cocaine and 8-hydroxynorcocaine

cocaine has been researched along with 8-hydroxynorcocaine in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's5 (45.45)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alroy, J; Powers, JF; Shuster, L1
Reith, ME; Wiener, HL1
Benuck, M; Lajtha, A; Reith, ME1
Kloss, MW; Rauckman, EJ; Rosen, GM2
Freeman, RW; Harbison, RD; Teaf, CM1
Casey, E; Shuster, L; Welankiwar, SS1
Lloyd, RV; Mason, RP; Shuster, L1
Evans, JE; Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR1
Bornheim, LM1
Boelsterli, UA; Boess, F; Ndikum-Moffor, FM; Roberts, SM1

Other Studies

11 other study(ies) available for cocaine and 8-hydroxynorcocaine

ArticleYear
Hepatic morphologic and biochemical changes induced by subacute cocaine administration in mice.
    Toxicologic pathology, 1992, Volume: 20, Issue:1

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Ribosomes

1992
Differential effects of daily administration of cocaine on hepatic and cerebral glutathione in mice.
    Biochemical pharmacology, 1990, Oct-15, Volume: 40, Issue:8

    Topics: Amino Acids; Animals; Aspartate Aminotransferases; Brain; Cocaine; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Peptides

1990
Presence of the toxic metabolite N-hydroxy-norcocaine in brain and liver of the mouse.
    Biochemical pharmacology, 1988, Mar-15, Volume: 37, Issue:6

    Topics: Animals; Brain Chemistry; Chloramphenicol; Cocaine; Diazinon; Liver; Male; Mice; Mice, Inbred BALB C

1988
Biotransformation of norcocaine to norcocaine nitroxide by rat brain microsomes.
    Psychopharmacology, 1984, Volume: 84, Issue:2

    Topics: Animals; Biotransformation; Brain; Cocaine; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains

1984
Initiation of in vitro lipid peroxidation by N-hydroxynorcocaine and norcocaine nitroxide.
    Molecular pharmacology, 1982, Volume: 22, Issue:3

    Topics: Animals; Cocaine; Cricetinae; Electron Spin Resonance Spectroscopy; Free Radicals; In Vitro Techniques; Kinetics; Lipid Peroxides; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; NADP; Rats; Rats, Inbred F344; Species Specificity

1982
Cocaine-induced hepatotoxicity: lipid peroxidation as a possible mechanism.
    Drug and chemical toxicology, 1984, Volume: 7, Issue:4

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Lipid Peroxides; Male; Malondialdehyde; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital

1984
Metabolism of cocaine and norcocaine to N-hydroxynorcocaine.
    Biochemical pharmacology, 1983, Oct-15, Volume: 32, Issue:20

    Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme Inhibitors; Male; Mass Spectrometry; Mice; Microsomes

1983
Reexamination of the microsomal transformation of N-hydroxynorcocaine to norcocaine nitroxide.
    Molecular pharmacology, 1993, Volume: 43, Issue:4

    Topics: Animals; Biotransformation; Brain; Cocaine; Electron Spin Resonance Spectroscopy; Female; In Vitro Techniques; Lipid Peroxides; Male; Microsomes; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Superoxides

1993
Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.
    Pharmacology, 1993, Volume: 46, Issue:5

    Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases

1993
Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity.
    Toxicology and applied pharmacology, 1998, Volume: 150, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoenzymes; Liver; Male; Mice; Narcotics; Phencyclidine; Phenobarbital

1998
Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species.
    Biochemical pharmacology, 2000, Sep-01, Volume: 60, Issue:5

    Topics: Animals; Cell Respiration; Cocaine; Dopamine Uptake Inhibitors; In Vitro Techniques; Mice; Mice, Inbred ICR; Mitochondria; Reactive Oxygen Species; Rhodamines

2000