cochleamycin-a and malic-acid

cochleamycin-a has been researched along with malic-acid* in 1 studies

Other Studies

1 other study(ies) available for cochleamycin-a and malic-acid

Article	Year
Studies aimed at the total synthesis of the antitumor antibiotic cochleamycin A. An enantioselective biosynthesis-based pathway to the AB bicyclic core. Organic letters, 2002, Jan-24, Volume: 4, Issue:2 [reaction: see text] A convergent, highly enantioselective synthesis of the fully functionalized AB sector of cochleamycin A is described. A pair of building blocks, crafted from L-malic and L-ascorbic acids, are conjoined in a manner that gives rise to an (E,Z,E)-1,6,8-nonatriene. On heating, the latter undergoes stereocontrolled intramolecular Diels-Alder cyclization via an endo transition state. Topics: Antibiotics, Antineoplastic; Ascorbic Acid; Cyclization; Cyclopentanes; Lactones; Malates; Polyenes; Stereoisomerism	2002

Article

Year

Studies aimed at the total synthesis of the antitumor antibiotic cochleamycin A. An enantioselective biosynthesis-based pathway to the AB bicyclic core.

Organic letters, 2002, Jan-24, Volume: 4, Issue:2

[reaction: see text] A convergent, highly enantioselective synthesis of the fully functionalized AB sector of cochleamycin A is described. A pair of building blocks, crafted from L-malic and L-ascorbic acids, are conjoined in a manner that gives rise to an (E,Z,E)-1,6,8-nonatriene. On heating, the latter undergoes stereocontrolled intramolecular Diels-Alder cyclization via an endo transition state.

Topics: Antibiotics, Antineoplastic; Ascorbic Acid; Cyclization; Cyclopentanes; Lactones; Malates; Polyenes; Stereoisomerism

2002