cocaine has been researched along with quinidine in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (47.06) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 11 (32.35) | 29.6817 |
| 2010's | 5 (14.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Keserü, GM | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Nikolić, K; Popović, R; Svećenski, N | 1 |
| Suzuki, H | 1 |
| Barth, N; Muscholl, E | 1 |
| McIntosh, DA; Scales, B | 1 |
| Grobecker, H; Holtz, P; Palm, D | 1 |
| Boullin, DJ; O'Brien, RA | 2 |
| Morita, M; Nagata, M; Sugimoto, J | 1 |
| Kalsner, S | 1 |
| Mason, RG; Read, MS; Saba, SR; Shermer, RW | 1 |
| Ito, T; Morita, M; Sugimoto, J | 1 |
| Kretzschmar, R; Meyer, HJ | 1 |
| Brochmann-Hanssen, E; Fontan, CR | 1 |
| Pruett, JK; Woods, EF | 1 |
| Bailey, DN | 1 |
| Erzouki, HK; Goldberg, SR; Schindler, CW | 1 |
| POMERAT, CM; STRASSER, FF; YANG, WC | 1 |
| Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
| Heemstra, JM; Spiropulos, NG | 1 |
| Gouda, H; Handa, K; Hirono, S; Nakagome, I; Yamaotsu, N | 1 |
| Tikhonov, DB; Zhorov, BS | 1 |
1 trial(s) available for cocaine and quinidine
| Article | Year |
|---|---|
Quinidine inhibition of cocaethylene degradation in human serum in vitro: a preliminary study.
Topics: Anti-Arrhythmia Agents; Cholinesterases; Cocaine; Dopamine Uptake Inhibitors; Humans; Hydrolysis; Male; Quinidine | 1999 |
33 other study(ies) available for cocaine and quinidine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
[Conductometric determination of various alkaloid salts in dimethyl sulfoxide].
Topics: Alkaloids; Cocaine; Conductometry; Dimethyl Sulfoxide; Physostigmine; Pilocarpine; Quinidine; Scopolamine | 1976 |
Electrical responses of smooth muscle cells of the rabbit ear artery to adenosine triphosphate.
Topics: Action Potentials; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cocaine; Dose-Response Relationship, Drug; Ear, External; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Phentolamine; Quinidine; Rabbits; Theophylline | 1985 |
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Autonomic Fibers, Postganglionic; Cocaine; Desipramine; Doxepin; Drug Antagonism; Electric Stimulation; Female; Heart; Heart Rate; Iprindole; Male; Perfusion; Propranolol; Quinidine; Rabbits; Sympathetic Nervous System; Time Factors | 1974 |
Studies on the radiocalcium uptake and the adenosine triphosphatases of skeletal and cardiac sarcoplasmic reticulum fractions (SRF).
Topics: Adenosine Triphosphatases; Animals; Anti-Infective Agents, Local; Calcium; Calcium Isotopes; Cattle; Cocaine; Electric Stimulation; Electron Transport Complex IV; Filtration; Guinea Pigs; In Vitro Techniques; Microscopy, Electron; Muscles; Myocardium; Oleic Acids; Phenoxybenzamine; Phentolamine; Procaine; Quinidine; Rabbits; Sheep; Ultracentrifugation | 1968 |
[On the pharmacology of prenylamine].
Topics: Acetylcholine; Animals; Blood Pressure; Brain; Carbon Isotopes; Cats; Cocaine; Dopamine; Drug Synergism; Guinea Pigs; Heart; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Muscle, Smooth; Muscles; Myocardium; Nictitating Membrane; Norepinephrine; Prenylamine; Quinidine; Rats; Reserpine; Sympathomimetics; Tritium; Tyramine; Vas Deferens | 1968 |
Accumulation, storage and release of adrenergic neuron blocking agents and related drugs by human platelets.
Topics: Amiloride; Binding Sites; Blood Platelets; Carbon Isotopes; Cocaine; Desipramine; Dextroamphetamine; Ethylmaleimide; Guanethidine; Guanidines; Humans; Iodoacetates; Isoquinolines; Ouabain; Parasympatholytics; Quinidine; Reserpine; Serotonin; Tritium | 1972 |
Comparative studies on the pharmacological actions of anti-arrhythmics in isolated guinea-pig atria.
Topics: Ajmaline; Animals; Anti-Arrhythmia Agents; Benzyl Compounds; Cocaine; Electric Stimulation; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Lidocaine; Male; Methyl Ethers; Phenytoin; Piperazines; Procainamide; Propranolol; Quinidine | 1973 |
Effects of tyramine on responses to and inactivation of histamine in aortic strips.
Topics: Amine Oxidase (Copper-Containing); Amodiaquine; Animals; Aorta; Catecholamines; Chlorpheniramine; Cocaine; Diffusion; Histamine; Imidazoles; In Vitro Techniques; Iproniazid; Methylation; Muscle Contraction; Muscles; Oils; Phentolamine; Quinidine; Rabbits; Reserpine; Semicarbazides; Tranylcypromine; Tyramine | 1970 |
Apparent similarity of mechanisms of platelet adhesion and aggregation. Differentiation of these functions from clot retraction.
Topics: Amitriptyline; Aspirin; Blood Coagulation Tests; Caffeine; Chloromercuribenzoates; Chlorpromazine; Clot Retraction; Cocaine; Diphenhydramine; Ethacrynic Acid; Guanidines; Humans; Phenothiazines; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Quinacrine; Quinidine; Reserpine; Sulfinpyrazone; Sulfones; Tosyl Compounds | 1972 |
Thiamine alkyl disulfides against actions of potassium and quinidine on guinea-pig atria.
Topics: Animals; Catecholamines; Cell Membrane; Cocaine; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Muscle Contraction; Nicotine; Potassium; Quinidine; Reserpine; Strophanthins; Sulfides; Thiamine | 1969 |
Accumulation of quinidine by human blood platelets: effects on platelet ultrastructure and 5-hydroxytryptamine.
Topics: Adenosine Triphosphate; Antimetabolites; Blood Platelets; Carbon Isotopes; Cocaine; Desipramine; Dextroamphetamine; Dinitrophenols; Female; Humans; Iodoacetates; Male; Microscopy, Electron; Ouabain; Quinidine; Serotonin | 1971 |
[The effect of natural pyrones of kawaroot on isolated heart preparations and their antifibrillatory action in the intact animal].
Topics: Animals; Anti-Arrhythmia Agents; Anura; Cocaine; Electric Stimulation; Electrocardiography; Guinea Pigs; Heart; Norepinephrine; Procainamide; Pyrans; Quinidine; Strophanthins; Time Factors | 1968 |
Gas chromatography of alkaloids with polar stationary liquids.
Topics: Alkaloids; Atropine; Chromatography, Gas; Cinchona; Cocaine; Codeine; Morphine; Papaverine; Pilocarpine; Plants, Medicinal; Quinidine; Quinine; Scopolamine; Strychnine; Thebaine | 1965 |
The relationship of intracellular depolarization rates and contractility in the dog ventricle in situ: effects of positive and negative inotropic agents.
Topics: Action Potentials; Animals; Cocaine; Digoxin; Dogs; Electrophysiology; Female; Heart; Heart Ventricles; Male; Muscle Contraction; Pentobarbital; Quinidine | 1967 |
Comparison of cocaine and Na+ channel blockers on cardio-respiratory function in the rabbit.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cocaine; Dopamine Uptake Inhibitors; Electrocardiography; Female; Flecainide; Heart; Heart Rate; Lidocaine; Male; Procainamide; Quinidine; Rabbits; Respiration; Sodium Channel Blockers | 1999 |
MECHANISM OF DRUG-INDUCED VACUOLIZATION IN TISSUE CULTURE.
Topics: Acetates; Ammonium Chloride; Amnion; Animals; Atropine; Cell Division; Chick Embryo; Cocaine; Cytoplasm; Dibucaine; Ephedrine; Fibroblasts; HeLa Cells; Humans; Hydrogen-Ion Concentration; Pharmacology; Pilocarpine; Procainamide; Procaine; Quinidine; Research; Sodium; Tissue Culture Techniques; Toxicology | 1965 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |
Templating effect in DNA proximity ligation enables use of non-bioorthogonal chemistry in biological fluids.
Topics: Aptamers, Nucleotide; Benzaldehydes; Biological Assay; Buffers; Cinchona Alkaloids; Cocaine; DNA; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Nucleic Acid Conformation; Quinidine; Quinine; Sequence Analysis, DNA; Serum; Urine | 2012 |
In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17.
Topics: Cocaine; Computer Simulation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Fluoxetine; Imipramine; Molecular Docking Simulation; Molecular Dynamics Simulation; Organic Chemicals; Polymorphism, Genetic; Protein Conformation; Quinidine; Regression Analysis; Stereoisomerism; Thioridazine | 2014 |
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.
Topics: Acetamides; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Benzhydryl Compounds; Binding Sites; Carbamazepine; Cocaine; Humans; Lacosamide; Lamotrigine; Lidocaine; Molecular Docking Simulation; NAV1.4 Voltage-Gated Sodium Channel; Phenols; Phenytoin; Piperazines; Protein Binding; Pyrimidines; Quinidine; Sodium Channel Blockers; Triazines | 2017 |