cocaine has been researched along with nifedipine in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.89) | 18.7374 |
| 1990's | 12 (25.53) | 18.2507 |
| 2000's | 18 (38.30) | 29.6817 |
| 2010's | 9 (19.15) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Sen, S; Sinha, N | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Keserü, GM | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Masukawa, Y; Misawa, M; Shiozaki, Y; Suzuki, T | 1 |
| Jaffe, JH; Kumor, KM; Muntaner, C; Nagoshi, C | 1 |
| Alker, KJ; Eisenhauer, AC; Hale, SL; Kloner, RA; Rezkalla, SH | 1 |
| Rogério, R; Takahashi, RN | 1 |
| Albertson, TE; Derlet, RW | 1 |
| Eikenburg, DC; Jandhyala, BS; Lokhandwala, MF; Peter, EJ; Steenberg, ML | 1 |
| Andersson, KE; Högestätt, ED; Skärby, T | 1 |
| Maillet, M; Nahas, G; Trouve, R | 1 |
| Demus, JR; Nahas, G; Trouvé, R; von Sitbon, M | 1 |
| MacDonald, A; McGrath, JC | 1 |
| Brewster, PS; Fraker, TD; Temesy-Armos, PN; Wilkerson, RD | 1 |
| Branch, CA; Knuepfer, MM | 1 |
| Carpentier, RG; Coleman, BR; Patel, DJ | 3 |
| Albertson, TE; Derlet, RW; Tseng, CC | 1 |
| Biała, G; Langwiński, R | 1 |
| Aldasoro, M; Lluch, S; Martínez, MC; Medina, P; Noguera, I; Segarra, G; Vila, JM | 1 |
| He, J; Xiao, Y; Zhang, L | 1 |
| Ansah, TA; Kopsombut, P; Shockley, DC; Wade, LH | 1 |
| Cleary, L; Docherty, JR; Vandeputte, C | 2 |
| Anderson, K; Dudeja, PK; Ou, DW; Shen, HM | 1 |
| Hu, XT; Nasif, FJ; White, FJ | 1 |
| Cao, N; Haynes, JM; Ventura, S | 1 |
| Broadley, KJ; Penson, PE | 1 |
| Mitcheva, M; Vitcheva, V | 1 |
| Kurokawa, K; Ohkuma, S; Shibasaki, M | 1 |
| Giordano, TP; Kosofsky, BE; Rajadhyaksha, AM; Satpute, SS; Sinnegger-Brauns, MJ; Striessnig, J; Tropea, TF | 1 |
| Wu, D; Yee, LM | 1 |
| Karova, D; Mitcheva, M; Simeonova, R; Vitcheva, V | 1 |
| Kurokawa, K; Mizuno, K; Ohkuma, S; Shibasaki, M | 1 |
| Docherty, JR; Killian, LM | 1 |
| Allen, CP; Du, C; Koob, GF; Pan, Y; Park, K; Volkow, ND; You, J | 1 |
1 trial(s) available for cocaine and nifedipine
| Article | Year |
|---|---|
Effects of nifedipine pretreatment on subjective and cardiovascular responses to intravenous cocaine in humans.
Topics: Adult; Affect; Anxiety; Blood Pressure; Cocaine; Confusion; Double-Blind Method; Electrocardiography; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Nifedipine; Psychiatric Status Rating Scales; Random Allocation | 1991 |
46 other study(ies) available for cocaine and nifedipine
| Article | Year |
|---|---|
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Effects of calcium antagonists on the cocaine- and methamphetamine-induced conditioned place preference.
Topics: Animals; Calcium Channel Blockers; Cocaine; Conditioning, Psychological; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Methamphetamine; Nifedipine; Rats; Rats, Inbred Strains | 1992 |
Nifedipine protects the heart from the acute deleterious effects of cocaine if administered before but not after cocaine.
Topics: Animals; Cocaine; Coronary Circulation; Coronary Disease; Depression, Chemical; Dogs; Heart; Hemodynamics; Nifedipine; Premedication; Ventricular Function, Left | 1991 |
Some calcium channel antagonists have no effect on the open-field behavior of rats nor do they interact with cocaine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Diltiazem; Drug Interactions; Male; Motor Activity; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Potentiation of cocaine toxicity with calcium channel blockers.
Topics: Animals; Cocaine; Diltiazem; Drug Synergism; Injections, Intraperitoneal; Male; Nifedipine; Rats; Rats, Inbred Strains; Seizures; Verapamil | 1989 |
Influence of felodipine and verapamil on the sympathetic transmitter release and on the pre- and post-junctional effects of exogenous noradrenaline in the perfused rat kidney.
Topics: Animals; Antihypertensive Agents; Cocaine; Electric Stimulation; Felodipine; In Vitro Techniques; Kidney; Male; Neuromuscular Junction; Neurotransmitter Agents; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Verapamil | 1985 |
Influence of extracellular calcium and nifedipine on alpha 1- and alpha 2-adrenoceptor-mediated contractile responses in isolated rat and cat cerebral and mesenteric arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cats; Cerebral Arteries; Cocaine; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Sodium; Yohimbine | 1985 |
[Prevention of the cardiotoxicity of cocaine using a calcium blocker].
Topics: Animals; Cardiomyopathies; Cocaine; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains | 1985 |
A calcium-channel blocker as antidote to the cardiac effects of cocaine intoxication.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Cocaine; Dogs; Nifedipine; Nitrendipine; Rats | 1985 |
Post-natal development of functional neurotransmission in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Neuroeffector Junction; Nifedipine; Norepinephrine; Oxymetazoline; Rats; Receptors, Adrenergic, alpha; Synaptic Transmission; Vas Deferens; Xylazine; Yohimbine | 1984 |
Interaction of propranolol, verapamil, and nifedipine on the myocardial depressant effect of cocaine.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cocaine; Dogs; Drug Interactions; Echocardiography; Electrocardiography; Female; Heart Rate; Male; Nifedipine; Propranolol; Stroke Volume; Ventricular Function, Left; Verapamil | 1995 |
Calcium channel antagonists reduce the cocaine-induced decrease in cardiac output in a subset of rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cocaine; Heart Rate; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Stroke Volume; Vascular Resistance; Verapamil | 1993 |
Mechanism of the negative inotropic action of cocaine in rat papillary muscle.
Topics: Animals; Carrier Proteins; Cocaine; Depression, Chemical; In Vitro Techniques; Male; Myocardial Contraction; Nifedipine; Papillary Muscles; Propranolol; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger | 1993 |
Acute cocaine toxicity: the effect of agents in non-seizure-induced death.
Topics: Animals; Anticonvulsants; Cocaine; Diazepam; Electrodes, Implanted; Electroencephalography; Male; Nifedipine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Seizures | 1993 |
Mechanism of the positive inotropic action of cocaine in the guinea pig atrium.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Calcium Channel Blockers; Cocaine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Male; Myocardial Contraction; Nifedipine; Organ Culture Techniques; Stimulation, Chemical | 1996 |
Effects of calcium channel antagonists on the reinforcing properties of morphine, ethanol and cocaine as measured by place conditioning.
Topics: Animals; Calcium; Calcium Channel Blockers; Cocaine; Conditioning, Psychological; Ethanol; Male; Morphine; Nifedipine; Rats; Rats, Wistar; Reward; Substance-Related Disorders | 1996 |
Potentiation by vasopressin of adrenergic vasoconstriction in the rat isolated mesenteric artery.
Topics: Animals; Arginine Vasopressin; Calcium Channel Blockers; Cocaine; Electric Stimulation; Hormone Antagonists; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Receptors, Adrenergic; Vasoconstriction; Vasopressins; Vasotocin | 1997 |
Adrenergic-mediated effects of cocaine on the myocardial force-frequency relationship.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cocaine; Electrodes, Implanted; Guinea Pigs; Heart Rate; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Nifedipine; Phentolamine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sarcolemma; Sympathetic Nervous System; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Cocaine induces apoptosis in human coronary artery endothelial cells.
Topics: Apoptosis; Caspase Inhibitors; Cells, Cultured; Cocaine; Coronary Vessels; Cyclosporine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Humans; Naloxone; Narcotic Antagonists; Nifedipine; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Nifedipine potentiates the toxic effects of cocaine in mice.
Topics: Animals; Calcium Channel Blockers; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Electrolytes; Injections, Intraperitoneal; Lethal Dose 50; Mice; Mice, Inbred ICR; Nifedipine | 2002 |
Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cocaine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Nifedipine; Radioligand Assay; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Vas Deferens; Xylazine | 2002 |
Investigation of postjunctional alpha1- and alpha2-adrenoceptor subtypes in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cocaine; Electric Stimulation; Imidazoles; Indoles; Isoindoles; Isometric Contraction; Male; Mice; Mice, Knockout; Nifedipine; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic; Suramin; Thymine; Vas Deferens; Yohimbine | 2003 |
Cocaine increases intracellular calcium in the interferon-gamma-primed macrophages but not in the LPS-primed-macrophages.
Topics: Animals; Antigen-Presenting Cells; Calcium; Calcium Channel Blockers; Cocaine; Fluorescent Dyes; Fura-2; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nifedipine | 2002 |
Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons.
Topics: Animals; Cadmium Chloride; Calcium; Calcium Channel Blockers; Calcium Channels; Cesium; Chlorides; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Potassium Channel Blockers; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetraethylammonium; Tetrodotoxin; Time Factors | 2005 |
Saw palmetto is an indirectly acting sympathomimetic in the rat-isolated prostate gland.
Topics: Amphetamine; Animals; Cocaine; Desipramine; Electric Stimulation; Guanethidine; Male; Nifedipine; Phentolamine; Plant Extracts; Prazosin; Prostate; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Serenoa; Sympathomimetics; Tyramine; Urinary Bladder; Vas Deferens | 2006 |
Effects of hypoxia on the vasodilator activity of nifedipine and evidence of secondary pharmacological properties.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cocaine; Dose-Response Relationship, Drug; Hypoxia; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Phenylephrine; Propranolol; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Changes in liver and brain cytochrome p450 after multiple cocaine administration, alone and in combination with nifedipine.
Topics: Animals; Brain; Calcium Channel Blockers; Cocaine; Cytochrome P-450 Enzyme System; Drug Interactions; Liver; Male; Microsomes; Nifedipine; Rats; Rats, Wistar | 2007 |
Upregulation of L-type Ca(v)1 channels in the development of psychological dependence.
Topics: Animals; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cocaine; Disease Models, Animal; Frontal Lobe; Limbic System; Male; Methamphetamine; Mice; Morphine; Nifedipine; Substance-Related Disorders; Up-Regulation | 2010 |
Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity.
Topics: Aminoacetonitrile; Amphetamine; Animals; Benzazepines; Calcium Channels, L-Type; Central Nervous System Stimulants; Cocaine; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Male; Mice; Mice, Knockout; Motor Activity; Nifedipine; Nucleus Accumbens; Signal Transduction | 2010 |
False-positive amphetamine toxicology screen results in three pregnant women using labetalol.
Topics: Adult; Amphetamine; Antihypertensive Agents; Cesarean Section; Chronic Disease; Cocaine; Cross Reactions; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension, Pregnancy-Induced; Immunoassay; Infant, Newborn; Labetalol; Nifedipine; Pregnancy; Pregnancy Outcome; Pulmonary Edema; Stillbirth; Substance Abuse Detection | 2011 |
Nifedipine lowers cocaine-induced brain and liver enzyme activity and cocaine urinary excretion in rats.
Topics: Aniline Hydroxylase; Animals; Brain; Cocaine; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Glutathione; Liver; Male; Nifedipine; Nitric Oxide Synthase Type I; Rats; Rats, Wistar | 2011 |
Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Cerebellum; Cocaine; Conditioning, Operant; Dantrolene; Dopamine Uptake Inhibitors; Frontal Lobe; Male; Mice; Nifedipine; Prosencephalon; Receptors, Dopamine D1; Ryanodine Receptor Calcium Release Channel | 2011 |
Cardiovascular stimulant actions of bupropion in comparison to cocaine in the rat.
Topics: Animals; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Cocaine; Desipramine; Electric Stimulation; Heart Ventricles; Hydroxamic Acids; In Vitro Techniques; Male; Modafinil; Myocardial Contraction; Nifedipine; Rats, Wistar; Vas Deferens | 2014 |
Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Ischemia; Male; Mice; Nifedipine; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration | 2020 |