cocaine and norcocaine

cocaine has been researched along with norcocaine in 118 studies

Research

Studies (118)

TimeframeStudies, this research(%)All Research%
pre-199022 (18.64)18.7374
1990's49 (41.53)18.2507
2000's19 (16.10)29.6817
2010's25 (21.19)24.3611
2020's3 (2.54)2.80

Authors

AuthorsStudies
Bedford, JA; Borne, RF; Buelke, JL; Craig, CB; Hardin, TC; Kibbe, AH; Wilson, MC1
Clarkson, CW; Crumb, WJ1
Barber, DA; Tackett, RL1
Alroy, J; Powers, JF; Shuster, L1
Lau, CE1
Fuller, B; Hickman, RM; James, MF; Janicki, P; Kambam, J; Kirsch, RE; Mets, B1
de Zeeuw, RA; Ensing, JG; Racamy, C1
Browne, S; Moore, C; Negrusz, A; Tebbett, I1
Olsen, GD; Sandberg, JA2
Falk, JL; Lau, CE; Ma, F2
Boelsterli, UA; Bouis, P; Taccard, G1
Boelsterli, UA; Bouis, P1
Lajtha, A; Meisler, BE; Reith, ME1
Lampert, BM; Stewart, JT1
Braun, SB; DeVane, CL; Miller, RL; Simpkins, JW1
Lajtha, A; Reith, ME1
Callahan, SA; Latham, DJ; Lauriault, G; LeBelle, MJ1
Palatý, V1
Elliott, PJ; Nemeroff, CB; Rosen, GM1
Colburn, RW; Hawks, RL; Kopin, IJ; Thoa, NB1
Kloss, MW; Rauckman, EJ; Rosen, GM2
Lallemant, AM; Thevenin, M1
Freeman, RW; Harbison, RD; Teaf, CM1
Evans, MA1
Casey, E; Shuster, L; Welankiwar, SS1
Bedford, JA; Borne, RF; Wilson, MC1
Jones, BE; Risner, ME1
Fozard, JR1
Cavagnaro, J; Kloss, MW; Rauckman, EJ; Rosen, GM1
Freeman, RW; Harbison, RD1
Järbe, TU1
Bedford, JA; Borne, RF; Nail, GL; Wilson, MC1
Allen, AC; Erzouki, HK; Goldberg, SR; Newman, AH; Schindler, CW1
Mets, B; Virag, L1
Baum, I; Erzouki, HK; Goldberg, SR; Schindler, CW1
Chow, HH; Mayersohn, M; Sukbuntherng, J; Walters, A1
Bohman, VR; Little, BB; Roe, DA; Sobhi, S; Stettler, RW; Westfall, KL1
Holsapple, MP; Jeong, TC; Jordan, SD; Matulka, RA; Yang, KH1
Masten, S; Phillips, DL; Shiverick, KT; Tebbett, IR1
Browne, S; Covert, R; Dusick, A; Moore, C; Negrusz, A; Tebbett, I1
Edinboro, LE; Holsapple, MP; Kump, DF; Matulka, RA; Poklis, A1
Klein, CL; Reynolds, M; Trudell, M; Zhu, N1
Anday, EK; Goplerud, JM; Kurth, CD; Lien, R; Shaw, LM1
Dempsey, DA; Ferriero, DM; Konkol, RJ; Murphey, LJ; Olsen, GD1
Fukui, M; Igarashi, K; Kasuya, F; Nakajima, K; Nishikawa, M; Tatsuno, M; Tsuchihashi, H1
Franks, JJ; Hickman, R; Janicki, PK; Kambam, JR; Mets, B; van der Watt, M1
Covert, RF; Madden, JA; Schreiber, MD; Torgerson, LJ1
D'Antoni, T; Mahone, PR; Scott, K; Sleggs, G; Woods, JR1
Costa, LG; Tan, XX1
Dewey, SL; Fowler, JS; Gatley, SJ; MacGregor, RR; Martin, T; Schlyer, DJ; Shea, CE; Volkow, ND; Wolf, AP; Yu, DW1
Abraham, P; Boja, JW; Carroll, FI; Kopajtic, T; Kuhar, MJ; Lewin, AH; Yang, E1
Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR; Walton, HS1
Downing, JW; Henderson, GI; Johnson, RF; King, TS; Schenken, RS; Schenker, S; Yang, Y1
Evans, JE; Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR1
Konkol, RJ; Murphey, LJ; Olsen, GD1
Jamdar, S; Mets, B; Virag, L1
Bertholf, RL; Phillips, DL; Tebbett, IR1
Logan, BK; Smirnow, D1
Alburges, ME; Crouch, DJ; Moody, DE; Rollins, DE; Spanbauer, AC1
Lau, CE; Ma, F; Zhang, J1
Breen, P; Gurley, BJ; Light, KE; Nyamweya, NN1
Bornheim, LM1
Huttunen, P; MacDonald, E; Mahlakaarto, J; Pasanen, M; Ruskoaho, H1
Hedaya, MA; Pan, WJ1
Cooper, TB; Iso, A; Khan, K; Morishima, HO; Whittington, RA1
Cooper, TB; Iso, A; Morishima, HO; Whittington, RA1
Du, P; Johnson, KM; Kozikowski, AP; Roberti, M; Rondanin, R; Simoni, D; Wang, S1
Diaz, J; Jamdar, S; Mets, B; Soo, E1
Blair, IA; Diaz, J; Mets, B; Pantuck, C; Singh, G; Soo, E1
Boelsterli, UA; Boess, F; Ndikum-Moffor, FM; Roberts, SM1
Diaz, J; Jamdar, SC; Mets, B; Pantuck, CB1
Foltz, RL; Moody, DE; Spanbauer, AC; Walsh, SL1
Erickson, TB; Maggiore, JA; Negrusz, A; Shah, SM; Williams, RH1
Bourland, JA; Hatab, MM; Hayes, EF; Kelly, RC; Sweeney, SA1
Auriola, S; Juvonen, R; Konttila, J; Kulmala, L; Pasanen, M; Pellinen, P1
de la Torre, R; Gonzalez, ML; Ladona, MG; Peter, RM; Rane, A1
Falk, JL; Lau, CE; Simpao, A; Sun, L; Wang, Q1
Lau, CE; Sun, L1
Goldberg, SR; Schindler, CW; Zheng, JW1
Kantak, KM1
Kovacic, P1
de Moraes Moreau, RL; Silva, OA; Valente-Campos, S; Yonamine, M1
Akhavan, A; Festa, ED; Foltz, R; Lamm, L; Lin, SN; Niyomchai, T; Quiñones-Jenab, V1
Coulter, C; Crompton, K; Moore, C1
Hoelzle, C; Sachs, H; Scheufler, F; Thieme, D; Uhl, M1
Feng, LI; Hsieh, YZ; Jen, HP; Su, HL1
Bjergum, MW; Crow, FW; Langman, LJ; Williamson, CL1
Bastos, ML; Carvalho, F; Carvalho, M; de Pinho, PG; Valente, MJ1
Grivet, C; Hopfgartner, G; Kraemer, T; Porta, T; Varesio, E1
Brim, RL; Collins, GT; Narasimhan, D; Nichols, J; Noon, KR; Sunahara, RK; Woods, JH1
Huestis, MA; Ropero-Miller, JD; Stout, PR1
Adamczyk, P; Bystrowska, B; Filip, M; Fuxe, K; Moniczewski, A; Zaniewska, M1
Hou, S; Zhan, CG; Zhan, M; Zheng, F1
Dulaurent, S; Gaulier, JM; Imbert, L; Lachâtre, G; Mercerolle, M; Morichon, J1
Andrenyak, DM; Crystal, RG; De, BP; Evans, SM; Foltin, RW; Hicks, MJ; Janda, KD; Kaminsky, SM; Koob, GF; Lepherd, ML; Moody, DE; Ricart Arbona, RJ; Rosenberg, JB1
Aroni, K; Fucci, N; Gambelunghe, C; Rossi, R1
Kinsey, BM; Kosten, TR; Orson, FM; Ramakrishnan, M; Singh, RA1
Hou, S; Zhan, CG; Zhan, M; Zheng, F; Zheng, X1
Gareri, J; Koren, G; Poon, S; Walasek, P1
Gonzalez, J; Hastedt, M; Pragst, F; Rubio, NC1
Kotlinska, JH; Mielczarek, P; Raoof, H; Silberring, J; Stefanowicz, P; Suder, P; Szewczuk, Z1
Anizan, S; Barnes, AJ; Concheiro, M; da Costa, JL; Ellefsen, KN; Gorelick, DA; Huestis, MA; Pirard, S1
Aroni, K; Bacci, M; Fucci, N; Gambelunghe, C; Gili, A; Pascali, V; Rossi, R1
Belitsky, ÍT; Fruchtengarten, LV; Loddi, S; Rodrigues de Oliveira, CD; Silveira, Gde O; Yonamine, M; Zucoloto, AD1
Ito, Y; Kenjjou, N; Nakayama, H; Shigetoh, N1
Chen, X; Ding, K; Zhan, CG; Zheng, F; Zheng, X; Zhou, Z1
Franz, T; Musshoff, F; Sachs, H; Schwarz, G; Skopp, G; Thieme, D1
Aggazzotti, G; Castiglioni, S; Fantuzzi, G; Predieri, G; Righi, E; Riva, F; Zuccato, E1
Aranguren, M; Gorlelo, JC; Krumbiegel, F; Nagel, A; Poliansky, N; Pragst, F; Rubio, NC; Thurmann, D; Zytowski, E1
Antunes, MV; Bastiani, MF; Bulcão, R; da Silva, ACC; de Lima Feltraco Lizot, L; Hahn, RZ; Linden, R; Perassolo, MS1
Antunes, MV; Bastiani, MF; da Silva, ACC; Hahn, RZ; Linden, R; Lizot, LLF; Maurer, TF; Perassolo, MS1
Gambier, N; Van Elsue, N; Warling, J; Yegles, M1
Shang, L; Zhan, CG; Zheng, F; Zheng, X1
Kirley, TL; Norman, AB1
Chen, X; Hou, S; Shang, L; Zhan, CG; Zhan, M; Zheng, F1

Reviews

2 review(s) available for cocaine and norcocaine

ArticleYear
Cocaine metabolites in the neonate: potential for toxicity.
    Journal of child neurology, 1994, Volume: 9, Issue:3

    Topics: Butyrylcholinesterase; Central Nervous System Diseases; Cocaine; Female; Fetal Blood; Fever; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Neonatal Abstinence Syndrome; Pregnancy; Prospective Studies; Respiratory Distress Syndrome, Newborn

1994
Anti-cocaine vaccines: antibody protection against relapse.
    Expert opinion on pharmacotherapy, 2003, Volume: 4, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Clinical Trials as Topic; Cocaine; Cocaine-Related Disorders; Hemocyanins; Humans; Secondary Prevention; Vaccination; Vaccines

2003

Trials

1 trial(s) available for cocaine and norcocaine

ArticleYear
Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, drug-user populations and surface-contaminated specimens.
    Journal of analytical toxicology, 2012, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Biotransformation; Cocaine; Environmental Exposure; Female; Forensic Toxicology; Guidelines as Topic; Hair; Humans; Illicit Drugs; Male; Middle Aged; Psychotropic Drugs; Substance Abuse Detection; Surface Properties; Tissue Distribution; United States; Young Adult

2012

Other Studies

115 other study(ies) available for cocaine and norcocaine

ArticleYear
Biological effects of cocaine derivatives I: Improved synthesis and pharmacological evaluation of norcocaine.
    Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:1

    Topics: Animals; Body Temperature; Cocaine; Haplorhini; Macaca mulatta; Male; Respiration; Seizures

1977
Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Animals; Cocaine; Electrophysiology; Guinea Pigs; Heart; Myocardium; Sodium Channels

1992
Hemodynamic effects of centrally administered, norcocaine in the rat.
    Life sciences, 1992, Volume: 51, Issue:16

    Topics: Analysis of Variance; Animals; Cardiovascular Physiological Phenomena; Cardiovascular System; Cocaine; Dose-Response Relationship, Drug; Hemodynamics; Male; Pentobarbital; Random Allocation; Rats; Rats, Inbred WKY

1992
Hepatic morphologic and biochemical changes induced by subacute cocaine administration in mice.
    Toxicologic pathology, 1992, Volume: 20, Issue:1

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Ribosomes

1992
Determination of cocaethylene, cocaine and their metabolites in rat serum microsamples by high-performance liquid chromatography, and its application to pharmacokinetic studies in rodents.
    Journal of chromatography, 1992, Nov-06, Volume: 582, Issue:1-2

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cocaine; Ethanol; Injections, Intraperitoneal; Male; Neurotransmitter Uptake Inhibitors; Rats

1992
The effects of inhibition of plasma cholinesterase and hepatic microsomal enzyme activity on cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine blood levels in pigs.
    The Journal of laboratory and clinical medicine, 1992, Volume: 120, Issue:2

    Topics: Animals; Biotransformation; Cholinesterases; Cocaine; Half-Life; Male; Metabolic Clearance Rate; Microsomes, Liver; Swine; Tetraisopropylpyrophosphamide

1992
A rapid gas chromatographic method for the fingerprinting of illicit cocaine samples.
    Journal of forensic sciences, 1992, Volume: 37, Issue:2

    Topics: Bridged Bicyclo Compounds; Chromatography, Gas; Cocaine; Cyclobutanes; Illicit Drugs; Time Factors

1992
Determination of cocaine and its metabolites in brain tissue using high-flow solid-phase extraction columns and high-performance liquid chromatography.
    Forensic science international, 1992, Volume: 53, Issue:2

    Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Female; Rabbits; Reproducibility of Results

1992
Cocaine and metabolite concentrations in the fetal guinea pig after chronic maternal cocaine administration.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Amniotic Fluid; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Female; Fetal Blood; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Lidocaine; Maternal-Fetal Exchange; Pregnancy

1992
Simultaneous determination of cocaine and its metabolites with caffeine in rat serum microsamples by high-performance liquid chromatography.
    Journal of chromatography, 1990, Oct-26, Volume: 532, Issue:1

    Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cocaine; Drug Stability; Male; Microchemistry; Rats

1990
Microassay for the simultaneous determination of cocaine, norcocaine, benzoylecgonine and benzoylnorecgonine by high-performance liquid chromatography.
    Journal of chromatography, 1990, Jan-26, Volume: 525, Issue:1

    Topics: Amniotic Fluid; Animals; Chromatography, High Pressure Liquid; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Maternal-Fetal Exchange; Pregnancy

1990
Determination of cocaine and norcocaine in plasma and cell cultures using high-performance liquid chromatography.
    Journal of chromatography, 1990, Apr-06, Volume: 526, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cocaine; Dogs; Drug Stability; Humans; Hydrogen-Ion Concentration; Rats

1990
Modulation of cocaine metabolism in primary rat hepatocyte cultures: effects on irreversible binding and protein biosynthesis.
    Toxicology and applied pharmacology, 1990, Volume: 104, Issue:3

    Topics: Analysis of Variance; Animals; Antimetabolites; Aroclors; Buthionine Sulfoximine; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorodiphenyl (54% Chlorine); Cocaine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Proteins; Pyridines; Rats; Rats, Inbred Strains

1990
Locomotor effects of cocaine, cocaine congeners, and local anesthetics in mice.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

    Topics: Anesthetics, Local; Animals; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Intraventricular; Ion Channels; Male; Mice; Mice, Inbred BALB C; Motor Activity; Structure-Activity Relationship; Tetracaine

1985
Determination of cocaine and selected metabolites in canine and human serum by reversed-phase high-performance liquid chromatography on coupled cyanopropyl and silica columns.
    Journal of chromatography, 1989, Oct-27, Volume: 495

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dogs; Humans; Spectrophotometry, Ultraviolet

1989
Tissue distribution of cocaine in the pregnant rat.
    Life sciences, 1989, Volume: 45, Issue:14

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Cocaine; Female; Fetus; Gestational Age; Injections, Intraperitoneal; Liver; Maternal-Fetal Exchange; Myocardium; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Tissue Distribution

1989
Locomotor depression in mice by norcocaine does not involve central alpha 2-adrenergic or presynaptic dopamine receptors.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:2

    Topics: Animals; Clonidine; Cocaine; Depression, Chemical; Drug Interactions; Male; Mice; Mice, Inbred BALB C; Motor Activity; Receptors, Adrenergic, alpha; Receptors, Dopamine

1986
Identification and determination of norcocaine in illicit cocaine and coca leaves by gas chromatography-mass spectrometry and high-performance liquid chromatography.
    The Analyst, 1988, Volume: 113, Issue:8

    Topics: Chromatography, High Pressure Liquid; Coca; Cocaine; Gas Chromatography-Mass Spectrometry; Illicit Drugs; Plants, Medicinal

1988
Release of vesicular noradrenaline in the rat tail artery induced by cocaine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 338, Issue:5

    Topics: Animals; Arteries; Calcium; Cocaine; Desipramine; Dose-Response Relationship, Drug; Male; Methoxyhydroxyphenylglycol; Microscopy, Electron; Monoamine Oxidase; Norepinephrine; Rats; Rats, Inbred Strains; Tail

1988
A comparison of cocaine and its metabolite norcocaine: effects on locomotor activity.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:3

    Topics: Animals; Cocaine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Motor Activity; Rats; Rats, Inbred F344

1987
Norcocaine: a pharmacologically active metabolite of cocaine found in brain.
    Life sciences, 1974, Dec-15, Volume: 15, Issue:12

    Topics: Animals; Brain; Chromatography, Ion Exchange; Cocaine; Gas Chromatography-Mass Spectrometry; Macaca mulatta; Norepinephrine; Rats; Rats, Inbred Strains; Synaptosomes

1974
Biotransformation of norcocaine to norcocaine nitroxide by rat brain microsomes.
    Psychopharmacology, 1984, Volume: 84, Issue:2

    Topics: Animals; Biotransformation; Brain; Cocaine; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains

1984
Influence of acid or alkaline treatment on tissue distribution and urinary excretion of (3H)-cocaine on acutely treated rats.
    Clinical toxicology, 1980, Volume: 16, Issue:2

    Topics: Ammonium Chloride; Animals; Bicarbonates; Brain Chemistry; Cocaine; Liver; Male; Rats; Sodium Bicarbonate; Tissue Distribution

1980
Cocaine-induced hepatotoxicity: lipid peroxidation as a possible mechanism.
    Drug and chemical toxicology, 1984, Volume: 7, Issue:4

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Lipid Peroxides; Male; Malondialdehyde; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital

1984
Metabolic disposition and toxicity of cocaine.
    Medicine and law, 1984, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Animals; Cocaine; Female; Humans; Liver Diseases; Male; Mice; Substance-Related Disorders

1984
Metabolism of cocaine and norcocaine to N-hydroxynorcocaine.
    Biochemical pharmacology, 1983, Oct-15, Volume: 32, Issue:20

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme Inhibitors; Male; Mass Spectrometry; Mice; Microsomes

1983
Comparative behavioral profile of cocaine and norcocaine in rats and monkeys.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:1

    Topics: Animals; Behavior, Animal; Cocaine; Feeding Behavior; Food; Haplorhini; Macaca mulatta; Male; Motor Activity; Rats; Reinforcement Schedule; Self Administration; Species Specificity

1980
Intravenous self-administration of cocaine and norcocaine by dogs.
    Psychopharmacology, 1980, Volume: 71, Issue:1

    Topics: Animals; Cocaine; Dextroamphetamine; Dogs; Infusions, Parenteral; Phenoxybenzamine; Pimozide; Self Administration; Time Factors

1980
N-demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase.
    Molecular pharmacology, 1983, Volume: 23, Issue:2

    Topics: Animals; Cocaine; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Microsomes, Liver; NADP; Oxygenases; Spectrophotometry, Ultraviolet

1983
Differences between receptors for 5-hydroxytryptamine on autonomic neurones revealed by nor-(-)-cocaine.
    Journal of autonomic pharmacology, 1983, Volume: 3, Issue:1

    Topics: Animals; Cocaine; Female; Guinea Pigs; Heart; Heart Rate; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Serotonin; Serotonin Antagonists

1983
Involvement of FAD-containing monooxygenase in cocaine-induced hepatotoxicity.
    Toxicology and applied pharmacology, 1982, Jun-15, Volume: 64, Issue:1

    Topics: Animals; Biotransformation; Castration; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Flavin-Adenine Dinucleotide; Male; Mice; Mice, Inbred C3H; Mixed Function Oxygenases; Oxidoreductases

1982
The role of benzoylmethylecgonine in cocaine-induced hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:2

    Topics: Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cocaine; Lidocaine; Male; Mice; Procaine; Rats

1981
Cocaine cue in pigeons: time course studies and generalization to structurally related compounds (norcocaine, WIN 35,428 and 35,065-2) and (+)-amphetamine.
    British journal of pharmacology, 1981, Volume: 73, Issue:4

    Topics: Animals; Cocaine; Columbidae; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Structure-Activity Relationship; Time Factors

1981
Discriminative stimulus properties of cocaine, norcocaine, and N-allylnorcocaine.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:1

    Topics: Animals; Cocaine; Female; Generalization, Stimulus; Male; Prejudice; Rats

1981
Effects of cocaine, cocaine metabolites and cocaine pyrolysis products on the hindbrain cardiac and respiratory centers of the rabbit.
    Life sciences, 1995, Volume: 57, Issue:20

    Topics: Animals; Blood Pressure; Cardiovascular Agents; Cocaine; Female; Heart Rate; Injections, Intra-Arterial; Male; Rabbits; Respiration; Respiratory System Agents; Rhombencephalon

1995
Lethal toxicity from equimolar infusions of cocaine and cocaine metabolites in conscious and anesthetized rats.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:5

    Topics: Animals; Cocaine; Hemodynamics; Male; Narcotics; Rats; Rats, Sprague-Dawley; Respiration; Seizures; Structure-Activity Relationship

1995
Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4

    Topics: Animals; Cocaine; Electrocardiography; Electrophysiology; Hemodynamics; Infusions, Intravenous; Male; Rats; Structure-Activity Relationship

1993
Quantitative determination of cocaine, cocaethylene (ethylcocaine), and metabolites in plasma and urine by high-performance liquid chromatography.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:7

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Kinetics; Male; Rats; Rats, Sprague-Dawley; Time Factors

1995
A new placental enzyme in the metabolism of cocaine: an in vitro animal model.
    American journal of obstetrics and gynecology, 1995, Volume: 172, Issue:5

    Topics: Animals; Biotransformation; Butyrylcholinesterase; Cocaine; Female; Isoflurophate; Microsomes; Models, Biological; Oxidoreductases, N-Demethylating; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley

1995
Role of metabolism in cocaine-induced immunosuppression in splenocyte cultures from B6C3F1 female mice.
    Immunopharmacology, 1995, Volume: 29, Issue:1

    Topics: Animals; Antibody Formation; Cells, Cultured; Cocaine; Cytochrome P-450 Enzyme System; Erythrocytes; Female; Hepatitis, Animal; Immune Tolerance; Immunosuppression Therapy; Liver; Mice; Microsomes, Liver; Random Allocation; Sheep; Spleen

1995
Stimulatory effects of cocaine and its metabolites on IM-9 human B-lymphoblastoid cells.
    International journal of immunopharmacology, 1995, Volume: 17, Issue:1

    Topics: B-Lymphocytes; Cell Line; Chromatography, High Pressure Liquid; Cocaine; Drug Stability; Humans; Lymphocyte Activation; Tetradecanoylphorbol Acetate

1995
Detection of cocaine, norcocaine, and cocaethylene in the meconium of premature neonates.
    Journal of forensic sciences, 1994, Volume: 39, Issue:6

    Topics: Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Premature; Male; Meconium; Pregnancy; Pregnancy Complications; Prospective Studies; Substance Abuse Detection; Urine

1994
Disposition of cocaine and norcocaine in blood and tissues of B6C3F1 mice.
    Journal of analytical toxicology, 1994, Volume: 18, Issue:6

    Topics: Animals; Cocaine; Diazinon; Esterases; Female; Gas Chromatography-Mass Spectrometry; Immunocompetence; Mice

1994
(-)-Norcocaine.
    Acta crystallographica. Section C, Crystal structure communications, 1994, Dec-15, Volume: 50 ( Pt 12)

    Topics: Cocaine; Crystallization; Crystallography, X-Ray; Molecular Structure

1994
Pharmacokinetics and effect of cocaine on cerebral blood flow in the newborn.
    Developmental pharmacology and therapeutics, 1993, Volume: 20, Issue:1-2

    Topics: Animals; Animals, Newborn; Cerebrovascular Circulation; Cocaine; Models, Biological; Swine

1993
The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS).
    Forensic science international, 1994, Jun-10, Volume: 66, Issue:3

    Topics: Chromatography, High Pressure Liquid; Cocaine; Evaluation Studies as Topic; Forensic Medicine; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Secondary Ion; Substance Abuse Detection

1994
The effect of hepatectomy and plasma cholinesterase inhibition on cocaine metabolism and cardiovascular responses in pigs.
    The Journal of laboratory and clinical medicine, 1994, Volume: 124, Issue:5

    Topics: Animals; Cardiovascular System; Cholinesterase Inhibitors; Cholinesterases; Cocaine; Hemodynamics; Hepatectomy; Liver; Male; Osmolar Concentration; Swine; Tetraisopropylpyrophosphamide

1994
Effects of cocaine, benzoylecgonine, and cocaine metabolites in cannulated pressurized fetal sheep cerebral arteries.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Catheterization; Cerebral Arteries; Cocaine; Female; In Vitro Techniques; Pregnancy; Receptors, Adrenergic, alpha-1; Sheep; Vasoconstriction

1994
Cocaine and metabolites in amniotic fluid may prolong fetal drug exposure.
    American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:2

    Topics: Absorption; Amniotic Fluid; Animals; Cocaine; Deglutition; Female; Fetal Blood; Fetus; Meconium; Pregnancy; Sheep

1994
Inhibition of muscarinic receptor-stimulated phosphoinositide metabolism by cocaine, norcocaine and cocaethylene in rat brain.
    Brain research. Developmental brain research, 1994, May-13, Volume: 79, Issue:1

    Topics: Animals; Brain Chemistry; Carbachol; Cerebral Cortex; Cocaine; Female; Male; Muscarinic Antagonists; Neurotransmitter Uptake Inhibitors; Parasympatholytics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Sprague-Dawley

1994
Studies with differentially labeled [11C]cocaine, [11C]norcocaine, [11C]benzoylecgonine, and [11C]- and 4'-[18F]fluorococaine to probe the extent to which [11C]cocaine metabolites contribute to PET images of the baboon brain.
    Journal of neurochemistry, 1994, Volume: 62, Issue:3

    Topics: Animals; Blood; Brain; Carbon Radioisotopes; Cocaine; Female; Fluorine Radioisotopes; Kinetics; Papio; Tomography, Emission-Computed

1994
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.
    Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8

    Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters

1994
Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450.
    Toxicology and applied pharmacology, 1994, Volume: 125, Issue:2

    Topics: Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunoblotting; L-Lactate Dehydrogenase; Liver; Methylcholanthrene; Models, Biological; Porphyrins; Proadifen; Protein Biosynthesis

1994
The transfer of cocaine and its metabolites across the term human placenta.
    Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:3

    Topics: Biological Transport; Cocaine; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Placenta; Pregnancy

1993
Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.
    Pharmacology, 1993, Volume: 46, Issue:5

    Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases

1993
Quantitation of benzoylnorecgonine and other cocaine metabolites in meconium by high-performance liquid chromatography.
    Journal of chromatography, 1993, Apr-02, Volume: 613, Issue:2

    Topics: Chromatography, High Pressure Liquid; Cocaine; Female; Humans; Infant, Newborn; Meconium; Pregnancy; Substance-Related Disorders

1993
Determination of cocaine, norcocaine, benzoylecgonine and ecgonine methyl ester in rat plasma by high-performance liquid chromatography with ultraviolet detection.
    Journal of chromatography. B, Biomedical applications, 1996, Jun-07, Volume: 681, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Sprague-Dawley; Regression Analysis

1996
Comparison of HPLC and GC-MS for measurement cocaine and metabolites in human urine.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:5

    Topics: Chromatography, High Pressure Liquid; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Urinalysis

1996
Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: Alkylation; Amines; Biotransformation; Carboxylic Acids; Cocaine; Esterification; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Reference Standards; Solvents; Structure-Activity Relationship

1996
Analysis of cocaine and its metabolites from biological specimens using solid-phase extraction and positive ion chemical ionization mass spectrometry.
    Journal of analytical toxicology, 1995, Volume: 19, Issue:6

    Topics: Calibration; Chromatography; Cocaine; Dopamine Uptake Inhibitors; Humans; Mass Spectrometry; Narcotics; Reference Standards; Reproducibility of Results; Tissue Distribution

1995
Determination of cocaine and its metabolites in serum microsamples by high-performance liquid chromatography and its application to pharmacokinetics in rats.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Jun-06, Volume: 693, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Male; Narcotics; Rats; Rats, Sprague-Dawley

1997
Pharmacokinetics of cocaine and metabolites following intragastric administration to ten-day-old rat pups.
    Pharmaceutical research, 1998, Volume: 15, Issue:3

    Topics: Administration, Oral; Animals; Animals, Newborn; Area Under Curve; Cocaine; Dietary Fats; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Rats; Rats, Sprague-Dawley

1998
Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity.
    Toxicology and applied pharmacology, 1998, Volume: 150, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoenzymes; Liver; Male; Mice; Narcotics; Phencyclidine; Phenobarbital

1998
Norcocaine is a potent modulator of haemodynamic responses, plasma catecholamines and cardiac hormone release in conscious rats.
    Toxicology, 1998, Jul-03, Volume: 128, Issue:2

    Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Catecholamines; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Heart Rate; Male; Protein Precursors; Rats; Rats, Sprague-Dawley

1998
Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects.
    Journal of pharmaceutical sciences, 1999, Volume: 88, Issue:4

    Topics: Algorithms; Animals; Area Under Curve; Biotransformation; Blood Pressure; Brain Chemistry; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Ethanol; Heart Rate; Injections, Intravenous; Male; Rats; Rats, Wistar

1999
Role of gender in the toxicity of norcocaine.
    The Journal of laboratory and clinical medicine, 1999, Volume: 133, Issue:6

    Topics: Animals; Blood Circulation; Blood Pressure; Cocaine; Female; Hypotension; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Sex Factors

1999
The comparative toxicity of cocaine and its metabolites in conscious rats.
    Anesthesiology, 1999, Volume: 90, Issue:6

    Topics: Animals; Blood Pressure; Cocaine; Female; Heart Rate; Rats; Rats, Sprague-Dawley

1999
Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity.
    Bioorganic & medicinal chemistry letters, 1999, Jul-05, Volume: 9, Issue:13

    Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Stereoisomerism

1999
Cocaine pharmacodynamics after intravenous and oral administration in rats: relation to pharmacokinetics.
    Psychopharmacology, 1999, Volume: 144, Issue:4

    Topics: Administration, Oral; Animals; Biological Availability; Cocaine; Dopamine Uptake Inhibitors; Illicit Drugs; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule

1999
Cocaine, norcocaine, ecgonine methylester and benzoylecgonine pharmacokinetics in the rat.
    Life sciences, 1999, Volume: 65, Issue:12

    Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Half-Life; Male; Rats; Rats, Sprague-Dawley

1999
Chronic continuous cocaine infusion in rats: effect on urine cocaine, ecgonine methylester and benzoylecgonine concentrations and bolus-dose cocaine pharmacokinetics.
    The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:4

    Topics: Anesthetics, Local; Animals; Area Under Curve; Cocaine; Dose-Response Relationship, Drug; Half-Life; Infusions, Intravenous; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley

2000
Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species.
    Biochemical pharmacology, 2000, Sep-01, Volume: 60, Issue:5

    Topics: Animals; Cell Respiration; Cocaine; Dopamine Uptake Inhibitors; In Vitro Techniques; Mice; Mice, Inbred ICR; Mitochondria; Reactive Oxygen Species; Rhodamines

2000
A rapid, sensitive assay for cocaine and its metabolites in biological fluids using solid-phase extraction and high-performance liquid chromatography.
    Journal of analytical toxicology, 2000, Volume: 24, Issue:6

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Substance Abuse Detection

2000
A gas chromatographic-positive ion chemical ionization-mass spectrometric method for determination of cocaine, benzoylecgonine, ecgonine methyl ester, and norcocaine in plasma: detection of norcocaine in plasma after oral administration of cocaine.
    Journal of analytical toxicology, 2000, Volume: 24, Issue:6

    Topics: Administration, Oral; Cocaine; Gas Chromatography-Mass Spectrometry; Narcotics

2000
Cocaine and its major metabolites in plasma and urine samples from patients in an urban emergency medicine setting.
    Journal of analytical toxicology, 2000, Volume: 24, Issue:7

    Topics: Adult; Cocaine; Cocaine-Related Disorders; Emergency Service, Hospital; Female; Gas Chromatography-Mass Spectrometry; Hospitals, Urban; Humans; Male; Middle Aged; Retrospective Studies; Substance Abuse Detection

2000
Quantitation of cocaine, benzoylecgonine, cocaethylene, methylecgonine, and norcocaine in human hair by positive ion chemical ionization (PICI) gas chromatography-tandem mass spectrometry.
    Journal of analytical toxicology, 2000, Volume: 24, Issue:7

    Topics: Biotransformation; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Reproducibility of Results; Substance Abuse Detection

2000
Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.
    Archives of toxicology, 2000, Volume: 74, Issue:9

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Hydroxylation; In Vitro Techniques; Male; Mass Spectrometry; Mice; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Spectrophotometry, Ultraviolet; Steroid 16-alpha-Hydroxylase

2000
Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression.
    Life sciences, 2000, Dec-15, Volume: 68, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Pregnancy

2000
Contribution of the active metabolite, norcocaine, to cocaine's effects after intravenous and oral administration in rats: pharmacodynamics.
    Psychopharmacology, 2001, Volume: 153, Issue:3

    Topics: Administration, Oral; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement, Psychology

2001
Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzoylecgonine, after intravenous and oral administration in rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:9

    Topics: Administration, Oral; Animals; Cocaine; Injections, Intravenous; Male; Models, Biological; Rats; Rats, Sprague-Dawley

2001
Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys.
    European journal of pharmacology, 2001, Nov-09, Volume: 431, Issue:1

    Topics: Animals; Blood Pressure; Cocaine; Heart Rate; Models, Animal; Saimiri

2001
Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer.
    Medical hypotheses, 2005, Volume: 64, Issue:2

    Topics: Cocaine; Cocaine-Related Disorders; Electron Transport; Formaldehyde; Humans; Nitrogen Oxides; Oxidative Stress; Reactive Oxygen Species

2005
Validation of a method to detect cocaine and its metabolites in nails by gas chromatography-mass spectrometry.
    Forensic science international, 2006, Jun-02, Volume: 159, Issue:2-3

    Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Nails; Reproducibility of Results; Substance Abuse Detection

2006
Estrogen and progesterone affect cocaine pharmacokinetics in female rats.
    Brain research bulletin, 2006, Jan-30, Volume: 68, Issue:5

    Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Estrogens; Female; Mass Spectrometry; Motor Activity; Ovariectomy; Progesterone; Rats; Rats, Inbred F344; Time Factors

2006
Determination of cocaine, benzoylecgonine, cocaethylene and norcocaine in human hair using solid-phase extraction and liquid chromatography with tandem mass spectrometric detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-15, Volume: 859, Issue:2

    Topics: Chromatography, Liquid; Cocaine; Hair; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry

2007
Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination.
    Forensic science international, 2008, Mar-21, Volume: 176, Issue:1

    Topics: Cocaine; Discriminant Analysis; Dopamine Uptake Inhibitors; Drug Contamination; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Substance Abuse Detection

2008
Determination of cocaine and its metabolites using cation-selective exhaustive injection and sweeping-MEKC.
    Electrophoresis, 2008, Volume: 29, Issue:20

    Topics: Buffers; Cations; Chromatography, Micellar Electrokinetic Capillary; Cocaine; Humans; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Solvents; Time Factors

2008
Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine.
    Journal of analytical toxicology, 2009, Volume: 33, Issue:8

    Topics: Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry

2009
Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: application to the study of cocaine metabolism in human primary cultured re
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Nov-15, Volume: 878, Issue:30

    Topics: Acute Kidney Injury; Cells, Cultured; Cocaine; Cocaine-Related Disorders; Gas Chromatography-Mass Spectrometry; Humans; Kidney Tubules, Proximal; Models, Biological

2010
Single hair cocaine consumption monitoring by mass spectrometric imaging.
    Analytical chemistry, 2011, Jun-01, Volume: 83, Issue:11

    Topics: Cocaine; Hair; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.
    Molecular pharmacology, 2011, Volume: 80, Issue:6

    Topics: Animals; Bacterial Proteins; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cocaine; Hydrolysis; Male; Rats; Rats, Sprague-Dawley; Rhodococcus; Tandem Mass Spectrometry

2011
LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:6

    Topics: Animals; Biotransformation; Brain; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Half-Life; Injections, Intravenous; Kidney; Liver; Male; Metabolic Clearance Rate; Myocardium; Rats; Rats, Wistar; Reproducibility of Results; Self Administration; Substance Withdrawal Syndrome; Tandem Mass Spectrometry; Tissue Distribution

2012
Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.
    The Biochemical journal, 2014, Jan-01, Volume: 457, Issue:1

    Topics: Animals; Butyrylcholinesterase; CHO Cells; Cocaine; Cricetinae; Cricetulus; HEK293 Cells; Humans; Kinetics; Male; Metabolic Clearance Rate; Models, Molecular; Molecular Docking Simulation; Mutant Proteins; Rats; Rats, Sprague-Dawley

2014
Development and validation of a single LC-MS/MS assay following SPE for simultaneous hair analysis of amphetamines, opiates, cocaine and metabolites.
    Forensic science international, 2014, Volume: 234

    Topics: Amphetamines; Analgesics, Opioid; Chromatography, Liquid; Cocaine; Forensic Toxicology; Hair; Humans; Limit of Detection; Male; Narcotics; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry

2014
Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine.
    Human gene therapy. Clinical development, 2014, Volume: 25, Issue:1

    Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Proteins; Female; Immunotherapy, Active; Macaca mulatta; Vaccination; Vaccines

2014
A direct immersion solid-phase microextraction gas chromatography/mass spectrometry method for the simultaneous detection of levamisole and minor cocaine congeners in hair samples from chronic abusers.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:6

    Topics: Chronic Disease; Cocaine; Cocaine-Related Disorders; Gas Chromatography-Mass Spectrometry; Hair; Humans; Levamisole; Solid Phase Microextraction

2014
Hapten optimization for cocaine vaccine with improved cocaine recognition.
    Chemical biology & drug design, 2014, Volume: 84, Issue:3

    Topics: Animals; Antibodies; Cocaine; Enzyme-Linked Immunosorbent Assay; Haptens; Male; Mice; Mice, Inbred BALB C; Vaccines

2014
Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.
    The Biochemical journal, 2014, Jun-15, Volume: 460, Issue:3

    Topics: Animals; Butyrylcholinesterase; Catalysis; CHO Cells; Cocaine; Cocaine-Related Disorders; Cricetulus; Ethanol; HEK293 Cells; Humans; Hydrolysis; Kinetics; Male; Molecular Docking Simulation; Rats

2014
Norcocaine in human hair as a biomarker of heavy cocaine use in a high risk population.
    Forensic science international, 2014, Volume: 241

    Topics: Biomarkers; Cocaine; Cocaine-Related Disorders; Hair; Humans; Narcotics; Predictive Value of Tests; Sensitivity and Specificity

2014
Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios.
    International journal of legal medicine, 2015, Volume: 129, Issue:1

    Topics: Acetaminophen; Acetone; Adolescent; Adult; Aged; Chromatography, Liquid; Coca; Cocaine; Cocaine-Related Disorders; Drug and Narcotic Control; Drug Contamination; Female; Forensic Toxicology; Hair; Humans; Levamisole; Lidocaine; Male; Mass Spectrometry; Mastication; Middle Aged; Plant Leaves; Pyrrolidines; Tea

2015
Electrochemical simulation of cocaine metabolism-a step toward predictive toxicology for drugs of abuse.
    European journal of mass spectrometry (Chichester, England), 2014, Volume: 20, Issue:4

    Topics: Animals; Cocaine; Electrochemical Techniques; Illicit Drugs; Male; Microsomes, Liver; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization

2014
Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration.
    Bioanalysis, 2015, Volume: 7, Issue:16

    Topics: Adult; Chromatography, Liquid; Cocaine; Dried Blood Spot Testing; Female; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intravenous; Male; Mass Spectrometry; Middle Aged; Reproducibility of Results; Sensitivity and Specificity

2015
Norcocaine and cocaethylene distribution patterns in hair samples from light, moderate, and heavy cocaine users.
    Drug testing and analysis, 2017, Volume: 9, Issue:2

    Topics: Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Limit of Detection; Male; Solid Phase Extraction; Substance Abuse Detection

2017
Development of a method for the determination of cocaine, cocaethylene and norcocaine in human breast milk using liquid phase microextraction and gas chromatography-mass spectrometry.
    Forensic science international, 2016, Volume: 265

    Topics: Cocaine; Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Liquid Phase Microextraction; Milk, Human; Reproducibility of Results; Substance Abuse Detection

2016
Fluorescence Immunoassay for Cocaine Detection.
    Monoclonal antibodies in immunodiagnosis and immunotherapy, 2016, Volume: 35, Issue:2

    Topics: Antibodies, Monoclonal; Benzopyrans; Cocaine; Fluorescence; Humans; Immunoassay; Indoles; Limit of Detection

2016
A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood.
    Journal of pharmaceutical and biomedical analysis, 2017, Feb-05, Volume: 134

    Topics: Animals; Chromatography, Liquid; Cocaine; Humans; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2017
Determination of hydroxy metabolites of cocaine in hair samples for proof of consumption.
    Drug testing and analysis, 2018, Volume: 10, Issue:4

    Topics: Cocaine; Dopamine Uptake Inhibitors; Hair; Humans; Hydroxylation; Illicit Drugs; Limit of Detection; Substance Abuse Detection; Tandem Mass Spectrometry

2018
Illicit drugs and pharmaceuticals in swimming pool waters.
    The Science of the total environment, 2018, Sep-01, Volume: 635

    Topics: Amphetamines; Carbamazepine; Chromatography, High Pressure Liquid; Cocaine; Environmental Monitoring; Humans; Ibuprofen; Illicit Drugs; Ketoprofen; Pharmaceutical Preparations; Solid Phase Extraction; Swimming Pools; Water Pollutants, Chemical

2018
Discrimination between chewing of coca leaves or drinking of coca tea and smoking of "paco" (coca paste) by hair analysis. A preliminary study of possibilities and limitations.
    Forensic science international, 2019, Volume: 297

    Topics: Acetone; Adolescent; Adult; Biomarkers; Coca; Cocaine; Cocaine-Related Disorders; Female; Hair; Humans; Male; Mastication; Middle Aged; Plant Leaves; Pyrrolidines; Smoking; Substance Abuse Detection; Tea; Young Adult

2019
Simultaneous determination of cocaine, ecgonine methyl ester, benzoylecgonine, cocaethylene and norcocaine in dried blood spots by ultra-performance liquid chromatography coupled to tandem mass spectrometry.
    Forensic science international, 2019, Volume: 298

    Topics: Blood Stains; Chromatography, High Pressure Liquid; Cocaine; Hematocrit; Humans; Narcotics; Reproducibility of Results; Specimen Handling; Tandem Mass Spectrometry

2019
Simultaneous Determination of Cocaine and Metabolites in Human Plasma Using Solid Phase Micro-Extraction Fiber Tips C18 and UPLC-MS/MS.
    Journal of analytical toxicology, 2020, Jan-07, Volume: 44, Issue:1

    Topics: Amines; Chromatography, Liquid; Cocaine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Plasma; Solid Phase Microextraction; Substance Abuse Detection; Tandem Mass Spectrometry

2020
AEME production in cocaine positive hair after thermal hair treatment.
    Forensic science international, 2019, Volume: 302

    Topics: Biomarkers; Cocaine; Cocaine-Related Disorders; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Hair Preparations; Humans; In Vitro Techniques; Narcotics; Substance Abuse Detection

2019
In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice.
    Drug and alcohol dependence, 2019, 11-01, Volume: 204

    Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Lethal Dose 50; Locomotion; Male; Mice

2019
Ligand binding to a humanized anti-cocaine mAb measured by dye absorption spectroscopy.
    Biochemical and biophysical research communications, 2021, 01-08, Volume: 535

    Topics: Antibodies, Monoclonal; Cocaine; Coloring Agents; Fluorometry; Humans; Ligands; Spectrum Analysis

2021
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine.
    Organic & biomolecular chemistry, 2023, 05-03, Volume: 21, Issue:17

    Topics: Cocaine; Ethanol; Kinetics

2023