CoQ (200 mg), both supplements, or control (4 g olive oil), daily for 8 weeks. Plasma MPO and calcium ionophore-stimulated neutrophil release of LTs, 5-HETE and SPM were measured at baseline and after 8 weeks.. Seventy four patients completed the intervention. n-3 FA, but not CoQ, significantly increased neutrophil LTB. n-3 FA supplementation in patients with CKD leads to increased neutrophil release of LTB

Topics: Adult; Aged; Dietary Supplements; Double-Blind Method; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Humans; Hydroxyeicosatetraenoic Acids; Inflammation Mediators; Leukotriene B4; Male; Middle Aged; Neutrophils; Peroxidase; Renal Insufficiency, Chronic; Ubiquinone