cocaine and metyrapone

cocaine has been researched along with metyrapone in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (33.33)	18.2507
2000's	3 (20.00)	29.6817
2010's	7 (46.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Le Moal, M; Marinelli, M; Piazza, PV; Rougé-Pont, F; Simon, H	1
Holsapple, MP; Jeong, TC; Jordan, SD; Matulka, RA; Park, SS; Stanulis, ED	1
Goeders, NE; Guerin, GF	1
Le Moal, M; Marinelli, M; Piazza, PV	1
De Jesus-Oliveira, C; Le Moal, M; Marinelli, M; Piazza, PV; Rougé-Pont, F	1
Elkashef, A; Harrer, JM; Kropp, F; Mojsiak, J; Moore, E; Singal, B; Somoza, E; Ussery, T; Winhusen, T	1
Hunter, RG; Kuhar, MJ; Rogge, G; Vicentic, A	1
Budziszewska, B; Chocyk, A; Grzegorzewska, M; Hess, G; Maćkowiak, M; Wedzony, K	1
Casso, S; DeMuth, G; Fox, BS; Goeders, NE; Hefti, F; Kablinger, AS; Lindner, MA; McCarthy, BG; McNair, LA	1
Goeders, NE; Guerin, GF; Schmoutz, CD	2
Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD	1
Breaux, KN; Goeders, NE; Keller, CM	1
Goeders, NE; Keller, CM	1

Trials

2 trial(s) available for cocaine and metyrapone

Article	Year
Metyrapone and cocaine: a double-blind, placebo-controlled drug interaction study. Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:4 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Blood Pressure; Cocaine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Heart Rate; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged	2005
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study. Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:7 Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; GABA Agonists; Humans; Louisiana; Male; Metyrapone; Middle Aged; Oxazepam; Patient Compliance; Patient Dropouts; Pilot Projects; Secondary Prevention; Steroid 11-beta-Hydroxylase; Substance Withdrawal Syndrome	2012

Article

Year

Metyrapone and cocaine: a double-blind, placebo-controlled drug interaction study.

Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:4

Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Blood Pressure; Cocaine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Heart Rate; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged

2005

Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.

Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:7

Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; GABA Agonists; Humans; Louisiana; Male; Metyrapone; Middle Aged; Oxazepam; Patient Compliance; Patient Dropouts; Pilot Projects; Secondary Prevention; Steroid 11-beta-Hydroxylase; Substance Withdrawal Syndrome

2012

Other Studies

13 other study(ies) available for cocaine and metyrapone

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:11 Topics: Animals; Cocaine; Corticosterone; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Food Deprivation; Male; Metyrapone; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stress, Physiological	1995
Immunosuppression induced by acute exposure to cocaine is dependent on metabolism by cytochrome P-450. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:3 Topics: Animals; Blotting, Western; Cocaine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Immunosuppression Therapy; Metyrapone; Mice; Mice, Inbred C57BL	1996
Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats. Brain research, 1996, May-25, Volume: 722, Issue:1-2 Topics: Adrenalectomy; Animals; Cocaine; Corticosterone; Injections, Intravenous; Male; Metyrapone; Rats; Rats, Wistar; Self Administration	1996
Acute pharmacological blockade of corticosterone secretion reverses food restriction-induced sensitization of the locomotor response to cocaine. Brain research, 1996, Jun-17, Volume: 724, Issue:2 Topics: Animals; Cocaine; Corticosterone; Food Deprivation; Male; Metyrapone; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley	1996
Acute blockade of corticosterone secretion decreases the psychomotor stimulant effects of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1997, Volume: 16, Issue:2 Topics: Animals; Brain; Cocaine; Corticosterone; Locomotion; Male; Metyrapone; Rats; Rats, Sprague-Dawley	1997
The effects of cocaine on CART expression in the rat nucleus accumbens: a possible role for corticosterone. European journal of pharmacology, 2005, Jul-04, Volume: 517, Issue:1-2 Topics: Animals; Antimetabolites; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Gene Expression; In Situ Hybridization; Male; Metyrapone; Nerve Tissue Proteins; Nucleus Accumbens; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger	2005
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus. The European journal of neuroscience, 2008, Volume: 27, Issue:11 Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Corticosterone; Dentate Gyrus; Dopamine Uptake Inhibitors; Down-Regulation; Ki-67 Antigen; Long-Term Potentiation; Male; Memory; Memory Disorders; Metyrapone; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Cell Adhesion Molecule L1; Neurons; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Sialic Acids; Spironolactone	2008
The extra-adrenal effects of metyrapone and oxazepam on ongoing cocaine self-administration. Brain research, 2014, Aug-05, Volume: 1575 Topics: Adrenal Medulla; Adrenalectomy; Animals; Anti-Anxiety Agents; Cocaine; Conditioning, Operant; Corticosterone; Drug-Seeking Behavior; Extinction, Psychological; Male; Metyrapone; Oxazepam; Rats; Rats, Wistar; Self Administration; Stress, Physiological	2014
Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction. Behavioural brain research, 2014, Sep-01, Volume: 271 Topics: 5-alpha Reductase Inhibitors; Animals; Bicuculline; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Enzyme Inhibitors; Finasteride; Food; GABA-A Receptor Antagonists; Male; Metyrapone; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration	2014
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats. Behavioural brain research, 2015, Sep-15, Volume: 291 Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; GABA Modulators; Male; Metyrapone; Motivation; Oxazepam; Pregnanolone; Rats, Wistar; Self Administration	2015
Effects of the combination of metyrapone and oxazepam on cocaine-induced increases in corticosterone in the medial prefrontal cortex and nucleus accumbens. Psychoneuroendocrinology, 2017, Volume: 77 Topics: Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Enzyme Inhibitors; GABA Modulators; Male; Metyrapone; Nucleus Accumbens; Oxazepam; Prefrontal Cortex; Rats; Rats, Wistar	2017
Lack of effect of the combination of metyrapone and oxazepam on brain dopamine. Brain research, 2019, 12-01, Volume: 1724 Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corticosterone; Dopamine; Dopamine Uptake Inhibitors; Male; Metyrapone; Nucleus Accumbens; Oxazepam; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration	2019