cobamamide has been researched along with littorine* in 1 studies
1 other study(ies) available for cobamamide and littorine
| Article | Year |
|---|---|
Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process.
The conversion of littorine to hyoscyamine has been investigated by feeding deuterium labelled (RS)-[2-(2)H]-, [3, 3-(2)H(2)]-, [2, 3, 3-(2)H(3)]- phenyllactic acids to transformed root cultures of Datura stramonium. Isolation and GC-MS analyses of the isotope incorporation into the resultant hyoscyamine does not support the involvement of a vicinal interchange process operating during the isomerisation of littorine to hyoscyamine. Additionally a metabolism study with [1'-13C, 3', 3'-(2)H(2)]-hyoscyamine has established that the alkaloid is metabolically stable at C-3' with no evidence for a reversible in vivo oxidation process to the corresponding aldehyde. The data do not support an S-adenosy-L-methionine (SAM 5)/co-enzyme-B(12) mediated process for the isomerisation of littorine to hyoscyamine. Topics: Atropine; Atropine Derivatives; Carbon Isotopes; Cell Extracts; Cells, Cultured; Cobamides; Datura stramonium; Deuterium; Gas Chromatography-Mass Spectrometry; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Plant Roots; S-Adenosylmethionine | 2002 |