cocaine has been researched along with methylphenidate in 249 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (28.11) | 18.7374 |
| 1990's | 34 (13.65) | 18.2507 |
| 2000's | 67 (26.91) | 29.6817 |
| 2010's | 66 (26.51) | 24.3611 |
| 2020's | 12 (4.82) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, DE; L'Italien, YJ; Marriott, JG; Nordin, IC; Poschel, PH; Zweisler, L | 1 |
| Dakin, LA; Deschamps, JR; Froimowitz, M; Gu, Y; Janowsky, A; Kelley, CJ; Nagafuji, PM; Parrish, D | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Aggarwal, S; Foster, JD; Huang, Y; Lapinsky, DJ; Lever, JR; Surratt, CK; Vaughan, RA | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Shore, PA | 1 |
| Ho, BT; Silverman, PB | 1 |
| Jones, BE; Risner, ME | 1 |
| Tessel, RE; Tyler, TD | 1 |
| Sansone, M | 1 |
| Arnt, J; Christensen, AV; Scheel-Krüger, J | 1 |
| Rech, RH; Rickert, DE; Vomachka, MK | 1 |
| Ho, BT; Taylor, D | 1 |
| Brady, JV; Griffiths, RR | 1 |
| Heffner, TG; Stricker, EM; Zigmond, MJ | 2 |
| Moore, KE; Ravitz, AJ | 1 |
| Braestrup, C; Scheel-Krüger, J | 1 |
| Grant, I; Mohns, L | 1 |
| Johanson, CE; Schuster, CR | 1 |
| Brady, JV; Dolan-Gutcher, K; Findley, JD; Griffiths, RR; Robinson, WW | 1 |
| Culbertson, CT; Deutsch, HM; Schweri, MM; Zalkow, LH | 1 |
| Dackis, CA; Gold, MS | 1 |
| Asami, T; Ida, I; Kuribara, H; Machiyama, Y; Tadokoro, S | 1 |
| Cox, BM; Izenwasser, S; Werling, LL | 1 |
| Bergman, J; Johnson, SE; Madras, BK; Spealman, RD | 1 |
| Andersen, PH | 1 |
| Colpaert, FC; Kamenka, JM; Koek, W; Woods, JH | 1 |
| Atkinson, J; Goudie, AJ; West, CR | 1 |
| Gawin, FH | 1 |
| Goldschlager, N; Lam, D | 1 |
| Lee, EH; Mandell, AJ | 1 |
| Gawin, F; Kleber, H; Riordan, C | 1 |
| Handley, SL; Sayers, AC | 1 |
| Lipton, MA | 1 |
| Georgi, H; Gey, KF | 1 |
| Angrist, B; Gershon, S | 1 |
| Dashputra, PG; Jayaswal, CL; Rajapurkar, MV; Sharma, ML | 1 |
| Gokhale, SD; Gulati, OD; Udwadia, BP | 1 |
| Gillis, CN; Schneider, FH | 1 |
| Fog, R | 2 |
| Chaplin, E; Eckhardt, SB; Hite, G; Maxwell, RE; Soares, JR | 1 |
| Carr, LA; Moore, KE | 1 |
| Hitomi, M; Schuster, CR; Wilson, MC | 1 |
| Schuster, CR; Wilson, MC | 1 |
| Brody, TM; Commarato, MA; McNeill, JH | 1 |
| Gershon, S; Wallach, MB | 1 |
| Del Basso, P; Longo, VG; Ziegler, H | 1 |
| Bejerot, N | 1 |
| Lorez, HP | 1 |
| Schroeder, LA; Tang, AH | 1 |
| Buckner, CK; Malspeis, L; Patil, PN; Tye, A | 1 |
| Doctor, RB; Jindal, MN; Kelkar, VV | 1 |
| Eckhardt, SB; Maxwell, RA; Wastila, WB | 1 |
| Bartholomew, AA; Reynolds, WS | 1 |
| Gawin, FH; Kleber, HD | 2 |
| Resnick, EB; Resnick, RB | 1 |
| Gawin, F; Khantzian, EJ; Kleber, HD; Riordan, CE | 1 |
| Chapin, DS; Moore, KE; Nielsen, JA | 1 |
| Crowley, TJ | 1 |
| Barrett, RJ; Leith, NJ | 1 |
| Emmett-Oglesby, MW; Lal, H; Wurst, M | 1 |
| Khantzian, EJ | 1 |
| Berger, PA | 1 |
| Ding, YS; Fowler, JS; Gatley, SJ; Logan, J; MacGregor, RR; Volkow, ND; Wang, GJ; Wolf, AP | 1 |
| Chen, R; Ding, YS; Fowler, JS; Gatley, SJ; Sugano, Y; Volkow, ND | 1 |
| Bonnet, JJ; Costentin, J; Héron, C | 1 |
| Ashby, C; Dewey, S; Ding, YS; Fowler, JS; Gatley, JS; Hitzemann, R; Liebermann, J; Logan, J; Volkow, ND; Wang, GJ | 1 |
| Alexoff, DA; Chen, R; Dewey, SL; Ding, YS; Fowler, JS; Gatley, SJ; Pan, D | 1 |
| Alexoff, DL; Fowler, JS; Gatley, SJ; King, P; Schlyer, DJ; Shea, C; Wolf, AP | 1 |
| O'Neill, WM | 1 |
| Cody, V; Froimowitz, M; Patrick, KS | 1 |
| Deutsch, HM; Gruszecka-Kowalik, E; Schweri, MM; Shi, Q | 1 |
| Fowler, JS; Hitzemann, R; Volkow, ND; Wang, GJ | 1 |
| Ding, YS; Fowler, JS; Volkow, ND; Wang, GJ | 1 |
| Ding, YS; Gatley, SJ; Gifford, AN; Logan, J; Volkow, ND; Wang, GJ | 1 |
| Barbato, M; Cooper, T; Elangovan, N; Winsberg, B | 1 |
| Chen, AD; Dewey, SL; Fowler, JS; Gatley, SJ; Hitzemann, R; Logan, J; Pappas, N; Volkow, ND; Wang, GJ | 1 |
| Ding, YS; Fowler, JS; Gatley, SJ; Volkow, ND; Wang, GJ | 1 |
| Ding, YS; Fowler, JS; Gatley, SJ; King, P; Logan, J; Pappas, N; Volkow, ND; Wang, GJ | 1 |
| Lesch, KP; Li, XF; Murphy, DL; Revay, R; Sora, I; Takahashi, N; Uhl, GR; Wichems, C; Zeng, Z | 1 |
| Evans, SM; Kleber, HD; Levin, FR; McDowell, DM | 1 |
| de Costa, BR; Rice, KC; Schweri, MM | 1 |
| Ding, YS; Fowler, JS; Gatley, SJ; Hitzemann, R; Logan, J; Pappas, N; Volkow, ND; Wang, GJ | 1 |
| Dewey, SL; Ding, YS; Fowler, JS; Gatley, SJ; Gifford, AN; Hitzemann, R; Logan, J; Pappas, NR; Volkow, ND; Wang, GJ | 1 |
| Dewey, SL; Ding, YS; Fowler, JS; Franceschi, D; Gatley, SJ; Gifford, A; King, P; Logan, J; Morgan, A; Pappas, N; Volkow, ND; Wang, GJ | 1 |
| Deutsch, H; Schenk, JO; Schweri, MM; Wayment, HK | 1 |
| McDougall, SA; Nazarian, A; Rodarte-Freeman, AL | 1 |
| Abumrad, NN; Ding, YS; Fischman, M; Foltin, R; Fowler, JS; Gatley, SJ; Gifford, A; Hitzemann, R; Logan, J; Pappas, N; Volkow, ND; Wang, GJ; Wong, C | 1 |
| Cadet, JL; Coy, AE; French, D; Izenwasser, S; Ladenheim, B; Loeloff, RJ | 1 |
| Dewey, S; Ding, YS; Fischman, MW; Foltin, R; Fowler, JS; Hitzemann, R; Volkow, ND; Wang, GJ | 1 |
| Dewey, SL; Ding, YS; Fowler, JS; Gatley, SJ; Gifford, AN; Logan, J; Volkow, ND | 1 |
| Kuczenski, R; Segal, DS | 1 |
| Baldessarini, RJ; Fisser, R; Kula, NS; Neumeyer, JL; Tarazi, FI; Trometer, J; Wang, S | 1 |
| Dewey, SL; Franceschi, M; Gerasimov, MR; Rice, O; Schiffer, WK; Volkow, ND | 1 |
| Fleckenstein, AE; Hanson, GR; Riddle, EL; Sandoval, V; Ugarte, YV | 1 |
| Deutsch, HM; Liu, Z; Schweri, MM; Shi, Q; Ye, X | 1 |
| Baker, RW; Rush, CR | 1 |
| Baker, LK; Brandon, CL; Marinelli, M; White, FJ | 1 |
| Andersen, SL; Arvanitogiannis, A; Carlezon, WA; LeBlanc, C; Pliakas, AM | 1 |
| Itzhak, Y; Martin, JL | 1 |
| Ding, YS; Fowler, JS; Franceschi, D; Gatley, SJ; Gifford, A; Logan, J; Maynard, L; Swanson, JM; Volkow, ND; Wang, GJ; Zhu, W | 1 |
| Kankaanpää, A; Meririnne, E; Seppälä, T | 1 |
| Baldessarini, RJ; Davids, E; Tarazi, FI; Zhang, K | 1 |
| Madras, BK; Miller, GM; Norton, C; Yatin, SM | 1 |
| Chen, JC; Hwang, JJ; Liao, MH; Lin, KJ; Pan, WH; Ting, G; Wey, SP; Yen, TC | 1 |
| Izenwasser, S; Schenk, S | 1 |
| Bondareva, TS; Glennon, RA; Young, R | 1 |
| Schenk, JO | 1 |
| Fleckenstein, AE; Hanson, GR; Rau, KS; Riddle, EL; Topham, MK | 1 |
| Browman, KE; Curzon, P; Decker, MW; Fox, GB; Hancock, AA; Komater, VA | 1 |
| Achat-Mendes, C; Anderson, KL; Itzhak, Y | 1 |
| Bohn, AM; Khodaee, M; Schwenk, TL | 1 |
| COOMBS, H; MAXWELL, RA; PLUMMER, AJ; POVALSKI, H; SCHNEIDER, F | 1 |
| DAY, MD; RAND, MJ | 1 |
| CHITTAL, SM; SHETH, UK | 1 |
| SCHMITT, H | 2 |
| DIPALMA, JR; ROSENTHALE, ME | 1 |
| BOFF, E; SCHECKEL, CL | 1 |
| LUDDEN, CT; PORTER, CC; STAVORSKI, JM; STONE, CA; TOTARO, JA | 1 |
| JACOBSON, J; URSILLO, RC | 1 |
| HAHN, RA; LAPIDUS, JB; NELSON, JW; TYE, A | 1 |
| GOKHALE, SD; GULATI, OD; JOSHI, NY | 1 |
| DANIEL, AI; MAXWELL, RA; SHEPPARD, H; ZIMMERMAN, JH | 1 |
| Brandon, CL; Steiner, H | 1 |
| Kollins, SH | 1 |
| Swanson, JM; Volkow, ND | 1 |
| Carboni, E; Di Chiara, G; Silvagni, A; Valentini, V | 1 |
| Andersen, SL; Carlezon, WA; Mague, SD | 2 |
| Fukui, R; Greengard, P; Higashi, H; Matsuishi, T; Nairn, AC; Nishi, A; Svenningsson, P | 1 |
| Bergman, J; Czoty, PW; Makriyannis, A | 1 |
| Carter, P; Ding, YS; Fowler, JS; Garza, V; Gatley, SJ; King, P; Park, DJ; Pyatt, B; Shea, C; Taintor, NB; Thanos, PK; Volkow, ND; Warner, D; Xu, Y | 1 |
| Bergman, J; Gasior, M; Kallman, MJ; Paronis, CA | 1 |
| Boutrel, B; Koob, GF | 1 |
| Egestad, B; Kehr, J; Weikop, P | 1 |
| Bernardi, G; Federici, M; Geracitano, R; Mercuri, NB | 1 |
| Dow-Edwards, DL; Torres-Reverón, A | 1 |
| Dowd, JJ; Middaugh, LD; Oatis, JE; Patrick, KS; VanWert, AL; Williard, RL | 1 |
| Bondi, CD; Kozikowski, AP; Kulkarni, SS; Newman, AH; Pan, S; Surratt, CK; Ukairo, OT | 1 |
| Chen, R; Gu, HH; Han, DD | 1 |
| Ehrlich, ME; Niculescu, M; Unterwald, EM | 1 |
| Collins, SL; Evans, SM; Foltin, RW; Kleber, HD; Levin, FR | 1 |
| Arvanitogiannis, A; Augustyniak, PN; Kourrich, S; Rezazadeh, SM; Stewart, J | 1 |
| Burke, PJ; O'Sullivan, J; Vaughan, BL | 1 |
| Fukushima, S; Hall, FS; Kobayashi, H; Numachi, Y; Shen, HW; Sora, I; Uhl, GR; Yamashita, M | 1 |
| Biederman, J; Bonab, AA; Ciccone, PE; Dougherty, DD; Fischman, AJ; Livni, E; Madras, BK; Parasrampuria, DA; Spencer, TJ | 1 |
| Dhaliwal, SK; Guerriero, RM; Hayes, MM; Kosofsky, BE; Ren, JQ | 1 |
| Apparaju, S; Chiang, CN; Desai, P; Elkashef, A; Harrer, J; Horn, P; Mezinskis, J; Singal, BM; Somoza, E; Winhusen, T | 1 |
| Ehrman, LA; Gudelsky, GA; Schaefer, TL; Vorhees, CV; Williams, MT | 1 |
| Bello, NT; Hajnal, A | 1 |
| Benveniste, H; Du, C; Fowler, JS; Koretsky, AP; Volkow, ND; Yu, M | 1 |
| Huber, M; Karner, M; Kirchler, E; Pycha, R | 1 |
| Ramanujapuram, S; Surratt, CK; Ukairo, OT | 1 |
| Ikeda, K; Iwamura, T; Kobayashi, T; Nishizawa, D | 1 |
| Deutsch, HM; Kim, DI; Schweri, MM; Ye, X | 1 |
| Benveniste, H; Michaelides, M; Thanos, PK; Volkow, ND; Wang, GJ | 1 |
| Andreasen, JT; Hansen, HH; Mikkelsen, JD; Mirza, N; Scheel-Krüger, J; Weikop, P | 1 |
| Bevins, RA; Linkugel, JD; Reichel, CM | 1 |
| Steiner, H; Yano, M | 1 |
| Gold, MS; Kobeissy, FH; Svetlov, SI | 1 |
| Igari, M; Ikeda, K; Sora, I; Yamamoto, H | 1 |
| Fillmorex, MT; Hays, LR; Rush, CR; Vansickel, AR | 1 |
| Brennum, LT; Fink-Jensen, A; Hee Bengtsen, C; Petersen, JH; Sager, TN; Sørensen, G; Thomsen, M; Thøgersen, P; Woldbye, DP; Wörtwein, G | 1 |
| Gu, HH; Tilley, MR | 1 |
| Antapasis, J; Bolaños Guzmán, CA; Herrera, CM; Poveromo, LB; Wiley, MD | 1 |
| Baron, M; Greengard, P; Kim, Y; Nairn, AC; Sands, A; Teylan, MA | 1 |
| Bermeo, C; Grandy, DK; Rubinstein, M; Suchland, KL; Thanos, PK; Volkow, ND; Wang, GJ | 1 |
| Burton, CL; Fletcher, PJ; Nobrega, JN | 1 |
| Bergman, J; Desai, R; Desai, RI; Martin, J; Paronis, CA | 1 |
| Dow-Edwards, DL; Torres-Reveron, A; Weedon, J | 1 |
| Griggs, R; Koeltzow, TE; Wayman, W; Weir, C | 1 |
| Andersen, SL; Chen, YI; Choi, JK; Jenkins, BG; Ren, J; Xu, H | 1 |
| Der-Ghazarian, T; Herbert, MS; McDougall, SA; Palmer, AG | 1 |
| Alia-Klein, N; Fowler, JS; Goldstein, RZ; Jayne, M; Logan, J; Pradhan, K; Telang, F; Tomasi, D; Volkow, ND; Wang, GJ; Wong, C | 1 |
| Baella, SA; Campbell, RH; Crawford, CA; Farley, CM; Herbert, MS; Horn, LR; Zavala, AR | 1 |
| Dalley, JW; Economidou, D; Everitt, BJ | 1 |
| Poling, A | 1 |
| Bardo, MT; Booze, RM; Dwoskin, LP; Gomez, AM; Mactutus, CF; Midde, NM; Wooters, TE; Zhu, J | 1 |
| Alburges, ME; Fleckenstein, AE; Hanson, GR; Hoonakker, AJ; Horner, KA | 1 |
| Castellanos, KA; Greenfield, VY; Gutierrez, A; Horn, LR; Kozanian, OO; McDougall, SA; Mohd-Yusof, A | 1 |
| Figueredo, VM | 1 |
| Collins, GT; Cunningham, AR; Ko, MC; Narasimhan, D; Nichols, J; Sunahara, RK; Woods, JH; Zaks, ME | 1 |
| Bonab, AA; Clarke, A; Dougherty, DD; Fischman, AJ; Martin, J; Mirto, T; Spencer, TJ | 1 |
| Argento, JK; Arvanitogiannis, A; Flores, C | 1 |
| Broos, N; De Vries, TJ; Diergaarde, L; Pattij, T; Schoffelmeer, AN | 1 |
| Riley, AL; Wetzell, B | 1 |
| Calipari, ES; Ferris, MJ; Jones, SR; Mateo, Y; Melchior, JR; Roberts, DC | 1 |
| Bermejo, K; Calipari, ES; Ferris, MJ; Jones, SR; Melchior, JR; Roberts, DC; Salahpour, A | 1 |
| Levin, FR; Mariani, JJ | 1 |
| Bailey, JS; Eisener-Dorman, AF; Grabowski-Boase, L; Huitron-Resendiz, S; Roberts, AJ; Tarantino, LM; Wiltshire, T | 1 |
| Bisagno, V; Garcia-Rill, E; Goitia, B; González, LE; Raineri, M; Rozas, JL; Urbano, FJ | 1 |
| Berglund, EC; Ewing, AG; Heien, ML; Keighron, JD; Makos, MA; Phan, N | 1 |
| Czoty, PW; Gould, RW; Martelle, SE; Nader, MA | 1 |
| Fowler, JS; Han, H; Jayne, M; Kollins, SH; Logan, J; Newcorn, JH; Swanson, JM; Telang, F; Volkow, ND; Wang, GJ; Wigal, T; Wong, CT; Zhu, W | 1 |
| Buckley, NW; France, CP; Gosden, J; Hackett, D; Heal, DJ; Slater, N | 1 |
| Beverley, J; Steiner, H; Van Waes, V; Vandrevala, M | 1 |
| Arvanitogiannis, A; Yetnikoff, L | 1 |
| Calipari, ES; Caron, MG; Ferris, MJ; Jones, SR; Salahpour, A | 1 |
| Dunn, M; Federici, M; Feligioni, M; Gu, H; Latagliata, EC; Ledonne, A; Mercuri, NB; Nisticò, R; Puglisi-Allegra, S; Rizzo, FR; Sames, D; Sulzer, D | 1 |
| Anagnostaras, SG; Sage, JR; Shuman, T; Wood, S | 1 |
| Anagnostaras, SG; Carmack, SA; Howell, KK; Rasaei, K; Reas, ET | 1 |
| Alcantara, LF; Bolaños-Guzmán, CA; Iñiguez, SD; Parise, EM; Warren, BL | 1 |
| Calipari, ES; Ferris, MJ; Jones, SR; Siciliano, CA; Zimmer, BA | 1 |
| Calipari, ES; Jones, SR | 1 |
| Alexoff, DL; Du, C; Fowler, JS; Jayne, M; Logan, J; Tomasi, D; Volkow, ND; Wang, GJ; Wong, C; Yin, P | 1 |
| Gosden, J; Heal, DJ; Smith, SL | 1 |
| Calipari, ES; Ferris, MJ; Jones, SR; Siciliano, CA | 1 |
| Bryant, S; Dawson, BL; Doyle, HH; Helton, AK; Lloyd, SA; Picou, BN; Ross, JM; Schulz, J; Shanks, RA; Tavares, C | 1 |
| Belzung, C; Castelnau, P; Chalon, S; Cortese, S; Emond, P; Faraone, SV; Galineau, L; Lepelletier, FX; Nicolas, C; Solinas, M; Tauber, C | 1 |
| Rehavi, M; Simchon-Tenenbaum, Y; Weizman, A | 1 |
| Goldstein, RZ; Konova, AB; Moeller, SJ; Tomasi, D | 1 |
| Freissmuth, M; Hasenhuetl, PS; Koenig, X; Li, Y; Sandtner, W; Sarker, S; Schicker, K; Sitte, HH; Stockner, T; Sucic, S | 1 |
| Rehavi, M; Simchon Tenenbaum, Y; Weizman, A | 1 |
| Bao, YP; Ding, ZB; Han, Y; Jian, M; Liu, JF; Lu, L; Luo, YX; Shaham, Y; Shen, HW; Shi, HS; Shi, J; Wu, P; Xue, YX; Zhu, WL | 1 |
| Aalderink, M; Achterberg, EJ; Driel, NV; Houwing, DJ; Servadio, M; Trezza, V; van Kerkhof, LW; van Swieten, MM; Vanderschuren, LJ | 1 |
| Banks, ML; Schwienteck, KL | 1 |
| Baker, LE; Quisenberry, AJ | 1 |
| dos Santos Pereira, M; Fraga, MC; Kubrusly, R; Manhães, AC; Marques, RS; Peccinalli, NR; Sathler, MF; Valli, Tda R; Ventura, AL | 1 |
| Calipari, ES; Ferris, MJ; Fordahl, SC; Jones, SR; Karkhanis, AN; Weiner, JL; Yorgason, JT | 1 |
| Bisagno, V; González, B; Urbano, FJ | 1 |
| Aguilar, JI; Chen, A; Farino, ZJ; Fei, H; Flores, J; Freyberg, R; Freyberg, Z; Hiranita, T; Hsin, LW; Hu, G; Javitch, JA; Karam, CS; Katz, JL; Kopajtic, TA; Krantz, DE; Lin, YY; Martin, CA; McCabe, BD; Mosharov, EV; Pizzo, AB; Sames, D; Sonders, MS; Sulzer, D; Wimalasena, K; Zhang, Y | 1 |
| Bjarnadottir, GD; Bragadottir, H; Haraldsson, HM; Johannsson, M; Magnusson, A; Rafnar, BO; Sigurdsson, E; Steingrimsson, S | 1 |
| Andersen, SL; Freund, N; Lukkes, JL; Meda, S; Thompson, BS | 1 |
| Ananth, M; Hadjiargyrou, M; Komatsu, DE; Robison, LS; Thanos, PK | 1 |
| Baskin, BM; Dwoskin, LP; Kantak, KM; Nic Dhonnchadha, BÁ | 1 |
| Ewing, AG; Fletcher, JS; Malmberg, P; Phan, NTN; Philipsen, MH | 1 |
| Andersen, SL; Freund, N; Jordan, CJ; Lukkes, JL; Norman, KJ | 1 |
| Giancola, JB; Keighron, JD; Lin, SC; Newman, AH; Scaglione, A; Tanda, G; Zanettini, C | 1 |
| Blakely, RD; Carroll, FI; Davis, GL; Gowrishankar, R; Gresch, PJ; Hahn, MK; Katamish, RM; Peart, R; Rabil, MJ; Stewart, A | 1 |
| Johansen, SS; Linnet, K; Nedahl, M | 1 |
| Dunevall, J; Ewing, AG; Gu, C; Ren, L; Zhou, X; Zhu, W | 1 |
| Barbon, A; Bellucci, A; Benfenati, F; Bono, F; Bruno, A; Casiraghi, A; Costantino, G; Faustini, G; Grigoletto, J; La Via, L; Longhena, F; Missale, C; Pizzi, M; Spillantini, MG; Straniero, V; Valoti, E | 1 |
| Ewing, AG; Fletcher, JS; Phan, NTN; Philipsen, MH | 1 |
| Bi, GH; Chun, LE; Coggiano, MA; Hiranita, T; Jordan, CJ; Katz, JL; Keighron, JD; Lopez, JP; Mereu, M; Newman, AH; Quarterman, JC; Tanda, G; Xi, ZX | 1 |
| Arcadepani, FB; Bisaga, A; Fidalgo, TM; Gerra, G; Levin, FR; Tardelli, VS | 1 |
| De Serrano, AR; Hughes, KA; Rodd, FH | 1 |
| Arranz, B; Arrojo, M; Becoña, E; Bernardo, M; Castells, X; Cunill, R; Flórez, G; Fonseca, F; Garriga, M; Goikolea, JM; González-Pinto, A; López, A; Sáiz, PA; San, L; Tirado-Muñoz, J; Torrens, M; Zorrilla, I | 1 |
| Leyton, M | 1 |
| Acosta-Hernández, M; Cueto-Escobedo, J; García-García, F; López-Muciño, LA; Rodríguez-Alba, JC; Venebra-Muñoz, A | 1 |
| Aparicio Arias, J; Bertaso, F; Castell, L; Cutando, L; Hervé, D; Nakamura, Y; Rulhe, C; Tarot, P; Valjent, E | 1 |
| Baumann, MH; Gradisch, R; Hoffman, AF; Jäntsch, K; Kastner, N; Loland, CJ; Lubec, G; Lupica, CR; Maier, J; Niello, M; O Shea, R; Pollak, DD; Sandtner, W; Schwazer, J; Sideromenos, S; Sitte, HH; Stockner, T | 1 |
| Baumgartner, MR; Fischer, SKM; Müller, TJ; Mutschler, J; Perlov, E; Seifritz, E; Soyka, M; Tschudi, L | 1 |
| Angarita, GA; Ganesan, D; Gueorguieva, RR; Malison, RT; Marlin, B; Mayerson, TF; Nararajan, A; Parate, A; Pittman, B; Potenza, MN | 1 |
29 review(s) available for cocaine and methylphenidate
| Article | Year |
|---|---|
Discriminative response control by psychomotor stimulants.
Topics: Animals; Atropine; Central Nervous System Stimulants; Cinanserin; Cocaine; Dextroamphetamine; Discrimination, Psychological; DOM 2,5-Dimethoxy-4-Methylamphetamine; Methylphenidate; p-Hydroxyamphetamine; Phenoxybenzamine; Propranolol; Rats; Time Factors | 1976 |
Chronic cerebral effects of alcohol and drug abuse.
Topics: Alcoholism; Amphetamines; Barbiturates; Brain Diseases; Cannabis; Cerebrovascular Disorders; Cocaine; Humans; Hypnotics and Sedatives; Lysergic Acid Diethylamide; Mescaline; Methylphenidate; Narcotics; Phenmetrazine; Psilocybin; Psychological Tests; Psychoses, Alcoholic; Substance-Related Disorders | 1975 |
Addictiveness of central stimulants.
Topics: Amphetamines; Central Nervous System Stimulants; Cocaine; Euphoria; Humans; Methylphenidate; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Chronic neuropharmacology of cocaine: progress in pharmacotherapy.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine; Humans; Methylphenidate; Psychotherapy; Reward; Self Stimulation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Myocardial injury associated with polysubstance abuse.
Topics: Adult; Amphetamine; Cardiomyopathies; Cocaine; Drug Synergism; Electrocardiography; Female; Heroin; Humans; Male; Methylphenidate; Middle Aged; Substance-Related Disorders; Time Factors | 1988 |
Dopamine and psychotic states: preliminary remarks.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Carbon Radioisotopes; Cats; Cocaine; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Humans; Methylphenidate; Pemoline; Phenmetrazine; Pimozide; Psychoses, Substance-Induced; Psychotic Disorders; Rats; Receptors, Cell Surface; Species Specificity; Stereotyped Behavior; Thioridazine; Tyrosine | 1974 |
On stereotypy and catalepsy: studies on the effect of amphetamines and neuroleptics in rats.
Topics: Amphetamine; Animals; Basal Ganglia; Caffeine; Catalepsy; Cocaine; Compulsive Behavior; Corpus Striatum; Disease Models, Animal; Dopamine; Hippocampus; Humans; Lysergic Acid Diethylamide; Methamphetamine; Methylphenidate; Morphine; Norepinephrine; Pemoline; Phenmetrazine; Psychoses, Substance-Induced; Rats; Reserpine; Thalamus; Tranquilizing Agents | 1972 |
The spectrum of cocaine abuse and its treatment.
Topics: Ambulatory Care; Antidepressive Agents, Tricyclic; Behavior Therapy; Cocaine; Depressive Disorder; Hospitalization; Humans; Lithium; Lithium Carbonate; Methylphenidate; Psychiatric Status Rating Scales; Psychotherapy; Psychotic Disorders; Substance-Related Disorders | 1984 |
Cocaine abuse: a review of current and experimental treatments.
Topics: Animals; Antidepressive Agents, Tricyclic; Cocaine; Humans; Lithium; Lithium Carbonate; Methylphenidate; Psychotherapy; Substance-Related Disorders | 1984 |
Biochemistry and the schizophrenia. Old concepts and new hypothesis.
Topics: Acetylcholine; Amphetamine; Animals; Brain; Cocaine; Dopamine; Endorphins; gamma-Aminobutyric Acid; Humans; Methylphenidate; Naloxone; Norepinephrine; Phenethylamines; Physostigmine; Schizophrenia; Schizophrenia, Paranoid | 1981 |
Cocaine addiction: hypothesis derived from imaging studies with PET.
Topics: Animals; Brain; Carbon Radioisotopes; Cocaine; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Papio; Positron-Emission Tomography; Receptors, Dopamine D2; Substance-Related Disorders | 1996 |
Positron emission tomography studies of dopamine-enhancing drugs.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Selegiline; Tomography, Emission-Computed | 1999 |
The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate.
Topics: Amphetamines; Animals; Binding Sites; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Neurons | 2002 |
Ephedrine and other stimulants as ergogenic aids.
Topics: Amphetamine; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Doping in Sports; Ephedrine; Humans; Methylphenidate; Sports; Sympathomimetics | 2003 |
Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient.
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Cocaine; Dextroamphetamine; Humans; Methylphenidate; Reinforcement, Psychology; Substance-Related Disorders | 2003 |
Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD.
Topics: Attention Deficit Disorder with Hyperactivity; Brain; Cocaine; Delayed-Action Preparations; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Extracellular Space; Humans; Injections, Intravenous; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Reinforcement, Psychology; Self Medication; Substance-Related Disorders; Treatment Outcome | 2003 |
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Topics: Amphetamine; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Modafinil; Narcolepsy; Nicotine; Sleep; Wakefulness | 2004 |
Adolescent substance use: brief interventions by emergency care providers.
Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Chest Pain; Cocaine-Related Disorders; Crack Cocaine; Dangerous Behavior; Dyspnea; Emergencies; Humans; Male; Methylphenidate; Motivation; Professional-Patient Relations; Psychotherapy, Brief; Sex Work; Smoking; Substance Abuse Detection; Substance-Related Disorders; Surveys and Questionnaires | 2005 |
Methylphenidate and cocaine: the same effects on gene regulation?
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Gene Expression Regulation; Humans; Methylphenidate; Molecular Structure | 2007 |
Monoamine transporter as a target molecule for psychostimulants.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Methamphetamine; Methylphenidate; Mice; Mice, Knockout; Vesicular Monoamine Transport Proteins | 2007 |
Pharmacologic neuroimaging of the ontogeny of dopamine receptor function.
Topics: Adolescent; Adult; Aging; Amphetamine; Animals; Brain; Cerebrovascular Circulation; Cocaine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Magnetic Resonance Imaging; Male; Methylphenidate; Microdialysis; Phenanthridines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Regional Blood Flow | 2010 |
Chemical cardiomyopathies: the negative effects of medications and nonprescribed drugs on the heart.
Topics: Amphetamine; Anabolic Agents; Anthracyclines; Antineoplastic Agents; Cardiomyopathies; Chloroquine; Clozapine; Cocaine; Doxorubicin; Ephedra; Ethanol; Heart; Humans; Methylphenidate; Nonprescription Drugs; Prescription Drugs; Testosterone | 2011 |
Psychostimulant treatment of cocaine dependence.
Topics: Amphetamines; Animals; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clinical Trials as Topic; Cocaine; Cocaine-Related Disorders; Combined Modality Therapy; Dopamine Agents; Humans; Methylphenidate; Modafinil; Placebos; Rats; Reinforcement, Psychology; United States | 2012 |
Psychostimulants and cognition: a continuum of behavioral and cognitive activation.
Topics: Animals; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cocaine; Cognition; Humans; Methamphetamine; Methylphenidate; Modafinil | 2014 |
Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine.
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Humans; Methylphenidate | 2014 |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Humans; Methamphetamine; Methylphenidate; Modafinil; Nootropic Agents; Prefrontal Cortex; Substance-Related Disorders | 2016 |
Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
Topics: Amphetamine; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Humans; Lisdexamfetamine Dimesylate; Methylphenidate; Modafinil; Prescription Drugs; Randomized Controlled Trials as Topic; Substance-Related Disorders; Treatment Outcome | 2020 |
Clinical practice guideline on pharmacological and psychological management of adult patients with attention deficit and hyperactivity disorder and comorbid substance use.
Topics: Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine; Comorbidity; Humans; Methylphenidate; Substance-Related Disorders | 2022 |
Sleep loss and addiction.
Topics: Animals; Behavior, Addictive; Cocaine; Humans; Methylphenidate; Orexins; Sleep; Sleep Initiation and Maintenance Disorders | 2022 |
9 trial(s) available for cocaine and methylphenidate
| Article | Year |
|---|---|
The cognitive and psychomotor effects of opioid drugs in cancer pain management.
Topics: Adult; Amphetamines; Analgesics, Opioid; Buprenorphine; Central Nervous System Stimulants; Chronic Disease; Cocaine; Codeine; Cognition; Dextropropoxyphene; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Morphine; Neoplasms; Pain; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Thiazoles | 1994 |
Neurohormonal and behavioral response to methylphenidate in cocaine abstinence.
Topics: Adult; Arousal; Central Nervous System Stimulants; Cocaine; Dopamine; Drug Administration Schedule; Human Growth Hormone; Humans; Male; Methylphenidate; Neurologic Examination; Opioid-Related Disorders; Prolactin; Substance Withdrawal Syndrome | 1996 |
Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers.
Topics: Adult; Behavior; Blood Pressure; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Discrimination, Psychological; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Hypnotics and Sedatives; Male; Methylphenidate; Middle Aged; Psychomotor Performance; Surveys and Questionnaires; Triazolam | 2001 |
PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate.
Topics: Administration, Oral; Adolescent; Adult; Behavior, Addictive; Brain; Cocaine; Corpus Striatum; Delayed-Action Preparations; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Female; Humans; Male; Methylphenidate; Middle Aged; Osmosis; Positron-Emission Tomography; Substance Abuse Detection | 2006 |
Methylphenidate and cocaine: a placebo-controlled drug interaction study.
Topics: Adult; Cocaine; Cross-Over Studies; Drug Interactions; Electrocardiography; Female; Humans; Likelihood Functions; Male; Methylphenidate; Middle Aged; Placebos | 2006 |
Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Female; Humans; Inhibition, Psychological; Male; Methylphenidate; Modafinil; Reaction Time | 2008 |
One-trial cocaine-induced behavioral sensitization in preweanling rats: role of contextual stimuli.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Female; Locomotion; Male; Methylphenidate; Motor Activity; Neuroprotective Agents; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2010 |
Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers.
Topics: Adult; Blood Pressure; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Cues; Dopamine; Dopamine Uptake Inhibitors; Female; Fluorodeoxyglucose F18; Humans; Male; Methylphenidate; Middle Aged; Placebos; Positron-Emission Tomography | 2010 |
Understanding the central pharmacokinetics of spheroidal oral drug absorption system (SODAS) dexmethylphenidate: a positron emission tomography study of dopamine transporter receptor occupancy measured with C-11 altropane.
Topics: Administration, Oral; Adolescent; Adult; Brain; Carbon Radioisotopes; Cocaine; Delayed-Action Preparations; Dexmethylphenidate Hydrochloride; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Male; Methylphenidate; Middle Aged; Positron-Emission Tomography; Radioligand Assay | 2012 |
211 other study(ies) available for cocaine and methylphenidate
| Article | Year |
|---|---|
Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
Topics: Amnesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Humans; Male; Mice; Mice, Inbred Strains; Pyrrolidines; Structure-Activity Relationship | 1984 |
Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.
Topics: Animals; Cell Line; Crystallography, X-Ray; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Ketones; Male; Methylphenidate; Mice; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.
Topics: Cell Line, Tumor; Dopamine Plasma Membrane Transport Proteins; Humans; Ligands; Molecular Structure; Photoaffinity Labels; Pyrrolidines; Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Actions of amfonelic acid and other non-amphetamine stimulants on the dopamine neuron.
Topics: Amphetamines; Animals; Brain; Carboxylic Acids; Central Nervous System Stimulants; Cocaine; Dopamine; Methylphenidate; Nalidixic Acid; Naphthyridines; Rats; Receptors, Dopamine | 1976 |
The effects of psychomotor stimulants on single-spatial alternation behavior in dogs.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dextroamphetamine; Dogs; Female; Learning; Male; Methylphenidate; Phenmetrazine; Time Factors | 1979 |
A new device for the simultaneous measurement of locomotor and stereotypic frequency in mice.
Topics: Animals; Behavior; Body Weight; Cocaine; Dextroamphetamine; Humans; Male; Methylphenidate; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Psychology, Experimental; Stereotyped Behavior | 1979 |
Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice.
Topics: Animals; Avoidance Learning; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Cocaine; Drug Interactions; Male; Methamphetamine; Methylphenidate; Mice; Pentylenetetrazole; Strychnine | 1975 |
Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: a complex GABA-dopamine interaction.
Topics: Animals; Apomorphine; Basidiomycota; Behavior; Cocaine; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Methylphenidate; Methyltyrosines; Mice; Motor Activity; Oxazoles; Stereotyped Behavior | 1978 |
Interactions between depressants (alcohol-type) and stimulants (amphetamine-type).
Topics: Animals; Brain; Cocaine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Methylphenidate; Postural Balance; Rats; Time Factors | 1978 |
Comparison of inhibition of monoamine uptake by cocaine, methylphenidate and amphetamine.
Topics: Animals; Biogenic Amines; Brain; Cocaine; Desipramine; Dextroamphetamine; Dopamine; In Vitro Techniques; Male; Methylphenidate; Norepinephrine; Rats; Serotonin | 1978 |
Behavioral procedures for evaluating the relative abuse potential of CNS drugs in primates.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Haplorhini; Humans; Methylphenidate; Papio; Reinforcement, Psychology; Secobarbital; Substance-Related Disorders | 1976 |
Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.
Topics: Animals; Apomorphine; Benztropine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Cocaine; Dextroamphetamine; Dopamine; Dopamine Antagonists; Eating; Hydroxydopamines; Levodopa; Male; Methylphenidate; Methyltyrosines; Motor Activity; Rats; Spiperone; Telencephalon | 1977 |
Effects of amphetamine, methylphenidate and cocaine on serum prolactin concentrations in the male rat.
Topics: Animals; Cocaine; Depression, Chemical; Dextroamphetamine; Male; Methylphenidate; Prolactin; Rats | 1977 |
Methylphenidate-like effects of the new antidepressant drug nomifensine (HOE 984).
Topics: Animals; Antidepressive Agents; Apomorphine; Benztropine; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine; Humans; Isoquinolines; Male; Methylphenidate; Rats; Reserpine; Stereotyped Behavior; Synaptosomes; Time Factors | 1976 |
A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.
Topics: Animals; Choice Behavior; Cocaine; Decision Making; Dose-Response Relationship, Drug; Macaca mulatta; Male; Methylphenidate; Reinforcement Schedule | 1975 |
Comparison of progressive-ratio performance maintained by cocaine, methylphenidate and secobarbital.
Topics: Animals; Avoidance Learning; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Methylphenidate; Reinforcement Schedule; Secobarbital | 1975 |
Synthesis and pharmacology of irreversible affinity labels as potential cocaine antagonists: aryl 1,4-dialkylpiperazines related to GBR-12783.
Topics: Animals; Binding Sites; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; In Vitro Techniques; Isothiocyanates; Male; Methylphenidate; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiocyanates | 1992 |
[Characteristics of antagonism between ceruletide and various central-acting drugs: investigation by means of ambulatory activity in mice].
Topics: Animals; Bromocriptine; Caffeine; Ceruletide; Cocaine; Dose-Response Relationship, Drug; Drug Tolerance; Ephedrine; Haloperidol; Male; Methamphetamine; Methylphenidate; Mice; Morphine; Motor Activity; Scopolamine | 1990 |
Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluoxetine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Nalidixic Acid; Naphthyridines; Neurotransmitter Uptake Inhibitors; Norepinephrine; Nucleus Accumbens; Olfactory Bulb; Piperazines; Rats; Rats, Inbred Strains | 1990 |
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
Topics: Animals; Bupropion; Cocaine; Dopamine; Male; Mazindol; Methylphenidate; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Propiophenones; Saimiri; Self Administration | 1989 |
The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.
Topics: Animals; Cocaine; Dopamine; In Vitro Techniques; Kinetics; Male; Mazindol; Methylphenidate; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1989 |
The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801.
Topics: Animals; Behavior, Animal; Cocaine; Columbidae; Dextroamphetamine; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Haloperidol; Ketamine; Methylphenidate; Mice; Phencyclidine; Rats; Seizures; Structure-Activity Relationship | 1989 |
Discriminative properties of the psychostimulant dl-cathinone in a two lever operant task. Lack of evidence for dopaminergic mediation.
Topics: Alkaloids; Animals; Brain; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Cues; Dextroamphetamine; Discrimination Learning; Female; Generalization, Stimulus; Methylphenidate; Phenylpropanolamine; Piperidines; Rats | 1986 |
Relationships between drug-induced changes in tetrahydrobiopterin and biogenic amine concentrations in rat brain.
Topics: Animals; Biogenic Amines; Biopterins; Brain Chemistry; Circadian Rhythm; Cocaine; Corticotropin-Releasing Hormone; Dextroamphetamine; Male; Methylphenidate; Pteridines; Rats; Rats, Inbred Strains; Tryptophan; Valine | 1985 |
Methylphenidate treatment of cocaine abusers without attention deficit disorder: a negative report.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine; Humans; Male; Methylphenidate; Substance-Related Disorders | 1985 |
A study of the role of catecholamines in the response to various central stimulants.
Topics: Amphetamine; Animals; Apomorphine; Catalepsy; Catecholamines; Central Nervous System Stimulants; Cocaine; Dextroamphetamine; Drug Interactions; Ephedrine; Female; Humans; Methamphetamine; Methylphenidate; Methyltyrosines; Motor Activity; Phenmetrazine; Rats; Reserpine; Stereotyped Behavior | 1973 |
Neuropsychopharmacology of monoamines and their regulatory enzymes.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Apomorphine; Biogenic Amines; Brain; Cocaine; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Dopamine beta-Hydroxylase; Humans; Isoenzymes; Methylphenidate; Monoamine Oxidase; Neurons; Norepinephrine; Phenylethanolamine N-Methyltransferase; Schizophrenia; Serotonin; Tyrosine; Tyrosine 3-Monooxygenase | 1974 |
Effect of neurotropic agents on total pyridoxal phosphate and on the activity of the decarboxylose of aromatic amino acids as well as of other pyridoxal phosphate-dependent enzymes in rat brains.
Topics: Acetates; Amphetamine; Animals; Anti-Anxiety Agents; Atropine; Benzodiazepines; Brain; Carbon Radioisotopes; Carboxy-Lyases; Chloroform; Chlorpromazine; Cocaine; Dihydroxyphenylalanine; Ether; Female; Glutamates; Haloperidol; Hydroxylamines; Methylphenidate; Oxotremorine; Pentobarbital; Pentylenetetrazole; Pyridoxal Phosphate; Quinolines; Rats; Reserpine; Scopolamine; Semicarbazides; Theophylline; Tranylcypromine; Tyrosine Transaminase | 1974 |
Modification of vasodepressor responses to adrenaline by drugs.
Topics: Animals; Blood Pressure; Bretylium Compounds; Cocaine; Dogs; Epinephrine; Guanethidine; Isoproterenol; Methylphenidate; Nialamide; Reserpine; Sympatholytics; Tolazoline | 1965 |
Antagonism of the adrenergic neurone blocking action of guanethidine by certain antidepressant and antihistamine drugs.
Topics: Animals; Blood Pressure; Carotid Arteries; Cocaine; Dextroamphetamine; Dogs; Drug Antagonism; Guanethidine; Histamine H1 Antagonists; Hydrazines; Imipramine; Methamphetamine; Methylphenidate; Promethazine | 1966 |
Frequency-dependent potentiation by various drugs of the chronotropic response of isolated cat atria to sympathetic nerve stimulation.
Topics: Animals; Cats; Cocaine; Cycloparaffins; Electric Stimulation; Heart Atria; Hydrazines; Imipramine; In Vitro Techniques; Ketones; Methylphenidate; Monoamine Oxidase; Norepinephrine; Phenoxybenzamine; Transferases; Tritium | 1967 |
Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain; Caffeine; Central Nervous System; Cocaine; Lysergic Acid Diethylamide; Male; Methamphetamine; Methylphenidate; Nikethamide; Pemoline; Phenmetrazine; Piperidines; Rats | 1969 |
Conformational similarities between molecular models of phenethylamine and of potent inhibitors of the uptake of tritiated norepinephrine by adrenergic nerves in rabbit aorta.
Topics: Animals; Antidepressive Agents; Aorta; Chemical Phenomena; Chemistry; Cocaine; Desipramine; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylphenidate; Models, Structural; Norepinephrine; Nortriptyline; Phenethylamines; Piperidines; Rabbits; Sensory Receptor Cells; Sympathetic Nervous System; Tritium; Tyramine | 1970 |
Release of norepinephrine and normetanephrine from cat brain by central nervous system stimulants.
Topics: Amphetamine; Animals; Brain; Caffeine; Cats; Chlorine; Cocaine; Dextroamphetamine; Ephedrine; Methylphenidate; Norepinephrine; Normetanephrine; Piperidines; Tritium | 1970 |
Psychomotor stimulant self administration as a function of dosage per injection in the rhesus monkey.
Topics: Animals; Behavior, Animal; Cocaine; Haplorhini; Injections, Intravenous; Macaca; Methylphenidate; Phenmetrazine; Piperidines; Reinforcement, Psychology; Self Medication; Self Stimulation | 1971 |
The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey.
Topics: Amphetamine; Animals; Behavior, Animal; Chlorpromazine; Cocaine; Drug Antagonism; Humans; Macaca; Methylphenidate; Phenmetrazine; Piperidines; Self Stimulation; Stimulation, Chemical; Substance-Related Disorders | 1972 |
Further studies on the effect of various drugs on the uptake of tyramine-3H and formation of octopamine-3H in the rat heart.
Topics: Amitriptyline; Animals; Cocaine; Desipramine; Diphenhydramine; Female; Glucosyltransferases; Methylphenidate; Myocardium; Neurons; Norepinephrine; Octopamine; Pyridines; Rats; Sympathetic Nervous System; Triprolidine; Tritium; Tyramine | 1969 |
The induction and antagonism of central nervous system stimulant-induced stereotyped behavior in the cat.
Topics: Amphetamine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Benzyl Compounds; Cats; Central Nervous System; Cocaine; Dextroamphetamine; Dihydroxyphenylalanine; Drug Antagonism; Hydrazines; Methyldopa; Methylphenidate; Methyltyrosines; Pemoline; Reserpine; Serine; Stimulation, Chemical | 1972 |
Influence of 6-hydroxydopamine and of -methyl-p-tyrosine on the effects of some centrally acting agents.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Catecholamines; Cats; Chlorpromazine; Cocaine; Dopamine; Drug Antagonism; Female; Housing, Animal; Injections; Male; Methylphenidate; Methyltyrosines; Mice; Morphine; Motor Activity | 1972 |
A comparison of the effects of cocaine and synthetic central stimulants.
Topics: Amphetamine; Central Nervous System; Cocaine; Dextroamphetamine; Humans; Methylphenidate; Phenmetrazine | 1970 |
[Histochemical study of the effect of drugs on the uptake of alpha-methylnoradrenaline by noradrenaline and dopamine containing neurones in rats treated with reserpine].
Topics: Animals; Antidepressive Agents; Axons; Cocaine; Desipramine; Dopamine; Dopamine Antagonists; Guanethidine; Histocytochemistry; Hypothalamus; Iris; Male; Mesenteric Veins; Methylphenidate; Microscopy, Fluorescence; Monoamine Oxidase Inhibitors; Neurons; Norepinephrine; Normetanephrine; Rats; Reserpine; Tripelennamine; Vas Deferens | 1969 |
Anticholinergic activities of imipramine and methylphenidate.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Carbamates; Cats; Cocaine; Female; Imipramine; Male; Methylphenidate; Quaternary Ammonium Compounds; Salivation | 1969 |
Steric aspects of adrenergic drugs. XII. Some peripheral effects of (+-)-erythro- and (+-)-threo-methylphenidate.
Topics: Animals; Cats; Chemical Phenomena; Chemistry; Cocaine; Dibenzylchlorethamine; Drug Synergism; Fluorescence; In Vitro Techniques; Male; Methylphenidate; Muscle Contraction; Nictitating Membrane; Norepinephrine; Rats; Sensory Receptor Cells; Stereoisomerism; Tyramine; Vas Deferens | 1969 |
The anorexient activity of Kalio-kund (Dioscorea bulbifera Linn.), methylphenidate and cocaine in rats: a preliminary study.
Topics: Animals; Appetite Depressants; Cocaine; Feeding Behavior; Methylphenidate; Plant Extracts; Plants, Medicinal; Rats | 1969 |
Some factors determining the response of rabbit aortic strips to dl-norepinephrine-7-H3 hydrochloride and the influence of cocaine, guanethidine and methylphenidate on these factors.
Topics: Animals; Aorta; Cocaine; Guanethidine; In Vitro Techniques; Methylphenidate; Muscle, Smooth; Norepinephrine; Rabbits; Tritium | 1966 |
Four cases of progressive drug abuse.
Topics: Adult; Alcohols; Amphetamine; Barbiturates; Cannabis; Cocaine; Humans; Lysergic Acid Diethylamide; Male; Methylphenidate; Morphine; Opium; Substance-Related Disorders | 1967 |
Cocaine abuse and its treatment.
Topics: Antidepressive Agents; Behavior Therapy; Cocaine; Cognition; Conditioning, Psychological; Diazepam; Drug Tolerance; Family Therapy; Humans; Lithium; Methylphenidate; Psychoses, Substance-Induced; Psychotherapy; Self Concept; Sexual Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Methylphenidate (Ritalin) treatment of cocaine dependence--a preliminary report.
Topics: Adult; Cocaine; Female; Humans; Male; Methylphenidate; Substance-Related Disorders; Time Factors | 1984 |
Differential effects of d-amphetamine, beta-phenylethylamine, cocaine and methylphenidate on the rate of dopamine synthesis in terminals of nigrostriatal and mesolimbic neurons and on the efflux of dopamine metabolites into cerebroventricular perfusates o
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Central Nervous System Agents; Cerebral Ventricles; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Male; Methylphenidate; Neurons; Nucleus Accumbens; Olfactory Bulb; Phenethylamines; Rats; Rats, Inbred Strains | 1983 |
Cautionary note on methylphenidate for cocaine dependence.
Topics: Cocaine; Humans; Legislation, Drug; Methylphenidate; Substance-Related Disorders; United States | 1984 |
Self-stimulation and amphetamine: tolerance to d and l isomers and cross tolerance to cocaine and methylphenidate.
Topics: Amphetamine; Animals; Cocaine; Dextroamphetamine; Drug Tolerance; Male; Methylphenidate; Rats; Self Stimulation | 1981 |
Discriminative stimulus properties of a small dose of cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Male; Methylphenidate; Pentylenetetrazole; Rats | 1983 |
An extreme case of cocaine dependence and marked improvement with methylphenidate treatment.
Topics: Adult; Cocaine; Female; Humans; Methylphenidate; Self Concept; Self Medication; Substance-Related Disorders | 1983 |
The effect of altered dopaminergic activity on food intake in the rat: evidence for an optimal level of dopaminergic activity for behavior.
Topics: Amphetamine; Amphetamines; Animals; Apomorphine; Brain; Cocaine; Dextroamphetamine; Dopamine; Feeding Behavior; Haloperidol; Levodopa; Methylphenidate; Rats; Spiperone | 1980 |
Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain.
Topics: Adult; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Middle Aged; Nerve Tissue Proteins; Radioligand Assay; Sensitivity and Specificity; Tomography, Emission-Computed | 1995 |
Binding of d-threo-[11C]methylphenidate to the dopamine transporter in vivo: insensitivity to synaptic dopamine.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Presynaptic Terminals; Rats; Time Factors | 1995 |
Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier.
Topics: Amphetamine; Animals; Binding Sites; Carrier Proteins; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylmaleimide; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Neurons; Nomifensine; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1994 |
Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain.
Topics: Adult; Animals; Brain; Carbon Radioisotopes; Cerebellum; Cocaine; Corpus Striatum; Half-Life; Humans; Male; Methylphenidate; Middle Aged; Papio; Self Medication; Substance-Related Disorders; Time Factors; Tissue Distribution; Tomography, Emission-Computed | 1995 |
Binding of bromine-substituted analogs of methylphenidate to monoamine transporters.
Topics: Animals; Binding, Competitive; Bromine; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Microdialysis; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Tomography, Emission-Computed, Single-Photon | 1994 |
Plasma input function determination for PET using a commercial laboratory robot.
Topics: Animals; Benztropine; Blood Chemical Analysis; Carbon Radioisotopes; Cocaine; Fluorobenzenes; Humans; Methylphenidate; Papio; Phenols; Radioisotopes; Reproducibility of Results; Robotics; Selegiline; Tomography, Emission-Computed | 1995 |
Conformational analysis of methylphenidate and its structural relationship to other dopamine reuptake blockers such as CFT.
Topics: Cocaine; Crystallography, X-Ray; Dopamine Uptake Inhibitors; Methylphenidate; Molecular Structure; Stereoisomerism | 1995 |
Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs.
Topics: Animals; Cocaine; Dopamine; Male; Methylphenidate; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1996 |
Neurochemical mechanisms underlying responses to psychostimulants.
Topics: Animals; Behavior; Brain; Brain Chemistry; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Opioid-Related Disorders; Raclopride; Receptors, Dopamine; Research Design; Reward; Salicylamides; Substance-Related Disorders | 1996 |
Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Papio; Substance-Related Disorders; Synapses; Tomography, Emission-Computed | 1997 |
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects.
Topics: Adult; Behavior, Addictive; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Humans; Male; Methylphenidate; Raclopride; Salicylamides; Self-Assessment; Substance-Related Disorders; Thalamus; Tomography, Emission-Computed | 1997 |
Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Parkinson Disease; Primates; Radioligand Assay; Radiopharmaceuticals; Reference Values; Substance-Related Disorders; Tomography, Emission-Computed | 1998 |
Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations.
Topics: Animals; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Iodine Radioisotopes; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Papio; Radioligand Assay; Tomography, Emission-Computed | 1998 |
Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.
Topics: Animals; Carrier Proteins; Choice Behavior; Cocaine; Conditioning, Psychological; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Mice, Knockout; Nerve Tissue Proteins; Restriction Mapping; Reward; Serotonin Plasma Membrane Transport Proteins | 1998 |
Methylphenidate treatment for cocaine abusers with adult attention-deficit/hyperactivity disorder: a pilot study.
Topics: Adult; Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Cocaine; Cocaine-Related Disorders; Combined Modality Therapy; Comorbidity; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Male; Methylphenidate; Personality Inventory; Pilot Projects; Psychiatric Status Rating Scales; Secondary Prevention; Substance Abuse Detection | 1998 |
Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Motor Activity; Neostriatum; Nerve Tissue Proteins; Phencyclidine; Rats; Rats, Sprague-Dawley | 1998 |
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
Topics: Administration, Oral; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Papio; Tomography, Emission-Computed | 1998 |
Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of "high".
Topics: Adult; Aged; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Illicit Drugs; Injections, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Middle Aged; Nerve Tissue Proteins; Perception; Self Administration; Tomography, Emission-Computed; Visual Cortex | 1999 |
Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Female; Methylphenidate; Papio; Radioligand Assay; Synapses; Tomography, Emission-Computed | 1999 |
Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists?
Topics: Algorithms; Amphetamine; Animals; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrodes; In Vitro Techniques; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Neostriatum; Nerve Tissue Proteins; Phenethylamines; Rats; Rats, Sprague-Dawley | 1999 |
Indirect dopamine agonists augment the locomotor activating effects of the kappa-opioid receptor agonist U-50,488 in preweanling rats.
Topics: Age Factors; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Benzofurans; Cocaine; Dopamine Agonists; Drug Interactions; Female; Locomotion; Male; Methylphenidate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotyped Behavior | 1999 |
Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain.
Topics: Adult; Binding Sites; Blood Pressure; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Time Factors; Tomography, Emission-Computed | 1999 |
Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Central Nervous System Stimulants; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Infusion Pumps; Injections, Subcutaneous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tegmentum Mesencephali; Time Factors | 1999 |
Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Motor Activity; Nerve Tissue Proteins; Papio; Species Specificity | 1999 |
Dynamic changes in sensitivity occur during the acute response to cocaine and methylphenidate.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Chemistry; Caudate Nucleus; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Male; Methylphenidate; Microdialysis; Motor Activity; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Time Factors | 1999 |
[3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue.
Topics: Amphetamine; Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Tritium | 1999 |
Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor.
Topics: Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2000 |
Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biological Transport; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Methamphetamine; Methylphenidate; Models, Biological; Nerve Tissue Proteins; Norepinephrine; Onium Compounds; Organophosphorus Compounds; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Synaptosomes | 2001 |
Synthesis and pharmacology of site specific cocaine abuse treatment agents: a new synthetic methodology for methylphenidate analogs based on the Blaise reaction.
Topics: Animals; Biochemistry; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Drug Design; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methylphenidate; Molecular Structure; Rats; Structure-Activity Relationship | 2001 |
Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Methylphenidate; Motor Activity; Rats; Rats, Sprague-Dawley; Self Administration | 2001 |
Altered responsiveness to cocaine in rats exposed to methylphenidate during development.
Topics: Adaptation, Physiological; Adult; Aging; Animals; Central Nervous System Stimulants; Child; Cocaine; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Humans; Methylphenidate; Nucleus Accumbens; Rats; Receptors, AMPA; Reward; Time Factors | 2002 |
Cocaine-induced conditioned place preference in mice: induction, extinction and reinstatement by related psychostimulants.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Extinction, Psychological; Male; Methamphetamine; Methylphenidate; Mice; Phencyclidine | 2002 |
Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications.
Topics: Administration, Oral; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Behavior; Brain; Carbon Radioisotopes; Cardiovascular Physiological Phenomena; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extracellular Space; Humans; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Methylphenidate; Neostriatum; Nerve Tissue Proteins; Neurons; Raclopride; Tomography, Emission-Computed; Up-Regulation | 2002 |
5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Injections, Subcutaneous; Male; Mazindol; Methylphenidate; Motor Activity; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tropanes | 2002 |
Stereoselective effects of methylphenidate on motor hyperactivity in juvenile rats induced by neonatal 6-hydroxydopamine lesioning.
Topics: Animals; Autoradiography; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Methylphenidate; Motor Activity; Oxidopamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Sympathectomy, Chemical; Sympatholytics | 2002 |
Dopamine transporter-dependent induction of C-Fos in HEK cells.
Topics: Amphetamine; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Synergism; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger | 2002 |
Biodistribution study of [99mTc] TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautoradiography.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain; Cocaine; Dopamine Agents; Humans; Levodopa; Male; Methylphenidate; Mice; Mice, Inbred ICR; Organotechnetium Compounds; Parkinson Disease; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution; Tropanes | 2002 |
Pretreatment with methylphenidate sensitizes rats to the reinforcing effects of cocaine.
Topics: Animals; Catheters, Indwelling; Cocaine; Dose-Response Relationship, Drug; Male; Methylphenidate; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2002 |
Central stimulants as discriminative stimuli. Asymmetric generalization between (-)ephedrine and S(+)methamphetamine.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ephedrine; Generalization, Stimulus; Male; Methamphetamine; Methylphenidate; Propiophenones; Rats; Rats, Sprague-Dawley | 2002 |
Ceramide-induced alterations in dopamine transporter function.
Topics: Animals; Binding, Competitive; Ceramides; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Serotonin; Synaptosomes; Tritium | 2003 |
H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Attention; Avoidance Learning; Central Nervous System Stimulants; Cocaine; Cognition; Dextroamphetamine; Dose-Response Relationship, Drug; Histamine Antagonists; Male; Methylphenidate; Motor Activity; Piperidines; Rats; Rats, Inbred SHR; Receptors, Histamine H3 | 2003 |
Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood.
Topics: Age Factors; Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Male; Methylphenidate; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Psychomotor Performance; Reward; Substance Withdrawal Syndrome; Time Factors; Weight Gain | 2003 |
A comparison of some of the cardiovascular actions of methylphenidate and cocaine.
Topics: Cardiovascular System; Cocaine; Humans; Methylphenidate | 1959 |
Antagonism of guanethidine and bretylium by various agents.
Topics: Bretylium Compounds; Cocaine; Guanethidine; Hypertension; Methylphenidate; Monoamine Oxidase Inhibitors; Sympathomimetics | 1962 |
EFFECT OF DRUGS ON CONDITIONED AVOIDANCE RESPONSE IN RATS.
Topics: Avoidance Learning; Chlordiazepoxide; Chlorpromazine; Cocaine; Codeine; Conditioning, Operant; Ethanol; Hydroxyzine; Meperidine; Methylphenidate; Morphine; Pharmacology; Promethazine; Rats; Research; Sodium Salicylate | 1963 |
[COMPARISONS OF POSTGANGLIONAL ENERVATION WITH THE ACTION OF CERTAIN SUBSTANCES ON THE NICTITATING MEMBRANE OF THE CAT].
Topics: Amphetamine; Amphetamines; Animals; Bretylium Compounds; Cats; Cocaine; Epinephrine; Guanethidine; Methylphenidate; Nictitating Membrane; Norepinephrine; Pharmacology; Phenethylamines; Research; Reserpine; Sympathectomy; Tyramine | 1963 |
NOREPINEPHRINE STORAGE AND ACUTE TOLERANCE.
Topics: Adrenalectomy; Amphetamine; Amphetamines; Animals; Blood Pressure; Blood Pressure Determination; Cocaine; Dogs; Drug Tolerance; Electrocardiography; Methamphetamine; Methylphenidate; Norepinephrine; Pharmacology; Research; Splenectomy | 1963 |
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE.
Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine | 1964 |
ANTAGONISM OF CERTAIN EFFECTS OF CATECHOLAMINE-DEPLETING AGENTS BY ANTIDEPRESSANT AND RELATED DRUGS.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dogs; Dopamine; Electric Stimulation; Electrophysiology; Guanethidine; Imipramine; Metaraminol; Methylphenidate; Mice; Myocardium; Nictitating Membrane; Norepinephrine; Pharmacology; Piperidines; Promazine; Research; Reserpine; Tripelennamine; Tyrosine | 1964 |
[MODIFICATIONS OF EXCITABILITY OF THE VASOMOTOR CENTERS BY SUBSTANCES INTERFERING PERIPHERALLY WITH THE EFFECTS OF THE SYMPATHETIC NERVOUS SYSTEM].
Topics: Amphetamine; Amphetamines; Blood Pressure; Bretylium Compounds; Cats; Cocaine; Dibenzylchlorethamine; Diencephalon; Ephedrine; Ergotamine; Guanethidine; Hydrazines; Iproniazid; Isoproterenol; Medulla Oblongata; Methylphenidate; Monoamine Oxidase Inhibitors; Pharmacology; Phenoxybenzamine; Research; Sensory Receptor Cells; Sympathetic Nervous System; Sympatholytics; Yohimbine | 1964 |
POTENTIATION OF NOREPINEPHRINE IN THE ISOLATED VAS DEFERENS OF THE RAT BY SOME CNS STIMULANTS AND ANTIDEPRESSANTS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Cocaine; Desipramine; Humans; Imipramine; Male; Methylphenidate; Norepinephrine; Pharmacology; Phenmetrazine; Piperidines; Rats; Research; Tranquilizing Agents; Vas Deferens | 1965 |
EFFECT OF VARIOUS PRETREATMENTS ON RESPONSES TO EPHEDRINE ISOMERS.
Topics: Blood Pressure; Cocaine; Dogs; Ephedrine; Guanethidine; Heart; Heart Rate; Isomerism; Methylphenidate; Pharmacology; Piperidines; Research | 1965 |
ANTAGONISM OF THE BLOCKING ACTION OF BRETYLIUM AND GUANETHIDINE ON THE PRESSOR EFFECT OF PHYSOSTIGMINE IN THE RAT.
Topics: Amphetamine; Amphetamines; Blood Pressure; Bretylium Compounds; Cocaine; Dextroamphetamine; Guanethidine; Imipramine; Methylphenidate; Norepinephrine; Pharmacology; Physostigmine; Rats; Research; Reserpine; Sympatholytics; Vasoconstrictor Agents; Vasomotor System | 1965 |
Some interactions of guanethidine, cocaine, methylphenidate and phenylalkylamines in rabbit aortic strips.
Topics: Amidines; Amines; Animals; Antihypertensive Agents; Aorta; Calcium Channel Blockers; Cocaine; Guanethidine; Methylphenidate; Rabbits | 1962 |
Repeated methylphenidate treatment in adolescent rats alters gene regulation in the striatum.
Topics: Anesthetics, Local; Animals; Autoradiography; Cell Count; Central Nervous System Stimulants; Cocaine; Corpus Striatum; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Administration Schedule; Dynorphins; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Gene Silencing; Genes, fos; Immediate-Early Proteins; In Situ Hybridization; Male; Methylphenidate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance P; Transcription Factors | 2003 |
Effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of SHR rats. An in vivo microdyalisis study.
Topics: Amphetamine; Analysis of Variance; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Fluid; Male; Matched-Pair Analysis; Membrane Potentials; Methylphenidate; Microdialysis; Nucleus Accumbens; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2003 |
Enduring behavioral effects of early exposure to methylphenidate in rats.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Immobilization; Male; Methylphenidate; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time; Swimming; Time Factors | 2003 |
Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice.
Topics: Aging; Animals; Animals, Newborn; Benzazepines; Cocaine; Dopamine; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Immunoblotting; In Vitro Techniques; Male; Methamphetamine; Methylphenidate; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Signal Transduction; Threonine | 2003 |
Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Discrimination Learning; Dopamine Agents; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Methamphetamine; Methylphenidate; Microdialysis; Piperazines; Saimiri | 2004 |
Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration.
Topics: Administration, Oral; Adsorption; Animals; Brain; Carbon Radioisotopes; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Female; Isomerism; Male; Methylphenidate; Mice; Motor Activity; Papio; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed | 2004 |
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Cocaine; Desipramine; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Female; Infusion Pumps; Macaca mulatta; Methylphenidate; Propylamines; Reinforcement, Psychology; Self Administration; Substance-Related Disorders | 2005 |
Application of triple-probe microdialysis for fast pharmacokinetic/pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain.
Topics: Animals; Blood; Blood-Brain Barrier; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Agonists; Drug Administration Schedule; Extracellular Fluid; Male; Metabolic Clearance Rate; Methylphenidate; Microdialysis; Microelectrodes; Neurochemistry; Rats; Rats, Wistar; Time Factors; Up-Regulation | 2004 |
Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats.
Topics: Age Factors; Animals; Association Learning; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Electric Stimulation; Female; Long-Term Potentiation; Male; Medial Forebrain Bundle; Methylphenidate; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Stimulation | 2005 |
Actions of methylphenidate on dopaminergic neurons of the ventral midbrain.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Carbidopa; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Membrane Potentials; Mesencephalon; Methylphenidate; Neural Inhibition; Neurons; Rats; Reserpine; Sulpiride | 2005 |
Repeated administration of methylphenidate in young, adolescent, and mature rats affects the response to cocaine later in adulthood.
Topics: Age Factors; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Estrus; Female; Injections, Intraperitoneal; Locomotion; Male; Methylphenidate; Rats; Rats, Sprague-Dawley; Sex Factors; Stereotyped Behavior | 2005 |
Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol.
Topics: Animals; Cell Line; Cocaine; Dopamine Plasma Membrane Transport Proteins; Esterification; Ethanol; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Radioligand Assay; Receptors, Dopamine; Receptors, Serotonin; Stereoisomerism; Structure-Activity Relationship; Symporters | 2005 |
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Benztropine; Binding, Competitive; CHO Cells; Cocaine; Cricetinae; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Immunohistochemistry; Kinetics; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Microscopy, Confocal; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Transfection | 2005 |
A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate.
Topics: Amino Acid Substitution; Amphetamine; Animals; Biological Transport; Blotting, Western; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Haplorhini; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Mice, Knockout; Mutagenesis; Mutation; Nerve Tissue Proteins; Phenylalanine; Protein Structure, Tertiary; Radioligand Assay; Transfection; Tritium | 2005 |
Age-specific behavioral responses to psychostimulants in mice.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Male; Methylphenidate; Mice; Motor Activity; Stereotyped Behavior | 2005 |
Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD.
Topics: Administration, Oral; Adrenergic Agents; Adult; Attention Deficit Disorder with Hyperactivity; Choice Behavior; Cocaine; Cocaine-Related Disorders; Computers; Delayed-Action Preparations; Humans; Methylphenidate | 2006 |
Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Male; Methylphenidate; Nucleus Accumbens; Rats; Rats, Inbred SHR; Time Factors | 2006 |
Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.
Topics: Acoustic Stimulation; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Inhibition, Psychological; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Reaction Time; Reflex, Startle; Selective Serotonin Reuptake Inhibitors | 2006 |
Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Locomotion; Male; Methylphenidate; Mice; Pregnancy; Weight Gain | 2006 |
Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.
Topics: 3,4-Methylenedioxyamphetamine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Biogenic Monoamines; Body Weight; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Corticosterone; Electrochemistry; Female; Fenfluramine; Hippocampus; Immunoenzyme Techniques; Male; Maze Learning; Methamphetamine; Methylphenidate; Neurotransmitter Uptake Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley | 2006 |
Acute methylphenidate treatments reduce sucrose intake in restricted-fed bingeing rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Bulimia; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Eating; Energy Intake; Food Deprivation; Insulin; Male; Methylphenidate; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sucrose; Sulpiride | 2006 |
Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effects.
Topics: Anesthetics, Local; Animals; Blood Pressure; Body Temperature; Brain; Calcium; Cocaine; Dopamine Uptake Inhibitors; Female; Heart Rate; Hemoglobins; Heterocyclic Compounds, 3-Ring; Intracellular Fluid; Lidocaine; Methylphenidate; Rats; Rats, Sprague-Dawley; Spectrum Analysis | 2006 |
Delusional parasitosis and the dopamine transporter. A new insight of etiology?
Topics: Cocaine; Corpus Striatum; Delusions; Dopamine Plasma Membrane Transport Proteins; Humans; Methylphenidate; Models, Psychological; Parasitic Diseases; Pemoline; Protein Binding | 2007 |
Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Benztropine; Binding, Competitive; Brain; Brain Chemistry; Cell Line, Tumor; Chlorocebus aethiops; CHO Cells; Cocaine; Cocaine-Related Disorders; COS Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Mazindol; Methylphenidate; Neurons; Radioligand Assay | 2007 |
Inhibition by cocaine of G protein-activated inwardly rectifying K+ channels expressed in Xenopus oocytes.
Topics: Animals; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Electrophysiology; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Heart; Methamphetamine; Methylphenidate; Mice; Myocardium; N-Methyl-3,4-methylenedioxyamphetamine; Plasmids; Potassium Channel Blockers; RNA, Messenger; Xenopus laevis | 2007 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Male; Methylphenidate; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2007 |
Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents.
Topics: Animals; Body Weight; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine Antagonists; Dopamine Uptake Inhibitors; Magnetic Resonance Imaging; Male; Methylphenidate; Neostriatum; Positron-Emission Tomography; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Self Administration | 2007 |
The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine.
Topics: Animals; Carbamates; Central Nervous System Stimulants; Cocaine; Dopamine; Excitatory Amino Acid Antagonists; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Methylphenidate; Motor Activity; Phencyclidine; Phenylenediamines; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
Nicotine as a conditioned stimulus: impact of attention-deficit/hyperactivity disorder medications.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Bupropion; Cocaine; Conditioning, Operant; Conditioning, Psychological; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Psychological; Male; Methylphenidate; Nicotine; Nicotinic Antagonists; Piperazines; Propylamines; Rats; Rats, Sprague-Dawley | 2007 |
Performance enhancing, non-prescription use of Ritalin: a comparison with amphetamines and cocaine.
Topics: Amphetamines; Central Nervous System Stimulants; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Nonprescription Drugs; Psychomotor Performance | 2007 |
Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Male; Methylphenidate; Mice; Mice, Inbred Strains; Motivation; Motor Activity; Motor Skills; Piperazines; Quinolones; Radioligand Assay; Receptors, Dopamine D2; Self Administration | 2008 |
The effects of methylphenidate on knockin mice with a methylphenidate-resistant dopamine transporter.
Topics: Animals; Cocaine; Conditioning, Psychological; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Resistance; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Stereotyped Behavior | 2008 |
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Food Preferences; Male; Methylphenidate; Motor Activity; Naltrexone; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens.
Topics: Animals; Cocaine; Dendritic Spines; Fluorescent Dyes; Immunohistochemistry; Methylphenidate; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nucleus Accumbens; Proto-Oncogene Proteins c-fos | 2009 |
Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Exploratory Behavior; Genotype; Male; Methylphenidate; Mice; Mice, Knockout; Motor Activity; Random Allocation; Receptors, Dopamine D4 | 2010 |
The effects of adolescent methylphenidate self-administration on responding for a conditioned reward, amphetamine-induced locomotor activity, and neuronal activation.
Topics: Age Factors; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Early Growth Response Protein 1; Male; Methylphenidate; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward; RNA, Messenger; Self Administration | 2010 |
Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux.
Topics: Animals; Avoidance Learning; Biogenic Monoamines; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Male; Methamphetamine; Methylphenidate; Microdialysis; Motor Activity; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2010 |
Methylphenidate response in prenatal cocaine-exposed rats: a behavioral and brain functional study.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Female; Glucose; Male; Methylphenidate; Models, Animal; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sex Factors; Stereotyped Behavior | 2010 |
Intermittent methylphenidate during adolescent development produces locomotor hyperactivity and an enhanced response to cocaine compared to continuous treatment in rats.
Topics: Age Factors; Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Exploratory Behavior; Hyperkinesis; Male; Maze Learning; Methylphenidate; Rats; Rats, Sprague-Dawley | 2010 |
Early methylphenidate exposure enhances cocaine self-administration but not cocaine-induced conditioned place preference in young adult rats.
Topics: Age Factors; Animals; Choice Behavior; Cocaine; Conditioning, Operant; Conditioning, Psychological; Female; Male; Methylphenidate; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration; Sex Characteristics | 2011 |
Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seeking.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Cocaine; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Heroin; Male; Methylphenidate; Propylamines; Rats; Reinforcement Schedule; Self Administration | 2011 |
Progressive-ratio schedules and applied behavior analysis.
Topics: Animals; Behavior Therapy; Cocaine; Conditioning, Operant; Humans; Methylphenidate; Reinforcement Schedule; Reinforcement, Psychology | 2010 |
Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Environment; Male; Methylphenidate; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2011 |
Methylphenidate alters basal ganglia neurotensin systems through dopaminergic mechanisms: a comparison with cocaine treatment.
Topics: Animals; Basal Ganglia; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Male; Methylphenidate; Neurotensin; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2011 |
One-trial behavioral sensitization in preweanling rats: differential effects of cocaine, methamphetamine, methylphenidate, and D-amphetamine.
Topics: Aging; Animals; Animals, Suckling; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Male; Methamphetamine; Methylphenidate; Motor Activity; Rats; Rats, Sprague-Dawley; Weaning | 2011 |
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
Topics: Animals; Carboxylic Ester Hydrolases; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Food Preferences; Injections, Intraperitoneal; Ketamine; Male; Methylphenidate; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Sucrose; Sweetening Agents; Time Factors | 2012 |
Juvenile exposure to methylphenidate reduces cocaine reward and alters netrin-1 receptor expression in adulthood.
Topics: Animals; Animals, Newborn; Cocaine; Conditioning, Operant; Cues; DCC Receptor; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Receptors, Cell Surface; Reward; Tumor Suppressor Proteins; Ventral Tegmental Area | 2012 |
Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation.
Topics: Analysis of Variance; Animals; Benzazepines; Choice Behavior; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Antagonists; Dopamine Uptake Inhibitors; Extinction, Psychological; Impulsive Behavior; Male; Methylphenidate; Predictive Value of Tests; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Risk Factors; Secondary Prevention; Self Administration; Statistics as Topic; Time Factors | 2012 |
Adolescent exposure to methylphenidate has no effect on the aversive properties of cocaine in adulthood.
Topics: Animals; Avoidance Learning; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Male; Methylphenidate; Models, Animal; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration; Taste | 2012 |
Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate.
Topics: Animals; Bupropion; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Tolerance; Male; Methylphenidate; Nomifensine; Rats; Rats, Sprague-Dawley; Self Administration | 2012 |
Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations.
Topics: Animals; Blotting, Western; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrochemical Techniques; Male; Methylphenidate; Nucleus Accumbens; Phosphorylation; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Tyrosine 3-Monooxygenase | 2014 |
Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Corticosterone; Ethanol; Ethylnitrosourea; Female; Hypothalamo-Hypophyseal System; Male; Methylphenidate; Mice; Mice, Mutant Strains; Motor Activity; Mutagenesis; Pituitary-Adrenal System; Restraint, Physical; Reward; Self Administration; Species Specificity; Stress, Physiological | 2013 |
Differential effects of methylphenidate and cocaine on GABA transmission in sensory thalamic nuclei.
Topics: Animals; Blotting, Western; Central Nervous System Stimulants; Cocaine; gamma-Aminobutyric Acid; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Synaptic Transmission; Thalamic Nuclei | 2013 |
Oral administration of methylphenidate blocks the effect of cocaine on uptake at the Drosophila dopamine transporter.
Topics: Administration, Oral; Animals; Animals, Genetically Modified; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drosophila melanogaster; Male; Methylphenidate | 2013 |
Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Food; Injections, Intravenous; Macaca mulatta; Male; Methylphenidate; Reinforcement Schedule; Reinforcement, Psychology; Self Administration | 2013 |
Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Caudate Nucleus; Central Nervous System Stimulants; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Methylphenidate; Neuroimaging; Positron-Emission Tomography; Putamen; Radiopharmaceuticals; Young Adult | 2013 |
A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to D-amfetamine, methylphenidate and modafinil.
Topics: Animals; Benzhydryl Compounds; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Lisdexamfetamine Dimesylate; Methylphenidate; Modafinil; Rats; Reinforcement, Psychology; Self Administration | 2013 |
Selective serotonin re-uptake inhibitors potentiate gene blunting induced by repeated methylphenidate treatment: Zif268 versus Homer1a.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Combinations; Drug Synergism; Early Growth Response Protein 1; Fluoxetine; Homer Scaffolding Proteins; Male; Methylphenidate; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2014 |
Differential sensitivity to the acute and sensitizing behavioral effects of methylphenidate as a function of strain in adolescent and young adult rats.
Topics: Age Factors; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Male; Methylphenidate; Motor Activity; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Sexual Maturation; Species Specificity | 2013 |
Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression.
Topics: Administration, Oral; Amphetamines; Animals; Behavior, Animal; Brain; Central Nervous System Stimulants; Cocaine; Dopamine Plasma Membrane Transport Proteins; Gene Expression Regulation; Locomotion; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2013 |
Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Exocytosis; Methylphenidate; Mice; Phosphorylation; Synapsins; Synaptic Transmission | 2014 |
Animal model of methylphenidate's long-term memory-enhancing effects.
Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Bupropion; Central Nervous System Stimulants; Citalopram; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Fear; Female; Locomotion; Male; Maze Learning; Memory, Long-Term; Methylphenidate; Mice; Mice, Inbred C57BL; Nootropic Agents; Propylamines; Reinforcement, Psychology; Selective Serotonin Reuptake Inhibitors; Space Perception | 2014 |
Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice.
Topics: Animals; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Fluoxetine; Gene Expression; Male; MAP Kinase Signaling System; Methylphenidate; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Psychotropic Drugs; RNA, Messenger; Second Messenger Systems; Space Perception; Time Factors; Ventral Tegmental Area | 2014 |
Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter.
Topics: Amphetamine; Animals; Brain; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Methylphenidate; Nucleus Accumbens; Rats, Sprague-Dawley; Self Administration | 2014 |
Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration.
Topics: Amphetamine; Animals; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Methylphenidate; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, Dopamine D2; Self Administration; Substance-Related Disorders; Time Factors | 2014 |
Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers.
Topics: Brain; Brain Mapping; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cohort Studies; Craving; Cues; Dopamine; Dopamine Uptake Inhibitors; Humans; Male; Methylphenidate; Middle Aged; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals; Video Recording; Visual Perception | 2014 |
Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate.
Topics: Amphetamine; Animals; Biological Transport; Brain; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrochemical Techniques; Male; Methylphenidate; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Regression Analysis; Self Administration | 2015 |
Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Locomotion; Male; Methamphetamine; Methylphenidate; Mice; Mice, Inbred C57BL; Motor Activity; Sex Factors; Time Factors | 2015 |
Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats.
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Dietary Sucrose; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Female; Male; Methylphenidate; Motivation; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Wistar; Reward | 2014 |
Alterations in brain neurotrophic and glial factors following early age chronic methylphenidate and cocaine administration.
Topics: Age Factors; Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cocaine; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Locomotion; Male; Methylphenidate; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2015 |
Effects of chronic and acute stimulants on brain functional connectivity hubs.
Topics: Brain; Brain Mapping; Central Nervous System Stimulants; Chronic Disease; Cocaine; Cocaine-Related Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Methylphenidate; Neural Pathways; Rest | 2015 |
Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.
Topics: Binding Sites; Cocaine; Desipramine; Dopamine Plasma Membrane Transport Proteins; HEK293 Cells; Humans; Methylphenidate; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Serotonin Plasma Membrane Transport Proteins | 2015 |
The Impact of Chronic Early Administration of Psychostimulants on Brain Expression of BDNF and Other Neuroplasticity-Relevant Proteins.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cocaine; Doublecortin Domain Proteins; Doublecortin Protein; Male; Methylphenidate; Microtubule-Associated Proteins; Neuronal Plasticity; Neuropeptides; Rats; Rats, Sprague-Dawley; Synaptophysin; tau Proteins | 2015 |
A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.
Topics: Animals; Basolateral Nuclear Complex; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Cues; Drug-Seeking Behavior; Endocytosis; Extinction, Psychological; Inhibition, Psychological; Male; Mental Recall; Methylphenidate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recurrence; Self Administration | 2015 |
Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Cocaine; Conditioning, Operant; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Flupenthixol; Idazoxan; Male; Methylphenidate; Motivation; Neuropsychological Tests; Norepinephrine; Piperazines; Random Allocation; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Dopamine; Social Behavior | 2016 |
Effects of 7-day continuous D-amphetamine, methylphenidate, and cocaine treatment on choice between methamphetamine and food in male rhesus monkeys.
Topics: Animals; Choice Behavior; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Food; Macaca mulatta; Male; Methamphetamine; Methylphenidate; Self Administration | 2015 |
Dopaminergic mediation of the discriminative stimulus functions of modafinil in rats.
Topics: Amphetamine; Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dextroamphetamine; Dopamine; Dopamine Agents; Generalization, Psychological; Male; Methylphenidate; Modafinil; Nicotine; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Wakefulness-Promoting Agents | 2015 |
Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Biological Transport; Central Nervous System Stimulants; Cocaine; Cyclic AMP; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Methylphenidate; Prefrontal Cortex; Rats; Rats, Inbred SHR; Receptors, Dopamine D1 | 2015 |
Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum.
Topics: Age Factors; Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Methylphenidate; Rats; Rats, Long-Evans; Social Isolation | 2016 |
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.
Topics: Amphetamine; Animals; Animals, Genetically Modified; Brain; Cocaine; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Drosophila melanogaster; HEK293 Cells; Humans; Image Processing, Computer-Assisted; Locomotion; Methamphetamine; Methylphenidate; Optical Imaging; Rats; Synaptic Vesicles; Vesicular Monoamine Transport Proteins | 2016 |
Intravenous Use of Prescription Psychostimulants; A Comparison of the Pattern and Subjective Experience between Different Methylphenidate Preparations, Amphetamine and Cocaine.
Topics: Administration, Intravenous; Adult; Amphetamine; Central Nervous System Stimulants; Cocaine; Cross-Sectional Studies; Delayed-Action Preparations; Drug Compounding; Euphoria; Female; Humans; Iceland; Male; Methylphenidate; Prescription Drug Misuse; Young Adult | 2016 |
Preventative treatment in an animal model of ADHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Delay Discounting; Disease Models, Animal; Dopamine; Female; Gonadal Hormones; Impulsive Behavior; Methylphenidate; Ovariectomy; Oxidopamine; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Neurotransmitter; RNA, Messenger | 2016 |
Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats.
Topics: Administration, Oral; Animals; Autoradiography; Benzazepines; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Methylphenidate; Radiopharmaceuticals; Rats, Inbred SHR; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tritium | 2017 |
Blockade of α2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Age Factors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Cocaine; Cocaine-Related Disorders; Male; Methylphenidate; Prefrontal Cortex; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Self Administration; Species Specificity | 2017 |
Mass Spectrometry Imaging Shows Cocaine and Methylphenidate Have Opposite Effects on Major Lipids in Drosophila Brain.
Topics: Animals; Brain; Cocaine; Drosophila; Drosophila melanogaster; Lipid Metabolism; Methylphenidate; Phosphatidylethanolamines; Principal Component Analysis; Spectrometry, Mass, Secondary Ion | 2018 |
Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior.
Topics: Adrenergic alpha-2 Receptor Agonists; Age Factors; Animals; Behavior, Addictive; Cocaine; Delay Discounting; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Guanfacine; Impulsive Behavior; Male; Methylphenidate; Motivation; Rats; Rats, Sprague-Dawley; Self Administration; Sex Characteristics | 2019 |
Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors.
Topics: Animals; Central Nervous System Agents; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electroencephalography; Heroin; Ketamine; Male; Methylphenidate; Modafinil; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2019 |
Serotonin transporter inhibition and 5-HT
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Locomotion; Methylphenidate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Neostriatum; Receptor, Serotonin, 5-HT2C; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2019 |
Postmortem Brain-Blood Ratios of Amphetamine, Cocaine, Ephedrine, MDMA and Methylphenidate.
Topics: Amphetamine; Autopsy; Brain Chemistry; Calibration; Cocaine; Forensic Toxicology; Gray Matter; Humans; Methylphenidate; N-Methyl-3,4-methylenedioxyamphetamine; Postmortem Changes; Reference Standards; Reproducibility of Results | 2019 |
Combined Amperometry and Electrochemical Cytometry Reveal Differential Effects of Cocaine and Methylphenidate on Exocytosis and the Fraction of Chemical Release.
Topics: Animals; Biosensing Techniques; Cocaine; Dopamine Uptake Inhibitors; Electrochemical Techniques; Electrodes; Exocytosis; Methylphenidate; PC12 Cells; Rats | 2019 |
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.
Topics: alpha-Synuclein; Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Gait Disorders, Neurologic; Lewy Bodies; Methylphenidate; Mice; Mice, Inbred C57BL; Parkinson Disease; Substantia Nigra; Synapsins; Synucleinopathies | 2020 |
Interplay between Cocaine, Drug Removal, and Methylphenidate Reversal on Phospholipid Alterations in
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Drosophila; Drosophila melanogaster; Methylphenidate; Pharmaceutical Preparations; Phospholipids; Spectrometry, Mass, Secondary Ion | 2020 |
Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Dose-Response Relationship, Drug; Gap Junctions; Methylphenidate; Modafinil; Rats; Rats, Sprague-Dawley | 2020 |
Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies.
Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Cocaine; Epigenomics; Exploratory Behavior; Female; Humans; Male; Methylphenidate; Models, Animal; Paternal Exposure; Poecilia; Rodentia; Sex Factors | 2021 |
Do stimulant medications produce sensitization in humans?
Topics: Central Nervous System Stimulants; Cocaine; Humans; Methylphenidate | 2022 |
Psychostimulant Drugs Activate Cell-type Specific and Topographic cFos Expression in the Lumbar Spinal Cord.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Dextroamphetamine; Male; Methylphenidate; Mice; Pharmaceutical Preparations; Spinal Cord | 2023 |
Persistent binding at dopamine transporters determines sustained psychostimulant effects.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Methylphenidate; Mice | 2023 |
Concomitant Drug Use among Opioid-Dependent Patients with and without Attention Deficit Hyperactivity Disorder: Does Methylphenidate Merit a Trial?
Topics: Amphetamine; Analgesics, Opioid; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cross-Sectional Studies; Heroin; Humans; Methylphenidate; N-Methyl-3,4-methylenedioxyamphetamine; Substance-Related Disorders; Treatment Outcome | 2023 |
Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors.
Topics: Cocaine; Cocaine-Related Disorders; Electrocardiography; Humans; Methylphenidate; Sympathomimetics; Wearable Electronic Devices | 2023 |