Compounds > cocaine

cocaine and 6-chloro-2-(1-piperazinyl)pyrazine

cocaine has been researched along with 6-chloro-2-(1-piperazinyl)pyrazine in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (14.29)	18.7374
1990's	5 (35.71)	18.2507
2000's	5 (35.71)	29.6817
2010's	1 (7.14)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP	1
Bethea, CL; Brownfield, MS; Carnes, M; Lent, SJ; O'Connor, P; Palionis, T; Rittenhouse, PA; Van de Kar, LD	1
Alvarez Sanz, MC; Brownfield, MS; Levy, AD; Li, Q; Rittenhouse, PA; Van de Kar, LD	1
Appel, JB; White, FJ	1
Lee, MA; Meltzer, HY	1
Meltzer, HY; Willins, DL	1
George, FR; Kreifeldt, MJ; O'Dell, LE; Ritz, MC	1
Cunningham, KA; Filip, M	2
Bubar, MJ; Cunningham, KA; Filip, M	1
Acosta, JI; Neisewander, JL	1
Cunningham, KA; dela Cruz, AM; Grady, JJ; Herin, DV	1
Conway, SM; Neisewander, JL; Pentkowski, NS; Pockros, LA; Ullman, TE; Zwick, KR	1
Arenas, MC; Manzanedo, C; Mateos-García, A; Miñarro, J	1

Trials

1 trial(s) available for cocaine and 6-chloro-2-(1-piperazinyl)pyrazine

Article	Year
Blunted oral body temperature response to MK-212 in cocaine addicts. Drug and alcohol dependence, 1994, Volume: 35, Issue:3 Topics: Adult; Body Temperature Regulation; Cocaine; Humans; Hydrocortisone; Male; Prolactin; Pyrazines; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Substance-Related Disorders	1994

Other Studies

13 other study(ies) available for cocaine and 6-chloro-2-(1-piperazinyl)pyrazine

Article	Year
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship	1989
Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. Biological psychiatry, 1992, Aug-01, Volume: 32, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Arousal; Brain; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Hormones; Injections, Intraperitoneal; Male; Neurosecretory Systems; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Renin; Synaptic Transmission; Vasopressins	1992
Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI. European journal of pharmacology, 1992, Oct-06, Volume: 221, Issue:1 Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Cocaine; Corticosterone; Hormones; Male; Oxytocin; Prolactin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Renin; Serotonin Receptor Agonists	1992
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology, 1981, Volume: 73, Issue:2 Topics: Animals; Cocaine; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Hallucinogens; Lisuride; Lysergic Acid Diethylamide; Male; p-Chloroamphetamine; Piperazines; Pyrazines; Quipazine; Rats; Serotonin; Serotonin Antagonists	1981
Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain research, 1998, Jan-19, Volume: 781, Issue:1-2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Microdialysis; Morphine; Narcotic Antagonists; Nucleus Accumbens; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists	1998
Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions. Psychopharmacology, 1999, Volume: 146, Issue:3 Topics: Animals; Cocaine; Male; Mice; Mice, Inbred C57BL; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Seizures; Species Specificity	1999
Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior, 2002, Volume: 71, Issue:4 Topics: Animals; Cocaine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylamines; Hyperkinesis; Indoles; Male; Microinjections; Motor Activity; Nucleus Accumbens; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides	2002
Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2 Topics: Animals; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride; Spiro Compounds; Sulfonamides	2003
Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3 Topics: Amphetamines; Animals; Cocaine; Drug Interactions; Fluorobenzenes; Hyperkinesis; Indoles; Male; Phenols; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes	2004
Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats. Behavioural pharmacology, 2007, Volume: 18, Issue:8 Topics: Aminopyridines; Animals; Behavior, Addictive; Cocaine; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Indoles; Male; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Self Administration	2007
Novel approach to data analysis in cocaine-conditioned place preference. Behavioural pharmacology, 2009, Volume: 20, Issue:8 Topics: Animals; Benzazepines; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Models, Animal; N-Methyl-3,4-methylenedioxyamphetamine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serotonin Receptor Agonists; Time Factors	2009
5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen. Synapse (New York, N.Y.), 2012, Volume: 66, Issue:12 Topics: Animals; Caudate Nucleus; Cocaine; Fluorobenzenes; Gene Expression Regulation; Locomotion; Male; Piperidines; Proto-Oncogene Proteins c-fos; Putamen; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists	2012
The negative allosteric modulator of mGluR5, MPEP, potentiates the rewarding properties of cocaine in priming-induced reinstatement of CPP. Adicciones, 2020, Jul-01, Volume: 32, Issue:3 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Extinction, Psychological; Female; Male; Mice; Pyrazines; Receptor, Metabotropic Glutamate 5	2020