Compounds > cocaine

cocaine and vigabatrin

cocaine has been researched along with vigabatrin in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (42.11)	18.2507
2000's	9 (47.37)	29.6817
2010's	2 (10.53)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Alexoff, DL; Brodie, JD; Chaurasia, CS; Chen, CE; Clarkson, FA; Dewey, SL; Fowler, JS; Porter, SP; Russo, NB; Straughter-Moore, RM; Tedeschi, D; Volkow, ND	1
Dewey, SL; Kornetsky, C; Kushner, SA	2
Dewey, SL; Morgan, AE	1
Ashby, CR; Brodie, JD; Dewey, SL; Fowler, JS; Gardner, EL; Horan, B; Kushner, SA; Logan, J; Morgan, AE; Volkow, ND	1
Ashby, CR; Borda, T; Brodie, JD; Dewey, SL; Gerasimov, MR; Kushner, S; Morgan, AE; Ngosuwan, J; Rohatgi, R	1
Abumrad, N; Ahmed, N; Ajmal, M; Dewey, S; Fowler, J; Molina, PE; Volkow, N	1
Dewey, SL; Gerasimov, MR	1
Bermel, RA; Brodie, JD; Dewey, SL; Gerasimov, MR; Schiffer, WK	1
Ashby, CR; Brodie, JD; Dewey, SL; Gardner, EL; Gerasimov, MR; Lennon, IC; Marsteller, DA; Schiffer, WK; Taylor, SJ	1
Dewey, SL; Mackler, SA; O'Brien, CP; Stromberg, MF; Volpicelli, JR	1
Ashby, CR; Brodie, JD; Dewey, SL; Gardner, EL; Highfield, D; Horan, BA; Schiffer, WK	1
Dewey, SL; Marsteller, D; Schiffer, WK	1
Dewey, SL; Logan, J; Schiffer, WK	1
Filip, M; Frankowska, M; Gołda, A; Przegaliński, E; Vetulani, J; Zaniewska, M	2
Ashby, CR; Brodie, JD; Dewey, SL; Gardner, EL; Gilbert, JG; Li, X; Pak, AC; Peng, XQ; Xi, ZX	1
Bickel, WK; Ciraulo, DA; Galloway, GP; Gorodetzky, CW; Jasinski, D; Lewis, D; Miller, SR; Roache, JD; Segal, SD; Sheehan, M; Somoza, EC; Somoza, P; Watson, DW; Winhusen, T; Winship, D	1

Trials

1 trial(s) available for cocaine and vigabatrin

Article	Year
A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence. JAMA psychiatry, 2013, Volume: 70, Issue:6 Topics: Adult; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; GABA Agents; Humans; Male; Medication Adherence; Middle Aged; Treatment Outcome; Vigabatrin	2013

Other Studies

18 other study(ies) available for cocaine and vigabatrin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
GABAergic attenuation of cocaine-induced dopamine release and locomotor activity. Synapse (New York, N.Y.), 1997, Volume: 25, Issue:4 Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Corpus Striatum; Dopamine; Enzyme Inhibitors; Ethanol; GABA Modulators; gamma-Aminobutyric Acid; Lorazepam; Male; Microdialysis; Motor Activity; Rats; Rats, Sprague-Dawley; Time Factors; Vigabatrin	1997
Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds. Psychopharmacology, 1997, Volume: 133, Issue:4 Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Reward; Vigabatrin	1997
Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine. Synapse (New York, N.Y.), 1998, Volume: 28, Issue:1 Topics: Animals; Cocaine; Dopamine; gamma-Aminobutyric Acid; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Vigabatrin	1998
A novel strategy for the treatment of cocaine addiction. Synapse (New York, N.Y.), 1998, Volume: 30, Issue:2 Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Catalepsy; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Female; Food; gamma-Aminobutyric Acid; Male; Motor Activity; Papio; Rats; Rats, Sprague-Dawley; Vigabatrin	1998
Implication of the GABA(B) receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine. Synapse (New York, N.Y.), 1999, Volume: 31, Issue:2 Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Male; Morpholines; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Vigabatrin	1999
The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2 Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Conditioning, Operant; Enzyme Inhibitors; Food; gamma-Aminobutyric Acid; Male; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration; Vigabatrin	1999
Co-administration of gamma-vinyl GABA and cocaine: preclinical assessment of safety. Life sciences, 1999, Volume: 65, Issue:11 Topics: 4-Aminobutyrate Transaminase; Alanine Transaminase; Animals; Cocaine; Electrocardiography; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hemodynamics; Lactic Acid; Liver; Male; Rats; Rats, Sprague-Dawley; Vigabatrin	1999
Gamma-vinyl gamma-aminobutyric acid attenuates the synergistic elevations of nucleus accumbens dopamine produced by a cocaine/heroin (speedball) challenge. European journal of pharmacology, 1999, Sep-03, Volume: 380, Issue:1 Topics: 4-Aminobutyrate Transaminase; Analysis of Variance; Animals; Cocaine; Dopamine; Drug Synergism; Enzyme Inhibitors; Heroin; Male; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Time Factors; Vigabatrin	1999
Stereoselective inhibition of dopaminergic activity by gamma vinyl-GABA following a nicotine or cocaine challenge: a PET/microdialysis study. Life sciences, 2000, Feb-18, Volume: 66, Issue:13 Topics: Animals; Cocaine; Dopamine; Male; Microdialysis; Nicotine; Nucleus Accumbens; Papio; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tomography, Emission-Computed; Vigabatrin	2000
GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine. European journal of pharmacology, 2001, Mar-02, Volume: 414, Issue:2-3 Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Conditioning, Psychological; Cues; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vigabatrin	2001
The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat. Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:2 Topics: Alcohol Drinking; Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Rats; Rats, Wistar; Self Administration; Vigabatrin	2001
Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats. Synapse (New York, N.Y.), 2002, Dec-15, Volume: 46, Issue:4 Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Addictive; Cocaine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Vigabatrin	2002
Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine. Psychopharmacology, 2003, Volume: 168, Issue:3 Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Time Factors; Vigabatrin	2003
Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:12 Topics: Analysis of Variance; Animals; Anticonvulsants; Antipsychotic Agents; Carbon Isotopes; Cerebellum; Cocaine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Papio; Phencyclidine; Raclopride; Time Factors; Tomography, Emission-Computed; Vigabatrin	2003
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization. European journal of pharmacology, 2006, Jul-17, Volume: 541, Issue:3 Topics: Amines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Male; Motor Activity; Nipecotic Acids; Rats; Rats, Wistar; Tiagabine; Vigabatrin	2006
Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats. Psychopharmacology, 2007, Volume: 192, Issue:1 Topics: Amines; Animals; Behavior, Animal; Cocaine; Cyclohexanecarboxylic Acids; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Tiagabine; Vigabatrin	2007
Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism. Drug and alcohol dependence, 2008, Oct-01, Volume: 97, Issue:3 Topics: Animals; Behavior, Addictive; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Exploratory Behavior; Extinction, Psychological; GABA Agents; Male; Nucleus Accumbens; Rats; Rats, Long-Evans; Reward; Self Administration; Vigabatrin	2008