cocaine has been researched along with gamma-aminobutyric acid in 166 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (6.02) | 18.7374 |
| 1990's | 35 (21.08) | 18.2507 |
| 2000's | 67 (40.36) | 29.6817 |
| 2010's | 45 (27.11) | 24.3611 |
| 2020's | 9 (5.42) | 2.80 |
| Authors | Studies |
|---|---|
| Chebib, M; Johnston, GA | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Molloy, BB; Ryan, JJ; Schmidt, MJ | 1 |
| Arnt, J; Christensen, AV; Scheel-Krüger, J | 1 |
| Luchins, D | 1 |
| Snyder, SH | 1 |
| Cunningham, KA; Lee, MA; Paris, JM | 1 |
| Jimenez-Rivera, CA; Sessler, FM; Stowe, ZN; Waterhouse, BD; Woodward, DJ | 1 |
| Calogero, AE; Chrousos, GP; Gallucci, WT; Gold, PW; Kling, MA | 1 |
| Gale, K | 1 |
| Bhavsar, VH; Dhumal, VR; Gulati, OD | 1 |
| Chermat, R; Kloczko, J; Puech, AJ; Simon, P; Soubrie, P; Thiebot, MH | 1 |
| Starke, K; Weitzell, R | 1 |
| Gale, K; Melis, MR | 1 |
| Berger, PA | 1 |
| Ellison, G; Keys, A | 1 |
| Guminski, BJ; Hooks, MS; Kalivas, PW; Sorg, BA | 1 |
| Duffy, P; Kalivas, PW | 1 |
| Pecins-Thompson, M; Peris, J | 1 |
| Cameron, DL; Williams, JT | 2 |
| Grayson, DR; Levitt, P; Murphy, EH; Wang, XH | 1 |
| Peris, J | 1 |
| Gallagher, JP; McDaniel, WC; Shoji, S; Simms, D | 1 |
| Alexoff, DL; Brodie, JD; Chaurasia, CS; Chen, CE; Clarkson, FA; Dewey, SL; Fowler, JS; Porter, SP; Russo, NB; Straughter-Moore, RM; Tedeschi, D; Volkow, ND | 1 |
| Fischer, I; Friedman, E; Grayson, D; Jones, L; Levitt, P; Murphy, EH; O'Brien-Jenkins, A; Wang, HY; Wang, XH | 1 |
| Carson, WH; Finkenbine, R; King, L; Markowitz, JS; Myrick, H | 1 |
| Koob, GF | 2 |
| Dewey, SL; Kornetsky, C; Kushner, SA | 2 |
| Dewey, SL; Morgan, AE | 1 |
| Bedingfield, JB; Calder, LD; Karler, R; Thai, DK | 1 |
| Gong, W; Justice, JB; Neill, DB | 1 |
| Bokrand, Y; Jung, BJ; Malakhova, O; Peris, J; Resnick, A; Walker, P; Wielbo, D | 1 |
| Cheramy, A; Cole, DG; Cooper, DC; Corbett, R; Fienberg, AA; Girault, J; Grace, AA; Greengard, P; Haile, CN; Hiroi, N; Hyman, SE; Mermelstein, PG; Miller, DB; Nestler, EJ; Nishi, A; O'Callaghan, JP; Onn, SP; Ouimet, CC; Snyder, GL; Song, W; Surmeier, DJ; White, FJ | 1 |
| Ashby, CR; Brodie, JD; Dewey, SL; Fowler, JS; Gardner, EL; Horan, B; Kushner, SA; Logan, J; Morgan, AE; Volkow, ND | 1 |
| Ellison, G; Emre, N; Meshul, CK; Noguchi, K | 1 |
| Appel, SB; Brodie, MS; Costa, E; Davis, JM; Giorgetti, M; Guidotti, A; Javaid, JI | 1 |
| Emre, N; Keys, AS; Mark, GP; Meshul, CK | 1 |
| Ashby, CR; Borda, T; Brodie, JD; Dewey, SL; Gerasimov, MR; Kushner, S; Morgan, AE; Ngosuwan, J; Rohatgi, R | 1 |
| Krnjević, K; Liu, PL; McArdle, JJ; Ren, J; Ye, JH | 1 |
| Koob, GF; Parsons, LH; Weiss, F | 1 |
| Chen, JP; Gardner, E; Hen, R; Scearce-Levie, K | 1 |
| Abumrad, N; Ahmed, N; Ajmal, M; Dewey, S; Fowler, J; Molina, PE; Volkow, N | 1 |
| Andrews, M; Brebner, K; Froestl, W; Phelan, R; Roberts, DC | 1 |
| Dohi, T; Ikeda, T; Kitayama, S; Mitsuhata, C; Morita, K; Sato, T | 1 |
| Brebner, K; Phelan, R; Roberts, DC | 1 |
| De Leon, KR; Stellar, JR; Todtenkopf, MS | 1 |
| Brodie, JD; Dewey, SL; Gerasimov, MR; Lennon, IC; Schiffer, WK; Taylor, SJ | 1 |
| Abel, MS; Kohli, N | 1 |
| Brebner, K; Roberts, DC | 1 |
| Beekman, M; Carter, RB; Dijkstra, D; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Co, C; Sizemore, GM; Smith, JE | 1 |
| Itzhak, Y; Martin, JL | 1 |
| Araujo, DM; Cherry, SR; Kornblum, HI; Tatsukawa, KJ; Toyokuni, T | 1 |
| Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B | 1 |
| Ashby, CR; Brodie, JD; Dewey, SL; Gardner, EL; Gerasimov, MR; Lennon, IC; Marsteller, DA; Schiffer, WK; Taylor, SJ | 1 |
| Levitt, P; Stanwood, GD; Washington, RA | 1 |
| Levitt, P; Shumsky, JS; Stanwood, GD; Washington, RA | 1 |
| Kozell, LB; Meshul, CK | 1 |
| Hyman, SE | 1 |
| Keller, D; Maiya, R; Mayfield, RD; Zahniser, NR | 1 |
| Baunez, C; Bernardi, G; Borrelli, E; Calabresi, P; Centonze, D; Picconi, B; Pisani, A | 1 |
| Abe, S; Baba, A; Hori, T; Okado, N; Suzuki, T; Yamaguchi, M | 1 |
| Bernardi, G; Bracci, E; Calabresi, P; Centonze, D | 1 |
| Dobrovitsky, V; Duarte, A; Froestl, W; Pimentel, P; Stellar, JR; Trzcińska, M | 1 |
| Hotsenpiller, G; Wolf, ME | 1 |
| Kalivas, PW; Lake, R; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX | 1 |
| Elsworth, JD; Morrow, BA; Roth, RH | 1 |
| Collins, ED; Foltin, RW; Haney, M; Hart, CL; Ward, AS | 1 |
| Bhide, PG; Crandall, JE; Hackett, HE; Kosofsky, BE; Tobet, SA | 1 |
| Battista, N; Bernardi, G; Calabresi, P; Centonze, D; Finazzi-Agrò, A; Maccarrone, M; Mercuri, NB; Rossi, S | 1 |
| Stellar, JR; Todtenkopf, MS; Williams, EA; Zahm, DS | 1 |
| Jayaram, P; Steketee, JD | 3 |
| Febo, M; Segarra, AC | 1 |
| Faccidomo, S; Kikusui, T; Miczek, KA | 1 |
| Glaser, PE; Hays, LR; Lile, JA; Rush, CR; Stoops, WW | 1 |
| Burbach, JP; Gerrits, MA; Kamal, A; Lesscher, HM; Mathon, DS; Pintar, JE; Ramakers, GM; Schuller, AG; Smidt, MP; Spruijt, BM; van Ree, JM | 1 |
| Beyer, CE; Steketee, JD | 1 |
| Dallimore, JE; Mackie, AR; McDaid, J; Mickiewicz, AL; Napier, TC | 1 |
| Cagle, S; Kalivas, PW; McFarland, K; Tang, XC | 1 |
| Barrot, M; Bolaños, CA; Choi, KH; Edwards, S; Nestler, EJ; Perrotti, LI; Russo, SJ; Self, DW; Ulery, PG; Wallace, DL | 1 |
| Caillé, S; Parsons, LH | 1 |
| Collins, ED; Foltin, RW; Haney, M; Hart, C | 1 |
| Liu, QS; Poo, MM; Pu, L | 1 |
| Kosten, TR; Sofuoglu, M | 1 |
| Anglard, P; Aunis, D; Burgun, C; Carouge, D; Cassel, S; Dietrich, JB; Gensburger, C; Zwiller, J | 1 |
| Filip, M; Frankowska, M; Gołda, A; Przegaliński, E; Vetulani, J; Zaniewska, M | 2 |
| Steketee, JD | 1 |
| Booze, RM; Buxhoeveden, DP; Buxhoeveden, NE; Hasselrot, U; Mactutus, CF | 1 |
| Collins, ED; Foltin, RW; Haney, M; Hart, CL; Rubin, E | 1 |
| Gardner, EL; Gilbert, JG; Li, X; Pak, AC; Peng, XQ; Xi, ZX | 1 |
| Hsu, KS; Huang, CC; Lin, HJ | 1 |
| Foltin, RW; Haney, M; Hart, CL; Rubin, E; Vosburg, SK | 1 |
| Boutros, N; Stanley, J; Sundaresan, K; Ziemann, U | 1 |
| Battista, N; Bernardi, G; Centonze, D; De Chiara, V; Maccarrone, M; Mercuri, NB; Prosperetti, C; Rossi, S; Usiello, A | 1 |
| Ren, J; Ye, JH | 1 |
| Azari, S; Wang, B; Wise, RA; You, ZB; Zitzman, D | 1 |
| Ashby, CR; Gagare, PD; Gardner, EL; Li, J; Li, X; Peng, XQ; Pratihar, D; Ramachandran, PV; Xi, ZX | 1 |
| Maher, BJ; Westbrook, GL | 1 |
| Kalivas, PW; Torregrossa, MM | 1 |
| Kalivas, PW; Tang, XC; Torregrossa, MM | 1 |
| Aragona, BJ; Carelli, RM; Cleaveland, NA; Day, JJ; Stuber, GD; Wightman, RM | 1 |
| Allison, DW; Barber, EN; Horton, ML; Lyle, LT; Steffensen, SC; Stobbs, SH; Taylor, SR | 1 |
| Hillard, CJ; Liu, QS; Pan, B | 1 |
| Gardner, EL; Li, J; Li, X; Peng, XQ; Spiller, K; Xi, ZX | 1 |
| Barrot, M; Freund-Mercier, MJ; Kaufling, J; Pawlowski, SA; Veinante, P | 2 |
| Dow-Edwards, D; Siegal, N | 1 |
| Lawrence, AJ; Mantamadiotis, T; McPherson, CS; Tan, SS | 1 |
| Chen, J; Freed, WJ; Lee, CT; Worden, LT | 1 |
| Patil, T; Raffa, RB; Rawls, SM; Yuvasheva, E | 1 |
| Kauer, JA; Murali, M; Niehaus, JL | 1 |
| Bisagno, V; Llinás, RR; Peskin, V; Raineri, M; Uchitel, OD; Urbano, FJ; Wikinski, SI | 1 |
| Cheng, PL; Khoshnevisrad, N; Lim, BK; Lu, H; Poo, MM | 1 |
| Centeno, M; Gallagher, JP; Genzer, K; Krishnan, B; Liu, J; Orozco-Cabal, L; Pollandt, S; Schmidt, K; Shinnick-Gallagher, P; Sun, A; Xia, Y | 1 |
| Aston-Jones, G; Luo, AH; Lupica, CR; Tahsili-Fahadan, P; Wise, RA | 1 |
| Bhide, PG; Darnell, SB; McCarthy, DM; Sadri-Vakili, G; Sangrey, GR; Yanagawa, Y; Zhang, X | 1 |
| Gallagher, JP; Genzer, KM; Krishnan, B; Liu, J; Pollandt, SW; Shinnick-Gallagher, P | 1 |
| Ambrosio, E; Botreau, F; Coria, SM; Del Olmo, N; Higuera-Matas, A; Miguéns, M; Olías, O | 1 |
| Bhide, PG; McCarthy, DM | 1 |
| Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Gerra, G; Kallupi, M; Li, H; Somaini, L; Stopponi, S; Ubaldi, M | 1 |
| Bisagno, V; Garcia-Rill, E; Goitia, B; González, LE; Raineri, M; Rozas, JL; Urbano, FJ | 1 |
| Ferraro, L; Filip, M; Fuxe, K; Golembiowska, K; Kamińska, K; Wydra, K; Zaniewska, M | 1 |
| Dominguez, JM; Hattori, T; Nutsch, VL; Roma, PG; Tobiansky, DJ; Will, RG | 1 |
| Baghal, B; Enoch, MA; Goldman, D; Yuan, Q | 1 |
| Edwards, S; Kallupi, M; Koob, GF; Luu, G; Oleata, CS; Roberto, M; Schmeichel, BE; Wee, S; Whitfield, TW | 1 |
| Bézard, E; Caille, S; Chiang, C; DeBacker, J; Di Prospero, C; Doudnikoff, É; Dumont, ÉC; Georges, F; Hawken, ER; Jones, AA; Krawczyk, M; Martinez, A; Mason, X; Normandeau, CP; Sharma, R | 1 |
| Bocklisch, C; de Roo, M; House, DR; Lüscher, C; Pascoli, V; Tan, KR; Wong, JC; Yvon, C | 1 |
| Chung, HJ; Fajardo-Serrano, A; Hearing, M; Kotecki, L; Luján, R; Marron Fernandez de Velasco, E; Wickman, K | 1 |
| Chen, YH; Good, CH; Hoffman, AF; Lupica, CR; Mejias-Aponte, CA; Wang, H | 1 |
| Cheng, K; Kalivas, PW; Kupchik, YM; Rice, KC; Roques, BP; Scofield, MD | 1 |
| Filip, M; Fuxe, K; Gołembiowska, K; Kamińska, K; Suder, A; Wydra, K | 1 |
| Craige, CP; Kirby, LG; Lewandowski, S; Unterwald, EM | 1 |
| Abarca, J; Andrés, ME; Araya, KA; Gysling, K; Renard, GM; Sotomayor-Zárate, R | 1 |
| Cheer, JF; Covey, DP; Lupica, CR; Treadway, T; Wang, H | 1 |
| Bisagno, V; Garcia-Rill, E; Gingrich, JA; Goitia, B; Rivero-Echeto, MC; Urbano, FJ; Weisstaub, NV | 1 |
| Briggs, SB; Keralapurath, MM; Wagner, JJ | 1 |
| Carlton, S; Cunningham, KA; Hommel, JD; Huang, M; Kasper, JM; McCue, DL; Meltzer, HY; Milton, AJ; Sampson, CM; Szwed, A | 1 |
| Chen, J; Cui, R; Liu, XX; Wang, YC; Zhang, BX | 1 |
| Diana, MA; Mameli, M; Meye, FJ; Schwarz, MK; Smit, T; Soiza-Reilly, M | 1 |
| Bradshaw, H; Chiou, LC; Hung, MS; Hwang, LL; Lee, HJ; Lee, YH; Leishman, E; Lu, GL; Mackie, K; Tung, LW; Yu, L; Zimmer, A | 1 |
| Herman, MA; Koob, GF; Roberto, M; Schmeichel, BE | 1 |
| Kamiizawa, R; Kaneda, K; Minami, M; Taoka, N; Wada, S | 1 |
| Álvarez-Dolado, M; Castilla-Ortega, E; Ladrón de Guevara-Miranda, D; Martínez-Losa, M; Millón, C; Missiroli, M; Pavón, FJ; Pérez-Fernández, M; Rodríguez de Fonseca, F; Rosell-Valle, C; Santín, LJ; Serrano, A | 1 |
| Chang, S; Choi, KH; Gwak, YS; Jang, EY; Jin, W; Kim, HY; Kim, JH; Kim, MS; Koo, H; Lee, BH; Lee, JG; Lee, JY; Ryu, YH; Steffensen, SC; Yang, CH; Yoon, SS | 1 |
| Li, Y; Liu, QS; Liu, X; Vickstrom, C; Zhong, P | 1 |
| Li, Y; Liu, QS; Yu, L; Zeng, F; Zhao, L | 1 |
| Bergman, J; Carlezon, WA; Coyle, JT; Desai, RI; Donahue, RJ; Doyle, MR; Landino, SM; Presti, KT; Puhl, MD; Takagi, S | 1 |
| Bading, H; Baur, K; Bengtson, CP; Bernardi, RE; Hach, A; Spanagel, R | 1 |
| Liu, K; Steketee, JD | 1 |
| Bifone, A; Cannella, N; Ciccocioppo, R; Cippitelli, A; Domi, E; Gozzi, A; Li, H; Matzeu, A; Scuppa, G; Ubaldi, M; Weiss, F | 1 |
| Jimenez-Rivera, CA; Santos-Vera, B; Vazquez-Torres, R; Velasquez-Martinez, MC; Velez-Hernandez, ME | 1 |
| Calleti, G; Flores Peres, V; Fraga de Souza, M; Freese, L; Gomez, R; Maria Tannhauser Barros, H; Schüler Nin, M | 1 |
| Khayat, A; Weitz, M; Yaka, R | 1 |
| Cunningham, KA; Hommel, JD; Kasper, JM; Miller, SN; Russell, WK; Smith, AE | 1 |
| Ly, A; Root, DH | 1 |
| Alvarez, VA; Blegen, MB; Bocarsly, ME; Choi, IB; Dai, KZ; Dobbs, LK; Kaplan, AR; Kellendonk, C; Levitt, R; Matsui, A; Shin, JH; Simpson, EH | 1 |
| Baraban, JM; Chen, J; Chen, KH; Liu, Y; Qiu, Z; Yang, J | 1 |
| Qiu, Z; Yang, J | 1 |
| Belelli, D; Dixon, CI; Janak, PH; King, SL; Lambert, JJ; Macpherson, T; Robertson, J; Sindarto, MM; Stephens, DN | 1 |
| Kometani, T; Nakamura, H; Takishima, T; Yokogoshi, H | 1 |
7 review(s) available for cocaine and gamma-aminobutyric acid
| Article | Year |
|---|---|
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Ion Channels; Ligands; Receptors, GABA; Receptors, GABA-A; Structure-Activity Relationship | 2000 |
Biochemistry and the schizophrenia. Old concepts and new hypothesis.
Topics: Acetylcholine; Amphetamine; Animals; Brain; Cocaine; Dopamine; Endorphins; gamma-Aminobutyric Acid; Humans; Methylphenidate; Naloxone; Norepinephrine; Phenethylamines; Physostigmine; Schizophrenia; Schizophrenia, Paranoid | 1981 |
Drug abuse and alcoholism. Overview.
Topics: Alcoholism; Animals; Brain; Cocaine; Dopamine; Emotions; gamma-Aminobutyric Acid; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Neurons; Neuropeptides; Polymorphism, Genetic; Receptors, Dopamine; Receptors, Serotonin; Substance-Related Disorders; Vesicular Biogenic Amine Transport Proteins | 1998 |
Circuits, drugs, and drug addiction.
Topics: Amygdala; Animals; Benzazepines; Brain; Cocaine; Dextroamphetamine; Dopamine; gamma-Aminobutyric Acid; Humans; Motor Activity; Receptors, Dopamine; Reinforcement, Psychology; Substance-Related Disorders | 1998 |
GABA modulation of cocaine self-administration.
Topics: Animals; Baclofen; Cocaine; Conditioning, Psychological; gamma-Aminobutyric Acid; Organophosphonates; Phosphinic Acids; Reinforcement, Psychology; Self Administration | 2000 |
Emerging pharmacological strategies in the fight against cocaine addiction.
Topics: Adrenergic beta-Antagonists; Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Disulfiram; Dopamine; Dopamine Agents; Dopamine beta-Hydroxylase; Drug Evaluation, Preclinical; Enzyme Inhibitors; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Modafinil; Nipecotic Acids; Propranolol; Randomized Controlled Trials as Topic; Tiagabine; Vaccines | 2006 |
Cortical mechanisms of cocaine sensitization.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Prefrontal Cortex; Receptors, Dopamine; Receptors, GABA; Receptors, Glutamate; Synaptic Transmission | 2005 |
5 trial(s) available for cocaine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans.
Topics: Acetates; Adult; Amines; Blood Pressure; Choice Behavior; Cocaine; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Heart Rate; Humans; Male; Self Administration; Smoking; Surveys and Questionnaires | 2004 |
Smoked cocaine discrimination in humans: effects of gabapentin.
Topics: Administration, Inhalation; Adult; Amines; Arousal; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Psychomotor Performance | 2005 |
Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses.
Topics: Adult; Blood Pressure; Choice Behavior; Cocaine; Cross-Over Studies; Double-Blind Method; Female; GABA Agonists; gamma-Aminobutyric Acid; Heart Rate; Humans; Male; Self Administration; Smoking; Surveys and Questionnaires | 2007 |
Gabapentin does not reduce smoked cocaine self-administration: employment of a novel self-administration procedure.
Topics: Adult; Affect; Ambulatory Care; Amines; Arousal; Blood Pressure; Choice Behavior; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Euphoria; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Heart Rate; Humans; Male; Motivation; Patient Admission; Self Administration; Token Economy; Treatment Failure | 2007 |
Psychological stress-reducing effect of chocolate enriched with gamma-aminobutyric acid (GABA) in humans: assessment of stress using heart rate variability and salivary chromogranin A.
Topics: Adult; Algorithms; Autonomic Nervous System; Cacao; Candy; Chromogranin A; Cross-Over Studies; Double-Blind Method; Functional Food; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Humans; Male; Saliva; Stress, Psychological; Task Performance and Analysis; Time Factors | 2009 |
154 other study(ies) available for cocaine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Effects of kainic acid, a cyclic analogue of glutamic acid, on cyclic nucleotide accumulation in slices of rat cerebellum.
Topics: Animals; Brain Stem; Calcium; Cerebellum; Cocaine; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Male; Norepinephrine; Potassium; Rats; Stimulation, Chemical; Structure-Activity Relationship; Theophylline; Time Factors | 1976 |
Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: a complex GABA-dopamine interaction.
Topics: Animals; Apomorphine; Basidiomycota; Behavior; Cocaine; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Methylphenidate; Methyltyrosines; Mice; Motor Activity; Oxazoles; Stereotyped Behavior | 1978 |
The dopamine hypothesis of schizophrenia. A critical analysis.
Topics: Acetylcholine; Amphetamine; Apomorphine; Cocaine; Dopamine; Electroconvulsive Therapy; gamma-Aminobutyric Acid; Humans; Levodopa; Methyldopa; Methyltyrosines; Models, Neurological; Psychoses, Substance-Induced; Schizophrenia; Tranquilizing Agents | 1975 |
Neuroscience. Vehicles of inactivation.
Topics: Animals; Antidepressive Agents; Carrier Proteins; Cloning, Molecular; Cocaine; Dopamine; gamma-Aminobutyric Acid; Neurotransmitter Agents; Norepinephrine; Serotonin | 1991 |
Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala.
Topics: Amygdala; Animals; Cocaine; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Neurons; Rats; Rats, Inbred Strains; Reference Values; Stereotyped Behavior | 1991 |
Cocaine actions in a central noradrenergic circuit: enhancement of cerebellar Purkinje neuron responses to iontophoretically applied GABA.
Topics: Animals; Benzylamines; Cerebellum; Cocaine; Dose-Response Relationship, Drug; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Norepinephrine; Purkinje Cells; Rats; Serotonin; Sympathomimetics | 1991 |
Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro.
Topics: Animals; Cocaine; Corticotropin-Releasing Hormone; Dexamethasone; gamma-Aminobutyric Acid; Hypothalamus; Male; Organ Culture Techniques; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Catecholamine-independent behavioral and neurochemical effects of cocaine in rats.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Brain Chemistry; Catecholamines; Cocaine; Corpus Striatum; Droperidol; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Rats; Receptors, Dopamine; Receptors, GABA-A; Stereotyped Behavior; Taste; Time Factors | 1984 |
Central hypotensive effect of gamma-aminobutyric acid in anaesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Brain; Cocaine; Depression, Chemical; Dogs; Epinephrine; Female; gamma-Aminobutyric Acid; Male; Norepinephrine; Reserpine | 1980 |
Enhancement of cocaine-induced hyperactivity in mice by benzodiazepines: evidence for an interaction of GABAergic processes with catecholaminergic neurons?
Topics: Animals; Benzodiazepines; Catecholamines; Cocaine; Drug Synergism; gamma-Aminobutyric Acid; Humans; Hyperkinesis; Male; Mice; Neurons; Synaptic Transmission | 1981 |
gamma-Aminobutyric acid and postganglionic sympathetic transmission in the pulmonary artery of the rabbit.
Topics: Animals; Autonomic Fibers, Postganglionic; Cocaine; Drug Interactions; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Muscle, Smooth, Vascular; Potassium; Pulmonary Artery; Rabbits; Sympathetic Nervous System; Synaptic Transmission; Yohimbine | 1980 |
Effect of dopamine agonists on gamma-aminobutyric acid (GABA) turnover in the superior colliculus: evidence that nigrotectal GABA projections are under the influence of dopaminergic transmission.
Topics: Animals; Apomorphine; Bicuculline; Cocaine; Dextroamphetamine; Dopamine; gamma-Aminobutyric Acid; Male; Microinjections; Muscimol; Rats; Rats, Inbred Strains; Substantia Nigra; Superior Colliculi | 1983 |
Continuous cocaine induces persisting alterations in dopamine overflow in caudate following perfusion with a D1 agonist.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Drug Implants; Feedback; Female; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; Microdialysis; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Thalamus | 1994 |
Cocaine alters glutamic acid decarboxylase differentially in the nucleus accumbens core and shell.
Topics: Analysis of Variance; Animals; Cocaine; Drug Administration Schedule; Enkephalins; gamma-Aminobutyric Acid; Genetic Code; Glutamate Decarboxylase; Male; Neurons; Nucleus Accumbens; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Tachykinins | 1995 |
D1 receptors modulate glutamate transmission in the ventral tegmental area.
Topics: Animals; Benzazepines; Cocaine; Dopamine Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Synaptic Transmission; Tegmentum Mesencephali | 1995 |
Behavioral and neurochemical changes caused by repeated ethanol and cocaine administration.
Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Convulsants; Dopamine; Ethanol; gamma-Aminobutyric Acid; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-A; Spiperone; Substantia Nigra | 1993 |
Cocaine inhibits GABA release in the VTA through endogenous 5-HT.
Topics: Animals; Cocaine; Dopamine; Electrophysiology; Fenfluramine; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Neurons; p-Chloroamphetamine; Presynaptic Terminals; Serotonin; Synaptic Transmission; Tegmentum Mesencephali | 1994 |
Intrauterine cocaine exposure of rabbits: persistent elevation of GABA-immunoreactive neurons in anterior cingulate cortex but not visual cortex.
Topics: Animals; Cell Count; Cocaine; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Immunohistochemistry; Neurons; Nissl Bodies; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Visual Cortex | 1995 |
Opposing roles for dopamine and serotonin at presynaptic receptors in the ventral tegmental area.
Topics: Animals; Cocaine; Dopamine; Dopamine Agonists; gamma-Aminobutyric Acid; Guinea Pigs; Receptors, Dopamine D1; Receptors, Presynaptic; Serotonin; Synaptic Transmission; Ventral Tegmental Area | 1995 |
Repeated cocaine injections decrease the function of striatal gamma-aminobutyric acid(A) receptors.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Locomotion; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1996 |
Chronic cocaine enhances gamma-aminobutyric acid and glutamate release by altering presynaptic and not postsynaptic gamma-aminobutyric acidB receptors within the rat dorsolateral septal nucleus.
Topics: Animals; Bicuculline; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Septal Nuclei; Synaptic Transmission | 1997 |
GABAergic attenuation of cocaine-induced dopamine release and locomotor activity.
Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Corpus Striatum; Dopamine; Enzyme Inhibitors; Ethanol; GABA Modulators; gamma-Aminobutyric Acid; Lorazepam; Male; Microdialysis; Motor Activity; Rats; Rats, Sprague-Dawley; Time Factors; Vigabatrin | 1997 |
Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures.
Topics: Animals; Biomarkers; Cerebral Cortex; Cocaine; Dendrites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; gamma-Aminobutyric Acid; Maternal-Fetal Exchange; Microtubule-Associated Proteins; Narcotics; Nerve Tissue Proteins; Parvalbumins; Pregnancy; Pyramidal Cells; Rabbits; Seizures | 1997 |
Gabapentin abuse in a cocaine user: implications for treatment?
Topics: Acetates; Adult; Amines; Anticonvulsants; Crack Cocaine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Self Medication; Stress Disorders, Post-Traumatic; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred F344; Reward; Vigabatrin | 1997 |
Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine.
Topics: Animals; Cocaine; Dopamine; gamma-Aminobutyric Acid; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Vigabatrin | 1998 |
The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine.
Topics: Amphetamine; Animals; Bicuculline; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Frontal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Models, Neurological; Motor Activity; Stereotyped Behavior; Sulpiride | 1998 |
GABAergic modulation of ventral pallidal dopamine release studied by in vivo microdialysis in the freely moving rat.
Topics: Animals; Baclofen; Cocaine; Dopamine; Dopamine Uptake Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Picrotoxin; Piperazines; Rats; Rats, Wistar | 1998 |
Antisense inhibition of striatal GABAA receptor proteins decreases GABA-stimulated chloride uptake and increases cocaine sensitivity in rats.
Topics: Analysis of Variance; Animals; Chlorides; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Half-Life; Male; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Synaptic Transmission | 1998 |
DARPP-32: regulator of the efficacy of dopaminergic neurotransmission.
Topics: Amphetamines; Animals; Behavior, Animal; Calcium; Cocaine; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agents; Dopamine and cAMP-Regulated Phosphoprotein 32; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Gene Targeting; Genes, fos; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Raclopride; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Salicylamides; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 1998 |
A novel strategy for the treatment of cocaine addiction.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Catalepsy; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Female; Food; gamma-Aminobutyric Acid; Male; Motor Activity; Papio; Rats; Rats, Sprague-Dawley; Vigabatrin | 1998 |
Cocaine-induced changes in glutamate and GABA immunolabeling within rat habenula and nucleus accumbens.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Female; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Immunohistochemistry; Microscopy, Electron; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 1998 |
Imidazenil, a positive allosteric GABAA receptor modulator, inhibits the effects of cocaine on locomotor activity and extracellular dopamine in the nucleus accumbens shell without tolerance liability.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Cocaine; Corpus Striatum; Diazepam; Dopamine; Drug Tolerance; GABA Modulators; gamma-Aminobutyric Acid; Imidazoles; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, GABA-A; Ventral Tegmental Area | 1998 |
Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome; Synaptic Vesicles; Time Factors | 1998 |
Implication of the GABA(B) receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Male; Morpholines; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Vigabatrin | 1999 |
Cocaine and lidocaine have additive inhibitory effects on the GABAA current of acutely dissociated hippocampal pyramidal neurons.
Topics: Anesthetics, Combined; Animals; Cocaine; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Channels | 1999 |
RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine.
Topics: Animals; Brain Chemistry; Cocaine; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Indoles; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1999 |
The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Conditioning, Operant; Enzyme Inhibitors; Food; gamma-Aminobutyric Acid; Male; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration; Vigabatrin | 1999 |
5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Dopamine; Dopamine Antagonists; Feeding Behavior; gamma-Aminobutyric Acid; Indoles; Mental Disorders; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Substance-Related Disorders | 1999 |
Co-administration of gamma-vinyl GABA and cocaine: preclinical assessment of safety.
Topics: 4-Aminobutyrate Transaminase; Alanine Transaminase; Animals; Cocaine; Electrocardiography; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hemodynamics; Lactic Acid; Liver; Male; Rats; Rats, Sprague-Dawley; Vigabatrin | 1999 |
The GABA(B) agonist CGP 44532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Eating; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Male; Organophosphonates; Phosphinic Acids; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration | 1999 |
Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics.
Topics: Anesthetics, Local; Animals; Carrier Proteins; Cocaine; COS Cells; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; HeLa Cells; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Procaine; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 2000 |
Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Male; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration | 2000 |
An examination of glutamate decarboxylase(65) immunoreactive puncta with respect to rat ventral pallidum neurons after repeated cocaine administration.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug Administration Schedule; gamma-Aminobutyric Acid; Globus Pallidus; Glutamate Decarboxylase; Immunohistochemistry; Isoenzymes; Male; Neural Pathways; Neurons; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2000 |
gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microdialysis; Molecular Mimicry; Nipecotic Acids; Oximes; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Sodium Chloride | 2000 |
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Cerebral Ventricles; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Injections; Male; Mice; Mice, Inbred BALB C; Neurons; Oligodeoxyribonucleotides, Antisense; Pentylenetetrazole; Seizures; Time Factors | 1999 |
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Pregnenolone; Psychotropic Drugs; Steroids; Synaptic Transmission | 2000 |
Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats.
Topics: Animals; Cocaine; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred F344; Self Administration; Serotonin | 2000 |
Effect of riluzole and gabapentin on cocaine- and methamphetamine-induced behavioral sensitization in mice.
Topics: Acetates; Amines; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cyclohexanecarboxylic Acids; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Methamphetamine; Mice; Motor Activity; Riluzole; Time Factors | 2000 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Energy Metabolism; Female; Fluorodeoxyglucose F18; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Huntington Disease; In Situ Hybridization; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Spiperone; Substantia Nigra; Tomography, Emission-Computed; Tritium | 2000 |
Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.
Topics: Animals; Arrhythmias, Cardiac; Cocaine; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine.
Topics: 4-Aminobutyrate Transaminase; Animals; Cocaine; Conditioning, Psychological; Cues; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vigabatrin | 2001 |
Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Dendrites; Dopamine Uptake Inhibitors; Female; gamma-Aminobutyric Acid; Immunohistochemistry; In Situ Hybridization; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Parvalbumins; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits | 2001 |
Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex.
Topics: Animals; Animals, Newborn; Axons; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Dendrites; Dopamine; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Microtubule-Associated Proteins; Neurons; Parvalbumins; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Tyrosine 3-Monooxygenase | 2001 |
The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Motor Activity; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2001 |
A 28-year-old man addicted to cocaine.
Topics: Acetates; Adult; Amines; Brain; Cocaine-Related Disorders; Cost of Illness; Crack Cocaine; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Risk Factors | 2001 |
Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes.
Topics: Animals; Carrier Proteins; Central Nervous System Depressants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ethanol; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kinetics; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; Rats; Receptors, Cell Surface; RNA; Xenopus | 2001 |
Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamine; Animals; Cocaine; Denervation; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Mice; Mice, Transgenic; Neostriatum; Neural Pathways; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Dopamine D2; Synaptic Transmission | 2002 |
Repeated cocaine administration increases GABA(B(1)) subunit mRNA in rat brain.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Tolerance; gamma-Aminobutyric Acid; Male; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; RNA, Messenger; Synaptic Transmission; Up-Regulation | 2002 |
Dopamine excites fast-spiking interneurons in the striatum.
Topics: Action Potentials; Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Evoked Potentials; gamma-Aminobutyric Acid; Interneurons; Male; Membrane Potentials; Rats; Rats, Wistar; Reaction Time; Synapses | 2002 |
CGP 44532, a GABAB receptor agonist, is hedonically neutral and reduces cocaine-induced enhancement of reward.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Organophosphonates; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Reaction Time; Reward | 2002 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reward; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.
Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Drug Administration Schedule; Extracellular Space; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Nucleus Accumbens; Phosphorylation; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Axo-axonic structures in the medial prefrontal cortex of the rat: reduction by prenatal exposure to cocaine.
Topics: Animals; Axons; Carrier Proteins; Cell Count; Cocaine; Cognition Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Organic Anion Transporters; Parvalbumins; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Presynaptic Terminals; Pyramidal Cells; Rats | 2003 |
Cocaine exposure decreases GABA neuron migration from the ganglionic eminence to the cerebral cortex in embryonic mice.
Topics: Animals; Cell Movement; Cerebral Cortex; Cocaine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Median Eminence; Mice; Neurons; Olfactory Bulb | 2004 |
A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amidohydrolases; Animals; Arachidonic Acids; Cerebral Cortex; Cocaine; Cyclohexanols; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neostriatum; Patch-Clamp Techniques; Polyunsaturated Alkamides; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Synaptic Transmission; Synaptosomes | 2004 |
Differential distribution of parvalbumin immunoreactive neurons in the striatum of cocaine sensitized rats.
Topics: Animals; Cell Count; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; Drug Tolerance; gamma-Aminobutyric Acid; Immunohistochemistry; Interneurons; Male; Neostriatum; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Parvalbumins; Rats; Rats, Sprague-Dawley; Up-Regulation | 2004 |
Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine system.
Topics: Animals; Baclofen; Behavior, Animal; Cocaine; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Synergism; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Receptors, GABA-B; Synaptic Transmission; Ventral Tegmental Area | 2004 |
Cocaine alters GABA(B)-mediated G-protein activation in the ventral tegmental area of female rats: modulation by estrogen.
Topics: Animals; Autoradiography; Baclofen; Cocaine; Dopamine Uptake Inhibitors; Entorhinal Cortex; Enzyme Activation; Estrogens; Female; GABA Agonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ovariectomy; Rats; Receptors, GABA-B; Ventral Tegmental Area | 2004 |
Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female mice.
Topics: Animals; Arousal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Proteins; Female; gamma-Aminobutyric Acid; Hippocampus; Hypothalamo-Hypophyseal System; Male; Maternal Deprivation; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Pituitary-Adrenal System; Receptors, Glucocorticoid; Recurrence; Risk Factors; Sex Factors | 2005 |
Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans.
Topics: Administration, Oral; Adult; Analysis of Variance; Cocaine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Humans; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Tiagabine | 2004 |
Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.
Topics: Afferent Pathways; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Neural Inhibition; Neurons; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Synapses; Synaptic Transmission; Up-Regulation; Ventral Tegmental Area | 2005 |
Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in rats.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA-B | 2005 |
Cross-sensitization to morphine in cocaine-sensitized rats: behavioral assessments correlate with enhanced responding of ventral pallidal neurons to morphine and glutamate, with diminished effects of GABA.
Topics: Action Potentials; Animals; Behavior, Animal; Cocaine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Morphine; Motor Activity; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2005 |
Effects of cocaine-induced behavioural sensitization on GABA transmission within rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Extracellular Space; gamma-Aminobutyric Acid; Male; Microdialysis; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Blotting, Western; Carnitine Acyltransferases; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Extinction, Psychological; Food; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Microinjections; Mitochondrial Proteins; Morphine; Motor Activity; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Somatostatin; Time Factors | 2005 |
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment.
Topics: Animals; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Kinetics; Male; Morphine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Self Administration; Transcription Factors; Ventral Tegmental Area | 2005 |
Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Cannabinoids; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine; Drug Administration Routes; Drug Interactions; gamma-Aminobutyric Acid; Male; Microdialysis; Morphine; Neural Pathways; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration; Time Factors | 2006 |
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons.
Topics: Animals; Bicuculline; Cocaine; Diazepam; Dopamine; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Potentiation; Male; Memory; Mesencephalon; Neuronal Plasticity; Neurons; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses | 2005 |
Cocaine-induced increases in medial prefrontal cortical GABA transmission involves glutamatergic receptors.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Cocaine; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Male; Microdialysis; Motor Activity; Piperazines; Prefrontal Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2006 |
Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cocaine; DNA-Binding Proteins; Epigenesis, Genetic; Fluoxetine; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Methyl-CpG-Binding Protein 2; Rats; Rats, Wistar; RNA, Messenger; Serotonin | 2006 |
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.
Topics: Amines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Male; Motor Activity; Nipecotic Acids; Rats; Rats, Wistar; Tiagabine; Vigabatrin | 2006 |
Microanatomy in 21 day rat brains exposed prenatally to cocaine.
Topics: Animals; Brain; Cell Differentiation; Cocaine; Cocaine-Related Disorders; Dendrites; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intravenous; Male; Nervous System Malformations; Neural Pathways; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2006 |
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Recurrence; Reward | 2006 |
Repeated cocaine administration promotes long-term potentiation induction in rat medial prefrontal cortex.
Topics: Animals; Benzazepines; Carbazoles; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electrophysiology; Enzyme Inhibitors; gamma-Aminobutyric Acid; Indoles; Long-Term Potentiation; Male; Motor Activity; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Pyrroles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Dopamine D1; Receptors, GABA-A; Stimulation, Chemical | 2007 |
Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats.
Topics: Amines; Animals; Behavior, Animal; Cocaine; Cyclohexanecarboxylic Acids; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Tiagabine; Vigabatrin | 2007 |
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.
Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Evoked Potentials, Motor; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Motor Cortex; Neural Inhibition; Substance Withdrawal Syndrome; Synaptic Transmission; Transcranial Magnetic Stimulation | 2007 |
Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses | 2007 |
Cocaine inhibition of GABA(A) current: role of dephosphorylation.
Topics: Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hippocampus; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Rats; Receptors, GABA-A; Seizures | 2006 |
A role for conditioned ventral tegmental glutamate release in cocaine seeking.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Long-Evans; Reinforcement, Psychology; Ventral Tegmental Area | 2007 |
Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats.
Topics: Amines; Animals; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Disruptive, Impulse Control, and Conduct Disorders; Dopamine; Gabapentin; gamma-Aminobutyric Acid; Male; Nucleus Accumbens; Rats; Rats, Long-Evans; Recurrence; Self Administration; Vasoconstrictor Agents | 2008 |
Co-transmission of dopamine and GABA in periglomerular cells.
Topics: Analysis of Variance; Animals; Animals, Newborn; Baclofen; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Interneurons; Mice; Mice, Inbred DBA; Mice, Transgenic; Olfactory Bulb; Olfactory Receptor Neurons; Sulpiride; Tyrosine 3-Monooxygenase | 2008 |
Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Male; Motor Activity; Neurotensin; Peptide Fragments; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Self Administration | 2008 |
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA.
Topics: Animals; Basal Ganglia; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA Agonists; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Microdialysis; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission | 2008 |
Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events.
Topics: Action Potentials; Animals; Brain Chemistry; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; gamma-Aminobutyric Acid; Male; Microinjections; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2008 |
Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels.
Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Methamphetamine; Neural Inhibition; Neurons; Rats; Rats, Wistar; Receptors, Dopamine D2; Reward; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission; Ventral Tegmental Area | 2008 |
D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Chromones; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Drug Combinations; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mesencephalon; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2 | 2008 |
Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism.
Topics: Administration, Oral; Animals; Behavior, Animal; Benzhydryl Compounds; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; gamma-Aminobutyric Acid; Globus Pallidus; GluK3 Kainate Receptor; Male; Microdialysis; Motor Activity; Rats; Rats, Long-Evans; Receptors, Kainic Acid; Reinforcement Schedule; Reward; Self Administration; Sucrose; Sweetening Agents | 2009 |
Afferents to the GABAergic tail of the ventral tegmental area in the rat.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2009 |
Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats.
Topics: Anesthetics, Inhalation; Animals; Body Weight; Cocaine; Estrous Cycle; Female; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Sex Factors; Stereotyped Behavior | 2009 |
Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Classical; Conditioning, Operant; Cyclic AMP Response Element-Binding Protein; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Homeodomain Proteins; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Motor Activity; Mutation; Parvalbumins; Pyramidal Cells; Self Administration; Spatial Behavior; Swimming; Telencephalon; Transcription Factors | 2010 |
gamma-Aminobutyric acid cells with cocaine-induced DeltaFosB in the ventral tegmental area innervate mesolimbic neurons.
Topics: Animals; Biotin; Cholera Toxin; Cocaine; Dextrans; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Limbic System; Male; Neural Pathways; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stilbamidines; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2010 |
Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex.
Topics: Animals; Cell Movement; Cerebral Cortex; Cocaine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley | 2011 |
First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.
Topics: Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypnotics and Sedatives; Methamphetamine; Motor Activity; Muscarinic Antagonists; Planarians; Scopolamine; Substance Withdrawal Syndrome; Substance-Related Disorders | 2010 |
Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area.
Topics: Analgesics, Opioid; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Illicit Drugs; Long-Term Potentiation; Morphine; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stress, Physiological; Synapses; Ventral Tegmental Area | 2010 |
Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; gamma-Aminobutyric Acid; Locomotion; Male; Mibefradil; Mice; Mice, Inbred C57BL; Nickel; Octanols; Patch-Clamp Techniques; Thalamus | 2010 |
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocaine-Related Disorders; Diazepam; Disease Models, Animal; Dopamine Uptake Inhibitors; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression Regulation; Green Fluorescent Proteins; Immunoprecipitation; In Vitro Techniques; Indole Alkaloids; Locomotion; Long-Term Potentiation; Neurotransmitter Agents; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Transfection | 2010 |
Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Long-Term Potentiation; Male; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 2011 |
Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area.
Topics: Action Potentials; Animals; Behavior, Animal; Brain Mapping; CA3 Region, Hippocampal; Cocaine; Dopamine; Drug-Seeking Behavior; Electric Stimulation; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Models, Neurological; Neural Inhibition; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Septal Nuclei; Theta Rhythm; Ventral Tegmental Area | 2011 |
Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain.
Topics: Age Factors; Animals; Brain-Derived Neurotrophic Factor; Cell Death; Cell Movement; Cocaine; DNA-Binding Proteins; Embryo, Mammalian; Female; gamma-Aminobutyric Acid; Gene Knock-In Techniques; Glutamate Decarboxylase; Mice; Neurogenesis; Neurons; Nuclear Proteins; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prosencephalon; T-Box Domain Proteins; Thyroid Nuclear Factor 1; Transcription Factors | 2011 |
Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Benzazepines; Cocaine; Conditioning, Psychological; Cues; Cyclopropanes; Dopamine; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Glycine; Isoenzymes; Long-Term Potentiation; Male; Memory; Neuronal Plasticity; Phospholipase D; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome; Synapses | 2011 |
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophoresis, Capillary; Extinction, Psychological; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred F344; Rats, Inbred Lew; Recurrence; Self Administration; Sodium Chloride; Species Specificity | 2013 |
Prenatal cocaine exposure decreases parvalbumin-immunoreactive neurons and GABA-to-projection neuron ratio in the medial prefrontal cortex.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Transgenic; Neurons; Parvalbumins; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects | 2012 |
Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Animals; Anticonvulsants; Cocaine; Cocaine-Related Disorders; Cues; Discrimination Learning; Drug-Seeking Behavior; Feeding Behavior; gamma-Aminobutyric Acid; Humans; Male; Pregabalin; Rats; Rats, Wistar; Reinforcement, Psychology; Secondary Prevention; Self Administration; Stress, Physiological; Yohimbine | 2013 |
Differential effects of methylphenidate and cocaine on GABA transmission in sensory thalamic nuclei.
Topics: Animals; Blotting, Western; Central Nervous System Stimulants; Cocaine; gamma-Aminobutyric Acid; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Synaptic Transmission; Thalamic Nuclei | 2013 |
Accumbal and pallidal dopamine, glutamate and GABA overflow during cocaine self-administration and its extinction in rats.
Topics: Analysis of Variance; Animals; Basal Ganglia; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamates; Male; Microdialysis; Nucleus Accumbens; Potassium Chloride; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration; Sodium Chloride; Substance Withdrawal Syndrome; Synaptic Transmission; Time Factors | 2013 |
The medial preoptic area modulates cocaine-induced activity in female rats.
Topics: Animals; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Female; gamma-Aminobutyric Acid; Motor Activity; Neurons; Nucleus Accumbens; Preoptic Area; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Reward | 2013 |
A factor analysis of global GABAergic gene expression in human brain identifies specificity in response to chronic alcohol and cocaine exposure.
Topics: Adolescent; Adult; Alcoholics; Alcoholism; Cerebellum; Cocaine; Cocaine-Related Disorders; Ethanol; Factor Analysis, Statistical; Female; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; Humans; Male; Receptors, GABA-A; Young Adult | 2013 |
Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.
Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Rats; Rats, Wistar; Receptors, Opioid, kappa; Self Administration | 2013 |
D1 dopamine receptor-mediated LTP at GABA synapses encodes motivation to self-administer cocaine in rats.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Long-Term Potentiation; Male; Motivation; Neurotensin; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Reinforcement, Psychology; Self Administration; Septal Nuclei; Synapses | 2013 |
Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Synaptic Transmission; Ventral Tegmental Area | 2013 |
Repeated cocaine weakens GABA(B)-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex.
Topics: Animals; Behavior, Animal; Cocaine; Drug-Seeking Behavior; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neurons; Prefrontal Cortex; Pyramidal Cells; Receptors, Dopamine D1; Signal Transduction | 2013 |
Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms.
Topics: Action Potentials; Amphetamine; Animals; Cesium; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Feedback, Physiological; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Neurons; Pedunculopontine Tegmental Nucleus; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Synaptic Transmission; Ventral Tegmental Area | 2013 |
Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum.
Topics: Analgesics, Opioid; Animals; Cocaine; gamma-Aminobutyric Acid; Globus Pallidus; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission | 2014 |
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Basal Forebrain; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Phenethylamines; Purines; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reinforcement, Psychology; Reward; Self Administration; Triazoles | 2015 |
Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.
Topics: Action Potentials; Animals; Anxiety; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dorsal Raphe Nucleus; Exploratory Behavior; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Receptor, Serotonin, 5-HT2C; Serotonin Agents; Substance Withdrawal Syndrome; Time Factors; Tryptophan Hydroxylase | 2015 |
Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area.
Topics: Animals; Bicuculline; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine; Extracellular Fluid; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Male; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Ventral Tegmental Area | 2015 |
Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area.
Topics: Animals; Arachidonic Acids; Biological Transport; Calcium; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Endocannabinoids; gamma-Aminobutyric Acid; Gene Expression Regulation; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Male; Norepinephrine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-1; Receptors, GABA; Receptors, Metabotropic Glutamate; Reward; Synaptic Transmission; Type C Phospholipases; Ventral Tegmental Area | 2015 |
Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors.
Topics: Action Potentials; Animals; Cadmium Chloride; Caffeine; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Mice; Mice, Knockout; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin Agents; Thalamic Nuclei; Type C Phospholipases | 2016 |
Cocaine self-administration induces changes in synaptic transmission and plasticity in ventral hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CA1 Region, Hippocampal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Hippocampus; Long-Term Potentiation; Male; N-Methylaspartate; Neuronal Plasticity; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Self Administration; Synaptic Transmission | 2017 |
Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dorsal Raphe Nucleus; gamma-Aminobutyric Acid; Male; Neurons; Neuropeptides; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Signal Transduction | 2016 |
[Effects of 1,3-diphenyl-1,3-propanedione on neurotransmitter contents of brain in mice administered with cocaine].
Topics: Animals; Brain; Brain Chemistry; Cocaine; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Neurotransmitter Agents; Phenylenediamines; Serotonin | 2016 |
Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse.
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Male; Mesencephalon; Mice; Mice, Transgenic; Neural Pathways; Neurons; Recurrence; Synapses; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2016 |
Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.
Topics: Action Potentials; Animals; Arachidonic Acids; Cocaine; Conditioning, Classical; Dopaminergic Neurons; Endocannabinoids; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycerides; Hypothalamic Area, Lateral; Inhibitory Postsynaptic Potentials; Male; Mice, Inbred C57BL; Models, Biological; Neural Inhibition; Orexin Receptors; Orexins; Rats, Wistar; Receptor, Cannabinoid, CB1; Recurrence; Restraint, Physical; Signal Transduction; Stress, Physiological; Synaptic Transmission; Ventral Tegmental Area | 2016 |
Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats.
Topics: Animals; Benzoxazoles; Central Amygdaloid Nucleus; Cocaine; Drug-Seeking Behavior; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Stress, Psychological; Urea | 2017 |
Chronic cocaine exposure induces noradrenergic modulation of inhibitory synaptic transmission to cholinergic neurons of the laterodorsal tegmental nucleus.
Topics: Adrenergic alpha-Agonists; Animals; Cholinergic Neurons; Cocaine; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Glycine; Inhibitory Postsynaptic Potentials; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tegmentum Mesencephali | 2016 |
Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis.
Topics: Adaptation, Physiological; Aging; Animals; Behavior, Animal; Cocaine; Cognition Disorders; Dentate Gyrus; Emotions; Exploratory Behavior; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Memory Disorders; Mice, Inbred C57BL; Neurogenesis; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome | 2017 |
Acupuncture reduces relapse to cocaine-seeking behavior via activation of GABA neurons in the ventral tegmental area.
Topics: Acupuncture; Animals; Baclofen; Behavior, Animal; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophysiological Phenomena; GABA-B Receptor Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Locomotion; Microdialysis; Nucleus Accumbens; Rats; Ventral Tegmental Area | 2018 |
PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure.
Topics: Action Potentials; Animals; Cocaine; Cyclic Nucleotide Phosphodiesterases, Type 4; Dopamine; Dopamine Uptake Inhibitors; Female; gamma-Aminobutyric Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neural Inhibition; Neurons; Phosphodiesterase 4 Inhibitors; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rolipram; Tissue Culture Techniques; Ventral Tegmental Area | 2017 |
Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs).
Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopaminergic Neurons; Endocannabinoids; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Long-Term Synaptic Depression; Mice; Neuronal Plasticity; Neuroprotective Agents; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Resveratrol; Ventral Tegmental Area | 2017 |
N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse.
Topics: Animals; Cocaine; Comorbidity; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Knockout; Microdialysis; Nucleus Accumbens; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Self Stimulation; Serine; Substance-Related Disorders | 2019 |
c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo.
Topics: Animals; Autonomic Nervous System; Cocaine; Dopamine Uptake Inhibitors; Dopaminergic Neurons; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Reward; Substance Withdrawal Syndrome; Transcriptional Activation; Ventral Tegmental Area | 2018 |
Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cocaine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Synaptic Transmission; Ventral Tegmental Area | 2018 |
phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats.
Topics: Alcoholism; Amphetamine; Amygdala; Animals; Brain; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Functional Neuroimaging; gamma-Aminobutyric Acid; Glutamic Acid; Locomotion; Magnetic Resonance Imaging; Microdialysis; Nucleus Accumbens; Rats; Self Administration | 2019 |
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization.
Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopaminergic Neurons; gamma-Aminobutyric Acid; Glutamic Acid; Male; Models, Biological; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; Ventral Tegmental Area | 2020 |
Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Estradiol; Female; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; Motor Activity; Ovariectomy; Prefrontal Cortex; Rats; Rats, Wistar; Taurine | 2020 |
GABAergic projections to the ventral tegmental area govern cocaine-conditioned reward.
Topics: Animals; Cocaine; Conditioning, Psychological; Dopamine; Dopaminergic Neurons; GABAergic Neurons; gamma-Aminobutyric Acid; Nucleus Accumbens; Optogenetics; Rats; Reward; Ventral Tegmental Area | 2021 |
Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats.
Topics: Animals; Central Nervous System Stimulants; Cocaine; gamma-Aminobutyric Acid; Male; Motivation; Neuropeptides; Nucleus Accumbens; Rats; Self Medication | 2022 |
Neuromedin U: a neuropeptide modulator of GABA transmission contributes to cocaine seeking.
Topics: Cocaine; gamma-Aminobutyric Acid; Neuropeptides; Self Administration | 2022 |
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Mice; Narcotic Antagonists; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; RNA, Messenger | 2022 |
Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA.
Topics: Animals; Astrocytes; Cocaine; Dopaminergic Neurons; gamma-Aminobutyric Acid; Membrane Proteins; Mice; Receptors, GABA-A; Reward; Ventral Tegmental Area | 2023 |
Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward.
Topics: Astrocytes; Cocaine; gamma-Aminobutyric Acid; Reward; Synaptic Transmission | 2024 |
α4-Containing GABA
Topics: Animals; Cocaine; gamma-Aminobutyric Acid; Mice; Mice, Knockout; Neurons; Nucleus Accumbens; Receptors, Dopamine D2; Receptors, GABA-A | 2023 |