cocaine has been researched along with fluoxetine in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (4.30) | 18.7374 |
| 1990's | 73 (39.25) | 18.2507 |
| 2000's | 84 (45.16) | 29.6817 |
| 2010's | 21 (11.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sen, S; Sinha, N | 1 |
| Deschaux, O; Flippen-Anderson, JL; Johnson, KM; Kozikowski, AP; Tamiz, AP; Tella, S; Zhang, J; Zhang, M | 1 |
| Hoepping, A; Johnson, KM; Kozikowski, AP; Mukhopadhyaya, J; Zhang, A; Zhang, M; Zhou, G | 1 |
| Keserü, GM | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Jia, L; Sun, H | 1 |
| Cashman, JR; Janowsky, A; Johnson, R; Voelker, T | 1 |
| Cashman, JR; Fandrick, K; Janowsky, A; Johnson, R; Voelker, T; Xia, H | 1 |
| Cashman, JR; O'Donnell, JM; Voelker, T; Zhang, HT | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Arunotayanun, W; Dalley, JW; Gibbons, S; Huang, XP; Iversen, L; Roth, BL; Setola, V; Treble, R | 1 |
| Brooke, D; Fudala, PJ; Johnson, RE | 1 |
| Azmitia, EC; Berger, UV; Gu, XF | 1 |
| Anestis, DK; Gruetter, CA; Lemke, SM; Szarek, JL; Valentovic, MA | 1 |
| Chelonis, JJ; Geary, N; Logue, AW; Schachter, S; Tobin, H; Wang, RY | 1 |
| Cunningham, KA; Goeders, NE; Paris, JM | 1 |
| Byrd, LD; Howell, LL | 1 |
| Nelson, JC | 1 |
| Cox, BM; Izenwasser, S; Jacocks, HM; Werling, LL | 1 |
| Callahan, PM; Cunningham, KA | 2 |
| Gale, K; Meloni, R | 1 |
| Richardson, NR; Roberts, DC | 1 |
| Batki, SL; Dumontet, R; Jacob, P; Jones, RT; Manfredi, LB; Sorensen, JL | 1 |
| Brown, BS; Haertzen, CA; Hess, JM; Weddington, WW | 1 |
| Pollack, MH; Rosenbaum, JF | 1 |
| Cox, BM; Izenwasser, S; Werling, LL | 1 |
| Asencio, M; Carroll, ME; Kragh, R; Lac, ST | 1 |
| Gonzales, RA; Moerschbaecher, JM; Mosaddeghi, M | 1 |
| Goldberg, SR; Goodman, NL; Kuhar, MJ; Porrino, LJ; Ritz, MC; Sharpe, LG | 1 |
| Woolverton, WL | 1 |
| Goldberg, LI; Kamien, JB; Woolverton, WL | 1 |
| Monroe, PJ; Smith, DJ | 1 |
| Snoddy, AM; Tessel, RE | 1 |
| Kawasaki, H; Takasaki, K | 1 |
| Appel, JB; White, FJ | 1 |
| Covi, L; Haertzen, CA; Hess, JM; Kreiter, NA | 1 |
| Creson, D; Davis, C; Elk, R; Grabowski, J; Kirby, K; Rhoades, H; Schmitz, J | 1 |
| Tella, SR | 1 |
| Gard, PR; Mandy, A; Meakin, AJ; Nickels, DP; Whiting, JM | 1 |
| Bäck, N; Kaartinen, K; Soinila, S; Vanhatalo, S | 1 |
| Carroll, K; Cushing, G; Gordon, L; Petrakis, I; Rounsaville, B | 1 |
| Dewey, SL; Fowler, JS; Gatley, SJ; King, P; Logan, J; MacGregor, RR; Pappas, N; Schlyer, DJ; Volkow, ND; wang, GJ | 1 |
| Balon, R | 1 |
| Alexoff, DA; Chen, R; Dewey, SL; Ding, YS; Fowler, JS; Gatley, SJ; Pan, D | 1 |
| Peltier, R; Schenk, S | 1 |
| Goldberg, SR; Tella, SR | 1 |
| Bigelow, GE; Fromme, R; Preston, KL; Sullivan, JT; Walsh, SL | 1 |
| Chen, NH; Reith, ME | 2 |
| Katz, JL; Terry, P; Witkin, JM | 1 |
| Cline, EJ; Kim, S; Kuhar, MJ; Scheffel, U | 1 |
| Baker, G; McGregor, A; Roberts, DC | 1 |
| Bayer, BM; Berkeley, MB; Daussin, S; Hernandez, MC | 1 |
| Ganapathy, V; Jayanthi, LD; Leibach, FH; Mahesh, VB; Prasad, PD; Ramamoorthy, S | 1 |
| Boja, JW; Brouard, A; Carroll, FI; Kuhar, MJ; Pelaprat, D; Rostene, W; Vial, M | 1 |
| Cheng, CH; Costall, B; Naylor, RJ; Rudd, JA | 1 |
| Goldberg, SR; Schindler, CW; Tella, SR | 1 |
| Henry, DJ; Hu, XT; White, FJ | 1 |
| Batki, SL; Jacob, P; Jones, RT; Manfredi, LB | 1 |
| Kleven, MS; Woolverton, WL | 1 |
| Dow-Edwards, DL; Frick, GS | 1 |
| Childers, SR; Davies, HM; Kuhn, LA; Matasi, JJ; Sexton, T; Thornley, C | 1 |
| Gallagher, JP; Simms, D | 1 |
| Batki, SL; Delucchi, K; Jones, RT; Washburn, AM | 1 |
| Abraham, P; Blough, BE; Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH | 1 |
| Darmani, NA | 2 |
| Abraham, P; Boja, JW; Carroll, FI; Holmquist, CR; Keverline-Frantz, KI; Kuhar, MJ | 1 |
| Bekavac, I; Gould, EM; Waterhouse, BD | 1 |
| Barros, HM; Belej, T; Manji, D; Nobrega, JN; Sioutis, S | 1 |
| Darmani, NA; Reeves, SL | 1 |
| Grilly, DM; Pistell, PJ | 1 |
| Francis, R; Kuhn, C | 1 |
| Budney, AJ; Higgins, ST | 1 |
| Davies, HM; Hedgecock, AA; Matasi, JJ; Miller, M; Porrino, LJ; Thornley, C | 1 |
| Daunais, JB; Davies, HM; Hart, SL; Hedgecock-Rowe, A; Matasi, JJ; Porrino, LJ; Thornley, C | 1 |
| Avor, K; Basmadjian, GP; Chan, HM; Hall, N; Seale, TW; Singh, S | 1 |
| Kleven, MS; Koek, W | 1 |
| Herges, S; Taylor, DA | 2 |
| Cornelius, JR; Daley, DC; Haskett, RF; Jones-Barlock, A; Perel, JM; Salloum, IM; Thase, ME; Upsher, C | 1 |
| Carroll, KM; Gordon, L; Kosten, T; Nich, C; Petrakis, I; Rounsaville, B | 1 |
| McReynolds, AM; Meyer, JS | 1 |
| Chen, N; Justice, JB; Trowbridge, CG | 1 |
| Aunis, D; Burgun, C; Humblot, N; Thiriet, N; Zwiller, J | 1 |
| Holtzman, SG; Waddell, AB | 1 |
| Blakely, RD; Jansen, K; Richelson, E; Tatsumi, M | 1 |
| Carmolli, M; Cumbay, M; Eshleman, AJ; Janowsky, A; Martens, CR; Neve, KA | 1 |
| Berthold, F; Bönisch, H; Hadrich, D; Steckhan, E | 1 |
| Carroll, FI; French, D; Izenwasser, S; Kunko, PM | 1 |
| Borda, E; Busch, L; Sterin-Borda, L; Wald, M | 1 |
| Meyer, JS; Shearman, LP | 1 |
| Blundell, P; Gonzalez, MD; Liang, AY; Madras, BK; Meltzer, PC; Niznik, HB; Pristupa, ZB | 1 |
| Izenwasser, S; Katz, JL; Terry, P | 1 |
| Carroll, FI; Kimmel, HL; Kuhar, MJ | 1 |
| Duman, RS; Impey, S; Sakai, N; Shin, K; Steffen, C; Storm, D; Thome, J; Zhang, YJ | 1 |
| Borda, E; Busch, L; Wald, M | 1 |
| Li, J; Ordway, GA; Shamburger, S; Zhu, MY | 1 |
| Brodde, OE; Leineweber, K; Seyfarth, T | 1 |
| Deslandes, PN; Pache, DM; Sewell, RD; Subhan, F | 1 |
| Baker, DA; Fuchs, RA; Neisewander, JL; Tran-Nguyen, TL | 1 |
| Baek, D; Bergstrom, DA; Freeman, LE; Ruskin, DN; Walters, JR | 1 |
| Breitinger, HG; Geetha, N; Hess, GP | 1 |
| Hori, M; Kato, B; Kawano, H; Noritake, K; Sakai, K; Shibata, M; Takeuchi, Y; Ueda, S; Wakabayashi, Y; Yasuhara, M; Yoshimoto, K | 1 |
| Garland, T; Girard, I; Hosack, GR; Kelley, AE; Mitchell, GS; Rhodes, JS | 1 |
| Bryan-Lluka, LJ; Paczkowski, FA | 1 |
| Brockington, A; Hope, BT; Morón, JA; Rocha, BA; Wise, RA | 1 |
| Yan, QS | 1 |
| Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA | 1 |
| Batki, SL; Delucchi, KL; Jacob, P; Jones, RT; Moon, J | 1 |
| DeFelice, LJ; Jayanthi, LD; Vargas, G | 1 |
| Budygin, EA; John, CE; Jones, SR; Mateo, Y | 2 |
| Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA; Runkel, F; Sucic, S | 1 |
| Connor, DF; DeLeon, KR; Grimes, JM; Melloni, RH | 1 |
| Gill, SS; Ross, LS; Sandhu, SK | 1 |
| Caron, M; Hall, FS; Lesch, KP; Li, XF; Murphy, DL; Sora, I; Uhl, GR; Xu, F | 1 |
| Bryan-Lluka, LJ; Sucic, S | 2 |
| Bolaños, CA; Cohen, OS; Jackson, D; Trksak, GH | 1 |
| Macey, DJ; Nader, MA; Porrino, LJ; Smith, HR | 1 |
| Burmeister, JJ; Lungren, EM; Neisewander, JL | 1 |
| Bubar, MJ; Cunningham, KA; De Deurwaerdère, P; McMahon, LR; Spampinato, U | 1 |
| Cleary, L; Docherty, JR | 1 |
| Quick, MW | 1 |
| Baker, GB; Fletcher, PJ; Salsali, M; Sinyard, J | 1 |
| Candeletti, S; Collins, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P | 1 |
| Caboche, J; Girault, JA; Hervé, D; Pagès, C; Valjent, E | 1 |
| Hagino, Y; Hall, FS; Ikeda, K; Kobayashi, H; Lesch, KP; Murphy, DL; Shen, HW; Shinohara-Tanaka, K; Sora, I; Uhl, GR; Yamamoto, H; Yamamoto, T | 1 |
| Steketee, JD; Williams, JM | 1 |
| Candeletti, S; D'Addario, C; Di Benedetto, M; Feliciani, D; Izenwasser, S; Romualdi, P | 1 |
| Anand, A; Baldwin, RM; Bozkurt, A; Charney, D; Innis, RB; Khan, S; Kugaya, A; Malison, RT; Sanacora, G; Seibyl, JP; Staley, JK; Van Dyck, CH | 1 |
| Hanania, T; Lyons, AM; McCreary, AC; Salaz, DO; Zahniser, NR | 1 |
| Augsburger, M; Cardinal, P; Eap, C; Giroud, C; Mangin, P; Michaud, K; Sporkert, F | 1 |
| Banks, ML; Budygin, EA; John, CE; Jones, SR; Mateo, Y | 1 |
| Beveridge, TJ; Nader, MA; Porrino, LJ; Smith, HR | 2 |
| Mash, DC; Ouyang, Q; Pablo, J; Qin, Y | 1 |
| Dutta, AK; Reith, ME; Wang, LC | 1 |
| Herndon, JG; Killiany, RJ; Luebke, JI; Moore, TL; Moss, MB; Rosene, DL; Schettler, SP | 1 |
| Ahmed, R; Akhisaroglu, M; Dirim Arslan, A; Imbesi, M; Kurtuncu, M; Manev, H; Uz, T | 1 |
| Swant, J; Thompson, AM; Wagner, JJ | 1 |
| Grundt, P; Katz, JL; Kopajtic, TA; Newman, AH | 1 |
| Adkins, EM; Blakely, RD; Field, JR; Henry, LK; Newman, AH; Parnas, ML; Vaughan, RA; Zou, MF | 1 |
| Fukushima, S; Hall, FS; Kobayashi, H; Numachi, Y; Shen, HW; Sora, I; Uhl, GR; Yamashita, M | 1 |
| Manev, H; Uz, T | 1 |
| Beard, JL; Burhans, MS; Dailey, C; Jones, BC; Murray-Kolb, LE; Wiesinger, J | 1 |
| Anglard, P; Aunis, D; Burgun, C; Carouge, D; Cassel, S; Dietrich, JB; Gensburger, C; Zwiller, J | 1 |
| Linazasoro, G; Van Blercom, N | 1 |
| Candeletti, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P | 1 |
| Carroll, FI; Goodman, MM; Howell, LL; Kimmel, HL; Votaw, JR | 1 |
| Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
| Deutsch, HM; Kim, DI; Schweri, MM; Ye, X | 1 |
| Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Blakely, RD; Deecher, DC; Mahaney, PE; Mason, JN; Richmond, RL; Stack, G; Trybulski, E; Winneker, RC | 1 |
| Beaudin, SA; Booze, RM; Ferris, MJ; Hasselrot, U; Mactutus, CF; Silvers, JM; Strupp, BJ | 1 |
| Hnasko, TS; Palmiter, RD; Sotak, BN | 1 |
| Dudczak, R; Ettlinger, DE; Girschele, F; Häusler, D; Kletter, K; Mien, LK; Mitterhauser, M; Sindelar, KM; Ungersböck, J; Viernstein, H; Wadsak, W | 1 |
| Katz, JL; Soto, PL | 1 |
| Gulley, JM; Klein, DA | 1 |
| Kritzer, MF; Meyers, B | 1 |
| Hall, FS; Jones, JD; Rice, K; Riley, AL; Uhl, GR | 1 |
| Borue, X; Condron, B; Cooper, S; Hirsh, J; Venton, BJ | 1 |
| Forrest, LR; Rudnick, G; Tavoulari, S | 1 |
| Condron, B; Venton, BJ; Vickrey, TL | 1 |
| Cho, T; Lee, C; Min, CK; Yoon, SH; Yoon, YS | 1 |
| Cheng, FC; Feng, JJ; Lin, CH; Wei, JW; Yang, SD | 1 |
| Oleson, EB; Richardson, JM; Roberts, DC | 1 |
| Desai, A; Fraser, R; Gnegy, ME; Guptaroy, B; Zhang, M | 1 |
| Fisar, Z; Hroudová, J; Raboch, J | 1 |
| Ali, S; Dutta, AK; Reith, ME; Zhen, J | 1 |
| Pan, CH; Tsai, S | 1 |
| Goodman, MM; Howell, LL; Kimmel, HL; Mun, J; Nye, JA; Rice, KC; Sawyer, EK; Stehouwer, JS; Voll, RJ | 1 |
| Beverley, J; Steiner, H; Van Waes, V; Vandrevala, M | 1 |
| Gouda, H; Handa, K; Hirono, S; Nakagome, I; Yamaotsu, N | 1 |
| Achterberg, EJ; Schoffelmeer, AN; Schrama, L; Siviy, SM; Trezza, V; Vanderschuren, LJ | 1 |
| Heilbronner, SR; Meck, WH | 1 |
| Alcantara, LF; Bolaños-Guzmán, CA; Iñiguez, SD; Parise, EM; Warren, BL | 1 |
| Chen, HX; Gao, N; Jin, ZL; Li, XR; Li, YF; Tang, Y; Xiong, J; Zhang, JR | 1 |
| Platt, DM; Rüedi-Bettschen, D; Spealman, RD | 1 |
| Cruz, B; Iñiguez, SD; Mazei-Robison, MS; Nieto, SJ; Riggs, LM; Robison, AJ; Wright, KN; Zamora, NN; Zavala, AR | 1 |
| Hales, CA; Houghton, CJ; Robinson, ESJ | 1 |
| Blakely, RD; Carroll, FI; Davis, GL; Gowrishankar, R; Gresch, PJ; Hahn, MK; Katamish, RM; Peart, R; Rabil, MJ; Stewart, A | 1 |
1 review(s) available for cocaine and fluoxetine
| Article | Year |
|---|---|
From the initial clinic contact to aftercare: a brief review of effective strategies for retaining cocaine abusers in treatment.
Topics: Antidepressive Agents; Appointments and Schedules; Clinical Trials as Topic; Cocaine; Desipramine; Fluoxetine; Humans; Patient Compliance; Psychotherapy; Social Support; Substance-Related Disorders; Treatment Outcome | 1997 |
12 trial(s) available for cocaine and fluoxetine
| Article | Year |
|---|---|
Weighing up the pros and cons: help-seeking by drug misusers in Baltimore, USA.
Topics: Adult; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Fear; Female; Fluoxetine; Humans; Male; Methadone; Middle Aged; Motivation; Opioid-Related Disorders; Patient Acceptance of Health Care; Phencyclidine Abuse; Substance Abuse Treatment Centers; Substance-Related Disorders; Urban Population | 1992 |
Psychological reactions and retention by cocaine addicts during treatment according to HIV-serostatus: a matched-control study.
Topics: Adaptation, Psychological; Adult; Affect; AIDS Serodiagnosis; Amantadine; Baltimore; Cocaine; Combined Modality Therapy; Desipramine; Female; Fluoxetine; HIV Seropositivity; Humans; Male; Patient Dropouts; Psychotherapy; Sick Role; Substance-Related Disorders | 1991 |
Effects of combined fluoxetine and counseling in the outpatient treatment of cocaine abusers.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Cocaine; Combined Modality Therapy; Counseling; Diphenhydramine; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Hypnotics and Sedatives; Male; Middle Aged; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Fluoxetine is ineffective for treatment of cocaine dependence or concurrent opiate and cocaine dependence: two placebo-controlled double-blind trials.
Topics: Adult; Cocaine; Demography; Double-Blind Method; Female; Fluoxetine; Humans; Male; Methadone; Opioid-Related Disorders; Psychiatric Status Rating Scales | 1995 |
Fluoxetine alters the effects of intravenous cocaine in humans.
Topics: Adult; Affect; Arousal; Blood Pressure; Cocaine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fluoxetine; Heart Rate; Humans; Male; Substance Abuse, Intravenous; Substance-Related Disorders | 1994 |
Fluoxetine for cocaine dependence in methadone maintenance: quantitative plasma and urine cocaine/benzoylecgonine concentrations.
Topics: Adult; Cocaine; Female; Fluoxetine; Humans; Male; Methadone; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Substance-Related Disorders | 1993 |
A controlled trial of fluoxetine in crack cocaine dependence.
Topics: Adult; Ambulatory Care; Cocaine; Crack Cocaine; Double-Blind Method; Female; Fluoxetine; Humans; Male; Opioid-Related Disorders; Selective Serotonin Reuptake Inhibitors; Substance Abuse Detection; Treatment Outcome | 1996 |
Fluoxetine versus placebo in depressed alcoholic cocaine abusers.
Topics: Adult; Alcoholism; Antidepressive Agents, Second-Generation; Cocaine; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male; Narcotics; Psychiatric Status Rating Scales; Substance-Related Disorders | 1998 |
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts.
Topics: Adult; Antidepressive Agents, Second-Generation; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Depression; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Heroin; Humans; Male; Methadone; Narcotics; Opioid-Related Disorders; Substance Abuse Detection; Treatment Outcome | 1998 |
Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior.
Topics: Animals; Animals, Outbred Strains; Breeding; Cocaine; Crosses, Genetic; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Fluoxetine; Hyperkinesis; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Piperazines | 2001 |
Urine toxicology samples in cocaine treatment trials: how many need to be tested?
Topics: Adult; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; Fluoxetine; Humans; Male; Predictive Value of Tests; Substance Abuse Detection | 2002 |
Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors.
Topics: Adult; Analysis of Variance; Brain Mapping; Cocaine; Depressive Disorder, Major; Diencephalon; Female; Fluoxetine; Humans; Iodine Radioisotopes; Male; Matched-Pair Analysis; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Paroxetine; Radiopharmaceuticals; Reference Values; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2004 |
173 other study(ies) available for cocaine and fluoxetine
| Article | Year |
|---|---|
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Motor Activity; Nerve Endings; Nerve Tissue Proteins; Norepinephrine; Piperidines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship | 2000 |
Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transpo
Topics: Animals; Brain; Bridged-Ring Compounds; Carrier Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Conformation; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters; Synaptosomes; Tropanes | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.
Topics: Antidepressive Agents; Cross-Linking Reagents; Drug Delivery Systems; Drug Synergism; Humans; Inhibitory Concentration 50; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 2009 |
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
Topics: Animals; Antidepressive Agents; Cocaine; Dopamine; Furans; Mice; Mice, Inbred BALB C; Norepinephrine Plasma Membrane Transport Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming | 2009 |
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Mice; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Rats; Selective Serotonin Reuptake Inhibitors | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Topics: Allyl Compounds; HEK293 Cells; Humans; Indoles; Magnetic Resonance Spectroscopy; Molecular Conformation; Propylamines; Protein Binding; Psychotropic Drugs; Receptors, Serotonin; Serotonin Receptor Agonists; Spectrophotometry, Ultraviolet; Tryptamines | 2013 |
The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Calcium; Cocaine; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; p-Chloroamphetamine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synaptosomes | 1992 |
Potentiation of 5-hydroxytryptamine-induced contraction in rat aorta by chlorpheniramine, citalopram and fluoxetine.
Topics: Animals; Aorta, Thoracic; Chlorpheniramine; Citalopram; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Histamine H1 Antagonists; Imipramine; In Vitro Techniques; Male; Pargyline; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction | 1992 |
Cocaine decreases self-control in rats: a preliminary report.
Topics: Animals; Cocaine; Conditioning, Operant; Fluoxetine; Injections, Intraperitoneal; Male; Rats; Reinforcement, Psychology | 1992 |
Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Behavior, Animal; Brain; Brain Chemistry; Cocaine; Electrophysiology; Fluoxetine; Male; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes | 1992 |
Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Infusion Pumps; Male; Quipazine; Receptors, Dopamine; Receptors, Dopamine D2; Saimiri; Spiperone | 1992 |
Current status of tricyclic antidepressants in psychiatry: their pharmacology and clinical applications.
Topics: Aged; Antidepressive Agents, Tricyclic; Anxiety Disorders; Cocaine; Depressive Disorder; Feeding and Eating Disorders; Fluoxetine; Humans; Panic; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Comparison of dopamine uptake and release in vitro in sheep and rat striatum.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Female; Fluoxetine; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sheep | 1991 |
Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat.
Topics: Animals; Cocaine; Desipramine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluoxetine; Male; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains | 1991 |
Cocaine-induced turning behavior in rats with 6-hydroxydopamine lesions: effect of transplants of fetal substantia nigra.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Diseases; Brain Tissue Transplantation; Cocaine; Dopamine; Fetal Tissue Transplantation; Fluoxetine; Imipramine; Male; Neural Pathways; Neurotransmitter Uptake Inhibitors; Nomifensine; Oxidopamine; Piperazines; Rats; Rats, Inbred Strains; Substantia Nigra | 1991 |
Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat.
Topics: Animals; Cocaine; Drug Administration Schedule; Fluoxetine; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Self Medication; Serotonin | 1991 |
Fluoxetine for cocaine abuse in methadone patients: preliminary findings.
Topics: Adult; Cocaine; Female; Fluoxetine; Heroin Dependence; Humans; Male; Methadone; Substance-Related Disorders | 1990 |
Fluoxetine treatment of cocaine abuse in heroin addicts.
Topics: Adult; Cocaine; Female; Fluoxetine; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Substance Abuse, Intravenous; Substance-Related Disorders | 1991 |
Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluoxetine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Nalidixic Acid; Naphthyridines; Neurotransmitter Uptake Inhibitors; Norepinephrine; Nucleus Accumbens; Olfactory Bulb; Piperazines; Rats; Rats, Inbred Strains | 1990 |
Fluoxetine reduces intravenous cocaine self-administration in rats.
Topics: Animals; Cocaine; Drinking Behavior; Feeding Behavior; Fluoxetine; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Self Administration | 1990 |
Effect of monoamine uptake inhibitors on norepinephrine-stimulated phosphatidylinositol hydrolysis in rat cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Desipramine; Fluoxetine; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phosphatidylinositols; Prazosin; Rats; Receptors, Adrenergic, alpha | 1989 |
Differential effects of the pharmacological manipulation of serotonin systems on cocaine and amphetamine self-administration in rats.
Topics: Amphetamine; Animals; Cinanserin; Cinnamates; Cocaine; Fluoxetine; Male; Rats; Rats, Inbred Strains; Reinforcement Schedule; Self Administration; Serotonin | 1989 |
Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys.
Topics: Animals; Cocaine; Female; Fluoxetine; Macaca mulatta; Male; Norepinephrine; Prazosin; Psychomotor Performance; Reinforcement, Psychology; Self Administration | 1987 |
Pharmacological analysis of the apomorphine discriminative stimulus in rhesus monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Cocaine; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Domperidone; Dose-Response Relationship, Drug; Female; Fluoxetine; Macaca mulatta; Male; Physostigmine; Piribedil; Quipazine; Sodium Chloride | 1987 |
Demonstration of an autoreceptor modulating the release of [3H]5-hydroxytryptamine from a synaptosomal-rich spinal cord tissue preparation.
Topics: Animals; Cocaine; Desipramine; Fluoxetine; Lysergic Acid Diethylamide; Male; Norepinephrine; Pargyline; Potassium; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spinal Cord; Synaptosomes | 1985 |
Prazosin: effect on psychomotor-stimulant cues and locomotor activity in mice.
Topics: Amphetamine; Animals; Cocaine; Cues; Discrimination, Psychological; Fluoxetine; Male; Mice; Mice, Inbred ICR; Motor Activity; Pimozide; Prazosin; Propranolol; Stereotyped Behavior | 1985 |
Vasoconstrictor response induced by 5-hydroxytryptamine released from vascular adrenergic nerves by periarterial nerve stimulation.
Topics: Animals; Blood Pressure; Cocaine; Electric Stimulation; Fluoxetine; Hydroxydopamines; Male; Muscle, Smooth, Vascular; Norepinephrine; Oxidopamine; Phentolamine; Rats; Rats, Inbred Strains; Serotonin; Sympathetic Nervous System; Vasoconstriction | 1984 |
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine.
Topics: Animals; Cocaine; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hallucinogens; Lisuride; Lysergic Acid Diethylamide; Male; p-Chloroamphetamine; Piperazines; Pyrazines; Quipazine; Rats; Serotonin; Serotonin Antagonists | 1981 |
Effects of monoamine reuptake inhibitors on cocaine self-administration in rats.
Topics: Animals; Biogenic Monoamines; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intravenous; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Reward; Self Administration | 1995 |
Reduction of responses to angiotensin II by antidepressant drugs.
Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Animals; Antidepressive Agents; Binding, Competitive; Cocaine; Desipramine; Drinking; Drug Interactions; Female; Fluoxetine; In Vitro Techniques; Isoproterenol; Male; Oxytocin; Rats; Rats, Wistar; Tranylcypromine; Uterine Contraction; Uterus | 1994 |
Colocalization of dopamine and serotonin in the rat pituitary gland and in the nuclei innervating it.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Cocaine; Dopamine; Female; Fluoxetine; Immunochemistry; Male; Pituitary Gland; Rats; Rats, Wistar; Serotonin | 1995 |
Fluoxetine treatment for dually diagnosed methadone maintained opioid addicts: a pilot study.
Topics: Adult; Cocaine; Combined Modality Therapy; Comorbidity; Depressive Disorder; Diagnosis, Dual (Psychiatry); Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Methadone; Opioid-Related Disorders; Patient Compliance; Personality Inventory; Psychotherapy; Substance Abuse Detection; Substance-Related Disorders | 1994 |
Carbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study.
Topics: Animals; Binding Sites; Brain; Carbon Radioisotopes; Carrier Proteins; Cerebellum; Citalopram; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Papio; Serotonin; Tomography, Emission-Computed | 1995 |
Fluoxetine for cocaine dependence in methadone maintenance.
Topics: Alcoholism; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Fluoxetine; Heroin Dependence; Humans; Methadone; Substance Abuse Detection; Substance-Related Disorders | 1994 |
Binding of bromine-substituted analogs of methylphenidate to monoamine transporters.
Topics: Animals; Binding, Competitive; Bromine; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Microdialysis; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Tomography, Emission-Computed, Single-Photon | 1994 |
Effects of serotonergic manipulations on cocaine self-administration in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reinforcement Schedule; Self Administration; Serotonin; Serotonin Receptor Agonists | 1993 |
Monoamine uptake inhibitors alter cocaine pharmacokinetics.
Topics: Animals; Biotransformation; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Interactions; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley | 1993 |
Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships.
Topics: Animals; Biogenic Monoamines; Citalopram; Cocaine; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Lidocaine; Ligands; Male; Microdialysis; Movement; Norepinephrine; Piperazines; Rats; Serotonin; Tetrodotoxin; Ventral Tegmental Area | 1994 |
Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine.
Topics: Animals; Cocaine; Discrimination Learning; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Rats; Rats, Sprague-Dawley | 1994 |
Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125I]RTI-55.
Topics: 1-Naphthylamine; Animals; Binding, Competitive; Brain Chemistry; Carrier Proteins; Cocaine; Fluoxetine; Hypothalamus; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Sertraline | 1994 |
Effect of 6-hydroxydopamine lesions of the amygdala on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; Amygdala; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Brain; Chlordiazepoxide; Cocaine; Desipramine; Dopamine; Estrus; Female; Fluoxetine; Ibotenic Acid; Injections, Intravenous; Male; Organ Specificity; Oxidopamine; Rats; Rats, Wistar; Self Administration; Time Factors; Tryptophan | 1994 |
In vitro effects of cocaine, lidocaine and monoamine uptake inhibitors on lymphocyte proliferative responses.
Topics: Animals; B-Lymphocytes; Cells, Cultured; Cocaine; Desipramine; Fluoxetine; Lidocaine; Lymphocyte Activation; Male; Mitogens; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Sprague-Dawley; Spleen; T-Lymphocytes | 1994 |
Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter.
Topics: Binding Sites; Carrier Proteins; Chlorides; Cocaine; Fluoxetine; Humans; In Vitro Techniques; Kinetics; Microvilli; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Placenta; Sodium; Symporters | 1993 |
Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.
Topics: Animals; Binding Sites; Binding, Competitive; Biological Transport; Cell Membrane; Cells, Cultured; Cocaine; Desipramine; Dopamine; Embryo, Mammalian; Fluoxetine; Iodine Radioisotopes; Kinetics; Mesencephalon; Neurons; Nomifensine; Rats; Rats, Wistar; Stereoisomerism; Tritium | 1993 |
The effect of 5-HT receptor ligands on the uptake of [3H]5-hydroxytryptamine into rat cortical synaptosomes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Cocaine; Desipramine; Female; Fluoxetine; In Vitro Techniques; Indoles; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptosomes; Tropisetron | 1993 |
Cocaine: cardiovascular effects in relation to inhibition of peripheral neuronal monoamine uptake and central stimulation of the sympathoadrenal system.
Topics: Adrenal Medulla; Animals; Biological Transport; Blood Pressure; Catecholamines; Chlorisondamine; Cocaine; Desipramine; Fluoxetine; Heart Rate; Male; Norepinephrine; Oxidopamine; Peripheral Nervous System; Propanolamines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors | 1993 |
[3H]dopamine and [3H]serotonin release in vitro induced by electrical stimulation in A9 and A10 dopamine regions of rat brain: characterization and responsiveness to cocaine.
Topics: Animals; Brain; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Fluoxetine; Male; Mesencephalon; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Synaptic Transmission | 1993 |
Electrophysiological effects of cocaine in the rat nucleus accumbens: microiontophoretic studies.
Topics: alpha-Methyltyrosine; Animals; Cocaine; Dopamine; Fenclonine; Fluoxetine; Iontophoresis; Male; Methyltyrosines; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Serotonin | 1993 |
Effects of three monoamine uptake inhibitors on behavior maintained by cocaine or food presentation in rhesus monkeys.
Topics: 1-Naphthylamine; Animals; Appetitive Behavior; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Macaca mulatta; Mazindol; Motivation; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors; Self Administration; Sertraline | 1993 |
The effects of cocaine on cerebral metabolic function in periweanling rats: the roles of serotonergic and dopaminergic uptake blockade.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Male; Pharmaceutical Vehicles; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Weaning | 1995 |
Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Frontal Lobe; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters; Tropanes | 1996 |
Modification of serotonin responses in rat dorsolateral septal nucleus neurons by acute and chronic cocaine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Male; Neurons; Rats; Rats, Sprague-Dawley; Septal Nuclei; Serotonin | 1996 |
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine; Nortropanes; Paroxetine; Radioligand Assay; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Structure-Activity Relationship; Tropanes | 1996 |
Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline.
Topics: 1-Naphthylamine; Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Head Movements; Male; Mice; Mice, Inbred ICR; Norepinephrine; Piperazines; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline; Tryptophan | 1996 |
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Serotonin; Stereoisomerism; Structure-Activity Relationship | 1996 |
Monoaminergic substrates underlying cocaine-induced enhancement of somatosensory-evoked discharges in rat barrel field cortical neurons.
Topics: Animals; Cocaine; Desipramine; Dopamine; Fluoxetine; Male; Norepinephrine; Piperazines; Rats; Serotonin; Somatosensory Cortex | 1996 |
Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects.
Topics: Administration, Oral; Animals; Autoradiography; Biological Transport; Brain; Carrier Proteins; Cocaine; Drug Administration Schedule; Female; Fluoxetine; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Substance Withdrawal Syndrome; Substance-Related Disorders; Symporters; Time Factors; Tritium | 1996 |
The stimulatory and inhibitory components of cocaine's actions on the 5-HTP-induced 5-HT2A receptor response.
Topics: 1-Naphthylamine; 5-Hydroxytryptophan; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Head Movements; Male; Mice; Mice, Inbred ICR; Norepinephrine; Piperazines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Fluoxetine alters the effects of cocaine on vigilance task performance of rats.
Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Arousal; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Fluoxetine; Logistic Models; Male; Narcotics; Rats; Rats, Inbred F344; Selective Serotonin Reuptake Inhibitors | 1997 |
Gender difference in cocaine-induced HPA axis activation.
Topics: Adrenocorticotropic Hormone; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Fluoxetine; Hypothalamo-Hypophyseal System; Male; Neurotransmitter Uptake Inhibitors; Orchiectomy; Ovariectomy; Piperazines; Pituitary-Adrenal System; Rats; Sex Characteristics; Time Factors | 1997 |
Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists.
Topics: Animals; Buspirone; Cocaine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluoxetine; Male; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1997 |
Local cerebral metabolic effects of the novel cocaine analog, WF-31: comparisons to fluoxetine.
Topics: Animals; Brain; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Glucose; Hippocampus; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1997 |
Alterations in behavior and opioid gene expression induced by the novel tropane analog WF-31.
Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Fluoxetine; Gene Expression; Genome; Male; Motor Activity; Protein Precursors; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tropanes | 1997 |
2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Symporters | 1997 |
Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
Topics: Animals; Cocaine; Desipramine; Discrimination Learning; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1998 |
Involvement of serotonin in the modulation of cocaine-induced locomotor activity in the rat.
Topics: Animals; Behavior, Animal; Cocaine; Drug Interactions; Female; Fluoxetine; Ketanserin; Methysergide; Motor Activity; Narcotics; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists | 1998 |
Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice.
Topics: 1-Naphthylamine; Animals; Behavior, Animal; Cocaine; Fenfluramine; Fluoxetine; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase Inhibitors; Piperazines; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline | 1998 |
Effects of prenatal cocaine exposure on serotonin and norepinephrine transporter density in the rat brain.
Topics: Aging; Animals; Brain; Carrier Proteins; Cocaine; Female; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reference Values; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 1998 |
Voltammetric studies on mechanisms of dopamine efflux in the presence of substrates and cocaine from cells expressing human norepinephrine transporter.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Carrier Proteins; Cocaine; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Fluoxetine; Humans; Ionophores; Kinetics; LLC-PK1 Cells; Membrane Potentials; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ouabain; Phenethylamines; Psychotropic Drugs; Swine; Symporters; Time Factors; Tyramine; Valinomycin; Veratridine | 1998 |
Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase.
Topics: 5,7-Dihydroxytryptamine; Amphetamine; Animals; Caffeine; Central Nervous System Stimulants; Cocaine; Drug Interactions; Dual-Specificity Phosphatases; Enzyme Induction; Fluoxetine; Genes, Immediate-Early; Immediate-Early Proteins; Male; Nerve Tissue Proteins; Protein Tyrosine Phosphatases; Rats; Rats, Wistar | 1998 |
Modulation of cocaine-induced motor activity in the rat by opioid receptor agonists.
Topics: Animals; Cisterna Magna; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections; Male; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors | 1998 |
Pharmacological profile of neuroleptics at human monoamine transporters.
Topics: Antipsychotic Agents; Carrier Proteins; Cell Line; Chlorpromazine; Cocaine; Dibenzazepines; Dibenzothiepins; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Pimozide; Piperazines; Protein Binding; Radioligand Assay; Recombinant Fusion Proteins; Serotonin Plasma Membrane Transport Proteins; Symporters; Thiazoles; Triflupromazine; Tritium | 1999 |
Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type.
Topics: Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Iodine Radioisotopes; Kidney; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pharmaceutical Preparations; Protein Binding; Radioligand Assay; Recombinant Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Symporters | 1999 |
Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents.
Topics: Carrier Proteins; Cocaine; Dihydropyridines; Fluorescent Dyes; Fluoxetine; Guanidines; Humans; Isoxazoles; Ligands; Neuroblastoma; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters; Tumor Cells, Cultured | 1999 |
Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity.
Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Dopamine Uptake Inhibitors; Drug Tolerance; Fluoxetine; Infusion Pumps, Implantable; Male; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Time Factors | 1999 |
Fluoxetine modulates norepinephrine contractile effect on rat vas deferens.
Topics: Animals; Calcium; Cocaine; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sodium Chloride; Vas Deferens | 2000 |
Cocaine up-regulates norepinephrine transporter binding in the rat placenta.
Topics: Animals; Body Weight; Brain Chemistry; Carrier Proteins; Cell Membrane; Cocaine; Eating; Female; Fluoxetine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Placenta; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Symporters; Up-Regulation | 1999 |
Nitrogen-based drugs are not essential for blockade of monoamine transporters.
Topics: Animals; Binding Sites; Carrier Proteins; Citalopram; Cocaine; COS Cells; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nitrogen; Norepinephrine; Putamen; Radioligand Assay | 1996 |
Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Nerve Tissue Proteins; Psychomotor Performance; Putamen; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tritium; Zimeldine | 2000 |
Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Injections, Intraventricular; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Symporters; Tropanes | 2000 |
cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; beta-Galactosidase; Brain Chemistry; Cocaine; Coloring Agents; Cyclic AMP Response Element-Binding Protein; Desipramine; Dopamine Uptake Inhibitors; Fluoxetine; Haloperidol; Lac Operon; Mice; Mice, Transgenic; Monoamine Oxidase Inhibitors; Phosphorylation; Transcription, Genetic; Tranylcypromine; Up-Regulation | 2000 |
Influence of castration on the response of the rat vas deferens to fluoxetine.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Castration; Cocaine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Male; Muscle Contraction; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Prazosin; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Testosterone; Vas Deferens | 2000 |
Regulation of the human norepinephrine transporter by cocaine and amphetamine.
Topics: Amphetamine; Animals; Carrier Proteins; Cells, Cultured; Cocaine; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Rats; RNA, Messenger; Symporters | 2000 |
Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat.
Topics: Animals; Behavior, Animal; Cocaine; Drug Synergism; Fluoxetine; Motor Activity; Nucleus Accumbens; Ondansetron; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Time Factors | 2000 |
Chamber-specific alterations of noradrenaline uptake (uptake(1)) in right ventricles of monocrotaline-treated rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Heart Failure; Heart Ventricles; Hypertrophy; In Vitro Techniques; Male; Membranes; Monocrotaline; Norepinephrine; Piperazines; Rats; Rats, Wistar; Tritium | 2000 |
Do antidepressants affect motivation in conditioned place preference?
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Cocaine; Conditioning, Psychological; Cyclobutanes; Cyclohexanols; Dose-Response Relationship, Drug; Fluoxetine; Male; Motivation; Norepinephrine; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Sertraline; Venlafaxine Hydrochloride | 2000 |
Influence of individual differences and chronic fluoxetine treatment on cocaine-seeking behavior in rats.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Extinction, Psychological; Fluoxetine; Individuality; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors | 2001 |
Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Animals; Biogenic Monoamines; Biological Clocks; Carrier Proteins; Cocaine; Desipramine; Dizocilpine Maleate; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fluoxetine; Globus Pallidus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Periodicity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 2001 |
Inhibition of the serotonin 5-HT3 receptor by nicotine, cocaine, and fluoxetine investigated by rapid chemical kinetic techniques.
Topics: Animals; Binding Sites; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Fluoxetine; Kinetics; Mice; Nicotine; Patch-Clamp Techniques; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Tumor Cells, Cultured | 2001 |
Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young and aged rats.
Topics: Aging; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Male; Neurons; Nucleus Accumbens; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors | 2001 |
Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology.
Topics: Amino Acid Substitution; Animals; Biological Transport; Chlorocebus aethiops; Cocaine; Codon; COS Cells; Desipramine; Dopamine; Fluoxetine; Humans; Kinetics; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Structure-Activity Relationship; Symporters; Transfection; Tyrosine | 2001 |
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.
Topics: Animals; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Frontal Lobe; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Symporters; Synaptosomes | 2002 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Female; Fenfluramine; Fetus; Fluoxetine; Methiothepin; Neostriatum; Nucleus Accumbens; p-Chloroamphetamine; Potassium; Pregnancy; Prenatal Exposure Delayed Effects; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents | 2002 |
Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter.
Topics: Adrenergic Uptake Inhibitors; Amino Acid Substitution; Animals; Binding Sites; Cocaine; COS Cells; Desipramine; Dopamine Uptake Inhibitors; Fluoxetine; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Isoforms; Symporters; Transfection | 2002 |
Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts.
Topics: Animals; Antidepressive Agents; Binding Sites; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Membrane Potentials; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Symporters; Trophoblasts | 2002 |
Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cocaine; Desipramine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electric Stimulation; Electrochemistry; Extracellular Space; Fluoxetine; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Reinforcement, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Symporters | 2002 |
Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Cell Line; Cocaine; Conserved Sequence; COS Cells; Desipramine; Dopamine Agents; Female; Fluoxetine; Gene Expression; Glutamic Acid; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ovary; Sequence Homology, Amino Acid; Sodium; Structure-Activity Relationship; Symporters; Transfection | 2002 |
Adolescent cocaine exposure and offensive aggression: involvement of serotonin neural signaling and innervation in male Syrian hamsters.
Topics: Aggression; Animals; Cocaine; Cricetinae; Fluoxetine; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Mesocricetus; Nerve Fibers; Neurons, Afferent; Selective Serotonin Reuptake Inhibitors; Serotonin; Signal Transduction | 2002 |
A cocaine insensitive chimeric insect serotonin transporter reveals domains critical for cocaine interaction.
Topics: Amino Acid Sequence; Animals; Biological Transport; Carrier Proteins; Cell Line; Chlorides; Chlorocebus aethiops; Cloning, Molecular; Cocaine; Drug Resistance; Fluoxetine; Humans; Hydrophobic and Hydrophilic Interactions; Insect Proteins; Manduca; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Selective Serotonin Reuptake Inhibitors; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Sodium; Species Specificity; Structure-Activity Relationship | 2002 |
Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.
Topics: Animals; Carrier Proteins; Cocaine; Conditioning, Psychological; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Gene Deletion; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neuropeptides; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Symporters; Vesicular Biogenic Amine Transport Proteins | 2002 |
The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Binding Sites; Cell Line; Cocaine; Conserved Sequence; Desipramine; Enzyme Inhibitors; Fluoxetine; Glycine; Humans; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Sequence Alignment; Symporters; Vasoconstrictor Agents | 2002 |
Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats.
Topics: Acetylcholine; Animals; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Long-Evans; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Visual Cortex | 2002 |
Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey.
Topics: Animals; Autoradiography; Cocaine; Deoxyglucose; Fluoxetine; Macaca mulatta; Male; Norepinephrine Plasma Membrane Transport Proteins; Self Administration; Septal Nuclei; Symporters; Time Factors; Up-Regulation | 2003 |
Effects of fluoxetine and d-fenfluramine on cocaine-seeking behavior in rats.
Topics: Animals; Behavior, Addictive; Cocaine; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Rats; Rats, Sprague-Dawley; Reaction Time | 2003 |
Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Fluvoxamine; Injections, Intraperitoneal; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2003 |
Actions of amphetamine derivatives and cathinone at the noradrenaline transporter.
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic Uptake Inhibitors; Alkaloids; Amphetamines; Animals; Cerebral Cortex; Cocaine; Competitive Bidding; Fluoxetine; In Vitro Techniques; Male; Myocardium; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Wistar; Symporters | 2003 |
Regulating the conducting states of a mammalian serotonin transporter.
Topics: Animals; Antigens, Surface; Binding Sites; Botulinum Toxins, Type A; Carrier Proteins; Cells, Cultured; Choline; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Electric Conductivity; Embryo, Mammalian; Embryo, Nonmammalian; Fluoxetine; Humans; Immunoblotting; Isotope Labeling; Kidney; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Microinjections; Molecular Biology; Munc18 Proteins; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurons; Oocytes; Patch-Clamp Techniques; Peptide Fragments; Proteins; Radiopharmaceuticals; Rats; Recombinant Fusion Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Sodium; Syntaxin 1; Thalamus; Time Factors; Tritium; Vesicular Transport Proteins; Xenopus laevis | 2003 |
Role of serotonin in cocaine effects in mice with reduced dopamine transporter function.
Topics: Animals; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nucleus Accumbens; Reinforcement, Psychology; Serotonin; Serotonin Plasma Membrane Transport Proteins; Ventral Tegmental Area | 2004 |
Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Citalopram; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Sertraline; Tissue Distribution | 2004 |
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain.
Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression Regulation; Male; p-Chloroamphetamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Time; Up-Regulation | 2004 |
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzazepines; Brain; Caffeine; Central Nervous System Stimulants; Cocaine; Desipramine; Dopamine Antagonists; Dronabinol; Enzyme Activation; Fluoxetine; Immunohistochemistry; Male; Mice; Mitogen-Activated Protein Kinases; Morphine; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Scopolamine; Selective Serotonin Reuptake Inhibitors | 2004 |
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
Topics: Animals; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extracellular Space; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Nucleus Accumbens; Piperazines; Prefrontal Cortex; Putamen; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereotaxic Techniques | 2004 |
Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex.
Topics: Animals; Biological Transport; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Synaptosomes; Time Factors; Tritium | 2004 |
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.
Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Northern; Central Nervous System; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors | 2004 |
Differential regulation of cocaine-induced locomotor activity in inbred long-sleep and short-sleep mice by dopamine and serotonin systems.
Topics: Animals; Cocaine; Dopamine Antagonists; Fluoxetine; Male; Mice; Mice, Inbred Strains; Motor Activity; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Sleep; Species Specificity | 2004 |
A fatal overdose of cocaine associated with coingestion of marijuana, buprenorphine, and fluoxetine. Body fluid and tissue distribution of cocaine and its metabolites determined by hydrophilic interaction chromatography-mass spectrometry(HILIC-MS).
Topics: Analgesics, Opioid; Biotransformation; Buprenorphine; Cannabinoids; Chromatography, Liquid; Cocaine; Drug Overdose; Fatal Outcome; Fluoxetine; Hair; HIV Seropositivity; Humans; Indicators and Reagents; Male; Marijuana Smoking; Middle Aged; Opioid-Related Disorders; Reference Standards; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Solvents; Spectrometry, Mass, Electrospray Ionization; Substance-Related Disorders | 2004 |
Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens.
Topics: Animals; Biological Assay; Cocaine; Desipramine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Extracellular Fluid; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Organ Culture Techniques; Serotonin Plasma Membrane Transport Proteins; Symporters | 2004 |
Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Carbon Isotopes; Cocaine; Deoxyglucose; Dopamine Uptake Inhibitors; Drug Administration Schedule; Fluoxetine; Macaca mulatta; Male; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Self Administration; Tritium | 2005 |
Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers.
Topics: Antibodies; Antibody Specificity; Binding Sites; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Fluoxetine; Humans; Immunoblotting; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Symporters; Up-Regulation | 2005 |
Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity.
Topics: Binding Sites; Binding, Competitive; Brain Chemistry; Buffers; Cell Line; Cell Membrane; Cocaine; Dopamine Uptake Inhibitors; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Radioligand Assay; Reproducibility of Results; Symporters; Temperature | 2005 |
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Mapping; Clonidine; Cocaine; Cognition Disorders; Discrimination Learning; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluoxetine; Macaca mulatta; Male; Membrane Proteins; Memory; Nerve Tissue Proteins; Neuropsychological Tests; Prazosin; Prefrontal Cortex; Radioligand Assay; Receptors, Catecholamine; Statistics as Topic; Tritium | 2005 |
Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum.
Topics: Animals; Antidepressive Agents, Second-Generation; Arylalkylamine N-Acetyltransferase; Behavior, Addictive; Brain; CLOCK Proteins; Cocaine; Corpus Striatum; Depression; Dopamine Uptake Inhibitors; Fluoxetine; Gene Expression; Hippocampus; Mice; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Trans-Activators | 2005 |
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Benzazepines; Cocaine; Desipramine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Neurotransmitter Uptake Inhibitors; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrodotoxin | 2005 |
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.
Topics: Amines; Benztropine; Binding Sites; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Muscarinic Antagonists; Parasympatholytics; Pirenzepine | 2005 |
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
Topics: Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blotting, Western; Cadmium; Cell Line; Cell Membrane; Citalopram; Clomipramine; Cocaine; Cysteine; Dopamine Uptake Inhibitors; Fluoxetine; HeLa Cells; Humans; Immunoprecipitation; Isoleucine; Kinetics; LLC-PK1 Cells; Mazindol; Methionine; Mice; Models, Chemical; Molecular Sequence Data; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Nomifensine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Radiopharmaceuticals; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Species Specificity; Stereoisomerism; Substrate Specificity; Tyrosine | 2006 |
Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.
Topics: Acoustic Stimulation; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Inhibition, Psychological; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Reaction Time; Reflex, Startle; Selective Serotonin Reuptake Inhibitors | 2006 |
Clock genes: influencing and being influenced by psychoactive drugs.
Topics: Animals; Antidepressive Agents, Second-Generation; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Central Nervous System; Circadian Rhythm; CLOCK Proteins; Cocaine; Dopamine Uptake Inhibitors; Fluoxetine; Gene Expression Regulation; Humans; Mice; Mice, Knockout; Psychotropic Drugs; Receptor, Melatonin, MT1; Signal Transduction; Trans-Activators; Transcription Factors | 2006 |
Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Brain; Brain Chemistry; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Female; Fluoxetine; Inhibition, Psychological; Iron; Iron Deficiencies; Linear Models; Liver; Male; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex, Acoustic; Reflex, Startle; Sex Factors | 2006 |
Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cocaine; DNA-Binding Proteins; Epigenesis, Genetic; Fluoxetine; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Methyl-CpG-Binding Protein 2; Rats; Rats, Wistar; RNA, Messenger; Serotonin | 2006 |
Severe stuttering and motor tics responsive to cocaine.
Topics: Adult; Cocaine; Dopamine Agonists; Fluoxetine; Humans; Levodopa; Male; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Stuttering; Tics | 2007 |
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS.
Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin | 2007 |
Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys.
Topics: Animals; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Female; Fluoxetine; Macaca mulatta; Male; Selective Serotonin Reuptake Inhibitors; Self Administration; Tropanes | 2007 |
Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Antidepressive Agents; Chlorocebus aethiops; Cocaine; COS Cells; Cysteine; Fluoxetine; Humans; Molecular Sequence Data; Mutation; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Structure, Tertiary; Radioligand Assay | 2007 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Male; Methylphenidate; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2007 |
Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Addictive; Behavior, Animal; Clonidine; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Interactions; Extinction, Psychological; Fluoxetine; Flupenthixol; Grooming; Hydrocortisone; Injections, Intravenous; Norepinephrine; Piperazines; Prazosin; Propranolol; Receptors, Adrenergic, alpha-2; Saimiri; Saliva; Self Administration; Thiophenes | 2007 |
Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.
Topics: Binding Sites; Binding, Competitive; Blotting, Western; Cells, Cultured; Cocaine; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay | 2007 |
Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Chemistry; Clonidine; Cocaine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluoxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sex Characteristics; Tetrahydronaphthalenes | 2007 |
Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin.
Topics: Animals; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Female; Fluoxetine; Male; Mice; Mice, Knockout; Mice, Transgenic; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission | 2007 |
Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.
Topics: Aniline Compounds; Animals; Autoradiography; Binding, Competitive; Carboxylesterase; Cocaine; Dopamine Plasma Membrane Transport Proteins; Drug Stability; Fluoxetine; Kinetics; Male; Norepinephrine Plasma Membrane Transport Proteins; Nortropanes; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Sulfides; Tropanes | 2008 |
Fluoxetine does not alter the ability of dopamine D(1)- and D(2)-like agonists to substitute for cocaine in squirrel monkeys.
Topics: Animals; Cocaine; Dopamine Agonists; Fluoxetine; Receptors, Dopamine D1; Receptors, Dopamine D2; Saimiri | 2009 |
Reduced sensitivity to the locomotor-stimulant effects of cocaine is associated with increased sensitivity to its discriminative stimulus properties.
Topics: Amphetamines; Animals; Cocaine; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Combinations; Fluoxetine; Generalization, Stimulus; Motor Activity; Rats; Rats, Long-Evans; Reinforcement Schedule; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists | 2009 |
In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Estradiol; Fluoxetine; Gonadal Hormones; Male; Norepinephrine Plasma Membrane Transport Proteins; Orchiectomy; Protein Binding; Rats; Rats, Sprague-Dawley; Testosterone Propionate; Time Factors; Tritium | 2009 |
Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Male; Mice; Norepinephrine; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin; Taste | 2009 |
Quantitative evaluation of serotonin release and clearance in Drosophila.
Topics: Animals; Animals, Genetically Modified; Channelrhodopsins; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drosophila; Electrochemistry; Extracellular Fluid; Fluoxetine; Ganglia, Invertebrate; Microelectrodes; Nervous System; Neurons; Photic Stimulation; Photochemistry; Selective Serotonin Reuptake Inhibitors; Serotonin | 2009 |
Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Chlorides; Cocaine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fluoxetine; Ibogaine; Imipramine; Models, Chemical; Mutation; Protein Conformation; Protein Stability; Rats; RNA-Binding Proteins | 2009 |
Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry.
Topics: Animals; Animals, Genetically Modified; Central Nervous System; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drosophila melanogaster; Fluoxetine; Hydrazines; Microelectrodes; Reserpine | 2009 |
N-methyl amine-substituted fluoxetine derivatives: new dopamine transporter inhibitors.
Topics: Antidepressive Agents, Second-Generation; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electrophysiology; Ethanolamines; Fluoxetine; Humans; Imidazoles; Phenyl Ethers; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2009 |
Characterization of 5-HT transporter and receptor system in HeLaS3 cells by [(3)H]8-OH-DPAT and other serotonergic ligands.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Binding, Competitive; Biogenic Amines; Cocaine; Fluoxetine; HeLa Cells; Humans; Kinetics; Ligands; Paroxetine; Radioligand Assay; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Vesicular Biogenic Amine Transport Proteins | 2011 |
A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid.
Topics: Analysis of Variance; Animals; Appetitive Behavior; Baclofen; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Consummatory Behavior; Dopamine Antagonists; Dose-Response Relationship, Drug; Fluoxetine; GABA-B Receptor Agonists; Haloperidol; Infusions, Intravenous; Male; Models, Theoretical; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors; Self Administration; Time Factors | 2011 |
Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.
Topics: Amphetamine; Benztropine; Binding Sites; Biotinylation; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Fluoxetine; HEK293 Cells; Humans; Immunoblotting; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Pharmacokinetics; Protein Conformation | 2011 |
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride | 2010 |
Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.
Topics: Binding, Competitive; Cocaine; Fluoxetine; HEK293 Cells; Humans; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Radiopharmaceuticals; Tritium | 2012 |
Early intervention with psychostimulants or antidepressants to increase methyl-CpG-binding protein 2 (MeCP2) expressions: a potential therapy for Rett syndrome.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cocaine; Early Medical Intervention; Female; Fluoxetine; Gene Expression Regulation; Humans; Methyl-CpG-Binding Protein 2; Models, Biological; Rett Syndrome; X Chromosome Inactivation | 2012 |
Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Fenfluramine; Fluoxetine; Functional Neuroimaging; Macaca mulatta; Male; Microdialysis; Positron-Emission Tomography; Prolactin; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2012 |
Selective serotonin re-uptake inhibitors potentiate gene blunting induced by repeated methylphenidate treatment: Zif268 versus Homer1a.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Combinations; Drug Synergism; Early Growth Response Protein 1; Fluoxetine; Homer Scaffolding Proteins; Male; Methylphenidate; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2014 |
In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17.
Topics: Cocaine; Computer Simulation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Fluoxetine; Imipramine; Molecular Docking Simulation; Molecular Dynamics Simulation; Organic Chemicals; Polymorphism, Genetic; Protein Conformation; Quinidine; Regression Analysis; Stereoisomerism; Thioridazine | 2014 |
Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Behavior, Animal; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Exploratory Behavior; Fluoxetine; Flupenthixol; Idazoxan; Male; Motor Activity; Piperazines; Play and Playthings; Propylamines; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Social Behavior | 2014 |
Dissociations between interval timing and intertemporal choice following administration of fluoxetine, cocaine, or methamphetamine.
Topics: Animals; Behavior, Animal; Choice Behavior; Cocaine; Dopamine Uptake Inhibitors; Fluoxetine; Impulsive Behavior; Learning; Methamphetamine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Time Perception | 2014 |
Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice.
Topics: Animals; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Fluoxetine; Gene Expression; Male; MAP Kinase Signaling System; Methylphenidate; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Psychotropic Drugs; RNA, Messenger; Second Messenger Systems; Space Perception; Time Factors; Ventral Tegmental Area | 2014 |
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity.
Topics: Animals; Antidepressive Agents; Citalopram; Cocaine; Depression; Disease Models, Animal; Female; Fluoxetine; Male; Medicine, Chinese Traditional; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Rats; Rats, Sprague-Dawley; Saponins; Swimming; Tritium | 2014 |
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors.
Topics: Aminopyridines; Animals; Cocaine; Cocaine-Related Disorders; Cues; Drug-Seeking Behavior; Ethylamines; Fluoxetine; Indoles; Saimiri; Self Administration; Serotonin 5-HT2 Receptor Agonists | 2015 |
Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Autoradiography; Brain; Cocaine; Cocaine-Related Disorders; Fluoxetine; Idazoxan; Macaca mulatta; Male; Neural Pathways; Norepinephrine Plasma Membrane Transport Proteins; Receptors, Adrenergic, alpha-2; Reinforcement Schedule; Self Administration | 2016 |
Fluoxetine exposure during adolescence increases preference for cocaine in adulthood.
Topics: Age Factors; Animals; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Food Preferences; Male; Mice, Inbred C57BL; Reward; Selective Serotonin Reuptake Inhibitors; Time Factors | 2015 |
Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats.
Topics: Acoustic Stimulation; Amphetamine; Analgesics; Animals; Antidepressive Agents; Association Learning; Central Nervous System Stimulants; Cocaine; Conditioning, Classical; Decision Making; Depressive Disorder, Major; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluoxetine; Ketamine; Male; Models, Biological; Phencyclidine; Rats; Reaction Time; Time Factors | 2017 |
Serotonin transporter inhibition and 5-HT
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Locomotion; Methylphenidate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Neostriatum; Receptor, Serotonin, 5-HT2C; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2019 |