cocaine and preproenkephalin

cocaine has been researched along with preproenkephalin in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	21 (39.62)	18.2507
2000's	25 (47.17)	29.6817
2010's	6 (11.32)	24.3611
2020's	1 (1.89)	2.80

Authors

Authors	Studies
Branch, AD; Kreek, MJ; Lee, SE; Unterwald, EM	1
Cohen, BM; Hyman, SE; Nguyen, TV	1
Herkenham, M; Hurd, YL	1
Daunais, JB; McGinty, JF	2
Daunais, JB; McGinty, JF; Roberts, DC	1
Kreek, MJ; Spangler, R; Unterwald, EM	1
Daunais, JB; Helton, TE; McGinty, JF	1
Caron, MG; Giros, B; Jaber, M; Jones, SR; Wightman, RM	1
Cox, BM; Donatini, A; Ferri, S; Izenwasser, S; Romualdi, P	1
Ho, A; Kreek, MJ; Maggos, CE; Spangler, R; Zhou, Y; Zlobin, A	1
Chai, L; Choi, WS; Rönnekleiv, OK	1
Ho, A; Kreek, MJ; Maggos, CE; Schlussman, SD; Spangler, R; Zhou, Y	1
Daunais, JB; Nader, MA; Porrino, LJ	1
Daunais, JB; Davies, HM; Hart, SL; Hedgecock-Rowe, A; Matasi, JJ; Porrino, LJ; Thornley, C	1
Besson, MJ; Mathieu-Kia, AM	1
Hurd, YL; Svensson, P	1
Lasoń, W; Przewłocka, B; Przewłocki, R; Turchan, J	1
Dow-Edwards, DL; Hurd, YL	1
Fagergren, P; Hurd, YL	1
Lucas, LR; McEwen, BS; Pompei, P	1
Adams, DH; Hanson, GR; Keefe, KA	1
Cox, BM; D'Addario, C; Ferri, S; Izenwasser, S; Romualdi, P	1
Alvarez Fischer, D; Ferger, B; Gross, S; Kuschinsky, K; Schäfer, MK; Weihe, E; Westermann, R	1
Ho, A; Jeanne Kreek, M; Spangler, R; Zhou, Y	1
Andersson, M; Cenci, MA; Konradi, C	1
Ho, A; Kreek, MJ; Schlussman, SD; Sora, I; Spangler, R; Uhl, GR; Yuferov, VP; Zhou, Y	1
Hurd, YL	1
Ho, A; Jeanne Kreek, M; LaForge, KS; Nyberg, F; Yuferov, V; Zhou, Y	1
Ho, A; Kreek, MJ; Schlussman, SD; Spangler, R; Zhou, Y	1
Andersson, M; Cenci, MA; Westin, JE	1
Ho, A; Kreek, MJ; Spangler, R; Zhou, Y	1
Daunais, JB; Fagergren, P; Hurd, YL; Nader, MA; Porrino, LJ; Smith, HR	1
Chavkin, C; Marton-Popovici, M; McLaughlin, JP	1
Candeletti, S; Collins, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P	1
Ho, A; Kreek, MJ; Mantsch, JR; Mathieu-Kia, AM; Yuferov, V	1
Candeletti, S; D'Addario, C; Di Benedetto, M; Feliciani, D; Izenwasser, S; Romualdi, P	1
Fagergren, P; Goiny, M; Hurd, YL; Overstreet, DH	1
Alvaro, JD; Duman, RS; Haile, C; Han, G; Hruby, VJ; Hsu, R; Nestler, EJ; Newton, SS; Taylor, JR	1
Bailey, A; Bendor, J; Ho, A; Kreek, MJ; Schlussman, SD; Yuferov, V; Zhou, Y	1
Chavkin, C; Chavkin, TA; Li, S; McLaughlin, JP; Valdez, J	1
Chavkin, C; Land, BB; Li, S; McLaughlin, JP; Pintar, JE	1
Kostowski, W; Mierzejewski, P; Przewłocki, R; Stefański, R; Zapart, G; Ziółkowska, B	1
Candeletti, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P	1
Hubert, GW; Kuhar, MJ	1
Dow-Edwards, DL; Hurd, YL; Torres-Reveron, A	1
Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK	1
Andersen, ML; Bicocchi, ES; Chagas, JR; Dalio, FM; Ferro, ES; Freua, R; Gesteira, TF; Machado, MF; Nader, HB; Oliveira, V; Perry, JC; Toledo, CA; Tufik, S; Visniauskas, B	1
Butelman, ER; Ho, A; Kreek, MJ; Schlussman, SD; Zhang, Y	1
Bastias del Carmen Candia, S; Candeletti, S; Caputi, FF; Carretta, D; Cavina, C; D'Addario, C; Di Benedetto, M; Romualdi, P	1
Cohen, A; Contet, C; George, O; Kieffer, BL; Koebel, P; Koob, GF; Kreifeldt, M; Whitfield, TW	1
Burokas, A; Gutiérrez-Cuesta, J; Kummer, S; Maldonado, R; Mancino, S; Martín-García, E	1
Graham, DP; Hamon, SC; Hillhouse, M; Kosten, TR; Lawson, WB; Ling, W; Nielsen, DA; Nielsen, EM; Rotrosen, J; Saxon, AJ; Settles-Reaves, BD; Shmueli-Blumberg, D; Shores-Wilson, K; Trivedi, MH; Walker, R	1

Trials

1 trial(s) available for cocaine and preproenkephalin

Article	Year
Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene. European journal of clinical pharmacology, 2022, Volume: 78, Issue:6 Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors	2022

Article

Year

Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.

European journal of clinical pharmacology, 2022, Volume: 78, Issue:6

Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors

2022

Other Studies

52 other study(ies) available for cocaine and preproenkephalin

Article	Year
Quantitation of preproenkephalin mRNA levels in brain regions from male Fischer rats following chronic cocaine treatment using a recently developed solution hybridization assay. Brain research. Molecular brain research, 1992, Volume: 14, Issue:3 Topics: Animals; Blotting, Northern; Brain; Cocaine; Drug Administration Schedule; Enkephalins; Injections, Intraperitoneal; Male; Organ Specificity; Protein Precursors; Rats; Rats, Inbred F344; RNA; RNA, Messenger; Time Factors	1992
Cocaine-induced changes in gene expression in rat brain. NIDA research monograph, 1990, Volume: 105 Topics: Animals; Brain; Cocaine; DNA-Binding Proteins; Early Growth Response Protein 1; Enkephalins; Gene Expression; Immediate-Early Proteins; Male; Protein Precursors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; RNA, Messenger; Signal Transduction; Synapses; Transcription Factors; Transcription, Genetic	1990
The human neostriatum shows compartmentalization of neuropeptide gene expression in dorsal and ventral regions: an in situ hybridization histochemical analysis. Neuroscience, 1995, Volume: 64, Issue:3 Topics: Acetylcholinesterase; Adolescent; Adult; Cocaine; Enkephalins; Female; Gene Expression Regulation; Humans; In Situ Hybridization; Male; Middle Aged; Neostriatum; Neurokinin A; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger; Somatostatin; Substance P; Tachykinins	1995
Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs. Brain research. Molecular brain research, 1995, Volume: 29, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Corpus Striatum; Disease Models, Animal; DNA-Binding Proteins; Drug Administration Schedule; Dynorphins; Early Growth Response Protein 1; Enkephalins; Immediate-Early Proteins; Male; Nerve Tissue Proteins; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors	1995
Short-term cocaine self administration alters striatal gene expression. Brain research bulletin, 1995, Volume: 37, Issue:5 Topics: Animals; Cocaine; Dynorphins; Enkephalins; Gene Expression; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Neostriatum; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Self Administration	1995
'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Brain research. Molecular brain research, 1993, Volume: 19, Issue:4 Topics: Animals; Brain; Caudate Nucleus; Cocaine; Drug Administration Schedule; Enkephalins; Humans; Male; Organ Specificity; Protein Precursors; Putamen; Rats; Rats, Inbred F344; RNA; RNA, Messenger; Substance-Related Disorders; Time Factors	1993
Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs. Synapse (New York, N.Y.), 1994, Volume: 18, Issue:1 Topics: Animals; Cell Nucleus; Cocaine; Dynorphins; Endorphins; Enkephalins; Gene Expression Regulation; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Neostriatum; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors	1994
Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain. Brain research. Molecular brain research, 1993, Volume: 20, Issue:3 Topics: Animals; Cocaine; Convulsants; DNA-Binding Proteins; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Immediate-Early Proteins; In Situ Hybridization; Kindling, Neurologic; Limbic System; Male; Nerve Tissue Proteins; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Seizures; Time Factors; Transcription Factors	1993
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 1996, Feb-15, Volume: 379, Issue:6566 Topics: Amphetamine; Animals; Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Gene Targeting; Locomotion; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Protein Precursors; Rats	1996
Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen. Brain research. Molecular brain research, 1996, Volume: 40, Issue:1 Topics: Animals; Caudate Nucleus; Cerebral Ventricles; Cocaine; Enkephalins; Hypothalamus; Infusions, Parenteral; Male; Protein Precursors; Putamen; Rats; Rats, Inbred F344; RNA, Messenger; Transcription, Genetic	1996
Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs. Neuroreport, 1996, Sep-02, Volume: 7, Issue:13 Topics: Analysis of Variance; Animals; Benzazepines; Brain; Carrier Proteins; Cocaine; DNA Primers; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Dynorphins; Enkephalins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Polymerase Chain Reaction; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; RNA, Messenger; Substance-Related Disorders; Sulpiride; Transcription, Genetic	1996
Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Feb-01, Volume: 17, Issue:3 Topics: Animals; Brain; Cocaine; Dynorphins; Enkephalins; Female; Gene Expression Regulation; Macaca mulatta; Narcotics; Pregnancy; Protein Precursors; RNA, Messenger	1997
Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute "binge" cocaine. Brain research. Molecular brain research, 1997, Volume: 44, Issue:1 Topics: Animals; Cocaine; Enkephalins; Male; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; RNA, Messenger; Time Factors	1997
Long-term cocaine self-administration decreases striatal preproenkephalin mRNA in rhesus monkeys. Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:3 Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; In Situ Hybridization; Macaca mulatta; Male; Protein Precursors; RNA, Messenger; Self Administration; Time Factors	1997
Alterations in behavior and opioid gene expression induced by the novel tropane analog WF-31. Brain research. Molecular brain research, 1997, Oct-15, Volume: 50, Issue:1-2 Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Fluoxetine; Gene Expression; Genome; Male; Motor Activity; Protein Precursors; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tropanes	1997
Repeated administration of cocaine, nicotine and ethanol: effects on preprodynorphin, preprotachykinin A and preproenkephalin mRNA expression in the dorsal and the ventral striatum of the rat. Brain research. Molecular brain research, 1998, Volume: 54, Issue:1 Topics: Animals; Body Weight; Cocaine; Corpus Striatum; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; In Situ Hybridization; Injections, Subcutaneous; Male; Nicotine; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins	1998
Specific reductions of striatal prodynorphin and D1 dopamine receptor messenger RNAs during cocaine abstinence. Brain research. Molecular brain research, 1998, Volume: 56, Issue:1-2 Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance Withdrawal Syndrome	1998
Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience, 1998, Volume: 85, Issue:4 Topics: Amphetamine; Animals; Autoradiography; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Endorphins; Enkephalins; In Situ Hybridization; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; RNA, Messenger	1998
Perinatal cocaine decreases the expression of prodynorphin mRNA in nucleus accumbens shell in the adult rat. Brain research. Molecular brain research, 1998, Nov-12, Volume: 62, Issue:1 Topics: Animals; Animals, Newborn; Cocaine; Enkephalins; Female; Gene Expression Regulation; In Situ Hybridization; Injections, Subcutaneous; Male; Nucleus Accumbens; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger	1998
Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine. Neuroreport, 1999, Nov-08, Volume: 10, Issue:16 Topics: Amygdala; Animals; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Estradiol; Female; Limbic System; Male; Nerve Tissue Proteins; Nucleus Accumbens; Ovariectomy; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Characteristics	1999
Correlates of deoxycorticosterone-induced salt appetite behavior and basal ganglia neurochemistry. Annals of the New York Academy of Sciences, 1999, Volume: 897 Topics: Animals; Appetite; Basal Ganglia; Carrier Proteins; Cocaine; Desoxycorticosterone; Dopamine Plasma Membrane Transport Proteins; Dynorphins; Enkephalins; Gene Expression Regulation; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Transcription, Genetic; Tyrosine 3-Monooxygenase	1999
Cocaine and methamphetamine differentially affect opioid peptide mRNA expression in the striatum. Journal of neurochemistry, 2000, Volume: 75, Issue:5 Topics: Animals; Autoradiography; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; In Situ Hybridization; Male; Methamphetamine; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger	2000
Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. European journal of pharmacology, 2001, Feb-16, Volume: 413, Issue:2-3 Topics: Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger	2001
Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 363, Issue:3 Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Dynorphins; Enkephalins; In Situ Hybridization; Locomotion; Male; Microdialysis; Neurons; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Tyrosine Transaminase	2001
Hypothalamic CRH mRNA levels are differentially modulated by repeated 'binge' cocaine with or without D(1) dopamine receptor blockade. Brain research. Molecular brain research, 2001, Oct-19, Volume: 94, Issue:1-2 Topics: Amygdala; Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamus; Male; Olfactory Bulb; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Dopamine D1; RNA, Messenger; Sulpiride	2001
cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-15, Volume: 21, Issue:24 Topics: Animals; Antiparkinson Agents; Cocaine; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Denervation; DNA; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Enkephalins; Female; Gene Expression; Levodopa; Oligonucleotides, Antisense; Oxidopamine; Parkinson Disease, Secondary; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factor AP-1	2001
Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse (New York, N.Y.), 2002, Sep-15, Volume: 45, Issue:4 Topics: Animals; Cocaine; Corpus Striatum; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Medulla Oblongata; Mice; Mice, Knockout; Pituitary-Adrenal System; Pons; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger	2002
In situ hybridization with isotopic riboprobes for detection of striatal neuropeptide mRNA expression after dopamine stimulant administration. Methods in molecular medicine, 2003, Volume: 79 Topics: Animals; Antisense Elements (Genetics); Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Humans; In Situ Hybridization; Protein Precursors; Rats; RNA Probes; RNA, Messenger	2003
"Binge" cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain. Brain research bulletin, 2003, Jan-30, Volume: 59, Issue:5 Topics: Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enkephalins; Guinea Pigs; Male; Protein Precursors; RNA, Messenger; Species Specificity	2003
Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal. Brain research, 2003, Feb-28, Volume: 964, Issue:2 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Amygdala; Animals; Blotting, Northern; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Hypothalamo-Hypophyseal System; Male; Pituitary Gland; Pituitary-Adrenal System; Pro-Opiomelanocortin; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred F344; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors	2003
Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment. The European journal of neuroscience, 2003, Volume: 17, Issue:3 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Cocaine; Denervation; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; Enzyme Inhibitors; Female; Hydroxydopamines; Immunohistochemistry; In Situ Hybridization; Levodopa; Neostriatum; Neural Pathways; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympathectomy, Chemical	2003
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Brain research. Molecular brain research, 2003, May-26, Volume: 114, Issue:1 Topics: Amygdala; Animals; Brain Stem; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Substance Withdrawal Syndrome	2003
Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. The European journal of neuroscience, 2003, Volume: 17, Issue:10 Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Macaca mulatta; Male; Protein Precursors; RNA, Messenger; Self Administration; Up-Regulation	2003
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jul-02, Volume: 23, Issue:13 Topics: Analgesia; Animals; Behavior, Animal; Cocaine; Drug Synergism; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Threshold; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Reward; Spatial Behavior; Stress, Physiological; Swimming	2003
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. Journal of molecular neuroscience : MN, 2004, Volume: 22, Issue:3 Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression Regulation; Male; p-Chloroamphetamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Time; Up-Regulation	2004
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology, 2004, Volume: 175, Issue:1 Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Extinction, Psychological; Male; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Recurrence; RNA, Messenger; Self Administration; Time Factors	2004
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS. Brain research. Molecular brain research, 2004, Aug-23, Volume: 127, Issue:1-2 Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Northern; Central Nervous System; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors	2004
Blunted response to cocaine in the Flinders hypercholinergic animal model of depression. Neuroscience, 2005, Volume: 132, Issue:4 Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Depression; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; In Situ Hybridization; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Protein Precursors; Rats; RNA, Messenger	2005
Blockade of melanocortin transmission inhibits cocaine reward. The European journal of neuroscience, 2005, Volume: 21, Issue:8 Topics: Agouti Signaling Protein; alpha-MSH; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Melanocyte-Stimulating Hormones; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nucleus Accumbens; Protein Precursors; Rats; Rats, Mutant Strains; Receptor, Melanocortin, Type 4; Reward; RNA, Messenger; Self Administration; Time Factors	2005
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex. Brain research. Molecular brain research, 2005, Jun-13, Volume: 137, Issue:1-2 Topics: Animals; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Enkephalins; Frontal Lobe; Male; Narcotic Antagonists; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors	2005
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:6 Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Enkephalins; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Social Behavior; Stress, Psychological	2006
Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Interactions; Enkephalins; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Time Factors	2006
Contingency does not contribute to the effects of cocaine self-administration on prodynorphin and proenkephalin gene expression in the rat forebrain. Brain research, 2006, Jan-19, Volume: 1069, Issue:1 Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Diagnostic Imaging; Enkephalins; Gene Expression; In Situ Hybridization; Male; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; RNA, Messenger; Self Administration	2006
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS. Neuroscience, 2007, Jan-05, Volume: 144, Issue:1 Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin	2007
Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens. Neuropeptides, 2006, Volume: 40, Issue:6 Topics: Animals; Cocaine; Enkephalins; Male; Microscopy, Fluorescence; Models, Biological; Nerve Tissue Proteins; Neurons; Neuropeptides; Nucleus Accumbens; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Substance-Related Disorders	2006
Gender differences in prodynorphin but not proenkephalin mRNA expression in the striatum of adolescent rats exposed to prenatal cocaine. Neuroscience letters, 2007, Jun-29, Volume: 421, Issue:3 Topics: Animals; Animals, Newborn; Cocaine; Corpus Striatum; Enkephalins; Female; Gene Expression Regulation, Developmental; Male; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; RNA, Messenger; Sex Characteristics	2007
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. Neuropharmacology, 2010, Volume: 58, Issue:1 Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors	2010
Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain. Biochemical and biophysical research communications, 2012, Mar-23, Volume: 419, Issue:4 Topics: Animals; Cocaine; Corpus Striatum; Enkephalins; Gene Expression; Male; Metalloendopeptidases; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger	2012
Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice. Neuropharmacology, 2012, Volume: 63, Issue:2 Topics: Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enkephalins; Male; Mice; Mice, Inbred C57BL; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome	2012
Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry, 2014, Mar-03, Volume: 49 Topics: Animals; Cocaine; Corpus Striatum; Dynorphins; Enkephalins; Epigenesis, Genetic; Gene Expression Regulation; Histones; Male; Nociceptin; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Receptors, Opioid; Receptors, Opioid, kappa	2014
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PloS one, 2014, Volume: 9, Issue:5 Topics: Analysis of Variance; Animals; Anxiety; Cocaine; Dependovirus; Depression; Enkephalins; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Vectors; In Situ Hybridization; Locomotion; Maze Learning; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; RNA, Small Interfering	2014
Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:13 Topics: Analysis of Variance; Anesthetics, Local; Animals; Cocaine; Conditioning, Operant; Cues; Drug-Seeking Behavior; Enkephalins; Gene Expression Regulation; Mice; Mice, Knockout; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement Schedule; Reinforcement, Psychology; Self Administration	2014