cocaine has been researched along with 6-methyl-2-(phenylethynyl)pyridine in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McGeehan, AJ; Olive, MF | 1 |
| Boutrel, B; Gasparini, F; Harrison, AA; Kenny, PJ; Koob, GF; Markou, A; Paterson, NE; Semenova, S; Skoubis, PD | 1 |
| Janak, PH; Mcgeehan, AJ; Olive, MF | 1 |
| Andreoli, M; Heidbreder, CA; Hutcheson, DM; Pilla, M; Tessari, M | 1 |
| Adewale, AS; Lee, B; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Herzig, V; Schmidt, WJ | 1 |
| Boutrel, B; Gasparini, F; Kenny, PJ; Koob, GF; Markou, A | 1 |
| Markou, A; Paterson, NE | 1 |
| Capuani, EM; Herzig, V; Kovar, KA; Schmidt, WJ | 1 |
| Bäckström, P; Hyytiä, P | 1 |
| Brownell, AL; Cicchetti, F; Pellegrino, D; Saint-Pierre, M; Wang, X; Yu, M; Zhu, A | 1 |
| Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Hillard, CJ; Liu, QS; Pan, B | 1 |
| Anderson, SM; Famous, KR; Kumaresan, V; Pierce, RC; Schmidt, HD; Yee, J; Yuan, M | 1 |
| Bruckmann, W; De Vry, J; Rutten, K; Tzschentke, TM; Van Der Kam, EL | 1 |
| Dong, Y; Grace, AA; Huang, YH; Ishikawa, M; Neumann, PA; Otaka, M; Schlüter, OM; Winters, BD | 1 |
| Bi, GH; Gardner, EL; Keck, TM; Newman, AH; Srivastava, R; Wang, XF; Xi, ZX; Yang, HJ; Zhang, HY; Zou, MF | 1 |
| Diberto, JF; Fish, EW; Krouse, MC; Malanga, CJ; Robinson, JE; Stringfield, SJ | 1 |
| Arreola, AC; Kimmey, BA; Pierce, RC; Schmidt, HD | 1 |
| Martinez, LA; Meisel, RL; Mermelstein, PG; Peterson, BM | 1 |
| Hsu, KS; Huang, CC; Lee, CC; Liang, YC | 1 |
| Hasler, G; Mihov, Y | 1 |
| Bi, GH; Gardner, EL; He, Y; Jordan, CJ; Li, J; Li, X; Peng, XQ; Xi, ZX; Yang, HJ; Zhang, HY | 1 |
1 review(s) available for cocaine and 6-methyl-2-(phenylethynyl)pyridine
| Article | Year |
|---|---|
Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.
Topics: Allosteric Regulation; Animals; Cocaine; Drug-Seeking Behavior; Ethanol; Nicotine; Pyridines; Receptor, Metabotropic Glutamate 5; Self Administration; Substance-Related Disorders; Thiazoles | 2016 |
22 other study(ies) available for cocaine and 6-methyl-2-(phenylethynyl)pyridine
| Article | Year |
|---|---|
The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.
Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Illicit Drugs; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Narcotics; Nicotine; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward | 2003 |
Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Tobacco Use Disorder | 2003 |
Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Cocaine; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Male; Mice; Mice, Inbred DBA; Motor Activity; Piperazines; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2004 |
Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Injections, Intravenous; Male; Motor Activity; Nicotine; Psychomotor Performance; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Secondary Prevention; Self Administration; Substance-Related Disorders | 2004 |
Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine.
Topics: Animals; Behavior, Animal; Cocaine; Discrimination Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Male; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Saimiri; Self Administration | 2005 |
Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine.
Topics: Animals; Body Weight; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Learning; Male; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Reward | 2004 |
Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats.
Topics: Animals; Brain; Choice Behavior; Cocaine; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Male; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Self Administration; Self Stimulation | 2005 |
The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats.
Topics: Animals; Cocaine; Excitatory Amino Acid Antagonists; Food; Male; Motivation; Nicotine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement, Psychology; Self Administration | 2005 |
Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats.
Topics: Amphetamine; Animals; Choice Behavior; Cocaine; Conditioning, Psychological; Feeding Behavior; Locomotion; Male; N-Methyl-3,4-methylenedioxyamphetamine; Pyridines; Rats; Rats, Sprague-Dawley; Reward; Serotonin Agents | 2005 |
Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Male; Motor Activity; Nucleus Accumbens; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Self Administration | 2007 |
Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats.
Topics: Animals; Carbon Radioisotopes; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Hippocampus; Immunohistochemistry; Male; Nerve Degeneration; Neurons; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Pyridines; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine.
Topics: Animals; Behavior, Animal; Cocaine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Saimiri; Self Administration | 2008 |
D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Chromones; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Drug Combinations; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mesencephalon; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2 | 2008 |
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.
Topics: Animals; Catheterization; Cocaine; Cocaine-Related Disorders; Cues; Dietary Sucrose; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Male; Microinjections; Nucleus Accumbens; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Self Administration; Thiazoles | 2009 |
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats.
Topics: Animals; Brain; Buspirone; Choice Behavior; Clonidine; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Synergism; Illicit Drugs; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Social Environment; Substance-Related Disorders | 2011 |
Dopamine triggers heterosynaptic plasticity.
Topics: Analysis of Variance; Animals; Benzoates; Channelrhodopsins; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; GABAergic Neurons; Genetic Vectors; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Long-Term Synaptic Depression; Male; Nucleus Accumbens; Optogenetics; Phosphinic Acids; Photic Stimulation; Propanolamines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Synapses; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2013 |
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Binding, Competitive; Cocaine; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Imidazoles; In Vitro Techniques; Infusions, Intravenous; Inhibitory Concentration 50; Male; Motor Activity; Nitriles; Piperidines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5; Reinforcement Schedule; Reward; Secondary Prevention; Self Administration; Sucrose; Thiazoles | 2014 |
Changes in sensitivity of reward and motor behavior to dopaminergic, glutamatergic, and cholinergic drugs in a mouse model of fragile X syndrome.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Blotting, Western; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; Immunoenzyme Techniques; Male; Mice; Mice, Knockout; Motor Activity; Muscarinic Antagonists; Piperazines; Pyridines; Quinolones; Receptor, Metabotropic Glutamate 5; Reward; Trihexyphenidyl; Tyrosine 3-Monooxygenase | 2013 |
Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.
Topics: Animals; Benzimidazoles; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Nucleus Accumbens; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Thiazoles | 2015 |
Estradiol facilitation of cocaine-induced locomotor sensitization in female rats requires activation of mGluR5.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Estradiol; Estrogens; Excitatory Amino Acid Antagonists; Female; Locomotion; Ovariectomy; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Inhibition; Receptor, Metabotropic Glutamate 5; Weight Gain | 2014 |
Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways.
Topics: Animals; Benzamides; Chromones; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genes, Reporter; Glycine; Imidazoles; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nucleus Accumbens; Pyrazoles; Pyridazines; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; Resorcinols; Substance Withdrawal Syndrome | 2015 |
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism.
Topics: Animals; Cocaine; Dopamine; Drug-Seeking Behavior; Glutamic Acid; Male; Nucleus Accumbens; Pyridines; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Self Administration | 2018 |