cocaine and benzocaine

cocaine has been researched along with benzocaine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19908 (29.63)18.7374
1990's8 (29.63)18.2507
2000's6 (22.22)29.6817
2010's3 (11.11)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Duffy, EM; Jorgensen, WL1
Artursson, P; Bergström, CA; Draheim, R; Holmén, AG; Wassvik, CM1
Batts, TW; Brown, ML; Jones, PJ; Landry, V; Patel, MK; Wang, Y1
Brouillette, WJ; Brown, GB; Zha, C1
Herold, DA; McKinney, CD; Postiglione, KF1
Cattau, EL; Hacker, JF1
Bohn, E; Kunze, H; Vogt, W1
Brown, JK; Chaubal, MG; Malone, MH; Schingler, RH1
Kretzschmar, R; Meyer, HJ; Teschendorf, HJ; Zöllner, B1
Büchi, J; Koller, RJ; Perlia, X1
Belyaev, VI1
Fasanmade, AA1
Andresen, MC; Brodwick, M; Yang, M1
Wang, GK; Wang, SY1
Harkins, JD; Mundy, GD; Rees, WA; Stanley, S; Thompson, KN; Tobin, T; Woods, WE1
Reith, ME; Xu, C1
Wang, GK; Wang, SY; Wright, SN1
Johanson, CE; Schubiner, H; Schuh, KJ1
Marinov, BS; Wang, GK1
ADRIANI, J; ZEPERNICK, R1
Guay, J1
Beaumont, PO; Chakladar, A; Pereskokova, E; Uncles, DR; Willers, JW1
Augusti, R; De Carvalho, TC; Filgueiras, PR; França, HS; Merlo, BB; Ortiz, RS; Rodrigues, RR; Romão, W; Santos, H; Souza, LM; Tosato, F; Vaz, BG1
Aldous, L; Braga, AAC; Gonçalves, LM; Grothe, RA; Lobato, A; Maldaner, AO; Mounssef, B; Paixão, TRLC; Tasić, N1
Dick, JE; Kong, EF; Krushinski, LE; Vannoy, KJ1
Richards, RM; Weir, LF; Xing, JZ1

Reviews

1 review(s) available for cocaine and benzocaine

ArticleYear
Methemoglobinemia related to local anesthetics: a summary of 242 episodes.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Anesthetics, Local; Benzocaine; Child; Child, Preschool; Cocaine; Female; Hemoglobins; Humans; Infant; Lidocaine; Male; Methemoglobinemia; Middle Aged; Pregnancy; Prilocaine; Tetracaine; Young Adult

2009

Trials

2 trial(s) available for cocaine and benzocaine

ArticleYear
Discrimination of intranasal cocaine.
    Behavioural pharmacology, 2000, Volume: 11, Issue:6

    Topics: Administration, Intranasal; Adult; Anesthetics, Local; Benzocaine; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; Male; Perception; Placebos

2000
The effect of formulation on the antimicrobial activity of cetylpyridinium chloride in candy based lozenges.
    Pharmaceutical research, 1996, Volume: 13, Issue:4

    Topics: Administration, Oral; Anesthetics, Local; Anti-Infective Agents, Local; Ascorbic Acid; Benzocaine; Benzyl Alcohol; Benzyl Alcohols; Candida albicans; Candy; Cetylpyridinium; Colony Count, Microbial; Dosage Forms; Eucalyptus; Glucose; Humans; Hydrogen-Ion Concentration; Menthol; Oropharynx; Plants, Medicinal; Saliva; Solubility; Staphylococcus aureus; Streptococcus pyogenes; Sucrose

1996

Other Studies

24 other study(ies) available for cocaine and benzocaine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
Molecular characteristics for solid-state limited solubility.
    Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10

    Topics: Chemical Phenomena; Chemistry, Physical; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Regression Analysis; Solubility

2008
Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Drug Design; Expert Systems; Inhibitory Concentration 50; Lidocaine; Ligands; Models, Molecular; Phenytoin; Sodium Channel Blockers; Structure-Activity Relationship

2009
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
    Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1

    Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels

2014
Benzocaine-adultered street cocaine in association with methemoglobinemia.
    Clinical chemistry, 1992, Volume: 38, Issue:4

    Topics: Adult; Benzocaine; Cocaine; Drug Contamination; Humans; Illicit Drugs; Male; Methemoglobinemia; Substance-Related Disorders

1992
Effects of nasopharyngeal cocaine or pharyngeal benzocaine on esophageal motility.
    The American journal of gastroenterology, 1987, Volume: 82, Issue:2

    Topics: Administration, Intranasal; Adolescent; Adult; Anesthesia, Local; Benzocaine; Cocaine; Esophagogastric Junction; Esophagus; Female; Gastrointestinal Motility; Humans; Male; Nasopharynx

1987
Effects of local anaesthetics on prostaglandin biosynthesis in vitro.
    Biochimica et biophysica acta, 1974, Sep-19, Volume: 360, Issue:3

    Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Animals; Benzocaine; Calcium; Carbon Radioisotopes; Cattle; Chlorpromazine; Chromatography, Thin Layer; Cocaine; Dibucaine; Edetic Acid; Kinetics; Lidocaine; Linoleic Acids; Male; Mepivacaine; Oleic Acids; Phosphatidylethanolamines; Phospholipases; Procaine; Prostaglandins; Seminal Vesicles; Sheep; Snakes; Species Specificity; Tetracaine; Triglycerides

1974
A rapid screening procedure for some "street-drugs" by thin-layer chromatography. II. Cocaine, heroin, local anesthetics and mixtures.
    Journal of chromatography, 1973, Dec-05, Volume: 87, Issue:1

    Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Autoanalysis; Benzocaine; Chromatography, Thin Layer; Cocaine; Drug and Narcotic Control; Ethanol; Evaluation Studies as Topic; Gels; Heroin; Humans; Indicators and Reagents; Methods; Procaine; Silicon Dioxide

1973
[Spasmolytic effect of aryl-substituted alpha-pyrones and aqueous extracts of Piper methysticum Forst].
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 180, Issue:2

    Topics: Animals; Anticonvulsants; Benzocaine; Chromatography, Thin Layer; Cocaine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Muscle Contraction; Muscle, Smooth; Nicotine; Papaverine; Parasympathomimetics; Plant Extracts; Procaine; Pyrans; Serotonin

1969
[Relationship between chemical structure, physio-chemical properties, chemical reactivity and effect of various local anesthetics with position isomerism. 31. 1].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:12

    Topics: Acetanilides; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Animals; Anthelmintics; Benzocaine; Binding Sites; Blood Pressure; Chemical Phenomena; Chemistry; Cocaine; Diphenhydramine; Ethylamines; Hydroxides; Isomerism; Lethal Dose 50; Lidocaine; Mice; Procaine; Propylamines; Quaternary Ammonium Compounds; Rabbits; Rats; Structure-Activity Relationship; Sulfanilamides

1974
Comparative study of the effects of procaine, bencain, cocaine, and anesthesin on electrical activity of the node of Ranvier of single frog nerve fibers.
    Bulletin of experimental biology and medicine, 1974, Volume: 76, Issue:12

    Topics: Action Potentials; Anesthetics, Local; Animals; Benzoates; Benzocaine; Calcium; Cell Membrane Permeability; Cocaine; Diethylamines; Lipid Metabolism; Procaine; Rana temporaria; Ranvier's Nodes; Sciatic Nerve; Sodium

1974
Differential spectroscopy of cocaine and its structural analogues in sample characterization.
    African journal of medicine and medical sciences, 1994, Volume: 23, Issue:4

    Topics: Benzoates; Benzocaine; Benzoic Acid; Cocaine; Forensic Medicine; Humans; Spectrophotometry, Ultraviolet; Substance Abuse Detection

1994
Contrasting actions of cocaine, local anaesthetic and tetrodotoxin on discharge properties of rat aortic baroreceptors.
    The Journal of physiology, 1994, Jun-01, Volume: 477, Issue:Pt 2

    Topics: Anesthetics, Local; Animals; Aorta, Thoracic; Benzocaine; Cocaine; Dose-Response Relationship, Drug; In Vitro Techniques; Lidocaine; Male; Pressoreceptors; Pressure; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin

1994
Binding of benzocaine in batrachotoxin-modified Na+ channels. State-dependent interactions.
    The Journal of general physiology, 1994, Volume: 103, Issue:3

    Topics: Animals; Batrachotoxins; Benzocaine; Binding Sites; Cells, Cultured; Chloramines; Cocaine; Electrophysiology; Pituitary Gland; Rats; Sodium; Sodium Channels; Tosyl Compounds

1994
Determination of highest no effect dose (HNED) for local anaesthetic responses to procaine, cocaine, bupivacaine and benzocaine.
    Equine veterinary journal, 1996, Volume: 28, Issue:1

    Topics: Anesthetics, Local; Animals; Benzocaine; Body Temperature; Bupivacaine; Cocaine; Dose-Response Relationship, Drug; Female; Horses; Hot Temperature; Image Processing, Computer-Assisted; Procaine; Time Factors

1996
Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Animals; Benzocaine; Binding, Competitive; Carrier Proteins; Cations; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Hydrogen-Ion Concentration; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Synaptosomes

1996
Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics.
    Molecular pharmacology, 1998, Volume: 54, Issue:4

    Topics: Anesthetics, Local; Animals; Benzocaine; Binding Sites; Cells, Cultured; Cocaine; Humans; Kinetics; Lysine; Membrane Potentials; Mutagenesis, Site-Directed; Point Mutation; Rats; Sodium Channel Blockers; Sodium Channels

1998
Redox properties of local anesthetics: A structural determinant of closed channel blockers in BTX-modified Na+ channels.
    Membrane & cell biology, 2001, Volume: 14, Issue:4

    Topics: Anesthetics, Local; Batrachotoxins; Benzocaine; Cell Membrane; Cocaine; Electrons; Eosine Yellowish-(YS); Fluorescent Dyes; Hemin; Ligands; Light; Models, Biological; Molecular Structure; Oxidation-Reduction; Protein Structure, Secondary; Sodium Channels; Tetracaine

2001
CLINICAL EFFECTIVENESS OF DRUGS USED FOR TOPICAL ANESTHESIA.
    JAMA, 1964, May-25, Volume: 188

    Topics: Anesthesia, Local; Anesthetics; Anesthetics, Local; Benzocaine; Cocaine; Dibucaine; Electric Stimulation; Humans; Lidocaine; Lip; Mepivacaine; Mucous Membrane; Palate; Pharmacology; Procaine; Sympathomimetics; Tetracaine; Tongue; Treatment Outcome; Tripelennamine

1964
White powder, blue patient: methaemoglobinaemia associated with benzocaine-adulterated cocaine.
    Resuscitation, 2010, Volume: 81, Issue:1

    Topics: Adult; Benzocaine; Cocaine; Drug Contamination; Humans; Illicit Drugs; Male; Methemoglobinemia; Skin Pigmentation

2010
Thin layer chromatography coupled to paper spray ionization mass spectrometry for cocaine and its adulterants analysis.
    Forensic science international, 2016, Volume: 262

    Topics: Benzocaine; Caffeine; Chromatography, Thin Layer; Cocaine; Drug Contamination; Humans; Lidocaine; Mass Spectrometry; Narcotics; Phenacetin

2016
Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule.
    The Analyst, 2021, Mar-07, Volume: 146, Issue:5

    Topics: Benzocaine; Cocaine; Electrochemical Techniques; Electrodes; Molecular Imprinting; Molecularly Imprinted Polymers; Polymers

2021
Reagentless Voltammetric Identification of Cocaine from Complex Powders.
    Analytical chemistry, 2022, 09-20, Volume: 94, Issue:37

    Topics: Benzocaine; Caffeine; Carbon Fiber; Cocaine; Levamisole; Lidocaine; Powders; Procaine; Water

2022