cocaethylene has been researched along with cocaine in 265 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 141 (53.21) | 18.2507 |
| 2000's | 60 (22.64) | 29.6817 |
| 2010's | 49 (18.49) | 24.3611 |
| 2020's | 15 (5.66) | 2.80 |
| Authors | Studies |
|---|---|
| Bunn, WH; Giannini, AJ | 1 |
| Hudzik, TJ; Lattin, DL; McMillan, DE; Shelnutt, S | 1 |
| Bosron, WF; Dean, RA; Dumaual, N; Harper, ET; Stoeckel, DA | 1 |
| Eskelson, CD; Pirozhkov, SV; Watson, RR | 1 |
| Dewey, SL; Fowler, JS; Gatley, SJ; Logan, J; MacGregor, RR; Volkow, ND; Wolf, AP | 1 |
| Lau, CE | 1 |
| Harbison, RD; James, RC; Munson, JW; Roberts, SM | 1 |
| Chamberlin, P; Flood, JG; Puopolo, PR | 1 |
| Katz, JL; Terry, P; Witkin, JM | 1 |
| Brogan, WC; Glamann, DB; Hillis, LD; Lange, RA | 1 |
| Browne, S; Moore, C; Negrusz, A; Tebbett, I | 1 |
| Harbison, RD; James, RC; Roberts, SM; Roth, L | 1 |
| Jeffcoat, AR; Perez-Reyes, M | 1 |
| Randall, T | 1 |
| Bradberry, CW; Elsworth, JD; Hearn, WL; Jatlow, P; Roth, RH; Taylor, JR | 1 |
| Balster, RL; Carroll, FI; Mansbach, R; Woodward, JJ | 1 |
| Bosron, WF; Christian, CD; Dean, RA; Sample, RH | 1 |
| Ciarleglio, A; Hearn, WL; Mash, DC; Rose, S; Wagner, J | 1 |
| Cofino, JC; Flynn, DD; Hearn, WL; Hime, GW; Mantero-Atienza, E; Mash, DC; Rose, S; Wetli, CV | 1 |
| Bradberry, CW; Elsworth, JD; Jatlow, P; Roth, RH; Russell, R; Taylor, JR; Winger, G | 1 |
| Barinaga, M | 1 |
| Allen, AC; Erzouki, HK; Goldberg, SR; Newman, AH; Schindler, CW | 1 |
| Bradberry, CW; Iyer, RN; Jatlow, PI; Nobiletti, JB | 1 |
| Meehan, SM; Schechter, MD | 3 |
| Baum, I; Erzouki, HK; Goldberg, SR; Schindler, CW | 1 |
| Chow, HH; Mayersohn, M; Sukbuntherng, J; Walters, A | 1 |
| Fowler, JS; Volkow, ND | 1 |
| Jatlow, PI; Kosten, TR; McCance, EF; Price, LH | 1 |
| Camí, J; de la Torre, R; Farré, M; González, ML; Ortuño, J; Segura, J | 1 |
| Jatlow, P | 2 |
| Bailey, DN | 12 |
| Dasgupta, A; Thompson, WC | 1 |
| Chiappelli, F; Frost, P; Kung, MA; Lee, P; Prieto, N; Villanueva, P | 1 |
| Flood, JG; Heith, AM; Laposata, M; Morse, CR; Tsujita, T; Volpacelli, SA | 1 |
| Cook, CE; Jeffcoat, AR; Myers, M; Perez-Reyes, M; Sihler, K | 1 |
| Chen, GJ; Pirozhkov, SV; Watson, RR | 1 |
| Masten, S; Phillips, DL; Shiverick, KT; Tebbett, IR | 1 |
| Kintz, P; Mangin, P | 1 |
| Balon, R | 1 |
| Carpentier, RG; Wang, J | 1 |
| Browne, S; Covert, R; Dusick, A; Moore, C; Negrusz, A; Tebbett, I | 1 |
| Perez-Reyes, M | 2 |
| Black, JE; Jatlow, PI; Kosten, TR; McCance-Katz, EF; McDougle, CJ; Price, LH | 1 |
| Bradberry, CW; Jatlow, PI; Nobiletti, JB | 1 |
| Meiergerd, SM; Schenk, JO | 1 |
| Clarkson, CW; Crumb, WJ; Xu, YQ | 1 |
| Leikin, JB; Lewis, DE; Moore, CM | 1 |
| Abraham, TL; Bosron, WF; Brzezinski, MR; Dean, RA; Stone, CL | 1 |
| Casale, JF; Moore, JM | 1 |
| Boggan, WO; Miller, SR; Patrick, KS; Salo, AL | 1 |
| Cone, EJ; Darwin, WD; Hillsgrove, M | 1 |
| Rose, JS | 1 |
| Covert, RF; Schreiber, MD; Tebbett, IR; Torgerson, LJ | 1 |
| Andollo, W; Hearn, WL; Hernandez, A | 1 |
| Costa, LG; Tan, XX | 1 |
| Schechter, MD | 2 |
| Dickson, PH; Lind, A; Makoid, M; Nipper, HC; Studts, P; Therkildsen, D | 1 |
| Grammas, P; Melchert, RB; Welder, AA | 1 |
| Boelsterli, UA; Göldlin, C; Wolf, A | 1 |
| Caughlin, LJ; O'Halloran, RL | 1 |
| Abukhalaf, IK; Abusada, GM; Alford, DD; Ansari, NA; Manno, BR; Manno, JE; Pramanik, AK; Vinzon-Bautista, I | 1 |
| Melchert, RB; Welder, AA | 1 |
| Morgan, JP; Qiu, Z | 1 |
| Downing, JW; Henderson, GI; Johnson, RF; King, TS; Schenken, RS; Schenker, S; Yang, Y | 1 |
| Bradberry, CW; Elsworth, JD; Jatlow, P; Murphy, B; Nobiletti, JB; Roth, RH | 1 |
| Colassis, T; Giroud, C; Ottinger, E; Rivier, L | 1 |
| Hashimoto, Y; Ishizu, H; Moriya, F | 1 |
| Brookoff, D; Campbell, EA; Fields, L; Rotondo, MF; Shaw, LM | 1 |
| Balraj, E; Earl, S; Henning, RJ; Lavins, E; Suttheimer, C; Wilson, LD | 1 |
| Konkol, RJ; Kron, JE; Olsen, GD | 1 |
| Fukui, Y; Hayase, T; Yamamoto, K; Yamamoto, Y | 1 |
| Kleven, MS; Koek, W; Prinssen, EP | 1 |
| Hashimoto, Y; Moriya, F | 2 |
| Henning, RJ; Wilson, LD | 1 |
| Bai, H; Islam, MN; Kuroki, H; Otsu, K; Tada, M; Terada, M; Wakasugi, C | 1 |
| Hayase, T; Yamamoto, K; Yamamoto, Y | 2 |
| Clauwaert, KM; De Leenheer, AP; Lambert, WE; Van Bocxlaer, JF | 3 |
| Laizure, SC; Lima, JJ; Parker, RB; Williams, CL | 1 |
| Hedaya, MA; Pan, WJ | 3 |
| Bradberry, CW; Elsworth, JD; Jatlow, P; McCance, EF; Roth, RH; Taylor, JR | 1 |
| LaBranche, GS; Laizure, SC; Lima, JJ; Mandrell, TD; Parker, RB; Williams, CL | 1 |
| Bertholf, RL; Phillips, DL; Tebbett, IR | 1 |
| Logan, BK; Smirnow, D | 1 |
| Elsworth, JD; Horger, BA; Jatlow, PI; Roth, RH; Taylor, JR | 1 |
| Dickey-White, HI; Kulics, AT; Perch, S; Schechter, MD; Signs, SA; Vanek, VW | 1 |
| Buss, T; Dickey-White, HI; Kulics, AT; Schechter, MD; Signs, SA; Vanek, VW | 1 |
| Alburges, ME; Crouch, DJ; Moody, DE; Rollins, DE; Spanbauer, AC | 1 |
| Cirimele, V; Kintz, P; Mangin, P; Sengler, C | 1 |
| Crayton, JW; Deakin, AG; Ivery, DM; O'Connor, FL; Reid, RW | 1 |
| Horowitz, JM; Torres, G | 3 |
| Horowitz, JM; Lee, S; Rivier, C; Torres, G | 1 |
| DiPirro, JM; Horowitz, JM; Kristal, MB; Torres, G | 1 |
| Horowitz, JM; Kristal, MB; Torres, G | 1 |
| Chen, WJ; West, JR | 1 |
| Boni, RL; Burdick, JD; Fochtman, FW | 1 |
| Andrews, P | 1 |
| Bosron, WF; Brzezinski, MR; Dean, RA; Zachman, FM; Zhang, J | 1 |
| Aguila-Mansilla, N; Barnea, A; Ho, RH; Little, BB | 1 |
| Camí, J; de la Torre, R; Farré, M; González, ML; Menoyo, E; Roset, PN; Terán, MT | 1 |
| Laizure, SC; Lima, JJ; Mandrell, TD; Parker, RB; Williams, CL | 1 |
| Bourland, JA; Martin, DK; Mayersohn, M | 1 |
| Etkind, SA; Fantegrossi, WE; Riley, AL | 1 |
| Artaud, F; Borrelli, E; Chéramy, A; Glowinski, J; Godeheu, G; L'hirondel, M; Saiardi, A | 1 |
| Clauwaert, KM; De Leenheer, AP; Esmans, EL; Lambert, WE; Lemière, F; Van Bocxlaer, JF; Van den Eeckhout, EG | 1 |
| Cami, J; de la Torre, R; Farré, M; González, ML; Segura, J | 1 |
| Baumann, MH; Horowitz, JM; Kristal, MB; Torres, G | 1 |
| Abdel-Rahman, MS; Figliomeni, ML | 1 |
| Carpentier, RG; Jain, AK | 1 |
| Bhatti, E; Devi, BG; Horowitz, JM; Torres, G | 1 |
| Cooper, TB; Morishima, HO; Whittington, RA; Zhang, Y | 1 |
| Cooper, TB; Iso, A; Morishima, HO; Whittington, RA | 1 |
| Laizure, SC; Parker, RB; Song, N | 1 |
| Kolodgie, FD; Mergner, WJ; Virmani, R; Wilson, PS | 1 |
| Riley, AL; Sobel, BF | 1 |
| Bradberry, CW; Jatlow, P; Lee, T | 1 |
| Altieri, I; Pacifici, R; Pellegrini, M; Pichini, S; Zuccaro, P | 1 |
| Darwin, D; Eldefrawi, M; Huestis, M; Nath, N; Wright, J | 1 |
| Bort, R; Castell, JV; Gómez-Lechón, MJ; Jover, R; Ponsoda, X | 1 |
| Bohnenkamp, M; Pragst, F; Spiegel, K; Sporkert, F | 1 |
| Danluck, DA; Ettenberg, A; Necessary, BD; Raven, MA | 1 |
| Chasin, AA; Mídio, AF | 1 |
| Hart, CL; Jatlow, P; McCance-Katz, EF; Sevarino, KA | 1 |
| Davis, GG; Embry, JH; Gruszecki, AC; Robinson, CA | 1 |
| Bourland, JA; Hatab, MM; Hayes, EF; Kelly, RC; Sweeney, SA | 1 |
| Aunis, D; Thiriet, N; Zwiller, J | 1 |
| Dorbandt, A; Garvey, L; Jeromin, J; Wilson, LD | 1 |
| Antonilli, L; Grassi, MC; Nencini, P; Suriano, C | 1 |
| Appel, SB; Brodie, MS; Bunney, EB | 1 |
| Antonilli, L; Linari, G; Nencini, P; Nucerito, V | 1 |
| Heine, A; Janda, KD; Larsen, NA; Wilson, IA; Wirsching, P; Zhou, B | 1 |
| Goldberg, SR; Schindler, CW; Zheng, JW | 1 |
| O'Leary, ME | 1 |
| Larson, DF; Liu, Y; Montes, S; Sepúlveda, RT; Watson, RR; Yu, Q; Zhang, D; Zhang, J | 1 |
| Ettenberg, A; Knackstedt, LA; Samimi, MM | 1 |
| Leccese, AP; Pennings, EJ; Wolff, FA | 1 |
| French, S; Wilson, LD | 1 |
| Charbit, B; Lepere, B | 1 |
| Gades, NM; Laizure, SC; Mandrell, T; Parker, RB | 1 |
| Everhart, ET; Harris, DS; Jones, RT; Mendelson, J | 1 |
| de Moraes Moreau, RL; de Toledo, FC; Silva, OA; Yonamine, M | 1 |
| Chahine, M; Digregorio, M; O'Leary, ME | 1 |
| Agulian, SK; Baldwin, RM; Bradberry, CW; Everill, B; Kocsis, JD; Tamagnan, GD; Tokuno, HA; Wilkes, S | 1 |
| Okorodudu, AO; Tacker, DH | 1 |
| Blanchard, D; Danger, Y; Devys, A; Folléa, G; Gadjou, C; Galons, H | 1 |
| Sable, HJ; Steinpreis, RE; White, SL | 1 |
| de Moraes Moreau, RL; Follador, MJ; Silva, OA; Yonamine, M | 1 |
| Cooper, GJ; Sheridan, RD; Tattersall, JE; Turner, SR | 1 |
| Bouchonnet, S; Cognard, E; Rudaz, S; Staub, C | 1 |
| Alvarez, I; Bermejo, AM; Fernández, P; López, P; Tabernero, MJ | 2 |
| Bermejo, AM; Fernández, P; Morales, L; Tabernero, MJ; Vázquez, C | 1 |
| Contreras, MT; de la Torre, R; González, M; González, S; Hernández, AF; Pla, A; Segura, J; Valverde, JL; Ventura, R | 1 |
| Saviano, AM; Yonamine, M | 1 |
| Herzog, NK; Okorodudu, AO; Tacker, DH | 1 |
| Antonilli, L; Cioce, AM; Giudici, FD; Grassi, MC; Nencini, P | 1 |
| Morini, L; Polettini, A; Politi, L; Stramesi, C; Zucchella, A | 1 |
| Lowenstein, W; Noble, F; Sanchez, M | 1 |
| Contreras, MT; de la Torre, R; González, M; González, S; Hernández, AF; Pla, A; Segura, J; Valverde, JL; Ventura, R; Vingut, A | 1 |
| Casale, JF | 1 |
| Cairns, T; Hill, V; Schaffer, M | 1 |
| Baker, J; Jatlow, P; McCance-Katz, EF; Pade, P; Ramakrishnan, V | 1 |
| Bermejo, AM; Carro, AM; Fernández, P; Lago, M; Lorenzo, RA; Tabernero, MJ | 2 |
| Coulter, C; Crompton, K; Moore, C | 1 |
| Hoelzle, C; Sachs, H; Scheufler, F; Thieme, D; Uhl, M | 1 |
| Bradberry, CW; Heitz, RP; Liu, S; Sampson, AR; Zhang, W | 1 |
| Favretto, D; Ferrara, SD; Frison, G; Seraglia, R; Traldi, P; Vogliardi, S | 1 |
| Jagerdeo, E; Lebeau, MA; Montgomery, MA; Sibum, M | 1 |
| Feng, LI; Hsieh, YZ; Jen, HP; Su, HL | 1 |
| Laizure, SC; Parker, RB | 2 |
| Balducci, C; Cecinato, A; Nervegna, G | 1 |
| Abela, GS; Bhadula, R; Opreanu, M; Pandya, K; Patel, MB; Shah, AJ; Thakur, RK | 1 |
| Jenkins, AJ; McGrath, KK | 1 |
| Harrington, PB; Lu, Y; O'Donnell, RM | 1 |
| Chasin, AA; da Costa, JL; Tavares, MF; Tonin, FG; Zanolli, LA | 1 |
| Bhatt, A; Farooq, MU; Patel, M | 1 |
| Cordero, R; Lee, S; Paterson, S | 1 |
| Cruz, A; de Castro, A; Jurado, C; Lendoiro, E; López-Rivadulla, M; Quevedo, A; Quintela, O | 1 |
| Civit, E; de la Torre, R; Falcón, M; Garcia-Algar, O; Joya, X; Luna, A; Pichini, S; Pujadas, M; Vall, O | 1 |
| Dasgupta, A; Fleming, SW; Garg, U | 1 |
| Gunn, J; Kriger, S; Terrell, AR | 1 |
| Calaycay, J; Moon, CH; Rushbrook, JI; Subramanian, RA; Sutijono, D; Wiener, SE; Zehtabchi, S | 1 |
| Gerra, G; Mandrioli, R; Mercolini, L; Raggi, MA | 1 |
| Bertol, E; Del Bravo, E; Furlanetto, S; Mari, F; Politi, L | 1 |
| Everhart, ET; Harris, DS; Herbst, ED; Jacob, P; Jones, RT; Mendelson, J | 1 |
| Grivet, C; Hopfgartner, G; Kraemer, T; Porta, T; Varesio, E | 1 |
| Brim, RL; Collins, GT; Narasimhan, D; Nichols, J; Noon, KR; Sunahara, RK; Woods, JH | 1 |
| Carro, AM; Fernández, P; Lorenzo, RA; Seoane, S; Tabernero, MJ; Vázquez, C | 1 |
| Álvarez, I; Bermejo, AM; Cataño, HC; Gil, F; Hernández, AF; López-Guarnido, O; Pla, A; Rodrigo, L; Tabernero, MJ | 1 |
| Huestis, MA; Ropero-Miller, JD; Stout, PR | 1 |
| Baker, DR; Kasprzyk-Hordern, B; Kvicalova, M; Očenášková, V | 1 |
| Alves De Melo, F; Kinsey, BM; Kosten, TR; Ladbury, JE; Orson, FM; Ramakrishnan, M | 1 |
| Drummer, OH; Pilgrim, JL; Woodford, N | 1 |
| Clare-Fasullo, G; Koren, G; Motok, I; Natekar, A; Rao, C; Walasek, P | 1 |
| Gianvecchio, VA; Leyton, V; Munoz, DR; Osselton, MD; Pounder, DJ; Rees, KA; Seulin, S; Yonamine, M | 1 |
| Arrey, T; Musshoff, F; Strupat, K | 1 |
| Bolgiano, DD; Hobbs, WE; López, JA; Moore, EE; Penkala, RA | 1 |
| Dulaurent, S; Gaulier, JM; Imbert, L; Lachâtre, G; Mercerolle, M; Morichon, J | 1 |
| Aroni, K; Fucci, N; Gambelunghe, C; Rossi, R | 1 |
| Gareri, J; Koren, G; Rao, C | 1 |
| Bison, F; Gerace, E; Petrarulo, M; Salomone, A; Vincenti, M | 1 |
| Hou, S; Zhan, CG; Zhan, M; Zheng, F; Zheng, X | 1 |
| Gonzalez, J; Hastedt, M; Pragst, F; Rubio, NC | 1 |
| Avershal, J; Bires, K; Rawls, SM; Seo, S; Tallarida, CS; Tallarida, RJ | 1 |
| Ihenetu, K; Na, S; Rosano, TG; Swift, TA; Wood, M | 1 |
| Alcalde, M; Brugada, R; Campuzano, O; Carbone, A; Cittadini, F; De Giovanni, N; Oliva, A; Partemi, S | 1 |
| Ball, WJ; Norman, AB; Tabet, MR; Wetzel, HN | 1 |
| Kirley, TL; Norman, AB | 1 |
| Hoff, BH; Johansen, JE; Karlsen, M; Liu, H | 1 |
| Feinstein, DL; Fettiplace, MR; Kowal, K; Lin, B; Lis, K; Pichurko, A; Ripper, R; Rubinstein, I; Schwartz, D; Weinberg, G | 1 |
| Bazuaye-Ekwuyasi, EA; Eltorky, MA; Kaphalia, BS; Ogunbileje, JO; Okorodudu, AO | 1 |
| Bermejo, AM; Bermejo-Barrera, P; Jesús Tabernero, M; Moreda-Piñeiro, A; Sánchez-González, J | 1 |
| Aroni, K; Bacci, M; Fucci, N; Gambelunghe, C; Gili, A; Pascali, V; Rossi, R | 1 |
| Belitsky, ÍT; Fruchtengarten, LV; Loddi, S; Rodrigues de Oliveira, CD; Silveira, Gde O; Yonamine, M; Zucoloto, AD | 1 |
| Bermejo-Barrera, P; Cabarcos, P; García-Carballal, S; Moreda-Piñeiro, A; Sánchez-González, J; Tabernero, MJ | 1 |
| Calcerrada, M; D'Elia, V; García Ruiz, C; Montalvo, G | 1 |
| Alves, RB; De Fátima, Â; Maia, AFDS; Martins, FT; Silva Neto, LD | 1 |
| Franz, T; Musshoff, F; Sachs, H; Schwarz, G; Skopp, G; Thieme, D | 1 |
| Bachler, S; Dittrich, PS; El Bakhi, S; Kernalléguen, A; Lafitte, D; Léonetti, G; Pélissier-Alicot, AL; Saint-Marcoux, F; Steinhoff, R; Vorspan, F; Zenobi, R | 1 |
| Gross, A; Hallak, H; Rosenstock, M; Shemesh-Darvish, L; Shinar, D | 1 |
| Andreuccetti, G; Berg, T; Gjerde, H; Leyton, V; Takitane, J; Vindenes, V | 1 |
| Jones, AW | 1 |
| Aranguren, M; Gorlelo, JC; Krumbiegel, F; Nagel, A; Poliansky, N; Pragst, F; Rubio, NC; Thurmann, D; Zytowski, E | 1 |
| Busardò, FP; Giorgetti, R; Gottardi, M; Pacifici, R; Pichini, S; Tini, A; Varì, MR; Volpe, AR | 1 |
| Antunes, MV; Bastiani, MF; Bulcão, R; da Silva, ACC; de Lima Feltraco Lizot, L; Hahn, RZ; Linden, R; Perassolo, MS | 1 |
| Antunes, MV; Bastiani, MF; da Silva, ACC; Hahn, RZ; Linden, R; Lizot, LLF; Maurer, TF; Perassolo, MS | 1 |
| Kirley, TL; Norman, AB; Wetzel, HN | 1 |
| Hartwig, S; Krumbiegel, F; Methling, M; Niebel, A; Pragst, F; Thurmann, D; Westendorf, L | 1 |
| Borges, KB; Dos Santos, NA; Filho, JFA; Lacerda, V; Pelição, FS; Romão, W | 1 |
| Brilla, CA; Kaljurand, M; Kulp, M; Leiman, K; Mazina-Šinkar, J; Saar-Reismaa, P; Vaher, M | 1 |
| Mandrioli, R; Mercolini, L; Protti, M | 1 |
| Gamero, J; Huertas, T; Jurado, C; Salguero, M; Soriano, T | 1 |
| de Oliveira, CDR; de Oliveira, TF; Eller, S; Fruchtengarten, LVG; Wagner, GA; Yonamine, M; Zucoloto, AD | 1 |
| Baum, MK; Bordi, R; Ehman, RL; Khalsa, JH; Lai, S; Mandler, RN; Schlatzer, D; Sékaly, RP; Sherman, KE; Tamargo, JA | 1 |
| Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S | 1 |
| Helander, A; Signell, P; Villén, T | 1 |
| Chen, X; Hou, S; Shang, L; Zhan, CG; Zhan, M; Zheng, F | 1 |
| Allen, MI; Johnson, BN; Nader, MA | 1 |
| Arbouche, N; de Lestrange, A; Kintz, P; Raul, JS | 1 |
10 review(s) available for cocaethylene and cocaine
| Article | Year |
|---|---|
Cardiovascular complications of cocaine abuse.
Topics: Adult; Cardiomyopathies; Cocaine; Coronary Disease; Ethanol; Heart Diseases; Humans; Myocardial Infarction; Neurotransmitter Uptake Inhibitors; Substance-Related Disorders | 1992 |
Cocaethylene: a current understanding of the active metabolite of cocaine and ethanol.
Topics: Alcoholism; Cocaine; Emergency Medicine; Humans; Neurotransmitter Uptake Inhibitors; Substance-Related Disorders | 1994 |
Cocaethylene: pharmacologic activity and clinical significance.
Topics: Animals; Cocaine; Ethanol; Humans; Neurotransmitter Uptake Inhibitors; Substance-Related Disorders | 1993 |
Cellular mechanisms of cocaine cardiotoxicity.
Topics: Animals; Cocaine; Exercise; Female; Fetus; Heart; Humans; Pregnancy | 1993 |
Cardiotoxic effects of cocaine and anabolic-androgenic steroids in the athlete.
Topics: Anabolic Agents; Cardiomyopathies; Cocaine; Doping in Sports; Heart Diseases; Humans; Myocardial Infarction; Neurotransmitter Uptake Inhibitors; Physical Endurance; Sports | 1993 |
Cocaethylene toxicity.
Topics: Alcoholism; Cocaine; Death, Sudden; Dopamine Uptake Inhibitors; Ethanol; Half-Life; Humans; Substance-Related Disorders | 1997 |
Effects of ethanol on cocaine metabolism and disposition in the rat.
Topics: Animals; Cocaine; Drug Interactions; Ethanol; Humans; Oxidation-Reduction; Rats; Substance-Related Disorders | 1997 |
Cocaine metabolism in humans after use of alcohol. Clinical and research implications.
Topics: Alcohol Drinking; Animals; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Humans; Metabolic Clearance Rate | 1998 |
Effects of concurrent use of alcohol and cocaine.
Topics: Alcohol-Related Disorders; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Health Surveys; Heart Rate; Humans; Prospective Studies; Retrospective Studies; Violence | 2002 |
Forensic Drug Profile: Cocaethylene.
Topics: Alcohol Drinking; Animals; Cocaine; Ethanol; Forensic Toxicology; Half-Life; Humans; Illicit Drugs; Lethal Dose 50; Toxicity Tests | 2019 |
15 trial(s) available for cocaethylene and cocaine
| Article | Year |
|---|---|
Recurrent coronary vasoconstriction caused by intranasal cocaine: possible role for metabolites.
Topics: Administration, Intranasal; Adult; Aged; Cineangiography; Cocaine; Coronary Angiography; Coronary Vessels; Double-Blind Method; Female; Humans; Male; Middle Aged; Random Allocation; Recurrence; Vasoconstriction | 1992 |
Ethanol/cocaine interaction: cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects.
Topics: Alcoholic Intoxication; Cardiovascular System; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Humans; Male; Reference Values; Single-Blind Method; Substance-Related Disorders | 1992 |
Cocaethylene: pharmacology, physiology and behavioral effects in humans.
Topics: Behavior; Blood Pressure; Cocaine; Dopamine Uptake Inhibitors; Double-Blind Method; Heart Rate; Humans; Placebos | 1995 |
Determination of cocaine and its metabolites in human urine by gas chromatography/mass spectrometry after simultaneous use of cocaine and ethanol.
Topics: Adult; Alcohol Drinking; Biotransformation; Cocaine; Dopamine Uptake Inhibitors; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Male; Solutions; Substance-Related Disorders | 1995 |
Comparison in humans of the potency and pharmacokinetics of intravenously injected cocaethylene and cocaine.
Topics: Adult; Cocaine; Cross-Over Studies; Dopamine Uptake Inhibitors; Euphoria; Half-Life; Heart Rate; Hemodynamics; Humans; Injections, Intravenous; Male; Single-Blind Method | 1994 |
Subjective and cardiovascular effects of cocaethylene in humans.
Topics: Adult; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Humans; Injections, Intravenous; Male; Single-Blind Method | 1993 |
Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene.
Topics: Adult; Affect; Behavior; Blood Pressure; Cocaine; Dopamine Uptake Inhibitors; Double-Blind Method; Drug Interactions; Ethanol; Euphoria; Half-Life; Heart Rate; Humans; Male | 1993 |
The order of drug administration: its effects on the interaction between cocaine and ethanol.
Topics: Administration, Inhalation; Blood Pressure; Cocaine; Drug Administration Schedule; Drug Interactions; Ethanol; Heart Rate; Humans; Male; Reference Values | 1994 |
Cocaine and alcohol interactions in humans: neuroendocrine effects and cocaethylene metabolism.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Cocaine; Dopamine; Drug Synergism; Ethanol; Heart Rate; Humans; Hydrocortisone; Male; Prolactin | 1997 |
Quinidine inhibition of cocaethylene degradation in human serum in vitro: a preliminary study.
Topics: Anti-Arrhythmia Agents; Cholinesterases; Cocaine; Dopamine Uptake Inhibitors; Humans; Hydrolysis; Male; Quinidine | 1999 |
Comparison of intravenous cocaethylene and cocaine in humans.
Topics: Adult; Blood Pressure; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Double-Blind Method; Female; Heart Rate; Humans; Injections, Intravenous; Male; Vasoconstrictor Agents | 2000 |
The pharmacology of cocaethylene in humans following cocaine and ethanol administration.
Topics: Adult; Blood Pressure; Chromatography; Cocaine; Cross-Over Studies; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Ethanol; Female; Heart Rate; Humans; Male; Metabolic Clearance Rate | 2003 |
Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: a pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Disulfiram; Humans; Naltrexone; Narcotic Antagonists; Patient Compliance; Pilot Projects; Time Factors; Treatment Outcome | 2007 |
Acute cocaine responses following cocaethylene infusion.
Topics: Adult; Behavior, Addictive; Blood Pressure; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Heart Rate; Hospitalization; Humans; Infusions, Intravenous; Male; Placebos; Treatment Outcome | 2007 |
Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, drug-user populations and surface-contaminated specimens.
Topics: Adolescent; Adult; Biotransformation; Cocaine; Environmental Exposure; Female; Forensic Toxicology; Guidelines as Topic; Hair; Humans; Illicit Drugs; Male; Middle Aged; Psychotropic Drugs; Substance Abuse Detection; Surface Properties; Tissue Distribution; United States; Young Adult | 2012 |
240 other study(ies) available for cocaethylene and cocaine
| Article | Year |
|---|---|
Effects of cocaine and ethylcocaine on schedule-controlled responding in rats.
Topics: Anesthetics, Local; Animals; Cocaine; Conditioning, Operant; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 1992 |
Effects of ethanol on cocaine metabolism: formation of cocaethylene and norcocaethylene.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Cocaine; Ethanol; Injections, Intraperitoneal; Liver; Male; Rats; Rats, Wistar; Time Factors | 1992 |
Gas chromatographic detection of cocaine and cocaethylene in hair of mice chronically injected with cocaine or cocaethylene and fed ethanol.
Topics: Administration, Oral; Animals; Chromatography, Gas; Cocaine; Drug Administration Schedule; Ethanol; Gas Chromatography-Mass Spectrometry; Hair; Injections, Intraperitoneal; Male; Mice; Neurotransmitter Uptake Inhibitors | 1992 |
Comparative PET studies of the kinetics and distribution of cocaine and cocaethylene in baboon brain.
Topics: Animals; Brain; Cocaine; Female; Kinetics; Papio; Time Factors; Tissue Distribution; Tomography, Emission-Computed | 1992 |
Determination of cocaethylene, cocaine and their metabolites in rat serum microsamples by high-performance liquid chromatography, and its application to pharmacokinetic studies in rodents.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cocaine; Ethanol; Injections, Intraperitoneal; Male; Neurotransmitter Uptake Inhibitors; Rats | 1992 |
An assay for cocaethylene and other cocaine metabolites in liver using high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Liver; Male; Mice; Mice, Inbred ICR | 1992 |
Detection and confirmation of cocaine and cocaethylene in serum emergency toxicology specimens.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Cocaine; Emergency Medical Services; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet; Time Factors; Toxicology | 1992 |
Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl-ester (cocaethylene).
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Drug Synergism; Ethanol; Male; Mice; Motor Activity; Neurotransmitter Uptake Inhibitors; Rats; Rats, Inbred Strains; Saimiri | 1992 |
Determination of cocaine and its metabolites in brain tissue using high-flow solid-phase extraction columns and high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Female; Rabbits; Reproducibility of Results | 1992 |
Cocaethylene hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Cocaine; Diazinon; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Necrosis; Phenobarbital | 1992 |
Cocaine, alcohol mix in body to form even longer lasting, more lethal drug.
Topics: Cocaine; Death, Sudden, Cardiac; Ethanol; Humans; Liver | 1992 |
Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Brain Chemistry; Cocaine; Dopamine; Ethanol; Humans; In Vitro Techniques; Motor Activity; Rats | 1990 |
Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies.
Topics: Animals; Biological Transport, Active; Cocaine; Corpus Striatum; Discrimination, Psychological; Dopamine; Male; Rats; Rats, Inbred Strains | 1991 |
Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine.
Topics: Carboxylic Ester Hydrolases; Chromatography, Gel; Cocaine; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Liver; Molecular Structure; Molecular Weight | 1991 |
Cocaethylene is more potent than cocaine in mediating lethality.
Topics: Animals; Cocaine; Female; Male; Mice; Motor Activity; Stereotyped Behavior | 1991 |
Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter.
Topics: Adult; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Esterification; Ethanol; Female; Humans; Liver; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins | 1991 |
Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Macaca mulatta; Motor Activity; Nucleus Accumbens; Piperazines; Rats; Receptors, Dopamine; Self Administration; Synaptosomes | 1991 |
Miami vice metabolite.
Topics: Alcoholic Intoxication; Cocaine; Drug Synergism; Humans; Substance-Related Disorders | 1990 |
Effects of cocaine, cocaine metabolites and cocaine pyrolysis products on the hindbrain cardiac and respiratory centers of the rabbit.
Topics: Animals; Blood Pressure; Cardiovascular Agents; Cocaine; Female; Heart Rate; Injections, Intra-Arterial; Male; Rabbits; Respiration; Respiratory System Agents; Rhombencephalon | 1995 |
Cocaine and cocaethylene: effects on extracellular dopamine in the primate.
Topics: Animals; Caudate Nucleus; Chlorocebus aethiops; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Microdialysis; Time Factors | 1995 |
The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.
Topics: Animals; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Lethal Dose 50; Male; Mice; Sex Characteristics | 1995 |
Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats.
Topics: Animals; Cocaine; Electrocardiography; Electrophysiology; Hemodynamics; Infusions, Intravenous; Male; Rats; Structure-Activity Relationship | 1993 |
Quantitative determination of cocaine, cocaethylene (ethylcocaine), and metabolites in plasma and urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Kinetics; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Brain-imaging studies of the combined use of cocaine and alcohol and of the pharmacokinetics of cocaethylene.
Topics: Adult; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Ethanol; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Papio; Tissue Distribution; Tomography, Emission-Computed | 1994 |
Cocaethylene. What is it?
Topics: Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Ethanol; Humans | 1995 |
Cocaine and cocaethylene binding in human serum.
Topics: Chromatography, High Pressure Liquid; Cocaine; Dialysis; Humans; Orosomucoid; Protein Binding; Serum Albumin | 1995 |
Confirmation and quantitation of cocaine, benzoylecgonine, ecgonine methyl ester, and cocaethylene by gas chromatography/mass spectrometry. Use of microwave irradiation for rapid preparation of trimethylsilyl and T-butyldimethylsilyl derivatives.
Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Microwaves; Trimethylsilyl Compounds | 1995 |
Immunotoxicity of cocaethylene.
Topics: Cells, Cultured; Cocaine; Dipeptidyl Peptidase 4; Humans; Immune System; Interleukin-2; Lymphocyte Activation; T-Lymphocytes | 1995 |
Fatty acid ethyl ester synthase catalyzes the esterification of ethanol to cocaine.
Topics: Acyltransferases; Cocaine; Ethanol; Fatty Acids; Humans; In Vitro Techniques; Tissue Distribution | 1995 |
Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Ethanol; Female; Lethal Dose 50; Male; Mice | 1995 |
Ethanol enhances immunosuppression induced by cocaine.
Topics: Alcoholism; Animals; Cocaine; Drug Synergism; Ethanol; Immune Tolerance; Interferon-gamma; Interleukin-2; Mice; Mice, Inbred C57BL; Spleen; Substance-Related Disorders; Tumor Necrosis Factor-alpha | 1993 |
Stimulatory effects of cocaine and its metabolites on IM-9 human B-lymphoblastoid cells.
Topics: B-Lymphocytes; Cell Line; Chromatography, High Pressure Liquid; Cocaine; Drug Stability; Humans; Lymphocyte Activation; Tetradecanoylphorbol Acetate | 1995 |
Simultaneous determination of opiates, cocaine and major metabolites of cocaine in human hair by gas chromotography/mass spectrometry (GC/MS).
Topics: Adolescent; Adult; Calibration; Cocaine; Dopamine Uptake Inhibitors; Drug Overdose; Ethylmorphine; Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hair; Heroin; Humans; Male; Morphine; Morphine Derivatives; Narcotics; Reproducibility of Results | 1995 |
Fluoxetine for cocaine dependence in methadone maintenance.
Topics: Alcoholism; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Fluoxetine; Heroin Dependence; Humans; Methadone; Substance Abuse Detection; Substance-Related Disorders | 1994 |
Electrophysiologic in-vitro effects of cocaine and its metabolites.
Topics: Action Potentials; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; Membrane Potentials; Papillary Muscles; Rats; Rats, Sprague-Dawley; Sinoatrial Node | 1994 |
Detection of cocaine, norcocaine, and cocaethylene in the meconium of premature neonates.
Topics: Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Premature; Male; Meconium; Pregnancy; Pregnancy Complications; Prospective Studies; Substance Abuse Detection; Urine | 1994 |
Differences in bioavailability between cocaine and cocaethylene and their implications for drug-reward studies.
Topics: Animals; Biological Availability; Cocaine; Dopamine Uptake Inhibitors; Injections, Intraperitoneal; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Reward | 1994 |
Kinetic evaluation of the commonality between the site(s) of action of cocaine and some other structurally similar and dissimilar inhibitors of the striatal transporter for dopamine.
Topics: Animals; Benztropine; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Male; Mazindol; Models, Biological; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Rats; Rats, Sprague-Dawley | 1994 |
Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels.
Topics: Animals; Cocaine; Drug Interactions; Ethanol; Guinea Pigs; Heart; In Vitro Techniques; Sodium Channels | 1994 |
Cocaethylene in meconium specimens.
Topics: Cocaine; Cross Reactions; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Meconium | 1994 |
Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine.
Topics: Amino Acid Sequence; Carboxylic Ester Hydrolases; Cocaine; Ethanol; Humans; Liver; Molecular Sequence Data; Peptide Fragments; Trypsin | 1994 |
An in-depth analysis of pharmaceutical cocaine: cocaethylene and other impurities.
Topics: Chromatography, Gas; Cocaine; Dopamine Uptake Inhibitors; Drug Contamination | 1994 |
Determination of plasma cocaine and ethylcocaine (cocaethylene) in mice using gas chromatography-mass spectrometry and deuterated internal standards.
Topics: Animals; Cocaine; Deuterium; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Mice; Mice, Inbred C57BL; Reference Standards | 1994 |
Simultaneous measurement of cocaine, cocaethylene, their metabolites, and "crack" pyrolysis products by gas chromatography-mass spectrometry.
Topics: Administration, Intranasal; Body Fluids; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Injections, Intravenous; Kinetics; Male; Saliva; Sensitivity and Specificity; Smoking; Substance-Related Disorders | 1994 |
Hemodynamic and cerebral blood flow effects of cocaine, cocaethylene and benzoylecgonine in conscious and anesthetized fetal lambs.
Topics: Amniotic Fluid; Anesthesia; Animals; Brain; Cerebrovascular Circulation; Cocaine; Consciousness; Female; Fetus; Hemodynamics; Hypertension; Neurotransmitter Uptake Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Sheep; Transducers; Ultrasonics; Uterus; Vascular Resistance | 1994 |
Analysis of cocaine and metabolites in brain using solid phase extraction and full-scanning gas chromatography/ion trap mass spectrometry.
Topics: Brain Chemistry; Cause of Death; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Neurotransmitter Uptake Inhibitors | 1994 |
Inhibition of muscarinic receptor-stimulated phosphoinositide metabolism by cocaine, norcocaine and cocaethylene in rat brain.
Topics: Animals; Brain Chemistry; Carbachol; Cerebral Cortex; Cocaine; Female; Male; Muscarinic Antagonists; Neurotransmitter Uptake Inhibitors; Parasympatholytics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Sprague-Dawley | 1994 |
Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.
Topics: Animals; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Rats; Rats, Inbred Strains | 1994 |
The routine analysis of breast milk for drugs of abuse in a clinical toxicology laboratory.
Topics: Adult; Cocaine; Codeine; Ethanol; Female; Humans; Illicit Drugs; Infant, Newborn; Milk, Human; Neurotransmitter Uptake Inhibitors; Nicotine; Oxycodone; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Substance Abuse Detection; Substance-Related Disorders | 1994 |
Thin-layer chromatographic detection of cocaethylene in human urine.
Topics: Adult; Chromatography, Thin Layer; Cocaine; Female; Humans; Male; Sensitivity and Specificity | 1994 |
Oxygen free radical production mediated by cocaine and its ethanol-derived metabolite, cocaethylene, in rat hepatocytes.
Topics: Animals; Cells, Cultured; Cocaine; Drug Stability; Ethanol; Free Radicals; L-Lactate Dehydrogenase; Liver; Luminescent Measurements; Luminol; Male; Microsomes, Liver; Oxidation-Reduction; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 1993 |
An accidental death related to cocaine, cocaethylene, and caffeine.
Topics: Adult; Arrhythmias, Cardiac; Caffeine; Cocaine; Ethanol; Fatal Outcome; Female; Humans; Substance-Related Disorders | 1993 |
Solid-phase extraction and GC/MS quantitation of cocaine, ecgonine methyl ester, benzoylecgonine, and cocaethylene from meconium, whole blood, and plasma.
Topics: Cocaine; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Meconium; Pregnancy; Prenatal Exposure Delayed Effects; Time Factors | 1993 |
Differential effects of cocaine and cocaethylene on intracellular Ca2+ and myocardial contraction in cardiac myocytes.
Topics: Animals; Calcium; Cocaine; Ferrets; Fluorescent Dyes; Heart; In Vitro Techniques; Indoles; Myocardial Contraction; Myocardium; Neurotransmitter Uptake Inhibitors; Norepinephrine | 1993 |
Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit.
Topics: Adult; Cocaine; Emergency Service, Hospital; Ethanol; Female; Humans; Male; Osmolar Concentration; Trauma Centers | 1993 |
The transfer of cocaine and its metabolites across the term human placenta.
Topics: Biological Transport; Cocaine; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Placenta; Pregnancy | 1993 |
Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin.
Topics: Animals; Brain; Cocaine; Corpus Striatum; Dialysis; Dopamine; Injections, Intravenous; Nucleus Accumbens; Peritoneum; Rats; Serotonin | 1993 |
[Cocaine and alcohol: an explosive cocktail!].
Topics: Cocaine; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Neurotransmitter Uptake Inhibitors; Substance-Related Disorders | 1993 |
Effects of cocaine administration route on the formation of cocaethylene in drinkers: an experiment using rats.
Topics: Alcoholic Intoxication; Animals; Cocaine; Forensic Medicine; Humans; Male; Rats; Rats, Wistar; Reproducibility of Results; Substance Abuse Detection; Time Factors; Tissue Distribution | 1995 |
Coacaethylene levels in patients who test positive for cocaine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cocaine; Dopamine Uptake Inhibitors; Emergency Service, Hospital; Ethanol; Female; Humans; Male; Middle Aged; Substance-Related Disorders | 1996 |
Cocaethylene causes dose-dependent reductions in cardiac function in anesthetized dogs.
Topics: Animals; Arrhythmias, Cardiac; Cocaine; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart; Heart Rate; Myocardial Contraction; Oxygen Consumption | 1995 |
In vivo pharmacokinetics and in vitro production of cocaethylene in pregnant guinea pigs.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Ethanol; Female; Mice; Microsomes, Liver; Pregnancy | 1996 |
Role of brain cocaethylene levels in combined cocaine-ethanol lethality in mice.
Topics: Animals; Brain Chemistry; Cocaine; Ethanol; Male; Mice; Mice, Inbred ICR | 1996 |
Cocaine and cocaethylene binding to human tissues: a preliminary study.
Topics: Adult; Blood Proteins; Chromatography, High Pressure Liquid; Cocaine; Dialysis; Dopamine Uptake Inhibitors; Female; Humans; In Vitro Techniques; Male; Pregnancy; Protein Binding; Solutions | 1996 |
Repeated administration of cocaethylene induces context-dependent sensitization to its locomotor effects.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Locomotion; Male; Mice; Motor Activity | 1996 |
Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine.
Topics: Animals; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Drug Interactions; Epilepsy, Tonic-Clonic; Female; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Seizures; Status Epilepticus | 1996 |
Postmortem stability of cocaine and cocaethylene in blood and tissues of humans and rabbits.
Topics: Animals; Brain Chemistry; Cocaine; Drug Stability; Humans; In Vitro Techniques; Liver; Male; Muscle, Skeletal; Postmortem Changes; Rabbits; Reproducibility of Results; Substance Abuse Detection | 1996 |
Cocaethylene is as cardiotoxic as cocaine but is less toxic than cocaine plus ethanol.
Topics: Animals; Blood Pressure; Cocaine; Dogs; Drug Interactions; Ethanol; Heart; Heart Rate; Humans; Myocardium; Oxygen; Pulmonary Artery; Stroke Volume; Time Factors; Ventricular Function, Left | 1996 |
Direct cardiotoxic effects of cocaine and cocaethylene on isolated cardiomyocytes.
Topics: Animals; Calcium; Calcium Channels; Cardiotonic Agents; Cocaine; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium; Rats; Rats, Wistar; Sarcoplasmic Reticulum | 1996 |
Protective effects of buprenorphine against amplified cocaine and ethanol lethality in mice: role of cocaethylene.
Topics: Animals; Brain Chemistry; Buprenorphine; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Ethanol; Liver; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Narcotics | 1996 |
Analysis of cocaine, benzoylecgonine, and cocaethylene in urine by HPLC with diode array detection.
Topics: Chromatography, High Pressure Liquid; Cocaine; Humans; Indicators and Reagents; Narcotics; Spectrophotometry, Ultraviolet; Substance Abuse Detection | 1996 |
Quantitation of cocaine and cocaethylene in canine serum by high-performance liquid chromatography.
Topics: Acetonitriles; Animals; Buffers; Chromatography, High Pressure Liquid; Cocaine; Dogs; Hydrogen-Ion Concentration; Phosphates | 1996 |
Cocaine and alcohol interactions in naive and alcohol-pretreated rats.
Topics: Alcoholism; Animals; Cocaine; Cross-Over Studies; Drug Interactions; Ethanol; Male; Rats; Rats, Wistar; Substance-Related Disorders | 1996 |
Alcohol plus cocaine: the whole is more than the sum of its parts.
Topics: Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Ethanol; Humans; Narcotics; Opioid-Related Disorders; Substance Abuse Detection | 1996 |
Effects of ethanol and cocaethylene on cocaine pharmacokinetics in conscious dogs.
Topics: Animals; Cocaine; Dogs; Drug Interactions; Ethanol; Female; Male | 1996 |
Comparison of HPLC and GC-MS for measurement cocaine and metabolites in human urine.
Topics: Chromatography, High Pressure Liquid; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Urinalysis | 1996 |
Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS.
Topics: Alkylation; Amines; Biotransformation; Carboxylic Acids; Cocaine; Esterification; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Reference Standards; Solvents; Structure-Activity Relationship | 1996 |
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Locomotion; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 1996 |
The formation of cocaethylene and clinical presentation of ED patients testing positive for the use of cocaine and ethanol.
Topics: Adult; Alcohol Drinking; Cocaine; Cross-Sectional Studies; Dopamine Uptake Inhibitors; Emergencies; Female; Humans; Male; Prospective Studies; Substance-Related Disorders | 1996 |
Concurrent use of cocaine and alcohol by patients treated in the emergency department.
Topics: Adult; Alcoholic Intoxication; Cocaine; Cohort Studies; Demography; Dopamine Uptake Inhibitors; Drug Interactions; Ethanol; Female; Hemodynamics; Humans; Male; Opioid-Related Disorders; Retrospective Studies; Wounds and Injuries | 1996 |
Analysis of cocaine and its metabolites from biological specimens using solid-phase extraction and positive ion chemical ionization mass spectrometry.
Topics: Calibration; Chromatography; Cocaine; Dopamine Uptake Inhibitors; Humans; Mass Spectrometry; Narcotics; Reference Standards; Reproducibility of Results; Tissue Distribution | 1995 |
Testing human hair and urine for anhydroecgonine methyl ester, a pyrolysis product of cocaine.
Topics: Cocaine; Dopamine Uptake Inhibitors; Gas Chromatography-Mass Spectrometry; Hair; Humans; Illicit Drugs; Indicators and Reagents; Trimethylsilyl Compounds | 1995 |
Population-based prevalence of perinatal exposure to cocaine--Georgia, 1994.
Topics: Blood Chemical Analysis; Cocaine; Female; Georgia; Humans; Infant, Newborn; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Prevalence; Substance Abuse Detection; Substance-Related Disorders | 1996 |
The effect of postmortem interval on the concentrations of cocaine and cocaethylene in blood and tissues: an experiment using rats.
Topics: Administration, Oral; Animals; Brain Chemistry; Cocaine; Ethanol; Forensic Medicine; Injections, Intramuscular; Liver; Male; Muscles; Rats; Rats, Wistar; Time Factors | 1996 |
Cocaine and metabolites in human graying hair: pigmentary relationship.
Topics: Adult; Cocaine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Middle Aged; Narcotics; Pigments, Biological; Substance-Related Disorders | 1996 |
Combined effects of ethanol and cocaine on FOS-like protein and cocaethylene biosynthesis in the rat.
Topics: Animals; Brain; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Ethanol; Immunohistochemistry; Male; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1996 |
Comprehensive review of cocaethylene and cocaine concentrations in patients.
Topics: Adult; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Ethanol; Female; Humans; Male; Middle Aged | 1996 |
Cocaethylene stimulates the secretion of ACTH and corticosterone and the transcriptional activation of hypothalamic NGFI-B.
Topics: Adrenocorticotropic Hormone; Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Hypothalamus; In Situ Hybridization; Male; Nerve Growth Factors; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1996 |
Discrimination of cocaethylene in rats trained to discriminate between its components.
Topics: Animals; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Male; Rats | 1997 |
Dopaminergic and glutamatergic mechanisms mediate the induction of FOS-like protein by cocaethylene.
Topics: Analgesics; Animals; Benzazepines; Brain; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Female; Glutamic Acid; Kinetics; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
Differential behavioral responses to cocaethylene of Long-Evans and Sprague-Dawley rats: role of serotonin.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Female; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Serotonin | 1997 |
Effect of alcohol coadministration on the plasma and brain concentrations of cocaine in rats.
Topics: Animals; Brain Chemistry; Cocaine; Drug Synergism; Ethanol; Extracellular Space; Male; Rats; Rats, Wistar | 1997 |
Cocaethylene exposure during the brain growth spurt period: brain growth restrictions and neurochemistry studies.
Topics: Animals; Biogenic Monoamines; Body Weight; Brain; Brain Chemistry; Brain Stem; Cerebellum; Cerebral Cortex; Cocaine; Dopamine Uptake Inhibitors; Female; Male; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 1997 |
Quantitation of cocaine and cocaethylene in small volumes of rat whole blood using gas chromatography-mass spectrometry.
Topics: Animals; Cocaine; Drug Interactions; Ethanol; Gas Chromatography-Mass Spectrometry; Rats; Rats, Wistar; Sensitivity and Specificity | 1997 |
Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection.
Topics: Chromatography, Liquid; Cocaine; Humans; Molecular Structure | 1997 |
Effect of drugs and cocaine metabolites on cocaine and cocaethylene binding to human serum in vitro.
Topics: Amphetamine; Analgesics, Opioid; Blood Proteins; Central Nervous System Stimulants; Cocaine; Codeine; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Methamphetamine; Morphine; Narcotics | 1997 |
Cocaethylene: a novel cocaine homolog.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cocaine; Dopamine Uptake Inhibitors; Humans | 1997 |
Differential potencies of cocaine and its metabolites, cocaethylene and benzoylecgonine, in suppressing the functional expression of somatostatin and neuropeptide Y producing neurons in cultures of fetal cortical cells.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Cocaine; Female; Fetus; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Somatostatin | 1997 |
Cocaine and cocaethylene binding to human placenta in vitro.
Topics: Binding Sites; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Female; Humans; In Vitro Techniques; Least-Squares Analysis; Placenta; Pregnancy | 1997 |
Evaluation of dose-dependent pharmacokinetics of cocaethylene and cocaine in conscious dogs.
Topics: Animals; Cocaine; Dogs; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Metabolic Clearance Rate | 1998 |
In vitro transesterification of cocaethylene (ethylcocaine) in the presence of ethanol. esterase-mediated ethyl ester exchange esterase-mediated ethyl ester exchange.
Topics: Animals; Cocaine; Enzyme Inhibitors; Esterases; Ethanol; Kinetics; Liver; Male; Nitrophenols; Physostigmine; Rats; Rats, Sprague-Dawley; Tritium | 1998 |
Cocaine and alcohol synergism in taste aversion learning.
Topics: Animals; Avoidance Learning; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Ethanol; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Narcotics; Rats | 1998 |
Activating properties of cocaine and cocaethylene in a behavioral preparation of Drosophila melanogaster.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Drosophila melanogaster; Microscopy, Electron, Scanning; Motor Activity; Nervous System; Receptors, Dopamine D1; Stereotyped Behavior; Stimulation, Chemical | 1998 |
Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice.
Topics: 4-Aminopyridine; Amphetamine; Animals; Apomorphine; Autoreceptors; Benzopyrans; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoresceins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Inhibition; Oxazines; Potassium Chloride; Presynaptic Terminals; Quinpirole; Receptors, Dopamine D2; Synaptosomes; Tritium | 1998 |
Narrow-bore HPLC in combination with fluorescence and electrospray mass spectrometric detection for the analysis of cocaine and metabolites in human hair.
Topics: Chromatography, High Pressure Liquid; Cocaine; Hair; Humans; Mass Spectrometry; Reproducibility of Results; Spectrometry, Fluorescence; Substance-Related Disorders | 1998 |
Cocaine and cocaethylene binding to human liver.
Topics: Adult; Aged; Anesthetics, Local; Cocaine; Dopamine Uptake Inhibitors; Female; Humans; Liver; Male; Middle Aged; Placenta | 1998 |
Effects of cocaethylene on dopamine and serotonin synthesis in Long-Evans and Sprague-Dawley brains.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Levodopa; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Serotonin | 1998 |
Cocaine and cocaethylene binding to human milk.
Topics: Cocaine; Dopamine Uptake Inhibitors; Humans; Hydrogen-Ion Concentration; Kinetics; Milk, Human | 1998 |
Ethanol does not increase the hepatotoxicity of cocaine in primary rat hepatocyte culture.
Topics: Animals; Cells, Cultured; Cocaine; Drug Synergism; Ethanol; L-Lactate Dehydrogenase; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1998 |
Cardiac electrophysiological actions and interactions of ethanol, cocaine, and the metabolite ethylcocaine.
Topics: Action Potentials; Animals; Cocaine; Drug Interactions; Electrophysiology; Ethanol; In Vitro Techniques; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Sinoatrial Block; Sinoatrial Node | 1998 |
Behavior and drug measurements in Long-Evans and Sprague-Dawley rats after ethanol-cocaine exposure.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Cocaine; Drug Interactions; Ethanol; Liver; Male; Rats; Rats, Long-Evans; Rats, Sprague-Dawley | 1999 |
Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects.
Topics: Algorithms; Animals; Area Under Curve; Biotransformation; Blood Pressure; Brain Chemistry; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Ethanol; Heart Rate; Injections, Intravenous; Male; Rats; Rats, Wistar | 1999 |
Cocaethylene synthesis in Drosophila.
Topics: Animals; Biotransformation; Cocaine; Dopamine Uptake Inhibitors; Drosophila melanogaster; Ethanol; Female; Humans; Male; Models, Chemical; Species Specificity | 1999 |
The disposition of cocaethylene in rat maternal, placental, and fetal compartments.
Topics: Amnion; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Fetus; Kinetics; Liver; Maternal-Fetal Exchange; Myocardium; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley | 1999 |
The comparative toxicity of cocaine and its metabolites in conscious rats.
Topics: Animals; Blood Pressure; Cocaine; Female; Heart Rate; Rats; Rats, Sprague-Dawley | 1999 |
Cocaethylene formation in rat, dog, and human hepatic microsomes.
Topics: Animals; Cocaine; Dogs; Dose-Response Relationship, Drug; Ethanol; Humans; Kinetics; Microsomes, Liver; Rats; Rats, Wistar | 1999 |
Cocaine-induced increase in the permeability function of human vascular endothelial cell monolayers.
Topics: Actins; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cocaine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electric Impedance; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Humans; Lipoproteins, LDL; Peroxidase; Umbilical Veins; Vasoconstrictor Agents | 1999 |
The interaction of cocaethylene and cocaine and of cocaethylene and alcohol on schedule-controlled responding in rats.
Topics: Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Rats; Rats, Long-Evans | 1999 |
Role of cocaethylene in toxic symptoms due to repeated subcutaneous cocaine administration modified by oral doses of ethanol.
Topics: Administration, Oral; Animals; Body Weight; Brain; Cocaine; Drug Interactions; Epilepsy, Tonic-Clonic; Ethanol; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Motor Activity; Respiration; Respiration Disorders; Survival Rate | 1999 |
Rapid induction of behavioral and neurochemical tolerance to cocaethylene, a model compound for agonist therapy of cocaine dependence.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Drug Tolerance; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1999 |
Determination of opiates and cocaine in hair as trimethylsilyl derivatives using gas chromatography-tandem mass spectrometry.
Topics: Cocaine; Codeine; Gas Chromatography-Mass Spectrometry; Hair; Heroin; Humans; Indicators and Reagents; Morphine; Morphine Derivatives; Narcotics; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection; Substance-Related Disorders; Trimethylsilyl Compounds | 1999 |
A rapid reusable fiber optic biosensor for detecting cocaine metabolites in urine.
Topics: Antibodies, Monoclonal; Biosensing Techniques; Cocaine; Dopamine Uptake Inhibitors; Fiber Optic Technology; Fluorescence Polarization Immunoassay; Humans; Narcotics; Optical Fibers; Protein Binding; Reproducibility of Results; Sensitivity and Specificity; Urine | 1999 |
Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH.
Topics: Aged; Cell Survival; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Ethanol; Female; Glutathione Transferase; Humans; Liver; Male; Middle Aged; Oxidative Stress | 1999 |
Are there possibilities for the detection of chronically elevated alcohol consumption by hair analysis? A report about the state of investigation.
Topics: Acetaldehyde; Alcohol Drinking; Biomarkers; Carbolines; Cocaine; Ethanol; Fatty Acids; Gas Chromatography-Mass Spectrometry; Glucuronates; Glycerophospholipids; Hair; Humans; Isoquinolines; Substance Abuse Detection | 2000 |
Comparison of the reinforcing and anxiogenic effects of intravenous cocaine and cocaethylene.
Topics: Animals; Anxiety; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 2000 |
Validation of an ion-trap gas chromatographic-mass spectrometric method for the determination of cocaine and metabolites and cocaethylene in post mortem whole blood.
Topics: Biomarkers; Biotransformation; Calibration; Cocaine; Dopamine Uptake Inhibitors; Drug Synergism; Ethanol; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Reproducibility of Results; Risk Factors; Sensitivity and Specificity | 2000 |
Segmental analysis for cocaine and metabolites by HPLC in hair of suspected drug overdose cases.
Topics: Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Drug Overdose; Forensic Medicine; Hair; Humans | 2000 |
Correlation of the incidence of cocaine and cocaethylene in hair and postmortem biologic samples.
Topics: Autopsy; Cocaine; Cocaine-Related Disorders; Enzyme Multiplied Immunoassay Technique; Ethanol; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Prospective Studies | 2000 |
Cocaine and cocaethylene binding to normal human brain and Alzheimer disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Humans; Male; Middle Aged; Reference Values | 2000 |
Quantitation of cocaine, benzoylecgonine, cocaethylene, methylecgonine, and norcocaine in human hair by positive ion chemical ionization (PICI) gas chromatography-tandem mass spectrometry.
Topics: Biotransformation; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Reproducibility of Results; Substance Abuse Detection | 2000 |
C-fos and egr-1 immediate-early gene induction by cocaine and cocaethylene in rat brain: a comparative study.
Topics: Animals; Autoradiography; Brain; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Early Growth Response Protein 1; Ethanol; Gene Expression Regulation; In Situ Hybridization; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Transcriptional Activation | 2000 |
Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.
Topics: Alcoholism; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiomyopathies; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dogs; Electrocardiography; Ethanol; Prospective Studies; Randomized Controlled Trials as Topic; Time Factors; Ventricular Pressure | 2001 |
Analysis of cocaethylene, benzoylecgonine and cocaine in human urine by high-performance thin-layer chromatography with ultraviolet detection: a comparison with high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cocaine; Sensitivity and Specificity; Ultraviolet Rays | 2001 |
Electrophysiological effects of cocaethylene, cocaine, and ethanol on dopaminergic neurons of the ventral tegmental area.
Topics: Animals; Central Nervous System Depressants; Cocaine; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrophysiology; Ethanol; Extracellular Space; In Vitro Techniques; Ketanserin; Neurons; Rats; Rats, Inbred F344; Serotonin Antagonists; Sulpiride; Ventral Tegmental Area | 2001 |
Ethanol combined with cocaine inhibits amylase release in guinea pig pancreatic lobules.
Topics: Amylases; Animals; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug Combinations; Drug Interactions; Ethanol; Guinea Pigs; In Vitro Techniques; Pancreas; Synaptic Transmission | 2001 |
Crystal structure of a cocaine-binding antibody.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Cations; Cocaine; Crystallography, X-Ray; Drug Design; Humans; Hydrogen Bonding; Immunoglobulin Fab Fragments; Immunotherapy; Mice; Models, Molecular; Protein Conformation; Recombinant Fusion Proteins; Static Electricity | 2001 |
Effects of cocaine and cocaine metabolites on cardiovascular function in squirrel monkeys.
Topics: Animals; Blood Pressure; Cocaine; Heart Rate; Models, Animal; Saimiri | 2001 |
Inhibition of HERG potassium channels by cocaethylene: a metabolite of cocaine and ethanol.
Topics: Cell Line; Cocaine; Ethanol; Gene Expression; Humans; Ion Channel Gating; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Transfection | 2002 |
Cocaethylene and heart disease during murine AIDS.
Topics: Animals; Cardiac Catheterization; Cocaine; Coxsackievirus Infections; Cytokines; Cytomegalovirus Infections; Dopamine Uptake Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Heart; Heart Diseases; Hemodynamics; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Myocardium; Spleen | 2002 |
Evidence for opponent-process actions of intravenous cocaine and cocaethylene.
Topics: Aggression; Animals; Anxiety; Cocaine; Conditioning, Operant; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Time Factors | 2002 |
Cocaethylene's effects on coronary artery blood flow and cardiac function in a canine model.
Topics: Animals; Cocaine; Coronary Circulation; Dogs; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Infusions, Intravenous | 2002 |
Cardiovascular complications of cocaine use: recent points on cocaethylene toxicity.
Topics: Affect; Alcohol Drinking; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Interactions; Humans | 2002 |
Cocaethylene metabolism and interaction with cocaine and ethanol: role of carboxylesterases.
Topics: Animals; Area Under Curve; Carboxylic Ester Hydrolases; Cocaine; Dogs; Drug Interactions; Ethanol; Male | 2003 |
Determination of cocaine, benzoylecgonine and cocaethylene in human hair by solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Cocaine; Hair; Humans; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Closing and inactivation potentiate the cocaethylene inhibition of cardiac sodium channels by distinct mechanisms.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Female; Humans; Muscle Proteins; Myocardium; NAV1.5 Voltage-Gated Sodium Channel; Protein Binding; Sodium Channels; Xenopus | 2003 |
Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves.
Topics: Action Potentials; Anesthetics, Local; Animals; Axotomy; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Lidocaine; Neurons; Patch-Clamp Techniques; Peripheral Nerves; Rats; Sciatic Nerve; Spinal Nerve Roots | 2004 |
Evidence for injurious effect of cocaethylene in human microvascular endothelial cells.
Topics: Antigens, Polyomavirus Transforming; Capillaries; Cell Line; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Cocaine; Culture Media; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Kinetics; L-Lactate Dehydrogenase; Silver Staining | 2004 |
Development of monoclonal antibodies directed against cocaine and cocaethylene: potential new tools for immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cocaine; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunotherapy; Mice; Mice, Inbred BALB C; Radioimmunoassay | 2004 |
Effects of chronic naltrexone treatment in rats on place preference and locomotor activation after acute administration of cocaethylene or ethanol plus cocaine.
Topics: Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Ethanol; Male; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley | 2004 |
Detection of cocaine and cocaethylene in sweat by solid-phase microextraction and gas chromatography/mass spectrometry.
Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sweat | 2004 |
Effects of seven drugs of abuse on action potential repolarisation in sheep cardiac Purkinje fibres.
Topics: Action Potentials; Animals; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Illicit Drugs; In Vitro Techniques; Male; Methamphetamine; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Phencyclidine; Purkinje Fibers; Sheep; Time Factors | 2005 |
Analysis of cocaine and three of its metabolites in hair by gas chromatography-mass spectrometry using ion-trap detection for CI/MS/MS.
Topics: Adolescent; Adult; Calibration; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Solid-phase microextraction for the determination of cocaine and cocaethylene in human hair by gas chromatography-mass spectrometry.
Topics: Adult; Cocaine; Dopamine Uptake Inhibitors; Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Reproducibility of Results | 2006 |
HPLC-DAD determination of opioids, cocaine and their metabolites in plasma.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Codeine; Dopamine Uptake Inhibitors; Female; Forensic Medicine; Humans; Male; Methadone; Morphine; Morphine Derivatives; Pyrrolidines | 2006 |
Application of pericardial fluid to the analysis of morphine (heroin) and cocaine in forensic toxicology.
Topics: Cocaine; Codeine; Dopamine Uptake Inhibitors; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Morphine; Narcotics; Pericardium; Postmortem Changes; Substance Abuse Detection | 2006 |
Determination of cocaine and cocaethylene in urine by solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Molecular Structure; Reproducibility of Results | 2006 |
Cocaethylene affects human microvascular endothelial cell p38 mitogen-activated protein kinase activation and nuclear factor-kappaB DNA-binding activity.
Topics: Capillary Permeability; Cell Line; Cocaine; Dimerization; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Humans; Microcirculation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation | 2006 |
Determination of cocaine and cocaethylene in plasma by solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Substance-Related Disorders | 2007 |
Markers of chronic alcohol use in hair: comparison of ethyl glucuronide and cocaethylene in cocaine users.
Topics: Adolescent; Adult; Alcoholism; Biomarkers; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Glucuronates; Hair; Humans; Male; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2007 |
Interest for delivery of cocaethylene in a sustained release emulsion vs saline evaluated on behavioral sensitization in naive and cocaine-sensitized mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Delayed-Action Preparations; Dopamine Uptake Inhibitors; Emulsions; Locomotion; Male; Mice | 2007 |
Validation of a procedure for the gas chromatography-mass spectrometry analysis of cocaine and metabolites in pericardial fluid.
Topics: Cocaine; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Pericardial Effusion; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2007 |
Cocaethylene as a component in illicit cocaine.
Topics: Cocaine; Crime; Drug and Narcotic Control; Illicit Drugs; South America | 2007 |
Identification of cocaine-contaminated hair: perspectives on a paper.
Topics: Cocaine; Decontamination; Forensic Toxicology; Hair; Humans; Illicit Drugs; Research Design; Specimen Handling; Substance Abuse Detection | 2007 |
Microwave-assisted extraction and HPLC-DAD determination of drugs of abuse in human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Cocaine; Codeine; Forensic Medicine; Humans; Illicit Drugs; Methadone; Microwaves; Morphine; Pyrrolidines; Reproducibility of Results; Solvents; Spectrophotometry, Atomic; Substance Abuse Detection | 2007 |
Determination of cocaine, benzoylecgonine, cocaethylene and norcocaine in human hair using solid-phase extraction and liquid chromatography with tandem mass spectrometric detection.
Topics: Chromatography, Liquid; Cocaine; Hair; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2007 |
Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination.
Topics: Cocaine; Discriminant Analysis; Dopamine Uptake Inhibitors; Drug Contamination; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Substance Abuse Detection | 2008 |
Evidence of temporal cortical dysfunction in rhesus monkeys following chronic cocaine self-administration.
Topics: Animals; Chronic Disease; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Conditioning, Psychological; Discrimination, Psychological; Dopamine Uptake Inhibitors; Female; Macaca mulatta; Male; Prefrontal Cortex; Psychomotor Performance; Reversal Learning; Self Administration | 2008 |
A fast screening MALDI method for the detection of cocaine and its metabolites in hair.
Topics: Cocaine; Coumaric Acids; Hair; Humans; Methanol; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substance Abuse Detection; Temperature; Time Factors; Trifluoroacetic Acid | 2009 |
An automated SPE/LC/MS/MS method for the analysis of cocaine and metabolites in whole blood.
Topics: Chromatography, High Pressure Liquid; Cocaine; Humans; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2008 |
Determination of cocaine and its metabolites using cation-selective exhaustive injection and sweeping-MEKC.
Topics: Buffers; Cations; Chromatography, Micellar Electrokinetic Capillary; Cocaine; Humans; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Solvents; Time Factors | 2008 |
Pharmacodynamic evaluation of the cardiovascular effects after the coadministration of cocaine and ethanol.
Topics: Alcoholism; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular System; Cocaine; Cocaine-Related Disorders; Dogs; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electrocardiography; Ethanol; Heart Rate; Models, Animal; Myocardial Contraction | 2009 |
Occurrence of cocaine in the air of the World's cities. An emerging problem? A new tool to investigate the social incidence of drugs?
Topics: Air Pollutants; Cannabinoids; Cities; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Methadone; Particulate Matter; Substance-Related Disorders | 2009 |
Cocaine and alcohol: a potential lethal duo.
Topics: Adult; Anti-Arrhythmia Agents; Cocaine; Ethanol; Female; Humans; Magnesium Sulfate; Torsades de Pointes | 2009 |
Detection of drugs of forensic importance in postmortem bone.
Topics: Adult; Aged; Aged, 80 and over; Benzodiazepines; Bone and Bones; Cocaine; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Infant; Infant, Newborn; Male; Middle Aged; Narcotics; Pharmaceutical Preparations; Substance-Related Disorders | 2009 |
Detection of cocaine and its metabolites in urine using solid phase extraction-ion mobility spectrometry with alternating least squares.
Topics: Cocaine; Dopamine Uptake Inhibitors; Forensic Toxicology; Humans; Mass Spectrometry; Models, Statistical; Solid Phase Microextraction; Substance Abuse Detection | 2009 |
Optimization of a rapid microwave-assisted extraction method for the simultaneous determination of opiates, cocaine and their metabolites in human hair.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Codeine; Hair; Humans; Illicit Drugs; Microwaves; Morphine; Morphine Derivatives; Narcotics | 2009 |
Simple method for determination of cocaine and main metabolites in urine by CE coupled to MS.
Topics: Cocaine; Electrophoresis, Capillary; Humans; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Neurotoxic and cardiotoxic effects of cocaine and ethanol.
Topics: Adult; Alcoholism; Anti-Arrhythmia Agents; Aphasia; Brain; Carotid Artery, Internal, Dissection; Cerebral Angiography; Cerebral Infarction; Cocaine; Cocaine-Related Disorders; Combined Modality Therapy; Craniotomy; Decompression, Surgical; Electric Countershock; Electrocardiography; Female; Heart Rate; Hemiplegia; Humans; Magnesium Sulfate; Magnetic Resonance Angiography; Tomography, X-Ray Computed; Torsades de Pointes; Treatment Outcome; Ventricular Fibrillation | 2009 |
The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Biological Availability; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cocaine; Dogs; Drug Interactions; Enzyme Inhibitors; Ethanol; Injections, Intravenous; Isoenzymes; Male; Metabolic Clearance Rate; Statistics as Topic | 2010 |
Analysis of hair after contamination with blood containing cocaine and blood containing benzoylecgonine.
Topics: Cocaine; Dopamine Uptake Inhibitors; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Immersion; Specimen Handling; Time Factors | 2010 |
Hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) determination of cocaine and its metabolites benzoylecgonine, ecgonine methyl ester, and cocaethylene in hair samples.
Topics: Calibration; Chromatography, High Pressure Liquid; Cocaine; Hair; Humans; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2010 |
Gas chromatography-mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation.
Topics: Abortion, Induced; Amphetamines; Cocaine; Cotinine; Dronabinol; Female; Forensic Toxicology; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Maternal Exposure; Maternal-Fetal Exchange; Methadone; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Nicotine; Placenta; Pregnancy; Pregnancy Trimester, First; Specimen Handling; Substance Abuse Detection | 2010 |
Quantitation of cocaine, benzoylecgonine, ecgonine methyl ester, and cocaethylene in urine and blood using gas chromatography-mass spectrometry (GC-MS).
Topics: Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Reference Standards; Reproducibility of Results; Solid Phase Extraction | 2010 |
Identification and quantitation of cocaine, benzoylecgonine, and cocaethylene in blood, serum, and plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS).
Topics: Acetonitriles; Chromatography, Liquid; Cocaine; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Solvents; Tandem Mass Spectrometry | 2010 |
Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Chi-Square Distribution; Cocaine; Cocaine-Related Disorders; Critical Care; Female; Humans; Injury Severity Score; Length of Stay; Logistic Models; Male; Middle Aged; Patient Admission; Sex Factors; Statistics, Nonparametric; Wounds and Injuries; Young Adult | 2010 |
Analysis of cocaine and two metabolites in dried blood spots by liquid chromatography with fluorescence detection: a novel test for cocaine and alcohol intake.
Topics: Alcohol Drinking; Blood Specimen Collection; Chromatography, High Pressure Liquid; Cocaine; Desiccation; Ethanol; Female; Humans; Linear Models; Male; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Fluorescence; Substance Abuse Detection | 2010 |
Determination of fatty acid ethyl esters in hair by GC-MS and application in a population of cocaine users.
Topics: Alcoholism; Biomarkers; Calibration; Cocaine; Cocaine-Related Disorders; Esters; Fatty Acids; Gas Chromatography-Mass Spectrometry; Hair; Humans; Reproducibility of Results; Substance Abuse Detection | 2011 |
Cocaethylene formation following ethanol and cocaine administration by different routes.
Topics: Administration, Oral; Adult; Area Under Curve; Behavior; Blood Pressure; Cocaine; Drug Interactions; Ethanol; Female; Half-Life; Heart Rate; Humans; Injections, Intravenous; Male; Placebos; Smoking | 2011 |
Single hair cocaine consumption monitoring by mass spectrometric imaging.
Topics: Cocaine; Hair; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.
Topics: Animals; Bacterial Proteins; Carboxylic Ester Hydrolases; Chromatography, High Pressure Liquid; Cocaine; Hydrolysis; Male; Rats; Rats, Sprague-Dawley; Rhodococcus; Tandem Mass Spectrometry | 2011 |
Chromatographic determination of drugs of abuse in vitreous humor using solid-phase extraction.
Topics: Chromatography, High Pressure Liquid; Cocaine; Codeine; Humans; Illicit Drugs; Morphine Derivatives; Pyrrolidines; Reproducibility of Results; Solid Phase Extraction; Vitreous Body | 2013 |
Hair testing for cocaine and metabolites by GC/MS: criteria to quantitatively assess cocaine use.
Topics: Cocaine; Female; Forensic Pathology; Gas Chromatography-Mass Spectrometry; Hair; Humans; Limit of Detection; Male; Reproducibility of Results; Solid Phase Extraction | 2013 |
Drugs of abuse in wastewater and suspended particulate matter--further developments in sewage epidemiology.
Topics: Cocaine; Czech Republic; Environmental Monitoring; Illicit Drugs; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Pyrrolidines; Sewage; Substance-Related Disorders; Wastewater; Water Pollutants, Chemical; Water Pollution, Chemical | 2012 |
Probing cocaine-antibody interactions in buffer and human serum.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antibody Affinity; Binding, Competitive; Calorimetry; Cattle; Cocaine; Cocaine-Related Disorders; Humans; Immobilized Proteins; Immunotherapy; Kinetics; Mice; Protein Binding; Serum; Serum Albumin; Serum Albumin, Bovine; Surface Plasmon Resonance | 2012 |
Cocaine in sudden and unexpected death: a review of 49 post-mortem cases.
Topics: Adolescent; Adult; Aged; Amphetamines; Analgesics, Opioid; Australia; Benzodiazepines; Cause of Death; Central Nervous System Depressants; Cocaine; Death, Sudden; Ethanol; Fatty Liver; Female; Forensic Pathology; Forensic Toxicology; Heart Diseases; Hepatitis C; Humans; Male; Middle Aged; Narcotics; Young Adult | 2013 |
Cocaethylene as a biomarker to predict heavy alcohol exposure among cocaine users.
Topics: Alcohol Drinking; Biomarkers; Cocaine; Enzyme-Linked Immunosorbent Assay; Ethanol; Fatty Acids; Female; Fetal Alcohol Spectrum Disorders; Gas Chromatography-Mass Spectrometry; Hair; Humans; Predictive Value of Tests; Pregnancy; Sensitivity and Specificity; Solid Phase Microextraction; Substance Abuse Detection | 2012 |
Analysis of skeletal muscle has potential value in the assessment of cocaine-related deaths.
Topics: Adolescent; Adult; Cocaine; Cocaine-Related Disorders; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Male; Myocardium; Narcotics; Quadriceps Muscle; Substance Abuse Detection; Vitreous Body; Young Adult | 2013 |
Determination of cocaine, cocaine metabolites and cannabinoids in single hairs by MALDI Fourier transform mass spectrometry--preliminary results.
Topics: Cannabinoids; Cocaine; Coumaric Acids; Fourier Analysis; Hair; Humans; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Cocaine and specific cocaine metabolites induce von Willebrand factor release from endothelial cells in a tissue-specific manner.
Topics: Brain; Cells, Cultured; Cocaine; Coronary Vessels; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; P-Selectin; Sensitivity and Specificity; Thrombosis; von Willebrand Factor | 2013 |
Development and validation of a single LC-MS/MS assay following SPE for simultaneous hair analysis of amphetamines, opiates, cocaine and metabolites.
Topics: Amphetamines; Analgesics, Opioid; Chromatography, Liquid; Cocaine; Forensic Toxicology; Hair; Humans; Limit of Detection; Male; Narcotics; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2014 |
A direct immersion solid-phase microextraction gas chromatography/mass spectrometry method for the simultaneous detection of levamisole and minor cocaine congeners in hair samples from chronic abusers.
Topics: Chronic Disease; Cocaine; Cocaine-Related Disorders; Gas Chromatography-Mass Spectrometry; Hair; Humans; Levamisole; Solid Phase Microextraction | 2014 |
Examination of sex differences in fatty acid ethyl ester and ethyl glucuronide hair analysis.
Topics: Adult; Alcoholism; Biomarkers; Cocaine; Esters; Fatty Acids; Female; Gas Chromatography-Mass Spectrometry; Glucuronates; Hair; Humans; Male; Sex Characteristics; Substance Abuse Detection | 2014 |
Toxicological findings in a fatal multidrug intoxication involving mephedrone.
Topics: Adult; Bile; Brain Chemistry; Cocaine; Designer Drugs; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Hair; Humans; Illicit Drugs; Lung; Male; Methamphetamine | 2014 |
Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.
Topics: Animals; Butyrylcholinesterase; Catalysis; CHO Cells; Cocaine; Cocaine-Related Disorders; Cricetulus; Ethanol; HEK293 Cells; Humans; Hydrolysis; Kinetics; Male; Molecular Docking Simulation; Rats | 2014 |
Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios.
Topics: Acetaminophen; Acetone; Adolescent; Adult; Aged; Chromatography, Liquid; Coca; Cocaine; Cocaine-Related Disorders; Drug and Narcotic Control; Drug Contamination; Female; Forensic Toxicology; Hair; Humans; Levamisole; Lidocaine; Male; Mass Spectrometry; Mastication; Middle Aged; Plant Leaves; Pyrrolidines; Tea | 2015 |
Ethanol and cocaine: environmental place conditioning, stereotypy, and synergism in planarians.
Topics: Animals; Cocaine; Conditioning, Psychological; Drug Synergism; Ethanol; Lidocaine; Planarians; Stereotyped Behavior | 2014 |
Multi-drug and metabolite quantification in postmortem blood by liquid chromatography-high-resolution mass spectrometry: comparison with nominal mass technology.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Chromatography, Liquid; Citalopram; Cocaine; Codeine; Dextromethorphan; Diphenhydramine; Evaluation Studies as Topic; Forensic Pathology; Humans; Hydrocodone; Hydromorphone; Meperidine; Methadone; Morphine; Oxycodone; Oxymorphone; Pyrrolidines; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry | 2014 |
Genetic and toxicologic investigation of Sudden Cardiac Death in a patient with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) under cocaine and alcohol effects.
Topics: Adult; Arrhythmogenic Right Ventricular Dysplasia; Central Nervous System Depressants; Cocaine; Cocaine-Related Disorders; Death, Sudden, Cardiac; Desmoglein 2; Electrocardiography; Ethanol; Forensic Toxicology; Hair; Heart Arrest; Humans; Male; Mutation; Narcotics; Tachycardia, Sinus | 2015 |
The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice.
Topics: Animals; Antibodies, Monoclonal; Cocaine; Humans; Immunotherapy; Mice; Recombinant Proteins | 2014 |
Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Chemical Phenomena; Cocaine; Disulfides; Fluorometry; Glucans; Humans; Immunoglobulin Fab Fragments; Protein Binding; Recombinant Proteins; Static Electricity | 2015 |
Economical synthesis of 13C-labeled opiates, cocaine derivatives and selected urinary metabolites by derivatization of the natural products.
Topics: Analgesics, Opioid; Biological Products; Carbon-13 Magnetic Resonance Spectroscopy; Cocaine; Codeine; Heroin; Humans; Molecular Structure; Morphine; Morphine Derivatives; Substance Abuse Detection; Urinalysis | 2015 |
Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin.
Topics: Animals; Arrhythmias, Cardiac; beta-Cyclodextrins; Bupivacaine; Cardiotoxicity; Cocaine; Coronary Circulation; Depression, Chemical; Fat Emulsions, Intravenous; Heart; Heart Rate; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley | 2015 |
Comparative effects of cocaine and cocaethylene on alveolar epithelial type II cells.
Topics: Alveolar Epithelial Cells; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cocaine; Colony-Forming Units Assay; Dopamine Uptake Inhibitors; Humans; Illicit Drugs; Oxidative Stress; Reactive Oxygen Species | 2015 |
Development of magnetic molecularly imprinted polymers for solid phase extraction of cocaine and metabolites in urine before high performance liquid chromatography - tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cocaine; Ferrosoferric Oxide; Humans; Limit of Detection; Magnetic Phenomena; Methacrylates; Molecular Imprinting; Nitriles; Polyethylene Glycols; Solid Phase Extraction; Tandem Mass Spectrometry; Ultrasonic Waves; Vinyl Compounds | 2016 |
Norcocaine and cocaethylene distribution patterns in hair samples from light, moderate, and heavy cocaine users.
Topics: Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Limit of Detection; Male; Solid Phase Extraction; Substance Abuse Detection | 2017 |
Development of a method for the determination of cocaine, cocaethylene and norcocaine in human breast milk using liquid phase microextraction and gas chromatography-mass spectrometry.
Topics: Cocaine; Female; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Liquid Phase Microextraction; Milk, Human; Reproducibility of Results; Substance Abuse Detection | 2016 |
Determination of cocaine and its metabolites in plasma by porous membrane-protected molecularly imprinted polymer micro-solid-phase extraction and liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cocaine; Drug Users; Humans; Molecular Imprinting; Polymers; Porosity; Solid Phase Extraction; Tandem Mass Spectrometry; Time Factors | 2016 |
Monitoring of the stability of cocaine and some metabolites in water and oral fluid by a newly developed CE method.
Topics: Body Fluids; Cocaine; Drug Stability; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Saliva; Temperature; Water | 2017 |
Cocaethylene, the in vivo product of cocaine and ethanol, is a narcotic more potent than its precursors.
Topics: Cocaine; Crystallography, X-Ray; Molecular Conformation; Molecular Structure; Narcotics | 2017 |
Determination of hydroxy metabolites of cocaine in hair samples for proof of consumption.
Topics: Cocaine; Dopamine Uptake Inhibitors; Hair; Humans; Hydroxylation; Illicit Drugs; Limit of Detection; Substance Abuse Detection; Tandem Mass Spectrometry | 2018 |
High-Throughput Monitoring of Cocaine and Its Metabolites in Hair Using Microarrays for Mass Spectrometry and Matrix-Assisted Laser Desorption/Ionization-Tandem Mass Spectrometry.
Topics: Adult; Cocaine; Female; Hair; Humans; Limit of Detection; Male; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene.
Topics: Albumins; Animals; Butyrylcholinesterase; Cocaine; Drug Interactions; Electrocardiography; Ethanol; Female; Heart Rate; Humans; Macaca fascicularis; Male; Recombinant Fusion Proteins; Respiration; Troponin I | 2018 |
Determination of cocaine, metabolites and a crack cocaine biomarker in whole blood by liquid-liquid extraction and UHPLC-MS/MS.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Cocaine; Crack Cocaine; Humans; Illicit Drugs; Liquid-Liquid Extraction; Mass Spectrometry; Reproducibility of Results; Substance Abuse Detection | 2018 |
Discrimination between chewing of coca leaves or drinking of coca tea and smoking of "paco" (coca paste) by hair analysis. A preliminary study of possibilities and limitations.
Topics: Acetone; Adolescent; Adult; Biomarkers; Coca; Cocaine; Cocaine-Related Disorders; Female; Hair; Humans; Male; Mastication; Middle Aged; Plant Leaves; Pyrrolidines; Smoking; Substance Abuse Detection; Tea; Young Adult | 2019 |
Nails Analysis for Drugs Used in the Context of Chemsex: A Pilot Study.
Topics: Amphetamine; Chromatography, Liquid; Cocaine; Dronabinol; Forensic Toxicology; Hair; Humans; Hydroxybutyrates; Illicit Drugs; Nails; Psychotropic Drugs; Solid Phase Extraction; Substance Abuse Detection | 2020 |
Simultaneous determination of cocaine, ecgonine methyl ester, benzoylecgonine, cocaethylene and norcocaine in dried blood spots by ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Topics: Blood Stains; Chromatography, High Pressure Liquid; Cocaine; Hematocrit; Humans; Narcotics; Reproducibility of Results; Specimen Handling; Tandem Mass Spectrometry | 2019 |
Simultaneous Determination of Cocaine and Metabolites in Human Plasma Using Solid Phase Micro-Extraction Fiber Tips C18 and UPLC-MS/MS.
Topics: Amines; Chromatography, Liquid; Cocaine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Plasma; Solid Phase Microextraction; Substance Abuse Detection; Tandem Mass Spectrometry | 2020 |
A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics.
Topics: Antibodies, Monoclonal, Humanized; Antigen-Antibody Reactions; Binding Sites, Antibody; Cocaine; Fluorescent Dyes; Fluorometry; Humans; Immunoglobulin Fab Fragments; Ligands; Pyridinium Compounds | 2020 |
Positive findings of ethyl glucuronide in hair of young children from families with addiction background.
Topics: Adolescent; Alcohol Drinking; Behavior, Addictive; Biomarkers; Child; Child, Preschool; Chromatography, Liquid; Cocaine; Cocaine-Related Disorders; Female; Glucuronates; Hair; Humans; Infant; Male; Minors; Palmitic Acids; Parents; Substance Abuse Detection; Tandem Mass Spectrometry | 2020 |
Fiber spray ionization mass spectrometry in forensic chemistry: A screening of drugs of abuse and direct determination of cocaine in urine.
Topics: Analgesics, Opioid; Cannabinoids; Cannabis; Cocaine; Forensic Sciences; Humans; Illicit Drugs; Limit of Detection; Mass Spectrometry; N-Methyl-3,4-methylenedioxyamphetamine; Sensitivity and Specificity; Solvents; Substance Abuse Detection; Tablets | 2020 |
Use of a newly-developed portable capillary electrophoresis analyser to detect drugs of abuse in oral fluid: A case study.
Topics: Adult; Aged; Amphetamines; Cocaine; Female; Fluorescence; Humans; Illicit Drugs; Male; Middle Aged; Saliva; Substance Abuse Detection; Young Adult | 2020 |
Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption.
Topics: Blood Specimen Collection; Chromatography, Liquid; Cocaine; Forensic Medicine; Humans; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |
Stability of Cocaine Compounds in Biological Fluids During Post-Analytical Sample Storage.
Topics: Body Fluids; Chromatography, High Pressure Liquid; Cocaine; Gas Chromatography-Mass Spectrometry; Humans; Narcotics; Specimen Handling; Temperature | 2020 |
Relationship between cocaine and cocaethylene blood concentration with the severity of clinical manifestations.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Cocaine; Emergency Service, Hospital; Ethanol; Female; Humans; Male; Prognosis; Severity of Illness Index | 2021 |
Cocaethylene, simultaneous alcohol and cocaine use, and liver fibrosis in people living with and without HIV.
Topics: Adult; Cocaine; Cross-Sectional Studies; HIV Infections; Humans; Liver Cirrhosis | 2022 |
Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.
Topics: Adult; Cardiotoxicity; Cocaine; Drug Overdose; Emergency Service, Hospital; Ethanol; Heart Arrest; Humans; Hyperlactatemia; Lactic Acid; Prospective Studies; Substance-Related Disorders | 2023 |
Urine Drug Tests Indicate Higher Prevalence of Combined Alcohol and Cocaine Use Compared to Alcohol Together with Cannabis or Amphetamine-A Possible Link to Cocaethylene.
Topics: Amphetamine; Cannabis; Chromatography, Liquid; Cocaine; Cocaine-Related Disorders; Ethanol; Humans; Prevalence; Retrospective Studies; Tandem Mass Spectrometry | 2023 |
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine.
Topics: Cocaine; Ethanol; Kinetics | 2023 |
A comparison of the reinforcing strength of cocaethylene and cocaine in monkeys responding under progressive-ratio and concurrent choice schedules of reinforcement.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Reinforcement Schedule; Self Administration | 2023 |
Mariani wine: What's really in it? Analysis of the most popular tonic drink of the 19th century after 100 years of storage.
Topics: Alkaloids; Caffeine; Chromatography, Liquid; Coca; Cocaine; Tandem Mass Spectrometry; Wine | 2024 |