cocaine has been researched along with metyrapone in 15 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (33.33) | 18.2507 |
2000's | 3 (20.00) | 29.6817 |
2010's | 7 (46.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Le Moal, M; Marinelli, M; Piazza, PV; Rougé-Pont, F; Simon, H | 1 |
Holsapple, MP; Jeong, TC; Jordan, SD; Matulka, RA; Park, SS; Stanulis, ED | 1 |
Goeders, NE; Guerin, GF | 1 |
Le Moal, M; Marinelli, M; Piazza, PV | 1 |
De Jesus-Oliveira, C; Le Moal, M; Marinelli, M; Piazza, PV; Rougé-Pont, F | 1 |
Elkashef, A; Harrer, JM; Kropp, F; Mojsiak, J; Moore, E; Singal, B; Somoza, E; Ussery, T; Winhusen, T | 1 |
Hunter, RG; Kuhar, MJ; Rogge, G; Vicentic, A | 1 |
Budziszewska, B; Chocyk, A; Grzegorzewska, M; Hess, G; Maćkowiak, M; Wedzony, K | 1 |
Casso, S; DeMuth, G; Fox, BS; Goeders, NE; Hefti, F; Kablinger, AS; Lindner, MA; McCarthy, BG; McNair, LA | 1 |
Goeders, NE; Guerin, GF; Schmoutz, CD | 2 |
Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD | 1 |
Breaux, KN; Goeders, NE; Keller, CM | 1 |
Goeders, NE; Keller, CM | 1 |
2 trial(s) available for cocaine and metyrapone
Article | Year |
---|---|
Metyrapone and cocaine: a double-blind, placebo-controlled drug interaction study.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Blood Pressure; Cocaine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Heart Rate; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged | 2005 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; GABA Agonists; Humans; Louisiana; Male; Metyrapone; Middle Aged; Oxazepam; Patient Compliance; Patient Dropouts; Pilot Projects; Secondary Prevention; Steroid 11-beta-Hydroxylase; Substance Withdrawal Syndrome | 2012 |
13 other study(ies) available for cocaine and metyrapone
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion.
Topics: Animals; Cocaine; Corticosterone; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Food Deprivation; Male; Metyrapone; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stress, Physiological | 1995 |
Immunosuppression induced by acute exposure to cocaine is dependent on metabolism by cytochrome P-450.
Topics: Animals; Blotting, Western; Cocaine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Immunosuppression Therapy; Metyrapone; Mice; Mice, Inbred C57BL | 1996 |
Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats.
Topics: Adrenalectomy; Animals; Cocaine; Corticosterone; Injections, Intravenous; Male; Metyrapone; Rats; Rats, Wistar; Self Administration | 1996 |
Acute pharmacological blockade of corticosterone secretion reverses food restriction-induced sensitization of the locomotor response to cocaine.
Topics: Animals; Cocaine; Corticosterone; Food Deprivation; Male; Metyrapone; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley | 1996 |
Acute blockade of corticosterone secretion decreases the psychomotor stimulant effects of cocaine.
Topics: Animals; Brain; Cocaine; Corticosterone; Locomotion; Male; Metyrapone; Rats; Rats, Sprague-Dawley | 1997 |
The effects of cocaine on CART expression in the rat nucleus accumbens: a possible role for corticosterone.
Topics: Animals; Antimetabolites; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Gene Expression; In Situ Hybridization; Male; Metyrapone; Nerve Tissue Proteins; Nucleus Accumbens; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2005 |
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Corticosterone; Dentate Gyrus; Dopamine Uptake Inhibitors; Down-Regulation; Ki-67 Antigen; Long-Term Potentiation; Male; Memory; Memory Disorders; Metyrapone; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Cell Adhesion Molecule L1; Neurons; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sialic Acids; Spironolactone | 2008 |
The extra-adrenal effects of metyrapone and oxazepam on ongoing cocaine self-administration.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Anti-Anxiety Agents; Cocaine; Conditioning, Operant; Corticosterone; Drug-Seeking Behavior; Extinction, Psychological; Male; Metyrapone; Oxazepam; Rats; Rats, Wistar; Self Administration; Stress, Physiological | 2014 |
Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction.
Topics: 5-alpha Reductase Inhibitors; Animals; Bicuculline; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Enzyme Inhibitors; Finasteride; Food; GABA-A Receptor Antagonists; Male; Metyrapone; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration | 2014 |
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; GABA Modulators; Male; Metyrapone; Motivation; Oxazepam; Pregnanolone; Rats, Wistar; Self Administration | 2015 |
Effects of the combination of metyrapone and oxazepam on cocaine-induced increases in corticosterone in the medial prefrontal cortex and nucleus accumbens.
Topics: Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Enzyme Inhibitors; GABA Modulators; Male; Metyrapone; Nucleus Accumbens; Oxazepam; Prefrontal Cortex; Rats; Rats, Wistar | 2017 |
Lack of effect of the combination of metyrapone and oxazepam on brain dopamine.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corticosterone; Dopamine; Dopamine Uptake Inhibitors; Male; Metyrapone; Nucleus Accumbens; Oxazepam; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration | 2019 |