Page last updated: 2024-08-22

cobaltous chloride and phenobarbital

cobaltous chloride has been researched along with phenobarbital in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199023 (69.70)18.7374
1990's7 (21.21)18.2507
2000's2 (6.06)29.6817
2010's1 (3.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Couture, J; Dahlström-King, L; Plaa, GL1
Hahnemann, B; Honkakoski, P; Juvonen, R; Lang, MA; Mäenpää, J; Pasanen, M; Pelkonen, O; Raunio, H; Salonpää, P1
Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP1
Alexander, J; Mikalsen, A; Ryberg, D1
Fujino, S; Hoshi, K; Senda, N1
Brown, PI; Rankin, GO; Richmond, CD; Shih, HC; Teets, VJ; Yang, DJ1
Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G1
Lindup, WE; Orton, TC; Rosenbaum, SE1
Chengelis, CP; Neal, RA1
Padmanaban, G; Ravishankar, H3
Bien, E; Witt, M1
Das, M; Mukhtar, H; Seth, PK; Srivastava, SP1
Narimatsu, S; Watanabe, K; Yamamoto, I; Yoshimura, H1
Bolt, HM; Filser, JG; Schmiedel, G1
de Valkeneer, FD; Gilbert, PJ; Mercier, M; Poncelet, F; Rollmann, B; Rondelet, J1
Avren'eva, LI; Kravchenko, LV; Tutel'ian, VA1
Babany, G; Cobert, B; Funck-Brentano, C; Larrey, D; Pessayre, D; Tinel, M1
Watanabe, K; Yoshizawa, I1
Bien, E1
Buchet, JP; de Hoffmann, E; Lauwerys, R; Scailteur, V1
Fischer, E; Gregus, Z; Varga, F1
Aune, T; Dybing, E; Nelson, SD1
Clark, JD; Hatch, RC; Jain, AV; Weiss, R1
Belvedere, G; Cantoni, L; Cantoni, R; Salmona, M; Vignazia, E1
Anestis, DK; Beers, KW; Brown, PI; Nicoll, DW; Rankin, GO1
Amatsu, T; Asaka, Y; Kanamura, S; Watanabe, J1
Nirodi, CS; Padmanaban, G; Prabhu, L; Ram, N; Sultana, S1
Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T1
Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E1
Ali, M; Dayal, M; Dhawan, A; Dwivedi, UN; Parmar, D; Seth, PK1
Numazawa, S; Shindo, S; Shizu, R; Yoshida, T1

Other Studies

33 other study(ies) available for cobaltous chloride and phenobarbital

ArticleYear
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
    Toxicology letters, 1992, Volume: 63, Issue:3

    Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ketones; Liver; Male; Methylcholanthrene; Mirex; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Sprague-Dawley; Taurolithocholic Acid

1992
Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.
    The Biochemical journal, 1992, Aug-15, Volume: 286 ( Pt 1)

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Cell Nucleus; Cobalt; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenobarbital; Polymerase Chain Reaction; Pyrazoles; RNA, Messenger; Steroid Hydroxylases

1992
Role of cytochrome P450 in the control of the production of erythropoietin.
    Life sciences, 1990, Volume: 47, Issue:2

    Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured

1990
Microsomal metabolism of hexavalent chromium. Inhibitory effect of oxygen and involvement of cytochrome P-450.
    Chemico-biological interactions, 1989, Volume: 69, Issue:2-3

    Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromium; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Kinetics; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values

1989
Acute effect of amitriptyline, phenobarbital or cobaltous chloride on delta-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver.
    Japanese journal of pharmacology, 1989, Volume: 50, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Amitriptyline; Animals; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains

1989
Nephrotoxicity of N-(3,5-dichlorophenyl)succinimide metabolites in vivo and in vitro.
    Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3

    Topics: Animals; Cobalt; Fungicides, Industrial; In Vitro Techniques; Kidney; Male; p-Aminohippuric Acid; Phenobarbital; Rats; Rats, Inbred F344; Succinimides

1988
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme.
    The Journal of biological chemistry, 1987, Dec-15, Volume: 262, Issue:35

    Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger

1987
Practolol: aspects of its metabolism and ocular binding in the hamster.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:6

    Topics: Animals; Cobalt; Cricetinae; Eye; Male; Mesocricetus; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Practolol

1986
Oxidative metabolism of carbon disulfide by isolated rat hepatocytes and microsomes.
    Biochemical pharmacology, 1987, Feb-01, Volume: 36, Issue:3

    Topics: Acetazolamide; Animals; Carbon Disulfide; Cobalt; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Sulfur

1987
Regulation of cytochrome P-450 gene expression. Studies with a cloned probe.
    The Journal of biological chemistry, 1985, Feb-10, Volume: 260, Issue:3

    Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; DNA; Gene Expression Regulation; Male; Microsomes, Liver; Nucleic Acid Hybridization; Phenobarbital; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic

1985
Influence of pyrazolones on hepatic glutathione in rats.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1985, Volume: 8

    Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide

1985
Effects of mixed-function oxidase modifiers on neurotoxicity of acrylamide in rats.
    Biochemical pharmacology, 1985, Apr-01, Volume: 34, Issue:7

    Topics: Acrylamide; Acrylamides; Animals; Cobalt; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Male; Mixed Function Oxygenases; Nervous System; Paralysis; Phenobarbital; Rats; Rats, Inbred Strains

1985
Turnover of messenger RNA, apoprotein and haem of cytochrome P-450b + e induced by phenobarbitone in rat liver.
    The Biochemical journal, 1985, Jul-01, Volume: 229, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Heme; Liver; Male; Phenobarbital; Rats; RNA, Messenger

1985
8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes.
    Biochemical and biophysical research communications, 1982, Dec-15, Volume: 109, Issue:3

    Topics: Animals; Cobalt; Dronabinol; Isomerism; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; NADP; Phenobarbital

1982
Rat liver microsomal transformation of ethene to oxirane in vitro.
    Toxicology letters, 1983, Volume: 19, Issue:3

    Topics: Alkylation; Animals; Biotransformation; Cobalt; Ditiocarb; Ethylene Oxide; Ethylenes; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains

1983
Quantitative correlation between the metabolism and the mutagenic activity of N-nitrosopyrrolidine.
    Toxicology, 1984, Volume: 29, Issue:3

    Topics: Animals; Biotransformation; Butylene Glycols; Cobalt; Hydroxylation; Male; Microsomes, Liver; Mutagenicity Tests; N-Nitrosopyrrolidine; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium

1984
[Mechanism of the protective effect of modifiers of the liver enzyme systems metabolyzing xenobiotics in acute T-2 mycotoxicosis].
    Doklady Akademii nauk SSSR, 1984, Volume: 276, Issue:5

    Topics: Acute Disease; Animals; Cobalt; Drug Evaluation, Preclinical; Enzyme Induction; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Sesquiterpenes; T-2 Toxin

1984
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3

    Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Glutathione; Male; Methylcholanthrene; Oleandomycin; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin

1983
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver.
    Archives of biochemistry and biophysics, 1983, Volume: 225, Issue:1

    Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Triazoles

1983
Induction of liver microsomal 2-hydroxylation of estradiol 17-sulfate by phenobarbital in male rat.
    Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:6

    Topics: Animals; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 Enzyme System; Estradiol; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains

1983
[Effect of pyrazolone derivatives on the level of reduced glutathione in rat liver].
    Biomedica biochimica acta, 1983, Volume: 42, Issue:5

    Topics: Aminopyrine; Animals; Antipyrine; Cobalt; Female; Glutathione; Liver; Male; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains

1983
Study on in vivo and in vitro metabolism of dimethylformamide in male and female rats.
    Toxicology, 1984, Volume: 29, Issue:3

    Topics: Aminopyrine; Animals; Biotransformation; Cobalt; Dimethylformamide; Drug Interactions; Female; Formamides; Injections, Intraperitoneal; Liver; Male; Microsomes; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors

1984
Effects of cobalt chloride and cycloheximide on the hepatic microsomal enzyme system and biliary excretion rate in control and phenobarbital-pretreated rats.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 262, Issue:2

    Topics: Animals; Bile; Bromcresol Green; Cobalt; Cycloheximide; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Sleep

1983
Mutagenic activation of 2,4-diaminoanisole and 2-amino-fluorene by isolated rat liver nuclei and microsomes.
    Chemico-biological interactions, 1980, Volume: 31, Issue:1

    Topics: Animals; Anisoles; Benzoflavones; beta-Naphthoflavone; Cell Nucleus; Cobalt; Flavonoids; Fluorenes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mutagens; NADP; Phenobarbital; Phenylenediamines; Rats; Salmonella typhimurium

1980
Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor.
    American journal of veterinary research, 1982, Volume: 43, Issue:1

    Topics: Animals; Atractyloside; Benzoflavones; beta-Naphthoflavone; Cobalt; Cysteine; Glycosides; Kidney Tubules; Lethal Dose 50; Liver; Male; Maleates; Phenobarbital; Phenylbutazone; Piperonyl Butoxide; Plants, Toxic; Rats; Rats, Inbred Strains; Stanozolol

1982
Non-linear kinetics of microsomal styrene monooxygenase after phenobarbital pre-treatment.
    Experientia, 1980, Jun-15, Volume: 36, Issue:6

    Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Styrenes

1980
Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat.
    Toxicology, 1993, Nov-12, Volume: 84, Issue:1-3

    Topics: Animals; Body Weight; Cobalt; Drug Synergism; Fungicides, Industrial; Injections, Intraperitoneal; Kidney; Male; Microsomes; Organ Size; Phenobarbital; Piperonyl Butoxide; Proteinuria; Rats; Rats, Inbred F344; Succinimides

1993
Endoplasmic reticulum proliferates without an increase in cytochrome P-450 in hepatocytes of mice treated with phenobarbital and cobalt chloride.
    European journal of cell biology, 1995, Volume: 68, Issue:3

    Topics: Animals; Cells, Cultured; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Liver; Male; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Phospholipids

1995
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver.
    The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorides; Cobalt; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferric Compounds; Gene Expression Regulation, Enzymologic; Heme; Hemin; Liver; Molecular Weight; Nuclear Proteins; Phenobarbital; Protoporphyrins; Rats; RNA, Messenger; Steroid Hydroxylases; Transcription, Genetic

1997
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.
    Molecular pharmacology, 1999, Volume: 56, Issue:1

    Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine

1999
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
    Archives of biochemistry and biophysics, 2002, Jun-01, Volume: 402, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E

2002
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2003, Volume: 41, Issue:3

    Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Insecticides; Male; Methylcholanthrene; Motor Activity; Nervous System Diseases; Neurotoxins; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Tremor

2003
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression.
    Toxicology letters, 2013, May-23, Volume: 219, Issue:2

    Topics: Animals; Blotting, Western; Chromatin Immunoprecipitation; Cobalt; Constitutive Androstane Receptor; Gene Expression Regulation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Immunoprecipitation; Male; Mice; Mice, Inbred C3H; Phenobarbital; Plasmids; Real-Time Polymerase Chain Reaction; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear

2013