cocaine has been researched along with vanoxerine in 190 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.63) | 18.7374 |
| 1990's | 105 (55.26) | 18.2507 |
| 2000's | 67 (35.26) | 29.6817 |
| 2010's | 12 (6.32) | 24.3611 |
| 2020's | 1 (0.53) | 2.80 |
| Authors | Studies |
|---|---|
| Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH | 1 |
| Allen, AC; George, C; Izenwasser, S; Katz, JL; Kline, RH; Newman, AH | 1 |
| Allen, AC; Izenwasser, S; Katz, JL; Newman, AH | 1 |
| Goodman, MM; Kabalka, GW; Kung, HF; Kung, MP; Switzer, R | 1 |
| Baldessarini, RJ; Gao, Y; Kula, NS; Milius, RA; Neumeyer, JL; Tamagnan, G; Wang, S | 1 |
| de Costa, BR; Dersch, CM; Glowa, JR; Matecka, D; Partilla, JS; Pert, A; Radesca, L; Rice, KC; Rothman, RB; Wojnicki, FH | 1 |
| Bowen, WD; Husbands, SM; Izenwasser, S; Katz, JL; Kopajtic, T; Newman, AH; Vilner, BJ | 1 |
| Beardsley, PM; Dutta, AK; Fei, XS; Newman, JL; Reith, ME | 1 |
| Cao, J; Husbands, SM; Katz, JL; Kopajtic, T; Newman, AH | 1 |
| Beardsley, PM; Cook, CD; Davis, MC; Dutta, AK; Fei, XS; Reith, ME | 1 |
| Bradley, AL; Izenwasser, S; Klein-Stevens, C; Trudell, ML; Wade, D; Zhu, N | 1 |
| Beardsley, PM; Cook, C; Davis, M; Dutta, AK; George, C; Ghorai, SK; Reith, ME; Venkataraman, SK | 1 |
| Dutta, AK; Reith, ME; Zhang, S | 1 |
| Dutta, AK; George, C; Ghorai, SK; Kolhatkar, RB; Reith, ME | 1 |
| Bowen, WD; Cao, J; George, C; Husbands, SM; Katz, JL; Kopajtic, T; Kulkarni, SS; Newman, AH; Williams, W | 1 |
| Budygin, EA; Byrd, GD; Childers, SR; Harp, JJ; Jones, SR; Lapa, AA; Lapa, GB | 1 |
| Chang, LT; Dersch, CM; Hsin, LW; Jacobson, AE; Rice, KC; Rothman, RB | 1 |
| Bakare, OM; Bi, GH; Bonifazi, A; Burzynski, C; Cao, J; Ellenberger, MP; He, Y; Kopajtic, T; Loland, CJ; Newman, AH; Rais, R; Slack, RD; Slusher, BS; Xi, ZX; Yano, H | 1 |
| Herkenham, M; Hurd, YL | 1 |
| Bergman, J; Madras, BK; Rosenzweig-Lipson, S; Spealman, RD | 1 |
| Kuribara, H; Tadokoro, S; Uchihashi, Y | 1 |
| Akunne, HC; de Costa, BR; Jacobson, AE; Rice, KC; Rothman, RB | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Johnson, M; Midgley, L | 1 |
| Carroll, FI; De Costa, BR; Grieg, N; Kim, A; Pert, A; Rice, KC; Rothman, RB | 1 |
| De Montis, G; Devoto, P; Tagliamonte, A | 1 |
| Borowsky, B; Kuhn, CM | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Johnson, M | 1 |
| Byrd, LD; Howell, LL | 1 |
| Melia, KF; Spealman, RD | 1 |
| Brownstein, MJ; Chen, C; Hoffman, BJ; Mezey, E; Usdin, TB | 1 |
| Cox, BM; Izenwasser, S; Jacocks, HM; Werling, LL | 1 |
| Akunne, H; deCosta, BR; Grieg, N; Mele, A; Pert, A; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Callahan, PM; Cunningham, KA | 1 |
| Baldo, BA; Kelley, AE | 1 |
| Akunne, HC; de Costa, BR; Greig, N; Mele, A; Pert, A; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Gale, K; Meloni, R | 1 |
| Kuhar, MJ; Pögün, S; Scheffel, U | 1 |
| Arroyo, J; Berger, P; Elsworth, JD; Roth, RH | 1 |
| Bush, L; Gibb, JW; Hanson, GR; Johnson, M; Smiley, PL | 1 |
| Bannon, MJ; Dragovic, LJ; Kapatos, G; Shibata, K; Xue, CH | 1 |
| Cox, BM; Izenwasser, S; Werling, LL | 1 |
| Garrett, MC; Soares-da-Silva, P | 1 |
| Anthony, EW; Kleven, MS; Woolverton, WL | 1 |
| Bergman, J; Johnson, SE; Madras, BK; Spealman, RD | 1 |
| Andersen, PH | 1 |
| Kruk, ZL; Millar, J; Stamford, JA | 1 |
| Akunne, H; Greig, N; Mele, A; Pert, A; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Debler, EA; Hashim, A; Lajtha, A; Sershen, H | 1 |
| Spealman, RD | 1 |
| Edwards, MA; Kantak, KM; Spealman, RD | 1 |
| Tella, SR | 2 |
| al-Tikriti, MS; Baldwin, RM; Laruelle, M; Malison, RT; Neumeyer, JL; Sybirska, EH; Wisniewski, G; Zea-Ponce, Y; Zimmermann, RC; Zoghbi, SS | 1 |
| Essman, WD; Lucki, I; Singh, A | 1 |
| Kling-Petersen, T; Ljung, E; Svensson, K | 1 |
| Callaway, CW; Geyer, MA; Paulus, MP | 1 |
| Coffey, LL; Reith, ME; Xu, C | 1 |
| Goldberg, SR; Tella, SR | 2 |
| Brinjak, R; Chrapusta, SJ; Hitri, A; Karoum, F; Wyatt, RJ | 1 |
| Meiergerd, SM; Schenk, JO | 1 |
| Coen, KM; Corrigall, WA | 1 |
| Kelley, AE; Maldonado-Irizarry, CS; Stellar, JR | 1 |
| Baumann, MH; Char, GU; De Costa, BR; Rice, KC; Rothman, RB | 1 |
| Masserano, JM; Venable, D; Wyatt, RJ | 1 |
| Dutta, AK; Madras, BK; Meltzer, PC; Reith, ME | 1 |
| Erwin, VG; Jones, BC; Womer, DE | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Cheng, CH; Costall, B; Naylor, RJ; Rudd, JA | 1 |
| Chuang, EJ; Draisci, G; Gu, J; Hoo, Y; Iadarola, MJ; Silverthorn, M; Yeung, CL | 1 |
| Henry, DJ; Hu, XT; White, FJ | 1 |
| Berger, P; Elsworth, JD; Roth, RH; Taylor, JR | 1 |
| Skjoldager, P; Winger, G; Woods, JH | 1 |
| Bergmann, JS; Gifford, AN; Johnson, KM | 1 |
| Butler, T; Dobbie, JW; Duffield, R; Hjelle, JT; Ho, AK; Miller-Hjelle, MA; Reith, M; Steidley, KR | 1 |
| Chen, NH; Coffey, LL; Reith, ME; Xu, C | 1 |
| Dow-Edwards, DL; Frick, GS | 1 |
| Sivam, SP | 1 |
| Glowa, JR; Wojnicki, FH | 1 |
| Glowa, JR; Koetzner, L; Riley, AL | 1 |
| Brockington, A; Carrol, FI; Elmer, GI; Goldberg, SR; Gorelick, DA; Matecka, D; Rice, KC; Rothman, RB | 1 |
| Andrews, AM; Cadet, JL; Goldberg, SR; Ladenheim, B; Tella, SR | 1 |
| Bekavac, I; Gould, EM; Waterhouse, BD | 1 |
| Fantegrossi, WE; Glowa, JR; Lewis, DB; Matecka, D; Rice, KC; Rothman, RB | 1 |
| Koob, GF; Parsons, LH; Weiss, F | 1 |
| Coffey, LL; Dutta, AK; Reith, ME | 2 |
| Dersch, CM; DeVries, AC; Glowa, JR; Lewis, D; Matecka, D; Pert, A; Rice, KC; Rothman, RB; Wojnicki, FH | 1 |
| Carroll, FI; Holmquist, CR; Kepler, JA; Kuhar, MJ; Saindane, AM; Scheffel, U; Taylor, GF; Zhan, Y | 1 |
| Francis, R; Kuhn, C | 1 |
| Glowa, JR; Matecka, D; Rice, KC; Rothman, RB | 1 |
| Glowa, JR | 1 |
| Gorelick, DA | 1 |
| Gan, Q; Knuepfer, MM | 1 |
| Bender, M; Drago, J; Rivkees, SA | 1 |
| Izenwasser, S; Kunko, PM; Loeloff, RJ | 1 |
| Dannals, RF; Liu, X; Mochizuki, T; Musachio, JL; Scheffel, U; Villemagne, VL; Wagner, HN | 1 |
| Di Chiara, G; Frau, R; Pontieri, FE; Tanda, G | 1 |
| Geter-Douglass, B; Tirelli, E; Witkin, JM | 1 |
| Serrão, MP; Soares-Da-Silva, P; Vieira-Coelho, MA | 1 |
| Gong, W; Justice, JB; Neill, DB | 1 |
| Agoston, GE; Newman, AH | 1 |
| Dutta, AK; Reith, ME; Xu, C | 1 |
| Holtzman, SG; Waddell, AB | 1 |
| Higgins, GA; Varty, GB | 1 |
| Misawa, M; Mori, T; Onodera, K; Suzuki, T; Tsuji, M | 1 |
| Berger, R; Brust, P; Hoepping, A; Johannsen, B; Leibnitz, P; Machill, S; Scheller, D; Spies, H | 1 |
| Steketee, JD | 1 |
| Booij, J; de Bruin, K; Janssen, AG; Knol, RJ; Reneman, L; van Royen, EA | 1 |
| Glowa, JR; Rice, KC; Rothman, RB; Wojnicki, FH | 1 |
| Gasior, M; Goldberg, SR; Jaszyna, M; Shoaib, M; Yasar, S | 1 |
| Dannals, RF; Matecka, D; Rice, KC; Rothman, RB; Villemagne, VL; Wong, DF; Yokoi, F | 1 |
| Dow-Edwards, D; Shi, X; Yin, R | 1 |
| Carroll, FI; Damaj, MI; Martin, BR; Slemmer, JE | 1 |
| Miller, DK; Nation, JR | 1 |
| Binnekade, R; De Vries, TJ; Schoffelmeer, AN; Vanderschuren, LJ | 1 |
| Grech, DM; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Carroll, FI; French, D; Izenwasser, S; Kunko, PM | 1 |
| Besnard, JC; Chalon, S; Emond, P; Garreau, L; Guilloteau, D; Vilar, MP; Zimmer, L | 1 |
| Harada, N; Kakiuchi, T; Nakanishi, S; Nishiyama, S; Ohba, H; Sato, K; Tsukada, H | 1 |
| Baldessarini, RJ; Fisser, R; Kula, NS; Neumeyer, JL; Tarazi, FI; Trometer, J; Wang, S | 1 |
| Besnard, JC; Bottlaender, M; Chalon, S; Coulon, C; Emond, P; Frangin, Y; Fuseau, C; Guenther, I; Guilloteau, D; Helfenbein, J; Loc'h, C; Maziere, B; Ottaviani, M | 1 |
| Carrol, FI; Czoty, PW; Howell, LL; Kuhar, MJ | 1 |
| Harada, N; Kakiuchi, T; Nishiyama, S; Ohba, H; Tsukada, H | 2 |
| Czoty, PW; Howell, LL; Justice, JB | 1 |
| Kaneda, S; Kato, B; Kawai, Y; Matsushita, H; Nishi, M; Noritake, K; Sorimachi, Y; Takeuchi, Y; Ueda, S; Yang, Y; Yasuhara, M; Yoshimoto, K | 1 |
| Brezausek, C; Moore, JF; Percy, AK; Theibert, A; Zachor, DA | 1 |
| Wirtshafter, D | 1 |
| Davidson, C; Douglas, SB; Ellinwood, EH; Lee, TH | 1 |
| Baniecki, M; Collins, HA; Hanson, RN; Hinerth, MA; Waszczak, BL | 1 |
| Carboni, E; Di Chiara, G; Rolando, MT; Silvagni, A | 1 |
| Brodde, OE; Leineweber, K; Seyfarth, T | 1 |
| Hashim, A; Lajtha, A; Sershen, H | 1 |
| Glowa, JR; Lewis, DB; Rice, KC; Stafford, D | 1 |
| Glowa, JR; LeSage, MG; Rice, KC; Stafford, D | 1 |
| Dutta, AK; Madras, BK; Reith, ME | 1 |
| Cox, BM; D'Addario, C; Ferri, S; Izenwasser, S; Romualdi, P | 1 |
| Carboni, E; Di Chiara, G; Giros, B; Nosten-Bertrand, M; Spielewoy, C; Vacca, C | 1 |
| Agoston, GE; Hecht, GS; Katz, JL; Newman, AH; Woolverton, WL | 1 |
| Baek, D; Bergstrom, DA; Freeman, LE; Ruskin, DN; Walters, JR | 1 |
| Holtzman, SG | 1 |
| Busidan, Y; Dow-Edwards, DL | 1 |
| Platt, DM; Rowlett, JK; Spealman, RD | 2 |
| Garland, T; Girard, I; Hosack, GR; Kelley, AE; Mitchell, GS; Rhodes, JS | 1 |
| Cornish, JL; Kalivas, PW | 1 |
| Brockington, A; Hope, BT; Morón, JA; Rocha, BA; Wise, RA | 1 |
| Schenk, S | 1 |
| Hanania, T; Zahniser, NR | 1 |
| Carmona, GN; Schindler, CW | 1 |
| Cadet, JL; Carroll, FI; Collins, SL; Izenwasser, S; Kunko, PM; Ladenheim, B | 1 |
| Fukumoto, D; Harada, N; Kakiuchi, T; Nishiyama, S; Satoh, K; Tsukada, H | 1 |
| Davidson, C; Ellinwood, EH; King, GR; Lee, TH; Yu, GZ | 1 |
| Dersch, CM; Horel, R; Hsin, LW; Jacobson, AE; Prisinzano, T; Rice, KC; Rothman, RB; Wilkerson, CR | 1 |
| Janak, PH; Mcgeehan, AJ; Olive, MF | 1 |
| Gasior, M; Kaminski, R; Witkin, JM | 1 |
| Bergman, J; Czoty, PW; Makriyannis, A | 1 |
| Chen, N; Reith, ME; Zhen, J | 1 |
| Hagino, Y; Hall, FS; Ikeda, K; Kobayashi, H; Lesch, KP; Murphy, DL; Shen, HW; Shinohara-Tanaka, K; Sora, I; Uhl, GR; Yamamoto, H; Yamamoto, T | 1 |
| Steketee, JD; Williams, JM | 1 |
| Candeletti, S; D'Addario, C; Di Benedetto, M; Feliciani, D; Izenwasser, S; Romualdi, P | 1 |
| Barrett, AC; Caine, SB; Dohrmann, JM; Miller, JR | 1 |
| Chen, N; Dutta, AK; Maiti, S; Reith, ME; Zhen, J | 1 |
| Dutta, AK; Reith, ME; Wang, LC | 1 |
| Boos, TL; Calhoun, WJ; Dersch, CM; Greiner, E; Jacobson, AE; Nightingale, B; Rice, KC; Rothman, RB | 1 |
| Desai, RI; French, D; Katz, JL; Kopajtic, TA; Newman, AH | 1 |
| Bronius, PF; Brueggeman, RJ; Schoffelmeer, AN; van Gaalen, MM; Vanderschuren, LJ | 1 |
| Bevins, RA; Linkugel, JD; Reichel, CM | 1 |
| Fagerholm, V; Grönroos, T; Haaparanta, M; Koivula, T; Lipponen, T; Marjamäki, P; Perhola, O; Solin, O; Vepsäläinen, J | 1 |
| España, RA; Jones, SR; Roberts, DC | 1 |
| Aksenov, MY; Aksenova, MV; Booze, RM; Mactutus, CF; Silvers, JM | 1 |
| Cao, J; Katz, JL; Kopajtic, T; Newman, AH | 1 |
| Chen, N; Dutta, AK; Kharkar, P; Mishra, M; Reith, ME; Schmitt, KC; Zhen, J | 1 |
| Hall, FS; Jones, JD; Rice, K; Riley, AL; Uhl, GR | 1 |
| Cain, SM; Dewar, D; Duncan, R; Patterson, J; Pimlott, S; Ruest, T; Sills, GJ | 1 |
| Bergman, J; Desai, R; Desai, RI; Martin, J; Paronis, CA | 1 |
| Aragona, BJ; Carelli, RM; Kile, BM; Park, J; Wightman, RM | 1 |
| Donovan, DM; Katz, JL; Kopajtic, TA; Liu, Y; Newman, AH; Surratt, CK | 1 |
| Briscione, MA; Rice, KC; Riley, AL; Serafine, KM | 1 |
| Conover, K; Cossette, MP; Hernandez, G; Shizgal, P; Trujillo-Pisanty, I | 1 |
| Palmiter, RD; Whiddon, BB | 1 |
| Achterberg, EJ; Schoffelmeer, AN; Schrama, L; Siviy, SM; Trezza, V; Vanderschuren, LJ | 1 |
| Chang, SC; Folsom, RJ; Jang, EY; Kim, HY; Kim, KJ; Kim, SH; Lee, BH; Ryu, YH; Schilaty, ND; Steffensen, SC; Yang, CH; Yeo, MJ | 1 |
| Huang, X; Midde, NM; Quizon, PM; Sun, WL; Yuan, Y; Zhan, CG; Zhu, J | 1 |
| Aalderink, M; Achterberg, EJ; Driel, NV; Houwing, DJ; Servadio, M; Trezza, V; van Kerkhof, LW; van Swieten, MM; Vanderschuren, LJ | 1 |
| Desai, RI; Katz, JL; Slezak, JM | 1 |
| Budygin, EA; Costa, F; Gerasimova, EV; Grinevich, VP; Kalueff, AV; Kolesnikova, TO; Maslov, GO; Viktorova, YA; Zabegalov, KN | 1 |
| Grundt, P; Katz, JL; Kopajtic, T; Kulkarni, SS; Newman, AH | 1 |
| Beardsley, PM; Cook, CD; Deschamps, J; Dutta, AK; Ghorai, SK; Kolhatkar, R; Reith, ME | 1 |
3 review(s) available for cocaine and vanoxerine
| Article | Year |
|---|---|
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 1992 |
Dopamine, serotonin and tachykinin in self-injurious behavior.
Topics: Animals; Cocaine; Dopamine; Humans; Lesch-Nyhan Syndrome; Piperazines; Rats; Self-Injurious Behavior; Serotonin; Tachykinins | 1996 |
Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter.
Topics: Benztropine; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Stereoisomerism; Structure-Activity Relationship; Substance-Related Disorders | 1998 |
1 trial(s) available for cocaine and vanoxerine
| Article | Year |
|---|---|
Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior.
Topics: Animals; Animals, Outbred Strains; Breeding; Cocaine; Crosses, Genetic; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Fluoxetine; Hyperkinesis; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Piperazines | 2001 |
186 other study(ies) available for cocaine and vanoxerine
| Article | Year |
|---|---|
Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tropanes | 1995 |
Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.
Topics: Animals; Behavior, Animal; Benztropine; Cocaine; Dopamine Antagonists; Mice; Rats; Structure-Activity Relationship; Tropanes | 1994 |
Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tropanes | 1994 |
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.
Topics: Animals; Binding Sites; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Probes; Nerve Tissue Proteins; Prosencephalon; Radioligand Assay; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
Topics: Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Conformation; Molecular Structure; Nerve Tissue Proteins; Piperazines; Rats; Receptors, Drug; Serotonin; Substance-Related Disorders | 1996 |
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Topics: Aniline Compounds; Animals; Brain; Carbazoles; Carrier Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 1999 |
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
Topics: Animals; Carrier Proteins; Cocaine; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 2001 |
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.
Topics: Animals; Carbazoles; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Probes; Nerve Tissue Proteins; Piperazines; Rats | 2001 |
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Piperidines; Radioligand Assay; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 2002 |
Synthesis and dopamine transporter binding affinities of 3alpha-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes.
Topics: Bridged Bicyclo Compounds; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Octanes; Protein Binding; Structure-Activity Relationship | 2002 |
High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.
Topics: Animals; Benzhydryl Compounds; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Crystallography, X-Ray; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Molecular Structure; Motor Activity; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioligand Assay; Rats; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters | 2003 |
Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperidines; Pyrans; Rats; Stereoisomerism; Structure-Activity Relationship | 2003 |
Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-
Topics: Animals; Binding, Competitive; Biogenic Monoamines; Biological Transport; Brain; Carrier Proteins; Crystallography, X-Ray; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Conformation; Nerve Tissue Proteins; Nitriles; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Piperidines; Radioligand Assay; Rats; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters | 2003 |
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.
Topics: Animals; Binding, Competitive; Brain; Cocaine-Related Disorders; Crystallography, X-Ray; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Rats; Receptors, sigma; Structure-Activity Relationship | 2003 |
The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines.
Topics: Dopamine Plasma Membrane Transport Proteins; Inhibitory Concentration 50; Molecular Structure; Piperidines; Structure-Activity Relationship | 2005 |
Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, m
Topics: Dopamine Plasma Membrane Transport Proteins; Piperazines; Radioligand Assay; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2008 |
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Topics: Animals; Benzhydryl Compounds; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Modafinil; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2016 |
Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Neuropeptides; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1992 |
Stereoselective behavioral effects of Lu 19-005 in monkeys: relation to binding at cocaine recognition sites.
Topics: Animals; Behavior, Animal; Binding, Competitive; Carrier Proteins; Cocaine; Conditioning, Operant; Dopamine; Indans; Ligands; Male; Piperazines; Receptors, Drug; Reinforcement Schedule; Saimiri; Stereoisomerism | 1992 |
Assessment of the ambulation-increasing effect of ketamine by coadministration with central-acting drugs in mice.
Topics: alpha-Methyltyrosine; Animals; Caffeine; Central Nervous System Agents; Central Nervous System Depressants; Ceruletide; Cocaine; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Methamphetamine; Methyltyrosines; Mice; Morphine; Motor Activity; Neurotransmitter Uptake Inhibitors; Nimodipine; Piperazines; Scopolamine | 1992 |
[3H] cocaine labels a binding site associated with the serotonin transporter in guinea pig brain: allosteric modulation by paroxetine.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Carrier Proteins; Cell Membrane; Cocaine; Guinea Pigs; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Piperazines; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes; Tritium | 1992 |
MK-801 blocks the changes in neurotensin concentrations induced by methamphetamine, 3,4-methylenedioxymethamphetamine, cocaine, and GBR 12909.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Cocaine; Dizocilpine Maleate; Male; Methamphetamine; Neurotensin; Piperazines; Rats; Rats, Sprague-Dawley | 1992 |
Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Nomifensine; Phencyclidine; Piperazines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1992 |
Failure by tricyclic antidepressants to affect the increase of dopamine extracellular concentrations produced by haloperidol in the caudate and accumbens nuclei of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Antidepressive Agents, Tricyclic; Caudate Nucleus; Cocaine; Dopamine; Drug Interactions; Haloperidol; Imipramine; Male; Nucleus Accumbens; Piperazines; Rats; Rats, Inbred Strains | 1992 |
Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation.
Topics: Adrenocorticotropic Hormone; Animals; Biogenic Monoamines; Cocaine; Corticosterone; Dopamine; Dopamine Antagonists; Haloperidol; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Ketanserin; Male; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Piperazines; Pituitary-Adrenal System; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stimulation, Chemical; Time Factors | 1991 |
Role of N-methyl-D-aspartate (NMDA) receptors in the response of extrapyramidal neurotensin and dynorphin A systems to cocaine and GBR 12909.
Topics: Animals; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dynorphins; Male; Neurotensin; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1991 |
Characterization of the effects of cocaine and GBR 12909, a dopamine uptake inhibitor, on behavior in the squirrel monkey.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Cocaine; Dopamine Agents; Drug Interactions; Ergolines; Injections, Intravenous; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Quinpirole; Saimiri; Self Administration | 1991 |
Pharmacological characterization of the discriminative-stimulus effects of GBR 12909.
Topics: Animals; Cocaine; Discrimination Learning; Dopamine Agents; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Receptors, Dopamine; Saimiri; Salicylamides | 1991 |
Cloning of the cocaine-sensitive bovine dopamine transporter.
Topics: Amino Acid Sequence; Animals; Antisense Elements (Genetics); Base Sequence; Carrier Proteins; Cattle; Cell Line; Cloning, Molecular; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Gene Library; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nucleic Acid Hybridization; Piperazines; RNA; RNA Probes; Sequence Homology, Nucleic Acid; Substantia Nigra; Transfection; Tyrosine 3-Monooxygenase | 1991 |
Comparison of dopamine uptake and release in vitro in sheep and rat striatum.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Female; Fluoxetine; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sheep | 1991 |
Preliminary evidence that the high affinity dopamine reuptake inhibitor, GBR12909, antagonizes the ability of cocaine to elevate extracellular levels of dopamine.
Topics: Animals; Caudate Nucleus; Cocaine; Dopamine; In Vitro Techniques; Membranes; Neurotransmitter Uptake Inhibitors; Piperazines; Rats | 1990 |
Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat.
Topics: Animals; Cocaine; Desipramine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluoxetine; Male; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains | 1991 |
Cross-sensitization between cocaine and GBR 12909, a dopamine uptake inhibitor.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains; Reference Values | 1991 |
GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine.
Topics: Animals; Carrier Proteins; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dialysis; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electrochemistry; Extracellular Space; Kinetics; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains | 1991 |
Cocaine-induced turning behavior in rats with 6-hydroxydopamine lesions: effect of transplants of fetal substantia nigra.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Diseases; Brain Tissue Transplantation; Cocaine; Dopamine; Fetal Tissue Transplantation; Fluoxetine; Imipramine; Male; Neural Pathways; Neurotransmitter Uptake Inhibitors; Nomifensine; Oxidopamine; Piperazines; Rats; Rats, Inbred Strains; Substantia Nigra | 1991 |
Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909.
Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Injections, Intravenous; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Piperazines; Radioimmunoassay; Receptors, Drug | 1991 |
Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens.
Topics: Animals; Binding, Competitive; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Kinetics; Male; Membrane Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Piperazines; Rats; Rats, Inbred Strains; Septal Nuclei | 1990 |
Effects of cocaine on extrapyramidal and limbic dynorphin systems.
Topics: Animals; Benzazepines; Cocaine; Dopamine Antagonists; Dynorphins; Extrapyramidal Tracts; Limbic System; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1990 |
Expression of a human cocaine-sensitive dopamine transporter in Xenopus laevis oocytes.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Injections; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Oocytes; Piperazines; RNA, Messenger; Substantia Nigra; Xenopus laevis | 1990 |
Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluoxetine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Nalidixic Acid; Naphthyridines; Neurotransmitter Uptake Inhibitors; Norepinephrine; Nucleus Accumbens; Olfactory Bulb; Piperazines; Rats; Rats, Inbred Strains | 1990 |
Overflow of endogenous dopamine and 3,4-dihydroxyphenylacetic acid from tissues of the rat brain, elicited by electrical stimulation, depolarization by potassium and activation of carrier-mediated release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Neurons; Neurotransmitter Uptake Inhibitors; Piperazines; Potassium; Rats; Rats, Inbred Strains | 1990 |
Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys.
Topics: Animals; Benzazepines; Cocaine; Dextroamphetamine; Discrimination Learning; Female; Haloperidol; Macaca mulatta; Male; Piperazines; Receptors, Dopamine | 1990 |
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
Topics: Animals; Bupropion; Cocaine; Dopamine; Male; Mazindol; Methylphenidate; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Propiophenones; Saimiri; Self Administration | 1989 |
The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.
Topics: Animals; Cocaine; Dopamine; In Vitro Techniques; Kinetics; Male; Mazindol; Methylphenidate; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1989 |
Dissociation of the actions of uptake blockers upon dopamine overflow and uptake in the rat nucleus accumbens: in vivo voltammetric data.
Topics: Animals; Benztropine; Bupropion; Cocaine; Dopamine; Electric Stimulation; Electrochemistry; Levodopa; Male; Microelectrodes; Neurotransmitter Uptake Inhibitors; Nomifensine; Nucleus Accumbens; Piperazines; Propiophenones; Rats; Rats, Inbred Strains; Septal Nuclei | 1989 |
Tight binding dopamine reuptake inhibitors as cocaine antagonists. A strategy for drug development.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Extracellular Space; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Inbred Strains | 1989 |
Ascorbic acid and striatal transport of [3H] 1-methyl-4-phenylpyridine (MPP+) and [3H] dopamine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Ascorbic Acid; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Kinetics; Mazindol; Mice; Nicotine; Piperazines; Pyridines; Synaptosomes | 1988 |
Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Citalopram; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Narcotics; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Receptors, Adrenergic, alpha; Saimiri; Selective Serotonin Reuptake Inhibitors | 1995 |
Effects of N-methyl-D-aspartate antagonists in rats discriminating different doses of cocaine: comparison with direct and indirect dopamine agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cocaine; Discrimination Learning; Dopamine Agonists; Male; N-Methylaspartate; Oxazines; Piperazines; Rats; Rats, Wistar | 1995 |
Effects of monoamine reuptake inhibitors on cocaine self-administration in rats.
Topics: Animals; Biogenic Monoamines; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intravenous; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Reward; Self Administration | 1995 |
SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates.
Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Chlorocebus aethiops; Citalopram; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Indans; Iodine Radioisotopes; Levodopa; Ligands; Maprotiline; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Papio; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Tomography, Emission-Computed, Single-Photon | 1993 |
Serotonergic properties of cocaine: effects on a 5-HT2 receptor-mediated behavior and on extracellular concentrations of serotonin and dopamine.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electrochemistry; Extracellular Space; Ketanserin; Male; Microdialysis; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission | 1994 |
The preferential dopamine autoreceptor antagonist (+)-UH232 antagonizes the positive reinforcing effects of cocaine and d-amphetamine in the ICSS paradigm.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Cocaine; Dextroamphetamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrodes; Haloperidol; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Stimulation | 1994 |
Quantitative assessment of the microstructure of rat behavior: II. Distinctive effects of dopamine releasers and uptake inhibitors.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dextroamphetamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Motor Activity; Nomifensine; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1993 |
Translocation of dopamine and binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations. Inhibition by various blockers.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Synaptosomes; Tritium | 1995 |
Monoamine uptake inhibitors alter cocaine pharmacokinetics.
Topics: Animals; Biotransformation; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Interactions; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley | 1993 |
Regional effects of amphetamine, cocaine, nomifensine and GBR 12909 on the dynamics of dopamine release and metabolism in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Male; Methyltyrosines; Nomifensine; Piperazines; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 1994 |
Kinetic evaluation of the commonality between the site(s) of action of cocaine and some other structurally similar and dissimilar inhibitors of the striatal transporter for dopamine.
Topics: Animals; Benztropine; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Male; Mazindol; Models, Biological; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Rats; Rats, Sprague-Dawley | 1994 |
Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus.
Topics: Animals; Benzazepines; Cocaine; Cues; Discrimination Learning; Discrimination, Psychological; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Stimulus; Male; Neurotransmitter Uptake Inhibitors; Nicotine; Piperazines; Rats; Receptors, Dopamine D1; Reinforcement Schedule; Spiperone | 1994 |
Effects of cocaine and GBR-12909 on brain stimulation reward.
Topics: Animals; Brain; Cocaine; Dose-Response Relationship, Drug; Electrodes, Implanted; Male; Medial Forebrain Bundle; Motor Activity; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation | 1994 |
GBR12909 attenuates cocaine-induced activation of mesolimbic dopamine neurons in the rat.
Topics: Amphetamine; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley | 1994 |
Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats.
Topics: Animals; Brain; Cerebral Cortex; Cocaine; Corpus Striatum; Depression, Chemical; Dopamine; Drug Interactions; Frontal Lobe; Male; Methamphetamine; Motor Activity; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors; Tritium | 1994 |
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.
Topics: Animals; Carrier Proteins; Caudate Nucleus; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Protein Binding; Putamen; Serotonin; Serotonin Plasma Membrane Transport Proteins | 1994 |
Characterization of dopamine transporter and locomotor effects of cocaine, GBR 12909, epidepride, and SCH 23390 in C57BL and DBA mice.
Topics: Animals; Benzamides; Benzazepines; Binding, Competitive; Brain; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Female; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Piperazines; Pyrrolidines; Species Specificity | 1994 |
Discriminative stimulus properties of cocaine in the rat using a two-choice discrete-trial avoidance paradigm.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Avoidance Learning; Benzazepines; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Agents; Dose-Response Relationship, Drug; Electroshock; Ergolines; Haloperidol; Male; Methamphetamine; Neurotransmitter Uptake Inhibitors; Piperazines; Quinpirole; Rats; Sulpiride | 1993 |
The effect of 5-HT receptor ligands on the uptake of [3H]5-hydroxytryptamine into rat cortical synaptosomes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Cocaine; Desipramine; Female; Fluoxetine; In Vitro Techniques; Indoles; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptosomes; Tropisetron | 1993 |
Induction and suppression of proto-oncogenes in rat striatum after single or multiple treatments with cocaine or GBR-12909.
Topics: Amino Acid Sequence; Animals; Benzazepines; Blotting, Northern; Blotting, Western; Cocaine; Corpus Striatum; Gene Expression; Genes, fos; Immunohistochemistry; Male; Molecular Sequence Data; Neurotransmitter Uptake Inhibitors; Piperazines; Proto-Oncogenes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulpiride; Suppression, Genetic | 1993 |
Electrophysiological effects of cocaine in the rat nucleus accumbens: microiontophoretic studies.
Topics: alpha-Methyltyrosine; Animals; Cocaine; Dopamine; Fenclonine; Fluoxetine; Iontophoresis; Male; Methyltyrosines; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Serotonin | 1993 |
Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum.
Topics: Analysis of Variance; Animals; Cocaine; Corpus Striatum; Dopamine; Drug Resistance; Male; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Ouabain; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Temperature | 1993 |
Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys.
Topics: Animals; Arousal; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Motivation; Motor Activity; Neurotransmitter Uptake Inhibitors; Piperazines; Self Administration; Substance-Related Disorders | 1993 |
GBR 12909 fails to antagonize cocaine-induced elevation of dopamine in striatal slices.
Topics: Animals; Cocaine; Corpus Striatum; Culture Techniques; Dopamine; Female; Male; Mazindol; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Synaptosomes | 1993 |
Multiple drug classes and hyperosmolarity alter binding of muscarinic drugs to mesothelial cells in vitro.
Topics: Animals; Atropine; Cells, Cultured; Cocaine; Cycloheximide; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Epithelium; Mannitol; Muscarinic Antagonists; N-Methylscopolamine; Osmolar Concentration; Parasympatholytics; Peritoneum; Piperazines; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Sodium Chloride | 1995 |
[3H]WIN 35,428 [2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane] binding to rat brain membranes. Comparing dopamine cell body areas with nerve terminal regions.
Topics: Animals; Brain; Cell Membrane; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Mesencephalon; Nerve Endings; Nucleus Accumbens; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium | 1996 |
The effects of cocaine on cerebral metabolic function in periweanling rats: the roles of serotonergic and dopaminergic uptake blockade.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Male; Pharmaceutical Vehicles; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Weaning | 1995 |
Effects of drug history on the acquisition of responding maintained by GBR 12909 in rhesus monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Macaca mulatta; Piperazines; Reinforcement, Psychology; Self Administration; Time Factors | 1996 |
Possible novel pharmacodynamic action of cocaine: cardiovascular and behavioral evidence.
Topics: Animals; Behavior, Animal; Blood Pressure; Catecholamines; Chlorisondamine; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ganglionic Blockers; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley | 1996 |
Discriminative stimulus effects of dopaminergic agents in rhesus monkeys.
Topics: Animals; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dopamine Agents; Dose-Response Relationship, Drug; Macaca mulatta; Male; Narcotics; Phentermine; Piperazines; Self Administration | 1996 |
Cocaine cross-sensitization to dopamine uptake inhibitors: unique effects of GBR12909.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mazindol; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1996 |
Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system.
Topics: Adaptation, Physiological; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Injections, Intravenous; Limbic System; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Water | 1996 |
Monoaminergic substrates underlying cocaine-induced enhancement of somatosensory-evoked discharges in rat barrel field cortical neurons.
Topics: Animals; Cocaine; Desipramine; Dopamine; Fluoxetine; Male; Norepinephrine; Piperazines; Rats; Serotonin; Somatosensory Cortex | 1996 |
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.
Topics: Animals; Behavior, Animal; Cocaine; Decanoates; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Molecular Structure; Piperazines; Substance-Related Disorders | 1996 |
Serotonin1b receptor stimulation enhances dopamine-mediated reinforcement.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Narcotics; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration; Serotonin Receptor Agonists | 1996 |
Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.
Topics: Animals; Carrier Proteins; Citalopram; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats | 1997 |
Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Feeding Behavior; Ligands; Macaca mulatta; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Motor Activity; Nerve Tissue Proteins; Pentazocine; Piperazines; Rats; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 1997 |
RTI-352: a 3 alpha analogue of RTI-55 as an in vivo dopamine transporter binding ligand.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Desipramine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Piperazines; Tritium | 1997 |
Gender difference in cocaine-induced HPA axis activation.
Topics: Adrenocorticotropic Hormone; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Fluoxetine; Hypothalamo-Hypophyseal System; Male; Neurotransmitter Uptake Inhibitors; Orchiectomy; Ovariectomy; Piperazines; Pituitary-Adrenal System; Rats; Sex Characteristics; Time Factors | 1997 |
Phentermine/fenfluramine decreases cocaine self-administration in rhesus monkeys.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fenfluramine; Macaca mulatta; Male; Narcotics; Phentermine; Piperazines; Reaction Time; Self Administration; Serotonin Agents | 1997 |
Dose-response analysis in risk assessment: evaluation of behavioral specificity.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Macaca mulatta; Neurotoxins; Piperazines; Probability; Risk Assessment | 1996 |
The rate hypothesis and agonist substitution approaches to cocaine abuse treatment.
Topics: Animals; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Humans; Mazindol; Piperazines; Substance-Related Disorders | 1998 |
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats.
Topics: Animals; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Diazepam; Dizocilpine Maleate; Hemodynamics; Male; Piperazines; Rats; Rats, Sprague-Dawley; Substance-Related Disorders | 1997 |
D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Autoradiography; Benzazepines; Cocaine; Crosses, Genetic; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Female; Fetus; Male; Mice; Mice, Knockout; Mice, Transgenic; Piperazines; Pregnancy; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D1; RNA, Messenger; Signal Transduction; Suprachiasmatic Nucleus; Transcription, Genetic; Tritium | 1997 |
Chronic administration of the selective dopamine uptake inhibitor GBR 12,909, but not cocaine, produces marked decreases in dopamine transporter density.
Topics: Animals; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Piperazines; Rats; Rats, Sprague-Dawley | 1997 |
A simple probe measures the pharmacokinetics of[125I]RTI-55 in mouse brain in vivo.
Topics: Absorptiometry, Photon; Animals; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Iodine Radioisotopes; Male; Mice; Paroxetine; Piperazines; Radiometry; Selective Serotonin Reuptake Inhibitors; Serotonin | 1997 |
Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine.
Topics: Animals; Carrier Proteins; Cocaine; Desipramine; Dextroamphetamine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Multivariate Analysis; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Symporters | 1997 |
gamma-Aminobutyric acidA agonists differentially augment gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice.
Topics: Animals; Behavior, Animal; Benzazepines; Cocaine; Dopamine Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Piperazines | 1998 |
Apical and basolateral uptake and intracellular fate of dopamine precursor L-dopa in LLC-PK1 cells.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Biological Transport; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Epithelial Cells; Kidney Tubules, Proximal; Kinetics; Levodopa; LLC-PK1 Cells; Piperazines; Swine | 1998 |
Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.
Topics: Animals; Benzhydryl Compounds; Carrier Proteins; Cell Membrane; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1998 |
GABAergic modulation of ventral pallidal dopamine release studied by in vivo microdialysis in the freely moving rat.
Topics: Animals; Baclofen; Cocaine; Dopamine; Dopamine Uptake Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Picrotoxin; Piperazines; Rats; Rats, Wistar | 1998 |
Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
Topics: Animals; Carrier Proteins; Cell Line; Citalopram; Cloning, Molecular; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Transfection | 1998 |
Modulation of cocaine-induced motor activity in the rat by opioid receptor agonists.
Topics: Animals; Cisterna Magna; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections; Male; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors | 1998 |
Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors?
Topics: Animals; Body Temperature; Cocaine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Hypothermia; Male; Piperazines; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Reflex, Startle; Salicylamides; Serotonin Antagonists | 1998 |
Generalization of D-, L- and DL-chlorpheniramine and zolantidine to the discriminative stimulus effects of cocaine and methamphetamine.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzothiazoles; Chlorpheniramine; Clomipramine; Cocaine; Desipramine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Stimulus; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Methamphetamine; Middle Aged; Phenoxypropanolamines; Piperazines; Piperidines; Rats; Rats, Inbred F344; Thiazoles | 1997 |
Novel rhenium complexes derived from alpha-tropanol as potential ligands for the dopamine transporter.
Topics: Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Crystallography, X-Ray; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rhenium; Structure-Activity Relationship; Tropanes | 1998 |
Repeated injection of GBR 12909, but not cocaine or WIN 35,065-2, into the ventral tegmental area induces behavioral sensitization.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Injections; Male; Microdialysis; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 1998 |
Iodine-123 labelled nor-beta-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine Uptake Inhibitors; Fluvoxamine; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Radionuclide Imaging; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tropanes | 1998 |
Effects of phentermine on responding maintained under multiple fixed-ratio schedules of food and cocaine presentation in the rhesus monkey.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Eating; Illicit Drugs; Macaca mulatta; Male; Phentermine; Piperazines | 1999 |
Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine.
Topics: Amphetamine; Analysis of Variance; Animals; Caffeine; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thiazepines | 1999 |
Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Depression, Chemical; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Papio; Piperazines; Self Administration; Tomography, Emission-Computed | 1999 |
Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period.
Topics: Animals; Autoradiography; Basal Ganglia; Benzazepines; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Female; Haloperidol; Male; Piperazines; Prosencephalon; Protein Binding; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Sex Factors; Time Factors; Weaning | 1999 |
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
Topics: Animals; Body Temperature; Bupropion; Cocaine; Discrimination, Psychological; Female; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Nicotine; Oocytes; Pain; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Seizures; Structure-Activity Relationship; Tropanes; Xenopus laevis | 1999 |
The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Body Weight; Cadmium Chloride; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Drug Tolerance; Eating; Male; Piperazines; Procaine; Quinpirole; Rats; Rats, Sprague-Dawley | 1999 |
Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration.
Topics: Animals; Behavior, Addictive; Benzazepines; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Heroin; Male; Narcotics; Piperazines; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome | 1999 |
Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations.
Topics: Amphetamine; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Anxiety Agents; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid; Saimiri; Selective Serotonin Reuptake Inhibitors | 1999 |
Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity.
Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Dopamine Uptake Inhibitors; Drug Tolerance; Fluoxetine; Infusion Pumps, Implantable; Male; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Time Factors | 1999 |
Pharmacological characterization of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)n ortropane as a selective and potent inhibitor of the neuronal dopamine transporter.
Topics: Animals; Autoradiography; Biological Transport, Active; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Nortropanes; Piperazines; Protein Binding; Radiopharmaceuticals; Rats; Rats, Wistar; Visual Cortex | 1999 |
Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain.
Topics: Anesthesia, Inhalation; Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Isoflurane; Kinetics; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Piperazines; Receptors, Dopamine D2; Time Factors; Tomography, Emission-Computed; Wakefulness | 1999 |
[3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue.
Topics: Amphetamine; Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Tritium | 1999 |
A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and PET experiments.
Topics: Animals; Brain; Bromine Radioisotopes; Cerebellum; Cerebral Cortex; Citalopram; Cocaine; Corpus Striatum; Dopamine; Kinetics; Male; Maprotiline; Nortropanes; Papio; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Thalamus; Tissue Distribution; Tomography, Emission-Computed | 1999 |
Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Piperazines; Saimiri; Self Administration; Statistics as Topic; Time Factors | 2000 |
Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Piperazines; Time Factors; Tomography, Emission-Computed | 2000 |
Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys.
Topics: Animals; Cocaine; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Microdialysis; Piperazines; Saimiri | 2000 |
Changes in dopamine transporter and c-Fos expression in the nucleus accumbens of alcohol-tolerant rats.
Topics: Alcoholism; Animals; Carrier Proteins; Central Nervous System Depressants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ethanol; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Serotonin | 2000 |
Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors.
Topics: Animals; Brain; Carrier Proteins; Cell Differentiation; Cocaine; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Neurons; Neurotransmitter Agents; PC12 Cells; Piperazines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2000 |
A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats.
Topics: Amphetamine; Animals; Apomorphine; Cocaine; Corpus Striatum; Dopamine Agonists; Dopamine Uptake Inhibitors; Immunohistochemistry; Injections, Intraperitoneal; Male; Nalidixic Acid; Naphthyridines; Nomifensine; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Staining and Labeling | 2000 |
Effect of cocaine, nomifensine, GBR 12909 and WIN 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine.
Topics: Animals; Artifacts; Calibration; Carbon; Coated Materials, Biocompatible; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electrochemistry; Electrodes, Implanted; Equipment Failure; Fluorocarbon Polymers; Male; Microelectrodes; Nomifensine; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2000 |
Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cholinergic Fibers; Cocaine; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Piperazines; Raclopride; Receptors, Dopamine D2; Scopolamine; Synapses; Tomography, Emission-Computed; Wakefulness | 2000 |
Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons.
Topics: Action Potentials; Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Ventral Tegmental Area | 2000 |
Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by reinforcing drugs.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethanol; Extracellular Space; Illicit Drugs; Male; Microdialysis; Morphine; Nicotine; Piperazines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Synaptic Transmission | 2000 |
Chamber-specific alterations of noradrenaline uptake (uptake(1)) in right ventricles of monocrotaline-treated rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Heart Failure; Heart Ventricles; Hypertrophy; In Vitro Techniques; Male; Membranes; Monocrotaline; Norepinephrine; Piperazines; Rats; Rats, Wistar; Tritium | 2000 |
Serotonin-mediated striatal dopamine release involves the dopamine uptake site and the serotonin receptor.
Topics: Animals; Bicuculline; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; Ketanserin; Male; Methiothepin; Mice; Mice, Inbred C57BL; Oxymetazoline; Piperazines; Quinoxalines; Quipazine; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Macaca mulatta; Male; Piperazines | 2000 |
A comparison of cocaine, GBR 12909, and phentermine self-administration by rhesus monkeys on a progressive-ratio schedule.
Topics: Adrenergic Agents; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Macaca mulatta; Male; Phentermine; Piperazines; Reinforcement Schedule; Self Administration | 2001 |
Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter.
Topics: Animals; Benzhydryl Compounds; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Ligands; Macaca mulatta; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Piperazines; Piperidines; Radioligand Assay; Tritium | 2001 |
Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine.
Topics: Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2001 |
Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene.
Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extracellular Space; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Morpholines; Nerve Tissue Proteins; Nucleus Accumbens; Piperazines; Reboxetine; Reinforcement, Psychology | 2001 |
Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys.
Topics: Animals; Benztropine; Cocaine; Dopamine Uptake Inhibitors; Female; Macaca mulatta; Male; Piperazines; Reaction Time; Reinforcement Schedule; Self Administration | 2001 |
Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cocaine; Discrimination, Psychological; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2001 |
Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Biogenic Monoamines; Biological Clocks; Carrier Proteins; Cocaine; Desipramine; Dizocilpine Maleate; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fluoxetine; Globus Pallidus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Periodicity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 2001 |
Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine.
Topics: Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Generalization, Stimulus; Male; Methamphetamine; Motor Activity; Neurons; Piperazines; Rats; Rats, Sprague-Dawley | 2001 |
Behavioral responses to dopamine agonists in adult rats exposed to cocaine during the preweaning period.
Topics: Animals; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Female; Male; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Sex Factors; Weaning | 2001 |
Similar enhancement of the discriminative stimulus effects of cocaine and GBR 12909 by heroin in squirrel monkeys.
Topics: Animals; Cocaine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Heroin; Male; Narcotics; Piperazines; Saimiri | 2001 |
Repeated cocaine administration into the rat ventral tegmental area produces behavioral sensitization to a systemic cocaine challenge.
Topics: Animals; Arousal; Cocaine; Drug Synergism; Injections, Intraperitoneal; Male; Microinjections; Motor Activity; Piperazines; Premedication; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Ventral Tegmental Area | 2001 |
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.
Topics: Animals; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Frontal Lobe; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Symporters; Synaptosomes | 2002 |
Effects of GBR 12909, WIN 35,428 and indatraline on cocaine self-administration and cocaine seeking in rats.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Indans; Male; Methylamines; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Self Administration | 2002 |
Locomotor activity induced by noncompetitive NMDA receptor antagonists versus dopamine transporter inhibitors: opposite strain differences in inbred long-sleep and short-sleep mice.
Topics: Amphetamine; Animals; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Female; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Motor Activity; Nerve Tissue Proteins; Piperazines; Receptors, N-Methyl-D-Aspartate; Sleep; Species Specificity; Tritium | 2002 |
Effects of dopamine agonists and antagonists on locomotor activity in male and female rats.
Topics: Animals; Benzazepines; Cocaine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Piperazines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Sex Characteristics | 2002 |
Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors.
Topics: Animals; Caudate Nucleus; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Nucleus Accumbens; Piperazines; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys.
Topics: Aging; Animals; Benzazepines; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Male; Microdialysis; Piperazines; Raclopride; Tomography, Emission-Computed | 2002 |
Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens.
Topics: Analysis of Variance; Animals; Area Under Curve; Autoreceptors; Benzothiazoles; Cocaine; Cocaine-Related Disorders; Cross-Over Studies; Dopamine Agonists; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Piperazines; Pramipexole; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 2002 |
Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Macaca mulatta; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 2003 |
Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Cocaine; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Male; Mice; Mice, Inbred DBA; Motor Activity; Piperazines; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2004 |
Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors.
Topics: Animals; Carrier Proteins; Citalopram; Cocaine; Discrimination, Psychological; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Heroin; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Saimiri; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Symporters; Thiophenes; Vesicular Biogenic Amine Transport Proteins | 2004 |
Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice.
Topics: Animals; Baclofen; Cocaine; Dopamine Uptake Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Kindling, Neurologic; Male; Mice; Piperazines; Receptors, GABA-A; Receptors, GABA-B; Seizures | 2004 |
Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Discrimination Learning; Dopamine Agents; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Methamphetamine; Methylphenidate; Microdialysis; Piperazines; Saimiri | 2004 |
Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.
Topics: Amino Acid Substitution; Benztropine; Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kidney; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Muscarinic Antagonists; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Piperazines; Protein Binding; Sodium; Structure-Activity Relationship; Zinc | 2004 |
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Topics: Animals; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extracellular Space; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Nucleus Accumbens; Piperazines; Prefrontal Cortex; Putamen; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereotaxic Techniques | 2004 |
Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex.
Topics: Animals; Biological Transport; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Synaptosomes; Time Factors; Tritium | 2004 |
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.
Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Northern; Central Nervous System; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors | 2004 |
Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats.
Topics: Animals; Benzazepines; Cocaine; Conditioning, Operant; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Food; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reinforcement, Psychology; Salicylamides; Self Administration; Tetrahydronaphthalenes | 2004 |
Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Binding Sites; Binding, Competitive; Biological Transport; Cell Line; Cell Membrane; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutation; Nerve Tissue Proteins; Norepinephrine; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism; Synaptosomes; Tritium | 2004 |
Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity.
Topics: Binding Sites; Binding, Competitive; Brain Chemistry; Buffers; Cell Line; Cell Membrane; Cocaine; Dopamine Uptake Inhibitors; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Radioligand Assay; Reproducibility of Results; Symporters; Temperature | 2005 |
Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter.
Topics: Animals; Benzhydryl Compounds; Binding, Competitive; Brain; Cell Line; Cocaine; Dopamine; Humans; In Vitro Techniques; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Agents; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2005 |
Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs.
Topics: Animals; Benztropine; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Piperazines | 2005 |
Behavioral disinhibition requires dopamine receptor activation.
Topics: Amphetamine; Animals; Behavior, Animal; Benzazepines; Cocaine; Desipramine; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Nicotine; Piperazines; Rats; Rats, Wistar; Receptors, Dopamine; Serotonin | 2006 |
Nicotine as a conditioned stimulus: impact of attention-deficit/hyperactivity disorder medications.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Bupropion; Cocaine; Conditioning, Operant; Conditioning, Psychological; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Psychological; Male; Methylphenidate; Nicotine; Nicotinic Antagonists; Piperazines; Propylamines; Rats; Rats, Sprague-Dawley | 2007 |
Ex vivo evaluation of N-(3-[18F]fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-fluorophenyl)nortropane in rats.
Topics: Animals; Binding, Competitive; Bone and Bones; Cerebellum; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluorine Radioisotopes; Limbic System; Male; Nortropanes; Piperazines; Radioligand Assay; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2008 |
Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Injections, Intravenous; Male; Piperazines; Rats; Rats, Sprague-Dawley; Time Factors; Ventral Tegmental Area | 2008 |
Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Embryo, Mammalian; HIV Envelope Protein gp120; Mesencephalon; Neurons; Piperazines; Protein Binding; Rats; Serotonin Plasma Membrane Transport Proteins; tat Gene Products, Human Immunodeficiency Virus | 2008 |
Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.
Topics: Animals; Carbazoles; Cocaine; Combinatorial Chemistry Techniques; Dopamine Plasma Membrane Transport Proteins; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship | 2008 |
Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.
Topics: Animals; Asparagine; Aspartic Acid; Benztropine; Binding, Competitive; Cell Line, Transformed; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Leucine; Models, Molecular; Mutation; Piperazines; Protein Binding; Protein Structure, Tertiary; Sodium; Structure-Activity Relationship; Transfection; Tritium; Tryptophan | 2008 |
Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Male; Mice; Norepinephrine; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin; Taste | 2009 |
High resolution micro-SPECT scanning in rats using 125I beta-CIT: effects of chronic treatment with carbamazepine.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Brain Mapping; Carbamazepine; Cocaine; Dopamine Uptake Inhibitors; Iodine Radioisotopes; Male; Piperazines; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon | 2009 |
Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux.
Topics: Animals; Avoidance Learning; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Male; Methamphetamine; Methylphenidate; Microdialysis; Motor Activity; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2010 |
In vivo voltammetric monitoring of catecholamine release in subterritories of the nucleus accumbens shell.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Desipramine; Dopamine; Electric Stimulation; Male; Medial Forebrain Bundle; Microelectrodes; Neural Pathways; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Substantia Nigra; Synaptic Transmission; Ventral Tegmental Area | 2010 |
Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.
Topics: Adrenergic Uptake Inhibitors; Animals; Benztropine; Binding, Competitive; Cell Line, Tumor; Cell Membrane; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Histamine H1 Antagonists; Humans; Kinetics; Male; Mice; Mice, 129 Strain; Mice, Inbred Strains; Mice, Knockout; Neuroblastoma; Piperazines; Pirenzepine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Selective Serotonin Reuptake Inhibitors; Sodium; Triprolidine | 2010 |
Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909.
Topics: Animals; Avoidance Learning; Cocaine; Conditioning, Classical; Dopamine; Dopamine Uptake Inhibitors; Male; Piperazines; Rats; Rats, Sprague-Dawley; Taste | 2012 |
Role of dopamine tone in the pursuit of brain stimulation reward.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Male; Microdialysis; Models, Biological; Piperazines; Rats; Rats, Long-Evans; Reward; Self Stimulation; Time Factors | 2012 |
Ablation of neurons expressing melanin-concentrating hormone (MCH) in adult mice improves glucose tolerance independent of MCH signaling.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Eating; Glucose; Glucose Tolerance Test; Hypothalamic Hormones; Melanins; Mice; Motor Activity; Neurons; Piperazines; Pituitary Hormones; Signal Transduction | 2013 |
Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Behavior, Animal; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Exploratory Behavior; Fluoxetine; Flupenthixol; Idazoxan; Male; Motor Activity; Piperazines; Play and Playthings; Propylamines; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Social Behavior | 2014 |
Involvement of reactive oxygen species in cocaine-taking behaviors in rats.
Topics: Animals; Antioxidants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cyclic N-Oxides; Dopamine; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Male; Neuroprotective Agents; Nucleus Accumbens; Oxidative Stress; Piperazines; Rats, Sprague-Dawley; Reactive Oxygen Species; Reinforcement Schedule; Self Administration; Spin Labels | 2015 |
Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport.
Topics: Animals; Binding Sites; CHO Cells; Cocaine; Cricetinae; Cricetulus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Lysine; Models, Molecular; Mutation; Piperazines; Protein Binding; Protein Conformation; tat Gene Products, Human Immunodeficiency Virus; Tyrosine | 2015 |
Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Cocaine; Conditioning, Operant; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Flupenthixol; Idazoxan; Male; Methylphenidate; Motivation; Neuropsychological Tests; Norepinephrine; Piperazines; Random Allocation; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Dopamine; Social Behavior | 2016 |
Further delineation between typical and atypical dopamine uptake inhibitors: effects on food-maintained behavior and food consumption.
Topics: Animals; Behavior, Animal; Benztropine; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2017 |
Behavioral profile of adult zebrafish acutely exposed to a selective dopamine uptake inhibitor, GBR 12909.
Topics: Animals; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Zebrafish | 2023 |
Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.
Topics: Animals; Brain; Carrier Proteins; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Serotonin Plasma Membrane Transport Proteins; Symporters; Tropanes | 2004 |
Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine tr
Topics: Animals; Benzhydryl Compounds; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cocaine; Corpus Striatum; Crystallography, X-Ray; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Molecular Conformation; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioligand Assay; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters | 2004 |