cocaine has been researched along with clozapine in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (12.96) | 18.7374 |
| 1990's | 8 (14.81) | 18.2507 |
| 2000's | 21 (38.89) | 29.6817 |
| 2010's | 16 (29.63) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Sen, S; Sinha, N | 1 |
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Keserü, GM | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Ellinwood, EH; Kilbey, MM | 1 |
| Fitch, T; Loh, EA; Roberts, DC; Vickers, G | 1 |
| Bergman, J; Spealman, RD | 1 |
| Dougan, DF; Duffield, P; Wade, DN | 1 |
| Arbilla, S; Baud, P; Langer, SZ | 1 |
| Gross, G; Schümann, HJ | 1 |
| Roberts, DC; Vickers, G | 1 |
| Gibb, JW; Gygi, SP; Hanson, GR | 1 |
| Opler, LA; Yovell, Y | 1 |
| Kosten, TA; Nestler, EJ | 1 |
| Piercey, MF; Vanover, KE; Woolverton, WL | 1 |
| Hameedi, FA; Kosten, TR; Navui, SA; Sernyak, MJ | 1 |
| Bunzow, JR; Chester, JA; Dziewczapolski, G; Falzone, TL; Fang, Y; Gershanik, O; Grandy, DK; Larson, JL; Low, MJ; McDougall, JA; Phillips, TJ; Pugsley, TA; Rubinstein, M; Saez, C; Zhang, G | 1 |
| Dadmarz, M; Ufer, M; Vogel, WH | 1 |
| Audinot, V; Brocco, M; Dekeyne, A; Despaux, N; Maiofiss, L; Millan, MJ; Newman-Tancredi, A; Peglion, JL; Queriaux, S; Rivet, JM | 1 |
| Farren, CK; Hameedi, FA; Jatlow, P; Kosten, TR; Rosen, MA; Woods, S | 1 |
| Gessa, GL; Marchese, G; Pani, L; Ruiu, S; Saba, PL | 1 |
| Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Xiong, X | 1 |
| Cho, H; Cho, YS; Choi, KI; Jeong, D; Jung, JY; Jung, SH; Kim, GD; Koh, HY; Kong, JY; Lee, S; Pae, AN; Park, WK; Yun, CW | 1 |
| Broderick, PA; Hope, O; Okonji, C; Rahni, DN; Zhou, Y | 1 |
| Banerjee, SP; Gashi, E; Lidsky, TI; Wang, HY; Yablonsky-Alter, E | 1 |
| Caine, SB; Fink-Jensen, A; Thomsen, M; Wess, J; Woldbye, DP; Wörtwein, G | 1 |
| Bateup, HS; Gong, S; Greengard, P; Heintz, N; Kuroiwa, M; Nishi, A; Svenningsson, P | 1 |
| Cui, FJ; Hwang, JY; Kang, UG; Park, HJ | 1 |
| Figueredo, VM | 1 |
| Calakos, N; Caron, MG; Daigle, TL; Farrell, MS; Guettier, JM; Huang, XP; Hufeisen, SJ; Lee, HM; Moy, SS; Nonneman, RJ; Pei, Y; Roth, BL; Sciaky, N; Simmons, A; Urban, DJ; Wan, Y; Wess, J; Yadav, PN | 1 |
| Adrover, MF; Alvarez, VA; Bock, R; Christensen, CH; Dobi, A; Gremel, CM; Kaplan, AR; Kramer, PF; Markey, E; Shin, JH | 1 |
| Boger, HA; Haydon, PG; Kalivas, PW; Li, H; Scofield, MD; Smith, RJ | 1 |
| Cox, CD; Gall, CM; Geschwind, DH; Karsten, CA; Lee, D; Peñagarikano, O; Piomelli, D; Wei, D | 1 |
| Hiver, A; Lüscher, C; Pascoli, V; Terrier, J | 1 |
| Aston-Jones, G; McGlinchey, EM | 1 |
| Knackstedt, LA; Padovan-Hernandez, Y | 1 |
| Deyama, S; Domoto, M; Hinoi, E; Kaneda, K; Kaneko, S; Nagayasu, K; Nishitani, N; Sasase, H; Wada, S; Yanagida, J; Zhang, T | 1 |
| Barry, SM; Giannotti, G; McGinty, JF; Peters, J; Siemsen, BM | 1 |
| Berry, AJ | 1 |
| Chen, X; Huang, B; Liu, X; Liu, Z; Ma, C; Ma, L; Su, X; Tian, Z; Yan, E; Zhou, Y; Zhu, H | 1 |
| Batra, A; Brodnik, ZD; España, RA; Kortagere, S; Lewandowski, SI; Mahler, SV; Mortensen, OV; Ruiz, CM; Xu, W | 1 |
| Bardo, MT; Beckmann, JS; Grinevich, V; Hammerslag, LR; Humburg, BA; Malone, SG; Saatman, KE | 1 |
1 review(s) available for cocaine and clozapine
| Article | Year |
|---|---|
Chemical cardiomyopathies: the negative effects of medications and nonprescribed drugs on the heart.
Topics: Amphetamine; Anabolic Agents; Anthracyclines; Antineoplastic Agents; Cardiomyopathies; Chloroquine; Clozapine; Cocaine; Doxorubicin; Ephedra; Ethanol; Heart; Humans; Methylphenidate; Nonprescription Drugs; Prescription Drugs; Testosterone | 2011 |
1 trial(s) available for cocaine and clozapine
| Article | Year |
|---|---|
Significant interaction between clozapine and cocaine in cocaine addicts.
Topics: Adult; Arousal; Clozapine; Cocaine; Cocaine-Related Disorders; Comorbidity; Dose-Response Relationship, Drug; Drug Interactions; Euphoria; Humans; Male; Risk Factors; Schizophrenia; Syncope | 2000 |
52 other study(ies) available for cocaine and clozapine
| Article | Year |
|---|---|
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Discriminative stimulus properties of psychomotor stimulants in the cat.
Topics: Animals; Cats; Central Nervous System Stimulants; Clozapine; Cocaine; Dextroamphetamine; Discrimination, Psychological; Feeding Behavior; Female; Male; Morphine; Reinforcement Schedule | 1979 |
Clozapine increases breaking points on a progressive-ratio schedule reinforced by intravenous cocaine.
Topics: Animals; Clozapine; Cocaine; Conditioning, Operant; Dopamine; Injections, Intravenous; Male; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Serotonin | 1992 |
Some behavioral effects of histamine H1 antagonists in squirrel monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpheniramine; Cimetidine; Clozapine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diphenhydramine; Electroshock; Feeding Behavior; Histamine H1 Antagonists; Male; Promethazine; Saimiri; Self Administration; Tripelennamine | 1986 |
Modulation of dopamine receptors in the Tapes clam by dextroamphetamine and phenylethanolamine.
Topics: Adenosine Monophosphate; Amantadine; Animals; Benztropine; Bivalvia; Chlorphenamidine; Clozapine; Cocaine; Dextroamphetamine; Dopamine; Ethanolamines; Heart Rate; Myocardial Contraction; Receptors, Dopamine; Serotonin; Tetrahydronaphthalenes | 1987 |
Inhibition of the electrically evoked release of [3H]acetylcholine in rat striatal slices: an experimental model for drugs that enhance dopaminergic neurotransmission.
Topics: Acetylcholine; Amphetamine; Animals; Chlorpromazine; Clozapine; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Haloperidol; Male; Nomifensine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride; Synaptic Transmission | 1985 |
Enhancement of noradrenaline release from rat cerebral cortex by neuroleptic drugs.
Topics: Amitriptyline; Animals; Antipsychotic Agents; Cerebral Cortex; Clozapine; Cocaine; In Vitro Techniques; Male; Norepinephrine; Promazine; Rats; Stimulation, Chemical | 1980 |
Atypical neuroleptics increase self-administration of cocaine: an evaluation of a behavioural screen for antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Clozapine; Cocaine; Drug Evaluation, Preclinical; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Self Administration | 1984 |
Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Cocaine; Corpus Striatum; Dopamine; Dopamine D2 Receptor Antagonists; Extrapyramidal Tracts; Globus Pallidus; Hallucinogens; Haloperidol; Limbic System; Male; Methamphetamine; Neurotensin; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1994 |
Clozapine reverses cocaine craving in a treatment-resistant mentally ill chemical abuser: a case report and a hypothesis.
Topics: Adult; Clozapine; Cocaine; Comorbidity; Diagnosis, Dual (Psychiatry); Drug Therapy, Combination; Fluphenazine; Humans; Lithium; Male; Psychotic Disorders; Substance-Related Disorders; Treatment Outcome | 1994 |
Clozapine attenuates cocaine conditioned place preference.
Topics: Analysis of Variance; Animals; Clozapine; Cocaine; Conditioning, Classical; Male; Rats; Rats, Sprague-Dawley; Spatial Behavior | 1994 |
Evaluation of the reinforcing and discriminative stimulus effects of cocaine in combination with (+)-AJ76 or clozapine.
Topics: Animals; Clozapine; Cocaine; Discrimination Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Reinforcement, Psychology; Tetrahydronaphthalenes | 1993 |
Near syncope associated with concomitant clozapine and cocaine use.
Topics: Administration, Intranasal; Adult; Blood Pressure; Clozapine; Cocaine; Drug Interactions; Heart Rate; Humans; Male; Schizophrenia; Substance-Related Disorders; Syncope | 1996 |
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Depressants; Clozapine; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Ethanol; Genotype; Humans; Levodopa; Locomotion; Maternal Behavior; Methamphetamine; Mice; Mice, Knockout; Molecular Sequence Data; Motor Activity; Mutagenesis, Site-Directed; Narcotics; Nucleus Accumbens; Receptors, Dopamine D2; Receptors, Dopamine D4; Sensitivity and Specificity; Substantia Nigra; Transcription, Genetic | 1997 |
Voluntary consumption of amphetamine, cocaine, ethanol and morphine by rats as influenced by a preceding period of forced drug intake and clozapine.
Topics: Administration, Oral; Amphetamine; Animals; Central Nervous System Depressants; Clozapine; Cocaine; Dopamine Agents; Ethanol; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders | 1999 |
S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multipara
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Aggression; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Imidazoles; Isoxazoles; Male; Mice; Pain Measurement; Protein Binding; Rats; Rats, Wistar; Receptors, Histamine; Receptors, Muscarinic | 2000 |
The 5-HT2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex.
Topics: Animals; Clozapine; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Frontal Lobe; Haloperidol; Ketanserin; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Risperidone; Ritanserin; Serotonin Antagonists; Synaptosomes; Tritium | 2000 |
5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization.
Topics: Animals; Behavior, Animal; Clozapine; Cocaine; Injections; Ketanserin; Male; Mianserin; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Substance Withdrawal Syndrome | 2002 |
Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110.
Topics: Animals; Antipsychotic Agents; Benzamides; Binding, Competitive; Body Temperature; Catalepsy; Cell Line; Clozapine; Cocaine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Humans; Hypothermia; Isoxazoles; Male; Mice; Motor Activity; Prolactin; Psychomotor Performance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiophenes; Tritium | 2003 |
Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Clozapine; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electrophysiology; Male; Microelectrodes; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome | 2004 |
Clozapine protection against gestational cocaine-induced neurochemical abnormalities.
Topics: Animals; Brain; Clozapine; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Female; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Uterus | 2005 |
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cocaine; Dextroamphetamine; Dopamine Agonists; Female; Genotype; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Muscarinic Agonists; Receptors, Muscarinic; Reflex; Reflex, Startle; Schizophrenia; Trihexyphenidyl | 2007 |
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Caffeine; Central Nervous System Stimulants; Chromosomes, Artificial, Bacterial; Clozapine; Cocaine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Globus Pallidus; Haloperidol; Mice; Mice, Transgenic; Neurons; Organ Culture Techniques; Phosphorylation; Substantia Nigra | 2008 |
Effects of clozapine on behavioral sensitization induced by cocaine.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cocaine; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred ICR; Motor Activity; Oncogene Protein v-akt; Prefrontal Cortex; Signal Transduction; Substance Withdrawal Syndrome | 2010 |
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Animals, Newborn; Clozapine; Cocaine; Corpus Striatum; Cyclic AMP; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gs; Locomotion; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phosphorylation; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Red Fluorescent Protein | 2013 |
Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bacterial Proteins; Channelrhodopsins; Clozapine; Cocaine; Compulsive Behavior; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Nerve Net; Neural Pathways; Neurons; Nucleus Accumbens; Receptors, Dopamine D2; Reward; Self Administration; Synapses; Time Factors | 2013 |
Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking.
Topics: Animals; Astrocytes; Calcium Channels, N-Type; Central Nervous System Agents; Clozapine; Cocaine; Cocaine-Related Disorders; Cues; Dietary Sucrose; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Genetic Therapy; Glutamic Acid; Male; Mice, Transgenic; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Self Administration; SNARE Proteins | 2015 |
Endocannabinoid signaling mediates oxytocin-driven social reward.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Benzodiazepines; Camphanes; Carbamates; Clozapine; Cocaine; Endocannabinoids; Immunohistochemistry; Infusions, Intraventricular; Lipids; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Oxytocin; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Reward; Signal Transduction; Social Behavior | 2015 |
Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction.
Topics: Animals; Channelrhodopsins; Clozapine; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Food Deprivation; GABA Antagonists; Glutamate Decarboxylase; Limbic System; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Dopamine D1; Self Administration; Sucrose; Synaptic Transmission; Time Factors | 2015 |
Dorsal Hippocampus Drives Context-Induced Cocaine Seeking via Inputs to Lateral Septum.
Topics: Animals; Baclofen; Behavior, Addictive; Clozapine; Cocaine; Cues; Drug-Seeking Behavior; Extinction, Psychological; Hippocampus; Locomotion; Male; Microinjections; Muscimol; Neuroanatomical Tract-Tracing Techniques; Oncogene Proteins v-fos; Rats; Self Administration; Septal Nuclei | 2018 |
Dose-dependent reduction in cocaine-induced locomotion by Clozapine-N-Oxide in rats with a history of cocaine self-administration.
Topics: Animals; Clozapine; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Locomotion; Male; Rats, Sprague-Dawley | 2018 |
Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.
Topics: Animals; Clozapine; Cocaine; Cocaine-Related Disorders; GABAergic Neurons; Humans; Male; Mice; Mice, Transgenic; Nucleus Accumbens; Patch-Clamp Techniques; Reinforcement, Psychology; Reward; Synaptic Potentials | 2018 |
Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking.
Topics: Animals; Brain-Derived Neurotrophic Factor; Clozapine; Cocaine; Drug-Seeking Behavior; Male; Midline Thalamic Nuclei; Neural Pathways; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats, Sprague-Dawley | 2018 |
Acute dyskinesia in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Cocaine-Related Disorders; Crack Cocaine; Dyskinesia, Drug-Induced; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Schizophrenia; Substance Withdrawal Syndrome; Treatment Outcome | 2018 |
A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Clozapine; Cocaine; Conditioning, Psychological; Excitatory Postsynaptic Potentials; Mental Recall; Mice, Transgenic; Neural Pathways; Nucleus Accumbens; Optogenetics; Receptors, Dopamine | 2019 |
Chemogenetic Manipulation of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters.
Topics: Animals; Axons; Clozapine; Cocaine; Cocaine-Related Disorders; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Male; Microinjections; Phosphorylation; Rats; Rats, Long-Evans; Self Administration; Ventral Tegmental Area | 2020 |
Peer-induced cocaine seeking in rats: Comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons.
Topics: Animals; Clozapine; Cocaine; Cocaine-Related Disorders; Cues; Extinction, Psychological; Female; Male; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Rats; Self Administration | 2022 |