cocaine has been researched along with glutamic acid in 298 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 35 (11.74) | 18.2507 |
| 2000's | 117 (39.26) | 29.6817 |
| 2010's | 114 (38.26) | 24.3611 |
| 2020's | 32 (10.74) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Hertz, L; Peng, L | 1 |
| Berretta, S; Graybiel, AM; Robertson, HA | 1 |
| Koob, GF; Maldonado-Lopez, R; Pulvirenti, L | 1 |
| Karpiak, SE; MacDonall, JS; Mahadik, SP; Stadlin, A; Tsang, D | 1 |
| Jimenez-Rivera, CA; Waterhouse, BD | 1 |
| Koob, GF; Pulvirenti, L; Swerdlow, NR | 1 |
| Bansinath, M; Garg, UC; Turndorf, H | 1 |
| Harris, GC; Imel, KM; Wheaton, MJ; White, SR | 1 |
| Guo, H; Kunko, PM; Mo, Q; Robinson, SE; Smith, JA | 1 |
| Kunko, PM; Maher, JR; McDowell, KP; Robinson, SE | 1 |
| Duffy, P; Kalivas, PW | 2 |
| Hu, XT; White, FJ; Wolf, ME; Zhang, XF | 2 |
| Bedingfield, JB; Calder, LD; Karler, R; Thai, LH | 1 |
| Bedingfield, JB; Calder, LD; Karler, R | 1 |
| Bolinao, ML; Moghaddam, B | 1 |
| Witkin, JM | 1 |
| Harper, RM; Kristensen, MP; Nitz, DA; Poe, GR; Rector, DM | 1 |
| Berger, SP; Reid, MS | 1 |
| Gallagher, JP; McDaniel, WC; Shoji, S; Simms, D | 1 |
| Kunko, PM; Maher, JR; Mo, Q; Robinson, SE; Smith, JA; Wallace, MJ | 1 |
| DiPirro, JM; Horowitz, JM; Kristal, MB; Torres, G | 1 |
| Berger, SP; Hsu, K; Reid, MS | 1 |
| Hicks, J; Kalivas, PW; Morgan, ZR; Pierce, RC; Reeder, DC | 1 |
| Kosten, TR | 1 |
| Wickelgren, I | 1 |
| Rockhold, RW | 1 |
| Cheramy, A; Cole, DG; Cooper, DC; Corbett, R; Fienberg, AA; Girault, J; Grace, AA; Greengard, P; Haile, CN; Hiroi, N; Hyman, SE; Mermelstein, PG; Miller, DB; Nestler, EJ; Nishi, A; O'Callaghan, JP; Onn, SP; Ouimet, CC; Snyder, GL; Song, W; Surmeier, DJ; White, FJ | 1 |
| Ellison, G; Emre, N; Meshul, CK; Noguchi, K | 1 |
| Bockaert, J; Manzoni, O; Pujalte, D; Williams, J | 1 |
| Emre, N; Keys, AS; Mark, GP; Meshul, CK | 1 |
| Ghasemzadeh, MB; Kalivas, PW; Lu, XY; Nelson, LC | 1 |
| Burton, FH; Campbell, KM; McGrath, MJ | 1 |
| Cornish, JL; Duffy, P; Kalivas, PW | 1 |
| Dohi, T; Ikeda, T; Kitayama, S; Mitsuhata, C; Morita, K; Sato, T | 1 |
| Callahan, B; Hatzidimitriou, G; Kim, S; Ricaurte, GA; Westphalen, R; Yuan, J | 1 |
| Cornish, JL; Kalivas, PW | 2 |
| Bell, K; Duffy, P; Kalivas, PW | 1 |
| Co, C; Sizemore, GM; Smith, JE | 1 |
| Dalley, JW; Everitt, BJ; Howes, SR; Morrison, CH; Robbins, TW | 1 |
| Jiménez, Z; Jiménez-Rivera, CA; Segarra, O; Waterhouse, BD | 1 |
| Gardner, EL; Hayes, RJ; Liu, X; Spector, JA; Vorel, SR | 1 |
| Holden, C | 1 |
| Gether, U; Loland, CJ; Norregaard, L | 1 |
| Nestler, EJ | 1 |
| Angulo, JA; Loonam, TM; Noailles, PA; Zhang, Y | 1 |
| Kozell, LB; Meshul, CK | 2 |
| Stavale, JN; Villares, JC | 1 |
| Berke, JD; Hyman, SE; Krause, M; Lavoie, B; Sgambato, V; Vincent, M; Zhu, PP | 1 |
| Baker, DA; Carson, D; Kalivas, PW; Swanson, CJ; Worley, PF | 1 |
| Giorgetti, M; Hotsenpiller, G; Wolf, ME | 1 |
| Anderson, SM; Bari, AA; Jey, AR; Park, WK; Pierce, RC; Rowlett, JK; Spealman, RD | 1 |
| Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA; Runkel, F; Sucic, S | 1 |
| Abreu, R; Almodóvar-Fabregas, LJ; Colón, N; Dones, JG; Jiménez-Rivera, CA; Mejías-Aponte, CA; Mercado, M; Segarra, O; Vázquez, E; Vázquez, R; Williams, JT | 1 |
| Li, N; Sorg, BA; Wu, WR | 1 |
| Inoue, O; Kagawa, S; Nakano, T; Nishimura, T | 1 |
| Canales, JJ; Capper-Loup, C; Choe, ES; Graybiel, AM; Hu, D; Upadhyay, U | 1 |
| Baker, DA; Kalivas, PW; Shen, H | 1 |
| Baker, DA; Kalivas, PW; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX | 1 |
| Kozell, B; Meshul, K | 1 |
| Aston-Jones, G; Harris, GC | 1 |
| Hotsenpiller, G; Wolf, ME | 2 |
| Licata, SC; Pierce, RC | 1 |
| Kalivas, PW; Lake, R; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX | 1 |
| Kalivas, PW; Lapish, CC; McFarland, K | 1 |
| Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S | 1 |
| Ding, JH; Gu, B; He, HR; Hu, G; Liu, Y; Wang, H | 1 |
| Backes, E; Hemby, SE | 1 |
| Berfield, JL; Chen, N; Reith, ME; Rickey, J | 1 |
| Hayase, T; Yamamoto, K; Yamamoto, Y | 1 |
| Davidge, SB; Kalivas, PW; Lapish, CC; McFarland, K | 1 |
| Frys, KA; Kalivas, PW; Szumlinski, KK | 1 |
| Hope, BT; Kreuter, JD; Mattson, BJ; Wang, B; You, ZB | 1 |
| O'Dell, LE; Parsons, LH | 1 |
| Jayaram, P; Steketee, JD | 1 |
| Berry, T; Champtiaux, NP; Dehoff, MH; During, MJ; Frys, KA; Griffin, W; Kalivas, PW; Kang, SH; Klugmann, M; Lominac, KD; Middaugh, LD; Rohrer, J; Shealy, SE; Szumlinski, KK; Toda, S; Tu, JC; Worley, PF | 1 |
| Steketee, JD; Williams, JM | 1 |
| Caboche, J; Corvol, JC; Enslen, H; Girault, JA; Greengard, P; Hervé, D; Lombroso, PJ; Nairn, AC; Pascoli, V; Paul, S; Stipanovich, A; Svenningsson, P; Valjent, E | 1 |
| Abarca, C; Albrecht, U; Depner, M; Holzberg, D; Lascorz, J; Lathrop, M; Magnone, MC; Matsuda, F; Pendyala, G; Sanchis-Segura, C; Schreiber, S; Schumann, G; Soyka, M; Spanagel, R; Zghoul, T | 1 |
| Bart, G; Kreek, MJ; Yuferov, V | 1 |
| Dallimore, JE; Mackie, AR; McDaid, J; Mickiewicz, AL; Napier, TC | 1 |
| Furuyashiki, T; Miyakawa, T; Mizuma, H; Morishima, Y; Nakanishi, S; Tanaka, Y | 1 |
| McKee, BL; Meshul, CK | 1 |
| Fukumoto, D; Harada, N; Kakiuchi, T; Nishiyama, S; Tsukada, H | 1 |
| Kalivas, PW; McFarland, K; Melendez, RI; Moran, MM; Seamans, JK | 1 |
| Heusner, CL; Palmiter, RD | 1 |
| Abernathy, KE; During, M; He, DY; Kalivas, PW; Klugmann, M; Lominac, KD; Oleson, EB; Ron, D; Szumlinski, KK | 1 |
| Olsen, CM; Schramm-Sapyta, NL; Winder, DG | 1 |
| Anderson, SM; Famous, KR; Kumaresan, V; Pierce, RC; Schmidt, HD | 1 |
| Kruzich, PJ; Xi, J | 1 |
| Becker, N; Mead, AN; Stephens, DN; Zamanillo, D | 1 |
| Rebec, GV; Sun, W | 1 |
| Dar, DE; Metzger, TG; Uhl, GR; Vandenbergh, DJ | 1 |
| Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Wetsel, WC; Zhang, X | 1 |
| Cao, C; Ding, JH; Gao, L; Hu, G; Li, Z; Liu, Q; Sun, XL | 1 |
| Steketee, JD | 1 |
| Gardner, EL; Gilbert, JG; Li, X; Pak, AC; Peng, XQ; Xi, ZX | 1 |
| Gallagher, JP; Grigoriadis, DE; Liu, J; Orozco-Cabal, L; Pollandt, S; Shinnick-Gallagher, P; Vale, WW | 1 |
| Kalivas, PW; Melendez, RI; Murphy, TH; Pacchioni, AM; Shih, A; Vallone, J | 1 |
| Chu, XP; Fibuch, EE; Haines, M; Lan, HX; Li, MH; Liu, F; Liu, XY; Mao, LM; Neve, KA; Parelkar, NK; Wang, JQ; Wang, M; Xiong, ZG; Zhang, GC | 1 |
| Bedogni, F; Collu, M; Fadda, P; Fresu, A; Racagni, G; Riva, MA | 1 |
| Ben-Shahar, O; Brake, W; Cook, M; Ettenberg, A; Heston, R; Joyce, M; Keeley, P; Nyffeler, M | 1 |
| Allen, RM; Carelli, RM; Dykstra, LA | 1 |
| Biswas, S; Harlan, RE; Neisewander, JL; Zavala, AR | 1 |
| Boutros, N; Stanley, J; Sundaresan, K; Ziemann, U | 1 |
| Battista, N; Bernardi, G; Centonze, D; De Chiara, V; Maccarrone, M; Mercuri, NB; Prosperetti, C; Rossi, S; Usiello, A | 1 |
| Haynes, JM; Pouton, CW; Raye, WS; Tochon-Danguy, N | 1 |
| Rice, KC; Wang, B; Wise, RA; You, ZB | 1 |
| Famous, KR; Pierce, RC; Schmidt, HD | 1 |
| Ali, YM; Cheng, RK; Meck, WH | 1 |
| Bonci, A; Borgland, SL; Kharazia, VN; Sarti, F | 1 |
| Gass, JT; Olive, MF | 1 |
| Ary, AW; Lominac, KD; Szumlinski, KK | 1 |
| Furushima, K; Kitano, J; Kiyonari, H; Miyakawa, T; Moriyoshi, K; Nakamura, K; Nakanishi, S; Nakao, K; Nakayama, R; Ogawa, M | 1 |
| Gao, F; Jiao, H; Lou, D; Xu, M; Zhang, J; Zhang, L | 1 |
| Azari, S; Wang, B; Wise, RA; You, ZB; Zitzman, D | 1 |
| Ambrosio, E; Del Olmo, N; García-Lecumberri, C; Higuera-Matas, A; Miguéns, M; Torres, I | 1 |
| McElligott, ZA; Winder, DG | 1 |
| Bernard, F; Caboche, J; Kappes, V; Lavaur, J; Pagès, C; Pascoli, V; Trifilieff, P; Vanhoutte, P | 1 |
| Camarini, R; Griffin, WC; Olive, MF; Rosalina dos Santos, B; Yanke, AB | 1 |
| Anderson, SM; Bass, CE; Cha, JH; Famous, KR; Kumaresan, V; Pierce, RC; Sadri-Vakili, G; Schmidt, HD; Terwilliger, EF | 1 |
| Kalivas, PW | 1 |
| Arth, C; Ary, AW; Fowler, JK; Penzner, JH; Szumlinski, KK; Thompson, DL | 1 |
| Ferrario, CR; Kennedy, RT; Robinson, TE; Samaha, AN; Shou, M; Watson, CJ | 1 |
| Kalivas, PW; Tang, XC; Torregrossa, MM | 1 |
| Crombag, HS; Ferrario, CR; Robinson, TE | 1 |
| Bian, S; Choe, ES; Lee, DK; Rahman, MA; Shim, I; Shim, YB | 1 |
| Wise, RA | 1 |
| Abdulhameed, O; Baker, DA; Grier, MD; Kau, KS; Madayag, A; Mantsch, JR | 1 |
| Placenza, FM; Rajabi, H; Stewart, J | 1 |
| Steketee, JD; Xie, X | 1 |
| Wang, B; Wise, RA; You, ZB | 2 |
| Kalivas, PW; Pacchioni, AM; Vallone, J; Worley, PF | 1 |
| Acker, CJ; Ghasemzadeh, MB; Kalivas, PW; Lake, RW; Windham, LK | 1 |
| Bachtell, RK; Self, DW | 1 |
| Kalivas, PW; Mohan, A; Nair, SS; Pendyam, S | 1 |
| Kash, TL; Matthews, RT; Nobis, WP; Winder, DG | 1 |
| Ghasemzadeh, MB; Mantsch, JR; Mueller, C; Seubert, C; Vasudevan, P | 1 |
| LaLumiere, RT; Uys, JD | 1 |
| Kalivas, PW; Knackstedt, LA | 1 |
| Agovic, MS; Banerjee, SP; Friedman, E; Gashi, E; Lidsky, TI; Yablonsky-Alter, E | 1 |
| Hsu, KS; Huang, CC; Lee, CC; Liang, YC; Wu, MY | 1 |
| Berglind, WJ; Kalivas, PW; LaLumiere, RT; McGinty, JF; Whitfield, TW | 1 |
| Ecke, LE; Suto, N; Wise, RA | 1 |
| Creton, C; Engblom, D; Halbout, B; Lüscher, C; Mameli, M; Parkitna, JR; Spanagel, R | 1 |
| Dow-Edwards, D; Siegal, N | 1 |
| Lawrence, AJ; Mantamadiotis, T; McPherson, CS; Tan, SS | 1 |
| Kalivas, PW; Knackstedt, LA; Melendez, RI | 1 |
| Berglind, WJ; McGinty, JF; Whitfield, TW | 1 |
| Ashby, CR; Chun, L; Gardner, EL; Li, J; Li, X; Peng, XQ; Slusher, BS; Thomas, AG; Xi, ZX | 1 |
| Keyghobadi, M; McKee, BL; Meshul, CK; Tozier De La Poterie, AP | 1 |
| Pierce, RC; Schmidt, HD | 1 |
| Licata, SC; Renshaw, PF | 1 |
| Chuhma, N; Edwards, RH; Goh, GY; Hnasko, TS; Palmiter, RD; Rayport, S; Sulzer, D; Zhang, H | 1 |
| Chen, J; Freed, WJ; Lee, CT; Worden, LT | 1 |
| Patil, T; Raffa, RB; Rawls, SM; Yuvasheva, E | 1 |
| Gardner, EL; Li, J; Li, X; Xi, ZX | 1 |
| Ecke, LE; Suto, N; Wise, RA; You, ZB | 1 |
| Ardecky, R; Conn, PJ; Cosford, ND; Dahl, R; Jin, X; Markou, A; Semenova, S; Sheffler, DJ; Yang, L | 1 |
| Balado, E; Berson, N; Deroche-Gamonet, V; Kasanetz, F; Lafourcade, M; Manzoni, O; Piazza, PV | 1 |
| Bonci, A; Bowers, MS; Chen, BT | 1 |
| Argyriou, AA; Giannakopoulou, F; Karanasios, P; Makridou, A; Makris, N; Vlachou, M | 1 |
| Bäckman, CM; Chefer, VI; Diaz-Ruiz, O; Good, CH; Hoffman, AF; Kuang, SY; Luo, Y; Lupica, CR; Malik, N; Shan, L; Tomac, AC; Zhang, Y | 1 |
| Lominac, KD; McCreary, AC; McIver, G; Szumlinski, KK; Valdivia, PN; Zayara, AE | 1 |
| Budziszewska, B; Gasior, M; Kaminski, RM; Lasoń, W; Núñez-Taltavull, JF; Shippenberg, TS; Witkin, JM; Zapata, A | 1 |
| Besnard, A; Caboche, J; Girault, JA; Heck, N; Hervé, D; Pagès, C; Pascoli, V; Vanhoutte, P | 1 |
| Alvarez, VA; Bock, R; Christensen, CH; Dobi, A; Seabold, GK | 1 |
| Do, PH; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE | 1 |
| Kash, TL; Nobis, WP; Silberman, Y; Winder, DG | 1 |
| Bellone, C; Brown, MT; Lüscher, C; Mameli, M | 1 |
| Brimson, M; Cayetano, K; Gillis, TE; Jensen, JE; Kaufman, MJ; Liu, X; Prescot, AP; Renshaw, PF; Zuo, CS | 1 |
| Liu, K; Steketee, JD | 2 |
| Bilbao, A; Blanco, E; Campos-Sandoval, JA; de Fonseca, FR; Luque-Rojas, MJ; Márquez, J; Palomino, A; Suárez, J | 1 |
| Guimarães, WV; Norremose, KA; Oliveira, MF; Oliveira, OP; Sekeff, FA | 1 |
| Raffa, RB; Rawls, SM; Song, K; Tallarida, C | 1 |
| Ghasemzadeh, MB; Giles, C; Mantsch, JR; Purgianto, A; Seubert, C; Vasudevan, P | 1 |
| Alonso-Carrión, FJ; Bermúdez-Silva, FJ; Bilbao, A; Blanco, E; Campos-Sandoval, JA; de Fonseca, FR; Estivill-Torrús, G; Gutiérrez, A; Luque-Rojas, MJ; Márquez, J; Palomino, A; Santín, LJ; Suárez, J | 1 |
| Bellone, C; Lüscher, C; Mameli, M | 1 |
| Ambrosio, E; Botreau, F; Coria, SM; Del Olmo, N; Higuera-Matas, A; Miguéns, M; Olías, O | 1 |
| Kalivas, BC; Kalivas, PW; Kolokithas, R; Kupchik, YM; Moussawi, K; Ogburn, KB; Tang, XC; Wang, X | 1 |
| Ben-Shahar, OM; Bernstein, N; Carosso, GA; Cohen, A; DeMartini, J; Gordon, E; Lominac, KD; Nabhan, AN; Pagano, K; Ploense, KL; Rudy, NM; Sacramento, A; Szumlinski, KK; Woodward, N | 1 |
| Aston-Jones, G; Mahler, SV; Smith, RJ | 1 |
| Antonelli, T; Beggiato, S; Ferraro, L; Filip, M; Frankowska, M; Fuxe, K; Marcellino, D; Tanganelli, S; Tomasini, MC; Zaniewska, M | 1 |
| Kiyatkin, EA; Wakabayashi, KT | 2 |
| Kiyatkin, EA; Lenoir, M | 1 |
| Owaisat, S; Raffa, RB; Rawls, SM | 1 |
| Kalivas, PW; Knackstedt, LA; LaLumiere, RT; Reissner, KJ; Trantham-Davidson, H | 1 |
| Baker, DA; Kau, KS; Kong, L; Lutgen, V; Madayag, A; Mantsch, JR | 1 |
| Gabriele, A; Pacchioni, AM; See, RE | 1 |
| Benaliouad, F; Bonci, A; Britt, JP; McDevitt, RA; Stuber, GD; Wise, RA | 1 |
| Chen, L; Wang, L; Ye, JH; Zuo, W | 1 |
| Bollati, F; Cancela, LM; Esparza, MA; Garcia-Keller, C; Kalivas, PW; Martinez, SA | 1 |
| Hsu, KS; Huang, CC; Wu, MY; Yeh, CM | 1 |
| Gipson, CD; Kalivas, PW; Kupchik, YM; Reissner, KJ; Shen, H; Thomas, CA | 1 |
| Ary, AW; Ben-Shahar, O; Campbell, RR; Klugmann, M; Lominac, KD; Szumlinski, KK; von Jonquieres, G; Williams, AR; Wroten, MG | 1 |
| Ortinski, PI; Pierce, RC; Turner, JR | 1 |
| Kaneda, K; Kurosawa, R; Minami, M; Shinohara, F; Taoka, N | 1 |
| Arguello, AA; Fuchs, RA; Reittinger, AM; Wells, AM; Xie, X | 1 |
| Argilli, E; Bonci, A; Madhavan, A; Whistler, JL | 1 |
| Steketee, JD; Timmer, KM | 1 |
| Carson, RE; Grassetti, A; Huang, Y; Kegeles, LS; Lin, SF; Liu, F; Mao, X; Martinez, D; Nabulsi, N; Perez, A; Ropchan, J; Shungu, DC; Slifstein, M; Urban, NB | 1 |
| Barbon, A; Caffino, L; Calabrese, F; Fumagalli, F; Giannotti, G; Racagni, G; Verheij, MM | 1 |
| Chen, YH; Good, CH; Hoffman, AF; Lupica, CR; Mejias-Aponte, CA; Wang, H | 1 |
| Jiao, RY; Kang, XJ; Kuo, ST; Li, ML; Liu, B; Liu, LN; Liu, W; Shang, SJ; Song, MY; Teng, SS; Wang, CH; Wang, SR; Xu, HD; Xu, ZQ; Yang, H; Zhang, B; Zhang, XY; Zhou, L; Zhou, Z; Zhu, FP | 1 |
| Gipson, CD; Huits, M; Kalivas, PW; Shen, HW | 1 |
| Boison, D; Canas, PM; Chen, JF; Cunha, RA; Garcia-Sanz, P; Lan, JQ; Moratalla, R; Shen, HY | 1 |
| Balleine, BW; Chieng, BC; Corbit, LH | 1 |
| Doyle, SE; Garber, G; Lynch, WJ; Newman, J; Ramôa, C; Toor, Z | 1 |
| Bellivier, F; Caboche, J; Cahill, E; Pascoli, V; Vanhoutte, P | 1 |
| Kelley, LK; Naughton, SX; Parikh, V; Rawls, SM; Shi, X; Tallarida, CS; Unterwald, EM; Yegla, B | 1 |
| Filip, M; Fuxe, K; Gołembiowska, K; Kamińska, K; Suder, A; Wydra, K | 1 |
| Buchta, WC; Riegel, AC; Williams, CL | 1 |
| Gipson, CD; Kalivas, PW | 1 |
| Alen, F; Bilbao, A; Blanco, E; Luque-Rojas, MJ; Palomino, A; Pavón, FJ; Rivera, P; Rodríguez de Fonseca, F; Serrano, A; Suárez, J; Vida, M | 1 |
| Andersen, SL; Brenhouse, HC; Sonntag, KC; Thompson, BS | 1 |
| Boger, HA; Haydon, PG; Kalivas, PW; Li, H; Scofield, MD; Smith, RJ | 1 |
| Buendia, MA; Chapman, MA; Durai, HH; Graham, DL; Stanwood, GD | 1 |
| Beaumont, M; Doyle, M; Heshmati, M; Khibnik, LA; Nestler, EJ; Russo, SJ; Slesinger, PA | 1 |
| Cryan, JF; Glennon, J; Moloney, RD; O'Connor, RM; Vlachou, S | 1 |
| Bellivier, F; Besnard, A; Bolte, S; Caboche, J; Crettol, S; Daumas, S; Eap, CB; El Mestikawy, S; Giros, B; Gratton, A; Gutiérrez-Cuesta, J; Heck, N; Henrion, A; Herzog, E; Jamain, S; Lecca, S; Maldonado, R; Mameli, M; Marti, F; Martín-García, E; Moquin, L; Morel, LJ; Prado, MA; Prado, VF; Sakae, DY; Vanhoutte, P; Vorspan, F | 1 |
| Aguiar, DC; Crippa, JA; de Oliveira, AC; Gobira, PH; Gonçalves, BD; Moreira, FA; Santos, RP; Vieira, LB; Vilela, LR | 1 |
| Alvarsson, A; Kadkhodaei, B; Millan, MJ; Perlmann, T; Schintu, N; Stan, TL; Svenningsson, P; Zhang, X | 1 |
| Kippin, TE; Ruppert-Majer, MA; Serchia, MM; Shahin, JR; Shin, CB; Szumlinski, KK | 1 |
| Bourgoin, L; Cathala, A; Deroche-Gamonet, V; Fiancette, JF; Grandes, P; Gutiérrez-Rodriguez, A; Kasanetz, F; Maldonado, R; Marsicano, G; Martín-García, E; Mondesir, M; Piazza, PV; Reguero, L; Spampinato, U | 1 |
| Hill, K; Knackstedt, LA; LaCrosse, AL | 1 |
| Dong, Y | 1 |
| Alen, F; Bilbao, A; Blanco, E; Castilla-Ortega, E; de Fonseca, FR; Decara, J; Galeano, P; Palomino, A; Pavón, FJ; Rivera, P; Rubio, L; Serrano, A; Suárez, J; Vargas, A | 1 |
| Bobadilla, AC; Bollati, F; Brown, RM; Cancela, LM; Esparza, MA; Garcia-Keller, C; Gipson, CD; Heinsbroek, JA; Kalivas, PW; Kupchik, YM; Roberts-Wolfe, DJ; Spencer, S | 1 |
| de Freitas, IG; de Melo Reis, RA; Dos Santos Pereira, M; Kubrusly, RC; Lowe, J; Manhães, AC; Martins, RS; Pecinalli, NR; Santos, LE; Sathler, MF; Stutz, B; Taveira-da-Silva, R | 1 |
| Choi, JY; Finkelstein, J; Lee, J; Witten, IB | 1 |
| Chen, J; Cui, R; Liu, XX; Wang, YC; Zhang, BX | 1 |
| Diana, MA; Mameli, M; Meye, FJ; Schwarz, MK; Smit, T; Soiza-Reilly, M | 1 |
| Baumann, MH; Elmore, JS; Hoffman, AF; Lupica, CR; Wright, AM; Zapata, A | 1 |
| Calipari, ES; Issler, O; Kiraly, DD; Labonte, B; Nestler, EJ; Pena, CJ; Ribeiro, EA; Russo, SJ; Walker, DM | 1 |
| Carlblom, N; Marron Fernandez de Velasco, E; Wickman, K; Xia, Z | 1 |
| Avvisati, R; Badiani, A; Malavasi, E; Marinelli, S; Meringolo, M; Stendardo, E | 1 |
| Althobaiti, YS; Das, SC; Hammad, AM; Sari, Y | 1 |
| Alasmari, F; Althobaiti, YS; Hammad, AM; Sari, Y | 1 |
| Bi, GH; Gao, JT; He, Y; Xi, ZX; Yang, HJ; Zhang, HY | 1 |
| Alcorn, JL; Hays, LR; Levi Bolin, B; Lile, JA; Rayapati, AO; Rush, CR; Stoops, WW | 1 |
| Grycel, K; Jiao, R; Khan, YM; Li, J; Liu, B; Song, R; Sun, X; Wang, L; Wang, Q; Wu, Q; Xu, Y; Zhang, B; Zhou, L; Zhou, Z; Zhu, F | 1 |
| Chiu, AS; Gable, ES; Kim, J; Kippin, TE; Shin, CB; Szumlinski, KK; Templeton, TJ; Vieira, PA | 1 |
| Shin, CB; Szumlinski, KK | 1 |
| Bergman, J; Carlezon, WA; Coyle, JT; Desai, RI; Donahue, RJ; Doyle, MR; Landino, SM; Presti, KT; Puhl, MD; Takagi, S | 1 |
| Scofield, MD | 1 |
| Bi, GH; Gardner, EL; He, Y; Jordan, CJ; Li, J; Li, X; Peng, XQ; Xi, ZX; Yang, HJ; Zhang, HY | 1 |
| Knackstedt, L; Leong, KC; Logan, CN; Peris, J; Reichel, CM; Weber, RA | 1 |
| Knackstedt, LA; LaCrosse, AL; Logan, CN | 1 |
| Broberger, C; Fisone, G; Protzmann, J; Spigolon, G; Stagkourakis, S; Williams, P | 1 |
| Cannazza, G; Cantacorps, L; Cheron, J; De Backer, JF; De Backer, O; de Kerchove d'Exaerde, A; Detraux, B; Faure, P; Gall, D; Gazan, A; Monlezun, S; Nassar, M; Schiffmann, SN; Valverde, O; Valverde, S; Vanopdenbosch, L; Venance, L; Zoli, M | 1 |
| Caffino, L; Fumagalli, F; Guo, C; Homberg, JR; Que, L; Verheij, MMM | 1 |
| Bellone, C; Bimpisidis, Z; Creed, M; Dorst, MC; Dumas, S; Lüscher, C; Papathanou, M; Pettersson, H; Silberberg, G; Wallén-Mackenzie, Å | 1 |
| Bifone, A; Cannella, N; Ciccocioppo, R; Cippitelli, A; Domi, E; Gozzi, A; Li, H; Matzeu, A; Scuppa, G; Ubaldi, M; Weiss, F | 1 |
| Kaneda, K | 1 |
| Kawa, AB; Kennedy, RT; Robinson, TE; Valenta, AC | 1 |
| Bobadilla, AC; Gipson, CD; Heinsbroek, JA; Kalivas, PW; Roberts-Wolfe, DJ; Smith, ACW; Spencer, SM | 1 |
| Filip, M; Mizera, J; Niedzielska-Andres, E; Pomierny-Chamioło, L; Sadakierska-Chudy, A | 1 |
| Briand, LA; McGrath, AG | 1 |
| Brock, AG; Haigh, K; Hooker, KN; McFaddin, JA; McGonegal, LK; Nan Leath, M; Scofield, MD; Siemsen, BM | 1 |
| Jimenez-Rivera, CA; Santos-Vera, B; Vazquez-Torres, R; Velasquez-Martinez, MC; Velez-Hernandez, ME | 1 |
| Assali, A; Bobadilla, AC; Chalhoub, RM; Cowan, CW; Dereschewitz, E; Heinsbroek, JA; Kalivas, PW | 1 |
| Caffino, L; Fumagalli, F; Homberg, JR; Mottarlini, F; Telese, F; Van Reijmersdal, B; Verheij, MMM | 1 |
| Baumgartner, MR; Engeli, EJE; Esposito, F; Henning, A; Herdener, M; Hock, A; Hulka, LM; Kirschner, M; Nordt, C; Quednow, BB; Scheidegger, M; Seifritz, E; Zoelch, N | 1 |
| Buck, SA; Freyberg, Z; Logan, RW; Torregrossa, MM | 1 |
| Caffino, L; Fumagalli, F; Golebiowska, J; Homberg, JR; Mottarlini, F; Nikiforuk, A; Popik, P; Roversi, K; Targa, G; Verheij, MMM | 1 |
| Fowles, K; Groman, SM; Hillmer, AT; Holden, D; Lee, D; Liu, H; Morris, ED; Taylor, JR | 1 |
| Calleti, G; Flores Peres, V; Fraga de Souza, M; Freese, L; Gomez, R; Maria Tannhauser Barros, H; Schüler Nin, M | 1 |
| Avalos, MP; Bollati, FA; Cancela, LM; García-Keller, C; Guzmán, AS; Mongi-Bragato, B | 1 |
| Acher, F; Befort, K; Bourdy, R; De Sa Nogueira, D; Filliol, D; McCort-Tranchepain, I; Quessada, C; Romieu, P; Zwiller, J | 1 |
| Andrade, YCP; Batista, LA; Del Bel, EA; Fanelli, C; Issy, AC; Liégeois, JF; Minaldi, E; Moreira, FA; Rodrigues, LCM; Ropke, J; Viana, TG | 1 |
| Shen, HW; Shi, J; Yu, ZP; Zhang, LY; Zhang, XQ; Zhou, YQ | 1 |
| Ersche, KD; Lim, TV; Murley, AG; Robbins, TW; Rua, C; Vaghi, MM; White, TL; Williams, GB | 1 |
| Neogi, R; Neugornet, A; O'Donovan, B; Ortinski, P; Xia, M | 1 |
| Caffino, L; Fumagalli, F; Homberg, J; Mottarlini, F; Targa, G; Verheij, MMM | 1 |
| Briand, LA; Kirkland, JM; Knouse, MC; McGrath, AG; Wickens, MM | 1 |
| Avalos, MP; Bollati, FA; Cancela, LM; De Giovanni, LN; Euliarte, PV; Guzman, AS; Mongi-Bragato, B; Rigoni, D; Sanchez, MA; Virgolini, MB | 1 |
| Abulseoud, OA; Angebrandt, A; Montemitro, C; Pettorruso, M; Wang, TY | 1 |
| Aggelidou, E; Deda, O; Gika, H; Kritis, A; Krokos, A; Raikos, N; Theodoridis, G; Virgiliou, C | 1 |
| Knackstedt, LA; Logan, CN; Peris, J; Polo Escorcia, AK; Reichel, CM; Rojas, G; Wilkinson, CS | 1 |
| Avalos, MP; Bollati, FA; Calfa, GD; Cancela, LM; Garcia-Keller, C; Gorostiza, EA; Guzman, AS; Iribarren, P; Mongi-Bragato, B; Peralta Ramos, JM; Perassi, EM; Rigoni, D; Sanchez, MA; Virgolini, MB | 1 |
| Bi, GH; Gardner, EL; He, Y; Hempel, BJ; Xi, ZX; Yang, HJ; Zhang, HY | 1 |
| Caffino, L; Fumagalli, F; Homberg, JR; Mottarlini, F; Targa, G; Verheij, MMM | 1 |
| Arizanovska, D; Buie, N; Puranik, A; Steidl, S; Vezina, P | 1 |
| Mao, LM; Mathur, N; Wang, JQ | 1 |
| Addiction, CFSNO; Binh Tran, TD; Bubier, JA; Chesler, EJ; Dickson, PE; Nguyen, H; Philip, VM; Sodergren, E; Weinstock, GM; Wright, SN; Zhou, Y | 1 |
| Catalfio, AM; Ferrario, CR; Fetterly, TL; Nieto, AM; Robinson, TE | 1 |
| Engeli, EJE; Esposito, F; Herdener, M; Hock, A; Hulka, LM; Kirschner, M; Ponticorvo, S; Preller, KH; Quednow, BB; Russo, AG; Seifritz, E; Zoelch, N | 1 |
| Gipson, CD; Hong, M; Khatri, SN; Maher, EE; Sadek, S; Stoops, WW; Ulangkaya, H; Woodcox, AM | 1 |
| Adeyeye, EI; Aluko, AO; Asaolu, SS | 1 |
| Agunbiade, TB; Akinnagbe, NT; Alese, OO; Olaniyi, KS; Oniyide, AA; Sabinari, IW | 1 |
25 review(s) available for cocaine and glutamic acid
| Article | Year |
|---|---|
Pharmacotherapy of cerebral ischemia in cocaine dependence.
Topics: Aspirin; Brain; Brain Ischemia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Intracranial Embolism and Thrombosis; Male; Nerve Degeneration; Neuropsychological Tests; Platelet Aggregation Inhibitors; Radionuclide Imaging; Substance Withdrawal Syndrome | 1998 |
Glutamatergic involvement in psychomotor stimulant action.
Topics: Animals; Brain; Central Nervous System Stimulants; Cocaine; Glutamic Acid; Humans; Motor Activity; Phenethylamines; Psychomotor Performance; Sympathomimetics | 1998 |
Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Methamphetamine; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substantia Nigra | 2001 |
Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cocaine; Dopamine; Glutamic Acid; Models, Molecular; Nucleus Accumbens | 2001 |
The roles of calcium/calmodulin-dependent and Ras/mitogen-activated protein kinases in the development of psychostimulant-induced behavioral sensitization.
Topics: Amphetamine; Animals; Behavior, Addictive; Calcium; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Humans; Mitogen-Activated Protein Kinases; Neuronal Plasticity; ras Proteins; Second Messenger Systems; Synaptic Transmission; Ventral Tegmental Area | 2003 |
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking.
Topics: Basal Ganglia; Cocaine; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Humans; Limbic System; Models, Neurological; Neural Pathways; Recurrence; Synaptic Transmission | 2005 |
Cortical mechanisms of cocaine sensitization.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Prefrontal Cortex; Receptors, Dopamine; Receptors, GABA; Receptors, Glutamate; Synaptic Transmission | 2005 |
Glutamatergic substrates of drug addiction and alcoholism.
Topics: Alcoholism; Amphetamines; Animals; Cannabinoids; Cocaine; Disease Models, Animal; Extinction, Psychological; Glutamic Acid; Humans; Narcotics; Neuronal Plasticity; Nicotine; Substance-Related Disorders; Synapses; Synaptic Transmission | 2008 |
Homers regulate drug-induced neuroplasticity: implications for addiction.
Topics: Animals; Carrier Proteins; Cocaine; Ethanol; Glutamic Acid; Homer Scaffolding Proteins; Humans; Methamphetamine; Neuronal Plasticity; Nucleus Accumbens; Prefrontal Cortex; Schizophrenia; Substance-Related Disorders | 2008 |
Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Glutamic Acid; Humans; Nerve Net; Neuronal Plasticity | 2007 |
Ventral tegmental glutamate: a role in stress-, cue-, and cocaine-induced reinstatement of cocaine-seeking.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Cues; Glutamic Acid; Humans; Stress, Psychological; Ventral Tegmental Area | 2009 |
Glutamate: the new frontier in pharmacotherapy for cocaine addiction.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, Glutamate; Signal Transduction; Synaptic Transmission | 2008 |
Glutamate and reinstatement.
Topics: Animals; Behavior, Addictive; Brain; Cocaine; Ethanol; Glutamic Acid; Heroin; Humans; Nicotine; Receptors, Glutamate; Recurrence; Substance-Related Disorders; Synaptic Transmission | 2009 |
Brain-derived neurotrophic factor and cocaine addiction.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; Humans; MAP Kinase Signaling System; Nucleus Accumbens; Prefrontal Cortex | 2010 |
Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Models, Neurological; Neuronal Plasticity; Nucleus Accumbens; Rats; Receptors, Glutamate; Reinforcement, Psychology; Signal Transduction; Synaptic Transmission | 2010 |
Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction.
Topics: Alcoholism; Animals; Appetite Stimulants; Aspartic Acid; Brain; Choline; Cocaine; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Marijuana Abuse; Neurochemistry; Opiate Alkaloids; Smoking; Substance-Related Disorders; Toluene | 2010 |
AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future.
Topics: Animals; Central Nervous System Stimulants; Clinical Trials as Topic; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Limbic System; Models, Biological; Neuronal Plasticity; Prefrontal Cortex; Receptors, AMPA; Signal Transduction; Synapses; Synaptic Transmission | 2010 |
Extracellular signal-regulated protein kinases 1 and 2 activation by addictive drugs: a signal toward pathological adaptation.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Enzyme Activation; Glutamic Acid; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Signal Transduction | 2014 |
Silent Synapse-Based Circuitry Remodeling in Drug Addiction.
Topics: Adaptation, Physiological; Adaptation, Psychological; Animals; Behavior, Addictive; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Drug Users; Excitatory Postsynaptic Potentials; Glutamic Acid; Humans; Neuronal Plasticity; Nucleus Accumbens; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2016 |
Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Craving; Cues; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Extinction, Psychological; Glutamic Acid; Humans; MAP Kinase Signaling System; Mice; Prefrontal Cortex; Protein Kinase C; Rats; Substance Withdrawal Syndrome; Withholding Treatment | 2018 |
Exploring the Role of Astroglial Glutamate Release and Association With Synapses in Neuronal Function and Behavior.
Topics: Animals; Astrocytes; Calcium Channels, N-Type; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Neuronal Plasticity; Neurons; Nucleus Accumbens; Synapses; Synaptic Transmission | 2018 |
The contribution of neuroplasticity induced in cholinergic neurons of the laterodorsal tegmental nucleus to cocaine addiction.
Topics: Animals; Cholinergic Neurons; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Neuronal Plasticity; Synapses | 2017 |
A potential role for microglia in stress- and drug-induced plasticity in the nucleus accumbens: A mechanism for stress-induced vulnerability to substance use disorder.
Topics: Animals; Cocaine; Glutamic Acid; Humans; Microglia; Neuronal Plasticity; Nucleus Accumbens; Substance-Related Disorders | 2019 |
Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse.
Topics: Analgesics, Opioid; Animals; Biological Transport; Cocaine; Dopamine; Dopaminergic Neurons; Ethanol; Glutamic Acid; Humans; Nerve Net; Nucleus Accumbens; Rodentia; Species Specificity; Substance-Related Disorders; Synaptic Transmission; Synaptic Vesicles; Ventral Tegmental Area | 2021 |
Mechanistic insights into the efficacy of memantine in treating certain drug addictions.
Topics: Animals; Brain; Cocaine; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Neurons; Opiate Alkaloids; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders | 2021 |
1 trial(s) available for cocaine and glutamic acid
| Article | Year |
|---|---|
Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and
Topics: Acetylcysteine; Animals; Cocaine; Glutamic Acid; Humans; Magnetic Resonance Imaging; Proton Magnetic Resonance Spectroscopy | 2023 |
272 other study(ies) available for cocaine and glutamic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Long-lasting abolishment of noradrenaline induced stimulation of oxidative metabolism after chronic exposure of developing mouse astrocytes to cocaine.
Topics: Animals; Animals, Newborn; Astrocytes; Basal Ganglia; Brain; Carbon Dioxide; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Meninges; Mice; Norepinephrine; Olfactory Bulb; Organ Specificity; Oxygen Consumption; Substance-Related Disorders; Time Factors | 1992 |
Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum.
Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Corpus Striatum; Dopamine Agents; Glutamates; Glutamic Acid; Interneurons; Male; Neurons; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1992 |
NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine; Dopamine; Glutamates; Glutamic Acid; Heroin; Male; Microinjections; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reward; Self Administration | 1992 |
An in vitro study on increased neuronal and astrocytic vulnerability to neurotoxic injury after in utero cocaine exposure: the reversal effects of GM1 treatment.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Astrocytes; Biological Transport; Body Water; Cell Size; Cells, Cultured; Cerebral Cortex; Cocaine; Female; Fetal Diseases; G(M1) Ganglioside; Glutamates; Glutamic Acid; Hypoxia; Maternal-Fetal Exchange; Neurons; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley | 1992 |
Effects of systemically and locally applied cocaine on cerebrocortical neuron responsiveness to afferent synaptic inputs and glutamate.
Topics: Amino Acids; Animals; Brain; Cerebral Cortex; Cocaine; Dopamine; Electric Stimulation; Glutamates; Glutamic Acid; Iontophoresis; Male; Neurons, Afferent; Neurotransmitter Agents; Rats; Serotonin; Synapses | 1991 |
Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Caffeine; Cocaine; Dopamine; Glutamates; Glutamic Acid; Heroin; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Effect of cocaine on macromolecular syntheses and cell proliferation in cultured glial cells.
Topics: Animals; Animals, Newborn; Brain Neoplasms; Cell Division; Cells, Cultured; Cocaine; DNA; Glioma; Glutamates; Glutamic Acid; L-Lactate Dehydrogenase; Leucine; Nerve Tissue Proteins; Neuroglia; Rats; Rats, Sprague-Dawley; RNA; Thymidine; Trypan Blue; Tumor Cells, Cultured; Uridine | 1993 |
Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration.
Topics: Animals; Brain; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Glutamic Acid; Iontophoresis; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Self Administration | 1995 |
Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens.
Topics: Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Calcium; Cocaine; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin | 1995 |
Effects of cocaine and the cocaine analog CFT on glutamatergic neurons.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; Male; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
D1 receptors modulate glutamate transmission in the ventral tegmental area.
Topics: Animals; Benzazepines; Cocaine; Dopamine Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Synaptic Transmission; Tegmentum Mesencephali | 1995 |
Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.
Topics: Amphetamine; Animals; Cocaine; Glutamic Acid; Male; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 1995 |
The dopaminergic, glutamatergic, GABAergic bases for the action of amphetamine and cocaine.
Topics: Amphetamine; Animals; Bicuculline; Cocaine; Dopamine Agonists; GABA Agonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Movement; Neostriatum; Piperazines; Stereotyped Behavior; Sulpiride | 1995 |
Cocaine behavioral sensitization and the excitatory amino acids.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Haloperidol; Male; Mice; Neuroeffector Junction; Receptors, GABA-A; Seizures; Stereotyped Behavior | 1994 |
Glutamatergic antagonists attenuate ability of dopamine uptake blockers to increase extracellular levels of dopamine: implications for tonic influence of glutamate on dopamine release.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Chloral Hydrate; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Microdialysis; Nomifensine; Rats | 1994 |
Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists.
Topics: Amino Acids; Animals; Cocaine; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Male; Methamphetamine; Mice; Motor Activity; Pyrrolidinones; Quinoxalines | 1993 |
Concurrent reflectance imaging and microdialysis in the freely behaving cat.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Cats; Cell Size; Chromatography, High Pressure Liquid; Cocaine; Diagnostic Imaging; Electroencephalography; Fiber Optic Technology; Glutamic Acid; Microdialysis; Narcotics; Neurons; Osmolar Concentration; Videotape Recording | 1996 |
Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release.
Topics: Analysis of Variance; Animals; Calcium; Cocaine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Stimulation, Chemical | 1996 |
Chronic cocaine enhances gamma-aminobutyric acid and glutamate release by altering presynaptic and not postsynaptic gamma-aminobutyric acidB receptors within the rat dorsolateral septal nucleus.
Topics: Animals; Bicuculline; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Septal Nuclei; Synaptic Transmission | 1997 |
Extracellular aspartate concentration increases in nucleus accumbens after cocaine sensitization.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cocaine; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1997 |
Dopaminergic and glutamatergic mechanisms mediate the induction of FOS-like protein by cocaethylene.
Topics: Analgesics; Animals; Benzazepines; Brain; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Female; Glutamic Acid; Kinetics; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors.
Topics: Amphetamine; Animals; Cocaine; Dopamine; Glutamic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Ventral Tegmental Area | 1997 |
Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine.
Topics: Amphetamine; Animals; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Glutamic Acid; Limbic System; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1997 |
Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Ibotenic Acid; Male; Microdialysis; Motor Activity; Narcotics; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Thalamus | 1998 |
Repeated cocaine administration alters extracellular glutamate in the ventral tegmental area.
Topics: Animals; Cocaine; Drug Administration Schedule; Extracellular Space; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1998 |
Teaching the brain to take drugs.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Rats; Receptors, Glutamate; Substance-Related Disorders; Synaptic Transmission; Taurine | 1998 |
DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.
Topics: Amphetamines; Animals; Behavior, Animal; Calcium; Cocaine; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agents; Dopamine and cAMP-Regulated Phosphoprotein 32; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Gene Targeting; Genes, fos; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Raclopride; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Salicylamides; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 1998 |
Cocaine-induced changes in glutamate and GABA immunolabeling within rat habenula and nucleus accumbens.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Female; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Immunohistochemistry; Microscopy, Electron; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 1998 |
Decreased presynaptic sensitivity to adenosine after cocaine withdrawal.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Affinity Labels; Animals; Cocaine; Dipyridamole; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Nucleus Accumbens; Phosphodiesterase Inhibitors; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Thioinosine; Vasodilator Agents; Xanthines | 1998 |
Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Synaptic Vesicles; Time Factors | 1998 |
Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment.
Topics: Adaptation, Physiological; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Uptake Inhibitors; Gene Expression; Glutamic Acid; Male; Molecular Sequence Data; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Ventral Tegmental Area | 1999 |
Behavioral effects of cocaine on a transgenic mouse model of cortical-limbic compulsion.
Topics: Animals; Cerebral Cortex; Cholera Toxin; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Female; Gene Expression; Glutamic Acid; Humans; Limbic System; Mice; Mice, Inbred BALB C; Mice, Transgenic; Obsessive-Compulsive Disorder; Receptors, Dopamine D1; Stereotyped Behavior; Transgenes | 1999 |
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Benzazepines; Cocaine; Cocaine-Related Disorders; Dizocilpine Maleate; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamates; Glutamic Acid; Male; Nucleus Accumbens; Procaine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Synaptic Transmission | 1999 |
Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics.
Topics: Anesthetics, Local; Animals; Carrier Proteins; Cocaine; COS Cells; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; HeLa Cells; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Procaine; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 2000 |
Toward development of an in vitro model of methamphetamine-induced dopamine nerve terminal toxicity.
Topics: Animals; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fenfluramine; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Methamphetamine; Neostriatum; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Temperature; Time Factors | 2000 |
Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Synaptic Transmission | 2000 |
Context-specific enhancement of glutamate transmission by cocaine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Chemistry; Cocaine; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Male; Microdialysis; Microinjections; Neurotransmitter Agents; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stimulation, Chemical; Synaptic Transmission | 2000 |
Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats.
Topics: Animals; Cocaine; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred F344; Self Administration; Serotonin | 2000 |
Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression.
Topics: Amygdala; Analysis of Variance; Anesthetics, Local; Animals; Basal Ganglia; Cocaine; Dopamine; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; Nucleus Accumbens; Oncogene Proteins v-fos; Rats; Self Administration; Serotonin; Social Isolation | 2000 |
Effects of intravenous cocaine administration on cerebellar Purkinje cell activity.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Cerebellum; Cocaine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Procaine; Propranolol; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reserpine; Yohimbine | 2000 |
Relapse to cocaine-seeking after hippocampal theta burst stimulation.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electric Stimulation; Electrodes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Hippocampus; Injections, Intravenous; Kynurenic Acid; Medial Forebrain Bundle; Memory; N-Methylaspartate; Rats; Rats, Long-Evans; Recurrence; Reward; Self Administration; Synaptic Transmission; Theta Rhythm; Ventral Tegmental Area | 2001 |
Drug addiction. Zapping memory center triggers drug craving.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electric Stimulation; Extinction, Psychological; Glutamic Acid; Hippocampus; Injections, Intravenous; Medial Forebrain Bundle; Memory; Rats; Recurrence; Reward; Self Administration; Ventral Tegmental Area | 2001 |
Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites.
Topics: Animals; Binding Sites; Carrier Proteins; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutamic Acid; Histidine; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Engineering; Protein Structure, Tertiary; Structure-Activity Relationship; Zinc | 2001 |
Neurobiology. Total recall-the memory of addiction.
Topics: Animals; Brain; Calcium; Calcium Signaling; Cocaine; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Hippocampus; Long-Term Potentiation; Memory; Neurons; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Ventral Tegmental Area | 2001 |
The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Motor Activity; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2001 |
Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia.
Topics: Adult; Aged; Aging; Autoradiography; Basal Ganglia; Caudate Nucleus; Cause of Death; Cocaine; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Female; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Nucleus Accumbens; Putamen; Radioligand Assay; Receptors, N-Methyl-D-Aspartate | 2001 |
Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Cocaine; Corpus Striatum; COS Cells; Cyclin-Dependent Kinases; Cyclins; Dopamine; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Male; Mice; Molecular Sequence Data; Parkinson Disease; PC12 Cells; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA Polymerase II; Transfection | 2001 |
Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.
Topics: Animals; Brain Chemistry; Calcium Channel Blockers; Carrier Proteins; Cocaine; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Homer Scaffolding Proteins; Male; Microdialysis; Motor Activity; Neuropeptides; Nucleus Accumbens; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin | 2001 |
Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Up-Regulation | 2001 |
Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Microinjections; Neostriatum; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recurrence; Reinforcement, Psychology; Septum of Brain; Synaptic Transmission | 2002 |
Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Cell Line; Cocaine; Conserved Sequence; COS Cells; Desipramine; Dopamine Agents; Female; Fluoxetine; Gene Expression; Glutamic Acid; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ovary; Sequence Homology, Amino Acid; Sodium; Structure-Activity Relationship; Symporters; Transfection | 2002 |
Effects of cocaine administration on VTA cell activity in response to prefrontal cortex stimulation.
Topics: Animals; Cocaine; Electric Stimulation; Glutamic Acid; Injections, Intravenous; Male; Neurons; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2002 |
Regulation of medial prefrontal cortex dopamine by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamine; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Neostriatum; Neurons; Potassium Chloride; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Reward; Stress, Physiological; Synaptic Transmission; Up-Regulation | 2002 |
Effect of glutamatergic systems on in vivo binding of [(125)I]beta-CIT in the brain of a rat model of Parkinson's disease.
Topics: Animals; Autoradiography; Binding, Competitive; Cocaine; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Iodine Radioisotopes; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Serotonin; Sympatholytics | 2002 |
Shifts in striatal responsivity evoked by chronic stimulation of dopamine and glutamate systems.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Glutamic Acid; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Glutamate; Signal Transduction; Stereotyped Behavior | 2002 |
Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Cocaine; Cystine; Diltiazem; Dopamine Uptake Inhibitors; Glutamic Acid; Microdialysis; Nucleus Accumbens; omega-Conotoxins; Rats; Tetrodotoxin | 2002 |
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.
Topics: Animals; Blotting, Western; Brain; Cocaine; Cystine; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Phosphorylation; Potassium; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfur Radioisotopes | 2002 |
Alterations in nerve terminal glutamate immunoreactivity in the nucleus accumbens and ventral tegmental area following single and repeated doses of cocaine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Motor Activity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Ultrasonography; Ventral Tegmental Area | 2003 |
Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related Disorders; Cues; Environment; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 2003 |
Extracellular glutamate levels in prefrontal cortex during the expression of associative responses to cocaine related stimuli.
Topics: Acoustic Stimulation; Animals; Cocaine; Conditioning, Psychological; Extracellular Space; Glutamic Acid; Male; Motor Activity; Photic Stimulation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2002 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reward; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.
Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Drug Administration Schedule; Extracellular Space; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Nucleus Accumbens; Phosphorylation; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine; Extinction, Psychological; Extracellular Space; GABA Agonists; Glutamic Acid; Male; Microdialysis; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration | 2003 |
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2003 |
Iptkalim inhibits cocaine challenge-induced enhancement of dopamine levels in nucleus accumbens and striatum of rats by up-regulating Kir6.1 and Kir6.2 mRNA expression.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Glutamic Acid; Male; Nucleus Accumbens; Potassium Channels, Inwardly Rectifying; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2003 |
Discrete cell gene profiling of ventral tegmental dopamine neurons after acute and chronic cocaine self-administration.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Gene Expression Profiling; Glutamic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Self Administration; Ventral Tegmental Area | 2003 |
Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.
Topics: Alanine; Aspartic Acid; Biological Transport; Biotinylation; Blotting, Western; Cell Line; Cell Membrane; Cocaine; Cystine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Mutation; Nerve Tissue Proteins; Phenotype; Piperazines; Protein Binding; Protein Conformation; Protein Transport; Sodium; Time Factors; Zinc | 2004 |
Nerve terminal glutamate immunoreactivity in the rat nucleus accumbens and ventral tegmental area after a short withdrawal from cocaine.
Topics: Animals; Cocaine; Glutamic Acid; Immunochemistry; Male; Motor Activity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2004 |
Brain excitatory amino acid transporters (EAATs) and treatment of methamphetamine toxicity.
Topics: Amino Acid Transport System X-AG; Animals; Anxiety; Biological Transport; Brain; Cocaine; Dicarboxylic Acids; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Male; Methamphetamine; Mice; Mice, Inbred ICR; Motor Activity; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Stereotyped Behavior; Stress, Physiological | 2003 |
Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior.
Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Antagonists; Efferent Pathways; Electroshock; GABA Agonists; Globus Pallidus; Glutamic Acid; Limbic System; Male; Microinjections; Motor Activity; Neostriatum; Neural Inhibition; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Septal Nuclei; Ventral Tegmental Area | 2004 |
Dissociable roles for the dorsal and median raphé in the facilitatory effect of 5-HT1A receptor stimulation upon cocaine-induced locomotion and sensitization.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Extracellular Space; Glutamic Acid; Male; Microdialysis; Microinjections; Motor Activity; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists | 2004 |
Cocaine-induced Fos expression in rat striatum is blocked by chloral hydrate or urethane.
Topics: Amino Acid Transport System X-AG; Animals; Chloral Hydrate; Cocaine; Corpus Striatum; Dicarboxylic Acids; Dopamine; Drug Interactions; Excitatory Amino Acid Agonists; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Neurons; Neurotransmitter Uptake Inhibitors; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Urethane | 2004 |
Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels.
Topics: Animals; Cocaine; Dopamine; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Ventral Tegmental Area | 2004 |
Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine system.
Topics: Animals; Baclofen; Behavior, Animal; Cocaine; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Synergism; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Receptors, GABA-B; Synaptic Transmission; Ventral Tegmental Area | 2004 |
Homer proteins regulate sensitivity to cocaine.
Topics: Animals; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-Response Relationship, Drug; Glutamic Acid; Homer Scaffolding Proteins; Locomotion; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nucleus Accumbens; Self Administration | 2004 |
Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Male; Microdialysis; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.
Topics: Animals; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; Glutamic Acid; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2005 |
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Amino Acid Transport System X-AG; Animals; Biological Clocks; Cell Cycle Proteins; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Mice; Nuclear Proteins; Period Circadian Proteins; Taurine; Time Factors; Transcription Factors | 2005 |
Clock reset for alcoholism.
Topics: Alcohol Drinking; Alcoholism; Animals; Biological Clocks; Cell Cycle Proteins; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Mice; Nuclear Proteins; Period Circadian Proteins; Transcription Factors | 2005 |
Cross-sensitization to morphine in cocaine-sensitized rats: behavioral assessments correlate with enhanced responding of ventral pallidal neurons to morphine and glutamate, with diminished effects of GABA.
Topics: Action Potentials; Animals; Behavior, Animal; Cocaine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Morphine; Motor Activity; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2005 |
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine; Glutamic Acid; Locomotion; Mice; Mice, Knockout; Motor Skills; Nucleus Accumbens; Receptors, Metabotropic Glutamate; Time Factors | 2005 |
Time-dependent changes in extracellular glutamate in the rat dorsolateral striatum following a single cocaine injection.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Immunoelectron; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Acute NMDA receptor antagonism induces biphasic striatal utilization of L-[beta-11C]DOPA: PET studies in the conscious monkey brain.
Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Cocaine; Consciousness; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Macaca mulatta; Male; Neural Pathways; Positron-Emission Tomography; Presynaptic Terminals; Raclopride; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.
Topics: Amino Acids; Animals; Biological Transport; Cocaine; Cocaine-Related Disorders; Consummatory Behavior; Cystine; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Neural Conduction; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Self Administration; Xanthenes | 2005 |
Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference.
Topics: Amino Acid Substitution; Amphetamine; Animals; Brain; Central Nervous System Stimulants; Chromosomes, Artificial, P1 Bacteriophage; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Dopamine; Exploratory Behavior; Glutamic Acid; Locomotion; Mice; Mutation, Missense; Neurons; Point Mutation; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Reward | 2005 |
Homer isoforms differentially regulate cocaine-induced neuroplasticity.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine; Gene Expression Regulation; Glutamic Acid; Homer Scaffolding Proteins; Male; Mice; Microdialysis; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Protein Isoforms; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Time Factors | 2006 |
Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell.
Topics: Animals; Behavior, Animal; Cocaine; Colforsin; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Self Administration; Time Factors | 2006 |
Different patterns of pharmacological reinstatement of cocaine-seeking behavior between Fischer 344 and Lewis rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Extinction, Psychological; Glutamic Acid; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Self Administration; Species Specificity | 2006 |
AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Learning; Male; Mice; Mice, Knockout; Reaction Time; Receptors, AMPA; Reinforcement, Psychology; Reward; Self Administration; Synaptic Transmission | 2007 |
Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electroencephalography; Evoked Potentials; Feedback; Glutamic Acid; Male; Motivation; Nerve Net; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2005 |
Dopamine uptake and cocaine binding mechanisms: the involvement of charged amino acids from the transmembrane domains of the human dopamine transporter.
Topics: Alanine; Amino Acid Substitution; Animals; Arginine; Binding Sites; Binding, Competitive; Chlorocebus aethiops; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kinetics; Lysine; Mutation; Transfection; Tritium | 2006 |
Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors.
Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Glutamic Acid; Male; Neurons; Nucleus Accumbens; Ondansetron; Pergolide; Phosphorylation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serotonin Antagonists; Synaptic Transmission | 2007 |
Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice.
Topics: Animals; Aquaporin 4; Brain; Cocaine; Depression, Chemical; Dopamine; Extracellular Space; Glutamic Acid; Mice; Mice, Knockout; Microdialysis; Motor Activity; Synaptic Transmission | 2006 |
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Recurrence; Reward | 2006 |
Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA.
Topics: Amygdala; Animals; Cocaine; Corticotropin-Releasing Hormone; Cyclic AMP-Dependent Protein Kinases; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, N-Methyl-D-Aspartate; Synapses | 2006 |
Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity.
Topics: Amino Acid Transport System y+; Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Gene Expression Regulation; Glutamic Acid; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration; NF-E2-Related Factor 2; Nucleus Accumbens; Oxidative Stress; Regulatory Elements, Transcriptional | 2007 |
Modulation of D2R-NR2B interactions in response to cocaine.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Central Nervous System Stimulants; Cloning, Molecular; Cocaine; DNA, Complementary; Dopamine Uptake Inhibitors; Electrophysiology; Glutamic Acid; Immunoprecipitation; Locomotion; Male; Neostriatum; Nerve Tissue Proteins; Patch-Clamp Techniques; Phosphorylation; Protein Binding; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 2006 |
Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission.
Topics: Actins; Analysis of Variance; Animals; Apomorphine; Cocaine; Dextroamphetamine; Dopamine; Dopamine Agents; Excitatory Amino Acid Transporter 3; Exploratory Behavior; Fibroblast Growth Factor 2; Frontal Lobe; Glutamic Acid; Hyperkinesis; Mice; Mice, Knockout; Motor Activity; Neostriatum; Nerve Fibers; Neural Pathways; Presynaptic Terminals; RNA, Messenger; Synaptic Transmission; Vesicular Glutamate Transport Protein 1 | 2007 |
Changes in levels of D1, D2, or NMDA receptors during withdrawal from brief or extended daily access to IV cocaine.
Topics: Adaptation, Physiological; Animals; Binding, Competitive; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Injections, Intravenous; Male; Neural Pathways; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 2007 |
Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Glutamic Acid; Isoquinolines; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration | 2007 |
Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats.
Topics: Animals; Biomarkers; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Exploratory Behavior; Glutamic Acid; Limbic System; Male; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Up-Regulation | 2007 |
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.
Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Evoked Potentials, Motor; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Motor Cortex; Neural Inhibition; Substance Withdrawal Syndrome; Synaptic Transmission; Transcranial Magnetic Stimulation | 2007 |
Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses | 2007 |
Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function.
Topics: Acetylcholine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Atropine; Calcium; Cell Differentiation; Cells, Cultured; Cholinergic Agents; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Embryonic Stem Cells; Fluorescent Dyes; Glutamic Acid; Haloperidol; Mice; Microtubule-Associated Proteins; Muscarinic Antagonists; Neurons; Norepinephrine; Phenotype; Tetrodotoxin; Tritium; Tyrosine 3-Monooxygenase | 2007 |
Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat.
Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corticotropin-Releasing Hormone; Dopamine; Electroshock; Glutamic Acid; Male; Protein Binding; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Recurrence; Self Administration; Stress, Psychological; Ventral Tegmental Area | 2007 |
When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence | 2007 |
Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception.
Topics: Animals; Biological Clocks; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Habituation, Psychophysiologic; Ketamine; Learning; Male; Nerve Net; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Perception | 2007 |
Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area.
Topics: Action Potentials; Animals; Cell Shape; Cocaine; Cocaine-Related Disorders; Dendritic Spines; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Long-Term Potentiation; Lysine; Male; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Synapses; Synaptic Transmission; Ventral Tegmental Area | 2007 |
Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice.
Topics: Analgesia; Animals; Behavior, Addictive; Carrier Proteins; Cocaine; Crosses, Genetic; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Heterozygote; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Locomotion; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nucleus Accumbens | 2007 |
Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation.
Topics: Animals; Blotting, Western; Brain Chemistry; Caudate Nucleus; Cocaine; Data Interpretation, Statistical; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Putamen; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2007 |
A role for conditioned ventral tegmental glutamate release in cocaine seeking.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Long-Evans; Reinforcement, Psychology; Ventral Tegmental Area | 2007 |
Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: a time course microdialysis study.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Extracellular Fluid; Female; Glutamic Acid; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred Lew; Self Administration; Time Factors | 2008 |
Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders.
Topics: Adrenergic alpha-Agonists; Animals; Brain Chemistry; Calcium Channels, L-Type; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Glutamic Acid; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mood Disorders; Neural Pathways; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Culture Techniques; Patch-Clamp Techniques; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Glutamate; Septal Nuclei; Synaptic Transmission | 2008 |
A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cocaine; Corpus Striatum; Cytoskeleton; Dopamine Uptake Inhibitors; Embryo, Mammalian; Enzyme Inhibitors; ets-Domain Protein Elk-1; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neurons; Peptides; Phosphorylation; Protein Transport; Serine; Subcellular Fractions; Transfection | 2007 |
Effects of adolescent exposure to cocaine on locomotor activity and extracellular dopamine and glutamate levels in nucleus accumbens of DBA/2J mice.
Topics: Age Factors; Animals; Animals, Newborn; Area Under Curve; Behavior, Animal; Cocaine; Dialysis; Dopamine; Dopamine Uptake Inhibitors; Extracellular Fluid; Glutamic Acid; Male; Mice; Mice, Inbred DBA; Motor Activity; Nucleus Accumbens | 2008 |
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Cocaine-Related Disorders; Diltiazem; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Nucleus Accumbens; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Synaptic Transmission; Threonine | 2008 |
Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice.
Topics: Age Factors; Amino Acids; Animals; Behavior, Addictive; Catecholamines; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Female; Glutamic Acid; Locomotion; Male; Mice; Mice, Inbred C57BL; Narcotics; Neurotransmitter Agents; Nucleus Accumbens; Phenotype; Phenylpropanolamine; Sympathomimetics | 2008 |
The rate of intravenous cocaine administration alters c-fos mRNA expression and the temporal dynamics of dopamine, but not glutamate, overflow in the striatum.
Topics: Animals; Biomarkers; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Extracellular Fluid; Gene Expression; Genes, Immediate-Early; Glutamic Acid; Injections, Intravenous; Microdialysis; Proto-Oncogene Proteins c-fos; Rats; RNA, Messenger; Time Factors; Up-Regulation | 2008 |
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA.
Topics: Animals; Basal Ganglia; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA Agonists; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Microdialysis; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission | 2008 |
The rate of intravenous cocaine or amphetamine delivery does not influence drug-taking and drug-seeking behavior in rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Body Temperature; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; Genes, fos; Glutamic Acid; Infusions, Intravenous; Male; Motor Activity; Neostriatum; Rats; Rats, Long-Evans; Reinforcement Schedule; Self Administration; Substance Abuse, Intravenous | 2008 |
Repeated cocaine administration increases N-methyl-d-aspartate NR1 subunit, extracellular signal-regulated kinase and cyclic AMP response element-binding protein phosphorylation and glutamate release in the rat dorsal striatum.
Topics: Animals; Cocaine; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Male; Phosphorylation; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 2008 |
Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking.
Topics: Animals; Antiporters; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cystine; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Synapses | 2008 |
Effects of chronic buprenorphine treatment on levels of nucleus accumbens glutamate and on the expression of cocaine-induced behavioral sensitization in rats.
Topics: Animals; Brain Mapping; Buprenorphine; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Microdialysis; Motor Activity; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans | 2008 |
Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptors.
Topics: Amino Acids; Animals; Cocaine; Cocaine-Related Disorders; Cystine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Glutamic Acid; Limbic System; Male; Neural Pathways; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission; Synaptic Vesicles; Ventral Tegmental Area; Xanthenes | 2008 |
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release.
Topics: Animals; Cocaine; Dopamine; Drug Implants; Extinction, Psychological; Glutamic Acid; Infusions, Intravenous; Jugular Veins; Male; Microdialysis; Rats; Rats, Long-Evans; Self Administration | 2008 |
Neuronal pentraxins modulate cocaine-induced neuroadaptations.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; C-Reactive Protein; Cocaine; Conditioning, Psychological; Crosses, Genetic; Extracellular Matrix; Gene Deletion; Glutamic Acid; Glycine; Locomotion; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Neurons; Receptors, AMPA; Resorcinols; Synapses | 2009 |
Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling.
Topics: Animals; Carrier Proteins; Cerebral Cortex; Cocaine; Dopamine; Genes, Immediate-Early; Glutamic Acid; Homer Scaffolding Proteins; Limbic System; Male; Nerve Net; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription, Genetic | 2009 |
Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Substance Withdrawal Syndrome; Synaptic Transmission | 2008 |
Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine.
Topics: Action Potentials; Amino Acid Transport System X-AG; Anesthetics, Local; Animals; Cocaine; Computer Simulation; Cystine; Extracellular Fluid; Glutamic Acid; Models, Biological; Neuroglia; Neurons; Nucleus Accumbens; Rats; Receptors, Glutamate; Synapses; Synaptic Transmission | 2009 |
Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
Topics: Amygdala; Animals; Cocaine; Corticotropin-Releasing Hormone; Dopamine; Excitatory Postsynaptic Potentials; Glutamic Acid; Illicit Drugs; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Organ Culture Techniques; Patch-Clamp Techniques; Receptors, Corticotropin-Releasing Hormone; Receptors, Dopamine D1; Receptors, Dopamine D2; Septal Nuclei; Synaptic Transmission | 2008 |
Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration.
Topics: Actins; Adaptation, Physiological; Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Disks Large Homolog 4 Protein; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Homer Scaffolding Proteins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Neuronal Plasticity; Nucleus Accumbens; Presynaptic Terminals; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Synaptic Transmission; Synaptosomes | 2009 |
Cocaine challenge enhances release of neuroprotective amino acid taurine in the striatum of chronic cocaine treated rats: a microdialysis study.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Glutamic Acid; Humans; Male; Microdialysis; Neuroprotective Agents; Rats; Synapses; Taurine | 2009 |
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Excitatory Postsynaptic Potentials; Glutamic Acid; GTP-Binding Proteins; Male; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission | 2009 |
Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network.
Topics: Animals; Cocaine; Dopamine; Drug Interactions; Electroshock; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Kynurenic Acid; Male; Neuropeptides; Orexin Receptors; Orexins; Phenylurea Compounds; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Receptors, G-Protein-Coupled; Receptors, Kainic Acid; Receptors, Neuropeptide; Self Administration; Ventral Tegmental Area | 2009 |
A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Self Administration; Synaptic Transmission | 2009 |
Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbens.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Olfactory Pathways; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration | 2009 |
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Organ Culture Techniques; Receptors, Metabotropic Glutamate; Recurrence; Substance Withdrawal Syndrome; Synaptic Transmission; Ventral Tegmental Area | 2009 |
Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats.
Topics: Anesthetics, Inhalation; Animals; Body Weight; Cocaine; Estrous Cycle; Female; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Sex Factors; Stereotyped Behavior | 2009 |
Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Classical; Conditioning, Operant; Cyclic AMP Response Element-Binding Protein; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Homeodomain Proteins; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Motor Activity; Mutation; Parvalbumins; Pyramidal Cells; Self Administration; Spatial Behavior; Swimming; Telencephalon; Transcription Factors | 2010 |
Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking.
Topics: Analysis of Variance; Animals; Antioxidants; Ceftriaxone; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cystine; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Time Factors; Tritium | 2010 |
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.
Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Extinction, Psychological; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Microdialysis; Microinjections; Neuroprotective Agents; Nucleus Accumbens; Organophosphorus Compounds; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Self Administration; Sucrose; Sweetening Agents | 2010 |
Lesion of the ventromedial nucleus of the thalamus blocks acute cocaine-induced changes in striatal glutamate.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine Uptake Inhibitors; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Neural Pathways; Neurosurgical Procedures; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Ventral Thalamic Nuclei | 2010 |
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Animals, Newborn; Catecholamines; Cell Line, Transformed; Chlorides; Choline; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Luminescent Proteins; Membrane Potentials; Mice; Mice, Transgenic; Motor Activity; Neurons; Presynaptic Terminals; Rats; Serotonin; Synaptic Vesicles; Transfection; Tyrosine 3-Monooxygenase; Vesicular Glutamate Transport Protein 2 | 2010 |
Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex.
Topics: Animals; Cell Movement; Cerebral Cortex; Cocaine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley | 2011 |
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypnotics and Sedatives; Methamphetamine; Motor Activity; Muscarinic Antagonists; Planarians; Scopolamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 2010 |
Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats.
Topics: Animals; Behavior, Addictive; Benzhydryl Compounds; Cocaine; Dose-Response Relationship, Drug; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Self Administration | 2010 |
Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration.
Topics: Animals; Cocaine; Conditioning, Operant; Dopamine; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Long-Evans; Self Administration | 2010 |
The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.
Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Biphenyl Compounds; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Cocaine; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Extinction, Psychological; Feeding Behavior; Glutamic Acid; Humans; Indans; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Reward; Self Administration; Time Factors | 2010 |
Transition to addiction is associated with a persistent impairment in synaptic plasticity.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Glutamic Acid; Long-Term Synaptic Depression; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Self Administration; Synaptic Transmission | 2010 |
Cocaine use and abuse triggering sporadic young-onset amyotrophic lateral sclerosis.
Topics: Adult; Age of Onset; Amyotrophic Lateral Sclerosis; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Male; Motor Neurons; Nerve Degeneration; Receptors, Glutamate | 2011 |
NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Knockout Techniques; Glutamic Acid; Integrases; Mice; Motor Activity; Neurons; Nucleus Accumbens; Olfactory Bulb; Receptors, N-Methyl-D-Aspartate; Recombination, Genetic; Signal Transduction; Synapses; Ventral Tegmental Area | 2010 |
Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats.
Topics: Aminopyridines; Animals; Behavior, Animal; Cocaine; Dopamine; Dose-Response Relationship, Drug; Fluorobenzenes; Glutamic Acid; Indoles; Male; Microdialysis; Neuronal Plasticity; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists | 2011 |
Effects of cocaine-kindling on the expression of NMDA receptors and glutamate levels in mouse brain.
Topics: Animals; Brain; Cocaine; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Kindling, Neurologic; Male; Mice; Microdialysis; Receptors, N-Methyl-D-Aspartate | 2011 |
Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation.
Topics: Animals; Calcium; Cocaine; Conditioning, Psychological; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Mice; Motor Activity; Neurons; Phenols; Phosphorylation; Piperidines; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; src-Family Kinases; Tyrosine | 2011 |
Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal.
Topics: Animals; Cocaine; Dendritic Spines; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Green Fluorescent Proteins; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Transgenic; Motor Activity; Neuronal Plasticity; Neuropsychological Tests; Nucleus Accumbens; Random Allocation; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors | 2011 |
Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.
Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2011 |
β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
Topics: Animals; Cocaine; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Receptors, Adrenergic, beta; Receptors, Corticotropin-Releasing Hormone; Septal Nuclei; Synaptic Transmission | 2011 |
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Glutamic Acid; Mice; Neuronal Plasticity; Organ Culture Techniques; Synaptic Transmission; Ventral Tegmental Area | 2011 |
Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys.
Topics: Analysis of Variance; Animals; Cocaine; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Intramuscular; Magnetic Resonance Spectroscopy; Male; Putamen; Saimiri; Time Factors | 2011 |
Repeated exposure to cocaine alters medial prefrontal cortex dopamine D₂-like receptor modulation of glutamate and dopamine neurotransmission within the mesocorticolimbic system.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Glutamic Acid; Limbic System; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Pyramidal Cells; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spectrometry, Fluorescence; Synaptic Transmission; Ventral Tegmental Area | 2011 |
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice.
Topics: Animals; Blotting, Western; Brain; Cocaine; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutaminase; Isoenzymes; Male; Mice; Mice, Inbred C57BL; RNA, Messenger | 2012 |
Glutamatergic excitotoxicity secondary to status epilepticus after crack abuse: a case report.
Topics: Brain; Crack Cocaine; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Middle Aged; Status Epilepticus | 2011 |
Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
Topics: Animals; Cocaine; Glutamate Carboxypeptidase II; Glutamic Acid; Models, Animal; N-Methylaspartate; Organophosphorus Compounds; Pilocarpine; Planarians; Stereotyped Behavior | 2012 |
Glutamatergic plasticity in medial prefrontal cortex and ventral tegmental area following extended-access cocaine self-administration.
Topics: Animals; Cocaine; Glutamic Acid; Male; Neuronal Plasticity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Self Administration; Time Factors; Ventral Tegmental Area | 2011 |
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Gene Expression Regulation; Glutamic Acid; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Receptors, Glutamate; Receptors, Lysophosphatidic Acid | 2012 |
In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA.
Topics: Age Factors; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; Calcium; Calcium Channel Blockers; Chelating Agents; Cocaine; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Estrenes; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nicotinic Antagonists; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Polyamines; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidinones; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Time Factors; Ventral Tegmental Area | 2011 |
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophoresis, Capillary; Extinction, Psychological; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred F344; Rats, Inbred Lew; Recurrence; Self Administration; Sodium Chloride; Species Specificity | 2013 |
The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
Topics: Acetylcysteine; Animals; Cocaine; Cystine; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Free Radical Scavengers; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recurrence; Synaptic Transmission | 2012 |
Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration | 2012 |
Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoxazoles; Cocaine; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide; Self Administration; Signal Transduction; Urea; Ventral Tegmental Area | 2013 |
A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Locomotion; Male; Microinjections; Nucleus Accumbens; Piperazines; Quinpirole; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D2 | 2012 |
Rapid changes in extracellular glutamate induced by natural arousing stimuli and intravenous cocaine in the nucleus accumbens shell and core.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Cocaine; Dopamine Uptake Inhibitors; Electrochemistry; Extracellular Fluid; Glutamic Acid; Infusions, Intravenous; Interpersonal Relations; Locomotion; Male; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Long-Evans; Self Administration; Wakefulness | 2012 |
Rapid fluctuations in extracellular brain glucose levels induced by natural arousing stimuli and intravenous cocaine: fueling the brain during neural activation.
Topics: Administration, Intravenous; Animals; Arousal; Brain; Cocaine; Extracellular Space; Glucose; Glutamic Acid; Male; Neurons; Nucleus Accumbens; Procaine; Rats; Rats, Long-Evans; Social Environment; Substantia Nigra; Touch | 2012 |
In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
Topics: Amphetamines; Animals; Cocaine; Excitatory Amino Acid Antagonists; Glutamic Acid; Harmine; Inhibition, Psychological; Kainic Acid; Nicotine; Nicotinic Antagonists; Planarians; Psychotropic Drugs | 2012 |
Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training.
Topics: Animals; Ceftriaxone; Cocaine; Extinction, Psychological; Glutamic Acid; Male; Nucleus Accumbens; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Self Administration; Synaptic Transmission | 2012 |
Time course of cocaine-induced behavioral and neurochemical plasticity.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Glutamic Acid; Male; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2014 |
Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.
Topics: Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2012 |
Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens.
Topics: Analysis of Variance; Animals; Bacterial Proteins; Biophysics; Cerebral Cortex; Channelrhodopsins; Cocaine; Dopamine Uptake Inhibitors; Electric Stimulation; Glutamic Acid; Hippocampus; Light; Locomotion; Luminescent Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Microinjections; Neural Pathways; Neurons; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Stilbamidines; Synapses; Transduction, Genetic | 2012 |
Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Calcium Channels; Cocaine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABAergic Neurons; Glutamic Acid; Habenula; Male; Miniature Postsynaptic Potentials; Piperazines; Quinoxalines; Quinpirole; Raclopride; Rats; Receptors, Dopamine; Receptors, Glutamate; Sodium Channels; Synaptic Transmission | 2013 |
Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Central Nervous System Sensitization; Central Nervous System Stimulants; Cocaine; Dopamine; Exocytosis; Gene Expression; Glutamic Acid; Locomotion; Male; Neurons; Nucleus Accumbens; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Restraint, Physical; Stress, Psychological | 2013 |
A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens.
Topics: Animals; Cocaine; Cyclic AMP-Dependent Protein Kinases; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Nucleus Accumbens; Receptor, Serotonin, 5-HT1B; Receptors, Dopamine D1; Receptors, Presynaptic; Serotonin; Serotonin Receptor Agonists; Signal Transduction; Synaptic Transmission | 2013 |
Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation.
Topics: Animals; Cell Count; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dendritic Spines; Environment; GABA Agonists; Glutamic Acid; Long-Term Potentiation; Male; Microinjections; Microscopy, Confocal; Motivation; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA; Recurrence; Self Administration; Synaptic Transmission | 2013 |
Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.
Topics: Acoustic Stimulation; Animals; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Exploratory Behavior; Food Preferences; Gene Expression Regulation; Gene Transfer Techniques; Glutamic Acid; Green Fluorescent Proteins; Homer Scaffolding Proteins; Inhibition, Psychological; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Reflex, Startle; RNA, Small Interfering; Sucrose; Sweetening Agents; Swimming | 2013 |
Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Cocaine; Cocaine-Related Disorders; Data Interpretation, Statistical; Dopamine Agonists; Dopamine Uptake Inhibitors; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Self Administration; Synapses; Up-Regulation | 2013 |
Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus.
Topics: Animals; Cholinergic Neurons; Cocaine; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Miniature Postsynaptic Potentials; Neuronal Plasticity; Nitric Oxide; Patch-Clamp Techniques; Prefrontal Cortex; Presynaptic Terminals; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tegmentum Mesencephali; Tissue Culture Techniques | 2013 |
Role of a hippocampal SRC-family kinase-mediated glutamatergic mechanism in drug context-induced cocaine seeking.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Hippocampus; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; src-Family Kinases | 2013 |
Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Carrier Proteins; Cocaine; Dopamine Uptake Inhibitors; Down-Regulation; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Organ Culture Techniques; Piperazines; Quinolones; Receptors, AMPA; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials; Ventral Tegmental Area | 2013 |
Group I metabotropic glutamate receptors in the medial prefrontal cortex: role in mesocorticolimbic glutamate release in cocaine sensitization.
Topics: Animals; Central Nervous System Sensitization; Cocaine; Glutamic Acid; Locomotion; Male; Methoxyhydroxyphenylglycol; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ventral Tegmental Area | 2013 |
Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy.
Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Choice Behavior; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Functional Neuroimaging; Glutamic Acid; Glutamine; Homeostasis; Humans; Magnetic Resonance Spectroscopy; Male; Oximes; Positron-Emission Tomography; Pyridines; Receptor, Metabotropic Glutamate 5; Self Administration; Young Adult | 2014 |
Stress rapidly dysregulates the glutamatergic synapse in the prefrontal cortex of cocaine-withdrawn adolescent rats.
Topics: Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Swimming; Synapses | 2015 |
Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine.
Topics: Animals; Behavior, Animal; Biosensing Techniques; Blood-Brain Barrier; Cocaine; Cocaine-Related Disorders; Data Interpretation, Statistical; Electrochemistry; Glutamic Acid; Injections, Intravenous; Male; Nucleus Accumbens; Peripheral Nervous System; Rats; Rats, Long-Evans; Reward; Self Administration; Substance-Related Disorders | 2014 |
Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms.
Topics: Action Potentials; Amphetamine; Animals; Cesium; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Feedback, Physiological; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Neurons; Pedunculopontine Tegmental Nucleus; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Synaptic Transmission; Ventral Tegmental Area | 2013 |
Effect of cocaine on ion channels and glutamatergic EPSCs in noradrenergic locus coeruleus neurons.
Topics: Animals; Calcium; Cocaine; Epinephrine; Excitatory Postsynaptic Potentials; Galanin; Glutamic Acid; Ion Channels; Locus Coeruleus; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Sodium | 2014 |
Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Cocaine-Related Disorders; Dendritic Spines; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; In Vitro Techniques; Male; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Synapses; Ventral Tegmental Area | 2014 |
Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; GABAergic Neurons; Gene Expression; Glutamic Acid; Mice; Mice, Knockout; Phosphorylation; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Receptor, Adenosine A2A; Synaptosomes | 2013 |
Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine.
Topics: Acetylcysteine; Animals; Cocaine; Conditioning, Operant; Glutamic Acid; Habits; Male; Membrane Potentials; Neostriatum; Neuronal Plasticity; Rats; Rats, Long-Evans | 2014 |
A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Excitatory Amino Acid Antagonists; Extinction, Psychological; Female; Glutamic Acid; Male; Motivation; Nucleus Accumbens; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Reinforcement Schedule; Self Administration | 2014 |
Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cocaine; Corpus Striatum; Glutamic Acid; Male; Rats; Rats, Wistar | 2014 |
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Basal Forebrain; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Phenethylamines; Purines; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reinforcement, Psychology; Reward; Self Administration; Triazoles | 2015 |
CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking.
Topics: Animals; Cocaine; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neurotransmitter Agents; Patch-Clamp Techniques; Protease Inhibitors; Rats; Receptors, Corticotropin-Releasing Hormone; Self Administration; Synapses; Ventral Tegmental Area | 2014 |
More cocaine-more glutamate-more addiction.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Female; Glutamic Acid; Male; Motivation; Nucleus Accumbens | 2014 |
Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex.
Topics: Amidohydrolases; Animals; Cocaine; Dopamine Uptake Inhibitors; Dyskinesia, Drug-Induced; Endocannabinoids; Glutamic Acid; Glutaminase; Lipoprotein Lipase; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Phospholipase D; Prefrontal Cortex; Receptor, Cannabinoid, CB1; Receptors, Glutamate; RNA, Messenger | 2014 |
Extinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Dopamine Uptake Inhibitors; Extinction, Psychological; Female; Glutamic Acid; Male; Neurons; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Dopamine D1; Repetition Priming; Sex Characteristics; Spatial Behavior | 2015 |
Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking.
Topics: Animals; Astrocytes; Calcium Channels, N-Type; Central Nervous System Agents; Clozapine; Cocaine; Cocaine-Related Disorders; Cues; Dietary Sucrose; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Genetic Therapy; Glutamic Acid; Male; Mice, Transgenic; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Self Administration; SNARE Proteins | 2015 |
Deletion of Gαq in the telencephalon alters specific neurobehavioral outcomes.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gq-G11; Immunoblotting; Immunohistochemistry; Male; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurons; Telencephalon | 2015 |
Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens.
Topics: Animals; Cocaine; Dendritic Spines; Dominance-Subordination; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Green Fluorescent Proteins; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Nucleus Accumbens; Patch-Clamp Techniques; Receptors, Dopamine D1; Receptors, Dopamine D2; Stress, Psychological; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques | 2016 |
Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats.
Topics: Administration, Intravenous; Aging; Amino Acid Transport System X-AG; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Maternal Deprivation; Memantine; Rats; Receptors, N-Methyl-D-Aspartate; Reward; Riluzole; Self Administration; Stress, Psychological | 2015 |
The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Topics: Action Potentials; Adult; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Neurons; Nucleus Accumbens; Opioid-Related Disorders; Self Administration; Signal Transduction; Synaptic Potentials; Vesicular Glutamate Transport Proteins | 2015 |
Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release.
Topics: Anesthetics, Local; Animals; Antiemetics; Cannabidiol; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Immunosuppressive Agents; Indoles; Male; Mice; Seizures; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission.
Topics: Adrenergic Agents; Akathisia, Drug-Induced; Animals; Antiparkinson Agents; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Plasma Membrane Transport Proteins; Glutamic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligodeoxyribonucleotides, Antisense; Oxidopamine; Parkinsonian Disorders; Radiopharmaceuticals; Receptors, G-Protein-Coupled; Stereotyped Behavior; Synaptic Transmission; Time Factors; Tyrosine 3-Monooxygenase | 2015 |
Incubation of cocaine-craving relates to glutamate over-flow within ventromedial prefrontal cortex.
Topics: Animals; Cocaine; Craving; Cues; Dopamine; Glutamic Acid; Prefrontal Cortex; Rats; Self Administration | 2016 |
Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors.
Topics: Animals; Brain; Cocaine; Cues; Dopamine; Drug-Seeking Behavior; GABAergic Neurons; Glutamic Acid; Mice; Mice, Knockout; Neurons; Nucleus Accumbens; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Self Administration | 2016 |
Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Area Under Curve; Ceftriaxone; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Time Factors | 2016 |
Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus.
Topics: Amidohydrolases; Analysis of Variance; Animals; Cocaine; Dopamine Uptake Inhibitors; Endocannabinoids; Gene Expression Regulation; Glutamic Acid; Hippocampus; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, Glutamate; RNA, Messenger; Signal Transduction; Time Factors | 2016 |
Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration.
Topics: Animals; Ceftriaxone; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Comorbidity; Dendritic Spines; Excitatory Amino Acid Agents; Extinction, Psychological; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Stress, Psychological; Synapses | 2016 |
Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cocaine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Extracellular Space; Gene Expression; Glutamic Acid; Mice; Phosphorylation; Prefrontal Cortex; Receptors, Dopamine D1; Serine; Signal Transduction; Time Factors | 2016 |
Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association.
Topics: Animals; Cholinergic Neurons; Cocaine; Conditioning, Psychological; Extinction, Psychological; Food; Glutamic Acid; Interneurons; Mice; Neuronal Plasticity; Nucleus Accumbens; Reinforcement, Psychology | 2016 |
[Effects of 1,3-diphenyl-1,3-propanedione on neurotransmitter contents of brain in mice administered with cocaine].
Topics: Animals; Brain; Brain Chemistry; Cocaine; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Neurotransmitter Agents; Phenylenediamines; Serotonin | 2016 |
Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Male; Mesencephalon; Mice; Mice, Transgenic; Neural Pathways; Neurons; Recurrence; Synapses; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2016 |
Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; In Situ Hybridization; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; RNA, Messenger; Self Administration; Serotonin; Tissue Culture Techniques | 2017 |
Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Behavior, Animal; Cocaine; Corticosterone; Dopamine; Gastrointestinal Microbiome; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Male; Mice; Microbiota; Transcriptome | 2016 |
Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.
Topics: Animals; Cocaine; Dopaminergic Neurons; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Locomotion; Mice; Mice, Knockout; Neuronal Plasticity; Nucleus Accumbens; Prosencephalon; Pyramidal Cells; Synaptic Transmission | 2017 |
Intravenous self-administration of benzydamine, a non-steroidal anti-inflammatory drug with a central cannabinoidergic mechanism of action.
Topics: Administration, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzydamine; Cocaine; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Heroin; Long-Term Synaptic Depression; Narcotics; Neural Pathways; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Self Administration; Synaptic Transmission | 2018 |
Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats.
Topics: Alcohol Drinking; Amino Acid Transport System X-AG; Animals; Cocaine; Ethanol; Glutamic Acid; Male; Neuroglia; Nucleus Accumbens; Prefrontal Cortex; Rats; Substance Withdrawal Syndrome | 2017 |
Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior.
Topics: Amino Acid Transport Systems, Acidic; Ampicillin; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Genetic Predisposition to Disease; Glutamic Acid; Male; Motor Activity; Neuroglia; Nucleus Accumbens; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Self Administration; Sulbactam | 2017 |
Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Male; Mice; Mice, Knockout; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Risk Factors | 2017 |
N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order.
Topics: Acetylcysteine; Animals; Attentional Bias; Cocaine; Cocaine-Related Disorders; Cues; Double-Blind Method; Glutamic Acid; Humans; Motivation; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2017 |
A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cocaine; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Injections, Intraperitoneal; Locus Coeruleus; Mice; Mice, Inbred C57BL; Microtomy; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tissue Culture Techniques | 2017 |
Endogenous glutamate within the prelimbic and infralimbic cortices regulates the incubation of cocaine-seeking in rats.
Topics: Amino Acids; Anesthetics, Local; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Glutamic Acid; Male; Microdialysis; Microinjections; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2018 |
N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse.
Topics: Animals; Cocaine; Comorbidity; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Knockout; Microdialysis; Nucleus Accumbens; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Self Stimulation; Serine; Substance-Related Disorders | 2019 |
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism.
Topics: Animals; Cocaine; Dopamine; Drug-Seeking Behavior; Glutamic Acid; Male; Nucleus Accumbens; Pyridines; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Self Administration | 2018 |
Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Female; Glutamic Acid; Male; Nucleus Accumbens; Oxytocin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 2018 |
Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement.
Topics: Animals; Cocaine; Dependovirus; Excitatory Amino Acid Transporter 2; Extinction, Psychological; Genetic Vectors; Glutamic Acid; Male; Nucleus Accumbens; Rats; Recurrence; Self Administration; Up-Regulation | 2018 |
A neural network for intermale aggression to establish social hierarchy.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Glutamic Acid; Hierarchy, Social; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nerve Net; Neural Conduction; Neurons; Optogenetics; Reward; Ventromedial Hypothalamic Nucleus | 2018 |
Deletion of
Topics: Amygdala; Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Dependovirus; Dopamine; Gene Deletion; Glutamic Acid; Locomotion; Male; Mice; Mice, Knockout; Neoplasm Proteins; Neurons; Nucleus Accumbens; Prefrontal Cortex; Reinforcement, Psychology; Synaptic Transmission | 2018 |
Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cocaine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Synaptic Transmission; Ventral Tegmental Area | 2018 |
Increased cocaine self-administration in rats lacking the serotonin transporter: a role for glutamatergic signaling in the habenula.
Topics: Animals; Behavior, Animal; Cocaine; Depression; Disks Large Homolog 4 Protein; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Gene Knockout Techniques; Glutamic Acid; Habenula; Rats; Rats, Transgenic; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Self Administration; Serotonin Plasma Membrane Transport Proteins | 2019 |
Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Glutamic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neuronal Plasticity; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Receptors, Dopamine D1; Substance-Related Disorders; Synaptic Transmission; Ventral Tegmental Area; Vesicular Glutamate Transport Protein 2 | 2018 |
phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats.
Topics: Alcoholism; Amphetamine; Amygdala; Animals; Brain; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Functional Neuroimaging; gamma-Aminobutyric Acid; Glutamic Acid; Locomotion; Magnetic Resonance Imaging; Microdialysis; Nucleus Accumbens; Rats; Self Administration | 2019 |
Incentive and dopamine sensitization produced by intermittent but not long access cocaine self-administration.
Topics: Animals; Catheterization, Peripheral; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Motivation; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration | 2019 |
Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Cues; Dendritic Spines; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Nucleus Accumbens; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials; Synaptic Transmission | 2020 |
Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone.
Topics: Amino Acid Transport Systems, Acidic; Animals; Biomarkers, Pharmacological; Brain; Ceftriaxone; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Male; NF-E2-Related Factor 2; NF-kappa B; Nucleus Accumbens; Rats; Rats, Wistar; Reward; Self Administration | 2019 |
Amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core.
Topics: Animals; Cocaine; Cues; Drug-Seeking Behavior; Electrodes, Implanted; Glutamic Acid; Male; Nitric Oxide; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration | 2020 |
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization.
Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopaminergic Neurons; gamma-Aminobutyric Acid; Glutamic Acid; Male; Models, Biological; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; Ventral Tegmental Area | 2020 |
Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum.
Topics: Animals; Basal Forebrain; Cocaine; GABAergic Neurons; Glutamic Acid; Humans; Mice | 2020 |
The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration.
Topics: Animals; Cocaine; Glutamic Acid; Male; Prefrontal Cortex; Rats; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission | 2021 |
Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Glutamic Acid; Homeostasis; Humans; Nucleus Accumbens; Self Administration | 2021 |
Hypersensitivity to amphetamine's psychomotor and reinforcing effects in serotonin transporter knockout rats: Glutamate in the nucleus accumbens.
Topics: Amphetamine; Animals; Cocaine; Glutamic Acid; Nucleus Accumbens; Rats; Serotonin Plasma Membrane Transport Proteins | 2020 |
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D
Topics: Animals; Cocaine; Cocaine-Related Disorders; Decision Making; Glutamic Acid; Mesencephalon; Rats; Self Administration | 2020 |
Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Estradiol; Female; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; Motor Activity; Ovariectomy; Prefrontal Cortex; Rats; Rats, Wistar; Taurine | 2020 |
Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens.
Topics: Animals; Cocaine; Enkephalins; Glutamic Acid; Mice; Microdialysis; Nucleus Accumbens | 2021 |
LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats.
Topics: Administration, Intravenous; Aminobutyrates; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Glutamic Acid; Humans; Male; Motivation; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reinforcement, Psychology; Self Administration; Synaptic Transmission | 2021 |
Effects of JL13, a pyridobenzoxazepine compound, in dopaminergic and glutamatergic models of antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Cocaine; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Ketamine; Locomotion; Male; Mice; Oxazepines; Piperazines; Pyridines; Reflex, Startle; Schizophrenia | 2021 |
Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Endocannabinoids; Extinction, Psychological; Glutamic Acid; Homeostasis; Nucleus Accumbens; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration | 2021 |
Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.
Topics: Cocaine; Cocaine-Related Disorders; Glutamic Acid; Habits; Humans; Magnetic Resonance Imaging; Putamen | 2021 |
Cocaine experience induces functional adaptations in astrocytes: Implications for synaptic plasticity in the nucleus accumbens shell.
Topics: Animals; Astrocytes; Calcium Channels; Cocaine; Dose-Response Relationship, Drug; Glutamic Acid; Male; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Self Administration | 2021 |
Long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synapses | 2022 |
Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking.
Topics: Animals; Cell Cycle Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Female; Glutamic Acid; Male; Mice; Nucleus Accumbens; Prefrontal Cortex; Receptors, AMPA; Self Administration; Sex Characteristics; Sucrose; Synapses | 2021 |
CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context.
Topics: Animals; Behavior, Animal; Biomarkers; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Disease Models, Animal; Disease Susceptibility; Extinction, Psychological; Extracellular Space; Glutamic Acid; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Physiological | 2021 |
Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics.
Topics: Alanine; Aspartic Acid; Biomarkers; Chromatography, Liquid; Cocaine; Glutamic Acid; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Metabolic Networks and Pathways; Metabolome; Metabolomics; Multivariate Analysis; Tandem Mass Spectrometry; Taurine | 2021 |
Systemic oxytocin increases glutamate efflux in the nucleus accumbens core of cocaine-experienced male and female rats but only increases dopamine efflux in males.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Drug-Seeking Behavior; Female; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Oxytocin; Rats; Rats, Sprague-Dawley; Self Administration | 2022 |
Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia.
Topics: Animals; Cocaine; Glutamic Acid; Male; Microglia; Minocycline; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2022 |
Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Cocaine; Cocaine-Related Disorders; Female; Glutamic Acid; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Receptors, N-Methyl-D-Aspartate; Self Administration | 2022 |
Responsivity of serotonin transporter knockout rats to short and long access to cocaine: Modulation of the glutamate signalling in the nucleus accumbens shell.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Nucleus Accumbens; Rats; Self Administration; Serotonin Plasma Membrane Transport Proteins | 2022 |
Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice.
Topics: Animals; Cocaine; Dopamine; Glutamic Acid; Halorhodopsins; Male; Mice; Nucleus Accumbens; Ventral Tegmental Area | 2022 |
An allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors reduces the cocaine-stimulated ERK1/2 phosphorylation in the mouse striatum.
Topics: Animals; Cocaine; Corpus Striatum; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; GTP-Binding Proteins; MAP Kinase Signaling System; Mice; Phosphorylation; Receptors, Metabotropic Glutamate | 2023 |
Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice.
Topics: Administration, Intravenous; Animals; Cocaine; Collaborative Cross Mice; Female; Glutamic Acid; Male; Mice; RNA, Ribosomal, 16S | 2023 |
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex.
Topics: Animals; Cocaine; Female; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission | 2023 |
Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; N-Methylaspartate; Nucleus Accumbens; Oxycodone; Rats; Rats, Sprague-Dawley; Self Administration | 2024 |
Amino acid composition of two masticatory nuts (Cola acuminata and Garcinia kola) and a snack nut (Anacardium occidentale).
Topics: Amino Acids; Amino Acids, Acidic; Amino Acids, Essential; Anacardium; Arginine; Aspartic Acid; Cola; Cystine; Garcinia kola; Glutamic Acid; Isoelectric Point; Nuts; Threonine; Valine | 2007 |
Aqueous Extract of
Topics: Adenosine Triphosphatases; Animals; Cola; Garcinia kola; Glutamic Acid; Hippocampus; Hypothalamus; Male; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Water | 2022 |