cocaine has been researched along with piperidines in 253 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (12.25) | 18.7374 |
| 1990's | 36 (14.23) | 18.2507 |
| 2000's | 96 (37.94) | 29.6817 |
| 2010's | 84 (33.20) | 24.3611 |
| 2020's | 6 (2.37) | 2.80 |
| Authors | Studies |
|---|---|
| Iversen, SD; Morgan, MJ; Robbins, TW; Sahakian, BJ | 1 |
| van Zwieten, PA | 1 |
| Harms, J; Woodward, JJ | 1 |
| Akiyama, K; Otsuki, S; Tsuchida, K; Ujike, H | 1 |
| Abraham, P; Carroll, FI; Cline, EJ; Dannals, RF; Kuhar, MJ; Lewin, AH; Ricaurte, GA; Scheffel, U | 1 |
| Gessa, GL; Hmaidan, Y; Rossetti, ZL | 1 |
| Akbari, HM; Azmitia, EC; Kramer, HK; Spear, LP; Whitaker-Azmitia, PM | 1 |
| Cizmárik, J; Medvecký, R; Minh, DN; Racanská, E | 1 |
| Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Philip, A; Rahman, MA | 1 |
| Duckles, SP; Massamiri, T | 2 |
| Béderová, E; Pisková, L; Racanský, V | 1 |
| Atkinson, J; Goudie, AJ; West, CR | 1 |
| Cohen, RA | 1 |
| Kilbinger, H; Pfeuffer-Friederich, I | 1 |
| Green, KL | 1 |
| Hoffmeister, F; Wuttke, W | 1 |
| Lechat, P; Streichenberger, G | 1 |
| Aceto, MD; Fitzgerald, JJ; Pearl, J | 1 |
| Fog, R | 1 |
| Chaplin, E; Eckhardt, SB; Hite, G; Maxwell, RE; Soares, JR | 1 |
| Carr, LA; Moore, KE | 1 |
| Hitomi, M; Schuster, CR; Wilson, MC | 1 |
| Schuster, CR; Wilson, MC | 1 |
| Hashimoto, H; Kasuya, Y | 1 |
| Hoffmeister, F; Schlichting, UU | 1 |
| Nigam, IC; Radecka, C | 1 |
| af Ekenstam, B | 1 |
| Grewal, RS; Kaul, CL | 1 |
| Beninger, RJ; Hanson, DR; Phillips, AG | 1 |
| Ennis, C; Gaskin, M; Robbins, TW; Watson, BA | 1 |
| Piercey, M; Roberts, DC; Smith, A | 1 |
| Clark, D; Exner, M; Furmidge, LJ; Sonesson, C; Svensson, K | 1 |
| Clapham, J; Kilpatrick, GJ | 1 |
| Dutta, AK; Madras, BK; Meltzer, PC; Reith, ME | 1 |
| de Costa, BR; Eldefrawi, ME; He, X; Mattson, MV; Raymon, LP | 1 |
| Ferkany, J; Hickey, P; Katz, JL; Menkel, M; Pontecorvo, M; Terry, P; Witkin, JM | 1 |
| Callahan, PM; Cunningham, KA | 1 |
| Järbe, TU | 1 |
| Ahtee, L; Kivastik, T; Piepponen, TP; Vuorikallas, K; Zharkovsky, A | 1 |
| Kamenka, JM; Kleven, MS; Koek, W; Prinssen, EP; Vignon, J | 1 |
| Arnaud, M; Kamenka, JM; Martin-Fardon, R; Privat, A; Rousseau, E; Vignon, J | 1 |
| Bourin, M; Hascoet, M; Lombet, A; Payeur, R; Peglion, JL | 1 |
| Galloway, MP; Koch, S; Piercey, MF; Svensson, KA | 1 |
| Avor, KS; Basmadjian, GP; Pouw, B; Seale, TW; Singh, S | 1 |
| Efange, SM; Kamath, AP; Khare, AB; Kung, MP; Mach, RH; Parsons, SM | 1 |
| Dashevsky, BA; Frank, RA; Grocki, S; Kehne, JH; Schmidt, CJ; Sorensen, SM; Tsibulsky, VL | 1 |
| Coffey, LL; Dutta, AK; Reith, ME | 1 |
| Chaperon, F; Puech, AJ; Soubrié, P; Thiébot, MH | 1 |
| Araldi, GL; Boja, J; Flippen-Anderson, JL; George, C; Johnson, KM; Kozikowski, AP; Meil, WM; Saiah, E | 1 |
| Dutta, AK; Reith, ME; Xu, C | 1 |
| Hagan, J; Hatcher, JP; Lewis, VA; Reavill, C; Sanger, GJ | 1 |
| Misawa, M; Mori, T; Onodera, K; Suzuki, T; Tsuji, M | 1 |
| Heron-Maxwell, CL; O'Neill, MF; Shaw, G | 1 |
| Cunningham, KA; McMahon, LR | 2 |
| Akinshola, BE; Chakrabarti, A; Onaivi, ES | 1 |
| Babich, J; Hoepping, A; Johnson, KM; Kozikowski, AP; Machill, S; Zubieta, JA | 1 |
| Battaglia, G; Cabrera-Vera, TM; Van De Kar, LD | 1 |
| Bandyopadhyay, BC; Deschaux, O; Enyedy, IJ; Johnson, KM; Kozikowski, AP; Sakamuri, S; Tella, SR; Wang, S; Zaman, WA | 1 |
| Balster, RL; Beardsley, PM; Bespalov, AY; Dravolina, OA; Zvartau, EE | 1 |
| Deschaux, O; Flippen-Anderson, JL; Johnson, KM; Kozikowski, AP; Tamiz, AP; Tella, S; Zhang, J; Zhang, M | 1 |
| Goldberg, SR; Munzar, P; Tanda, G | 1 |
| Davidson, C; Ellinwood, EH; King, GR; Lee, TH | 1 |
| Cossu, G; Fattore, L; Fratta, W; Martellotta, MC; Mascia, MS | 1 |
| Dutta, AK; Madras, BK; Reith, ME | 1 |
| Audenaert, K; D'Asseler, Y; Dierckx, R; Dumont, F; Koole, M; Van Laere, K; Versijpt, J | 1 |
| Enyedy, IJ; Johnson, KM; Kozikowski, AP; Sakamuri, S; Wang, S; Zaman, WA | 1 |
| Beardsley, PM; Dutta, AK; Fei, XS; Newman, JL; Reith, ME | 1 |
| Dutta, AK; Gaffaney, JD; Lever, JR; Reith, ME; Vaughan, RA | 1 |
| Bandyopadhyay, BC; Flippen-Anderson, JL; Johnson, KM; Kozikowski, AP; Tamiz, AP; Tella, S; Wang, CZ; Zhang, J; Zhang, M | 1 |
| Johnson, KJ; Kozikowski, AP; Petukhov, PA; Tella, SR; Zhang, M | 1 |
| Davis, MC; Dutta, AK; Reith, ME | 1 |
| Cunningham, KA; Filip, M; McMahon, LR | 1 |
| Piomelli, D | 1 |
| Crombag, H; De Vries, TJ; Dieben, J; Homberg, JR; Schoffelmeer, AN; Schuurman, K; Shaham, Y; Vanderschuren, LJ | 1 |
| Deroche-Gamonet, V; Le Moal, M; Piazza, PV; Soubrié, P | 1 |
| Beardsley, PM; Cook, CD; Davis, MC; Dutta, AK; Fei, XS; Reith, ME | 1 |
| Balster, RL; Beardsley, PM; Dance, ME; Munzar, P | 1 |
| Angulo, JA; Noailles, PA | 1 |
| Johnson, KM; Kozikowski, AP; Petukhov, PA; Tella, SR; Wang, CZ; Ye, YP; Zhang, J | 1 |
| Mori, T; Narita, M; Onodera, K; Suzuki, T | 1 |
| Kozikowski, A; Ordway, GA; Paul, IA; Petukhov, P; Ranaldi, R; Wang, Z; Woolverton, WL | 1 |
| Winger, GD; Woods, JH | 1 |
| Fletcher, PJ; Grottick, AJ; Higgins, GA | 1 |
| Carroll, FI; Khaliq, I; Lutfy, K; Maidment, NT | 1 |
| Choi, SW; Elmaleh, DR; Fischman, AJ; Hanson, RN; Shoup, TM | 1 |
| Cashman, JR; Fandrick, K; Feng, X; Janowsky, A; Johnson, R | 1 |
| Katz, JL; Panlilio, LV; Pickens, RW; Schindler, CW | 1 |
| Beardsley, PM; Cook, C; Davis, M; Dutta, AK; George, C; Ghorai, SK; Reith, ME; Venkataraman, SK | 1 |
| Araldi, GL; Balster, RL; Bandyopadhyay, BC; Beardsley, PM; Carmona, G; Deschaux, O; Johnson, KM; Kozikowski, AP; Munzar, P; Smith, MP; Tella, SR | 1 |
| Browman, KE; Curzon, P; Decker, MW; Fox, GB; Hancock, AA; Komater, VA | 1 |
| Hikida, T; Kitabatake, Y; Nakanishi, S; Pastan, I | 1 |
| Carroll, FI | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Saria, A; Sturm, K; Wakonigg, G; Zernig, G | 1 |
| Forman, LJ | 1 |
| BLASCHKO, H; HIMMS, JM; STROMBLAD, BC | 1 |
| SMITH, CB | 3 |
| BOFF, E; SCHECKEL, CL | 1 |
| LUDDEN, CT; PORTER, CC; STAVORSKI, JM; STONE, CA; TOTARO, JA | 1 |
| JACOBSON, J; URSILLO, RC | 1 |
| HAHN, RA; LAPIDUS, JB; NELSON, JW; TYE, A | 1 |
| BOHNER, B; CHEN, G; ENSOR, CR | 1 |
| France, CP; McMahon, LR | 1 |
| Czoty, PW; Gage, HD; Morgan, D; Nader, MA; Shannon, EE | 1 |
| Burton, P; Mechoulam, R; Parker, LA; Sorge, RE; Yakiwchuk, C | 1 |
| Johnson, KM; Kozikowski, AP; Petukhov, PA; Wang, CZ; Ye, YP; Zhang, J | 1 |
| Gessa, GL; Melis, M; Muntoni, AL; Perra, S; Pillolla, G; Pistis, M | 1 |
| Cossu, G; Deiana, S; Fadda, P; Fattore, L; Fratta, W; Spano, MS | 1 |
| Beardsley, PM; Cook, CD; Deschamps, J; Dutta, AK; Ghorai, SK; Kolhatkar, R; Reith, ME | 1 |
| He, R; Johnson, KM; Kozikowski, AP; Ye, Y; Zhou, J | 1 |
| Kozikowski, AP; Petukhov, PA; Yuan, H | 1 |
| Burbach, JP; Gerrits, MA; Hoogveld, E; Lesscher, HM; van Ree, JM | 1 |
| Chen, N; Dutta, AK; Maiti, S; Reith, ME; Zhen, J | 1 |
| Ledent, C; Maldonado, R; Mendizábal, V; Parmentier, M; Robledo, P; Soria, G; Touriño, C; Valverde, O | 1 |
| Brabant, C; Charlier, Y; Quertemont, E; Tirelli, E | 1 |
| Boos, TL; Calhoun, WJ; Dersch, CM; Greiner, E; Jacobson, AE; Nightingale, B; Rice, KC; Rothman, RB | 1 |
| Goldberg, SR; Justinova, Z; Redhi, GH; Solinas, M; Tanda, G | 1 |
| Filip, M; Frankowska, M; Göthert, M; Przegaliński, E | 1 |
| Caillé, S; Parsons, LH | 1 |
| Beardsley, PM; Carroll, FI; Howard, JL; Shelton, KL | 1 |
| Cunningham, KA; Frankel, PS; McMahon, LR; Szucs, RP | 1 |
| Nuwayhid, SJ; Werling, LL | 1 |
| Galuska, CM; Hursh, SR; Winger, G; Woods, JH | 1 |
| Barros, M; De Souza Silva, MA; Huston, JP; Jocham, G; Maior, RS; Mello, EL; Müller, CP; Tomaz, C | 1 |
| Brabant, C; Quertemont, E; Tirelli, E | 1 |
| Al Tikriti, M; Baldessarini, RJ; Baldwin, RM; Bois, F; Innis, RB; Kula, NS; Tamagnan, GD | 1 |
| Gardner, EL; Gilbert, JG; Li, X; Pak, AC; Peng, XQ; Xi, ZX | 1 |
| McMahon, LR | 1 |
| de Souza Silva, MA; Huston, JP; Jocham, G; Kart-Teke, E; Lezoch, K; Müller, CP | 1 |
| Daws, LC; Frazer, A; Giuffrida, A; Gould, GG; Owens, WA; Price, DA; Roberts, JL | 1 |
| Fujiwara, A; Hironaka, N; Iino, M; Sasaki, M; Wakasa, Y; Yanagita, T | 1 |
| Battista, N; Bernardi, G; Centonze, D; De Chiara, V; Maccarrone, M; Mercuri, NB; Prosperetti, C; Rossi, S; Usiello, A | 1 |
| Constales, C; Miller, DK; Putnam, WC; Rodvelt, KR | 1 |
| Corbillé, AG; Girault, JA; Hervé, D; Ledent, C; Lutz, B; Marsicano, G; Valjent, E | 1 |
| Wade-Galuska, T; Winger, G; Woods, JH | 1 |
| Dillon, C; Gardner, EL; Gilbert, J; Li, X; Pak, AC; Peng, XQ; Spiller, K; Xi, ZX | 1 |
| Panlilio, LV; Schindler, CW; Thorndike, EB | 1 |
| Carroll, FI; Tallarida, R; Vasterling, T; Wang, Z; Woolverton, WL | 1 |
| Berkowitz, JS; Caine, SB; Gabriel, KI; Gold, LH; Koob, GF; Thomsen, M; Tonegawa, S; Xu, M; Zhang, J | 1 |
| French, ED; Gerdeman, GL; Schechter, JB | 1 |
| Hamid, A; Lutfy, K; Marquez, P; Nguyen, AT | 1 |
| Nomikos, GG; Panagis, G; Stamatopoulou, F; Vlachou, S | 1 |
| Crespo, JA; Saria, A; Stöckl, P; Zernig, G; Zorn, K | 1 |
| Cherng, CG; Chiang, CY; Fan, HY; Kao, GS; Lai, YT; Yu, L | 1 |
| Tallarida, R; Vasterling, T; Wang, Z; Woolverton, WL | 1 |
| De Vries, TJ; Pattij, T; Schoffelmeer, AN; Wiskerke, J | 1 |
| Alleva, L; Brabant, C; Grisar, T; Jatlow, P; Lakaye, B; Lin, JS; Ohtsu, H; Picciotto, MR; Quertemont, E; Tirelli, E | 1 |
| Gardner, EL; Hoffman, AF; Li, X; Lupica, CR; Peng, XQ; Xi, ZX | 1 |
| Hillard, CJ; Liu, QS; Pan, B | 1 |
| Baumann, MH; Blough, BE; Mello, NK; Negus, SS; Rothman, RB | 1 |
| Baptista, MA; Dayas, CV; Martin-Fardon, R; Weiss, F | 1 |
| Cunningham, KA; Fox, RG; Nic Dhonnchadha, BA; Rice, KC; Stutz, SJ | 1 |
| Edwards, S; George, O; Koob, GF; Orio, L; Parsons, LH | 1 |
| Batman, AM; Beardsley, PM; Dutta, AK; Kharkar, PS; Reith, ME; Zhen, J | 1 |
| Schumann, J; Yaka, R | 1 |
| Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK | 1 |
| Dykstra, LA; Rosenberg, M; Walker, EA; Ward, SJ | 1 |
| Walker, EA; Ward, SJ | 1 |
| DeSouza, C; Grasing, K; Mathur, D; Newton, TF | 1 |
| Colado, MI; Izco, M; Lopez-Jimenez, A; Lopez-Moreno, JA; Mayado, A; O'Shea, E; Peraile, I; Torres, E | 1 |
| Fernandez-Espejo, E; Moratalla, R; Ortiz, O; Ramiro-Fuentes, S | 1 |
| Buccafusco, JJ; Hall, BJ; Pearson, LS | 1 |
| Czoty, PW; Gage, HD; Hamilton, LR; Nader, MA | 1 |
| Angelucci, F; Bernardi, G; Caltagirone, C; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Maccarrone, M; Mataluni, G; Musella, A; Napolitano, F; Rossi, S; Sacchetti, L; Usiello, A | 1 |
| Bruckmann, W; De Vry, J; Rutten, K; Tzschentke, TM | 1 |
| Cooper, ZD; Shi, YG; Woods, JH | 1 |
| Lominac, KD; McCreary, AC; McIver, G; Szumlinski, KK; Valdivia, PN; Zayara, AE | 1 |
| Batman, AM; Beardsley, PM; Dutta, AK; Reith, ME | 1 |
| Brunner, D; Caldarone, BJ; Ghavami, A; Korte, SM; Korte-Bouws, GA; Kozikowski, AP; Olivier, B; Paterson, NE; Prins, J; Westphal, KG; Zhou, J | 1 |
| Jiang, W; Liu, JF; Lu, L; Wang, XY; Xue, YX; Yu, LL; Zhou, SJ | 1 |
| Castelli, MP; Ennas, MG; Lecca, S; Luchicchi, A; Melis, M; Muntoni, AL; Pistis, M | 1 |
| Besnard, A; Caboche, J; Girault, JA; Heck, N; Hervé, D; Pagès, C; Pascoli, V; Vanhoutte, P | 1 |
| Brasnjo, G; Grueter, BA; Malenka, RC | 1 |
| Neisewander, JL; Pentkowski, NS; Pockros, LA; Swinford, SE | 1 |
| Fernandez-Espejo, E; Ramiro-Fuentes, S | 1 |
| Freeman, KB; Woolverton, WL | 1 |
| Banala, A; Blaylock, BL; Gould, RW; Grundt, P; Luedtke, RR; Nader, MA; Newman, AH | 1 |
| Fletcher, PJ; Higgins, GA; Noble, K; Rizos, Z | 1 |
| Coop, A; Fantegrossi, WE; Katz, JL; Li, SM; Matsumoto, RR | 1 |
| Anastasio, NC; Bubar, MJ; Cunningham, KA; Fox, RG; Moeller, FG; Rice, KC; Stoffel, EC | 1 |
| Galuska, CM; Wade-Galuska, T; Winger, G | 1 |
| Brown, TE; Dietz, D; Dong, Y; Ferguson, D; Huang, YH; Ishikawa, M; Kalivas, PW; Lee, BR; Lin, Y; Mu, P; Nestler, EJ; Ohnishi, YN; Schlüter, OM; Shen, H; Sorg, BA; Suska, A; Zukin, RS | 1 |
| Hall, A; Koffarnus, MN; Winger, G | 1 |
| Boonstra, R; Erb, S; Kupferschmidt, DA; Newman, AE | 1 |
| Liu, QS; Pan, B; Sun, D; Zhong, P | 1 |
| Cao, J; Hiranita, T; Katz, JL; Kohut, SJ; Kopajtic, T; Newman, AH; Soto, PL; Tanda, G | 1 |
| Hillard, CJ; Kreutter, M; Lacourt, M; Mantsch, JR; Stroh, G; Vaughn, LK; Vranjkovic, O | 1 |
| Ford, KA; Loweth, JA; Marinelli, M; McCutcheon, JE; Tseng, KY; Wolf, ME | 1 |
| Davidson, C; Ramsey, J | 1 |
| Lecca, S; Luchicchi, A; Melis, M; Muntoni, AL; Pistis, M | 1 |
| Grasing, K; He, S; Yang, Y | 1 |
| Carroll, FI; McMahon, LR; Schulze, DR | 1 |
| España, RA; Ferris, MJ; Harp, J; Jones, SR; Oleson, EB | 1 |
| Erb, S; Klas, PG; Kupferschmidt, DA | 1 |
| Buděšínský, M; Dračínský, M; Pohl, R; Potmischil, F; Slavětínská, L; Vaněk, V | 1 |
| Conway, SM; Neisewander, JL; Pentkowski, NS; Pockros, LA; Ullman, TE; Zwick, KR | 1 |
| Dankoski, EC; Fish, EW; Han, JE; Hodge, CW; Krouse, MC; Malanga, CJ; Philpot, BD; Riday, TT; Walsh, PL; Wightman, RM | 1 |
| Burton, CL; Diwan, M; Fletcher, PJ; Nobrega, JN; Rizos, Z | 1 |
| Khroyan, TV; Stauber, G; Toll, L; Vazquez-DeRose, J; Xie, XS; Zaveri, NT | 1 |
| Barrot, M; Bockaert, J; Charnay, Y; Compan, V; Dusticier, N; Jean, A; Laurent, L; Neve, R; Nieoullon, A | 1 |
| Chorvat, RJ | 1 |
| Chun, LE; Green, JL; Katz, JL; Mereu, M; Tanda, G; Thomas, AM; Tronci, V | 1 |
| Bi, GH; Gardner, EL; Keck, TM; Newman, AH; Srivastava, R; Wang, XF; Xi, ZX; Yang, HJ; Zhang, HY; Zou, MF | 1 |
| Baladi, MG; France, CP; Newman, AH | 1 |
| Abbas, Z; Arvanitogiannis, A; Bernstein, DL; Cheer, JF; Gentry, RN; Hernandez, G; Oleson, EB | 1 |
| Cheng, K; Heilig, M; King, CE; Rice, KC; Schank, JR; Schroeder, JP; Sun, H; Weinshenker, D | 1 |
| Barros, M; Cagni, P; de Jesus, AG; Melo, GC | 1 |
| Freeman, KB; Naylor, JE; Prisinzano, TE; Woolverton, WL | 1 |
| Lagorio, CH; Winger, G | 1 |
| Bentley, TA; France, CP; Grenier, AE; Serafine, KM | 1 |
| Freeman, KB; Huskinson, SL; Woolverton, WL | 1 |
| Itzhak, Y; Liddie, S | 1 |
| Hu, SS; Liu, YW; Yu, L | 1 |
| Baldaia, MA; Berro, LF; Frussa-Filho, R; Hollais, AW; Longo, BM; Marinho, EA; Oliveira-Lima, AJ; Patti, CL; Santos, R; Takatsu-Coleman, AL; Wuo-Silva, R; Yokoyama, TS | 1 |
| Hu, Y; Liu, QS; Liu, Y; Wang, T; Zhao, YP; Zhong, P | 1 |
| Baker, DA; Doncheck, EM; Ganzman, GS; Hillard, CJ; Mantsch, JR; McReynolds, JR; Vranjkovic, O | 1 |
| Cox, CD; Gall, CM; Geschwind, DH; Karsten, CA; Lee, D; Peñagarikano, O; Piomelli, D; Wei, D | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK | 1 |
| Clancy, PT; Lim, YW; Muelbl, MJ; Nawarawong, NN; Nettesheim, CE; Olsen, CM | 1 |
| Martinez, LA; Meisel, RL; Mermelstein, PG; Peterson, BM | 1 |
| Coggiano, M; Hiranita, T; Katz, JL; Mereu, M; Quarterman, JC; Tanda, G | 1 |
| DeSouza, C; Grasing, K; Mathur, D; Moody, DE; Newton, TF; Sturgill, M | 1 |
| Jones, SR; McGinnis, MM; Siciliano, CA | 1 |
| Alleva, L; Brabant, C; Charlier, Y; Navacerrada, MES; Tirelli, E | 1 |
| DePoy, LM; Gourley, SL; Marvar, PJ; Zimmermann, KS | 1 |
| Antoniou, K; Delis, F; Goldberg, SR; Justinova, Z; Nomikos, GG; Polissidis, A; Poulia, N | 1 |
| Baldaia, MA; Berro, LF; da Silva, RW; Frussa-Filho, R; Hollais, AW; Longo, BM; Marinho, EAV; Oliveira-Lima, AJ; Ribeiro, LTC; Santos-Baldaia, R; Talhati, F; Yokoyama, TS | 1 |
| Avvisati, R; Badiani, A; Malavasi, E; Marinelli, S; Meringolo, M; Stendardo, E | 1 |
| Barrett, AC; Butler, P; Caine, SB; Negus, SS; Thomsen, M | 1 |
| Ciccocioppo, R; de Guglielmo, G; Journigan, VB; Kallupi, M; Shen, Q; Yasuda, D; Zaveri, NT | 1 |
| Barron, LM; DeBaker, MC; Doncheck, EM; Frick, KM; Hillard, CJ; Liddiard, GT; Mantsch, JR; Tuscher, JJ; Urbanik, LA | 1 |
| Abraham, D; Barak, LS; Boone, P; Caron, MG; Mao, L; Pack, TF; Slosky, LM; Toth, K; Urs, NM | 1 |
| Baker, DA; Cravatt, BF; Doncheck, EM; Graf, EN; Hillard, CJ; Li, Y; Liu, QS; Mantsch, JR; McReynolds, JR; Ogasawara, D; Vranjkovic, O | 1 |
| Hearing, MC; Huffington, ED; Ingebretson, AE; Thomas, MJ | 1 |
| Belin, D; Belin-Rauscent, A; Everitt, BJ; Hermine, O; Lacoste, J; Moussy, A | 1 |
| da Silveira, VT; de Oliveira, AC; Del Bel, EA; Issy, AC; Matosinhos, AL; Moreira, FA; Röpke, J | 1 |
| Adams, WK; Bannerman, DM; Barkus, C; Churchill, GC; Cowen, PJ; Ferland, JN; Rogers, RD; Sharp, T; Winstanley, CA | 1 |
| Brabant, C; Huyts, B; Tirelli, E | 1 |
| Branco, RC; Foster, SL; Manvich, DF; Miller, GW; Newman, AH; Paladini, CA; Petko, AK; Porter-Stransky, KA; Stout, KA; Weinshenker, D | 1 |
| Asp, AJ; Benneyworth, MA; Ebner, SR; Hearing, MC; Ingebretson, AE; Larson, EB; Madayag, A; Schmidt, CE; Silvis, KA; Thomas, MJ | 1 |
| Baumann, MH; Humburg, BA; Jordan, CJ; Newman, AH; Schindler, CW; Shaik, AB; Thorndike, EB; Xi, ZX | 1 |
| Barnes, M; Cippitelli, A; Toll, L; Zaveri, NT | 1 |
| Borroto-Escuela, DO; Filip, M; Fuxe, K; Romero-Fernandez, W; Suder, A; Wydra, K; Zhou, Z | 1 |
| Aguiar, DC; Asth, L; Briânis, RC; Iglesias, LP; Marçal, AP; Moreira, FA; Soares, NP | 1 |
| Amiad, L; Azriel, M; Bingor, A; Yaka, R | 1 |
| Caffino, L; Filip, M; Fumagalli, F; Sanak, M; Smaga, I; Suder, A; Wydra, K | 1 |
| Alalawi, A; Aldhafiri, A; Dodu, JC; Soderstrom, K | 1 |
| Cahill, L; Gold, PE; Wenk, GL | 1 |
| Elvert, R; Haschke, G; Herling, AW; Kilp, S; Kramer, W | 1 |
3 review(s) available for cocaine and piperidines
| Article | Year |
|---|---|
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Topics: Animals; Biogenic Monoamines; Biological Transport; Carrier Proteins; Cocaine; Fluorescent Dyes; Humans; Isoquinolines; Ligands; Morphinans; Narcotic Antagonists; Piperidines; Protein Binding; Radioisotopes; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders | 2003 |
The role of CB1 receptors in psychostimulant addiction.
Topics: Amphetamine-Related Disorders; Amphetamines; Animals; Association Learning; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Humans; Mice; Motivation; Neuronal Plasticity; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2008 |
Peripherally restricted CB1 receptor blockers.
Topics: Animals; Brain; Cocaine; Drug Discovery; Humans; Liver Diseases; Metabolic Diseases; Morpholines; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfonamides | 2013 |
3 trial(s) available for cocaine and piperidines
| Article | Year |
|---|---|
Morphine- and cocaine-induced conditioned place preference: effects of quinpirole and preclamol.
Topics: Animals; Cocaine; Conditioning, Operant; Dopamine Agonists; Male; Morphine; Narcotics; Piperidines; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals.
Topics: Behavior, Addictive; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indans; Infusions, Intravenous; Male; Middle Aged; Piperidines; Reinforcement, Psychology | 2010 |
Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil.
Topics: Administration, Oral; Adult; Biological Availability; Cardiovascular System; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Premedication; Treatment Outcome | 2016 |
247 other study(ies) available for cocaine and piperidines
| Article | Year |
|---|---|
The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats.
Topics: Amphetamine; Animals; Apomorphine; Brain Chemistry; Cocaine; Dopamine; Dose-Response Relationship, Drug; Female; Humans; Locomotion; Motor Activity; Norepinephrine; Piperidines; Rats; Social Isolation; Stereotyped Behavior | 1975 |
Interaction between centrally acting hypotensive drugs and tricyclic antidepressants.
Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Cats; Clonidine; Cocaine; Desipramine; Dioxanes; Drug Interactions; Ephedrine; Female; Male; Methyldopa; Piperidines; Reserpine | 1975 |
The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cocaine; Dopamine; Male; N-Methylaspartate; Norepinephrine; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Supersensitivity of sigma receptors after repeated administration of cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Agents; Drug Administration Schedule; Injections, Intraperitoneal; Male; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1992 |
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
Topics: Animals; Biological Transport, Active; Cocaine; Fenfluramine; Histocytochemistry; Indicators and Reagents; Iodine Radioisotopes; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tomography, Emission-Computed, Single-Photon | 1992 |
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats.
Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Ethanol; Male; Morphine; Naloxone; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1992 |
Prenatal cocaine exposure disrupts the development of the serotonergic system.
Topics: Animals; Animals, Newborn; Cocaine; Embryonic and Fetal Development; Female; Immunohistochemistry; Maternal-Fetal Exchange; Nerve Fibers; Neurons; Paroxetine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1992 |
Study of local anaesthetics. Part 98(3): Preparation and local anaesthetic activity of 4-alkylpiperazinoethyl esters of o-heptyloxyphenylcarbamic acid.
Topics: Anesthetics, Local; Animals; Carbamates; Cocaine; Guinea Pigs; Lethal Dose 50; Mice; Piperazines; Piperidines; Procaine | 1992 |
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
Topics: Animals; Benzamides; Binding, Competitive; Brain Stem; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Thiocyanates | 1991 |
Multiple vascular effects of sigma and PCP ligands: inhibition of amine uptake and contractile responses.
Topics: Animals; Cocaine; Desoxycorticosterone; Haloperidol; Male; Norepinephrine; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Serotonin; Vasoconstriction | 1990 |
Multiple sites of action of (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3PPP) in blood vessels.
Topics: Animals; Arteries; Cocaine; Desoxycorticosterone; Ear; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulpiride; Tail | 1990 |
The influence of local anesthetics on the gel-liquid crystal phase transition in model dipalmitoylphosphatidylcholine membranes.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Anesthetics, Local; Cocaine; Dibucaine; Electron Spin Resonance Spectroscopy; Gels; Lidocaine; Lipid Bilayers; Microscopy, Polarization; Physical Phenomena; Physics; Piperidines; Tetracaine | 1988 |
Discriminative properties of the psychostimulant dl-cathinone in a two lever operant task. Lack of evidence for dopaminergic mediation.
Topics: Alkaloids; Animals; Brain; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Cues; Dextroamphetamine; Discrimination Learning; Female; Generalization, Stimulus; Methylphenidate; Phenylpropanolamine; Piperidines; Rats | 1986 |
Contractions of isolated canine coronary arteries resistant to S2-serotonergic blockade.
Topics: Angiotensin II; Animals; Blood Platelets; Cocaine; Coronary Vessels; Cyproheptadine; Dibenzothiepins; Dinoprost; Dogs; Drug Resistance; Endothelium; Femoral Artery; In Vitro Techniques; Ketanserin; Methiothepin; Piperidines; Potassium; Prostaglandins F; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sympathetic Nervous System; Vasoconstriction | 1986 |
Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus.
Topics: Acetylcholine; Animals; Binding, Competitive; Cocaine; Electric Stimulation; Female; Guinea Pigs; Ketanserin; Male; Methiothepin; Methysergide; Metoclopramide; Muscle Contraction; Myenteric Plexus; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropanes | 1985 |
Role of endogenous catecholamines in the anti-inflammatory activity of alpha-adrenoceptor blocking agents.
Topics: Adrenal Glands; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Capillary Permeability; Catecholamines; Cocaine; Desipramine; Dioxins; Epinephrine; Female; Methyltyrosines; Mice; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Phentolamine; Piperidines; Rats; Serum Albumin; Uterus; Yohimbine | 1974 |
Negative reinforcing properties of morphine-antagonists in naive rhesus monkeys.
Topics: Animals; Avoidance Learning; Cocaine; Codeine; Conditioning, Classical; Cyclazocine; Escape Reaction; Female; Haplorhini; Macaca; Male; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Pentazocine; Piperidines; Propionates; Pyridines; Reinforcement, Psychology | 1973 |
[Application of sleep induced in the rat by sudden change in the environmental temperature to the study of antagonism between neurostimulants and hypnotics].
Topics: Amphetamine; Animals; Antidepressive Agents; Bemegride; Caffeine; Central Nervous System; Chloral Hydrate; Cocaine; Drug Antagonism; Environment; Hypnotics and Sedatives; Pentobarbital; Pentylenetetrazole; Piperidines; Pregnanediones; Rats; Secobarbital; Sleep; Strychnine; Temperature; Thiazoles | 1967 |
Stimulant drugs and temporary increases in avoidance responding.
Topics: Animals; Avoidance Learning; Cocaine; Escape Reaction; Male; Motor Activity; Piperidines; Rats; Time Factors | 1968 |
Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain; Caffeine; Central Nervous System; Cocaine; Lysergic Acid Diethylamide; Male; Methamphetamine; Methylphenidate; Nikethamide; Pemoline; Phenmetrazine; Piperidines; Rats | 1969 |
Conformational similarities between molecular models of phenethylamine and of potent inhibitors of the uptake of tritiated norepinephrine by adrenergic nerves in rabbit aorta.
Topics: Animals; Antidepressive Agents; Aorta; Chemical Phenomena; Chemistry; Cocaine; Desipramine; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylphenidate; Models, Structural; Norepinephrine; Nortriptyline; Phenethylamines; Piperidines; Rabbits; Sensory Receptor Cells; Sympathetic Nervous System; Tritium; Tyramine | 1970 |
Release of norepinephrine and normetanephrine from cat brain by central nervous system stimulants.
Topics: Amphetamine; Animals; Brain; Caffeine; Cats; Chlorine; Cocaine; Dextroamphetamine; Ephedrine; Methylphenidate; Norepinephrine; Normetanephrine; Piperidines; Tritium | 1970 |
Psychomotor stimulant self administration as a function of dosage per injection in the rhesus monkey.
Topics: Animals; Behavior, Animal; Cocaine; Haplorhini; Injections, Intravenous; Macaca; Methylphenidate; Phenmetrazine; Piperidines; Reinforcement, Psychology; Self Medication; Self Stimulation | 1971 |
The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey.
Topics: Amphetamine; Animals; Behavior, Animal; Chlorpromazine; Cocaine; Drug Antagonism; Humans; Macaca; Methylphenidate; Phenmetrazine; Piperidines; Self Stimulation; Stimulation, Chemical; Substance-Related Disorders | 1972 |
Potentiation of cardiovascular effects of catecholamines by a diphenylalkanolamine.
Topics: Animals; Blood Pressure; Butanols; Catecholamines; Cats; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Female; Heart Rate; Hemodynamics; Isoproterenol; Male; Nictitating Membrane; Norepinephrine; Piperidines; Respiration; Time Factors; Tritium | 1974 |
Reinforcing properties of some opiates and opioids in rhesus monkeys with histories of cocaine and codeine self-administration.
Topics: Amides; Analgesics; Animals; Cocaine; Codeine; Conditioning, Psychological; Dextropropoxyphene; Female; Fumarates; Haplorhini; Injections, Intravenous; Macaca; Male; Morphine; Nalorphine; Pentazocine; Piperidines; Propionates; Reinforcement, Psychology | 1972 |
Reaction gas chromatography. 3. Recognition of tropane structure in alkaloids.
Topics: Alkaloids; Atropine; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Gas; Cocaine; Nortropanes; Piperidines; Pyridines; Pyrroles; Pyrrolidines; Scopolamine; Toluene | 1967 |
[Short review of Marcaine characteristics].
Topics: Anesthesia, Local; Anilides; Chemistry, Pharmaceutical; Cocaine; Humans; Lidocaine; Piperidines; Procaine; Xylenes | 1968 |
Adrenaline reversal by CIBA 1002-Go.
Topics: Acetylcholine; Animals; Blood Pressure; Cats; Cocaine; Depression, Chemical; Dogs; Drug Synergism; Epinephrine; Female; Heart Rate; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Piperidines; Propranolol; Pyrazoles; Rabbits; Rats; Receptors, Drug; Stimulation, Chemical; Uterus | 1969 |
The acquisition of responding with conditioned reinforcement: effects of cocaine, (+)-amphetamine and pipradrol.
Topics: Animals; Cocaine; Conditioning, Operant; Dextroamphetamine; Male; Piperidines; Rats; Rats, Inbred Strains; Reinforcement, Psychology | 1981 |
Contrasting interactions of pipradrol, d-amphetamine, cocaine, cocaine analogues, apomorphine and other drugs with conditioned reinforcement.
Topics: Animals; Apomorphine; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dextroamphetamine; Flupenthixol; Male; Morphine; Piperidines; Rats; Reinforcement, Psychology | 1983 |
Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cocaine; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Nitriles; Piperidines; Rats; Rats, Inbred Strains; Self Administration | 1995 |
Effects of the dopamine autoreceptor antagonist (-)-DS121 on the discriminative stimulus properties of d-amphetamine and cocaine.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Caffeine; Cocaine; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Nitriles; Piperidines; Random Allocation; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1995 |
Thioperamide, the selective histamine H3 receptor antagonist, attenuates stimulant-induced locomotor activity in the mouse.
Topics: Amphetamine; Animals; Apomorphine; Central Nervous System Stimulants; Cocaine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; Mice; Motor Activity; Piperidines | 1994 |
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.
Topics: Animals; Carrier Proteins; Caudate Nucleus; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Protein Binding; Putamen; Serotonin; Serotonin Plasma Membrane Transport Proteins | 1994 |
Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites.
Topics: Animals; Binding Sites; Cocaine; Cyclohexylamines; Dopamine; Dopamine Antagonists; Phencyclidine; Piperidines; Rats; Structure-Activity Relationship | 1993 |
Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine.
Topics: Animals; Cocaine; Conditioning, Psychological; Discrimination Learning; Flavonoids; Male; Methamphetamine; Mice; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Seizures | 1993 |
Discriminative stimulus properties of cocaine in relation to dopamine D2 receptor function in rats.
Topics: Animals; Bromocriptine; Cocaine; Discrimination Learning; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 1993 |
Repeated testing within drug discrimination learning: time course studies with cocaine, amphetamine, and 3-PPP.
Topics: Amphetamine; Animals; Cocaine; Columbidae; Discrimination Learning; Dopamine Antagonists; Male; Piperidines; Time Factors | 1993 |
Effects of repeated administration of N-[1-(2-benzo(b)-thiophenyl)cyclohexy]piperidine and cocaine on locomotor activity in C57BL/6 mice.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Inbred C57BL; Piperidines; Sodium Chloride; Time Factors | 1996 |
N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine induce similar effects on striatal dopamine: a microdialysis study in freely moving rats.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Microdialysis; Piperidines; Rats; Rats, Wistar | 1996 |
Sigma ligand S14905 and locomotor activity in mice.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Hydroxamic Acids; Indans; Male; Mice; Morphine; Motor Activity; Narcotics; Piperidines; Radioligand Assay; Receptors, sigma; Stimulation, Chemical | 1995 |
Interactions between cocaine and (-)-DS 121: studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain.
Topics: Animals; Autoradiography; Brain Chemistry; Cocaine; Deoxyglucose; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Extracellular Space; Injections, Intravenous; Male; Microdialysis; Neostriatum; Nitriles; Piperidines; Rats; Rats, Sprague-Dawley | 1997 |
Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter.
Topics: Animals; Binding Sites; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Esters; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Chemical; Models, Molecular; Nerve Tissue Proteins; Piperidines; Rats; Rats, Sprague-Dawley; Tropanes | 1997 |
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Topics: Anesthetics, Local; Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Guinea Pigs; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Conformation; Nerve Tissue Proteins; Neuromuscular Depolarizing Agents; Neurotransmitter Agents; Piperidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tropanes; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1997 |
Mixed D2/5-HT2A antagonism of cocaine-induced facilitation of brain stimulation reward.
Topics: Animals; Brain; Cocaine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Piperidines; Rats; Rats, Sprague-Dawley; Reward; Risperidone; Self Stimulation; Serotonin Antagonists | 1998 |
Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.
Topics: Animals; Benzhydryl Compounds; Carrier Proteins; Cell Membrane; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1998 |
Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Crystallography, X-Ray; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperidines; Protein Binding; Rats; Stereoisomerism; Synaptosomes; Tropanes | 1998 |
Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
Topics: Animals; Carrier Proteins; Cell Line; Citalopram; Cloning, Molecular; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Transfection | 1998 |
5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dioxanes; Hyperkinesis; Male; Motor Activity; Nicotine; Piperidines; Rats; Rats, Sprague-Dawley; Self Stimulation; Serotonin Antagonists | 1998 |
Generalization of D-, L- and DL-chlorpheniramine and zolantidine to the discriminative stimulus effects of cocaine and methamphetamine.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzothiazoles; Chlorpheniramine; Clomipramine; Cocaine; Desipramine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Stimulus; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Methamphetamine; Middle Aged; Phenoxypropanolamines; Piperazines; Piperidines; Rats; Rats, Inbred F344; Thiazoles | 1997 |
5-HT2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB.
Topics: Aminopyridines; Amphetamine; Animals; Benzazepines; Cocaine; Dizocilpine Maleate; Dopamine Agonists; Drug Interactions; Female; Fluorobenzenes; Indoles; Mice; Motor Activity; Piperidines; Ritanserin; Serotonin Antagonists | 1999 |
Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.
Topics: 4-Aminobenzoic Acid; Aniline Compounds; Animals; Cocaine; Male; Nucleus Accumbens; para-Aminobenzoates; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
In-vitro and in-vivo action of cannabinoids.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cocaine; Cyclic AMP; Gene Expression; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Piperidines; Polymerase Chain Reaction; Pyrazoles; Receptors, AMPA; Recombinant Proteins; Rimonabant; Xenopus laevis | 1999 |
Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Organometallic Compounds; Organotechnetium Compounds; Piperidines; Protein Binding; Radioligand Assay; Rats; Tissue Distribution | 1999 |
Prenatal cocaine exposure potentiates 5-HT(2a) receptor function in male and female rat offspring.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cerebral Cortex; Cocaine; Corticosterone; Female; Fluorobenzenes; Male; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Renin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstrictor Agents | 2000 |
Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationshi
Topics: Animals; Carrier Proteins; Caudate Nucleus; Cocaine; Corpus Striatum; Databases, Factual; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Motor Activity; Nerve Tissue Proteins; Piperidines; Rats; Structure-Activity Relationship; Synaptosomes | 2000 |
Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.
Topics: Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; Piperazines; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Motor Activity; Nerve Endings; Nerve Tissue Proteins; Norepinephrine; Piperidines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship | 2000 |
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cannabinoids; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Dronabinol; Marijuana Smoking; Piperidines; Psychotropic Drugs; Pyrazoles; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration | 2000 |
The dopamine D2/D3 antagonist DS121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Tolerance; Locomotion; Male; Nitriles; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2000 |
CB1 cannabinoid receptor agonist WIN 55,212-2 decreases intravenous cocaine self-administration in rats.
Topics: Animals; Benzoxazines; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration | 1999 |
Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter.
Topics: Animals; Benzhydryl Compounds; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Ligands; Macaca mulatta; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Piperazines; Piperidines; Radioligand Assay; Tritium | 2001 |
Automated stereotactic standardization of brain SPECT receptor data using single-photon transmission images.
Topics: Adolescent; Adult; Aged; Benzamides; Brain; Brain Chemistry; Cocaine; Cysteine; Female; Humans; Image Processing, Computer-Assisted; Iodine Radioisotopes; Male; Middle Aged; Organotechnetium Compounds; Piperidines; Radiopharmaceuticals; Receptors, Dopamine; Receptors, Serotonin; Stereotaxic Techniques; Tomography, Emission-Computed, Single-Photon | 2001 |
Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperidines; Structure-Activity Relationship | 2001 |
Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Discrimination Learning; Dopamine; Fluorobenzenes; Ketanserin; Male; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists | 2001 |
Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
Topics: Animals; Carrier Proteins; Cocaine; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 2001 |
Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains.
Topics: Animals; Azides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Endopeptidases; Epitopes; In Vitro Techniques; Iodine Radioisotopes; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Peptide Mapping; Photoaffinity Labels; Piperidines; Precipitin Tests; Rats | 2001 |
Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors.
Topics: Animals; Carrier Proteins; Cocaine; Crystallography, X-Ray; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship; Symporters; Synaptosomes | 2001 |
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.
Topics: Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oxadiazoles; Piperidines; Structure-Activity Relationship | 2001 |
Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.
Topics: Benzhydryl Compounds; Brain; Carrier Proteins; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Drug Evaluation, Preclinical; Isomerism; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperidines; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2001 |
Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors.
Topics: Animals; Behavior, Animal; Catheterization; Cocaine; Fluorobenzenes; Male; Microinjections; Motor Activity; Neural Pathways; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiro Compounds; Sulfonamides; Ventral Tegmental Area | 2001 |
Cannabinoid activity curtails cocaine craving.
Topics: Animals; Cannabinoids; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dronabinol; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
A cannabinoid mechanism in relapse to cocaine seeking.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dronabinol; Humans; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Recurrence; Rimonabant | 2001 |
SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats.
Topics: Animals; Brain; Cocaine; Depression, Chemical; Electric Stimulation; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reinforcement, Psychology; Rimonabant; Selective Serotonin Reuptake Inhibitors; Self Stimulation | 2001 |
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Piperidines; Radioligand Assay; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 2002 |
Evaluation of the reinforcing effects of the cannabinoid CB1 receptor antagonist, SR141716, in rhesus monkeys.
Topics: Animals; Cannabinoids; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration | 2002 |
Neurokinin receptors modulate the neurochemical actions of cocaine.
Topics: Analysis of Variance; Animals; Cocaine; Corpus Striatum; Dopamine; Male; Microdialysis; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1 | 2002 |
SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; Esters; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters; Synaptosomes | 2002 |
Modulation of the discriminative stimulus effects of cocaine and methamphetamine by the histaminergic system.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Discrimination Learning; Drug Synergism; Histamine; Histamine Antagonists; Histidine; Male; Methamphetamine; Piperidines; Rats; Rats, Inbred F344; Receptors, Histamine H1; Receptors, Histamine H3 | 2002 |
Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms.
Topics: Animals; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Kinetics; Ligands; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Self Administration; Symporters | 2002 |
Observing responses maintained by stimuli associated with cocaine or remifentanil reinforcement in rhesus monkeys.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Injections, Intravenous; Macaca mulatta; Male; Photic Stimulation; Piperidines; Reinforcement, Psychology; Remifentanil; Self Administration | 2002 |
Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding.
Topics: Aminopyridines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluorobenzenes; Indoles; Male; Motor Activity; Neural Pathways; Piperidines; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Self Administration; Serotonin; Serotonin Antagonists | 2002 |
Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats.
Topics: Analysis of Variance; Animals; Benzimidazoles; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Injections, Intraventricular; Locomotion; Male; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Time Factors; Ventral Tegmental Area | 2002 |
Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites.
Topics: Animals; Cell Line; Cocaine; Cocaine-Related Disorders; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Humans; Hyperkinesis; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperidines; Radioligand Assay; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 2002 |
Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter.
Topics: Animals; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Piperidines; Radioligand Assay; Stereoisomerism; Structure-Activity Relationship | 2003 |
Variability of drug self-administration in rats.
Topics: Analgesics, Opioid; Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Male; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement Schedule; Remifentanil; Self Administration | 2003 |
High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.
Topics: Animals; Benzhydryl Compounds; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Crystallography, X-Ray; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Molecular Structure; Motor Activity; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioligand Assay; Rats; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters | 2003 |
Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine.
Topics: Animals; Cocaine; Discrimination Learning; Humans; Infusions, Intravenous; Macaca mulatta; Mice; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Self Administration | 2003 |
H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Attention; Avoidance Learning; Central Nervous System Stimulants; Cocaine; Cognition; Dextroamphetamine; Dose-Response Relationship, Drug; Histamine Antagonists; Male; Methylphenidate; Motor Activity; Piperidines; Rats; Rats, Inbred SHR; Receptors, Histamine H3 | 2003 |
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Donepezil; Indans; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Nucleus Accumbens; Pain; Piperidines; Substance Withdrawal Syndrome | 2003 |
WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation.
Topics: Algorithms; Animals; Benzoxazines; Brain; Cocaine; Conditioning, Operant; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reinforcement, Psychology; Reward; Rimonabant; Self Stimulation; Stimulation, Chemical | 2003 |
Opioids, cocaine, and food change runtime distribution in a rat runway procedure.
Topics: Alfentanil; Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Milk; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement, Psychology; Remifentanil | 2003 |
The effect of cannabinoid receptor antagonism with SR141716A on antinociception induced by cocaine and the NMDA receptor antagonist, MK-801.
Topics: Anesthetics, Local; Animals; Cannabinoid Receptor Modulators; Cocaine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2003 |
The enzymic hydrolysis of cocaine and alpha-cocaine.
Topics: Blood; Cocaine; Humans; Hydrolysis; Piperidines | 1955 |
ENHANCEMENT BY RESERPINE AND ALPHA-METHYL DOPA OF THE EFFECTS OF D-AMPHETAMINE UPON THE LOCOMOTOR ACTIVITY OF MICE.
Topics: Antihypertensive Agents; Brain; Cocaine; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Locomotion; Methyldopa; Mice; Motor Activity; Pharmacology; Piperidines; Research; Reserpine; Serotonin | 1963 |
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE.
Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine | 1964 |
ANTAGONISM OF CERTAIN EFFECTS OF CATECHOLAMINE-DEPLETING AGENTS BY ANTIDEPRESSANT AND RELATED DRUGS.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dogs; Dopamine; Electric Stimulation; Electrophysiology; Guanethidine; Imipramine; Metaraminol; Methylphenidate; Mice; Myocardium; Nictitating Membrane; Norepinephrine; Pharmacology; Piperidines; Promazine; Research; Reserpine; Tripelennamine; Tyrosine | 1964 |
EFFECTS OF D-AMPHETAMINE UPON OPERANT BEHAVIOR OF PIGEONS: ENHANCEMENT BY RESERPINE.
Topics: Animals; Behavior, Animal; Birds; Cocaine; Columbidae; Conditioning, Psychological; Dextroamphetamine; Imipramine; Movement; Piperidines; Psychopharmacology; Research; Reserpine | 1964 |
EFFECTS OF D-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Cocaine; Dextroamphetamine; Dopamine; Iproniazid; Metabolism; Mice; Motor Activity; Movement; Norepinephrine; Pharmacology; Piperidines; Research; Reserpine; Serotonin | 1965 |
POTENTIATION OF NOREPINEPHRINE IN THE ISOLATED VAS DEFERENS OF THE RAT BY SOME CNS STIMULANTS AND ANTIDEPRESSANTS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Cocaine; Desipramine; Humans; Imipramine; Male; Methylphenidate; Norepinephrine; Pharmacology; Phenmetrazine; Piperidines; Rats; Research; Tranquilizing Agents; Vas Deferens | 1965 |
EFFECT OF VARIOUS PRETREATMENTS ON RESPONSES TO EPHEDRINE ISOMERS.
Topics: Blood Pressure; Cocaine; Dogs; Ephedrine; Guanethidine; Heart; Heart Rate; Isomerism; Methylphenidate; Pharmacology; Piperidines; Research | 1965 |
INVESTIGATION ON THE SYMPATHOMIMETIC PROPERTIES OF PHENCYCLIDINE BY COMPARISON WITH COCAINE AND DESOXYEPHEDRINE.
Topics: Anesthetics; Animals; Anticonvulsants; Blood Pressure; Central Nervous System; Cocaine; Dogs; Fluids and Secretions; Guanidine; Guanidines; Iproniazid; Methamphetamine; Nervous System; Pharmacology; Phencyclidine; Piperidines; Research; Reserpine; Sympathomimetics; Urine | 1965 |
Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in delta -sup-9-tetrahydrocannabinol-treated rhesus monkeys.
Topics: Anesthetics; Animals; Behavior, Animal; Cannabinoids; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Ketamine; Macaca mulatta; Male; Photic Stimulation; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2003 |
Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Benzazepines; Blinking; Cocaine; Conditioning, Operant; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Hierarchy, Social; Macaca fascicularis; Male; Neostriatum; Piperidines; Receptors, Dopamine D1; Receptors, Dopamine D2; Self Administration; Tissue Distribution; Tomography, Emission-Computed | 2004 |
Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats.
Topics: Amphetamine; Animals; Cannabidiol; Cocaine; Conditioning, Operant; Dronabinol; Extinction, Psychological; Learning; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring.
Topics: Animals; Binding Sites; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Rats; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 2004 |
Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons.
Topics: Action Potentials; Age Factors; Amphetamine; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cocaine; Critical Period, Psychological; Dopamine; Dose-Response Relationship, Drug; Drug Tolerance; Electrophysiology; Illicit Drugs; Male; Morphine; Morpholines; Naphthalenes; Nerve Net; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Ventral Tegmental Area | 2004 |
CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cocaine; Extinction, Psychological; Heroin; Male; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Time Factors | 2004 |
Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine tr
Topics: Animals; Benzhydryl Compounds; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cocaine; Corpus Striatum; Crystallography, X-Ray; Discrimination Learning; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Molecular Conformation; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioligand Assay; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters | 2004 |
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.
Topics: Animals; Benzhydryl Compounds; Biological Availability; Cocaine; Dopamine Plasma Membrane Transport Proteins; Drug Design; In Vitro Techniques; Ligands; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Modafinil; Motor Activity; Nerve Endings; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Rats; Serotonin Plasma Membrane Transport Proteins; Symporters; Synaptosomes | 2004 |
CoMFA study of piperidine analogues of cocaine at the dopamine transporter: exploring the binding mode of the 3 alpha-substituent of the piperidine ring using pharmacophore-based flexible alignment.
Topics: Algorithms; Binding Sites; Cocaine; Dopamine Plasma Membrane Transport Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Molecular Conformation; Molecular Structure; Nerve Tissue Proteins; Piperidines; Quantitative Structure-Activity Relationship | 2004 |
Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Movement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reinforcement, Psychology; Rimonabant; Self Administration; Substance Abuse, Intravenous | 2005 |
Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Binding Sites; Binding, Competitive; Biological Transport; Cell Line; Cell Membrane; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutation; Nerve Tissue Proteins; Norepinephrine; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism; Synaptosomes; Tritium | 2004 |
Lack of CB1 cannabinoid receptor impairs cocaine self-administration.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Feeding Behavior; Food Deprivation; Mice; Mice, Knockout; Microdialysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Time Factors; Water Deprivation | 2005 |
The H3 antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Histamine Antagonists; Locomotion; Male; Mice; Mice, Inbred C57BL; Piperidines; Receptors, Histamine H3; Reinforcement, Psychology | 2005 |
Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter.
Topics: Animals; Benzhydryl Compounds; Binding, Competitive; Brain; Cell Line; Cocaine; Dopamine; Humans; In Vitro Techniques; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Agents; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2005 |
The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cocaine; Endocannabinoids; Infusions, Intravenous; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration; Stereoisomerism; Substance-Related Disorders | 2005 |
WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT(3) receptor function.
Topics: Animals; Benzoxazines; Cocaine; Dose-Response Relationship, Drug; Male; Morpholines; Motor Activity; Naphthalenes; Ondansetron; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Rimonabant; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists | 2005 |
Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Cannabinoids; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine; Drug Administration Routes; Drug Interactions; gamma-Aminobutyric Acid; Male; Microdialysis; Morphine; Neural Pathways; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration; Time Factors | 2006 |
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats.
Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Electroshock; Foot; Male; Motor Activity; Piperidines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Secondary Prevention; Self Administration; Stress, Psychological; Swimming; Tetrahydroisoquinolines | 2005 |
Relationship of cocaine-induced c-Fos expression to behaviors and the role of serotonin 5-HT2A receptors in cocaine-induced c-Fos expression.
Topics: Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Cell Count; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; Immunohistochemistry; Male; Motor Activity; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin Antagonists | 2005 |
Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.
Topics: Animals; Benzylamines; Calcium; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; Mesylates; N-Methylaspartate; Nomifensine; Pentazocine; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Sulfonamides; Tritium | 2006 |
Relative reinforcing effects of cocaine, remifentanil, and their combination in rhesus monkeys.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Drug Combinations; Female; Macaca mulatta; Male; Piperidines; Reaction Time; Reinforcement, Psychology; Remifentanil | 2006 |
The tachykinin NK3 receptor antagonist SR142801 blocks the behavioral effects of cocaine in marmoset monkeys.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Callithrix; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Exploratory Behavior; Injections, Intraperitoneal; Male; Maze Learning; Motor Activity; Piperidines; Receptors, Neurokinin-3 | 2006 |
Effects of the H3-receptor inverse agonist thioperamide on the psychomotor effects induced by acutely and repeatedly given cocaine in C57BL/6J mice.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Histamine Antagonists; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Psychomotor Performance; Receptors, Histamine H3; Stereotyped Behavior | 2006 |
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine.
Topics: Animals; Blood-Brain Barrier; Brain; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Mice; Neurotransmitter Transport Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioactive Tracers; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Tissue Distribution; Tropanes | 2006 |
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Recurrence; Reward | 2006 |
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2006 |
Neurokinin receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine-enhancing action in the nucleus accumbens core.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Fluid; Homovanillic Acid; Locomotion; Male; Microdialysis; Nucleus Accumbens; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3 | 2006 |
CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Cannabinoids; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptosomes | 2007 |
Effects of ifenprodil on the discriminative stimulus effects of cocaine in rhesus monkeys.
Topics: Animals; Cocaine; Discrimination, Psychological; Female; Macaca mulatta; Male; Piperidines; Receptors, N-Methyl-D-Aspartate | 2007 |
Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses | 2007 |
Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity.
Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Hyperkinesis; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Tritium | 2007 |
Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Mutation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
A behavioral economic analysis of cocaine and remifentanil self-administration in rhesus monkeys.
Topics: Algorithms; Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Macaca mulatta; Male; Piperidines; Reaction Time; Reinforcement Schedule; Remifentanil; Self Administration; Vasoconstrictor Agents | 2007 |
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Administration | 2008 |
A stimulus-control account of regulated drug intake in rats.
Topics: Analgesics, Opioid; Animals; Cocaine; Conditioning, Operant; Cues; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Light; Male; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Reward; Self Administration | 2008 |
Self-administration of drug mixtures by monkeys: combining drugs with comparable mechanisms of action.
Topics: Alfentanil; Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Macaca mulatta; Male; Piperidines; Reinforcement Schedule; Reinforcement, Psychology; Remifentanil; Self Administration | 2008 |
Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Cocaine; Conditioning, Operant; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Piperidines; Receptors, Dopamine D1; Reinforcement, Psychology; Remifentanil; Self Administration; Statistics, Nonparametric | 2007 |
Context-specific reversal of cocaine sensitization by the CB1 cannabinoid receptor antagonist rimonabant.
Topics: Animals; Behavior, Addictive; Cocaine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The endogenous OFQ/N/ORL-1 receptor system regulates the rewarding effects of acute cocaine.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Benzimidazoles; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Receptors, Opioid; Reward; Time Factors | 2008 |
Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Endocannabinoids; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation; Synaptic Transmission | 2008 |
Nucleus accumbens core acetylcholine is preferentially activated during acquisition of drug- vs food-reinforced behavior.
Topics: Acetylcholine; Animals; Cholinergic Antagonists; Cocaine; Conditioning, Psychological; Disease Models, Animal; Dopamine; Feeding Behavior; Learning; Male; Morphine; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Reinforcement, Psychology; Remifentanil; Substance-Related Disorders; Synaptic Transmission | 2008 |
Activation of amygdaloid PKC pathway is necessary for conditioned cues-provoked cocaine memory performance.
Topics: Amygdala; Animals; Anisomycin; Cocaine; Conditioning, Classical; Cycloheximide; Dopamine Uptake Inhibitors; Extracellular Signal-Regulated MAP Kinases; Isoquinolines; Male; Memory; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Space Perception; Sulfonamides | 2008 |
Self-administration of cocaine-remifentanil mixtures by monkeys: an isobolographic analysis.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Combinations; Macaca mulatta; Male; Opioid-Related Disorders; Piperidines; Regression Analysis; Remifentanil; Self Administration; Substance-Related Disorders | 2008 |
Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions.
Topics: Animals; Area Under Curve; Biphenyl Compounds; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Histamine; Histamine Agonists; Histamine Release; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nitriles; Piperidines; Pyrrolidines; Receptors, Histamine H3 | 2009 |
Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice.
Topics: Animals; Cocaine; Dopamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Chromones; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Drug Combinations; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mesencephalon; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2 | 2008 |
Selective suppression of cocaine- versus food-maintained responding by monoamine releasers in rhesus monkeys: benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine.
Topics: Animals; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dopamine Uptake Inhibitors; Food; Macaca mulatta; Male; Norepinephrine; Phenmetrazine; Piperazines; Piperidines; Reward; Serotonin; Synaptosomes | 2009 |
Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Locomotion; Male; Milk; Piperidines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Thiazoles | 2009 |
Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extinction, Psychological; Fluorobenzenes; Food Deprivation; Male; Piperidines; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists | 2009 |
A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions.
Topics: Animals; Behavior, Addictive; Cannabinoid Receptor Modulators; Cocaine; Endocannabinoids; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2009 |
Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters.
Topics: Animals; Benzhydryl Compounds; Brain; Cocaine; Dopamine Plasma Membrane Transport Proteins; Mice; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Rats; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism | 2009 |
Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens.
Topics: Analysis of Variance; Animals; Butadienes; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Locomotion; Male; Nitriles; Nucleus Accumbens; Piperidines; Psychomotor Performance; Rats; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Time Factors | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
The CB1 antagonist rimonabant (SR141716) blocks cue-induced reinstatement of cocaine seeking and other context and extinction phenomena predictive of relapse.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corn Oil; Cues; Dietary Sucrose; Disease Models, Animal; Extinction, Psychological; Food, Formulated; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement Schedule; Rimonabant; Self Administration; Water | 2009 |
Sex and cannabinoid CB1 genotype differentiate palatable food and cocaine self-administration behaviors in mice.
Topics: Animals; Cocaine; Conditioning, Operant; Corn Oil; Feeding Behavior; Female; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Self Administration; Sex Characteristics | 2009 |
Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice.
Topics: Animals; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Male; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Reward; Time Factors | 2010 |
Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors.
Topics: Animals; Avoidance Learning; Cocaine; Conditioning, Classical; Drug Inverse Agonism; Gene Silencing; Lentivirus; Ligands; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Glutamate; Reward; Rimonabant | 2010 |
Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Decanoic Acids; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Maze Learning; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Swimming | 2010 |
Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation.
Topics: Animals; Benzamides; Benzazepines; Blinking; Cocaine; Dopamine Agonists; Female; Fluorine Radioisotopes; Macaca mulatta; Male; Piperidines; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Quinpirole; Radioligand Assay; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Yawning | 2010 |
Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.
Topics: Animals; Behavior, Animal; beta-Cyclodextrins; Brain-Derived Neurotrophic Factor; Cholesterol; Cocaine; Corpus Striatum; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dronabinol; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agents; Haloperidol; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward | 2010 |
Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats.
Topics: Analgesics, Opioid; Animals; Benzimidazoles; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Combinations; Imidazoles; Injections, Intraperitoneal; Male; Morphine Derivatives; Motivation; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reward; Spiro Compounds | 2010 |
Reinforcer-dependent enhancement of operant responding in opioid-withdrawn rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Remifentanil; Self Administration; Substance Withdrawal Syndrome | 2010 |
Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats.
Topics: Aminopyridines; Animals; Behavior, Animal; Cocaine; Dopamine; Dose-Response Relationship, Drug; Fluorobenzenes; Glutamic Acid; Indoles; Male; Microdialysis; Neuronal Plasticity; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists | 2011 |
The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization.
Topics: Animals; Behavior, Animal; Benzhydryl Compounds; Cocaine; Cocaine-Related Disorders; Discrimination, Psychological; Dopamine Uptake Inhibitors; Generalization, Stimulus; Male; Piperidines; Rats | 2010 |
The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Aza Compounds; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Corpus Striatum; Depression; Discrimination, Psychological; Dopamine; Dopamine Uptake Inhibitors; Hindlimb Suspension; Hypothalamus; Locomotion; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming; Synaptosomes | 2010 |
Effects of cannabinoid CB₁ receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice.
Topics: Animals; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Memory; Methamphetamine; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Reward; Rimonabant | 2011 |
Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells.
Topics: Action Potentials; Animals; Animals, Newborn; Behavior, Animal; Benzoxazines; Cocaine; Dopamine; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Illicit Drugs; In Vitro Techniques; Male; Mecamylamine; Morphine; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Neurons; Nicotinic Antagonists; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors; Ventral Tegmental Area | 2011 |
Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation.
Topics: Animals; Calcium; Cocaine; Conditioning, Psychological; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Mice; Motor Activity; Neurons; Phenols; Phosphorylation; Piperidines; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; src-Family Kinases; Tyrosine | 2011 |
Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.
Topics: Animals; Cocaine; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nucleus Accumbens; Piperidines; Pyrazoles; Synaptic Potentials; TRPV Cation Channels | 2010 |
Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Fluorobenzenes; Male; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Self Administration; Serotonin 5-HT2 Receptor Antagonists; Sucrose | 2011 |
Sensitization to cocaine is inhibited after intra-accumbal GR103691 or rimonabant, but it is enhanced after co-infusion indicating functional interaction between accumbens D(3) and CB1 receptors.
Topics: Animals; Biphenyl Compounds; Cocaine; Dose-Response Relationship, Drug; Drug Inverse Agonism; Drug Synergism; Infusions, Intraventricular; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Piperazines; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Rimonabant | 2011 |
Self-administration of cocaine and remifentanil by monkeys: choice between single drugs and mixtures.
Topics: Animals; Behavior, Animal; Choice Behavior; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Hypnotics and Sedatives; Macaca mulatta; Male; Piperidines; Reinforcement Schedule; Remifentanil; Self Administration | 2011 |
Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluorenes; Macaca mulatta; Male; Piperazines; Piperidines; Quinpirole; Receptors, Dopamine D3; Reinforcement, Psychology; Self Administration; Yawning | 2011 |
Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT(2C) receptor stimulation and 5-HT(2A) receptor blockade.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethylamines; Excitatory Amino Acid Antagonists; Fluorobenzenes; Impulsive Behavior; Indoles; Male; Piperidines; Psychomotor Performance; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, N-Methyl-D-Aspartate; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2011 |
Effects of the selective sigma receptor ligand, 1-(2-phenethyl)piperidine oxalate (AC927), on the behavioral and toxic effects of cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ligands; Macaca mulatta; Male; Mice; Models, Animal; Molecular Targeted Therapy; Motor Activity; Oxalates; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Seizures; Self Administration | 2011 |
Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats.
Topics: Animals; Cocaine; Fluorobenzenes; Impulsive Behavior; Male; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; Reinforcement, Psychology | 2011 |
Effects of daily morphine administration and deprivation on choice and demand for remifentanil and cocaine in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Choice Behavior; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Macaca mulatta; Male; Morphine; Morphine Dependence; Motivation; Piperidines; Remifentanil; Substance Withdrawal Syndrome | 2011 |
A silent synapse-based mechanism for cocaine-induced locomotor sensitization.
Topics: Animals; Cocaine; Cyclic AMP Response Element-Binding Protein; Dendritic Spines; Gene Expression Regulation; Genetic Vectors; Male; Microinjections; Motor Activity; Nucleus Accumbens; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sindbis Virus; Synapses | 2011 |
Individual differences in rhesus monkeys' demand for drugs of abuse.
Topics: Anesthetics; Animals; Central Nervous System Depressants; Cocaine; Conditioning, Operant; Ethanol; Female; Individuality; Ketamine; Macaca mulatta; Male; Methohexital; Piperidines; Reinforcement, Psychology; Remifentanil; Substance-Related Disorders | 2012 |
Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Hypothalamo-Hypophyseal System; Male; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2012 |
Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Biophysics; Calcium Channel Blockers; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Signal Transduction; Synapses; Ventral Tegmental Area | 2011 |
Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
Topics: Animals; Anisoles; Antipsychotic Agents; Carbazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Molecular Targeted Therapy; Oxalates; Piperidines; Propylamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement, Psychology; Self Administration | 2011 |
Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Addictive; Cannabinoids; Cocaine; Conditioning, Psychological; Cyclohexanols; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Imidazoles; Isoindoles; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Self Administration; Stress, Psychological | 2012 |
Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism.
Topics: Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Protein Kinase C; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses | 2011 |
Desoxypipradrol is more potent than cocaine on evoked dopamine efflux in the nucleus accumbens.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Electrical Synapses; Illicit Drugs; In Vitro Techniques; Kinetics; Male; Neurons; Nucleus Accumbens; Osmolar Concentration; Piperidines; Psychotropic Drugs; Rats; Rats, Wistar; Synaptic Transmission | 2012 |
Inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cocaine; Dopaminergic Neurons; Electric Stimulation; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Morphine; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Neural Inhibition; Neural Pathways; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Tegmentum Mesencephali; Time Factors; Ventral Tegmental Area | 2012 |
Reversible and persistent decreases in cocaine self-administration after cholinesterase inhibition: different effects of donepezil and rivastigmine.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cocaine; Donepezil; Dopamine Uptake Inhibitors; Female; Indans; Male; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Reinforcement, Psychology; Rivastigmine; Self Administration | 2011 |
Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys.
Topics: Amphetamine; Animals; Cocaine; Discrimination Learning; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Dronabinol; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tropanes | 2012 |
Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward.
Topics: Animals; Behavior, Animal; Benztropine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Exploratory Behavior; Histamine H1 Antagonists; Illicit Drugs; Kinetics; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nucleus Accumbens; Piperidines; Psychomotor Agitation; Reward; Spatial Behavior | 2012 |
Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Electroshock; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Self Administration; Stress, Physiological | 2012 |
13C GIAO DFT calculation as a tool for configuration prediction of N-O group in saturated heterocyclic N-oxides.
Topics: Carbon Isotopes; Cocaine; Cyclic N-Oxides; Models, Chemical; Molecular Conformation; Nitrogen; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Oxygen; Piperidines; Predictive Value of Tests; Stereoisomerism; Tropanes | 2012 |
5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen.
Topics: Animals; Caudate Nucleus; Cocaine; Fluorobenzenes; Gene Expression Regulation; Locomotion; Male; Piperidines; Proto-Oncogene Proteins c-fos; Putamen; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2012 |
Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Benzazepines; Cocaine; Disease Models, Animal; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Electric Stimulation; Female; Indoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Raclopride; Receptors, Dopamine D1; Reward; Self Stimulation; Substantia Nigra; Synaptic Transmission; Ubiquitin-Protein Ligases; Ventral Tegmental Area | 2012 |
Antagonizing 5-HT₂A receptors with M100907 and stimulating 5-HT₂C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats.
Topics: Animals; Behavior, Animal; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Early Growth Response Protein 1; Ethylamines; Fluorobenzenes; Frontal Lobe; Indoles; Male; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; RNA, Messenger; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2013 |
Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity.
Topics: Animals; Behavior, Animal; Cocaine; Cycloheptanes; Dopamine; Dose-Response Relationship, Drug; Locomotion; Male; Microdialysis; Motor Activity; Nociceptin; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.
Topics: Amphetamine; Animals; Anorexia; Cocaine; Hyperkinesis; Male; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Nucleus Accumbens; Piperidines; Propane; Real-Time Polymerase Chain Reaction; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Antagonists | 2012 |
Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice.
Topics: Animals; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Endocannabinoids; Mice; Microdialysis; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Binding, Competitive; Cocaine; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Imidazoles; In Vitro Techniques; Infusions, Intravenous; Inhibitory Concentration 50; Male; Motor Activity; Nitriles; Piperidines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5; Reinforcement Schedule; Reward; Secondary Prevention; Self Administration; Sucrose; Thiazoles | 2014 |
Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats.
Topics: Animals; Apomorphine; Benzamides; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electroshock; Food Deprivation; Indoles; Lisuride; Male; Piperidines; Pyridines; Quinpirole; Raclopride; Rats, Sprague-Dawley; Reinforcement, Psychology | 2014 |
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.
Topics: Animals; Cannabinoid Receptor Antagonists; Cocaine; Conditioning, Operant; Cues; Dopamine; Dopaminergic Neurons; Endocannabinoids; Impulsive Behavior; Male; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Time Factors | 2014 |
The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alcohol-Related Disorders; Animals; Behavior, Addictive; Brain; Central Nervous System Depressants; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Ethanol; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, Neurokinin-1; Recurrence; Saccharin; Species Specificity; Stress, Psychological; Yohimbine | 2014 |
Cannabinoid type-1 receptor ligands, alone or in combination with cocaine, affect vigilance-related behaviors of marmoset monkeys.
Topics: Analysis of Variance; Animals; Anxiety; Benzoxazines; Calcium Channel Blockers; Callithrix; Cocaine; Dopamine Uptake Inhibitors; Female; Ligands; Locomotion; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Time Factors | 2014 |
Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Choice Behavior; Cocaine; Conditioning, Operant; Diterpenes, Clerodane; Macaca mulatta; Male; Piperidines; Punishment; Receptors, Opioid, kappa; Remifentanil; Self Administration | 2014 |
Random-ratio schedules produce greater demand for i.v. drug administration than fixed-ratio schedules in rhesus monkeys.
Topics: Administration, Intravenous; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Ketamine; Macaca mulatta; Male; Motivation; Piperidines; Reinforcement Schedule; Remifentanil; Reward; Self Administration; Substance-Related Disorders | 2014 |
Eating high fat chow and the behavioral effects of direct-acting and indirect-acting dopamine receptor agonists in female rats.
Topics: Aging; Animals; Body Temperature; Body Weight; Cocaine; Diet, High-Fat; Dietary Fats; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Eating; Female; Hypothermia; Indoles; Insulin Resistance; Motor Activity; Piperidines; Quinpirole; Rats, Sprague-Dawley; Receptors, Dopamine D2; Yawning | 2014 |
Self-administration of cocaine and remifentanil by monkeys under concurrent-access conditions.
Topics: Analgesics, Opioid; Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Haplorhini; Macaca mulatta; Male; Piperidines; Reinforcement Schedule; Reinforcement, Psychology; Remifentanil; Self Administration; Substance-Related Disorders | 2015 |
Variations in the stimulus salience of cocaine reward influences drug-associated contextual memory.
Topics: Aminoacetonitrile; Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Male; Memory; Mice, Inbred C57BL; Nitric Oxide Synthase Type I; Piperidines; Receptors, N-Methyl-D-Aspartate; Reward | 2016 |
Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice.
Topics: Animals; Cannabinoid Receptor Antagonists; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Memory; Mice; Mice, Inbred C57BL; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice.
Topics: Akathisia, Drug-Induced; Animals; Animals, Outbred Strains; Anxiety; Cannabinoid Receptor Antagonists; Central Nervous System Depressants; Cocaine; Depression; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Morphine; Motor Activity; Narcotics; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2015 |
BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Endocannabinoids; Enzyme Inhibitors; In Vitro Techniques; Indole Alkaloids; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Piperidines; Pyrazoles; Receptors, Glutamate; RNA, Untranslated; Signal Transduction; Synapses; Time Factors | 2015 |
CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats.
Topics: Animals; Arachidonic Acids; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Endocannabinoids; Extinction, Psychological; Glycerides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Self Administration; Stress, Psychological | 2016 |
Endocannabinoid signaling mediates oxytocin-driven social reward.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Benzodiazepines; Camphanes; Carbamates; Clozapine; Cocaine; Endocannabinoids; Immunohistochemistry; Infusions, Intraventricular; Lipids; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Oxytocin; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Reward; Signal Transduction; Social Behavior | 2015 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Depressants; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine Uptake Inhibitors; Ethanol; Exploratory Behavior; Feeding Behavior; Illicit Drugs; Leptin; Locomotion; Male; Mice; Motor Activity; Piperidines; Remifentanil; Taste | 2016 |
Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine.
Topics: Animals; Behavior, Addictive; Cocaine; Dendritic Spines; Endocannabinoids; Estradiol; Female; Motor Activity; Nucleus Accumbens; Ovariectomy; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics | 2016 |
Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.
Topics: Analgesics, Opioid; Anesthetics; Animals; Brain; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine; Extinction, Psychological; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Remifentanil; Self Administration; Time Factors | 2016 |
Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter.
Topics: Animals; Autoreceptors; Cocaine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Synergism; Female; Indoles; Male; Mice; Mice, Inbred C57BL; Nitriles; Piperidines; Raclopride; Receptors, Dopamine D2; Receptors, Tumor Necrosis Factor, Member 25; Sex Characteristics; Tetrahydroisoquinolines | 2016 |
Action of Pitolisant on the stimulant and rewarding effects of cocaine in mice.
Topics: Animals; Cocaine; Conditioning, Psychological; Locomotion; Male; Mice; Mice, Inbred C57BL; Piperidines; Reward; Spatial Behavior | 2016 |
Induction and Blockade of Adolescent Cocaine-Induced Habits.
Topics: Animals; Cocaine; Conditioning, Operant; Decision Making; Dendritic Spines; Drug-Seeking Behavior; Goals; Habits; Imatinib Mesylate; Male; Mice; Mice, Inbred C57BL; Piperidines; Prefrontal Cortex; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 2017 |
Attenuation of Cocaine-Induced Conditioned Place Preference and Motor Activity via Cannabinoid CB2 Receptor Agonism and CB1 Receptor Antagonism in Rats.
Topics: Animals; Cannabinoids; Cocaine; Conditioning, Classical; Indoles; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2017 |
Post-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in mice.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cocaine; Locomotion; Male; Mice; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rimonabant | 2017 |
Intravenous self-administration of benzydamine, a non-steroidal anti-inflammatory drug with a central cannabinoidergic mechanism of action.
Topics: Administration, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzydamine; Cocaine; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Heroin; Long-Term Synaptic Depression; Narcotics; Neural Pathways; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Self Administration; Synaptic Transmission | 2018 |
Effects of Acute and Chronic Treatments with Dopamine D
Topics: Aminopyridines; Animals; Benzamides; Choice Behavior; Cocaine; Conditioning, Operant; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Tolerance; Food; Indoles; Ligands; Male; Morpholines; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Reinforcement, Psychology | 2017 |
Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.
Topics: Animals; Behavior, Animal; Buprenorphine; Cocaine; Conditioning, Operant; Cycloheptanes; Dopamine Uptake Inhibitors; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Rats; Receptors, Opioid; Receptors, Opioid, mu; Self Administration | 2018 |
17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Estradiol; Estrogens; Female; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration; Sex Factors | 2018 |
Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.
Topics: Animals; beta-Arrestin 2; Cell Line, Tumor; Central Nervous System Agents; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Female; Ghrelin; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Piperidines; Quinazolinones; Receptors, Ghrelin | 2018 |
Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex.
Topics: Animals; Arachidonic Acids; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Endocannabinoids; Extinction, Psychological; Glucocorticoids; Glycerides; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Self Administration; Stress, Psychological | 2018 |
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Flupenthixol; Long-Term Synaptic Depression; Male; Mice; Morpholines; Naphthalenes; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rimonabant; Synaptic Transmission | 2018 |
Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Addictive; Benzamides; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Heroin; Male; Motivation; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Thiazoles | 2018 |
Effects of the monoamine stabilizer (-)-OSU6162 on locomotor and sensorimotor responses predictive of antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Ketamine; Locomotion; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia | 2018 |
The putative lithium-mimetic ebselen reduces impulsivity in rodent models.
Topics: Animals; Azoles; Choice Behavior; Cocaine; Fluorobenzenes; Impulsive Behavior; Isoindoles; Male; Models, Animal; Neuroprotective Agents; Organoselenium Compounds; Piperidines; Rats; Reaction Time | 2018 |
Pitolisant and intravenous cocaine self-administration in mice.
Topics: Administration, Intravenous; Animals; Behavior, Animal; Cocaine; Male; Mice; Mice, Inbred C57BL; Piperidines; Self Administration | 2019 |
Selective D
Topics: Action Potentials; Animals; Benzamides; Central Nervous System Sensitization; Cocaine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Mice; Motor Activity; Neurons; Nucleus Accumbens; Piperidines; Pyridines; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2019 |
Synaptic Depotentiation and mGluR5 Activity in the Nucleus Accumbens Drive Cocaine-Primed Reinstatement of Place Preference.
Topics: Animals; Cocaine; Conditioning, Operant; Electrophysiological Phenomena; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Signal Transduction; Synaptic Potentials; Thiazoles | 2019 |
Newly Developed Dopamine D
Topics: Animals; Blood Pressure; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Heart Rate; Indoles; Male; Nitriles; Oxycodone; Piperazines; Piperidines; Rats; Rats, Long-Evans; Receptors, Dopamine D3; Tetrahydroisoquinolines | 2019 |
Potent and selective NOP receptor activation reduces cocaine self-administration in rats by lowering hedonic set point.
Topics: Animals; Buprenorphine; Cocaine; Cocaine-Related Disorders; Cycloheptanes; Indoles; Male; Nociceptin Receptor; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reinforcement Schedule; Self Administration | 2020 |
OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes.
Topics: Animals; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ligands; Male; Nucleus Accumbens; Piperidines; Protein Binding; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Self Administration | 2020 |
Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice.
Topics: Animals; Aripiprazole; Behavior, Animal; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Locomotion; Male; Mice; Piperidines | 2021 |
Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization.
Topics: Animals; Behavior, Animal; Cocaine; Excitatory Amino Acid Antagonists; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Nucleus Accumbens; Piperidines; Protein Kinase Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2021 |
Enhancement of the GluN2B subunit of glutamatergic NMDA receptors in rat brain areas after cocaine abstinence.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Hippocampus; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Administration | 2021 |
Developmental treatments with Δ
Topics: Benzodioxoles; Cannabinoids; Cocaine; Dronabinol; Endocannabinoids; Piperidines | 2023 |
The lowdown on Ginkgo biloba.
Topics: Acetylcarnitine; Acetylcholine; Alzheimer Disease; Animals; Antioxidants; Brain; Candy; Cognition; Dietary Sucrose; Dietary Supplements; Donepezil; Ginkgo biloba; Glucose; Humans; Indans; Memory; Neurotransmitter Agents; Phosphatidylcholines; Phosphatidylserines; Piperidines; Piracetam; Plant Extracts; Plant Preparations; Vinca Alkaloids | 2003 |
Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats.
Topics: Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Candy; Diet; Eating; Energy Metabolism; Fatty Acids, Nonesterified; Female; Liver Glycogen; Male; Photoperiod; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Time Factors; Weight Loss | 2008 |