cocaine has been researched along with norbinaltorphimine in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Carroll, FI | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM | 1 |
| Heidbreder, C; LeFevour, A; Shippenberg, TS | 1 |
| Lin, CE; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Gerrits, MA; Kuzmin, AV; Van Ree, JM | 1 |
| Brodkin, ES; Carlezon, WA; Duman, RS; Hiroi, N; Lane-Ladd, SB; Nestler, EJ; Neve, RL; Olson, VG; Thome, J | 1 |
| Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Mello, NK; Negus, SS | 1 |
| Justice, JB; Sharpe, LG; Shippenberg, TS; Thompson, AC; Vaughan, RA; Zapata, A | 1 |
| Chavkin, C; Marton-Popovici, M; McLaughlin, JP | 1 |
| Butelman, ER; Ho, A; Kreek, MJ; Schlussman, SD; Zhang, Y | 1 |
| Negus, SS | 1 |
| Chavkin, C; Chavkin, TA; Li, S; McLaughlin, JP; Valdez, J | 1 |
| Chefer, VI; Shippenberg, TS | 1 |
| Kaminski, RM; Shippenberg, TS; Witkin, JM | 1 |
| Ding, Z; Phillips, AG; Powell, JA; Raffa, RB; Rawls, SM; Ross, G; Stagliano, GW | 1 |
| Antapasis, J; Bolaños Guzmán, CA; Herrera, CM; Poveromo, LB; Wiley, MD | 1 |
| Cashman, JR; Ghirmai, S; Koob, GF; Orio, L; Wee, S | 1 |
| Aita, M; Bruchas, MR; Chavkin, C; Giardino, WJ; Hnasko, TS; Land, BB; Messinger, D; Palmiter, RD; Schattauer, S | 1 |
| Chavkin, C; Li, S; Schindler, AG | 1 |
| Dong, Y; Mu, P; Neumann, PA; Panksepp, J; Schlüter, OM | 1 |
| Carlezon, WA; Chartoff, E; Pliakas, A; Potter, D; Rachlin, A; Sawyer, A | 1 |
| Chudnovskaya, D; Cowan, A; Huang, P; Liu-Chen, LY; Rasakham, K; Wang, YJ | 1 |
| Allen, CP; Leri, F; Zhou, Y | 1 |
| Chavkin, C; Chavkin, NW; Gustin, RM; Hagan, CE; Lemos, JC; Messinger, DI; Neumaier, JF; Schattauer, SS; Schindler, AG; Shankar, H; Smith, JS | 1 |
| Al-Hasani, R; Bruchas, MR; Foshage, AM; McCall, JG | 1 |
| Chavkin, C; Groblewski, PA; Phillips, PE; Willuhn, I; Zietz, C | 1 |
| Banks, ML; Cheng, K; Hutsell, BA; Negus, SS; Rice, KC | 1 |
| Banks, ML; Cheng, K; Moerke, MJ; Negus, SS; Rice, KC | 1 |
| George, O; Kallupi, M; Martin-Fardon, R; Matzeu, A; Schweitzer, P | 1 |
| Freeman, KB; Huskinson, SL; Naylor, JE; Prisinzano, TE; Townsend, EA; Zamarripa, CA | 1 |
2 review(s) available for cocaine and norbinaltorphimine
| Article | Year |
|---|---|
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Topics: Animals; Biogenic Monoamines; Biological Transport; Carrier Proteins; Cocaine; Fluorescent Dyes; Humans; Isoquinolines; Ligands; Morphinans; Narcotic Antagonists; Piperidines; Protein Binding; Radioisotopes; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders | 2003 |
Interactions between kappa opioid agonists and cocaine. Preclinical studies.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Discrimination Learning; Humans; Naloxone; Naltrexone; Receptors, Opioid, kappa; Self Administration | 2000 |
30 other study(ies) available for cocaine and norbinaltorphimine
| Article | Year |
|---|---|
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 1995 |
U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dopamine; Extracellular Space; Female; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1994 |
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 1996 |
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Kappa-opioid receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotics; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Self Administration; Time Factors | 1998 |
Regulation of cocaine reward by CREB.
Topics: Animals; Cocaine; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dynorphins; Gene Expression; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Point Mutation; Rats; Receptors, Opioid, kappa; Reward; RNA, Messenger; Simplexvirus | 1998 |
Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms.
Topics: Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Heroin; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Saimiri | 2000 |
Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine.
Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug Antagonism; Extracellular Space; Injections, Intraperitoneal; Injections, Subcutaneous; Iodine Radioisotopes; Linear Models; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Naltrexone; Nerve Tissue Proteins; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2000 |
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.
Topics: Analgesia; Animals; Behavior, Animal; Cocaine; Drug Synergism; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Threshold; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Reward; Spatial Behavior; Stress, Physiological; Swimming | 2003 |
Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Food; Male; Mice; Mice, Inbred C57BL; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Neostriatum; Pyrrolidines; Receptors, Opioid, kappa; Thiazines | 2004 |
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Eating; Macaca mulatta; Male; Naltrexone; Receptors, Opioid, kappa | 2004 |
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Enkephalins; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Social Behavior; Stress, Psychological | 2006 |
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines | 2006 |
Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.
Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Pyrrolidines; Receptors, Opioid, kappa; Seizures | 2007 |
The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.
Topics: Amphetamine; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Interactions; Morpholines; Naltrexone; Naphthalenes; Narcotic Antagonists; Planarians; Substance Withdrawal Syndrome; Time Factors | 2008 |
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Food Preferences; Male; Methylphenidate; Motor Activity; Naltrexone; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine.
Topics: Animals; CHO Cells; Cocaine; Conditioning, Operant; Cricetinae; Cricetulus; Drug Interactions; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration | 2009 |
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Cocaine; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Physiological; Ventral Tegmental Area | 2009 |
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Exploratory Behavior; Male; Mental Recall; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reward; Stress, Psychological; Swimming | 2010 |
Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons.
Topics: Animals; Cocaine; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Male; Naltrexone; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Synaptic Transmission | 2011 |
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Routes; Immobility Response, Tonic; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Swimming; Time Factors | 2012 |
Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Mice; Motor Activity; Movement; Naltrexone; Narcotic Antagonists; Posture; Rats; Receptors, Opioid, kappa; Sex Characteristics | 2011 |
Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptors.
Topics: Animals; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Food Deprivation; Male; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Topics: Animals; Avoidance Learning; Brain; Cocaine; Corpus Striatum; Dopamine; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microinjections; Naltrexone; Narcotic Antagonists; Nicotine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Raphe Nuclei; Receptors, Opioid, kappa; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Synaptosomes | 2012 |
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naltrexone; Propanolamines; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid, kappa | 2013 |
Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Economics, Behavioral; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred WKY; Rats, Wistar; Self Administration; Stress, Psychological; Swimming | 2015 |
Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Drug-Seeking Behavior; Food Preferences; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Self Administration | 2016 |
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
Topics: Administration, Intravenous; Animals; Choice Behavior; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Food; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2017 |
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Extinction, Psychological; Male; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Reward; Self Administration | 2018 |
Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Cocaine; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphinans; Naltrexone; Narcotic Antagonists; Oxycodone; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration; Spiro Compounds | 2020 |