Compounds > cocaine

cocaine and enkephalin, ala(2)-mephe(4)-gly(5)-

cocaine has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.14)18.7374
1990's14 (50.00)18.2507
2000's12 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Horne-King, J; Kreek, MJ; Unterwald, EM1
Billings, B; Candido, J; Duttaroy, A; Lutfy, K; Sierra, V; Yoburn, BC; Zito, SW1
Marshall, KC; Williams, JT1
DuMars, LA; Kalivas, PW; Rodger, LD1
Kreek, MJ; Rubenfeld, JM; Unterwald, EM1
Ho, A; Kreek, MJ; Maisonneuve, IM1
Kameyama, T; Mizutani, M; Ukai, M1
Cote, TE; Cox, BM; Izenwasser, S; Kreek, MJ; Unterwald, EM1
Kameyama, T; Mori, E; Ukai, M1
Cox, BM; Heller, B; Izenwasser, S1
Kishimoto, Y; Maeda, J; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M1
Azaryan, AV; Clock, BJ; Cox, BM; Rosenberger, JG1
DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE1
Adamson, KL; Chow, BL; Coen, KM; Corrigall, WA2
Duffy, P; Kalivas, PW; Mackler, SA1
Goodman, CB; London, ED; Pilotte, NS; Sharpe, LG; Shippenberg, TS1
Bian, D; Cannon, DG; Kim, SA; Martin, TJ; Porreca, F; Sizemore, GM; Smith, JE1
Adamson, L; Coen, KM; Corrigall, WA; Zhang, J1
Niculescu, M; Schroeder, JA; Unterwald, EM1
Georgieva, J; Kitchen, I; Rosin, A1
Izenwasser, S; Platt, DM; Rowlett, JK; Spealman, RD1
Childers, SR; Davies, HM; Gregg, TC; O'Connor, KA1
Bailey, A; Gianotti, R; Ho, A; Kreek, MJ1
Bhat, R; Chari, G; Rao, R1
Deniau, JM; Ezan, P; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S1
Self, DW; Simmons, D1
Soderman, AR; Unterwald, EM1

Other Studies

28 other study(ies) available for cocaine and enkephalin, ala(2)-mephe(4)-gly(5)-

ArticleYear
Chronic cocaine alters brain mu opioid receptors.
    Brain research, 1992, Jul-03, Volume: 584, Issue:1-2

    Topics: Animals; Autoradiography; Brain; Brain Chemistry; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Rats; Receptors, Opioid; Receptors, Opioid, mu; Up-Regulation

1992
Potentiation of opioid analgesia by cocaine: the role of spinal and supraspinal receptors.
    Life sciences, 1992, Volume: 50, Issue:8

    Topics: Analgesics, Opioid; Animals; Brain; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Receptors, Opioid; Spinal Cord

1992
Membrane properties and adrenergic responses in locus coeruleus neurons of young rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:11

    Topics: Adrenergic alpha-Agonists; Animals; Cocaine; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Norepinephrine; Phenylephrine; Prazosin; Rats

1987
Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region.
    Behavioural brain research, 1988, Volume: 27, Issue:1

    Topics: Animals; Brain; Cocaine; Dopamine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Motor Activity; Movement; Neurons; Rats; Rats, Inbred Strains; Stereotyped Behavior

1988
Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors.
    Neuroreport, 1994, Aug-15, Volume: 5, Issue:13

    Topics: Analgesics; Animals; Autoradiography; Brain; Brain Chemistry; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Up-Regulation

1994
Chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: an in vivo microdialysis study.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2

    Topics: Analysis of Variance; Animals; Cocaine; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microdialysis; Rats; Rats, Inbred F344

1995
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1994, Volume: 14, Issue:3

    Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides

1994
Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity.
    Synapse (New York, N.Y.), 1993, Volume: 15, Issue:1

    Topics: Adenylyl Cyclases; Analgesics; Animals; Caudate Nucleus; Cocaine; Cyclic AMP; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Nucleus Accumbens; Putamen; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values

1993
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
    European journal of pharmacology, 1993, Jan-26, Volume: 231, Issue:1

    Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu

1993
Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens.
    European journal of pharmacology, 1996, Feb-15, Volume: 297, Issue:1-2

    Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Membranes; Narcotics; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1996
Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats.
    European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Narcotics; Pyrrolidines; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders

1997
Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration.
    Canadian journal of physiology and pharmacology, 1998, Volume: 76, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics, Opioid; Animals; Benzopyrans; Bromocriptine; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation; Male; Nucleus Accumbens; Oxazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Time Factors; Up-Regulation

1998
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections.
    Drug and alcohol dependence, 1998, Oct-01, Volume: 52, Issue:2

    Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration

1998
The mu opioid agonist DAMGO alters the intravenous self-administration of cocaine in rats: mechanisms in the ventral tegmental area.
    Psychopharmacology, 1999, Volume: 141, Issue:4

    Topics: Analgesics, Opioid; Animals; Cocaine; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intravenous; Male; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Administration; Ventral Tegmental Area

1999
Interrupted expression of NAC-1 augments the behavioral responses to cocaine.
    Synapse (New York, N.Y.), 1999, Volume: 33, Issue:2

    Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microdialysis; Microinjections; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Repressor Proteins; RNA, Messenger

1999
Manipulations of mu-opioid and nicotinic cholinergic receptors in the pontine tegmental region alter cocaine self-administration in rats.
    Psychopharmacology, 1999, Volume: 145, Issue:4

    Topics: Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Microinjections; Pons; Rats; Rats, Long-Evans; Receptors, Nicotinic; Receptors, Opioid, mu; Self Administration; Somatostatin; Ventral Tegmental Area

1999
Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain.
    Synapse (New York, N.Y.), 2000, Sep-15, Volume: 37, Issue:4

    Topics: Analgesics, Opioid; Animals; Autoradiography; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Iodine Radioisotopes; Limbic System; Male; Nucleus Accumbens; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Septal Nuclei; Substance Withdrawal Syndrome

2000
Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Analgesics, Opioid; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Heroin; Injections, Intraventricular; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Reinforcement, Psychology; Self Administration

2000
Pharmacological manipulations of the pedunculopontine tegmental nucleus in the rat reduce self-administration of both nicotine and cocaine.
    Psychopharmacology, 2002, Volume: 160, Issue:2

    Topics: Animals; Behavior, Animal; Carbachol; Central Nervous System Agents; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Nicotine; Rats; Rats, Long-Evans; Scopolamine; Self Administration; Substance-Related Disorders; Tegmentum Mesencephali

2002
Cocaine alters mu but not delta or kappa opioid receptor-stimulated in situ [35S]GTPgammaS binding in rat brain.
    Synapse (New York, N.Y.), 2003, Volume: 47, Issue:1

    Topics: Analgesics, Opioid; Animals; Autoradiography; Brain; Caudate Nucleus; Cocaine; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gyrus Cinguli; Heterotrimeric GTP-Binding Proteins; Male; Nucleus Accumbens; Putamen; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors

2003
Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study.
    Brain research, 2003, Jul-18, Volume: 978, Issue:1-2

    Topics: Anesthetics, Local; Animals; Autoradiography; Binding Sites; Brain Mapping; Central Nervous System; Central Nervous System Depressants; Cocaine; Dihydropyridines; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Oximes; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Tritium

2003
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration

2004
Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain.
    Neuropharmacology, 2005, Volume: 48, Issue:1

    Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Cocaine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Isotopes; Male; Membrane Transport Modulators; Membrane Transport Proteins; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Spiperone; Time

2005
Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats.
    Synapse (New York, N.Y.), 2005, Sep-01, Volume: 57, Issue:3

    Topics: Adenosine; Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Cocaine; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Tritium; Up-Regulation; Xanthines

2005
Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development.
    Life sciences, 2006, Feb-23, Volume: 78, Issue:13

    Topics: Aging; Animals; Brain; Cocaine; Dopamine Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sulpiride

2006
Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum.
    The European journal of neuroscience, 2007, Volume: 25, Issue:5

    Topics: Acetylcholine; Animals; Behavior, Animal; Brain Injuries; Circadian Rhythm; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; Functional Laterality; Male; Models, Neurological; N-Methylaspartate; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium

2007
Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:8

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; beta-Endorphin; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Recurrence; Reward; Self Administration; Substance Withdrawal Syndrome

2009
Cocaine-induced mu opioid receptor occupancy within the striatum is mediated by dopamine D2 receptors.
    Brain research, 2009, Nov-03, Volume: 1296

    Topics: Animals; Autoradiography; Brain; Cocaine; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Nucleus Accumbens; Opioid Peptides; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, mu; Time Factors; Tritium

2009