cocaine has been researched along with norcocaine in 118 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (18.64) | 18.7374 |
| 1990's | 49 (41.53) | 18.2507 |
| 2000's | 19 (16.10) | 29.6817 |
| 2010's | 25 (21.19) | 24.3611 |
| 2020's | 3 (2.54) | 2.80 |
| Authors | Studies |
|---|---|
| Bedford, JA; Borne, RF; Buelke, JL; Craig, CB; Hardin, TC; Kibbe, AH; Wilson, MC | 1 |
| Clarkson, CW; Crumb, WJ | 1 |
| Barber, DA; Tackett, RL | 1 |
| Alroy, J; Powers, JF; Shuster, L | 1 |
| Lau, CE | 1 |
| Fuller, B; Hickman, RM; James, MF; Janicki, P; Kambam, J; Kirsch, RE; Mets, B | 1 |
| de Zeeuw, RA; Ensing, JG; Racamy, C | 1 |
| Browne, S; Moore, C; Negrusz, A; Tebbett, I | 1 |
| Olsen, GD; Sandberg, JA | 2 |
| Falk, JL; Lau, CE; Ma, F | 2 |
| Boelsterli, UA; Bouis, P; Taccard, G | 1 |
| Boelsterli, UA; Bouis, P | 1 |
| Lajtha, A; Meisler, BE; Reith, ME | 1 |
| Lampert, BM; Stewart, JT | 1 |
| Braun, SB; DeVane, CL; Miller, RL; Simpkins, JW | 1 |
| Lajtha, A; Reith, ME | 1 |
| Callahan, SA; Latham, DJ; Lauriault, G; LeBelle, MJ | 1 |
| Palatý, V | 1 |
| Elliott, PJ; Nemeroff, CB; Rosen, GM | 1 |
| Colburn, RW; Hawks, RL; Kopin, IJ; Thoa, NB | 1 |
| Kloss, MW; Rauckman, EJ; Rosen, GM | 2 |
| Lallemant, AM; Thevenin, M | 1 |
| Freeman, RW; Harbison, RD; Teaf, CM | 1 |
| Evans, MA | 1 |
| Casey, E; Shuster, L; Welankiwar, SS | 1 |
| Bedford, JA; Borne, RF; Wilson, MC | 1 |
| Jones, BE; Risner, ME | 1 |
| Fozard, JR | 1 |
| Cavagnaro, J; Kloss, MW; Rauckman, EJ; Rosen, GM | 1 |
| Freeman, RW; Harbison, RD | 1 |
| Järbe, TU | 1 |
| Bedford, JA; Borne, RF; Nail, GL; Wilson, MC | 1 |
| Allen, AC; Erzouki, HK; Goldberg, SR; Newman, AH; Schindler, CW | 1 |
| Mets, B; Virag, L | 1 |
| Baum, I; Erzouki, HK; Goldberg, SR; Schindler, CW | 1 |
| Chow, HH; Mayersohn, M; Sukbuntherng, J; Walters, A | 1 |
| Bohman, VR; Little, BB; Roe, DA; Sobhi, S; Stettler, RW; Westfall, KL | 1 |
| Holsapple, MP; Jeong, TC; Jordan, SD; Matulka, RA; Yang, KH | 1 |
| Masten, S; Phillips, DL; Shiverick, KT; Tebbett, IR | 1 |
| Browne, S; Covert, R; Dusick, A; Moore, C; Negrusz, A; Tebbett, I | 1 |
| Edinboro, LE; Holsapple, MP; Kump, DF; Matulka, RA; Poklis, A | 1 |
| Klein, CL; Reynolds, M; Trudell, M; Zhu, N | 1 |
| Anday, EK; Goplerud, JM; Kurth, CD; Lien, R; Shaw, LM | 1 |
| Dempsey, DA; Ferriero, DM; Konkol, RJ; Murphey, LJ; Olsen, GD | 1 |
| Fukui, M; Igarashi, K; Kasuya, F; Nakajima, K; Nishikawa, M; Tatsuno, M; Tsuchihashi, H | 1 |
| Franks, JJ; Hickman, R; Janicki, PK; Kambam, JR; Mets, B; van der Watt, M | 1 |
| Covert, RF; Madden, JA; Schreiber, MD; Torgerson, LJ | 1 |
| D'Antoni, T; Mahone, PR; Scott, K; Sleggs, G; Woods, JR | 1 |
| Costa, LG; Tan, XX | 1 |
| Dewey, SL; Fowler, JS; Gatley, SJ; MacGregor, RR; Martin, T; Schlyer, DJ; Shea, CE; Volkow, ND; Wolf, AP; Yu, DW | 1 |
| Abraham, P; Boja, JW; Carroll, FI; Kopajtic, T; Kuhar, MJ; Lewin, AH; Yang, E | 1 |
| Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR; Walton, HS | 1 |
| Downing, JW; Henderson, GI; Johnson, RF; King, TS; Schenken, RS; Schenker, S; Yang, Y | 1 |
| Evans, JE; Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR | 1 |
| Konkol, RJ; Murphey, LJ; Olsen, GD | 1 |
| Jamdar, S; Mets, B; Virag, L | 1 |
| Bertholf, RL; Phillips, DL; Tebbett, IR | 1 |
| Logan, BK; Smirnow, D | 1 |
| Alburges, ME; Crouch, DJ; Moody, DE; Rollins, DE; Spanbauer, AC | 1 |
| Lau, CE; Ma, F; Zhang, J | 1 |
| Breen, P; Gurley, BJ; Light, KE; Nyamweya, NN | 1 |
| Bornheim, LM | 1 |
| Huttunen, P; MacDonald, E; Mahlakaarto, J; Pasanen, M; Ruskoaho, H | 1 |
| Hedaya, MA; Pan, WJ | 1 |
| Cooper, TB; Iso, A; Khan, K; Morishima, HO; Whittington, RA | 1 |
| Cooper, TB; Iso, A; Morishima, HO; Whittington, RA | 1 |
| Du, P; Johnson, KM; Kozikowski, AP; Roberti, M; Rondanin, R; Simoni, D; Wang, S | 1 |
| Diaz, J; Jamdar, S; Mets, B; Soo, E | 1 |
| Blair, IA; Diaz, J; Mets, B; Pantuck, C; Singh, G; Soo, E | 1 |
| Boelsterli, UA; Boess, F; Ndikum-Moffor, FM; Roberts, SM | 1 |
| Diaz, J; Jamdar, SC; Mets, B; Pantuck, CB | 1 |
| Foltz, RL; Moody, DE; Spanbauer, AC; Walsh, SL | 1 |
| Erickson, TB; Maggiore, JA; Negrusz, A; Shah, SM; Williams, RH | 1 |
| Bourland, JA; Hatab, MM; Hayes, EF; Kelly, RC; Sweeney, SA | 1 |
| Auriola, S; Juvonen, R; Konttila, J; Kulmala, L; Pasanen, M; Pellinen, P | 1 |
| de la Torre, R; Gonzalez, ML; Ladona, MG; Peter, RM; Rane, A | 1 |
| Falk, JL; Lau, CE; Simpao, A; Sun, L; Wang, Q | 1 |
| Lau, CE; Sun, L | 1 |
| Goldberg, SR; Schindler, CW; Zheng, JW | 1 |
| Kantak, KM | 1 |
| Kovacic, P | 1 |
| de Moraes Moreau, RL; Silva, OA; Valente-Campos, S; Yonamine, M | 1 |
| Akhavan, A; Festa, ED; Foltz, R; Lamm, L; Lin, SN; Niyomchai, T; Quiñones-Jenab, V | 1 |
| Coulter, C; Crompton, K; Moore, C | 1 |
| Hoelzle, C; Sachs, H; Scheufler, F; Thieme, D; Uhl, M | 1 |
| Feng, LI; Hsieh, YZ; Jen, HP; Su, HL | 1 |
| Bjergum, MW; Crow, FW; Langman, LJ; Williamson, CL | 1 |
| Bastos, ML; Carvalho, F; Carvalho, M; de Pinho, PG; Valente, MJ | 1 |
| Grivet, C; Hopfgartner, G; Kraemer, T; Porta, T; Varesio, E | 1 |
| Brim, RL; Collins, GT; Narasimhan, D; Nichols, J; Noon, KR; Sunahara, RK; Woods, JH | 1 |
| Huestis, MA; Ropero-Miller, JD; Stout, PR | 1 |
| Adamczyk, P; Bystrowska, B; Filip, M; Fuxe, K; Moniczewski, A; Zaniewska, M | 1 |
| Hou, S; Zhan, CG; Zhan, M; Zheng, F | 1 |
| Dulaurent, S; Gaulier, JM; Imbert, L; Lachâtre, G; Mercerolle, M; Morichon, J | 1 |
| Andrenyak, DM; Crystal, RG; De, BP; Evans, SM; Foltin, RW; Hicks, MJ; Janda, KD; Kaminsky, SM; Koob, GF; Lepherd, ML; Moody, DE; Ricart Arbona, RJ; Rosenberg, JB | 1 |
| Aroni, K; Fucci, N; Gambelunghe, C; Rossi, R | 1 |
| Kinsey, BM; Kosten, TR; Orson, FM; Ramakrishnan, M; Singh, RA | 1 |
| Hou, S; Zhan, CG; Zhan, M; Zheng, F; Zheng, X | 1 |
| Gareri, J; Koren, G; Poon, S; Walasek, P | 1 |
| Gonzalez, J; Hastedt, M; Pragst, F; Rubio, NC | 1 |
| Kotlinska, JH; Mielczarek, P; Raoof, H; Silberring, J; Stefanowicz, P; Suder, P; Szewczuk, Z | 1 |
| Anizan, S; Barnes, AJ; Concheiro, M; da Costa, JL; Ellefsen, KN; Gorelick, DA; Huestis, MA; Pirard, S | 1 |
| Aroni, K; Bacci, M; Fucci, N; Gambelunghe, C; Gili, A; Pascali, V; Rossi, R | 1 |
| Belitsky, ÍT; Fruchtengarten, LV; Loddi, S; Rodrigues de Oliveira, CD; Silveira, Gde O; Yonamine, M; Zucoloto, AD | 1 |
| Ito, Y; Kenjjou, N; Nakayama, H; Shigetoh, N | 1 |
| Chen, X; Ding, K; Zhan, CG; Zheng, F; Zheng, X; Zhou, Z | 1 |
| Franz, T; Musshoff, F; Sachs, H; Schwarz, G; Skopp, G; Thieme, D | 1 |
| Aggazzotti, G; Castiglioni, S; Fantuzzi, G; Predieri, G; Righi, E; Riva, F; Zuccato, E | 1 |
| Aranguren, M; Gorlelo, JC; Krumbiegel, F; Nagel, A; Poliansky, N; Pragst, F; Rubio, NC; Thurmann, D; Zytowski, E | 1 |
| Antunes, MV; Bastiani, MF; Bulcão, R; da Silva, ACC; de Lima Feltraco Lizot, L; Hahn, RZ; Linden, R; Perassolo, MS | 1 |
| Antunes, MV; Bastiani, MF; da Silva, ACC; Hahn, RZ; Linden, R; Lizot, LLF; Maurer, TF; Perassolo, MS | 1 |
| Gambier, N; Van Elsue, N; Warling, J; Yegles, M | 1 |
| Shang, L; Zhan, CG; Zheng, F; Zheng, X | 1 |
| Kirley, TL; Norman, AB | 1 |
| Chen, X; Hou, S; Shang, L; Zhan, CG; Zhan, M; Zheng, F | 1 |
2 review(s) available for cocaine and norcocaine
| Article | Year |
|---|---|
Cocaine metabolites in the neonate: potential for toxicity.
Topics: Butyrylcholinesterase; Central Nervous System Diseases; Cocaine; Female; Fetal Blood; Fever; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Neonatal Abstinence Syndrome; Pregnancy; Prospective Studies; Respiratory Distress Syndrome, Newborn | 1994 |
Anti-cocaine vaccines: antibody protection against relapse.
Topics: Animals; Antibodies, Monoclonal; Clinical Trials as Topic; Cocaine; Cocaine-Related Disorders; Hemocyanins; Humans; Secondary Prevention; Vaccination; Vaccines | 2003 |
1 trial(s) available for cocaine and norcocaine
| Article | Year |
|---|---|
Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, drug-user populations and surface-contaminated specimens.
Topics: Adolescent; Adult; Biotransformation; Cocaine; Environmental Exposure; Female; Forensic Toxicology; Guidelines as Topic; Hair; Humans; Illicit Drugs; Male; Middle Aged; Psychotropic Drugs; Substance Abuse Detection; Surface Properties; Tissue Distribution; United States; Young Adult | 2012 |
115 other study(ies) available for cocaine and norcocaine
| Article | Year |
|---|---|
Biological effects of cocaine derivatives I: Improved synthesis and pharmacological evaluation of norcocaine.
Topics: Animals; Body Temperature; Cocaine; Haplorhini; Macaca mulatta; Male; Respiration; Seizures | 1977 |
Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes.
Topics: Animals; Cocaine; Electrophysiology; Guinea Pigs; Heart; Myocardium; Sodium Channels | 1992 |
Hemodynamic effects of centrally administered, norcocaine in the rat.
Topics: Analysis of Variance; Animals; Cardiovascular Physiological Phenomena; Cardiovascular System; Cocaine; Dose-Response Relationship, Drug; Hemodynamics; Male; Pentobarbital; Random Allocation; Rats; Rats, Inbred WKY | 1992 |
Hepatic morphologic and biochemical changes induced by subacute cocaine administration in mice.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Ribosomes | 1992 |
Determination of cocaethylene, cocaine and their metabolites in rat serum microsamples by high-performance liquid chromatography, and its application to pharmacokinetic studies in rodents.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cocaine; Ethanol; Injections, Intraperitoneal; Male; Neurotransmitter Uptake Inhibitors; Rats | 1992 |
The effects of inhibition of plasma cholinesterase and hepatic microsomal enzyme activity on cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine blood levels in pigs.
Topics: Animals; Biotransformation; Cholinesterases; Cocaine; Half-Life; Male; Metabolic Clearance Rate; Microsomes, Liver; Swine; Tetraisopropylpyrophosphamide | 1992 |
A rapid gas chromatographic method for the fingerprinting of illicit cocaine samples.
Topics: Bridged Bicyclo Compounds; Chromatography, Gas; Cocaine; Cyclobutanes; Illicit Drugs; Time Factors | 1992 |
Determination of cocaine and its metabolites in brain tissue using high-flow solid-phase extraction columns and high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Female; Rabbits; Reproducibility of Results | 1992 |
Cocaine and metabolite concentrations in the fetal guinea pig after chronic maternal cocaine administration.
Topics: Amniotic Fluid; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Female; Fetal Blood; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Lidocaine; Maternal-Fetal Exchange; Pregnancy | 1992 |
Simultaneous determination of cocaine and its metabolites with caffeine in rat serum microsamples by high-performance liquid chromatography.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cocaine; Drug Stability; Male; Microchemistry; Rats | 1990 |
Microassay for the simultaneous determination of cocaine, norcocaine, benzoylecgonine and benzoylnorecgonine by high-performance liquid chromatography.
Topics: Amniotic Fluid; Animals; Chromatography, High Pressure Liquid; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Maternal-Fetal Exchange; Pregnancy | 1990 |
Determination of cocaine and norcocaine in plasma and cell cultures using high-performance liquid chromatography.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cocaine; Dogs; Drug Stability; Humans; Hydrogen-Ion Concentration; Rats | 1990 |
Modulation of cocaine metabolism in primary rat hepatocyte cultures: effects on irreversible binding and protein biosynthesis.
Topics: Analysis of Variance; Animals; Antimetabolites; Aroclors; Buthionine Sulfoximine; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorodiphenyl (54% Chlorine); Cocaine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Proteins; Pyridines; Rats; Rats, Inbred Strains | 1990 |
Locomotor effects of cocaine, cocaine congeners, and local anesthetics in mice.
Topics: Anesthetics, Local; Animals; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Intraventricular; Ion Channels; Male; Mice; Mice, Inbred BALB C; Motor Activity; Structure-Activity Relationship; Tetracaine | 1985 |
Determination of cocaine and selected metabolites in canine and human serum by reversed-phase high-performance liquid chromatography on coupled cyanopropyl and silica columns.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dogs; Humans; Spectrophotometry, Ultraviolet | 1989 |
Tissue distribution of cocaine in the pregnant rat.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Cocaine; Female; Fetus; Gestational Age; Injections, Intraperitoneal; Liver; Maternal-Fetal Exchange; Myocardium; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Tissue Distribution | 1989 |
Locomotor depression in mice by norcocaine does not involve central alpha 2-adrenergic or presynaptic dopamine receptors.
Topics: Animals; Clonidine; Cocaine; Depression, Chemical; Drug Interactions; Male; Mice; Mice, Inbred BALB C; Motor Activity; Receptors, Adrenergic, alpha; Receptors, Dopamine | 1986 |
Identification and determination of norcocaine in illicit cocaine and coca leaves by gas chromatography-mass spectrometry and high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Coca; Cocaine; Gas Chromatography-Mass Spectrometry; Illicit Drugs; Plants, Medicinal | 1988 |
Release of vesicular noradrenaline in the rat tail artery induced by cocaine.
Topics: Animals; Arteries; Calcium; Cocaine; Desipramine; Dose-Response Relationship, Drug; Male; Methoxyhydroxyphenylglycol; Microscopy, Electron; Monoamine Oxidase; Norepinephrine; Rats; Rats, Inbred Strains; Tail | 1988 |
A comparison of cocaine and its metabolite norcocaine: effects on locomotor activity.
Topics: Animals; Cocaine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Motor Activity; Rats; Rats, Inbred F344 | 1987 |
Norcocaine: a pharmacologically active metabolite of cocaine found in brain.
Topics: Animals; Brain; Chromatography, Ion Exchange; Cocaine; Gas Chromatography-Mass Spectrometry; Macaca mulatta; Norepinephrine; Rats; Rats, Inbred Strains; Synaptosomes | 1974 |
Biotransformation of norcocaine to norcocaine nitroxide by rat brain microsomes.
Topics: Animals; Biotransformation; Brain; Cocaine; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains | 1984 |
Influence of acid or alkaline treatment on tissue distribution and urinary excretion of (3H)-cocaine on acutely treated rats.
Topics: Ammonium Chloride; Animals; Bicarbonates; Brain Chemistry; Cocaine; Liver; Male; Rats; Sodium Bicarbonate; Tissue Distribution | 1980 |
Cocaine-induced hepatotoxicity: lipid peroxidation as a possible mechanism.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Lipid Peroxides; Male; Malondialdehyde; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital | 1984 |
Metabolic disposition and toxicity of cocaine.
Topics: Adolescent; Adult; Animals; Cocaine; Female; Humans; Liver Diseases; Male; Mice; Substance-Related Disorders | 1984 |
Metabolism of cocaine and norcocaine to N-hydroxynorcocaine.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme Inhibitors; Male; Mass Spectrometry; Mice; Microsomes | 1983 |
Comparative behavioral profile of cocaine and norcocaine in rats and monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Feeding Behavior; Food; Haplorhini; Macaca mulatta; Male; Motor Activity; Rats; Reinforcement Schedule; Self Administration; Species Specificity | 1980 |
Intravenous self-administration of cocaine and norcocaine by dogs.
Topics: Animals; Cocaine; Dextroamphetamine; Dogs; Infusions, Parenteral; Phenoxybenzamine; Pimozide; Self Administration; Time Factors | 1980 |
N-demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase.
Topics: Animals; Cocaine; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Microsomes, Liver; NADP; Oxygenases; Spectrophotometry, Ultraviolet | 1983 |
Differences between receptors for 5-hydroxytryptamine on autonomic neurones revealed by nor-(-)-cocaine.
Topics: Animals; Cocaine; Female; Guinea Pigs; Heart; Heart Rate; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Serotonin; Serotonin Antagonists | 1983 |
Involvement of FAD-containing monooxygenase in cocaine-induced hepatotoxicity.
Topics: Animals; Biotransformation; Castration; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Flavin-Adenine Dinucleotide; Male; Mice; Mice, Inbred C3H; Mixed Function Oxygenases; Oxidoreductases | 1982 |
The role of benzoylmethylecgonine in cocaine-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cocaine; Lidocaine; Male; Mice; Procaine; Rats | 1981 |
Cocaine cue in pigeons: time course studies and generalization to structurally related compounds (norcocaine, WIN 35,428 and 35,065-2) and (+)-amphetamine.
Topics: Animals; Cocaine; Columbidae; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Structure-Activity Relationship; Time Factors | 1981 |
Discriminative stimulus properties of cocaine, norcocaine, and N-allylnorcocaine.
Topics: Animals; Cocaine; Female; Generalization, Stimulus; Male; Prejudice; Rats | 1981 |
Effects of cocaine, cocaine metabolites and cocaine pyrolysis products on the hindbrain cardiac and respiratory centers of the rabbit.
Topics: Animals; Blood Pressure; Cardiovascular Agents; Cocaine; Female; Heart Rate; Injections, Intra-Arterial; Male; Rabbits; Respiration; Respiratory System Agents; Rhombencephalon | 1995 |
Lethal toxicity from equimolar infusions of cocaine and cocaine metabolites in conscious and anesthetized rats.
Topics: Animals; Cocaine; Hemodynamics; Male; Narcotics; Rats; Rats, Sprague-Dawley; Respiration; Seizures; Structure-Activity Relationship | 1995 |
Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats.
Topics: Animals; Cocaine; Electrocardiography; Electrophysiology; Hemodynamics; Infusions, Intravenous; Male; Rats; Structure-Activity Relationship | 1993 |
Quantitative determination of cocaine, cocaethylene (ethylcocaine), and metabolites in plasma and urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Kinetics; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
A new placental enzyme in the metabolism of cocaine: an in vitro animal model.
Topics: Animals; Biotransformation; Butyrylcholinesterase; Cocaine; Female; Isoflurophate; Microsomes; Models, Biological; Oxidoreductases, N-Demethylating; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley | 1995 |
Role of metabolism in cocaine-induced immunosuppression in splenocyte cultures from B6C3F1 female mice.
Topics: Animals; Antibody Formation; Cells, Cultured; Cocaine; Cytochrome P-450 Enzyme System; Erythrocytes; Female; Hepatitis, Animal; Immune Tolerance; Immunosuppression Therapy; Liver; Mice; Microsomes, Liver; Random Allocation; Sheep; Spleen | 1995 |
Stimulatory effects of cocaine and its metabolites on IM-9 human B-lymphoblastoid cells.
Topics: B-Lymphocytes; Cell Line; Chromatography, High Pressure Liquid; Cocaine; Drug Stability; Humans; Lymphocyte Activation; Tetradecanoylphorbol Acetate | 1995 |
Detection of cocaine, norcocaine, and cocaethylene in the meconium of premature neonates.
Topics: Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Premature; Male; Meconium; Pregnancy; Pregnancy Complications; Prospective Studies; Substance Abuse Detection; Urine | 1994 |
Disposition of cocaine and norcocaine in blood and tissues of B6C3F1 mice.
Topics: Animals; Cocaine; Diazinon; Esterases; Female; Gas Chromatography-Mass Spectrometry; Immunocompetence; Mice | 1994 |
(-)-Norcocaine.
Topics: Cocaine; Crystallization; Crystallography, X-Ray; Molecular Structure | 1994 |
Pharmacokinetics and effect of cocaine on cerebral blood flow in the newborn.
Topics: Animals; Animals, Newborn; Cerebrovascular Circulation; Cocaine; Models, Biological; Swine | 1993 |
The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS).
Topics: Chromatography, High Pressure Liquid; Cocaine; Evaluation Studies as Topic; Forensic Medicine; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Secondary Ion; Substance Abuse Detection | 1994 |
The effect of hepatectomy and plasma cholinesterase inhibition on cocaine metabolism and cardiovascular responses in pigs.
Topics: Animals; Cardiovascular System; Cholinesterase Inhibitors; Cholinesterases; Cocaine; Hemodynamics; Hepatectomy; Liver; Male; Osmolar Concentration; Swine; Tetraisopropylpyrophosphamide | 1994 |
Effects of cocaine, benzoylecgonine, and cocaine metabolites in cannulated pressurized fetal sheep cerebral arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Catheterization; Cerebral Arteries; Cocaine; Female; In Vitro Techniques; Pregnancy; Receptors, Adrenergic, alpha-1; Sheep; Vasoconstriction | 1994 |
Cocaine and metabolites in amniotic fluid may prolong fetal drug exposure.
Topics: Absorption; Amniotic Fluid; Animals; Cocaine; Deglutition; Female; Fetal Blood; Fetus; Meconium; Pregnancy; Sheep | 1994 |
Inhibition of muscarinic receptor-stimulated phosphoinositide metabolism by cocaine, norcocaine and cocaethylene in rat brain.
Topics: Animals; Brain Chemistry; Carbachol; Cerebral Cortex; Cocaine; Female; Male; Muscarinic Antagonists; Neurotransmitter Uptake Inhibitors; Parasympatholytics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Sprague-Dawley | 1994 |
Studies with differentially labeled [11C]cocaine, [11C]norcocaine, [11C]benzoylecgonine, and [11C]- and 4'-[18F]fluorococaine to probe the extent to which [11C]cocaine metabolites contribute to PET images of the baboon brain.
Topics: Animals; Blood; Brain; Carbon Radioisotopes; Cocaine; Female; Fluorine Radioisotopes; Kinetics; Papio; Tomography, Emission-Computed | 1994 |
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters | 1994 |
Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunoblotting; L-Lactate Dehydrogenase; Liver; Methylcholanthrene; Models, Biological; Porphyrins; Proadifen; Protein Biosynthesis | 1994 |
The transfer of cocaine and its metabolites across the term human placenta.
Topics: Biological Transport; Cocaine; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Placenta; Pregnancy | 1993 |
Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases | 1993 |
Quantitation of benzoylnorecgonine and other cocaine metabolites in meconium by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cocaine; Female; Humans; Infant, Newborn; Meconium; Pregnancy; Substance-Related Disorders | 1993 |
Determination of cocaine, norcocaine, benzoylecgonine and ecgonine methyl ester in rat plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Sprague-Dawley; Regression Analysis | 1996 |
Comparison of HPLC and GC-MS for measurement cocaine and metabolites in human urine.
Topics: Chromatography, High Pressure Liquid; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Urinalysis | 1996 |
Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS.
Topics: Alkylation; Amines; Biotransformation; Carboxylic Acids; Cocaine; Esterification; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Reference Standards; Solvents; Structure-Activity Relationship | 1996 |
Analysis of cocaine and its metabolites from biological specimens using solid-phase extraction and positive ion chemical ionization mass spectrometry.
Topics: Calibration; Chromatography; Cocaine; Dopamine Uptake Inhibitors; Humans; Mass Spectrometry; Narcotics; Reference Standards; Reproducibility of Results; Tissue Distribution | 1995 |
Determination of cocaine and its metabolites in serum microsamples by high-performance liquid chromatography and its application to pharmacokinetics in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Male; Narcotics; Rats; Rats, Sprague-Dawley | 1997 |
Pharmacokinetics of cocaine and metabolites following intragastric administration to ten-day-old rat pups.
Topics: Administration, Oral; Animals; Animals, Newborn; Area Under Curve; Cocaine; Dietary Fats; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Rats; Rats, Sprague-Dawley | 1998 |
Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoenzymes; Liver; Male; Mice; Narcotics; Phencyclidine; Phenobarbital | 1998 |
Norcocaine is a potent modulator of haemodynamic responses, plasma catecholamines and cardiac hormone release in conscious rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Catecholamines; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Heart Rate; Male; Protein Precursors; Rats; Rats, Sprague-Dawley | 1998 |
Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects.
Topics: Algorithms; Animals; Area Under Curve; Biotransformation; Blood Pressure; Brain Chemistry; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Ethanol; Heart Rate; Injections, Intravenous; Male; Rats; Rats, Wistar | 1999 |
Role of gender in the toxicity of norcocaine.
Topics: Animals; Blood Circulation; Blood Pressure; Cocaine; Female; Hypotension; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Sex Factors | 1999 |
The comparative toxicity of cocaine and its metabolites in conscious rats.
Topics: Animals; Blood Pressure; Cocaine; Female; Heart Rate; Rats; Rats, Sprague-Dawley | 1999 |
Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity.
Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Stereoisomerism | 1999 |
Cocaine pharmacodynamics after intravenous and oral administration in rats: relation to pharmacokinetics.
Topics: Administration, Oral; Animals; Biological Availability; Cocaine; Dopamine Uptake Inhibitors; Illicit Drugs; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 1999 |
Cocaine, norcocaine, ecgonine methylester and benzoylecgonine pharmacokinetics in the rat.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Half-Life; Male; Rats; Rats, Sprague-Dawley | 1999 |
Chronic continuous cocaine infusion in rats: effect on urine cocaine, ecgonine methylester and benzoylecgonine concentrations and bolus-dose cocaine pharmacokinetics.
Topics: Anesthetics, Local; Animals; Area Under Curve; Cocaine; Dose-Response Relationship, Drug; Half-Life; Infusions, Intravenous; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley | 2000 |
Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species.
Topics: Animals; Cell Respiration; Cocaine; Dopamine Uptake Inhibitors; In Vitro Techniques; Mice; Mice, Inbred ICR; Mitochondria; Reactive Oxygen Species; Rhodamines | 2000 |
A rapid, sensitive assay for cocaine and its metabolites in biological fluids using solid-phase extraction and high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Substance Abuse Detection | 2000 |
A gas chromatographic-positive ion chemical ionization-mass spectrometric method for determination of cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine in plasma: detection of norcocaine in plasma after oral administration of cocaine.
Topics: Administration, Oral; Cocaine; Gas Chromatography-Mass Spectrometry; Narcotics | 2000 |
Cocaine and its major metabolites in plasma and urine samples from patients in an urban emergency medicine setting.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Emergency Service, Hospital; Female; Gas Chromatography-Mass Spectrometry; Hospitals, Urban; Humans; Male; Middle Aged; Retrospective Studies; Substance Abuse Detection | 2000 |
Quantitation of cocaine, benzoylecgonine, cocaethylene, methylecgonine, and norcocaine in human hair by positive ion chemical ionization (PICI) gas chromatography-tandem mass spectrometry.
Topics: Biotransformation; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Reproducibility of Results; Substance Abuse Detection | 2000 |
Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Hydroxylation; In Vitro Techniques; Male; Mass Spectrometry; Mice; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Spectrophotometry, Ultraviolet; Steroid 16-alpha-Hydroxylase | 2000 |
Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression.
Topics: Adolescent; Adult; Aged; Aging; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Pregnancy | 2000 |
Contribution of the active metabolite, norcocaine, to cocaine's effects after intravenous and oral administration in rats: pharmacodynamics.
Topics: Administration, Oral; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement, Psychology | 2001 |
Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzoylecgonine, after intravenous and oral administration in rats.
Topics: Administration, Oral; Animals; Cocaine; Injections, Intravenous; Male; Models, Biological; Rats; Rats, Sprague-Dawley | 2001 |
Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys.
Topics: Animals; Blood Pressure; Cocaine; Heart Rate; Models, Animal; Saimiri | 2001 |
Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer.
Topics: Cocaine; Cocaine-Related Disorders; Electron Transport; Formaldehyde; Humans; Nitrogen Oxides; Oxidative Stress; Reactive Oxygen Species | 2005 |
Validation of a method to detect cocaine and its metabolites in nails by gas chromatography-mass spectrometry.
Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Nails; Reproducibility of Results; Substance Abuse Detection | 2006 |
Estrogen and progesterone affect cocaine pharmacokinetics in female rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Estrogens; Female; Mass Spectrometry; Motor Activity; Ovariectomy; Progesterone; Rats; Rats, Inbred F344; Time Factors | 2006 |
Determination of cocaine, benzoylecgonine, cocaethylene and norcocaine in human hair using solid-phase extraction and liquid chromatography with tandem mass spectrometric detection.
Topics: Chromatography, Liquid; Cocaine; Hair; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2007 |
Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination.
Topics: Cocaine; Discriminant Analysis; Dopamine Uptake Inhibitors; Drug Contamination; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Substance Abuse Detection | 2008 |
Determination of cocaine and its metabolites using cation-selective exhaustive injection and sweeping-MEKC.
Topics: Buffers; Cations; Chromatography, Micellar Electrokinetic Capillary; Cocaine; Humans; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Solvents; Time Factors | 2008 |
Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine.
Topics: Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2009 |
Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: application to the study of cocaine metabolism in human primary cultured re
Topics: Acute Kidney Injury; Cells, Cultured; Cocaine; Cocaine-Related Disorders; Gas Chromatography-Mass Spectrometry; Humans; Kidney Tubules, Proximal; Models, Biological | 2010 |
Single hair cocaine consumption monitoring by mass spectrometric imaging.
Topics: Cocaine; Hair; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.
Topics: Animals; Bacterial Proteins; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cocaine; Hydrolysis; Male; Rats; Rats, Sprague-Dawley; Rhodococcus; Tandem Mass Spectrometry | 2011 |
LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats.
Topics: Animals; Biotransformation; Brain; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Half-Life; Injections, Intravenous; Kidney; Liver; Male; Metabolic Clearance Rate; Myocardium; Rats; Rats, Wistar; Reproducibility of Results; Self Administration; Substance Withdrawal Syndrome; Tandem Mass Spectrometry; Tissue Distribution | 2012 |
Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.
Topics: Animals; Butyrylcholinesterase; CHO Cells; Cocaine; Cricetinae; Cricetulus; HEK293 Cells; Humans; Kinetics; Male; Metabolic Clearance Rate; Models, Molecular; Molecular Docking Simulation; Mutant Proteins; Rats; Rats, Sprague-Dawley | 2014 |
Development and validation of a single LC-MS/MS assay following SPE for simultaneous hair analysis of amphetamines, opiates, cocaine and metabolites.
Topics: Amphetamines; Analgesics, Opioid; Chromatography, Liquid; Cocaine; Forensic Toxicology; Hair; Humans; Limit of Detection; Male; Narcotics; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2014 |
Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Proteins; Female; Immunotherapy, Active; Macaca mulatta; Vaccination; Vaccines | 2014 |
A direct immersion solid-phase microextraction gas chromatography/mass spectrometry method for the simultaneous detection of levamisole and minor cocaine congeners in hair samples from chronic abusers.
Topics: Chronic Disease; Cocaine; Cocaine-Related Disorders; Gas Chromatography-Mass Spectrometry; Hair; Humans; Levamisole; Solid Phase Microextraction | 2014 |
Hapten optimization for cocaine vaccine with improved cocaine recognition.
Topics: Animals; Antibodies; Cocaine; Enzyme-Linked Immunosorbent Assay; Haptens; Male; Mice; Mice, Inbred BALB C; Vaccines | 2014 |
Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.
Topics: Animals; Butyrylcholinesterase; Catalysis; CHO Cells; Cocaine; Cocaine-Related Disorders; Cricetulus; Ethanol; HEK293 Cells; Humans; Hydrolysis; Kinetics; Male; Molecular Docking Simulation; Rats | 2014 |
Norcocaine in human hair as a biomarker of heavy cocaine use in a high risk population.
Topics: Biomarkers; Cocaine; Cocaine-Related Disorders; Hair; Humans; Narcotics; Predictive Value of Tests; Sensitivity and Specificity | 2014 |
Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios.
Topics: Acetaminophen; Acetone; Adolescent; Adult; Aged; Chromatography, Liquid; Coca; Cocaine; Cocaine-Related Disorders; Drug and Narcotic Control; Drug Contamination; Female; Forensic Toxicology; Hair; Humans; Levamisole; Lidocaine; Male; Mass Spectrometry; Mastication; Middle Aged; Plant Leaves; Pyrrolidines; Tea | 2015 |
Electrochemical simulation of cocaine metabolism-a step toward predictive toxicology for drugs of abuse.
Topics: Animals; Cocaine; Electrochemical Techniques; Illicit Drugs; Male; Microsomes, Liver; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2014 |
Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration.
Topics: Adult; Chromatography, Liquid; Cocaine; Dried Blood Spot Testing; Female; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intravenous; Male; Mass Spectrometry; Middle Aged; Reproducibility of Results; Sensitivity and Specificity | 2015 |
Norcocaine and cocaethylene distribution patterns in hair samples from light, moderate, and heavy cocaine users.
Topics: Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Limit of Detection; Male; Solid Phase Extraction; Substance Abuse Detection | 2017 |
Development of a method for the determination of cocaine, cocaethylene and norcocaine in human breast milk using liquid phase microextraction and gas chromatography-mass spectrometry.
Topics: Cocaine; Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Liquid Phase Microextraction; Milk, Human; Reproducibility of Results; Substance Abuse Detection | 2016 |
Fluorescence Immunoassay for Cocaine Detection.
Topics: Antibodies, Monoclonal; Benzopyrans; Cocaine; Fluorescence; Humans; Immunoassay; Indoles; Limit of Detection | 2016 |
A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood.
Topics: Animals; Chromatography, Liquid; Cocaine; Humans; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2017 |
Determination of hydroxy metabolites of cocaine in hair samples for proof of consumption.
Topics: Cocaine; Dopamine Uptake Inhibitors; Hair; Humans; Hydroxylation; Illicit Drugs; Limit of Detection; Substance Abuse Detection; Tandem Mass Spectrometry | 2018 |
Illicit drugs and pharmaceuticals in swimming pool waters.
Topics: Amphetamines; Carbamazepine; Chromatography, High Pressure Liquid; Cocaine; Environmental Monitoring; Humans; Ibuprofen; Illicit Drugs; Ketoprofen; Pharmaceutical Preparations; Solid Phase Extraction; Swimming Pools; Water Pollutants, Chemical | 2018 |
Discrimination between chewing of coca leaves or drinking of coca tea and smoking of "paco" (coca paste) by hair analysis. A preliminary study of possibilities and limitations.
Topics: Acetone; Adolescent; Adult; Biomarkers; Coca; Cocaine; Cocaine-Related Disorders; Female; Hair; Humans; Male; Mastication; Middle Aged; Plant Leaves; Pyrrolidines; Smoking; Substance Abuse Detection; Tea; Young Adult | 2019 |
Simultaneous determination of cocaine, ecgonine methyl ester, benzoylecgonine, cocaethylene and norcocaine in dried blood spots by ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Topics: Blood Stains; Chromatography, High Pressure Liquid; Cocaine; Hematocrit; Humans; Narcotics; Reproducibility of Results; Specimen Handling; Tandem Mass Spectrometry | 2019 |
Simultaneous Determination of Cocaine and Metabolites in Human Plasma Using Solid Phase Micro-Extraction Fiber Tips C18 and UPLC-MS/MS.
Topics: Amines; Chromatography, Liquid; Cocaine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Plasma; Solid Phase Microextraction; Substance Abuse Detection; Tandem Mass Spectrometry | 2020 |
AEME production in cocaine positive hair after thermal hair treatment.
Topics: Biomarkers; Cocaine; Cocaine-Related Disorders; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Hair Preparations; Humans; In Vitro Techniques; Narcotics; Substance Abuse Detection | 2019 |
In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Lethal Dose 50; Locomotion; Male; Mice | 2019 |
Ligand binding to a humanized anti-cocaine mAb measured by dye absorption spectroscopy.
Topics: Antibodies, Monoclonal; Cocaine; Coloring Agents; Fluorometry; Humans; Ligands; Spectrum Analysis | 2021 |
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine.
Topics: Cocaine; Ethanol; Kinetics | 2023 |