cocaine and u-50488

cocaine has been researched along with u-50488 in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	14 (36.84)	18.2507
2000's	12 (31.58)	29.6817
2010's	11 (28.95)	24.3611
2020's	1 (2.63)	2.80

Authors

Authors	Studies
Masukawa, Y; Misawa, M; Nagase, H; Shiozaki, Y; Suzuki, T	1
Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J	1
Babovic-Vuksanovic, D; Heidbreder, CA; Shippenberg, TS; Shoaib, M	1
Archer, S; Glick, SD; Maisonneuve, IM	1
Berger, SP; Bolanos, CA; Crawford, CA; Hall, S; McDougall, SA	1
Heidbreder, C; LeFevour, A; Shippenberg, TS	1
Gerrits, MA; Kuzmin, AV; Semenova, S; Van Ree, JM; Zvartau, EE	1
Kishimoto, Y; Maeda, J; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M	1
Lin, CE; Mello, NK; Negus, SS; Portoghese, PS	1
Mash, DC; Partilla, J; Rice, KC; Rothman, RB; Staley, JK	1
Kameyama, T; Mori, E; Ukai, M	1
Bhargava, HN; Cao, YJ	1
Mello, NK; Negus, SS	1
Kantak, KM; Riberdy, A; Spealman, RD	1
De Vries, TJ; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G	1
Mori, T; Nagase, H; Narita, M; Nomura, M; Suzuki, T	1
Bidlack, JM; Gekker, G; Hu, S; Lokensgard, JR; Peterson, PK; Wentland, MP	1
Negus, SS	1
Raffa, RB; Stagliano, GW; Umeda, S	1
Ito, S; Mori, T; Narita, M; Sawaguchi, T; Suzuki, T	1
Chavkin, C; Land, BB; Li, S; McLaughlin, JP; Pintar, JE	1
Alekseenko, OV; Gerrits, MA; Kudryavtseva, NN; Van Ree, JM	1
Raffa, RB; Stagliano, GW; Tallarida, RJ	1
Antapasis, J; Bolaños Guzmán, CA; Herrera, CM; Poveromo, LB; Wiley, MD	1
Kivell, B; Morani, AS; Prisinzano, TE; Schenk, S	1
Aita, M; Bruchas, MR; Chavkin, C; Giardino, WJ; Hnasko, TS; Land, BB; Messinger, D; Palmiter, RD; Schattauer, S	1
Charntikov, S; Cortez, AM; Crawford, CA; Der-Ghazarian, T; Horn, LR; McDougall, SA	1
Chavkin, C; Li, S; Schindler, AG	1
Der-Ghazarian, T; Herbert, MS; McDougall, SA; Palmer, AG	1
Isotani, K; Miyatake, M; Mori, T; Narita, M; Suzuki, T; Tomiyasu, S; Tsukiyama, Y; Yoshizawa, K	1
Chudnovskaya, D; Cowan, A; Huang, P; Liu-Chen, LY; Rasakham, K; Wang, YJ	1
Carlezon, WA; Muschamp, JW; Nemeth, CL; Nestler, EJ; Robison, AJ	1
Aldrich, JV; Eans, SO; Ganno, ML; McLaughlin, JP; Patkar, KA; Reilley, KJ; Senadheera, SN	1
Al-Hasani, R; Bruchas, MR; Foshage, AM; McCall, JG	1
Chavkin, C; Ehrich, JM; Phillips, PE	1
Furbish, AB; Heinsbroek, JA; Peters, J	1
Kreek, MJ; Reed, B; Windisch, KA	1
Ben-Ezra, A; Dunn, A; Erazo, J; Kreek, MJ; Morochnik, M; Pikus, P; Reed, B; Windisch, K	1

Trials

1 trial(s) available for cocaine and u-50488

Article	Year
One-trial cocaine-induced behavioral sensitization in preweanling rats: role of contextual stimuli. Experimental and clinical psychopharmacology, 2010, Volume: 18, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Female; Locomotion; Male; Methylphenidate; Motor Activity; Neuroprotective Agents; Physical Stimulation; Rats; Rats, Sprague-Dawley	2010

Article

Year

One-trial cocaine-induced behavioral sensitization in preweanling rats: role of contextual stimuli.

Experimental and clinical psychopharmacology, 2010, Volume: 18, Issue:3

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Female; Locomotion; Male; Methylphenidate; Motor Activity; Neuroprotective Agents; Physical Stimulation; Rats; Rats, Sprague-Dawley

2010

Other Studies

37 other study(ies) available for cocaine and u-50488

Article	Year
The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference. Japanese journal of pharmacology, 1992, Volume: 58, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Buprenorphine; Chlorides; Cocaine; Conditioning, Psychological; Lithium; Lithium Chloride; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu	1992
Kappa opioid inhibition of morphine and cocaine self-administration in rats. Brain research, 1995, May-29, Volume: 681, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration	1995
Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Locomotion; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride	1995
U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats. Neuroscience letters, 1994, Nov-07, Volume: 181, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dopamine; Extracellular Space; Female; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1994
The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. Psychopharmacology, 1995, Volume: 120, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Immunohistochemistry; Locomotion; Male; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors	1995
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward	1996
Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice. European journal of pharmacology, 1997, Mar-05, Volume: 321, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration	1997
Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats. European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Narcotics; Pyrrolidines; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders	1997
Effects of kappa opioids on cocaine self-administration by rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders	1997
Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amygdala; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Overdose; Female; Fentanyl; Gyrus Cinguli; Humans; Isothiocyanates; Kinetics; Male; Morphinans; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Tissue Distribution; Up-Regulation	1997
Modulatory effects of morphine, U-50488H and 1,3-di-(2-tolyl)guanidine on cocaine-like discriminative stimulus in the rat using two-choice discrete-trial avoidance paradigm. Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Avoidance Learning; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Guanidines; Male; Morphine; Rats; Receptors, Opioid	1997
Interactions of cocaine with morphine, U-50,488H and [D-Pen2, D-Pen5]enkaphalin. Peptides, 1998, Volume: 19, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Male; Mice; Morphine; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1998
Effects of kappa opioid agonists on the discriminative stimulus effects of cocaine in rhesus monkeys. Experimental and clinical psychopharmacology, 1999, Volume: 7, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylketocyclazocine; Macaca mulatta; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid, kappa; Salicylamides	1999
Cocaine-opioid interactions in groups of rats trained to discriminate different doses of cocaine. Psychopharmacology, 1999, Volume: 147, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Morphine; Narcotics; Rats; Rats, Wistar	1999
Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine. Psychopharmacology, 2000, Volume: 150, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Central Nervous System Stimulants; Cocaine; Male; Motor Activity; Psychomotor Agitation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa	2000
Effects of a newly synthesized kappa-opioid receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats. Psychopharmacology, 2002, Volume: 161, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Conditioning, Psychological; Discrimination Learning; Dose-Response Relationship, Drug; Male; Morphinans; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; Reward; Spiro Compounds	2002
Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Cells, Cultured; Cocaine; Enzyme Activation; Enzyme Inhibitors; HIV-1; Humans; Microglia; Mitogen-Activated Protein Kinases; Receptors, CCR5; Receptors, Opioid, kappa; Up-Regulation; Virus Replication	2004
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys. Psychopharmacology, 2004, Volume: 176, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Eating; Macaca mulatta; Male; Naltrexone; Receptors, Opioid, kappa	2004
Cocaine and kappa-opioid withdrawal in Planaria blocked by D-, but not L-, glucose. Brain research, 2004, Aug-27, Volume: 1018, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Behavior, Addictive; Carbohydrate Conformation; Cocaine; Disease Models, Animal; Glucose; Narcotic Antagonists; Opioid-Related Disorders; Planarians; Receptors, Opioid, kappa; Substance Withdrawal Syndrome	2004
Combined effects of psychostimulants and morphine on locomotor activity in mice. Journal of pharmacological sciences, 2004, Volume: 96, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Methamphetamine; Mice; Morphine; Motor Activity	2004
Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Interactions; Enkephalins; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Time Factors	2006
Chronic cocaine injections attenuate behavioral response of kappa-opioid receptors to U-50,488H agonist. Bulletin of experimental biology and medicine, 2005, Volume: 140, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Cocaine; Exploratory Behavior; Male; Mice; Mice, Inbred C57BL; Motor Activity; Receptors, Opioid, kappa	2005
Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria. Brain research, 2006, Oct-09, Volume: 1114, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Planarians; Receptors, Opioid, kappa; Substance Withdrawal Syndrome	2006
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Food Preferences; Male; Methylphenidate; Motor Activity; Naltrexone; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Psychological	2009
Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Benzeneacetamides; Cocaine; Diterpenes, Clerodane; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration	2009
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the United States of America, 2009, Nov-10, Volume: 106, Issue:45 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Cocaine; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Physiological; Ventral Tegmental Area	2009
Age-dependent effects of kappa-opioid receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate-putamen: an in vivo microdialysis study. Neuroscience, 2010, Aug-11, Volume: 169, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Animals, Suckling; Caudate Nucleus; Cocaine; Dopamine; Microdialysis; Microinjections; Motor Activity; Putamen; Rats; Receptors, Opioid, kappa; Second Messenger Systems; Stereotyped Behavior	2010
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Exploratory Behavior; Male; Mental Recall; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reward; Stress, Psychological; Swimming	2010
Role of dopamine D2 and D3 receptors in mediating the U-50,488H discriminative cue: comparison with methamphetamine and cocaine. Addiction biology, 2012, Volume: 17, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Apomorphine; Cocaine; Discrimination Learning; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Methamphetamine; Rats; Rats, Inbred F344; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes	2012
Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Mice; Motor Activity; Movement; Naltrexone; Narcotic Antagonists; Posture; Rats; Receptors, Opioid, kappa; Sex Characteristics	2011
ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biological psychiatry, 2012, Jan-01, Volume: 71, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthetics, Local; Animals; Biophysics; Cocaine; Conditioning, Operant; Corpus Striatum; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypothalamic Area, Lateral; Male; Medial Forebrain Bundle; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos; Receptors, Opioid, kappa; Reward; Self Stimulation	2012
The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration. British journal of pharmacology, 2013, Volume: 169, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animals; Behavior, Animal; Blood-Brain Barrier; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Motor Activity; Peptides, Cyclic; Receptors, Opioid, kappa; Time Factors; Tissue Distribution	2013
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:12 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naltrexone; Propanolamines; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid, kappa	2013
Kappa opioid receptor activation potentiates the cocaine-induced increase in evoked dopamine release recorded in vivo in the mouse nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:13 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Cocaine; Conditioning, Operant; Dopamine; Electric Stimulation; Follow-Up Studies; Male; Medial Forebrain Bundle; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Receptors, Opioid, kappa; Reward; Time Factors	2014
A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:7 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Drug-Seeking Behavior; Extinction, Psychological; Imidazoles; Infusions, Intraventricular; Lithium Chloride; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Receptors, Opioid, kappa; Recurrence; Self Administration	2018
Naltrexone and nalmefene attenuate cocaine place preference in male mice. Neuropharmacology, 2018, 09-15, Volume: 140 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists	2018
Modulation of cocaine-related behaviors by low doses of the potent KOR agonist nalfurafine in male C57BL6 mice. Psychopharmacology, 2020, Volume: 237, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Addictive; Cocaine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphinans; Receptors, Opioid, kappa; Reward; Self Administration; Signal Transduction; Spiro Compounds	2020