cocaine has been researched along with (3h)2-carbomethoxy-3-(4-fluorophenyl)tropane in 390 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (2.05) | 18.7374 |
1990's | 184 (47.18) | 18.2507 |
2000's | 158 (40.51) | 29.6817 |
2010's | 38 (9.74) | 24.3611 |
2020's | 2 (0.51) | 2.80 |
Authors | Studies |
---|---|
D'Mello, GD; Goldberg, DM; Goldberg, SR; Stolerman, IP | 2 |
Gehlert, DR; Schoepp, DD | 1 |
Reith, ME; Selmeci, G | 2 |
Boja, JW; Carroll, FI; Kuhar, MJ; Rostène, W; Scherman, D | 1 |
Hitzemann, R; Svingos, AL | 1 |
Kaufman, MJ; Madras, BK | 3 |
Reith, ME; Wiener, HL | 1 |
Inosaka, T; Numachi, Y; Sato, M; Yoshida, S | 1 |
Boja, JW; Kuhar, MJ; Markham, L; Patel, A; Uhl, G | 1 |
Brownell, AL; Brownell, GL; Elmaleh, D; Hantraye, P; Isacson, O; Madras, BK; Spealman, RD; Wüllner, U | 1 |
Kuhar, MJ; Lew, R; Patel, A; Vaughan, RA; Wilson, A | 1 |
Boja, JW; Carroll, FI; Cline, EJ; Katz, JL; Kuhar, MJ; Scheffel, U | 1 |
Aloyo, VJ; Harvey, JA; Kirifides, AL | 1 |
Abraham, P; Boja, JW; Carroll, FI; Gao, Y; Kuhar, MJ; Lew, R; Lewin, AH; Patel, A | 1 |
Bergman, J; Madras, BK; Melia, KF; Spealman, RD | 1 |
Bergman, J; Madras, BK; Spealman, RD | 1 |
Kaufman, MJ; Madras, BK; Spealman, RD | 1 |
Kuhar, MJ; Lew, R; Simantov, R; Vaughan, RA | 1 |
Kuhar, MJ; Pögün, S; Scheffel, U | 1 |
Rudnick, G; Wall, SC | 1 |
Gregor, P; Kitayama, S; Kuhar, M; Lin, CL; Nanthakumar, E; Patel, A; Shimada, S; Uhl, G | 1 |
Abraham, P; Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Parham, K | 1 |
Madras, BK; Milius, RA; Neumeyer, JL; Saha, JK | 1 |
Boja, JW; Kuhar, MJ; Pögün, S; Scheffel, U; Stathis, M | 1 |
Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Philip, A; Rahman, MA | 1 |
Canfield, DR; Kaufman, MJ; Madras, BK; Spealman, RD | 1 |
Canfield, DR; Fahey, MA; Kamien, JB; Madras, BK; Milius, RA; Neumeyer, JL; Saha, JK; Spealman, RD | 1 |
Heikkila, RE; Nicklas, WJ; Ofori, S | 1 |
Boja, JW; Kuhar, MJ; Scheffel, U | 1 |
Fahey, MA; Madras, BK; Milius, RA; Neumeyer, JL; Saha, JK; Spealman, RD | 1 |
Heikkila, RE; Kindt, MV; Mayer, RA | 1 |
Lajtha, A; Reith, ME; Sershen, H | 1 |
Järbe, TU | 1 |
Boja, JW; Carroll, FI; Kuhar, MJ; Lever, SZ; Scheffel, U; Stathis, M | 1 |
Allen, AC; George, C; Izenwasser, S; Katz, JL; Kline, RH; Newman, AH | 1 |
Chen, R; Ding, YS; Fowler, JS; Gatley, SJ; Sugano, Y; Volkow, ND | 1 |
Brownell, AL; Brownell, GL; Elmaleh, DR; Liang, AY; Madras, BK; Meltzer, PC | 1 |
Eshleman, AJ; Janowsky, A; Neve, KA; Neve, RL | 1 |
Kunko, PM; Maher, JR; McDowell, KP; Robinson, SE | 1 |
Boja, JW; Kopajtic, TA | 1 |
Coen, KM; Corrigall, WA; Kish, SJ; Nobrega, JN; Shannak, K; Wilson, JM | 1 |
Aloyo, VJ; Harvey, JA; Kirifides, AL; Pazdalski, PS; Ruffin, JS | 1 |
Abraham, P; Boja, JW; Cadet, JL; Carroll, FI; Kopajtic, TA; Lever, J; Lewin, AH; Seltzman, HH; Wyrick, CD | 1 |
Carney, JM; Tolliver, BK | 1 |
Gracz, LM; Madras, BK | 1 |
Heller, B; Izenwasser, S; Katz, JL; Terry, P; Witkin, JM | 1 |
London, ED; Mantione, CR; Ritz, MC | 1 |
Alexoff, DA; Chen, R; Dewey, SL; Ding, YS; Fowler, JS; Gatley, SJ; Pan, D | 1 |
Coffey, LL; Reith, ME; Xu, C | 3 |
Moriwaki, A; Uhl, GR; Wang, JB | 1 |
Eckenhoff, RG; Fagan, D | 1 |
Brownell, AL; Brownell, GL; Burns, L; Elmaleh, D; Hantraye, P; Pakzaban, P; Petto, AJ; Shoup, T; Spealman, RD; Wüllner, U | 1 |
Giovanni, A; Heikkila, RE; Sieber, BA; Sonsalla, PK | 1 |
Giovanni, A; Heikkila, RE; Sonsalla, PK | 1 |
Dohi, T; Kitayama, S; Uhl, GR | 1 |
Hearn, WL; Mash, DC; Ruttenber, AJ; Staley, JK; Wetli, CV | 1 |
Deutsch, HM; Schweri, MM | 1 |
Dutta, AK; Madras, BK; Meltzer, PC; Reith, ME | 1 |
Abraham, P; Boja, JW; Carroll, FI; Gao, Y; Kuhar, MJ; Kuzemko, MA; Lewin, AH; Mascarella, SW | 1 |
Patel, A | 1 |
Madras, BK | 1 |
Isacson, O | 1 |
Goodman, MM; Meyer, MA | 1 |
Carroll, ME; Dixon, LM; Kish, SJ; Lac, ST; Niznik, HB; Nobrega, JN; Pristupa, ZB; Shannak, K; Wilson, JM | 1 |
Coffey, LL; Reith, ME | 3 |
Campbell, AD; Erwin, VG; Jones, BC; Womer, DE | 1 |
Crippen, GM; Srivastava, S | 1 |
Chan, B; Chen, CA; Dannals, RF; Folio, T; Ravert, HT; Ricaurte, GA; Scheffel, U; Shaya, EK; Wong, DF; Yung, B | 1 |
Izenwasser, S; Katz, JL; Newman, AH | 1 |
Hoffman, BJ; Kish, SJ; Niznik, HB; Pristupa, ZB; Wilson, JM | 1 |
Carroll, FI; Clark, TB; Duncan, GE; Kirkman, JA; Little, KY | 1 |
Dannals, RF; Ehlers, MD; Frost, JJ; Ravert, HT; Reich, SG; Rosier, AJ; Smith, JS; Snyder, SH | 1 |
Becketts, KM; Carroll, FI; de Costa, BR; Dersch, CM; Radesca, LR; Rice, KC; Rothman, RB | 1 |
Hanbauer, I; Valchar, M | 1 |
Richfield, EK | 1 |
Cox, BM; Izenwasser, S; Rosenberger, JG | 1 |
Butler, T; Dobbie, JW; Duffield, R; Hjelle, JT; Ho, AK; Miller-Hjelle, MA; Reith, M; Steidley, KR | 1 |
Bergman, DA; Coulter, CL; Happe, HK; Murrin, LC | 1 |
Aloyo, VJ; Harvey, JA; Kirifides, AL; Pazdalski, PS | 1 |
Cody, V; Froimowitz, M; Patrick, KS | 1 |
Laihinen, A; Någren, K; Rinne, JO; Rinne, UK; Ruotsalainen, U; Ruottinen, H | 1 |
Blanc, G; Charnay, Y; de Saint Hilaire, Z; Gaillard, JM; Python, A | 1 |
Chen, NH; Coffey, LL; Reith, ME; Xu, C | 1 |
Kish, SJ; Wilson, JM | 1 |
Deutsch, HM; Gruszecka-Kowalik, E; Schweri, MM; Shi, Q | 1 |
Breese, GR; Bryan, RN; Dannals, RF; Evans, A; Gjedde, A; Harris, JC; Kuhar, MJ; Marenco, S; Naidu, S; Ravert, HT; Rousset, O; Wong, DF; Yaster, M; Yokoi, F | 1 |
Aronson, B; Enmon, JL; Izenwasser, S; Katz, JL; Kelkar, SV; Luo, L; Nolan, SP; Trudell, ML | 1 |
Ciliax, BJ; Lee, FJ; Levey, AI; Niznik, HB; Pristupa, ZB | 1 |
Boja, JW; Ehlers, MD; Kim, SE; Kuhar, MJ; Scheffel, U; Steinert, C | 1 |
Reith, ME; Xu, C | 2 |
Allard, P; Marcusson, JO; Ross, SB | 1 |
Abraham, P; Blough, BE; Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH | 1 |
Cox, BM; Izenwasser, S; Katz, JL; Newman, AH | 1 |
Bergman, J; Haaparanta, M; Hietala, J; Laakso, A; Solin, O | 1 |
Carroll, FI; Fleckenstein, AE; Kuhar, MJ; Pögün, S | 1 |
Abraham, P; Boja, JW; Carroll, FI; Holmquist, CR; Keverline-Frantz, KI; Kuhar, MJ | 1 |
Abraham, P; Boja, JW; Carroll, FI; Lewin, AH; Mash, DC; Seltzman, HH; Staley, JK; Wyrick, CD | 1 |
Boja, JW; Carroll, FI; Fleckenstein, AE; Kopajtic, TA; Kuhar, MJ | 1 |
Altman-Hamamdzic, S; Arnaud, P; Ma, JX; Parratto, NP; Sallee, FR; Vrindavanam, NS | 1 |
Alpert, NM; Babich, JW; Bonab, AA; Christian, BT; Fischman, AJ; Hsu, H; Livni, E; Madras, BK; Morris, ED; Weise, S | 1 |
Flores, G; Liang, JJ; Quirion, R; Srivastava, LK; Wood, GK | 1 |
Darmani, NA; Reeves, SL | 1 |
Boja, JW; Houlihan, WJ; Kopajtic, TA; Kuhar, MJ; Parrino, VA | 1 |
Apostolakis, EM; Clark, JH; Garai, J; O'Malley, BW | 1 |
Brownell, AL; Brownell, GL; Elmaleh, DR; Fischman, AJ; Madras, BK; Meltzer, PC; Shoup, TM | 1 |
Byon, C; Elmaleh, DR; Fischman, AJ; Hanson, RN; Liang, AY; Madras, BK; Meltzer, PC; Shoup, TM | 1 |
Reith, ME; Zhang, L | 1 |
Glowa, JR; Wojnicki, FH | 1 |
Halldin, C; Lehikoinen, P; Müller, L; Någren, K; Swahn, CG | 1 |
Coffey, LL; Dutta, AK; Reith, ME | 1 |
Descarries, L; Doucet, G; Lafaille, F; Mrini, A; Soucy, JP | 1 |
Bowen, WD; Izenwasser, S; Joseph, DB; Katz, JL; Kline, RH; Newman, AH | 1 |
Izenwasser, S; Katz, JL; Kelkar, SV; Kline, RH; Lomenzo, SA; Trudell, ML; Xu, L | 1 |
Chang, LJ; el-Awar, M; Guttman, M; Kish, SJ; Levey, AI; Robitaille, Y | 1 |
Coffey, LL; Reith, ME; Zhang, L | 1 |
Avor, KS; Basmadjian, GP; Pouw, B; Seale, TW; Singh, S | 1 |
Coffey, LL; Reith, ME; Wu, Q | 1 |
Ding, YS; Fowler, JS; Gatley, SJ; Volkow, ND; Wang, GJ | 1 |
Gjedde, A; Gründer, G; Harris, J; Kuhar, M; Naidu, S; Ricaurte, G; Rothman, R; Singer, H; Szymanski, S; Villemagne, V; Wong, DF; Yokoi, F | 1 |
Jackson, PF; Olkowski, JL; Slusher, BS; Tiffany, CW | 1 |
Ashworth, S; Brown, DJ; Hirani, E; Hume, SP; Lammertsma, AA; Luthra, SK | 1 |
Beal, MF; Bogdanov, M; Brownell, AL; Chen, YC; Galpern, WR; Isacson, O; Jenkins, BG; Keltner, JR; Matthews, RT; Rosen, BR | 1 |
Izenwasser, S; Kunko, PM; Loeloff, RJ | 1 |
Dannals, RF; Hatzidimitriou, G; Mathews, WB; McCann, UD; Musachio, J; Ravert, HT; Ricaurte, GA; Villemagne, V; Wong, DF; Yuan, J | 1 |
Cunningham, VJ; Gunn, RN; Hume, SP; Lammertsma, AA | 1 |
Avor, K; Basmadjian, GP; Chan, HM; Hall, N; Seale, TW; Singh, S | 1 |
Geter-Douglass, B; Tirelli, E; Witkin, JM | 1 |
Agoston, GE; George, C; Izenwasser, S; Katz, J; Kline, RH; Newman, AH; Wu, JH | 1 |
Bowen, WD; Husbands, SM; Izenwasser, S; Katz, JL; Loeloff, RJ; Newman, AH; Vilner, BJ | 1 |
Izenwasser, S; Katz, JL; Klein, CL; Lomenzo, SA; Terry, PD; Trudell, ML; Zhu, N | 1 |
Lehikoinen, P; Någren, K; Rinne, JO; Ruottinen, H; Sahlberg, N | 1 |
Ding, YS; Fowler, JS; Gatley, SJ; King, P; Logan, J; Pappas, N; Volkow, ND; Wang, GJ | 1 |
Abraham, P; Boja, JW; Burgess, JP; Carroll, FI; Keverline-Frantz, KI; Kuhar, MJ; Lewin, AH | 1 |
Coulter, CL; Happe, HK; Murrin, LC | 1 |
Gunn, RN; Hume, SP; Jones, T | 1 |
Bergman, J; Haaparanta, M; Hietala, J; Laakso, A; Solin, O; Vilkman, H | 1 |
Allard, P; Norlén, M | 1 |
Babich, J; Elmaleh, DR; Fischman, AJ; Liang, AY; Madras, BK; Meltzer, PC | 1 |
Araldi, GL; Boja, J; Flippen-Anderson, JL; George, C; Johnson, KM; Kozikowski, AP; Meil, WM; Saiah, E | 1 |
Izenwasser, S; Katz, JL; Terry, PD; Trudell, ML; Zhang, C | 1 |
Frederiksen, D; Gether, U; Nielsen, EO; Norregaard, L | 1 |
Ferrer, JV; Javitch, JA | 1 |
Dutta, AK; Reith, ME; Xu, C | 1 |
Lee, FJ; Liu, F; Man, HY; McConkey, F; Niznik, HB; Pristupa, ZB; Wang, YT | 1 |
Elmer, LW; Little, KY; Zhang, L | 1 |
Dannals, RF; McCann, UD; Ricaurte, GA; Villemagne, V; Wong, DF; Yokoi, F | 1 |
Bonnet, JJ; Corera, AT; Do Régo, JC | 1 |
Carroll, FI; Chen, NH; Reith, ME; Xu, C | 1 |
Berger, R; Brust, P; Hoepping, A; Johannsen, B; Leibnitz, P; Machill, S; Scheller, D; Spies, H | 1 |
Allen, AC; Izenwasser, S; Katz, JL; Kline, RH; Newman, AH | 1 |
Fleckenstein, AE; Hanson, GR; Kokoshka, JM; Vaughan, RA | 1 |
Harvey, DC; Huang, SC; Lacan, G; Melega, WP; Phelps, ME | 1 |
Dickinson, SD; Gerhardt, GA; Giardina, K; Grandy, DK; Kelly, MA; Larson, GA; Low, MJ; Rubinstein, M; Sabeti, J; Zahniser, NR | 1 |
Brashear, A; Farlow, MR; Hutchins, GD; Mulholland, GK; Siemers, ER; Zheng, QH | 1 |
Berfield, JL; Reith, ME; Wang, LC | 1 |
Cassin, BJ; Dalack, GW; Desmond, T; Frey, KA; Little, KY; Zhang, L | 1 |
Bergman, J; Eronen, E; Haaparanta, M; Oikonen, V; Rinne, JO; Ruottinen, H; Solin, O; Sonninen, P | 1 |
Gerhardt, GA; Hebert, MA; Larson, GA; Zahniser, NR | 1 |
Li, LB; Reith, ME | 2 |
Deutsch, H; Schenk, JO; Schweri, MM; Wayment, HK | 1 |
Burnham, KS; Collard, DM; Deshpande, AK; Deutsch, HM; Holtzman, SG; Schweri, MM; Zhang, L | 1 |
Chang, AS; Chang, SM | 1 |
Dannals, RF; Matecka, D; Rice, KC; Rothman, RB; Villemagne, VL; Wong, DF; Yokoi, F | 1 |
Blakely, RD; Jansen, K; Richelson, E; Tatsumi, M | 1 |
Dresel, SH; Hou, C; Huang, XF; Kung, HF; Kung, MP; Meegalla, SK; Mu, M; Patselas, G; Plössl, K; Saffer, JR | 1 |
Dannals, RF; Frost, JJ; Ilgin, N; Ravert, HT; Reich, SG; Zubieta, J | 1 |
Futatsubashi, M; Iyo, M; Okada, H; Ouchi, Y; Sakamoto, M; Sekine, Y; Yoshikawa, E | 1 |
Guilarte, TR; Kuhlmann, AC | 1 |
Brownell, AL; Isacson, O; Jenkins, BG | 1 |
Corera, AT; Costentin, J; Deslandes, A; Vaugeois, JM | 1 |
Belej, T; Gernert, M; Löscher, W; Nobrega, JN; Raymond, R; Richter, A | 1 |
Dewar, KM; Paquet, M; Sequeira, A | 1 |
Carroll, FI; Garrett, BE; Hunter, RG; Kuhar, MJ; Lambert, PD; McGirr, KM | 1 |
Izenwasser, S; Kline, RH; Newman, AH; Robarge, MJ | 1 |
Chen, A; Cumming, P; Dagher, A; Deep, P; Gjedde, A; Kapczinski, F; Reutens, D; Wong, DF; Yokoi, F | 1 |
Beal, MF; Bogdanov, M; Brownell, AL; Chen, YI; Galpern, W; Isacson, O; Jenkins, BG; Livni, E; Rosen, BR | 1 |
Futatsubashi, M; Kanno, T; Nobezawa, S; Okada, H; Ouchi, Y; Sakamoto, M; Torizuka, T; Yoshikawa, E | 1 |
Dewar, KM | 1 |
Collard, DM; Deutsch, HM; Javanmard, S; Kuhar, MJ; Schweri, MM | 1 |
Harada, N; Kakiuchi, T; Nakanishi, S; Nishiyama, S; Ohba, H; Sato, K; Tsukada, H | 1 |
Gether, U; Loland, CJ; Norregaard, L | 3 |
Blundell, P; Gonzalez, MD; Liang, AY; Madras, BK; Meltzer, PC; Niznik, HB; Pristupa, ZB | 1 |
Desalles, AA; Lacan, G; Melega, WP; Phelps, ME | 1 |
Berciano, J; Figols, J; González, AM; Pascual, J; Pazos, A | 1 |
Izenwasser, S; Katz, JL; Terry, P | 1 |
Alakare, B; Bergman, J; Haaparanta, M; Hietala, J; Laakso, A; Peurasaari, J; Räkköläinen, V; Solin, O; Syvälahti, E; Vilkman, H | 1 |
Bergman, J; Hietala, J; Kajander, J; Laakso, A; paranta, M; Solin, O; Vilkman, H | 1 |
Futatsubashi, M; Homma, Y; Ishii, SI; Ishiwata, K; Kawamura, K; Ouchi, Y; Senda, M | 1 |
Brownell, AL; Cavagna, F; Coyle, JT; Iris Chen, YC; Jenkins, BG; Livni, E; Nguyen, TV; Rosen, BR | 1 |
Barrio, JR; Huang, SC; Namavari, M; Nguyen, Q; Petric, A; Satyamurthy, N; Stout, D | 1 |
Carroll, FI; Kimmel, HL; Kuhar, MJ | 1 |
Blundell, P; Huang, H; Liu, S; Madras, BK; Meltzer, PC; Yong, YF | 1 |
Itokawa, M; Lin, Z; Uhl, GR | 1 |
German, DC; Hogan, KA; Liang, CL; Sonsalla, PK; Staal, RG | 1 |
Callahan, B; Hatzidimitriou, G; Kim, S; Ricaurte, GA; Westphalen, R; Yuan, J | 1 |
Chang, MY; Chin, HR; Lee, KH; Lee, SH; Lee, YS; Park, BS | 1 |
Cai, NS; Itokawa, M; Kitayama, S; Lin, Z; Uhl, GR; Wang, JB; Wu, C | 1 |
Bergman, J; Haaparanta, M; Kaasinen, V; Nurmi, E; Rinne, JO; Ruottinen, HM; Solin, O | 1 |
Stoessl, AJ; Van Kampen, JM | 1 |
Fukumoto, D; Harada, N; Kakiuchi, T; Nishiyama, S; Ohba, H; Sato, K; Tsukada, H | 1 |
McGeer, EG; Stoessl, AJ; Van Kampen, JM | 1 |
Partridge, B; Schenk, S; Shippenberg, TS | 1 |
Davidson, C; Douglas, SB; Ellinwood, EH; Lee, TH | 1 |
Harada, N; Kakiuchi, T; Nishiyama, S; Ohba, H; Tsukada, H | 1 |
Bonnet, JJ; Corera, AT; Costentin, J | 1 |
Berfield, JL; Carroll, FI; Kuhar, MJ; Reith, ME; Wang, LC | 1 |
Dannals, RF; Hilton, J; Ravert, HT; Szabo, Z; Wong, DF; Yokoi, F | 1 |
Bergman, J; Eskola, O; Hinkka, SM; Nurmi, E; Rinne, JO; Solin, O; Sonninen, P | 1 |
Araujo, DM; Cherry, SR; Kornblum, HI; Tatsukawa, KJ; Toyokuni, T | 1 |
Lin, Z; Uhl, GR; Wang, W | 1 |
Mayfield, RD; Zahniser, NR | 1 |
Fleckenstein, AE; Hanson, GR; Riddle, EL; Sandoval, V; Ugarte, YV | 1 |
Dutta, AK; Madras, BK; Reith, ME | 1 |
Ferrer, JV; Javitch, JA; Justice, JB; Whitehead, RE | 1 |
Doolen, S; Zahniser, NR | 1 |
Bonnet, JJ; Costentin, J; Do-Régo, JC; Tidjane Corera, A | 1 |
Hansen, SH; Jensen, AG; Nielsen, EO | 1 |
Futatsubashi, M; Kanno, T; Nobezawa, S; Okada, H; Ouchi, Y; Tanaka, K; Torizuka, T; Yoshikawa, E | 1 |
Bergman, J; Eskola, O; Nurmi, E; Rinne, OJ; Ruottinen, HM; Solin, O | 1 |
Friedman, DP; Letchworth, SR; Nader, MA; Porrino, LJ; Smith, HR | 1 |
Agoston, GE; Alling, KL; Forster, MJ; Katz, JL; Kline, RH; Kopajtic, TA; Newman, AH; Woolverton, WL | 1 |
Kimmel, H; Kuhar, MJ; Vicentic, A | 1 |
Chen, N; Reith, ME; Vaughan, RA | 1 |
Kida, T; Suzuki, K; Takei, M | 1 |
Berfield, JL; Ferrer, JV; Javitch, JA; Reith, ME; Wang, LC | 1 |
Deutsch, HM; Liu, Z; Schweri, MM; Shi, Q; Ye, X | 1 |
Futatsubashi, M; Iyo, M; Matsunaga, T; Mori, N; Okada, H; Ouchi, Y; Sekine, Y; Takei, N; Tsukada, H; Yoshikawa, E | 1 |
Balu, R; Davidson, C; Ellinwood, EH; Lee, TH | 1 |
Davis, MC; Dutta, AK; Reith, ME | 1 |
Cui, D; Ding, J; Fei, J; Guo, L; Liu, Z; Mei, Z; Wang, Y; Zhao, W | 1 |
Stavale, JN; Villares, JC | 1 |
Bergman, J; Haaparanta, M; Hietala, J; Laakso, A; Solin, O; Syvälahti, E; Vilkman, H | 1 |
Avor, KS; Basmadjian, GP; el-Moselhy, TF | 1 |
Chi, DY; Chung, KH; Jin, C; Lee, DR; Lim, CH | 1 |
Cao, J; Husbands, SM; Katz, JL; Kopajtic, T; Newman, AH | 1 |
Justice, JB; Katz, JL; Kopajtic, T; Newman, AH; Wirtz, S; Zou, MF | 1 |
Keller, D; Maiya, R; Mayfield, RD; Zahniser, NR | 1 |
Harada, N; Kakiuchi, T; Nishiyama, S; Ohba, H; Sato, K; Tsukada, H | 1 |
Elmer, LW; Little, KY; Scheys, JO; Zhang, L; Zhong, H | 1 |
Brown, JM; Fleckenstein, AE; Gibb, JW; Hansen, JP; Hanson, GR; Riddle, EL; Sandoval, V | 1 |
Schenk, S | 1 |
Boksa, P; El-Khodor, BF | 1 |
Lin, Z; Uhl, GR | 2 |
Cui, XN; Li, LB; Reith, MA | 1 |
Chang, MY; Jeon, DJ; Lee, CH; Lee, SH; Lee, YS; Oh, DY; Son, H | 1 |
Hearn, WL; Izenwasser, S; Mash, DC; Ouyang, Q; Pablo, J | 1 |
Enyedy, IJ; Johnson, KM; Wang, J; Wang, S; Zaman, WA | 1 |
Chen, N; Reith, ME; Sun, L | 1 |
Fukumoto, D; Harada, N; Kakiuchi, T; Nishiyama, S; Satoh, K; Tsukada, H | 1 |
Chen, JC; Hwang, JJ; Liao, MH; Lin, KJ; Pan, WH; Ting, G; Wey, SP; Yen, TC | 1 |
Gittings, D; Schenk, S | 1 |
Fleckenstein, AE; Hanson, GR; Rau, KS; Riddle, EL; Topham, MK | 1 |
Houlihan, WJ; Kelly, L | 1 |
France, CP; Frazer, A; Galici, R; Galli, A; Gould, GG; Jones, DJ; Lin, RZ; Sanchez, TA; Saunders, C | 1 |
Ishiwata, K; Kawamura, K; Oda, K | 1 |
Chen, N; Reith, ME; Rickey, J | 1 |
Cho, AK; Kuczenski, R; Melega, WP; O'Neil, ML; Segal, DS | 1 |
De Montis, MG; Grappi, S; Leggio, B; Masi, F; Nanni, G; Rauggi, R; Scheggi, S | 1 |
Gulley, JM; Hoover, BR; Larson, GA; Zahniser, NR | 1 |
Futatsubashi, M; Iyo, M; Minabe, Y; Mori, N; Nakamura, K; Okada, H; Ouchi, Y; Sekine, Y; Suzuki, K; Takei, N; Tsukada, H; Yoshikawa, E | 1 |
Helenius, H; Hublin, C; Någren, K; Partinen, M; Rinne, JO | 1 |
Chen, N; Cui, XN; Reith, ME; Wang, LC | 1 |
Appell, M; Berfield, JL; Chen, N; Dunn, WJ; Reith, ME; Wang, LC | 1 |
Buesing, WR; Norman, AB; Norman, MK; Tabet, MR; Tsibulsky, VL | 1 |
Agoston, GE; Katz, JL; Kopajtic, TA; Newman, AH | 1 |
Brake, WG; Diorio, J; Gratton, A; Meaney, MJ; Zhang, TY | 1 |
Chen, N; Reith, ME; Zhen, J | 2 |
Ordway, GA; Wee, S; Woolverton, WL | 1 |
Gulley, JM; Hanania, T; Larson, GA; Salaz, DO; Zahniser, NR | 1 |
Brownell, AL; McNaught, KS; Olanow, CW; Perl, DP | 1 |
Becker, KG; Cheadle, C; Donovan, DM; McCann, UD; Mechan, AO; Ricaurte, GA; Tong, L; Xie, T; Yuan, J | 1 |
Brownell, AL; Chen, YC; Isacson, O; Jenkins, BG; Sanchez-Pernaute, R | 1 |
Madras, BK; Meltzer, PC; Pham-Huu, DP | 1 |
Chen, N; Dutta, AK; Maiti, S; Reith, ME; Zhen, J | 1 |
Arias-Montaño, JA; Díaz-Romero, M; Eguibar, JR; Flores, G | 1 |
Mock, BH; Zheng, QH | 1 |
Andersen, ML; Hipólide, DC; Nobrega, JN; Papale, LA; Tufik, S | 1 |
Herndon, JG; Killiany, RJ; Luebke, JI; Moore, TL; Moss, MB; Rosene, DL; Schettler, SP | 1 |
Bondi, CD; Kozikowski, AP; Kulkarni, SS; Newman, AH; Pan, S; Surratt, CK; Ukairo, OT | 1 |
Fukumoto, D; Harada, N; Kakiuchi, T; Nishiyama, S; Tsukada, H | 1 |
Campbell, VC; Katz, JL; Kopajtic, TA; Newman, AH | 1 |
Furman, CA; Gnegy, ME; Guptaroy, B; Johnson, LA; Zhang, M | 1 |
Adams, RJ; Alexander, M; Chen, MK; Furukawa, E; Guilarte, TR; Lee, JS; McGlothan, JL; Wong, DF | 1 |
Aksenov, MY; Aksenova, MV; Booze, RM; Mactutus, CF; Nath, A; Ray, PD; Silvers, JM | 1 |
Dutta, AK; Reith, ME; Zhang, S; Zhen, J | 1 |
Bugert, P; Deuschle, M; Frankhauser, P; Grimmer, Y; Schloss, P; Schmidt, M | 1 |
Dar, DE; Metzger, TG; Uhl, GR; Vandenbergh, DJ | 1 |
Bottoncetti, A; Cini, N; Danieli, E; Guarna, A; Menchi, G; Pupi, A; Raspanti, S; Trabocchi, A | 1 |
Ben-Shahar, O; Ettenberg, A; Moscarello, JM | 1 |
Andren, PE; Svenningsson, P; Zhang, X | 1 |
Baroni, S; Betti, L; Cassano, GB; Catena, M; Dell'Osso, B; Fabbrini, L; Giannaccini, G; Italiani, P; Lucacchini, A; Marazziti, D | 1 |
Bendor, J; Bonab, AA; Elmaleh, DR; Fahey, MA; Fischman, AJ; Goodrich, C; Goulet, M; Lin, Z; Livni, E; Madras, BK; Meltzer, PC | 1 |
Cho, AK; Kuczenski, R; Lacan, G; Melega, WP; O'Neil, ML; Segal, DS | 1 |
Camarasa, J; Chipana, C; Escubedo, E; Pubill, D | 1 |
Kanno, T; Nakayama, T; Ouchi, Y; Shinke, T; Torizuka, T; Yoshikawa, E | 1 |
Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC; Pham-Huu, DP | 1 |
Hattori, N; Ida, H; Kono, S; Miyajima, H; Mizuno, Y; Ouchi, Y; Sakamoto, M; Shirakawa, K; Sugiura, T; Suzuki, H; Takahashi, Y; Tomiyama, H | 1 |
Daws, LC; Frazer, A; Giuffrida, A; Gould, GG; Owens, WA; Price, DA; Roberts, JL | 1 |
Di Monte, DA; Guillot, TS; Hatcher, JM; Jones, DP; McCormack, AL; Miller, GW; Pennell, KD; Richardson, JR | 1 |
Brownell, AL; Wang, JQ; Wang, X; Yu, M; Zhu, A | 1 |
Deutsch, HM; Kim, DI; Schweri, MM; Ye, X | 1 |
Bohnen, NI; Constantine, GM; Gedela, S; Kuwabara, H; Mathis, CA; Moore, RY; Studenski, SA | 1 |
Fei, J; Guo, LH; Li, S; Qin, GW; Zhao, G | 1 |
Brownell, AL; Cicchetti, F; Pellegrino, D; Saint-Pierre, M; Wang, X; Yu, M; Zhu, A | 1 |
Cepeda, IL; Cornfeldt, ML; Doudet, DJ; Flores, J; O'Kusky, JR | 1 |
Cho, AK; Fairbanks, LA; Jorgensen, MJ; Laćan, G; Melega, WP; Morton, G; Pham, J; Way, BM | 1 |
Bardo, MT; Bruntz, RC; Dwoskin, LP; Stairs, DJ; Zhu, J | 1 |
Bohnen, NI; Constantine, GM; Kuwabara, H; Mathis, CA; Moore, RY | 1 |
Lee, FJ; Liu, F; Moszczynska, A; Saleh, J; Vukusic, B; Zhang, H | 1 |
Cao, J; Desai, RI; Gerstbrein, K; Gether, U; Grundt, P; Katz, JL; Loland, CJ; Newman, AH; Sitte, HH; Zou, MF | 1 |
Adams, RJ; Alexander, M; Brasić, JR; Burton, NC; Chen, MK; Guilarte, TR; Kumar, A; Kuwabara, H; McGlothan, JL; Verina, T; Wong, DF; Zhou, Y | 1 |
Abbey, R; Alexander, M; Brasic, J; Dannals, RF; Kumar, A; Kuwabara, H; McCann, UD; Palermo, M; Ricaurte, GA; Wong, DF; Ye, W | 1 |
Baroni, S; Betti, L; Catena Dell'Osso, M; Dell'osso, B; Fabbrini, L; Giannaccini, G; Lucacchini, A; Marazziti, D; Masala, I | 1 |
Deng, C; du Bois, TM; Hsu, CW; Huang, XF; Li, Y; Tan, YY | 1 |
Fagerholm, V; Grönroos, T; Haaparanta, M; Koivula, T; Lipponen, T; Marjamäki, P; Perhola, O; Solin, O; Vepsäläinen, J | 1 |
Bergmann, ML; Beuming, T; Gether, U; Gracia, L; Javitch, JA; Kniazeff, J; Loland, CJ; Newman, AH; Raniszewska, K; Shi, L; Weinstein, H | 1 |
Aksenov, MY; Aksenova, MV; Booze, RM; Mactutus, CF; Silvers, JM | 1 |
Ambrosio, E; Crespo, JA; Del Olmo, N; García-Lecumberri, C; Higuera-Matas, A; Miguéns, M; Montoya, GL | 1 |
Beveridge, TJ; Nader, MA; Porrino, LJ; Smith, HR | 1 |
Chen, N; Dutta, AK; Kharkar, P; Mishra, M; Reith, ME; Schmitt, KC; Zhen, J | 1 |
Bohnen, NI; Constantine, GM; Gedela, S; Herath, P; Moore, RY | 1 |
Berger, ML; Pifl, C; Rebernik, P; Reither, H; Wolf, A | 1 |
Amable, R; Chen, J; Freed, WJ; Gabitzsch, E; Lee, CT; Lupica, CR; Spivak, CE; Vazin, T | 1 |
Ishibashi, K; Ishii, K; Ishiwata, K; Kawasaki, K; Mizusawa, H; Oda, K | 1 |
Kritzer, MF; Meyers, B | 1 |
Fei, X; Gitter, BD; Hutchins, GD; Mock, BH; Territo, PR; Winkle, WL; Yoder, KK; Zheng, QH | 1 |
Cassin, B; Little, KY; Ramssen, E; Roland, CJ; Volberg, V; Welchko, R | 1 |
Iida, A; Inoue, N; Kakiuchi, T; Kondo, Y; Muramatsu, S; Nakano, I; Nakayama, T; Okuno, T; Ono, F; Suzuki, Y; Takino, N; Terao, K; Tsukada, H | 1 |
Gai, Y; Guo, LH; Jiang, ZH; Qin, GW; Zhao, G; Zheng, XW | 1 |
Booze, RM; Mactutus, CF; Wallace, DR; Zhu, J | 1 |
Cha, JH; Eriksen, J; Gether, U; Newman, AH; Rasmussen, SG; Rasmussen, TN; Vaegter, CB; Zou, MF | 1 |
Ebbs, AL; Green, JL; Katz, JL; Newman, AH; Tallarida, RJ; Tanda, G; Tronci, V | 1 |
Farrer, MJ; Hattori, N; Imai, H; Inoue, Y; Ishii, K; Ishiwata, K; Kachergus, JM; Kitagawa, M; Kono, S; Mizoguchi, K; Mizuno, Y; Nishioka, K; Obi, T; Ross, OA; Takanashi, M | 1 |
Price, DA; Sorkin, A; Zahniser, NR | 1 |
Cui, XX; Guo, JF; Jiang, H; Lei, LF; Long, ZG; Pan, Q; Shen, L; Song, XW; Tang, BS; Wang, JL; Xia, K; Xiao, B; Yan, XX | 1 |
Jia, J; Li, B; Liu, L; Sun, Z; Tian, J; Wang, X; Wang, Y; Zhang, J | 1 |
Hiranita, T; Katz, JL; Soto, PL; Tanda, G | 1 |
Baroni, S; Betti, L; Catena Dell'osso, M; Consoli, G; Dell'Osso, B; Giannaccini, G; Lucacchini, A; Marazziti, D; Masala, I | 1 |
Hayashi, T; Saiki, H; Takahashi, J; Takahashi, R | 1 |
Futatsubashi, M; Ouchi, Y; Torizuka, T; Yagi, S; Yokokura, M; Yoshihara, Y; Yoshikawa, E | 1 |
Donovan, DM; Katz, JL; Kopajtic, TA; Liu, Y; Newman, AH; Surratt, CK | 1 |
Abad, S; Camarasa, J; Escubedo, E; Pubill, D; Torres, I | 1 |
Desai, A; Fraser, R; Gnegy, ME; Guptaroy, B; Zhang, M | 1 |
Bardo, MT; Booze, RM; Dwoskin, LP; Gomez, AM; Mactutus, CF; Midde, NM; Wooters, TE; Zhu, J | 1 |
Cao, L; Guo, QY; Wang, XM; Wang, XY; Zhang, YF | 1 |
Albrecht, D; Anand, A; Barkay, G; Dzemidzic, M; Hutchins, GD; Karne, H; Normandin, MD; Yoder, KK; Zheng, QH | 1 |
Cao, J; Hiranita, T; Katz, JL; Kohut, SJ; Kopajtic, T; Newman, AH; Soto, PL; Tanda, G | 1 |
Ali, S; Dutta, AK; Reith, ME; Zhen, J | 1 |
Alstrup, AK; Doudet, DJ; Gjedde, A; Høltzermann, M; Jakobsen, S; Landau, AM; Møller, A; Nahimi, A; Simonsen, M; Vang, K; Wegener, G | 1 |
Madras, BK; Meltzer, PC; Torun, L | 1 |
Huang, T; Liang, X; Shi, X; Tang, G; Wang, H; Zhang, X | 1 |
Fujimoto, M; Konishi, T; Kono, S; Matsushita, K; Miyajima, H; Ouchi, Y; Terada, T | 1 |
Akamine, S; Asakawa, T; Mizuma, H; Namba, H; Onoe, H; Shukuri, M; Sugiyama, K; Tsukada, H; Yokoyama, C | 1 |
Deng, H; Huang, T; Liang, X; Tang, G; Wang, H; Yi, C; Zhang, X | 1 |
Liu, S; Shen, L; Tian, ZM; Wang, RM; Wieman, J; Yan, Y; Yin, F; Zhao, QJ | 1 |
Agarwal, P; Dinelle, K; Hayflick, S; Heffernan, N; Hogarth, P; Kuriakose, R; MacLeod, P; McKenzie, J; Sossi, V; Stoessl, AJ | 1 |
Brown, CA; Flores, HP; Karimi, M; Loftin, SK; Moerlein, SM; Perlmutter, JS; Tian, L; Videen, TO | 1 |
Rao, A; Sorkin, A; Zahniser, NR | 1 |
Domino, EF; Harada, N; Kakiuchi, T; Nishiyama, S; Ohba, H; Tsukada, H; Yamamoto, S | 1 |
Andersson, PL; Fonnum, F; Stenberg, M; Walaas, SI; Wigestrand, MB | 1 |
Gong, X; Liang, X; Liu, L; Wang, X; Zhang, W | 1 |
Chen, HX; Gao, N; Jin, ZL; Li, XR; Li, YF; Tang, Y; Xiong, J; Zhang, JR | 1 |
Brown, CA; Karimi, M; Loftin, SK; Perlmutter, JS; Tian, L | 1 |
Ali, S; Antonio, T; Cheng, SY; Jones, KT; Reith, ME; Zhen, J | 1 |
Huang, X; Midde, NM; Quizon, PM; Sun, WL; Yuan, Y; Zhan, CG; Zhu, J | 1 |
Ananthan, S; Baumann, MH; Moukha-Chafiq, O; Partilla, JS; Pathak, V; Rothman, RB; Saini, SK | 1 |
Gomez, AM; Midde, NM; Quizon, PM; Sun, WL; Yuan, Y; Zhan, CG; Zhu, J | 1 |
Ding, ZT; Ge, JJ; Huang, SF; Liu, SY; Wang, J; Wang, YX; Wu, JJ; Wu, P; Zhao, J; Zuo, CT | 1 |
Chen, T; Chen, Y; Guo, Z; Wang, R; Xu, B; Zhang, J; Zhu, H | 1 |
Ananth, M; Hadjiargyrou, M; Komatsu, DE; Robison, LS; Thanos, PK | 1 |
Gross, JD; Kaski, SW; Schroer, AB; Setola, V; Siderovski, DP; Wix, KA | 1 |
Chen, T; Fu, LP; Gao, ZB; Wang, W; Wang, ZF; Xu, BX; Zhao, XL | 1 |
Gnegy, ME; Guptaroy, B; Jones, KT; Mikelman, SR; Reith, MEA; Schmitt, KC; Zhen, J | 1 |
Chen, Y; Lian, Y; Wang, C; Wang, R; Zhang, Y | 1 |
Li, X; Li, Y; Mutaerbieke, N; Qin, Y; Yibulayin, A; Zhang, Q; Zhao, X | 1 |
Baird, TR; Carroll, FI; Eltit, JM; Karin, KN; Marsh, SA; Medina-Contreras, JML; Negus, SS | 1 |
1 review(s) available for cocaine and (3h)2-carbomethoxy-3-(4-fluorophenyl)tropane
Article | Year |
---|---|
Positron emission tomography of cocaine binding sites on the dopamine transporter.
Topics: Animals; Binding Sites; Brain; Cocaine; Dopamine; Tissue Distribution; Tomography, Emission-Computed | 1994 |
5 trial(s) available for cocaine and (3h)2-carbomethoxy-3-(4-fluorophenyl)tropane
Article | Year |
---|---|
Reproducibility and effect of levodopa on dopamine transporter function measurements: a [18F]CFT PET study.
Topics: Adult; Aged; Antiparkinson Agents; Biological Transport; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Reproducibility of Results; Tomography, Emission-Computed | 2000 |
Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease.
Topics: Aged; Arteries; Blood Pressure; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Frontal Lobe; Gait; Gyrus Cinguli; Heart Rate; Humans; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Putamen; Substantia Nigra; Tomography, Emission-Computed; Walking | 2001 |
The influence of residual nor-β-CFT in 11C CFT injection on the Parkinson disease diagnosis: a 11C CFT PET study.
Topics: Carbon Radioisotopes; Cocaine; Drug Residues; Female; Fluorodeoxyglucose F18; Humans; Injections, Intravenous; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography | 2012 |
Human radiation dose estimation of (11)C-CFT using whole-body PET.
Topics: Cocaine; Female; Humans; Injections, Intravenous; Male; Middle Aged; Positron-Emission Tomography; Radiation Dosage; Radiometry; Whole Body Imaging | 2012 |
Transplantation of human retinal pigment epithelium cells in the treatment for Parkinson disease.
Topics: Aged; Aged, 80 and over; Antigens, CD; Bucladesine; Carbon Isotopes; Cell Differentiation; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; Female; Fetus; Flow Cytometry; Growth Substances; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neural Stem Cells; Neurons; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Positron-Emission Tomography; Retinal Pigment Epithelium; Severity of Illness Index; Time Factors; Treatment Outcome; Tretinoin | 2012 |
384 other study(ies) available for cocaine and (3h)2-carbomethoxy-3-(4-fluorophenyl)tropane
Article | Year |
---|---|
Conditioned taste aversion and operant behaviour in rats: effects of cocaine and a cocaine analogue (WIN 35,428).
Topics: Animals; Avoidance Learning; Cocaine; Conditioning, Operant; Rats | 1979 |
Striatal quinolinic acid lesions increase [3H]WIN 35,428 binding to the dopamine transporter.
Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Huntington Disease; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 1992 |
Cocaine binding sites in mouse striatum, dopamine autoreceptors, and cocaine-induced locomotion.
Topics: Aging; Animals; Apomorphine; Cocaine; Corpus Striatum; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Receptors, Dopamine; Receptors, Opioid | 1992 |
Dopamine transport: pharmacological distinction between the synaptic membrane and the vesicular transporter in rat striatum.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Synaptic Membranes; Synaptic Vesicles; Tetrabenazine | 1992 |
5-HT3 receptor antagonists block cocaine-induced locomotion via a PCPA-sensitive mechanism.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dose-Response Relationship, Drug; Fenclonine; Indoles; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Tropanes; Tropisetron | 1992 |
Distribution of cocaine recognition sites in monkey brain: II. Ex vivo autoradiography with [3H]CFT and [125I]RTI-55.
Topics: Animals; Autoradiography; Binding Sites; Brain; Caudate Nucleus; Cocaine; Iodine Radioisotopes; Putamen; Saimiri; Tissue Distribution; Tritium | 1992 |
Determination of radioligand specific activity using competition binding assays.
Topics: Animals; Binding, Competitive; Cocaine; Corpus Striatum; Female; Kinetics; Ligands; Male; Mice; Mice, Inbred C57BL; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tritium | 1992 |
Changes of drug biodistribution in the methamphetamine sensitized rat brain.
Topics: Amphetamines; Animals; Brain; Cocaine; Iofetamine; Male; Methamphetamine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tissue Distribution | 1992 |
Expression of a single dopamine transporter cDNA can confer two cocaine binding sites.
Topics: Animals; Binding Sites; Carrier Proteins; Cell Line; Cloning, Molecular; Cocaine; Corpus Striatum; DNA; Dopamine Plasma Membrane Transport Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Nerve Tissue Proteins; Radioligand Assay; Rats; Receptors, Drug | 1992 |
Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cocaine; Disease Models, Animal; Dopamine; Immunohistochemistry; Macaca fascicularis; Motor Activity; Nerve Fibers; Parkinson Disease, Secondary; Radioligand Assay; Tomography, Emission-Computed | 1992 |
Microheterogeneity of dopamine transporters in rat striatum and nucleus accumbens.
Topics: Animals; Azides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Electrophoresis, Polyacrylamide Gel; Glycoside Hydrolases; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Nerve Tissue Proteins; Neuraminidase; Nucleus Accumbens; Piperazines; Rats; Rats, Inbred Strains | 1992 |
Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins | 1992 |
The low affinity binding site for the cocaine analog, WIN 35,428 is an artifact of freezing caudate tissue.
Topics: Animals; Artifacts; Binding Sites; Caudate Nucleus; Cocaine; Cryopreservation; Kinetics; Male; Rabbits; Rats; Rats, Inbred Strains | 1992 |
Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Probes; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Receptors, Drug | 1992 |
Radiolabeling of dopamine uptake sites in mouse striatum: comparison of binding sites for cocaine, mazindol, and GBR 12935.
Topics: Animals; Binding Sites; Buffers; Cocaine; Corpus Striatum; Dopamine; Drug Interactions; Ethylmaleimide; Kinetics; Male; Mazindol; Membranes; Mice; Mice, Inbred BALB C; Phosphates; Piperazines; Radioligand Assay; Temperature; Tritium; Tromethamine | 1992 |
Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes.
Topics: Animals; Benzazepines; Cocaine; Discrimination Learning; Dopamine Agents; Dopamine Antagonists; Levodopa; Male; Oxazines; Receptors, Dopamine; Saimiri; Time Factors | 1991 |
Self-administration of the high-affinity cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
Topics: Animals; Carrier Proteins; Cocaine; Receptors, Drug; Reinforcement Schedule; Saimiri; Self Administration | 1991 |
Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT.
Topics: Animals; Autoradiography; Binding Sites; Brain; Carrier Proteins; Cocaine; Female; Male; Receptors, Drug; Saimiri; Tissue Distribution; Tritium | 1991 |
A rapid binding assay for solubilized dopamine transporters using [3H]WIN 35,428.
Topics: Adsorption; Animals; Binding, Competitive; Brain Chemistry; Carrier Proteins; Caudate Nucleus; Centrifugation; Charcoal; Cocaine; Dogs; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Indicators and Reagents; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Stereoisomerism | 1991 |
Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum.
Topics: Aged; Autoradiography; Carrier Proteins; Caudate Nucleus; Cocaine; Corpus Striatum; Humans; Parkinson Disease; Putamen; Receptors, Drug; Reference Values; Tritium | 1991 |
Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909.
Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Injections, Intravenous; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Piperazines; Radioimmunoassay; Receptors, Drug | 1991 |
Binding of the cocaine analog 2 beta-[3H] carboxymethoxy-3 beta-(4-fluorophenyl)tropane to the serotonin transporter.
Topics: Biological Transport; Blood Proteins; Carrier Proteins; Chlorides; Cocaine; Humans; Hydrogen-Ion Concentration; Imipramine; Potassium; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sodium | 1991 |
Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Line; Cell Membrane; Cloning, Molecular; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Models, Structural; Molecular Sequence Data; Nerve Tissue Proteins; Oligodeoxyribonucleotides; Oocytes; Plasmids; Polymerase Chain Reaction; Protein Conformation; Rats; RNA, Messenger; Transcription, Genetic; Transfection; Xenopus | 1991 |
Synthesis and ligand binding of cocaine isomers at the cocaine receptor.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cell Membrane; Chemical Phenomena; Chemistry; Cocaine; Corpus Striatum; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Drug; Stereoisomerism | 1991 |
Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor.
Topics: Animals; Binding Sites; Carrier Proteins; Chemical Phenomena; Chemistry; Cocaine; Female; Macaca fascicularis; Male; Receptors, Drug; Structure-Activity Relationship; Tritium; Tropanes | 1991 |
In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cerebellum; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Radioligand Assay; Receptors, Drug; Tissue Distribution | 1991 |
New, potent cocaine analogs: ligand binding and transport studies in rat striatum.
Topics: Animals; Binding, Competitive; Biological Transport; Cocaine; Corpus Striatum; Dopamine; In Vitro Techniques; Radioligand Assay; Rats; Synaptosomes | 1990 |
Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Caudate Nucleus; Cocaine; In Vitro Techniques; Male; Putamen; Receptors, Drug; Saimiri | 1990 |
N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Discrimination, Psychological; Female; Macaca fascicularis; Male; Nortropanes; Receptors, Drug | 1990 |
Attenuation by dopamine uptake blockers of the inhibitory effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and some of its analogs on NADH-linked metabolism in mouse neostriatal slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cocaine; Corpus Striatum; Dopamine; In Vitro Techniques; Lactates; Lactic Acid; Male; Mice; NAD; Neurotransmitter Uptake Inhibitors; Rats; Tyrosine 3-Monooxygenase | 1989 |
Cocaine receptors: in vivo labeling with 3H-(-)cocaine, 3H-WIN 35,065-2, and 3H-WIN 35,428.
Topics: Animals; Carrier Proteins; Cocaine; Male; Mice; Receptors, Drug | 1989 |
Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; In Vitro Techniques; Kinetics; Macaca fascicularis; Putamen; Receptors, Drug | 1989 |
Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Flunarizine; Male; Mice; Nalidixic Acid; Naphthyridines; Piperazines; Pyridines; Pyridinium Compounds; Pyrroles; Rats; Rats, Inbred Strains; Substantia Nigra | 1986 |
Saturable (3H)cocaine binding in central nervous system of mouse.
Topics: Animals; Brain; Cell Membrane; Cocaine; Male; Mice; Morphine; Naloxone; Neurotransmitter Agents; Nicotine; Tubocurarine | 1980 |
Cocaine cue in pigeons: time course studies and generalization to structurally related compounds (norcocaine, WIN 35,428 and 35,065-2) and (+)-amphetamine.
Topics: Animals; Cocaine; Columbidae; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Structure-Activity Relationship; Time Factors | 1981 |
Conditioned taste aversion and operant behavior in rats: effects of cocaine, apomorphine and some long-acting derivatives.
Topics: Animals; Apomorphine; Avoidance Learning; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Rats; Taste; Time Factors | 1981 |
Rate of binding of various inhibitors at the dopamine transporter in vivo.
Topics: Animals; Binding, Competitive; Bupropion; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Time Factors | 1995 |
Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tropanes | 1995 |
Binding of d-threo-[11C]methylphenidate to the dopamine transporter in vivo: insensitivity to synaptic dopamine.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Presynaptic Terminals; Rats; Time Factors | 1995 |
Characterization of a recombinant human dopamine transporter in multiple cell lines.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Recombinant Proteins; Tritium; Tumor Cells, Cultured | 1995 |
Effects of cocaine and the cocaine analog CFT on glutamatergic neurons.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; Male; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Ion channel inhibitors may function as potential modulators of cocaine binding.
Topics: Animals; Brain; Calcium Channel Agonists; Calcium Channel Blockers; Cocaine; Corpus Striatum; In Vitro Techniques; Ion Channels; Male; Potassium Channels; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sodium Channels | 1993 |
Amygdala dopamine levels are markedly elevated after self- but not passive-administration of cocaine.
Topics: Amygdala; Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Self Stimulation; Serotonin | 1994 |
[3H]WIN 35,428 binding in the caudate nucleus of the rabbit: evidence for a single site on the dopamine transporter.
Topics: Animals; Binding Sites; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rabbits | 1995 |
Selective labeling of the dopamine transporter by the high affinity ligand 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley | 1995 |
Locomotor stimulant effects of cocaine and novel cocaine analogs in DBA/2J and C57BL/6J inbred mice.
Topics: Animals; Cocaine; Dopamine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Norepinephrine; Serotonin; Species Specificity; Stereotyped Behavior; Stimulation, Chemical | 1995 |
[3H]WIN 35,428 ([3H]CFT) binds to multiple charge-states of the solubilized dopamine transporter in primate striatum.
Topics: Animals; Carrier Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electrochemistry; Female; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Saimiri; Tritium | 1995 |
Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Computer Simulation; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
Spermine interacts with cocaine binding sites on dopamine transporters.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Inbred F344; Receptors, Drug; Serotonin; Serotonin Plasma Membrane Transport Proteins; Spermine | 1994 |
Binding of bromine-substituted analogs of methylphenidate to monoamine transporters.
Topics: Animals; Binding, Competitive; Bromine; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Microdialysis; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Tomography, Emission-Computed, Single-Photon | 1994 |
Translocation of dopamine and binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations. Inhibition by various blockers.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Synaptosomes; Tritium | 1995 |
Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression.
Topics: Animals; Carrier Proteins; Cell Membrane; Chlorocebus aethiops; Cocaine; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Recombinant Proteins; Structure-Activity Relationship | 1995 |
Inhalation anaesthetic competition at high-affinity cocaine binding sites in rat brain synaptosomes.
Topics: Anesthesia, Inhalation; Animals; Binding Sites; Binding, Competitive; Brain; Cocaine; Dose-Response Relationship, Drug; Halothane; Isoflurane; Male; Rats; Rats, Sprague-Dawley; Synaptosomes | 1994 |
Dopamine terminal loss and onset of motor symptoms in MPTP-treated monkeys: a positron emission tomography study with 11C-CFT.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Carbon Radioisotopes; Caudate Nucleus; Cocaine; Dopamine; Motor Activity; Nerve Endings; Parkinson Disease, Secondary; Putamen; Tomography, Emission-Computed | 1994 |
Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Guanethidine; Male; Mice; Microdialysis; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Neurons; Premedication; Rats; Rats, Sprague-Dawley; Species Specificity; Synaptosomes | 1994 |
Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Dose-Response Relationship, Drug; Guanethidine; Male; Mice; Monoamine Oxidase; MPTP Poisoning; Neostriatum; Premedication; Rats; Rats, Sprague-Dawley; Species Specificity | 1994 |
Phorbol esters alter functions of the expressed dopamine transporter.
Topics: Animals; Carrier Proteins; Cells, Cultured; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Kinase C; Rats; Sodium; Tetradecanoylphorbol Acetate | 1994 |
High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims.
Topics: Adult; Binding Sites; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Overdose; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins | 1994 |
Can stimulant binding and dopamine transport be differentiated? Studies with GBR 12783 derivatives.
Topics: Animals; Cocaine; Dopamine; Piperazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.
Topics: Animals; Carrier Proteins; Caudate Nucleus; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Protein Binding; Putamen; Serotonin; Serotonin Plasma Membrane Transport Proteins | 1994 |
Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Chemical; Models, Molecular; Molecular Conformation; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
Characterization of [125I]RTI-55 binding to dog caudate dopamine transporter.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cell Membrane; Cholic Acids; Citalopram; Cocaine; Desipramine; Dogs; Dopamine Plasma Membrane Transport Proteins; Filtration; Iodine Radioisotopes; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Solubility | 1993 |
11C-WIN 35,428 for detecting dopamine depletion in mild Parkinson's disease.
Topics: Carbon Radioisotopes; Cocaine; Dopamine; Humans; Parkinson Disease; Tomography, Emission-Computed | 1994 |
Clinical and preclinical PET correlates of parkinsonism with 11C-WIN 35,428.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carbon Radioisotopes; Cocaine; Humans; Parkinson Disease; Parkinson Disease, Secondary; Tomography, Emission-Computed | 1994 |
Intravenously administered dopamine transporter site radioligand is not significantly retained in mouse substantia nigra or other sites outside of basal ganglia.
Topics: Animals; Basal Ganglia; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Injections, Intravenous; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Radioligand Assay; Substantia Nigra | 1994 |
Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration.
Topics: Animals; Biogenic Monoamines; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Wistar; Reference Values; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tissue Distribution; Tritium | 1994 |
[3H]WIN 35,428 binding to the dopamine uptake carrier. I. Effect of tonicity and buffer composition.
Topics: Animals; Buffers; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Hypotonic Solutions; Isotonic Solutions; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phosphates; Rats; Rats, Sprague-Dawley; Sodium; Sucrose; Tritium | 1994 |
[3H]WIN 35,428 binding to the dopamine uptake carrier. II. Effect of membrane fractionation procedure and freezing.
Topics: Animals; Carrier Proteins; Chemical Fractionation; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Freezing; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Nerve Tissue Proteins; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Tritium | 1994 |
Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice.
Topics: Animals; Benzamides; Benzazepines; Binding Sites; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nerve Tissue Proteins; Paroxetine; Pharmacogenetics; Pyrrolidines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Serotonin Plasma Membrane Transport Proteins; Species Specificity; Sulpiride | 1993 |
Analysis of cocaine receptor site ligand binding by three-dimensional Voronoi site modeling approach.
Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Chemical Phenomena; Chemistry, Physical; Cocaine; Corpus Striatum; Models, Molecular; Rats; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship; Thermodynamics | 1993 |
In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [11C]WIN 35,428.
Topics: Adult; Affect; Aged; Aged, 80 and over; Animals; Blood Pressure; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Electrocardiography; Female; Humans; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Endings; Nerve Tissue Proteins; Papio; Pulse; Receptors, Dopamine; Tomography, Emission-Computed | 1993 |
Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.
Topics: Affinity Labels; Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, sigma | 1993 |
Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cells, Cultured; Cloning, Molecular; Cocaine; DNA; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Piperazines | 1994 |
Cocaine use increases [3H]WIN 35428 binding sites in human striatum.
Topics: Adult; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Tritium | 1993 |
[3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey.
Topics: Aging; Animals; Brain; Cocaine; Corpus Striatum; Injections, Intravenous; Saimiri; Time Factors; Tissue Distribution; Tritium | 1993 |
Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease.
Topics: Biomarkers; Brain; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Cerebellum; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Middle Aged; Nerve Tissue Proteins; Organ Specificity; Parkinson Disease; Putamen; Tomography, Emission-Computed | 1993 |
Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.
Topics: Animals; Biogenic Amines; Biological Transport; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Comparison of [3H]WIN 35,428 binding, a marker for dopamine transporter, in embryonic mesencephalic neuronal cultures with striatal membranes of adult rats.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cell Membrane; Cells, Cultured; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Embryo, Mammalian; Female; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Zinc modulation of drug binding, cocaine affinity states, and dopamine uptake on the dopamine uptake complex.
Topics: Animals; Binding, Competitive; Buffers; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ethylmaleimide; In Vitro Techniques; Male; Membrane Proteins; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Zinc | 1993 |
The cocaine analog WIN 35,428 binds to two sites in fresh rat caudate-putamen: significance of assay procedures.
Topics: Animals; Binding Sites; Caudate Nucleus; Cocaine; In Vitro Techniques; Male; Putamen; Radioligand Assay; Rats; Rats, Sprague-Dawley | 1993 |
Cationic and anionic requirements for the binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)[3H]tropane to the dopamine uptake carrier.
Topics: Animals; Anions; Carrier Proteins; Cations; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phosphates; Potassium; Rats; Sodium; Tritium | 1993 |
Multiple drug classes and hyperosmolarity alter binding of muscarinic drugs to mesothelial cells in vitro.
Topics: Animals; Atropine; Cells, Cultured; Cocaine; Cycloheximide; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Epithelium; Mannitol; Muscarinic Antagonists; N-Methylscopolamine; Osmolar Concentration; Parasympatholytics; Peritoneum; Piperazines; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Sodium Chloride | 1995 |
Localization and quantification of the dopamine transporter: comparison of [3H]WIN 35,428 and [125I]RTI-55.
Topics: Animals; Autoradiography; Brain Chemistry; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Behavioral sensitization, behavioral tolerance, and increased [3H]WIN 35,428 binding in rabbit caudate nucleus after repeated injections of cocaine.
Topics: Animals; Behavior, Animal; Binding Sites; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Tolerance; Female; Injections, Intravenous; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Motor Activity; Narcotics; Nerve Tissue Proteins; Rabbits; Seizures; Up-Regulation | 1995 |
Conformational analysis of methylphenidate and its structural relationship to other dopamine reuptake blockers such as CFT.
Topics: Cocaine; Crystallography, X-Ray; Dopamine Uptake Inhibitors; Methylphenidate; Molecular Structure; Stereoisomerism | 1995 |
PET examination of the monoamine transporter with [11C]beta-CIT and [11C]beta-CFT in early Parkinson's disease.
Topics: Adult; Biological Transport; Brain; Carbon Radioisotopes; Cocaine; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Parkinson Disease; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins | 1995 |
Effects of WIN 35,428 a potent antagonist of dopamine transporter on sleep and locomotor activity in rats.
Topics: Analysis of Variance; Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Rats; Rats, Wistar; Sleep | 1995 |
[3H]WIN 35,428 [2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane] binding to rat brain membranes. Comparing dopamine cell body areas with nerve terminal regions.
Topics: Animals; Brain; Cell Membrane; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Mesencephalon; Nerve Endings; Nucleus Accumbens; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium | 1996 |
The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Self Administration; Tetrabenazine | 1996 |
Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs.
Topics: Animals; Cocaine; Dopamine; Male; Methylphenidate; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1996 |
Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Carrier Proteins; Cerebellum; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kinetics; Lesch-Nyhan Syndrome; Magnetic Resonance Imaging; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Organ Specificity; Putamen; Reference Values; Rett Syndrome; Time Factors; Tomography, Emission-Computed | 1996 |
Synthesis and ligand binding of eta(6)-(2beta-carbomethoxy-3beta-phenyltropane) transition metal complexes.
Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Organometallic Compounds; Putamen; Rats; Structure-Activity Relationship; Tropanes | 1996 |
The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain.
Topics: Animals; Base Sequence; Binding Sites; Biological Transport; Carrier Proteins; Cells, Cultured; Chlorocebus aethiops; Cocaine; DNA Primers; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Recombinant Fusion Proteins; Sequence Deletion; Structure-Activity Relationship | 1996 |
Effect of dopaminergic drugs on the in vivo binding of [3H]WIN 35,428 to central dopamine transporters.
Topics: Amphetamine; Animals; Carrier Proteins; Cerebellum; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Nerve Tissue Proteins | 1996 |
Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?
Topics: Animals; Benzocaine; Binding, Competitive; Carrier Proteins; Cations; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Hydrogen-Ion Concentration; Kinetics; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Synaptosomes | 1996 |
[3H]WIN 35,428 binding in the human brain.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Frontal Lobe; Humans; Male; Middle Aged; Paroxetine; Radioligand Assay; Selective Serotonin Reuptake Inhibitors | 1996 |
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine; Nortropanes; Paroxetine; Radioligand Assay; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Structure-Activity Relationship; Tropanes | 1996 |
The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter.
Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Meperidine; Models, Molecular; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Saimiri | 1996 |
[18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: biodistribution in rats.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluorine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed | 1996 |
Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride].
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Tropanes | 1996 |
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Serotonin; Stereoisomerism; Structure-Activity Relationship | 1996 |
Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121.
Topics: Adult; Autoradiography; Binding Sites; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Tissue Distribution | 1995 |
Highly potent cocaine analogs cause long-lasting increases in locomotor activity.
Topics: Analysis of Variance; Animals; Behavior, Animal; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Motor Activity; Rats; Rats, Sprague-Dawley | 1996 |
The effects of phosphorylation on the functional regulation of an expressed recombinant human dopamine transporter.
Topics: Animals; Blotting, Western; Carrier Proteins; Cocaine; COS Cells; DNA, Complementary; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Glycosylation; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phosphorus Radioisotopes; Phosphorylation; Recombinant Proteins; Transfection; Tritium | 1996 |
Quantification of dopamine transporter density in monkeys by dynamic PET imaging of multiple injections of 11C-CFT.
Topics: Animals; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Cerebellum; Cocaine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Image Processing, Computer-Assisted; Isotope Labeling; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Neurological; Motor Skills; MPTP Poisoning; Neostriatum; Nerve Tissue Proteins; Receptors, Dopamine; Tomography, Emission-Computed | 1996 |
Enhanced amphetamine sensitivity and increased expression of dopamine D2 receptors in postpubertal rats after neonatal excitotoxic lesions of the medial prefrontal cortex.
Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Benzamides; Benzazepines; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; In Situ Hybridization; Locomotion; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotoxins; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sensitivity and Specificity; Sexual Maturation; Tetrahydronaphthalenes; Tritium | 1996 |
Binding domains for blockers and substrates on the cloned human dopamine transporter studied by protection against N-ethylmaleimide-induced reduction of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)[3H]tropane ([3H]WIN 35,428) binding.
Topics: Animals; Binding Sites; Carrier Proteins; Cell Membrane; Cloning, Molecular; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ethylmaleimide; Humans; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Transfection; Tumor Cells, Cultured | 1996 |
The stimulatory and inhibitory components of cocaine's actions on the 5-HTP-induced 5-HT2A receptor response.
Topics: 1-Naphthylamine; 5-Hydroxytryptophan; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Head Movements; Male; Mice; Mice, Inbred ICR; Norepinephrine; Piperazines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline | 1996 |
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.
Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats | 1996 |
In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats.
Topics: Animals; Antisense Elements (Genetics); Behavior, Animal; Carrier Proteins; Central Nervous System; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Hormone Antagonists; Membrane Glycoproteins; Membrane Transport Proteins; Mifepristone; Narcotics; Nerve Tissue Proteins; Neurons; Ovariectomy; Posture; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, Progesterone; Sexual Behavior, Animal; Steroids; Ventromedial Hypothalamic Nucleus | 1996 |
Cocaine congeners as PET imaging probes for dopamine terminals.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Carbon Radioisotopes; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Female; Macaca fascicularis; Male; Nerve Endings; Parkinson Disease, Secondary; Tomography, Emission-Computed | 1996 |
Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites.
Topics: Animals; Autoradiography; Brain; Carrier Proteins; Citalopram; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Iodine Radioisotopes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Parkinson Disease; Saimiri; Selective Serotonin Reuptake Inhibitors; Tomography, Emission-Computed, Single-Photon | 1996 |
Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway.
Topics: Animals; Arachidonic Acid; Brain Neoplasms; Carrier Proteins; Cattle; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Glioma; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins | 1996 |
Effects of drugs on food- and cocaine-maintained responding, III: Dopaminergic antagonists.
Topics: Animals; Benzazepines; Chlorpromazine; Cocaine; Conditioning, Operant; Dopamine Antagonists; Dopamine Uptake Inhibitors; Food; Macaca mulatta; Male; Narcotics; Pimozide; Self Administration | 1996 |
Comparison of [11C]methyl triflate and [11C]methyl iodide in the synthesis of PET radioligands such as [11C]beta-CIT and [11C]beta-CFT.
Topics: Carbon Isotopes; Cocaine; Dopamine Uptake Inhibitors; Hydrocarbons, Iodinated; Indicators and Reagents; Isotope Labeling; Mesylates; Methylation; Radioactive Tracers; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1995 |
Binding domains for blockers and substrates on the dopamine transporter in rat striatal membranes studied by protection against N-ethylmaleimide-induced reduction of [3H]WIN 35,428 binding.
Topics: Amphetamine; Animals; Binding Sites; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ethylmaleimide; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Conformation; Rats; Rats, Sprague-Dawley; Sodium; Tritium | 1997 |
Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.
Topics: Animals; Carrier Proteins; Citalopram; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats | 1997 |
Comparative evaluation of [3H]WIN 35428 and [3H]GBR 12935 as markers of dopamine innervation density in brain.
Topics: Animals; Autoradiography; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Piperazines; Rats; Rats, Sprague-Dawley | 1997 |
3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.
Topics: Animals; Benztropine; Binding, Competitive; Carrier Proteins; Cocaine; Discrimination, Psychological; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Motor Activity; Neostriatum; Nerve Tissue Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Tropanes | 1997 |
Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Motor Activity; Nerve Tissue Proteins; Rats; Tropanes | 1997 |
Striatal dopamine nerve terminal markers but not nigral cellularity are reduced in spinocerebellar ataxia type 1.
Topics: Adult; Biomarkers; Cadaver; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Endings; Nerve Tissue Proteins; Putamen; Spinocerebellar Degenerations; Substantia Nigra; Tetrabenazine | 1997 |
Regulation of the functional activity of the human dopamine transporter by protein kinase C.
Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Okadaic Acid; Phosphoric Monoester Hydrolases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1997 |
Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter.
Topics: Animals; Binding Sites; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Esters; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Chemical; Models, Molecular; Nerve Tissue Proteins; Piperidines; Rats; Rats, Sprague-Dawley; Tropanes | 1997 |
WIN 35,428 and mazindol are mutually exclusive in binding to the cloned human dopamine transporter.
Topics: Binding, Competitive; Carrier Proteins; Cloning, Molecular; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Chemical; Nerve Tissue Proteins; Radioligand Assay; Recombinant Proteins; Tritium; Tumor Cells, Cultured | 1997 |
Cations affect [3H]mazindol and [3H]WIN 35,428 binding to the human dopamine transporter in a similar fashion.
Topics: Animals; Carrier Proteins; Cations, Divalent; Cations, Monovalent; Cell Membrane; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Glioma; Humans; Kinetics; Lithium; Magnesium; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mercury; Nerve Tissue Proteins; Potassium; Protein Binding; Rats; Sodium; Tritium; Tumor Cells, Cultured; Zinc | 1997 |
Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Parkinson Disease; Primates; Radioligand Assay; Radiopharmaceuticals; Reference Values; Substance-Related Disorders; Tomography, Emission-Computed | 1998 |
Dopamine transporter changes in neuropsychiatric disorders.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Child; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Iodine Radioisotopes; Lesch-Nyhan Syndrome; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Reference Values; Rett Syndrome; Substance-Related Disorders; Tomography, Emission-Computed; Tourette Syndrome | 1998 |
Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists.
Topics: Animals; Binding, Competitive; Carrier Proteins; CHO Cells; Cocaine; Cricetinae; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Structure-Activity Relationship | 1997 |
In vivo saturation kinetics of two dopamine transporter probes measured using a small animal positron emission tomography scanner.
Topics: Animals; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Tomography, Emission-Computed | 1997 |
Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Brain; Cocaine; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Magnetic Resonance Imaging; Microdialysis; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Sensitivity and Specificity; Tomography, Emission-Computed | 1997 |
Chronic administration of the selective dopamine uptake inhibitor GBR 12,909, but not cocaine, produces marked decreases in dopamine transporter density.
Topics: Animals; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Piperazines; Rats; Rats, Sprague-Dawley | 1997 |
Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Neostriatum; Nerve Tissue Proteins; Neurotoxins; Papio; Substance-Related Disorders; Tomography, Emission-Computed; Tritium | 1998 |
Parametric imaging of ligand-receptor binding in PET using a simplified reference region model.
Topics: Animals; Benzazepines; Brain; Brain Mapping; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Image Processing, Computer-Assisted; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Tomography, Emission-Computed | 1997 |
2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Symporters | 1997 |
gamma-Aminobutyric acidA agonists differentially augment gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice.
Topics: Animals; Behavior, Animal; Benzazepines; Cocaine; Dopamine Agonists; GABA-A Receptor Agonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscimol; Piperazines | 1998 |
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Crystallography, X-Ray; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Models, Molecular; Molecular Structure; Motor Activity; Nerve Tissue Proteins; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Tropanes | 1997 |
Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbazoles; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Guinea Pigs; Isothiocyanates; Ligands; Liver; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Rats; Receptors, sigma | 1997 |
Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Rats; Tropanes | 1997 |
Striatal uptake of the dopamine reuptake ligand [11C]beta-CFT is reduced in Alzheimer's disease assessed by positron emission tomography.
Topics: Age Factors; Aged; Alzheimer Disease; Carbon Radioisotopes; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Female; Humans; Ligands; Male; Middle Aged; Tomography, Emission-Computed | 1998 |
Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations.
Topics: Animals; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Iodine Radioisotopes; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Papio; Radioligand Assay; Tomography, Emission-Computed | 1998 |
Synthesis and ligand binding of tropane ring analogues of paroxetine.
Topics: Binding, Competitive; Cocaine; Dopamine Uptake Inhibitors; Isomerism; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Paroxetine; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tropanes | 1998 |
Dopamine transporter development in postnatal rat striatum: an autoradiographic study with [3H]WIN 35,428.
Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tritium | 1997 |
Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals.
Topics: Animals; Body Weight; Brain; Carbon Radioisotopes; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Ligands; Mice; Piperazines; Pyridines; Raclopride; Radioactivity; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Salicylamides; Serotonin Antagonists; Tomography, Emission-Computed | 1998 |
[18F]CFT [(18F)WIN 35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects.
Topics: Adult; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluorine Radioisotopes; Humans; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Presynaptic Terminals; Sensitivity and Specificity; Tomography, Emission-Computed | 1998 |
Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims.
Topics: Adult; Aged; Aged, 80 and over; Caudate Nucleus; Cocaine; Depressive Disorder; Dopamine; Dopamine Uptake Inhibitors; Female; Humans; Ligands; Male; Middle Aged; Receptors, Dopamine; Suicide | 1997 |
Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain.
Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Iodine Radioisotopes; Ligands; Macaca fascicularis; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Receptors, Dopamine D1; Selective Serotonin Reuptake Inhibitors; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1998 |
Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Crystallography, X-Ray; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperidines; Protein Binding; Rats; Stereoisomerism; Synaptosomes; Tropanes | 1998 |
Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Molecular Conformation; Nerve Tissue Proteins; Protein Binding; Putamen; Rats; Stereoisomerism; Tropanes | 1998 |
Delineation of an endogenous zinc-binding site in the human dopamine transporter.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cocaine; Conserved Sequence; COS Cells; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Histidine; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Symporters; Zinc | 1998 |
Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.
Topics: Carrier Proteins; Cell Line; Cocaine; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Tritium | 1998 |
Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
Topics: Animals; Carrier Proteins; Cell Line; Citalopram; Cloning, Molecular; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Transfection | 1998 |
Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter.
Topics: Animals; Carrier Proteins; Cell Line; Cloning, Molecular; Cocaine; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phorbol Esters; Protein Kinase C; Recombinant Proteins; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection | 1998 |
Expression and regulation of the human dopamine transporter in a neuronal cell line.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Enzyme Activation; Gene Expression Regulation, Developmental; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Neurons; Paroxetine; Protein Kinases; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1998 |
Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428.
Topics: Adult; Amphetamine-Related Disorders; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Central Nervous System Stimulants; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Middle Aged; Neostriatum; Nerve Tissue Proteins; Parkinson Disease, Secondary; Propiophenones; Tomography, Emission-Computed | 1998 |
Specificity and ion dependence of binding of GBR analogs.
Topics: Animals; Carrier Proteins; Cell Fractionation; Cell Membrane; Centrifugation, Density Gradient; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tritium | 1998 |
Inhibition of [3H]dopamine translocation and [3H]cocaine analog binding: a potential screening device for cocaine antagonists.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Fractionation; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Design; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Rats; Sodium; Software; Tritium | 1998 |
Novel rhenium complexes derived from alpha-tropanol as potential ligands for the dopamine transporter.
Topics: Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Crystallography, X-Ray; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rhenium; Structure-Activity Relationship; Tropanes | 1998 |
Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine.
Topics: Animals; Cocaine; Discrimination Learning; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Pirenzepine; Rats; Rats, Sprague-Dawley; Time Factors; Tritium; Tropanes | 1999 |
Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1998 |
Dizocilpine and reduced body temperature do not prevent methamphetamine-induced neurotoxicity in the vervet monkey: [11C]WIN 35,428 - positron emission tomography studies.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Chlorocebus aethiops; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Hypothermia; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins; Neuroprotective Agents; Tomography, Emission-Computed | 1998 |
Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoreceptors; Brain Chemistry; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extracellular Space; Female; Homovanillic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Tritium | 1999 |
PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).
Topics: Adult; Aged; Brain Mapping; Carbon Radioisotopes; Cocaine; Corpus Striatum; Diagnosis, Differential; Dopamine; Dopamine Uptake Inhibitors; Dystonia; Female; Homovanillic Acid; Humans; Male; Middle Aged; Parkinson Disease; Parkinson Disease, Secondary; Pilot Projects; Receptors, Dopamine; Receptors, Presynaptic; Tomography, Emission-Computed | 1999 |
Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species?
Topics: Binding Sites; Bretylium Compounds; Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Guanethidine; Humans; Hydrogen-Ion Concentration; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons | 1999 |
Striatal dopaminergic abnormalities in human cocaine users.
Topics: Adolescent; Adult; Autoradiography; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Receptors, Dopamine; Severity of Illness Index; Tritium | 1999 |
Striatal uptake of a novel PET ligand, [18F]beta-CFT, is reduced in early Parkinson's disease.
Topics: Aged; Animals; Caudate Nucleus; Cocaine; Dopamine Uptake Inhibitors; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Parkinson Disease; Putamen; Tomography, Emission-Computed | 1999 |
Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat.
Topics: Age Factors; Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nomifensine; Nucleus Accumbens; Rats; Rats, Inbred F344; Substantia Nigra; Tritium; Ventral Tegmental Area | 1999 |
Modeling of the interaction of Na+ and K+ with the binding of dopamine and [3H]WIN 35,428 to the human dopamine transporter.
Topics: Algorithms; Binding, Competitive; Carrier Proteins; Cell Line; Chlorides; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Models, Neurological; Nerve Tissue Proteins; Potassium; Protein Binding; Sodium | 1999 |
Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists?
Topics: Algorithms; Amphetamine; Animals; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrodes; In Vitro Techniques; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Neostriatum; Nerve Tissue Proteins; Phenethylamines; Rats; Rats, Sprague-Dawley | 1999 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors.
Topics: Animals; Bridged Bicyclo Compounds; Cocaine; Cocaine-Related Disorders; Discrimination Learning; Dopamine; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Models, Molecular; Neostriatum; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Synaptosomes | 1999 |
Nongenomic steroidal modulation of high-affinity serotonin transport.
Topics: Animals; Carrier Proteins; Cell Line; Cocaine; Dose-Response Relationship, Drug; Estradiol; Humans; Ion Channels; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Receptors, Neurotransmitter; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tamoxifen; Time Factors | 1999 |
Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Depression, Chemical; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Papio; Piperazines; Self Administration; Tomography, Emission-Computed | 1999 |
Pharmacological profile of neuroleptics at human monoamine transporters.
Topics: Antipsychotic Agents; Carrier Proteins; Cell Line; Chlorpromazine; Cocaine; Dibenzazepines; Dibenzothiepins; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Pimozide; Piperazines; Protein Binding; Radioligand Assay; Recombinant Fusion Proteins; Serotonin Plasma Membrane Transport Proteins; Symporters; Thiazoles; Triflupromazine; Tritium | 1999 |
Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons.
Topics: Animals; Benzamides; Benzofurans; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Iodine Radioisotopes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Organotechnetium Compounds; Papio; Pyrrolidines; Raclopride; Radiopharmaceuticals; Receptors, Dopamine; Salicylamides; Tomography, Emission-Computed, Single-Photon; Tropanes | 1999 |
PET imaging of the dopamine transporter in progressive supranuclear palsy and Parkinson's disease.
Topics: Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Supranuclear Palsy, Progressive; Tomography, Emission-Computed | 1999 |
Alterations in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: compartment analysis for beta-CFT binding with positron emission tomography.
Topics: Aged; Amygdala; Binding Sites; Brain; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Frontal Lobe; Humans; Kinetics; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Orbit; Parkinson Disease; Radiography; Time Factors; Tomography, Emission-Computed | 1999 |
Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity.
Topics: Animals; Autoradiography; Biomarkers; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Isoquinolines; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Endings; Nerve Tissue Proteins; Neurons; Receptors, GABA-A; Sensitivity and Specificity; Substantia Nigra; Tritium; Tyrosine 3-Monooxygenase | 1999 |
Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Animals; Biomarkers; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Haplorhini; Humans; Macaca fascicularis; Magnetic Resonance Imaging; Male; Models, Biological; Parkinson Disease; Tomography, Emission-Computed; Visual Cortex | 1999 |
Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzazepines; Cocaine; Corpus Striatum; Dextroamphetamine; Dibenzocycloheptenes; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Haloperidol; In Vitro Techniques; Male; Mice; Motor Activity; Radioligand Assay; Thiazepines | 1999 |
Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia.
Topics: Animals; Carrier Proteins; Cocaine; Cricetinae; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dystonia; Immunohistochemistry; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Tegmentum Mesencephali; Tritium; Tyrosine 3-Monooxygenase | 1999 |
Apparent dopamine D1 and D2 receptors in the weaver mutant mouse: receptor binding and coupling to adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Autoradiography; Benzamides; Benzazepines; Cocaine; Corpus Striatum; Cyclic AMP; Dopamine; Dopamine Antagonists; Down-Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Limbic System; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Nucleus Accumbens; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Signal Transduction; Substantia Nigra; Tritium | 1999 |
Studies of selected phenyltropanes at monoamine transporters.
Topics: Adult; Aged; Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Putamen; Rats; Rats, Sprague-Dawley; Rhombencephalon; Serotonin Plasma Membrane Transport Proteins; Symporters; Tropanes | 1999 |
CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter.
Topics: Animals; Binding Sites; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Tropanes | 1999 |
Pharmacokinetics of radiotracers in human plasma during positron emission tomography.
Topics: Benzazepines; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cocaine; Dihydroxyphenylalanine; Dopamine Antagonists; Drug Interactions; Fluorine Radioisotopes; Humans; Nicotine; Raclopride; Radiopharmaceuticals; Selegiline; Tomography, Emission-Computed | 1999 |
Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.
Topics: Amphetamine; Animals; Behavior, Animal; Cell Transplantation; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Female; Magnetic Resonance Imaging; Microdialysis; Neurons; Rats; Rats, Sprague-Dawley; Striatonigral Degeneration; Sympathectomy, Chemical; Tomography, Emission-Computed | 1999 |
Presynaptic and postsynaptic dopaminergic binding densities in the nigrostriatal and mesocortical systems in early Parkinson's disease: a double-tracer positron emission tomography study.
Topics: Aged; Benzazepines; Brain; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Cerebellum; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Functional Laterality; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Putamen; Receptors, Dopamine D1; Reference Values; Substantia Nigra; Tomography, Emission-Computed | 1999 |
Alterations in serotonin receptors in the neostriatum of weaver mutant mice.
Topics: Amphetamines; Animals; Citalopram; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Mice; Mice, Neurologic Mutants; Mutation; Neostriatum; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Tritium | 1999 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes.
Topics: Animals; Benzoates; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Carrier Proteins; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters | 1999 |
Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain.
Topics: Anesthesia, Inhalation; Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Isoflurane; Kinetics; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Piperazines; Receptors, Dopamine D2; Time Factors; Tomography, Emission-Computed; Wakefulness | 1999 |
Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Structure, Tertiary; Structure-Activity Relationship; Zinc | 1999 |
Nitrogen-based drugs are not essential for blockade of monoamine transporters.
Topics: Animals; Binding Sites; Carrier Proteins; Citalopram; Cocaine; COS Cells; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nitrogen; Norepinephrine; Putamen; Radioligand Assay | 1996 |
Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Chlorocebus aethiops; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Growth Factors; Nerve Tissue Proteins; Neurotoxins; Putamen; Tomography, Emission-Computed | 2000 |
Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration.
Topics: Aged; Autoradiography; Benzamides; Cadaver; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Putamen; Receptors, Dopamine D2; Reference Values; Striatonigral Degeneration | 2000 |
Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects.
Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Nerve Tissue Proteins; Psychomotor Performance; Putamen; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tritium; Zimeldine | 2000 |
Striatal dopamine transporter binding in neuroleptic-naive patients with schizophrenia studied with positron emission tomography.
Topics: Adult; Antipsychotic Agents; Brain; Carrier Proteins; Caudate Nucleus; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Functional Laterality; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Schizophrenia; Tomography, Emission-Computed | 2000 |
Prediction of detached personality in healthy subjects by low dopamine transporter binding.
Topics: Adult; Age Factors; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Functional Laterality; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Multivariate Analysis; Nerve Tissue Proteins; Personality; Personality Inventory; Putamen; Tomography, Emission-Computed | 2000 |
Efficient HPLC separation of [11C]beta-CFT or [11C]beta-CIT from an N-desmethyl precursor on a semipreparative reversed phase ODS column.
Topics: Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cocaine | 2000 |
Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET.
Topics: Amphetamine; Animals; Apomorphine; Cerebrovascular Circulation; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Hemodynamics; Magnetic Resonance Imaging; Male; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Rotation; Stereotyped Behavior; Sympathectomy, Chemical; Sympatholytics; Tomography, Emission-Computed | 2000 |
2Beta-carbomethoxy-3beta-(4- and 2-[18F]fluoromethylphenyl)tropanes: specific probes for in vivo quantification of central dopamine transporter sites.
Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Chlorocebus aethiops; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Image Processing, Computer-Assisted; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Serotonin; Tomography, Emission-Computed; Tropanes | 1999 |
Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Injections, Intraventricular; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Symporters; Tropanes | 2000 |
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds; Carrier Proteins; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Macaca fascicularis; Male; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Tritium | 2000 |
Interaction of Na+, K+, and Cl- with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Allosteric Regulation; Amphetamine; Binding Sites; Biological Transport; Carrier Proteins; Cell Line; Chlorides; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Models, Chemical; Nerve Tissue Proteins; Octopamine; Potassium; Sodium; Tritium; Tyramine | 2000 |
Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression.
Topics: Amino Acid Sequence; Animals; Biological Transport, Active; Carrier Proteins; Cell Membrane; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Proline; Protein Conformation; Transfection | 2000 |
In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cocaine; Dopamine Agents; Dopamine Uptake Inhibitors; Indicators and Reagents; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Microscopy, Electron; Neostriatum; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Species Specificity; Synaptic Vesicles; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
Toward development of an in vitro model of methamphetamine-induced dopamine nerve terminal toxicity.
Topics: Animals; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fenfluramine; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Methamphetamine; Neostriatum; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Temperature; Time Factors | 2000 |
Importance of valine at position 152 for the substrate transport and 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding of dopamine transporter.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Biological Transport; Carrier Proteins; Cattle; Cocaine; COS Cells; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Isoleucine; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Valine | 2000 |
Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Biological Transport; Carrier Proteins; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Protein Conformation; Rats; Transfection; Tritium | 2000 |
Progression in Parkinson's disease: a positron emission tomography study with a dopamine transporter ligand [18F]CFT.
Topics: Aged; Antiparkinson Agents; Brain; Carrier Proteins; Caudate Nucleus; Cerebellum; Cocaine; Disease Progression; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluorine Radioisotopes; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Putamen; Time Factors; Tomography, Emission-Computed | 2000 |
Effects of oligonucleotide antisense to dopamine D(1A) receptor messenger RNA in a rodent model of levodopa-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Cocaine; Denervation; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dyskinesia, Drug-Induced; Gene Expression; Levodopa; Male; Oligonucleotides, Antisense; Oxidopamine; Phenotype; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Rotation; Substantia Nigra; Sympatholytics; Tritium | 2000 |
Ketamine decreased striatal [(11)C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Space; Ketamine; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Osmolar Concentration; Raclopride; Tomography, Emission-Computed | 2000 |
Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Amphetamine; Animals; Apomorphine; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Cytoprotection; Dopamine Plasma Membrane Transport Proteins; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Motor Activity; Nerve Tissue Proteins; Oligonucleotides, Antisense; Oxidopamine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tritium | 2000 |
Reinstatement of extinguished drug-taking behavior in rats: effect of the kappa-opioid receptor agonist, U69593.
Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Extinction, Psychological; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2000 |
Effect of cocaine, nomifensine, GBR 12909 and WIN 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine.
Topics: Animals; Artifacts; Calibration; Carbon; Coated Materials, Biocompatible; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electrochemistry; Electrodes, Implanted; Equipment Failure; Fluorocarbon Polymers; Male; Microelectrodes; Nomifensine; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2000 |
Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cholinergic Fibers; Cocaine; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Piperazines; Raclopride; Receptors, Dopamine D2; Scopolamine; Synapses; Tomography, Emission-Computed; Wakefulness | 2000 |
Binding of uptake blockers to the neuronal dopamine transporter: further investigation about cationic and anionic requirements.
Topics: Animals; Anions; Binding Sites; Cations; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Mazindol; Rats; Rats, Sprague-Dawley | 2000 |
RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro.
Topics: Binding Sites; Carrier Proteins; Cells, Cultured; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Tropanes | 2000 |
Column-switching HPLC for the analysis of plasma in PET imaging studies.
Topics: Chromatography, High Pressure Liquid; Cocaine; Dopamine Agents; Imidazoles; Isoquinolines; Ligands; Pyridines; Raclopride; Sensitivity and Specificity; Solvents; Tetrabenazine; Time Factors; Tomography, Emission-Computed; Urea | 2000 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Energy Metabolism; Female; Fluorodeoxyglucose F18; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Huntington Disease; In Situ Hybridization; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Spiperone; Substantia Nigra; Tomography, Emission-Computed; Tritium | 2000 |
Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Carrier Proteins; Cations; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Immunohistochemistry; Ions; Membrane Glycoproteins; Membrane Transport Proteins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Protein Conformation; Radioligand Assay; Signal Transduction; Tritium; Tryptophan | 2000 |
Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent.
Topics: Animals; Biological Transport; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrophysiology; Gene Expression Regulation; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oocytes; Radioligand Assay; Receptors, Dopamine D2; Transfection; Xenopus laevis | 2001 |
Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biological Transport; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Methamphetamine; Methylphenidate; Models, Biological; Nerve Tissue Proteins; Norepinephrine; Onium Compounds; Organophosphorus Compounds; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Synaptosomes | 2001 |
Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter.
Topics: Animals; Benzhydryl Compounds; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Ligands; Macaca mulatta; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Piperazines; Piperidines; Radioligand Assay; Tritium | 2001 |
Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter.
Topics: Amino Acid Substitution; Binding, Competitive; Carrier Proteins; Cell Line; Cell Membrane; Cocaine; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Binding | 2001 |
Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes.
Topics: Animals; Binding Sites; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrophysiology; Enzyme Inhibitors; Genistein; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oocytes; Phenols; Protein-Tyrosine Kinases; Transfection; Tritium; Tyrphostins; Xenopus laevis | 2001 |
Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes.
Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Sodium Chloride | 2001 |
Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Bridged Bicyclo Compounds; Chromatography, Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Hypericum; In Vitro Techniques; Male; Norepinephrine; Phloroglucinol; Plants, Medicinal; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes | 2001 |
[(18)F]FDOPA and [(18)F]CFT are both sensitive PET markers to detect presynaptic dopaminergic hypofunction in early Parkinson's disease.
Topics: Aged; Brain; Caudate Nucleus; Cocaine; Dihydroxyphenylalanine; Dopamine; Down-Regulation; Female; Fluorine Radioisotopes; Functional Laterality; Humans; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Predictive Value of Tests; Presynaptic Terminals; Putamen; Synaptic Transmission | 2001 |
Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys.
Topics: Animals; Autoradiography; Binding Sites; Carrier Proteins; Caudate Nucleus; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Densitometry; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intravenous; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Putamen; Self Administration; Tissue Distribution | 2001 |
Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents.
Topics: Animals; Antiparkinson Agents; Benztropine; Carrier Proteins; Cocaine; Discrimination, Psychological; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Muscarinic M1; Receptors, Muscarinic; Serotonin Plasma Membrane Transport Proteins; Symporters | 2001 |
Neurotransmitter transporters synthesis and degradation rates.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Half-Life; Injections, Intraventricular; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereotaxic Techniques; Tropanes | 2001 |
Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites.
Topics: Animals; Binding Sites; Carrier Proteins; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutamic Acid; Histidine; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Engineering; Protein Structure, Tertiary; Structure-Activity Relationship; Zinc | 2001 |
The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Carrier Proteins; Cell Line; Cocaine; Conserved Sequence; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Structure, Secondary; Radioligand Assay; Recombinant Proteins; Transfection; Tritium; Tryptophan | 2001 |
Sensitive measurement of positron emitters eluted from HPLC.
Topics: Animals; Bismuth; Chromatography, High Pressure Liquid; Cocaine; Humans; Mice; Mice, Inbred Strains; Pyrrolidines; Radiation Monitoring; Receptors, Dopamine; Salicylamides; Tomography, Emission-Computed | 2001 |
The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter.
Topics: Benztropine; Binding Sites; Binding, Competitive; Carrier Proteins; Cell Membrane; Cocaine; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Indicators and Reagents; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Models, Molecular; Nerve Tissue Proteins; Protein Conformation | 2001 |
Synthesis and pharmacology of site specific cocaine abuse treatment agents: a new synthetic methodology for methylphenidate analogs based on the Blaise reaction.
Topics: Animals; Biochemistry; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Drug Design; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methylphenidate; Molecular Structure; Rats; Structure-Activity Relationship | 2001 |
Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET.
Topics: Adult; Behavior, Addictive; Brain Chemistry; Brief Psychiatric Rating Scale; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Cerebellar Cortex; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins; Nucleus Accumbens; Prefrontal Cortex; Psychoses, Substance-Induced; Putamen; Substance-Related Disorders; Tomography, Emission-Computed | 2001 |
Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors.
Topics: Adrenergic Uptake Inhibitors; Animals; Benzazepines; Brain Chemistry; Clomipramine; Cocaine; Desipramine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; Male; Nomifensine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sulpiride | 2001 |
Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.
Topics: Benzhydryl Compounds; Brain; Carrier Proteins; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Design; Drug Evaluation, Preclinical; Isomerism; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperidines; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2001 |
Peptide derived from insulin with regulatory activity of dopamine transporter.
Topics: Aminobutyrates; Animals; Carrier Proteins; CHO Cells; Cloning, Molecular; Cocaine; Cricetinae; Dopamine Plasma Membrane Transport Proteins; GABA Plasma Membrane Transport Proteins; Insulin; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Microinjections; Nerve Tissue Proteins; Organic Anion Transporters; Peptides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra; Synaptosomes | 2001 |
Age-related changes in the N-methyl-D-aspartate receptor binding sites within the human basal ganglia.
Topics: Adult; Aged; Aging; Autoradiography; Basal Ganglia; Caudate Nucleus; Cause of Death; Cocaine; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Female; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Nucleus Accumbens; Putamen; Radioligand Assay; Receptors, N-Methyl-D-Aspartate | 2001 |
Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia.
Topics: Adult; Brain Mapping; Chronic Disease; Cocaine; Corpus Striatum; Dominance, Cerebral; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Psychiatric Status Rating Scales; Radioligand Assay; Schizophrenia; Tomography, Emission-Computed | 2001 |
2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies.
Topics: Animals; Brain; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2001 |
Synthesis and binding affinities of 2 beta-(3-iodoallyloxycarbonyl)-3 beta-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies.
Topics: Animals; Binding, Competitive; Biochemistry; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Inhibitory Concentration 50; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Structure-Activity Relationship; Tropanes | 2001 |
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.
Topics: Animals; Carbazoles; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Probes; Nerve Tissue Proteins; Piperazines; Rats | 2001 |
Novel tropane-based irreversible ligands for the dopamine transporter.
Topics: Animals; Azides; Benztropine; Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; In Vitro Techniques; Isothiocyanates; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Putamen; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tropanes | 2001 |
Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes.
Topics: Animals; Carrier Proteins; Central Nervous System Depressants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ethanol; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kinetics; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; Rats; Receptors, Cell Surface; RNA; Xenopus | 2001 |
Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain.
Topics: Anesthetics, Dissociative; Animals; Carbon Radioisotopes; Cerebrovascular Circulation; Cocaine; Contrast Media; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Ketamine; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nortropanes; Time Factors; Tomography, Emission-Computed | 2001 |
Cocaine induction of dopamine transporter trafficking to the plasma membrane.
Topics: Animals; Binding, Competitive; Biological Transport; Blotting, Western; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Phosphorylation; Radioligand Assay; RNA, Messenger; Second Messenger Systems; Serotonin; Subcellular Fractions; Transfection; Tritium; Tumor Cells, Cultured | 2002 |
Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.
Topics: Animals; Biological Transport; Body Temperature; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Hallucinogens; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neuropeptides; Neurotoxins; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Effects of GBR 12909, WIN 35,428 and indatraline on cocaine self-administration and cocaine seeking in rats.
Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Indans; Male; Methylamines; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Self Administration | 2002 |
Birth insult and stress interact to alter dopamine transporter binding in rat brain.
Topics: Aging; Animals; Brain; Cesarean Section; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fetal Hypoxia; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Reference Values; Stress, Physiological | 2002 |
Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Chlorocebus aethiops; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Drug Resistance; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Motor Proteins; Mutation; Nerve Tissue Proteins; Transfection; Tritium | 2002 |
Is Na(+) required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter?
Topics: Amphetamine; Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Octopamine; Sodium; Substrate Specificity; Tyramine | 2002 |
The functional domains of dopamine transporter for cocaine analog, CFT binding.
Topics: Animals; Cattle; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2002 |
Dopamine transport function is elevated in cocaine users.
Topics: Adult; Animals; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Cryopreservation; Delirium; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Papio; Postmortem Changes; Synaptosomes; Time Factors | 2002 |
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.
Topics: Binding Sites; Biphenyl Compounds; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Norepinephrine; Serotonin; Structure-Activity Relationship; Thiazoles | 2002 |
Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluorophenyl)tropane.
Topics: Binding, Competitive; Cations; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Interactions; Humans; Lithium; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Potassium; Protons; Sodium | 2002 |
Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys.
Topics: Aging; Animals; Benzazepines; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Extracellular Space; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Male; Microdialysis; Piperazines; Raclopride; Tomography, Emission-Computed | 2002 |
Biodistribution study of [99mTc] TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautoradiography.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain; Cocaine; Dopamine Agents; Humans; Levodopa; Male; Methylphenidate; Mice; Mice, Inbred ICR; Organotechnetium Compounds; Parkinson Disease; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution; Tropanes | 2002 |
Effects of SCH 23390 and eticlopride on cocaine-seeking produced by cocaine and WIN 35,428 in rats.
Topics: Animals; Behavior, Addictive; Benzazepines; Cocaine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides | 2003 |
Ceramide-induced alterations in dopamine transporter function.
Topics: Animals; Binding, Competitive; Ceramides; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Serotonin; Synaptosomes; Tritium | 2003 |
Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cell Membrane; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Isoindoles; Macaca mulatta; Male; Mazindol; Mice; Motor Activity; Neurotransmitter Agents; Proadifen; Rats; Rats, Sprague-Dawley; Tritium | 2003 |
Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats.
Topics: Amphetamine; Animals; Blood Glucose; Cocaine; Diabetes Mellitus, Experimental; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Eating; Insulin; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Pancrelipase; Rats; Rats, Sprague-Dawley; Self Administration; Streptozocin; Synaptosomes | 2003 |
Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter.
Topics: Amino Acid Sequence; Animals; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extracellular Space; Humans; Indicators and Reagents; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Conformation; Protein Structure, Tertiary; Radioligand Assay; Sodium; Tritium; Zinc | 2003 |
Age-related changes of the [11C]CFT binding to the striatal dopamine transporters in the Fischer 344 rats: a PET study.
Topics: Age Factors; Aging; Animals; Carbon Radioisotopes; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Metabolic Clearance Rate; Nerve Tissue Proteins; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tissue Distribution | 2003 |
Na+ stimulates binding of dopamine to the dopamine transporter in cells but not in cell-free preparations.
Topics: Binding, Competitive; Cell Line; Cell Membrane; Cell-Free System; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Kidney; Meglumine; Membrane Glycoproteins; Membrane Potentials; Membrane Transport Proteins; Nerve Tissue Proteins; Potassium; Sodium; Sucrose | 2003 |
Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Binding Sites; Body Temperature; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Homovanillic Acid; Male; Methamphetamine; Motor Activity; Neostriatum; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Tetrabenazine; Time Factors; Tritium | 2003 |
Acquisition of an appetitive behavior prevents development of stress-induced neurochemical modifications in rat nucleus accumbens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Analysis of Variance; Animals; Appetite; Behavior, Animal; Benzazepines; Binding Sites; Brain Chemistry; Carbohydrates; Cell Count; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Escape Reaction; Male; Maze Learning; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stress, Physiological; Time Factors; Tritium; Vanilla | 2003 |
Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter.
Topics: Animals; Binding Sites; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Exploratory Behavior; Head; Individuality; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Time Factors | 2003 |
Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms.
Topics: Adult; Amphetamine-Related Disorders; Amygdala; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Frontal Lobe; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins; Prefrontal Cortex; Psychoses, Substance-Induced; Tomography, Emission-Computed | 2003 |
Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT.
Topics: Adolescent; Adult; Case-Control Studies; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Narcolepsy; Nerve Tissue Proteins; Putamen; Tomography, Emission-Computed | 2004 |
Binding of cocaine-like radioligands to the dopamine transporter at 37 degrees C: effect of Na+ and substrates.
Topics: Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nortropanes; Radioligand Assay; Sodium; Temperature; Tritium | 2003 |
Structure-activity relationships for substrate recognition by the human dopamine transporter.
Topics: Binding, Competitive; Biological Transport; Cells, Cultured; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Structure-Activity Relationship | 2004 |
The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Half-Life; Male; Rats; Rats, Sprague-Dawley; Satiety Response; Self Administration | 2004 |
Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands.
Topics: Animals; Antiparkinson Agents; Benztropine; Cocaine; Discrimination Learning; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley | 2004 |
Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats.
Topics: Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Binding Sites; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrochemistry; In Situ Hybridization; Male; Maternal Deprivation; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Dopamine; RNA, Messenger; Stress, Psychological; Tetrahydronaphthalenes; Tritium | 2004 |
Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.
Topics: Amino Acid Substitution; Benztropine; Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kidney; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Muscarinic Antagonists; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Piperazines; Protein Binding; Sodium; Structure-Activity Relationship; Zinc | 2004 |
Reinforcing effect of pseudoephedrine isomers and the mechanism of action.
Topics: Animals; Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ephedrine; Humans; Infusion Pumps; Isomerism; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Serotonin Plasma Membrane Transport Proteins; Symporters; Tritium | 2004 |
Role of the dopamine transporter in the differential cocaine-induced locomotor activation of inbred long-sleep and short-sleep mice.
Topics: Animals; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrochemistry; Habituation, Psychophysiologic; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Motor Activity; Neostriatum; Nerve Tissue Proteins; Sleep | 2004 |
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain; Carbon Radioisotopes; Cocaine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dopamine Uptake Inhibitors; Hazardous Substances; Humans; Inclusion Bodies; Male; Molecular Structure; Multienzyme Complexes; Oligopeptides; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed | 2004 |
Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Blotting, Northern; Brain; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Illicit Drugs; Male; Metallothionein; Methamphetamine; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Time Factors | 2004 |
Mapping dopamine function in primates using pharmacologic magnetic resonance imaging.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Brain; Brain Mapping; Cerebrovascular Circulation; Cocaine; Dopamine; Dopamine Agents; Macaca fascicularis; Magnetic Resonance Imaging; Motor Activity; Parkinsonian Disorders; Positron-Emission Tomography; Radioligand Assay | 2004 |
Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.
Topics: Alkenes; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2004 |
Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Binding Sites; Binding, Competitive; Biological Transport; Cell Line; Cell Membrane; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutation; Nerve Tissue Proteins; Norepinephrine; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism; Synaptosomes; Tritium | 2004 |
Enhanced binding of dopamine D1 receptors in caudate-putamen subregions in High-Yawning Sprague-Dawley rats.
Topics: Animals; Benzazepines; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Male; Neostriatum; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Spiperone; Tritium; Yawning | 2005 |
Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE.
Topics: Carbon Radioisotopes; Chemical Fractionation; Choline; Chromatography, High Pressure Liquid; Cocaine; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals | 2005 |
Involvement of dopamine receptors in cocaine-induced genital reflexes after paradoxical sleep deprivation.
Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Brain; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Penile Erection; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine; Sleep Deprivation; Sleep, REM; Tritium | 2005 |
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Mapping; Clonidine; Cocaine; Cognition Disorders; Discrimination Learning; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluoxetine; Macaca mulatta; Male; Membrane Proteins; Memory; Nerve Tissue Proteins; Neuropsychological Tests; Prazosin; Prefrontal Cortex; Radioligand Assay; Receptors, Catecholamine; Statistics as Topic; Tritium | 2005 |
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Benztropine; Binding, Competitive; CHO Cells; Cocaine; Cricetinae; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Immunohistochemistry; Kinetics; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Microscopy, Confocal; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Transfection | 2005 |
Acute NMDA receptor antagonism induces biphasic striatal utilization of L-[beta-11C]DOPA: PET studies in the conscious monkey brain.
Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Cocaine; Consciousness; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Macaca mulatta; Male; Neural Pathways; Positron-Emission Tomography; Presynaptic Terminals; Raclopride; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter.
Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Proline; Thermodynamics; Tyramine | 2005 |
Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs.
Topics: Animals; Benztropine; Binding, Competitive; Brain; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Guanidines; Histamine; Histamine Agonists; Histamine H1 Antagonists; In Vitro Techniques; Male; Methylhistamines; Motor Activity; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Tropanes | 2005 |
Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates.
Topics: Analysis of Variance; Animals; Binding, Competitive; Calcium; Cell Line; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Gramicidin; Humans; Male; Membrane Potentials; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sodium; Synaptosomes; Tritium | 2005 |
Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation.
Topics: Amphetamine; Animals; Biotin; Biotinylation; Cell Line; Cocaine; Corpus Striatum; Diagnostic Imaging; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Administration Schedule; Electrophoresis, Polyacrylamide Gel; Endocytosis; Exocytosis; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Protein Binding; Protein Transport; Rats; Subcellular Fractions; Synaptosomes; Time Factors; Transfection; Tritium | 2005 |
Acute manganese administration alters dopamine transporter levels in the non-human primate striatum.
Topics: Animals; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Male; Manganese; Manganese Compounds; Membranes; Neostriatum; Papio; Positron-Emission Tomography; Presynaptic Terminals; Rats; Rats, Long-Evans; Sulfates | 2006 |
HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: changes in dopamine transporter binding and immunoreactivity.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Epitopes; Female; Gene Products, tat; HIV-1; Immunohistochemistry; Mesencephalon; Neurons; Neurotoxins; Phosphopyruvate Hydratase; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; tat Gene Products, Human Immunodeficiency Virus | 2006 |
Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine.
Topics: Animals; Benzylamines; Binding, Competitive; Cocaine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Norepinephrine Plasma Membrane Transport Proteins; Pyrans; Rats; Reference Standards; Sensitivity and Specificity; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2006 |
Characterization of the neuronal dopamine transporter DAT in human blood platelets.
Topics: Blood Platelets; Blotting, Northern; Blotting, Western; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins | 2006 |
Dopamine uptake and cocaine binding mechanisms: the involvement of charged amino acids from the transmembrane domains of the human dopamine transporter.
Topics: Alanine; Amino Acid Substitution; Animals; Arginine; Binding Sites; Binding, Competitive; Chlorocebus aethiops; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kinetics; Lysine; Mutation; Transfection; Tritium | 2006 |
3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; CHO Cells; Citalopram; Cocaine; Cricetinae; Dopamine Plasma Membrane Transport Proteins; Humans; Ligands; Models, Molecular; Molecular Conformation; Recombinant Proteins; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Tropanes | 2006 |
One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter.
Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Brain; Cocaine; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Rats; Rats, Sprague-Dawley; Self Administration; Time Factors; Tritium | 2006 |
Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Brain-Derived Neurotrophic Factor; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Gene Expression Regulation; Levodopa; Male; Oxidopamine; Parkinson Disease; Protein Binding; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Subthalamic Nucleus; Tritium | 2006 |
Binding of 3H-WIN-35,428 and 125I-RTI-121 to human platelet membranes.
Topics: Adult; Blood Platelets; Cell Membrane; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; In Vitro Techniques; Iodine Radioisotopes; Ligands; Male; Protein Binding | 2006 |
Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo.
Topics: Animals; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Macaca fascicularis; Male; Parkinsonian Disorders; Quinolines; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2006 |
Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Amphetamine-Related Disorders; Animals; Body Temperature; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Male; Methamphetamine; Microdialysis; Neostriatum; Rats; Rats, Sprague-Dawley | 2006 |
Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors.
Topics: Aconitine; Analysis of Variance; Animals; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Male; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Nicotinic Antagonists; Radioligand Assay; Reactive Oxygen Species; Receptors, Nicotinic; Synaptosomes; Tritium | 2006 |
In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus.
Topics: Aged; Cerebral Ventricles; Cocaine; Cognition; Dopamine; Dopamine Antagonists; Female; Humans; Hydrocephalus, Normal Pressure; Magnetic Resonance Imaging; Male; Memory; Mesencephalon; Middle Aged; Neostriatum; Neuropsychological Tests; Nucleus Accumbens; Positron-Emission Tomography; Presynaptic Terminals; Putamen; Raclopride; Receptors, Dopamine D2; Synapses | 2007 |
Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Caudate Nucleus; Chromatography, Thin Layer; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Indicators and Reagents; Macaca fascicularis; Macaca mulatta; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Oxidation-Reduction; Putamen; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2007 |
Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier.
Topics: Adult; Carbon Radioisotopes; Cocaine; Dopamine; Dopamine Antagonists; Gaucher Disease; Heterozygote; Humans; Male; Neurons; Parkinson Disease; Positron-Emission Tomography; Raclopride | 2007 |
CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Cannabinoids; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Synaptosomes | 2007 |
Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dieldrin; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutathione; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Oxidative Stress; Protein Carbonylation; Substantia Nigra | 2007 |
Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies.
Topics: Adrenergic Agents; Animals; Brain; Cocaine; Functional Laterality; Image Processing, Computer-Assisted; Male; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2007 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Male; Methylphenidate; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship | 2007 |
Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease.
Topics: Aged; Cocaine; Corpus Striatum; Denervation; Dopamine; Dopamine Uptake Inhibitors; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Olfaction Disorders; Parkinson Disease; Positron-Emission Tomography; Substantia Nigra | 2007 |
Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter.
Topics: Animals; Binding, Competitive; Biological Transport; Cell Survival; CHO Cells; Cocaine; Cricetinae; Cricetulus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Motor Activity; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Plant Extracts; Psoralea; Rats; Reserpine; Seeds; Synaptosomes; Transfection | 2007 |
Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats.
Topics: Animals; Carbon Radioisotopes; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Hippocampus; Immunohistochemistry; Male; Nerve Degeneration; Neurons; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Pyridines; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of Parkinson disease.
Topics: Analysis of Variance; Animals; Autoradiography; Cell Transplantation; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine Uptake Inhibitors; Extremities; Functional Laterality; Humans; Male; Motor Neuron Disease; Parkinson Disease; Pigment Epithelium of Eye; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Time Factors; Transplantation, Heterologous | 2007 |
Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles.
Topics: Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain; Brain Chemistry; Central Nervous System Stimulants; Chlorocebus aethiops; Cocaine; Disease Models, Animal; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Methamphetamine; Neurotoxicity Syndromes; Protein Binding; Raclopride; Social Behavior; Tritium | 2008 |
Individual differences in response to novelty predict prefrontal cortex dopamine transporter function and cell surface expression.
Topics: Aconitine; Animals; Behavior, Animal; Binding, Competitive; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Exploratory Behavior; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenotype; Prefrontal Cortex; Presynaptic Terminals; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Synaptosomes; Tobacco Use Disorder | 2007 |
Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease.
Topics: Aged; Biomarkers; Cocaine; Female; Humans; Isotopes; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Psychomotor Performance; Striatonigral Degeneration | 2007 |
Parkin disrupts the alpha-synuclein/dopamine transporter interaction: consequences toward dopamine-induced toxicity.
Topics: alpha-Synuclein; Binding Sites; Cell Line; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kidney; Kinetics; Microscopy, Confocal; Transfection; Ubiquitin-Protein Ligases | 2007 |
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.
Topics: Alanine; Amino Acid Substitution; Animals; Biological Transport; Chlorocebus aethiops; Cocaine; COS Cells; Data Interpretation, Statistical; Discrimination Learning; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Male; Mesylates; Motor Activity; Protein Binding; Protein Conformation; Rats; Rats, Sprague-Dawley; Transfection | 2008 |
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.
Topics: Animals; Autoradiography; Brain; Carbon Isotopes; Carrier Proteins; Cocaine; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Glial Fibrillary Acidic Protein; Isoquinolines; Male; Neurons; Papio anubis; Parkinsonian Disorders; Positron-Emission Tomography; Raclopride; Tetrabenazine; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2008 |
Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users.
Topics: Adult; Amphetamine-Related Disorders; Analysis of Variance; Cocaine; Cognition; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Female; Humans; Male; Methamphetamine; Middle Aged; Neuropsychological Tests; Parkinson Disease, Secondary; Positron-Emission Tomography | 2008 |
Presence and characterization of the dopamine transporter in human resting lymphocytes.
Topics: Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Lymphocytes; Male; Tritium | 2008 |
Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade.
Topics: Animals; Autoradiography; Brain Chemistry; Cocaine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Female; In Situ Hybridization; Phencyclidine; Pregnancy; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tyrosine 3-Monooxygenase | 2008 |
Ex vivo evaluation of N-(3-[18F]fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-fluorophenyl)nortropane in rats.
Topics: Animals; Binding, Competitive; Bone and Bones; Cerebellum; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluorine Radioisotopes; Limbic System; Male; Nortropanes; Piperazines; Radioligand Assay; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2008 |
The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Chlorocebus aethiops; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Structure-Activity Relationship; Time Factors; Transfection | 2008 |
Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Embryo, Mammalian; HIV Envelope Protein gp120; Mesencephalon; Neurons; Piperazines; Protein Binding; Rats; Serotonin Plasma Membrane Transport Proteins; tat Gene Products, Human Immunodeficiency Virus | 2008 |
Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Autoradiography; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Extinction, Psychological; Male; Multivariate Analysis; Protein Binding; Random Allocation; Rats; Rats, Inbred Lew; Reinforcement, Psychology; Self Administration; Time Factors; Tritium | 2008 |
Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys.
Topics: Animals; Benzazepines; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Raclopride; Receptors, Dopamine D1; Self Administration; Tritium | 2009 |
Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.
Topics: Animals; Asparagine; Aspartic Acid; Benztropine; Binding, Competitive; Cell Line, Transformed; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Leucine; Models, Molecular; Mutation; Piperazines; Protein Binding; Protein Structure, Tertiary; Sodium; Structure-Activity Relationship; Transfection; Tritium; Tryptophan | 2008 |
Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity.
Topics: Aged; Carbon Isotopes; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Female; Hippocampus; Humans; Male; Mental Status Schedule; Middle Aged; Models, Biological; Neural Pathways; Olfaction Disorders; Parkinson Disease; Radionuclide Imaging | 2008 |
Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner.
Topics: Amphetamine; Animals; Binding, Competitive; Cell Line; Chlorides; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Histidine; Humans; Lysine; Male; Membrane Potentials; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Patch-Clamp Techniques; Protein Binding; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Trace Elements; Transfection; Zinc Sulfate | 2009 |
Dopaminergic neurons derived from BG01V2, a variant of human embryonic stem cell line BG01.
Topics: Actins; Bromodeoxyuridine; Cell Differentiation; Cell Line; Cell Proliferation; Chromosomes, Human, Pair 17; Cocaine; Coculture Techniques; Dopamine; Dopamine Plasma Membrane Transport Proteins; Embryonic Stem Cells; Humans; Membrane Potentials; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Otx Transcription Factors; Patch-Clamp Techniques; Protein Binding; Time Factors; Tritium; Tyrosine 3-Monooxygenase | 2008 |
Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatum.
Topics: Adult; Age Factors; Aged; Aging; Carbon Isotopes; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Raclopride; Receptors, Dopamine D2; Young Adult | 2009 |
In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex.
Topics: Animals; Cerebral Cortex; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Estradiol; Fluoxetine; Gonadal Hormones; Male; Norepinephrine Plasma Membrane Transport Proteins; Orchiectomy; Protein Binding; Rats; Rats, Sprague-Dawley; Testosterone Propionate; Time Factors; Tritium | 2009 |
Dopamine transporter binding in rat striatum: a comparison of [O-methyl-11C]beta-CFT and [N-methyl-11C]beta-CFT.
Topics: Animals; Carbon Radioisotopes; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Neostriatum; Nitrogen; Oxygen; Positron-Emission Tomography; Protein Binding; Radiochemistry; Rats; Rats, Sprague-Dawley | 2009 |
Decreased brain dopamine cell numbers in human cocaine users.
Topics: Adolescent; Adult; Analysis of Variance; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Count; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Female; Humans; Male; Mesencephalon; Middle Aged; Neurons; Plant Lectins; Protein Binding; Tritium; Tyrosine 3-Monooxygenase; Young Adult | 2009 |
Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Cocaine; Disease Models, Animal; Dopamine; Dopamine Agents; Embryonic Stem Cells; Levodopa; Macaca fascicularis; Methamphetamine; Movement Disorders; Neurons; Parkinson Disease; Positron-Emission Tomography; Putamen; Raclopride; Tyrosine 3-Monooxygenase | 2009 |
In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Cell Line; CHO Cells; Cocaine; Cricetinae; Cricetulus; Dopamine; Dopamine Agents; Humans; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Norepinephrine; Parkinson Disease; Phenols; Psoralea; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase | 2009 |
HIV-1 Tat protein-induced rapid and reversible decrease in [3H]dopamine uptake: dissociation of [3H]dopamine uptake and [3H]2beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (WIN 35,428) binding in rat striatal synaptosomes.
Topics: Animals; Binding Sites; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Leucine; Male; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Surface Plasmon Resonance; Synaptosomes; tat Gene Products, Human Immunodeficiency Virus | 2009 |
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs.
Topics: Alanine; Animals; Animals, Newborn; Cells, Cultured; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dynamins; Enzyme Inhibitors; Fluorescence Recovery After Photobleaching; Green Fluorescent Proteins; Humans; Indoles; Lysine; Maleimides; Mesencephalon; Mutation; Neurons; Phorbol Esters; Protein Transport; rab5 GTP-Binding Proteins; Rats; Receptors, Transferrin; Time Factors; Transfection; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2009 |
Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity.
Topics: Animals; Benztropine; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Microdialysis; Nucleus Accumbens | 2009 |
Expanding the clinical phenotype of SNCA duplication carriers.
Topics: Adult; Aged; alpha-Synuclein; Brain; Carbon Isotopes; Chromosome Mapping; Cocaine; Family Health; Female; Fluorodeoxyglucose F18; Gene Dosage; Gene Duplication; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Parkinson Disease; Phenotype; Positron-Emission Tomography; Raclopride; REM Sleep Behavior Disorder; Sensory Thresholds; Smell; Young Adult | 2009 |
Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.
Topics: Animals; Cells, Cultured; Cocaine; Corpus Striatum; Cyclin-Dependent Kinase 5; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Humans; Indoles; Male; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Swine; Synaptosomes | 2009 |
Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings.
Topics: Adult; Aged; Ataxin-3; Ataxins; Carbon Isotopes; China; Cocaine; DNA Mutational Analysis; Family Health; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins; Nuclear Proteins; Parkinson Disease; Positron-Emission Tomography; Repressor Proteins; Trinucleotide Repeat Expansion | 2009 |
Evaluation of nigrostriatal damage and its change over weeks in a rat model of Parkinson's disease: small animal positron emission tomography studies with [(11)C]beta-CFT.
Topics: Animals; Carbon Radioisotopes; Cocaine; Corpus Striatum; Disease Models, Animal; Humans; Male; Parkinsonian Disorders; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar | 2009 |
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Ethylamines; Guanidines; Male; Morpholines; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement Schedule; Reward; Self Administration | 2010 |
Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders.
Topics: Adolescent; Adult; Antipsychotic Agents; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Lymphocytes; Male; Protein Binding; Psychotic Disorders; Statistics as Topic; Tritium; Young Adult | 2010 |
Objective and quantitative evaluation of motor function in a monkey model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Mapping; Carbon Radioisotopes; Cocaine; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Macaca fascicularis; Parkinsonian Disorders; Positron-Emission Tomography; Severity of Illness Index; Video Recording | 2010 |
Progression from unilateral to bilateral parkinsonism in early Parkinson disease: implication of mesocortical dopamine dysfunction by PET.
Topics: Adult; Aged; Cerebral Cortex; Cocaine; Disease Progression; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Regression Analysis | 2010 |
Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.
Topics: Adrenergic Uptake Inhibitors; Animals; Benztropine; Binding, Competitive; Cell Line, Tumor; Cell Membrane; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Histamine H1 Antagonists; Humans; Kinetics; Male; Mice; Mice, 129 Strain; Mice, Inbred Strains; Mice, Knockout; Neuroblastoma; Piperazines; Pirenzepine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Selective Serotonin Reuptake Inhibitors; Sodium; Triprolidine | 2010 |
Comparative neurochemical profile of 3,4-methylenedioxymethamphetamine and its metabolite alpha-methyldopamine on key targets of MDMA neurotoxicity.
Topics: Animals; Cell Membrane; Cell Survival; Cocaine; Deoxyepinephrine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Paroxetine; PC12 Cells; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes | 2011 |
Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.
Topics: Amphetamine; Benztropine; Binding Sites; Biotinylation; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Fluoxetine; HEK293 Cells; Humans; Immunoblotting; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Pharmacokinetics; Protein Conformation | 2011 |
Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Environment; Male; Methylphenidate; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2011 |
Effects of hypoxic-ischemic brain injury on striatal dopamine transporter in newborn piglets: evaluation of 11C-CFT PET/CT for DAT quantification.
Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Case-Control Studies; Cocaine; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Hypoxia-Ischemia, Brain; Male; Multimodal Imaging; Positron-Emission Tomography; Swine; Tomography, X-Ray Computed | 2011 |
Striatal dopamine transporter availability in unmedicated bipolar disorder.
Topics: Adolescent; Adult; Bipolar Disorder; Carbon Isotopes; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Psychiatric Status Rating Scales; Young Adult | 2011 |
Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.
Topics: Animals; Anisoles; Antipsychotic Agents; Carbazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Molecular Targeted Therapy; Oxalates; Piperidines; Propylamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement, Psychology; Self Administration | 2011 |
Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.
Topics: Binding, Competitive; Cocaine; Fluoxetine; HEK293 Cells; Humans; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Radiopharmaceuticals; Tritium | 2012 |
Serotonergic modulation of receptor occupancy in rats treated with L-DOPA after unilateral 6-OHDA lesioning.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antiparkinson Agents; Autoradiography; Carbon Isotopes; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Dyskinesia, Drug-Induced; Female; Functional Laterality; Levodopa; Microdialysis; Motor Activity; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Serotonergic Neurons; Serotonin Receptor Agonists | 2012 |
Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.
Topics: Bridged Bicyclo Compounds; Carboxylic Acids; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Esters; Humans; Molecular Structure; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2012 |
Benign hereditary chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation.
Topics: Adult; Brain; Brain Mapping; Chorea; Cocaine; DNA Mutational Analysis; Dopamine; Dopamine Antagonists; Family Health; Female; Humans; Male; Middle Aged; Mutation; Nuclear Proteins; Positron-Emission Tomography; Raclopride; Thyroid Nuclear Factor 1; Transcription Factors | 2013 |
The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey.
Topics: Animals; Carbon Radioisotopes; Cocaine; Corpus Striatum; Deep Brain Stimulation; Dihydroxyphenylalanine; Dopamine; Feeding Behavior; Hypokinesia; Macaca fascicularis; Magnetic Resonance Imaging; Male; MPTP Poisoning; Psychomotor Performance; Radionuclide Imaging; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Subthalamic Nucleus; Time Factors; Treatment Outcome; Tremor | 2012 |
Imaging striatal dopaminergic function in phospholipase A2 group VI-related parkinsonism.
Topics: Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Group VI Phospholipases A2; Humans; Male; Parkinsonian Disorders; Positron-Emission Tomography; Young Adult | 2012 |
Validation of nigrostriatal positron emission tomography measures: critical limits.
Topics: Animals; Cocaine; Corpus Striatum; Disease Models, Animal; Fluorodeoxyglucose F18; Macaca mulatta; Magnetic Resonance Imaging; Male; MPTP Poisoning; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Reproducibility of Results; Substantia Nigra; Tetrabenazine | 2013 |
Mice expressing markedly reduced striatal dopamine transporters exhibit increased locomotor activity, dopamine uptake turnover rate, and cocaine responsiveness.
Topics: Animals; Biological Transport, Active; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Gene Deletion; Locomotion; Mice; Protein Binding; Tyrosine 3-Monooxygenase | 2013 |
Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys.
Topics: Analgesics; Analysis of Variance; Animals; Benzylamines; Brain; Carbon Isotopes; Cocaine; Consciousness; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluorodeoxyglucose F18; Image Processing, Computer-Assisted; Ketamine; Macaca mulatta; Magnetic Resonance Imaging; Male; Microdialysis; Positron-Emission Tomography; Serotonin Plasma Membrane Transport Proteins | 2013 |
Non-dioxin-like PCBs inhibit [(3)H]WIN-35,428 binding to the dopamine transporter: a structure-activity relationship study.
Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Environmental Pollutants; Inhibitory Concentration 50; Male; Models, Chemical; Polychlorinated Biphenyls; Principal Component Analysis; Protein Binding; Rats; Rats, Wistar; Structure-Activity Relationship; Synaptosomes; Tritium | 2013 |
Relation between microPET imaging and rotational behavior in a parkinsonian rat model induced by medial forebrain bundle axotomy.
Topics: Animals; Apomorphine; Axotomy; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Functional Laterality; Male; Medial Forebrain Bundle; Parkinson Disease; Raclopride; Radionuclide Imaging; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2014 |
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity.
Topics: Animals; Antidepressive Agents; Citalopram; Cocaine; Depression; Disease Models, Animal; Female; Fluoxetine; Male; Medicine, Chinese Traditional; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Rats; Rats, Sprague-Dawley; Saponins; Swimming; Tritium | 2014 |
In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Count; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Functional Laterality; Macaca; Male; Neurons; Parkinsonian Disorders; Positron-Emission Tomography; Protein Binding; Substantia Nigra; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2014 |
Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinities.
Topics: Binding, Competitive; Biotinylation; Cocaine; Computer Simulation; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mutation; Protein Binding; Protein Subunits; Regression Analysis; Structure-Activity Relationship; Transfection; Tritium | 2015 |
Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport.
Topics: Animals; Binding Sites; CHO Cells; Cocaine; Cricetinae; Cricetulus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Lysine; Models, Molecular; Mutation; Piperazines; Protein Binding; Protein Conformation; tat Gene Products, Human Immunodeficiency Virus; Tyrosine | 2015 |
Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Binding, Competitive; Caudate Nucleus; Cocaine; Dextroamphetamine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Male; Rats; Synaptosomes | 2015 |
HIV-1 transgenic rats display an increase in [(3)H]dopamine uptake in the prefrontal cortex and striatum.
Topics: AIDS Dementia Complex; Animals; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Gene Expression; HIV-1; Kinetics; Male; Prefrontal Cortex; Rats; Rats, Inbred F344; Rats, Transgenic; Synaptosomes; tat Gene Products, Human Immunodeficiency Virus; Tritium | 2016 |
Onset-related subtypes of Parkinson's disease differ in the patterns of striatal dopaminergic dysfunction: A positron emission tomography study.
Topics: Adult; Age of Onset; Aged; Carbon Radioisotopes; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Female; Humans; Male; Middle Aged; Neuroimaging; Organ Specificity; Parkinson Disease; Positron-Emission Tomography; Putamen; Radiopharmaceuticals; Tissue Distribution | 2015 |
Suite PET/CT neuroimaging for the diagnosis of Parkinson's disease: statistical parametric mapping analysis.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Mapping; Case-Control Studies; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Fluorodeoxyglucose F18; Functional Neuroimaging; Glucose; Humans; Male; Middle Aged; Molecular Imaging; Parkinson Disease; Positron Emission Tomography Computed Tomography; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Young Adult | 2017 |
Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats.
Topics: Administration, Oral; Animals; Autoradiography; Benzazepines; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Methylphenidate; Radiopharmaceuticals; Rats, Inbred SHR; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tritium | 2017 |
Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Locomotion; Mice; Mice, Inbred C57BL; Mice, Knockout; Reward; RGS Proteins; Signal Transduction; Ventral Striatum | 2018 |
Multi-modality molecular imaging characteristics of dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Aniline Compounds; Cocaine; Dopamine Plasma Membrane Transport Proteins; Female; Fluorodeoxyglucose F18; Humans; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Imaging; Multimodal Imaging; Neuroimaging; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2018 |
Tamoxifen Directly Interacts with the Dopamine Transporter.
Topics: Amphetamine; Animals; Binding Sites; Cell Line; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Rats; Swine; Synaptosomes; Tamoxifen | 2018 |
Hypnic Headache with Dopaminergic Neuron Dysfunction: New Insight from a Rare Case.
Topics: Benserazide; Brain; Cocaine; Dopamine Agents; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Drug Combinations; Fluorodeoxyglucose F18; Headache Disorders, Primary; Humans; Levodopa; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Putamen; Radiopharmaceuticals | 2019 |
Positron emission tomography/computed tomography dual imaging using 18-fluorine flurodeoxyglucose and 11C-labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane for the severity assessment of Parkinson disease.
Topics: Aged; Basal Ganglia; Brain; Carbon Radioisotopes; Cocaine; Female; Fluorine Radioisotopes; Glucose; Humans; Male; Middle Aged; Parkinson Disease; Positron Emission Tomography Computed Tomography; Prospective Studies; Severity of Illness Index | 2020 |
Rate of onset of dopamine transporter inhibitors assessed with intracranial self-stimulation and in vivo dopamine photometry in rats.
Topics: Animals; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Stimulation | 2023 |