Compounds > cocaine

cocaine and u 69593

cocaine has been researched along with u 69593 in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (31.03)18.2507
2000's18 (62.07)29.6817
2010's2 (6.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Babovic-Vuksanovic, D; Heidbreder, CA; Shippenberg, TS; Shoaib, M1
Heidbreder, CA; Shippenberg, TS1
Goldberg, SR; Heidbreder, CA; Shippenberg, TS1
Heidbreder, C; LeFevour, A; Shippenberg, TS1
Mash, DC; Partilla, J; Rice, KC; Rothman, RB; Staley, JK1
LeFevour, A; Shippenberg, TS; Thompson, AC1
Heidbreder, CA; Partridge, B; Schenk, S; Shippenberg, TS1
Holtzman, SG; Waddell, AB1
Chefer, V; Shippenberg, TS; Thompson, AC1
Holtzman, SG; Powell, KR1
De Vries, TJ; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G1
Partridge, B; Schenk, S; Shippenberg, TS2
Chefer, VI; Hope, B; Morón, JA; Rea, W; Shippenberg, TS1
Justice, JB; Sharpe, LG; Shippenberg, TS; Thompson, AC; Vaughan, RA; Zapata, A1
Collins, SL; D'Addario, C; Izenwasser, S1
Partridge, B; Schenk, S1
Collins, SL; D'Addario, C; Gerdes, RM; Izenwasser, S1
Fields, HL; Hjelmstad, GO; Kim, JA; Pollak, KA1
Chefer, VI; Shippenberg, TS1
Candeletti, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P1
Kaminski, RM; Shippenberg, TS; Witkin, JM1
Candeletti, S; D'Addario, C; Di Benedetto, M; Romualdi, P1
Puig-Ramos, A; Santiago, GS; Segarra, AC1
Aberg, M; Collins, SL; Fernandez, JB; Izenwasser, S; Kumar, A; Zakharova, E1
Carlezon, WA; Chartoff, EH; Cohen, BM; Todtenkopf, MS; Tomasiewicz, HC1
Kivell, B; Morani, AS; Prisinzano, TE; Schenk, S1
Ho, A; Kreek, MJ; Piras, AP; Schlussman, SD; Zhou, Y1
Bechtholt, AJ; Carlezon, WA; Chartoff, EH; Cohen, BM; Liu-Chen, LY; Onvani, S; Potter, D; Rudolph, U; Schütz, G; Van't Veer, A; Wang, Y1

Other Studies

29 other study(ies) available for cocaine and u 69593

ArticleYear
Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Locomotion; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride

1995
U-69593 prevents cocaine sensitization by normalizing basal accumbens dopamine.
    Neuroreport, 1994, Sep-08, Volume: 5, Issue:14

    Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dopamine; Extracellular Space; Male; Microdialysis; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior

1994
The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat.
    Brain research, 1993, Jul-09, Volume: 616, Issue:1-2

    Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Drug Administration Schedule; Male; Motor Activity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reference Values; Stereotyped Behavior; Time Factors

1993
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward

1996
Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amygdala; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Overdose; Female; Fentanyl; Gyrus Cinguli; Humans; Isothiocyanates; Kinetics; Male; Morphinans; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Tissue Distribution; Up-Regulation

1997
Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the kappa-opioid receptor agonist U69593.
    European journal of pharmacology, 1998, Mar-12, Volume: 345, Issue:1

    Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Conditioning, Operant; Cues; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward

1998
Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective kappa-opioid receptor agonist.
    Synapse (New York, N.Y.), 1998, Volume: 30, Issue:3

    Topics: Analgesics; Analysis of Variance; Animals; Benzeneacetamides; Caudate Nucleus; Cocaine; Dopamine; Drug Interactions; Kinetics; Limbic System; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors

1998
Modulation of cocaine-induced antinociception by opioid-receptor agonists.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2

    Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa

1999
Modulation of cocaine-induced sensitization by kappa-opioid receptor agonists. Role of the nucleus accumbens and medial prefrontal cortex.
    Annals of the New York Academy of Sciences, 1999, Jun-29, Volume: 877

    Topics: Animals; Benzeneacetamides; Cocaine; Dopamine; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

1999
Modulation of the discriminative stimulus effects of d-amphetamine by mu and kappa opioids in squirrel monkeys.
    Pharmacology, biochemistry, and behavior, 2000, Jan-01, Volume: 65, Issue:1

    Topics: Animals; Benzeneacetamides; Benzofurans; Cocaine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri

2000
Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine.
    Psychopharmacology, 2000, Volume: 150, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Central Nervous System Stimulants; Cocaine; Male; Motor Activity; Psychomotor Agitation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

2000
Reinstatement of extinguished drug-taking behavior in rats: effect of the kappa-opioid receptor agonist, U69593.
    Psychopharmacology, 2000, Volume: 151, Issue:1

    Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Extinction, Psychological; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2000
Kappa-opioid receptor activation prevents alterations in mesocortical dopamine neurotransmission that occur during abstinence from cocaine.
    Neuroscience, 2000, Volume: 101, Issue:3

    Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Cocaine-Related Disorders; Dopamine; Drug Interactions; Extracellular Space; Male; Microdialysis; Motor Activity; Neural Pathways; Neurons; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Synaptic Transmission; Synaptosomes; Ventral Tegmental Area

2000
Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-15, Volume: 20, Issue:24

    Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug Antagonism; Extracellular Space; Injections, Intraperitoneal; Injections, Subcutaneous; Iodine Radioisotopes; Linear Models; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Naltrexone; Nerve Tissue Proteins; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2000
Effects of the kappa-opioid receptor agonist, U69593, on the development of sensitization and on the maintenance of cocaine self-administration.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:4

    Topics: Animals; Behavior, Addictive; Behavior, Animal; Benzeneacetamides; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Drug Administration Schedule; Injections, Intravenous; Male; Photic Stimulation; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration

2001
Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission.
    European journal of pharmacology, 2001, Aug-24, Volume: 426, Issue:1-2

    Topics: Analgesics; Animals; Autoradiography; Benzazepines; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Opioid, kappa; Sulpiride; Synaptic Transmission; Time Factors; Tyrosine 3-Monooxygenase

2001
Effect of the kappa-opioid receptor agonist, U69593, on reinstatement of extinguished amphetamine self-administration behavior.
    Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:4

    Topics: Amphetamine; Analgesics; Animals; Behavior, Addictive; Benzeneacetamides; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration

2001
Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity.
    Behavioural pharmacology, 2001, Volume: 12, Issue:4

    Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Naltrexone; Nerve Net; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2001
A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Apr-13, Volume: 101, Issue:15

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Environment; Excitatory Amino Acid Antagonists; Male; Microinjections; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Ventral Tegmental Area

2004
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
    The European journal of neuroscience, 2006, Volume: 23, Issue:1

    Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines

2006
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS.
    Neuroscience, 2007, Jan-05, Volume: 144, Issue:1

    Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin

2007
Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.
    Neuropharmacology, 2007, Volume: 52, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Pyrrolidines; Receptors, Opioid, kappa; Seizures

2007
The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
    Brain research bulletin, 2007, Jun-15, Volume: 73, Issue:1-3

    Topics: Analgesics; Animals; Benzeneacetamides; Blotting, Western; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine and cAMP-Regulated Phosphoprotein 32; Hippocampus; Injections; Male; Phosphorylation; Prefrontal Cortex; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Threonine

2007
U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats.
    Behavioral neuroscience, 2008, Volume: 122, Issue:1

    Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Estradiol; Estrogens; Female; Motor Activity; Ovariectomy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Time Factors

2008
Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593 on cocaine-stimulated activity.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Animals; Autoradiography; Benzeneacetamides; Brain Chemistry; Citalopram; Cocaine; In Vitro Techniques; Male; Motor Activity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins

2008
The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward.
    Biological psychiatry, 2008, Dec-01, Volume: 64, Issue:11

    Topics: Analysis of Variance; Animals; Benzeneacetamides; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Electric Stimulation; Male; Medial Forebrain Bundle; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Self Stimulation; Time Factors

2008
Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Benzeneacetamides; Cocaine; Diterpenes, Clerodane; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration

2009
Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area.
    Neuroscience, 2010, Aug-25, Volume: 169, Issue:2

    Topics: Animals; Autoradiography; Benzeneacetamides; Cocaine; Guanosine 5'-O-(3-Thiotriphosphate); Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substantia Nigra; Ventral Tegmental Area

2010
Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:8

    Topics: Animals; Anti-Anxiety Agents; Benzeneacetamides; Brain; Cocaine; Dopaminergic Neurons; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuronal Plasticity; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa

2013