cobaltous chloride has been researched along with cobalt in 1796 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 305 (16.98) | 18.7374 |
| 1990's | 258 (14.37) | 18.2507 |
| 2000's | 455 (25.33) | 29.6817 |
| 2010's | 681 (37.92) | 24.3611 |
| 2020's | 97 (5.40) | 2.80 |
| Authors | Studies |
|---|---|
| Couture, J; Dahlström-King, L; Plaa, GL | 1 |
| Bulavka, AV; Tushevsky, VF; Zinchuk, VS | 1 |
| Luxoro, M; Nassar-Gentina, V | 1 |
| Kössl, M; Richardson, GP; Russell, IJ | 1 |
| Jain, AK; Kada, T; Kuroda, Y; Tezuka, H | 1 |
| Jungermann, K; Kietzmann, T; Probst, I; Schmidt, H | 1 |
| Andrus, CH; Kaminski, DL; Schneider, TA; Wittgen, CM | 1 |
| Cornelius, CE; Freedland, RA; Rodgers, PA | 1 |
| Abe, M; Anderson, CH; Becker, RP; Deddish, PA; Erdös, EG; Nagae, A; Skidgel, RA; Tan, F | 1 |
| Hamann, SR; Holtman, JR; Martin, WR | 1 |
| de Fine Olivarius, F; Menné, T | 1 |
| Ikarashi, Y; Nakamura, A; Ohno, K; Tsuchiya, T | 1 |
| Dzhuraev, KhN; Nasriddinova, NN | 1 |
| Sanchez-Chapula, J | 1 |
| Baradziej, S; Trzebski, A | 1 |
| Ikarashi, Y; Nakamura, A; Tsuchiya, T | 1 |
| Gasanov, GG; Gulieva, TT; Mamedov, ZG | 1 |
| Hahnemann, B; Honkakoski, P; Juvonen, R; Lang, MA; Mäenpää, J; Pasanen, M; Pelkonen, O; Raunio, H; Salonpää, P | 1 |
| Demedts, M; Lewis, CP; Nemery, B | 2 |
| Cheramy, A; Galli, T; Glowinski, J; Lavielle, S; Serval, V | 1 |
| Kilinç, K; Rouhani, R | 1 |
| Bruner, MW; Burke, CJ; Cordingley, MG; LaFemina, RL; Middaugh, CR; Robbins, HL; Ryan, JA; Sanyal, G; Zeft, AS | 1 |
| Demedts, M; Lauweryns, JM; Nemery, B; Vanlommel, S; Verbeken, EK | 1 |
| Camner, P; Curstedt, T; Jarstrand, C; Johansson, A; Rasool, O | 1 |
| Huang, X; Mooney, RD; Rhoades, RW | 1 |
| Dennis, M; Kolattukudy, PE | 1 |
| Bachmann, KA; Madhira, MS; Rankin, GO | 1 |
| Chang, JP; Jobin, RM | 1 |
| Bennett, MR; Ho, S | 1 |
| Bagdasarian, MS; Bazhenova, AF; Natochin, IuV; Shakhmatova, EI | 1 |
| Balasubramanian, AS; Panneerselvam, K | 1 |
| Hoyland, J; Mason, WT; Rawlings, SR | 1 |
| Hopfer, SM; Peracha, H; Plowman, MC; Sunderman, FW | 1 |
| Ihara, T; Kurishita, A | 1 |
| Belehradek, J; Mir, LM; Poddevin, B | 1 |
| Avendano, G; Gan, J; Iuvone, PM | 1 |
| Ginzberg, R; Highstein, SM; Schessel, DA | 1 |
| Palit, S; Sharma, A; Talukder, G | 2 |
| Bosco, D; Chanson, M; Giordano, E; Meda, P; Soria, B | 1 |
| Frydman, J; Frydman, RB; Tomaro, ML | 1 |
| Herness, MS | 1 |
| Batink, HD; van Heiningen, PN; van Zwieten, PA | 1 |
| Haselton, JR; Kaufman, MP; Padrid, PA | 1 |
| Berman, JD; Fiedler, J; Monroe, FL; Ray, P | 1 |
| Malpeli, JG; Mignard, M | 1 |
| Data, PG; Di Giulio, C; Lahiri, S | 1 |
| Dutta, GP; Pandey, VC; Sahni, SK; Saxena, N; Tekwani, BL | 1 |
| Benjamin, PR; Ferguson, GP | 1 |
| Morita, H; Ogawa, HI; Umeda, M | 1 |
| Ghosh, A; Ghosh, AK; Palit, S; Sen, S; Sharma, A; Talukder, G | 1 |
| Abraham, NG; Beru, N; Goldwasser, E; Hermine, O; Levere, RD; Lin, JH | 1 |
| Cheun, JE; Yeh, HH | 1 |
| Delves, HT; Griffin, SJ; Mucklow, ES; Suchak, B | 1 |
| Chen, C; Israel, JM; Vincent, JD; Zhang, J | 1 |
| Mehendale, HM; Thakore, KN | 1 |
| Masaki, H; Sakon, K; Suzuki, K; Tezuka, T; Yamamura, T | 1 |
| Adamek, GD; Daston, MM; Gesteland, RC | 1 |
| Logan, SD; Spanswick, D | 1 |
| Dickens, CJ; Gillespie, JI; Greenwell, JR; Hutchinson, P | 1 |
| Chopikashvili, LV; L'vova, GN; Vasil'eva, IM; Zasukhina, GD | 1 |
| Fujimori, T; Jencks, WP | 1 |
| Sawai, T; Udagawa, T; Yamaguchi, A | 1 |
| Kumar, GP; Laloraya, M; Laloraya, MM | 1 |
| Aomine, M; Arita, M; Ito, S; Nobe, S; Takaki, R | 1 |
| Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP | 1 |
| Kever, EE; Natochin, IuV; Strashko, SV; Zimina, TM | 1 |
| Gordon, TR; Kocsis, JD; Waxman, SG | 1 |
| Aravindakshan, M; Bhilwade, HN; Chaubey, RC; Chauhan, PS | 1 |
| Abraham, NG; Lin, JH; Martasek, P; Villalon, P | 1 |
| Kada, T; Kuroda, Y; Yokoiyama, A | 1 |
| Maines, MD; Sun, Y | 1 |
| Ishikawa, T; Kawakami, Y; Koyama, I | 1 |
| Donnelly, DF; Getting, PA; Haddad, GG | 1 |
| Hasselgren, PO; Li, SJ; Nordström, G; Säljö, A | 1 |
| Balla, I; Balla, T; Enyedi, P; Hajnóczky, G; Rohács, T; Spät, A | 1 |
| Beug, H; Birnstiel, ML; Cotten, M; Kirlappos, H; Längle-Rouault, F; Mechtler, K; Wagner, E; Zenke, M | 1 |
| Condon, RE; Doumas, BT; Frantzides, CT; Garancis, JC | 2 |
| Andrews, GK; Dietert, RR; Fleet, JC; Golemboski, KA; McCormick, CC | 1 |
| Diliberto, EJ; Fricker, LD; Rigual, RJ; Viveros, OH | 1 |
| Beru, N; Goldwasser, E; Smith, D | 1 |
| Budelmann, BU; Hanlon, RT; Novicki, A | 1 |
| Kurtz, A; Scholz, H | 1 |
| Bezrukov, SM; Natochin, IuV; Pokrovskiĭ, VG | 1 |
| Bers, DM; MacLeod, KT | 1 |
| Meyer, DL; von Bartheld, CS | 1 |
| Löfström, A; Wigzell, H | 1 |
| Foder, B; Scharff, O | 1 |
| Croll, RP | 1 |
| Adaman, O; Bekier, A; Lütolf, UM; Wespi, HH; Willi, A | 1 |
| Hall, WM; Leise, EM; Mulloney, B | 1 |
| Amar, M; Dagher, G; Khefif, A | 1 |
| Bilbaut, A; Hernandez-Nicaise, ML; Leech, CA; Meech, RW | 1 |
| Brigant, JL; Legendre, P; Vincent, JD | 1 |
| Holl, RW; Leong, DA; Thorner, MO | 1 |
| Brubaker, PL | 1 |
| Bell, AN; Lockard, VG; Mehendale, HM; Young, RA | 1 |
| Martini, M; Rossi, ML | 2 |
| DeLellis, RA; Hiort, O; Kwan, PW | 1 |
| Collin, SP | 2 |
| Gruszczyńska, M; Niebrój, T | 2 |
| Cavalié, A; Grant, AO; Hofmann, F; Pelzer, D; Pelzer, S; Sieber, M; Trautwein, W | 1 |
| Alexander, J; Mikalsen, A; Ryberg, D | 1 |
| Allenby, CF; Basketter, DA | 1 |
| Kuroiwa, Y; Numazawa, S; Oguro, T; Yoshida, T | 2 |
| Friesen, HG; Gellersen, B; Wagner, GF | 1 |
| Kimura, Y; Watanabe, K; Yano, S | 1 |
| Brahmachari, SK; Choudhury, D; Ramesh, N; Rao, KE; Sasisekharan, V | 1 |
| Church, J; McLennan, H | 1 |
| Bers, DM; Merrill, DB | 1 |
| Gohda, H; Narimatsu, S; Yamamoto, I; Yoshimura, H | 1 |
| Baruffaldi, A; Cucchi, C | 1 |
| Behera, HN; Mishra, G | 1 |
| Hendriks, D; Lommaert, MP; Scharpé, S; van Sande, M | 1 |
| Fujino, S; Hoshi, K; Senda, N | 2 |
| Deddish, PA; Erdös, EG; Skidgel, RA | 1 |
| Brown, SA; Crowe, TD; Merritt, K | 1 |
| Igarashi, K; Ito, E; Kakinuma, Y; Kobayashi, M; Ohizumi, Y; Terao, K; Yasumoto, T | 1 |
| Cavelier, C; Foussereau, J; Gille, P; Zissu, D | 1 |
| Corbella, J; Domingo, JL; Llobet, JM | 1 |
| Hoshi, K; Igarashi, T; Kitagawa, H; Satoh, T; Senda, N; Ueno, K | 2 |
| Goncharevskaya, OA | 1 |
| Hullihen, J; Pedersen, PL; Williams, N | 1 |
| Hertz, L; Palaiologos, G; Schousboe, A | 1 |
| Barsigian, C; Fellin, FM; Jain, A; Martinez, J | 1 |
| Lannoo, MJ; Maler, L; Zakon, H | 1 |
| Kohno, H; Taketani, S; Tokunaga, R; Yoshinaga, T | 1 |
| Debusschere, KM; Degreef, HJ; Dooms-Goossens, AE; Dupré, KM; Gevers, DM; Loncke, JP; Snauwaert, JE | 1 |
| Hankins, MW; Ruddock, KH | 1 |
| Grimalt, F; Romaguera, C; Vilaplana, J | 1 |
| Billingsley, ML; Lovenberg, W; Velletri, PA | 1 |
| Hattori, Y; Hayashi, Y; Hori, Y; Moriwaki, A; Sunami, T | 1 |
| Lee, C; Malpeli, JG | 1 |
| Szabo, M | 1 |
| Jansen, AP; Steigstra, H; van der Ploeg, PH; van Kampen, EJ; Zwart, A | 1 |
| Braquet, P; Lauzière, M; Sirois, P | 1 |
| Cuttler, L; Szabo, M; Welsh, JB | 1 |
| O'Leary, MH; Paneth, P | 1 |
| Huang, YX | 1 |
| Colby, CL | 1 |
| Inoue, T; Kuroda, Y | 1 |
| Abraham, NG; Mullane, KM; Pinto, A | 1 |
| Chhabra, R; Datta, K; Singh, NK | 1 |
| Licht, P; Porter, DA | 1 |
| Coleman, JE; Giedroc, DP | 1 |
| Matsunaga, T; Nagata, K; Oguri, K; Tanaka, E; Yoshimura, H | 1 |
| Hall, TR; Harvey, S; Lam, SK | 1 |
| Ahmed, AE; Ives, K; Jenkins, VK; Perry, RR | 1 |
| Maines, MD; Rowley, PT; Trakshel, GM | 1 |
| Hirst, JJ; Jenkin, G; Rice, GE; Thorburn, GD | 1 |
| Gramsbergen, JB; Korf, J; Loopuijt, L; Paans, AM; Vaalburg, W; Veenma-van der Duin, L | 1 |
| Casey, JP; Everson, GW; Normann, SA | 1 |
| Hamberger, A; Lazarewicz, JW; Lehmann, A | 1 |
| Fischer, T; Rystedt, I | 1 |
| Murrain, M; Ritzmann, RE | 1 |
| Chengelis, CP | 1 |
| Aw, TY; Fernandez-Checa, JC; Kaplowitz, N; Ookhtens, M; Ren, C | 1 |
| Cannistraci, C; Cristaudo, A; Picardo, M; Santucci, B | 1 |
| Ashrafi, SH; Eisenmann, DR; Liss, R; Zaki, AE | 1 |
| Brown, PI; Rankin, GO; Richmond, CD; Shih, HC; Teets, VJ; Yang, DJ | 1 |
| Fujimoto, Y; Shimamori, Y; Watanabe, Y | 1 |
| Fujimura, N; Goto, S; Kusaka, Y; Morimoto, K; Shirakawa, T | 1 |
| Bacon, JP; Humbel, U; Peters, BH; Pozza, MF; Tyrer, NM | 1 |
| Kato, Y; Liu, SY; Niyitani, Y; Ogawa, HI; Sakata, K; Tsuruta, S | 1 |
| Kharab, P; Singh, I | 2 |
| Imada, Y; Joho, M; Murayama, T | 1 |
| Jayarama Bhat, G; Padmanaban, G | 1 |
| Sunderman, FW; Zaharia, O | 1 |
| Bhat, GJ; Padmanaban, G | 1 |
| Agricola, H; Birkenbeil, H; Pass, G; Penzlin, H | 1 |
| Ashrafi, SH; Eisenmann, DR; Zaki, AE | 2 |
| Butler, SV; Peters, BH; Tyrer, NM | 1 |
| Bovelet, K; Kühn, B; Legrum, W | 1 |
| Ikekawa, N; Kada, T; Nomoto, M; Shirasu, Y | 1 |
| Inouye, T; Jyosui, S; Kakimoto, K; Kato, Y; Morishita, M; Niyitani, Y; Ogawa, HI; Sakata, K; Tsuruta, S | 1 |
| Escoubet, B; Griffaton, G; Lechat, P; Samuel, JL | 1 |
| Caponnetto, A; Rondinone, R | 2 |
| Gee, SJ; LeValley, SE; Tyson, CA | 1 |
| Boger, JR; Deal, DL; Francovitch, RJ; Menzel, DB; Tayyeb, MI; Valentini, JE; Wolpert, RL | 1 |
| Hu, JF; Zhang, BY | 1 |
| Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G | 1 |
| Bommer, M; Herz, A; Kley, N; Liebisch, D; Noble, E | 1 |
| Kaniwa, MA | 1 |
| DeMaster, EG; Nagasawa, HT; Shirota, FN | 1 |
| Bolsover, SR | 1 |
| Lindup, WE; Orton, TC; Rosenbaum, SE | 1 |
| Belovetskaia, IV; Kaliman, PA | 1 |
| Kazakov, VN; Krizhanovskaia, EV; Makarov, VP; Nefedov, VP; Tashenov, EK | 1 |
| Chengelis, CP; Neal, RA | 1 |
| Padmanaban, G; Ravishankar, H | 3 |
| Klaassen, CD; Stelzer, KJ | 1 |
| Appelgren, B; Moberg, LE; Sjöstrand, NO | 1 |
| Bien, E; Witt, M | 1 |
| Bers, DM; Reeves, JP; Sutko, JL | 1 |
| Drummond, GS; Kappas, A; Sardana, MK | 1 |
| Hiraga, K; Nakagawa, Y; Nakao, T; Tayama, K | 1 |
| Das, M; Mukhtar, H; Seth, PK; Srivastava, SP | 1 |
| French, AS | 1 |
| el Kousy, NM; Moussa, BA | 1 |
| Brown, EL; Bundy, KJ; Delahunty, CM; Kelly, RG | 1 |
| Domingo, JL; Llobet, JM; Tomás, JM | 1 |
| Balaban, PM; Lavretskaia, EF; Timashov, VP; Zakahrov, IS | 1 |
| Feng, GJ; Wu, XR; Zhao, DY; Zuo, QH | 1 |
| Jansen, CT; Kalimo, K; Lammintausta, K; Pitkänen, OP | 1 |
| Camner, P; Curstedt, T; Jarstrand, C; Johannsson, A; Robertson, B; Wiernik, A | 1 |
| Kamenetskaia, TsL; Levin, GS | 1 |
| Dueñas, JL; Panigel, M; Wegmann, R | 1 |
| Karis, MA; Menzel, DB; Williams, SJ | 1 |
| Guha, C; Mookerjee, A | 1 |
| Burch, BD; Malpeli, JG | 1 |
| Böhlen, P; Brazeau, P; Esch, F; Guillemin, R; Ling, N; Mougin, C | 1 |
| Kitchin, KT | 1 |
| Antonov, S; Boiadzhieva, A; Dilov, P; Iotov, M | 1 |
| Johannessen, JN; Mayer, DJ; Watkins, LR | 1 |
| Al-Tawil, NG; Marcusson, JA; Möller, E | 1 |
| Nordlind, K | 2 |
| Grimalt, F; Lecha, M; Mascaro, JM; Muniesa, AM; Romaguera, C | 1 |
| Nordlind, K; Thyberg, J | 1 |
| Brooks, JC; Burke, DH; Treml, SB | 1 |
| van Ketel, WG | 1 |
| Ito, F; Kaneko, N; Katsuta, N; Komatsu, Y | 1 |
| Klysik, J; Larson, JE; Stirdivant, SM; Wells, RD; Zacharias, W | 1 |
| Kashiwayanagi, M; Kurihara, K; Miyake, M | 1 |
| Narimatsu, S; Watanabe, K; Yamamoto, I; Yoshimura, H | 1 |
| Bolt, HM; Filser, JG; Schmiedel, G | 1 |
| Henze, A; Nordlind, K | 1 |
| de Valkeneer, FD; Gilbert, PJ; Mercier, M; Poncelet, F; Rollmann, B; Rondelet, J | 1 |
| Atwater, I; Dawson, CM; Ferrer, R; Rojas, E; Soria, B | 1 |
| Kwiatkowska, J; Stasiak, K; Tyran, W; Ujec, M | 1 |
| Albano, EF; Cheeseman, KH; Slater, TF; Tomasi, A | 1 |
| Mitchell, JB; Russo, A | 1 |
| Dohi, T; Kitayama, S; Morita, K; Tsujimoto, A | 1 |
| Pathak, DN; Roy, D; Singh, R | 1 |
| Avren'eva, LI; Kravchenko, LV; Tutel'ian, VA | 1 |
| Domingo, JL; Llobet, JM | 3 |
| Van Harreveld, A | 1 |
| Babić, M; Japundzić, I; Japundzić, M | 1 |
| Atarashi, H; Elharrar, V; Surawicz, B | 1 |
| Jourdon, P | 1 |
| Smith, AG; Smith, AN | 1 |
| Fisher, AA | 1 |
| Camner, P; Casarett-Bruce, M; Curstedt, T; Jarstrand, C; Johansson, A; Lundborg, M; Robertson, B; Wiernik, A | 1 |
| Babany, G; Cobert, B; Funck-Brentano, C; Larrey, D; Pessayre, D; Tinel, M | 1 |
| Watanabe, K; Yoshizawa, I | 1 |
| Bien, E | 1 |
| Govind, CK; Young, RE | 1 |
| Kondo, H; Toyoda, J | 1 |
| Fawade, MM; Pawar, SS | 1 |
| de la Iglesia, FA; Dhami, MS; DiFonzo, CJ; Feuer, G; Martin, RA | 1 |
| Buchet, JP; de Hoffmann, E; Lauwerys, R; Scailteur, V | 1 |
| Triggs, WJ; Willmore, LJ | 1 |
| Brown, BL; Merritt, JE | 1 |
| Awruch, J; Frydman, B; Frydman, RB; Tomaro, ML | 2 |
| Camner, P; Curstedt, T; Johansson, A; Robertson, B | 1 |
| Camner, P; Lundborg, M | 1 |
| Kada, T; Mochizuki, H | 1 |
| Altman, JS; Hackney, CM | 1 |
| Inoue, T; Kada, T; Ohta, Y; Sadaie, Y | 1 |
| Hayashi, N; Kikuchi, G | 1 |
| Fravert, D; Hook, JB; Hsu, CY; Kuo, CH; Tune, BM | 1 |
| Bennett, WM; Elliott, WC; Houghton, DC; Hunter-Baines, J; Koski, J; Lynn, RK | 1 |
| Malpeli, JG | 1 |
| Koshcheev, AK; Livshits, OD | 1 |
| Bolger, GT; Gengo, P; Janis, RA; Klockowski, R; Luchowski, E; Siegel, H; Triggle, AM; Triggle, DJ | 1 |
| Fischer, E; Gregus, Z; Varga, F | 1 |
| Kappas, A; Sardana, MK; Sassa, S | 1 |
| Okubo, S | 1 |
| Aune, T; Dybing, E; Nelson, SD | 1 |
| Clapin, DF; Metuzals, J; Tasaki, I; Terakawa, S | 1 |
| Leong, J; Yang, CC | 1 |
| Clark, JD; Hatch, RC; Jain, AV; Weiss, R | 1 |
| Bennett, JL; Pax, RA; Semeyn, DR | 1 |
| Bonkowsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR; Smith, EL | 1 |
| Rubin, JJ; Willmore, LJ | 1 |
| Menzel, DB; Williams, SJ | 1 |
| Collins, MA; Cottrell, RC; Gangolli, SD; Harris, RA; Lake, BG; Longland, RC; Phillips, JC | 1 |
| de Meester, C; Duverger-Van Bogaert, M; Lambotte-Vandepaer, M; Mercier, M; Poncelet, F; Rollmann, B | 1 |
| Koike, S; Kuno, Y; Tochihara, N | 1 |
| Mahmood, HA; Marks, V | 1 |
| Kitagawa, H; Naminohira, S; Saito, H; Sakai, T; Ueno, K | 1 |
| Larsen, FS; Larsen, PO; Schmidt, H; Søgaard, H | 1 |
| Belvedere, G; Cantoni, L; Cantoni, R; Salmona, M; Vignazia, E | 1 |
| Goebeler, M; Meinardus-Hager, G; Roth, J; Sorg, C | 1 |
| Itoh, T; Iwata, H; Kakimoto, K; Kato, Y; Ogawa, HI; Okada, T; Ryo, H; Sakata, K; Shibahara, T; Tsuruta, S | 1 |
| Erlij, D; Escalante, B; Falck, JR; McGiff, JC | 1 |
| Ando, A; Ando, I | 1 |
| Bloom, FE; Raber, J | 1 |
| Bröcker, EB; Goebeler, M; Roth, J; Schulze-Osthoff, K; Sorg, C | 1 |
| Becker, K; Edwards, G; Johnson, JB | 1 |
| Hébraud, M; Montel, MC; Seronie, MP; Talon, R | 1 |
| Immenschuh, S; Iwahara, S; Katz, N; Muller-Eberhard, U; Nell, C; Satoh, H | 1 |
| Calaresu, FR; Ermirio, R; Molinari, C; Ruggeri, P | 1 |
| Casas-Bejar, J; Stokes, K; Urbanski, P; Zhao, Q | 1 |
| Klein, DC; Schaad, NC; Yu, L | 1 |
| Caldas, LR; Cardoso, JS; Guillobel, HC; Leitão, AC; Soares, RA | 1 |
| Bulloch, AG; Culver, T; Lukowiak, K; Ridgway, RL; Syed, NI | 1 |
| Goebeler, M; Goerdt, S; Meinardus-Hager, G; Roth, J; Sorg, C | 1 |
| Boyan, G; Meier, T; Williams, L | 1 |
| Belehradek, J; Mir, LM; Pron, G; Tounekti, O | 1 |
| Seymour, GJ; Siller, GM | 1 |
| Awazu, S; Horie, T; Yokoyama, H | 1 |
| Fuchs, T; Häusser, M; Ippen, H; Uter, W | 1 |
| Bredberg, M; Fischer, T; Meijer, C; Widström, L | 1 |
| Bélisle, S; Petit, A | 1 |
| Chen, X; Lange, AB; Orchard, I; Wang, Z | 1 |
| Brudzynski, SM; Munoz, DG | 1 |
| Lidén, C; Wahlberg, JE | 3 |
| Aiken, NR; Galey, WR; Satterlee, JD | 1 |
| Semenza, GL; Wang, GL | 2 |
| Awruch, J; Coll, CT; Frydman, RB; Lemberg, A; Mora, ME | 1 |
| Correia, MA; Liu, H | 1 |
| Alibali, P; Gardner, A; Goldwasser, E | 1 |
| Dotterud, LK; Falk, ES | 1 |
| Bondi, A; Guadagni, M; Manara, GC; Nannini, R; Torresani, C | 1 |
| Horn, EM; Waldrop, TG | 1 |
| Bauer, T; Caro, J; Minchenko, A; Salceda, S | 1 |
| Data, PG; Di Giulio, C; Iezzi, M; Morelli, L | 1 |
| Bannan, P; Gartshore, G; Higley, B; McCulloch, J; Patterson, J | 1 |
| Anderson, JM; Baer, E; Hiltner, A; Lodoen, GA; Wu, YK | 1 |
| Bennett, JL; Day, TA; Pax, RA | 1 |
| Ebert, BL; Firth, JD; Pugh, CW; Ratcliffe, PJ | 1 |
| Acker, H; Fandrey, J; Görlach, A; Holtermann, G | 1 |
| Llesuy, SF; Tomaro, ML | 1 |
| Behta, B; Hojima, Y; Prockop, DJ; Romanic, AM | 1 |
| Biondelli, V; Data, PG; Di Giulio, C; Di Tano, G; Gigante, G; Iezzi, M; Morelli, L | 1 |
| Berke, G; Binah, O; Hoffman, BF; Rosen, D | 1 |
| Christensen, JM; Poulsen, OM; Thomsen, M | 1 |
| Blanchard, KL; Bunn, HF; Fandrey, J; Galson, DL; Goldberg, MA | 1 |
| Karagiannis, CS; Pappelis, AJ | 1 |
| Folly, G; Morvai, V; Szakmáry, E; Tátrai, E; Ungváry, G | 1 |
| Liu, J; Mori, A; Wang, X; Yokoi, I | 1 |
| Adams, M; Breer, H; Schoch, J; Tareilus, E | 1 |
| Ciriello, J; Roder, S | 1 |
| Chang, WC; Huang, JD; Yang, SK | 1 |
| Hattori, Y; Hayashi, Y; Hori, Y; Moriwaki, A | 1 |
| Anestis, DK; Beers, KW; Brown, PI; Nicoll, DW; Rankin, GO | 1 |
| Abe, M; Becker, RP; Deddish, PA; Erdös, EG; Nagae, A; Skidgel, RA | 1 |
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| Arvanitis, D; Arvanitis, N; Chalatsa, I; Frakolaki, E; Kalantzis, ED; Sideris, DC; Tsakou, AC; Vassilacopoulou, D; Vassilaki, N; Vassiliou, AG | 1 |
| Cai, Y; Hong, C; Hu, X; Kang, F; Song, X; Song, Z; Tang, Y; Tian, Y; Zhu, J | 1 |
| Dong, M; Huang, L; Li, J; Tekliye, M; Xia, X; Yin, L; Zhang, Y | 1 |
| Adebiyi, OE; Adedapo, AA; Akinrinde, AS; Emikpe, BO; Jarikre, TA; Ola-Davies, OE; Omobowale, TO; Oyagbemi, AA; Saba, AB | 1 |
| Bai, Y; Bian, X; Chen, J; Du, X; Li, L; Li, Y; Liu, X; Wang, C; Xiao, X; Yin, Y | 1 |
| Gao, L; He, Y; Hou, S; Hou, T; Liu, T; Zheng, J; Zhi, K; Zhu, X | 1 |
| Bruze, M; Glas, B; Hagvall, L; Isaksson, M; Lagrelius, M; Lidén, C; Matura, M; Nyman, G; Stenberg, B; Svedman, C | 1 |
| Chen, A; Duan, Y; Li, F; Liao, R; Tao, L; Xu, Y; Zhang, J | 1 |
| Jeong, H; Kawagishi, H; Kurihara, T; Lee, D; Miwa, Y; Shoda, C; Tsubota, K; Wu, J | 1 |
| Li, L; Li, X; Ma, K; Si, J; Xiao, J; Zhang, L; Zhang, W; Zhang, Y | 1 |
| Dixon, L; Magdaleno, C; Rajasekaran, N; Varadaraj, A | 1 |
| Anésio, A; Bianchi, PC; Carneiro-de-Oliveira, PE; Cruz, FC; Engi, SA; Felipe, JM; Leão, RM; Palombo, P; Planeta, CDS; Yokoyama, TS; Zaniboni, CR | 1 |
| Bertagna, NB; Cruz, FC; Dos Santos, PGC; Fernandes, GJD; Miguel, TT; Queiroz, RM | 1 |
| Baik, TK; Chang, W; Kim, HB; Kim, HS; Lee, JH; Woo, RS; Yoo, JY; Yoo, SY | 1 |
| Chen, Y; Li, S; Tan, B; Yang, Z; Yu, Q; Yuan, D | 1 |
| Fong, TH; Tsui, L | 1 |
| Ibuki, M; Kurihara, T; Lee, D; Miwa, Y; Shinojima, A; Tsubota, K | 1 |
| Chang, YC; Chen, YH; Lai, YH; Lee, PY; Li, CY; Liu, CC; Liu, PL; Liu, YR; Lu, CY; Su, CC; Wang, SC | 1 |
| Cao, Z; Feng, YJ; Hou, ZH; Jiang, F; Shen, QY; Zhou, HY | 1 |
| Baddar, NWAH; Dwaraka, VB; Ponomareva, LV; Thorson, JS; Voss, SR | 1 |
| Dutysheva, EA; Guzhova, IV; Kartsev, VG; Lazarev, VF; Margulis, BA; Mikeladze, MA | 1 |
| Horie, R; Nakano, K; Nakashima, M; Uchimaru, K; Watanabe, M | 1 |
| Ao, S; Leng, H; Liu, Y; Wang, Y; Yang, X; Zhang, H; Zhang, Y | 1 |
| Deng, JJ; Han, XX; Liu, YH; Pan, J; Yu, LM; Zhang, WH; Zhu, LY | 1 |
| Bunikyte, R; Cai, D; Chen, X; Feng, S; Jin, S; Qi, X; Qiao, Y; Wang, Z | 1 |
| Berger, EA; Ebrahim, AS; Guerra, MH; Ibrahim, AS; Singh, LP; Yumnamcha, T | 1 |
| Alves, MP; Alves, PB; Regateiro, FS; Todo-Bom, A | 1 |
| Azi, F; Dong, M; Liu, X; Tekliye, M; Xia, X; Yin, L; Zhang, Y; Zhou, J | 1 |
| Bryngelsson, IL; Klasson, M; Lindberg, M; Persson, A; Särndahl, E; Tuerxun, K; Westberg, H | 1 |
| Chen, RM; Chen, TL; Cherng, YG; Lee, YW; Liu, SH; Yang, ST | 1 |
| Alivand, MR; Emaogolizadeh Gurd Tapeh, B; Mohammadi, A; Solali, S | 1 |
| Coimbra, NC; de Freitas, RL; Luongo, L; Maione, S; Malvestio, RB; Medeiros, AC; Medeiros, P; Negrini-Ferrari, SE; Oliveira-Silva, M; Padovan, CM | 1 |
| Feng, W; Li, Y; Liu, J; Wang, Z; Zhao, G; Zibrila, AI | 1 |
| Mehrotra, S; Pandey, RK; Thakur, N | 1 |
| Feng, J; Hagvall, L; Hedberg, Y; Karma, M; Malmberg, P; Pour, MD | 1 |
| Knyazev, EN; Paul, SY; Tonevitsky, AG | 1 |
| Barman, HK; Chakrapani, V; Mohapatra, SD; Mondal, S; Murmu, B; Patra, K; Soren, MM; Swain, RK | 1 |
| Chen, M; Chi, Z; Tao, Q; Zhang, C | 1 |
| Cheng, J; Gong, X; Li, S; Luo, Y; Wang, Y; Zhang, K | 1 |
| Chang, X; Gao, XX; Hu, ZL; Li, CQ; Li, HY; Li, YY; Liu, CH; Zhai, Y; Zhang, YY | 1 |
| Marzocco, S; Pecoraro, M; Popolo, A | 1 |
| Feng, Q; Hu, X; Lai, Z; Lu, L; Lu, P; Wang, S; Wang, W; Wang, Y; Weng, J; Yang, X; Zhang, L; Zhou, M | 1 |
| Buehner, T; Deppe, L; Dick, BH; Joachim, SC; Mueller-Buehl, AM; Peters, L; Pfarrer, C | 1 |
| Gao, Q; Luo, Z; Xu, J; Xu, W; Zhang, H; Zhang, J; Zhang, Y; Zhou, S | 1 |
| Barboni, B; Berardinelli, P; Citeroni, MR; Delle Monache, S; Di Mattia, M; Mauro, A; Peserico, A; Pulcini, F; Russo, V; Turriani, M | 1 |
| Dhiman, N; Koppal, VV; Kumar, V; Melavanki, R; Patil, NR; Singh, D | 1 |
| Kale, V; Pendse, S; Vaidya, A | 1 |
| Ge, X; He, C; Huang, C; Liu, S; Yang, C; Yang, S; Zhang, X | 1 |
| Jiang, L; Jiang, T; Ni, S; Tan, X; Tao, F; Wang, Z; Wei, C; Xiang, P; Xiao, T; Yin, X | 1 |
| Chen, M; Chi, Z; Li, Q; Liu, YW; Mao, J; Min, S; Zhang, C | 1 |
| Chen, YS; Hsieh, ST; Wang, YC | 1 |
| Çoban, TA; Ersoy, A; Mammadov, R; Süleyman, B; Tanoğlu, C; Yazıcı, GN | 1 |
| Delbandi, AA; Falak, R; Kardar, GA; Rashidi, N; Sadri, M | 1 |
| Hou, Y; Jiang, S; Meng, X; Wang, X; Xie, N; Zhang, Y | 1 |
| Liu, Y; Liu, YC; Qiao, FX; Sun, MX; Wang, HL; Xu, ZR; Zhao, SC | 1 |
| Li, M; Liu, F | 1 |
| Karthikeyan, NS; Kritika, S; Mahalaxmi, S; Ravichandran, C; Sarath Kumar, K; Sujatha, V | 1 |
| F Abcouwer, S; Kaur, B; Miglioranza Scavuzzi, B; N Zacks, D | 1 |
18 review(s) available for cobaltous chloride and cobalt
| Article | Year |
|---|---|
Antimutagenicity in cultured mammalian cells.
Topics: Animals; Antimutagenic Agents; Cells, Cultured; Cobalt; Genetic Techniques; Plants | 1992 |
Diet as a source of inhibitors of mutagenesis.
Topics: Animals; Cobalt; Diet; Humans; Mutagens; Plant Extracts; Selenium; Vegetables; Vitamins | 1990 |
Contact dermatitis caused by airborne agents. A review and case reports.
Topics: Adult; Aged; Air Pollutants; Captan; Cobalt; Dermatitis, Contact; Dermatitis, Occupational; Detergents; Eczema; Erythema; Female; Humans; Male; Middle Aged; Perfume; Pyrithioxin; Quinolines; Thiram; Turpentine | 1986 |
Corticotectal circuit in the cat: a functional analysis of the lateral geniculate nucleus layers of origin.
Topics: Animals; Cats; Cobalt; Electrophysiology; Female; Geniculate Bodies; Male; Neural Pathways; Photic Stimulation; Superior Colliculi; Tectum Mesencephali; Visual Cortex | 1988 |
Antimutagenesis by factors affecting DNA repair in bacteria.
Topics: Bacteria; Benzaldehydes; Cobalt; DNA Repair; Escherichia coli; Mutation | 1988 |
Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cell-Free System; Cobalt; Cytosol; Dicarbethoxydihydrocollidine; Heme; Hemin; Immunodiffusion; Leucine; Liver; Mitochondria, Liver; Molecular Weight; Protoporphyrins; Rabbits; Rats; Tryptophan Oxygenase | 1981 |
Cis elements that regulate the erythropoietin gene.
Topics: Animals; Cell Line; Cobalt; Erythropoietin; Exons; Gene Expression Regulation; Humans; Mice; Oxygen; Regulatory Sequences, Nucleic Acid; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transfection | 1994 |
Imaging the mitochondrial permeability transition pore in intact cells.
Topics: Animals; Cell Membrane Permeability; Cobalt; Cyclosporine; Fluoresceins; Fluorescent Dyes; Humans; Microscopy, Confocal; Mitochondria | 1998 |
[Studies on the syntheses of the hypermodified nucleosides of phenylalanine transfer ribonucleic acids].
Topics: Amino Acids; Carbohydrate Conformation; Carbonates; Chemistry, Organic; Cobalt; Dioxanes; Glycols; Nucleosides; Purine Nucleosides; RNA, Transfer, Phe | 2003 |
Endothelin-2/vasoactive intestinal contractor: regulation of expression via reactive oxygen species induced by CoCl2, and Biological activities including neurite outgrowth in PC12 cells.
Topics: Animals; Cobalt; Endothelin-2; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Neurites; Neurons; PC12 Cells; Peptides; Rats; Reactive Oxygen Species; Ultrasonography | 2006 |
Hypoxia and the HIF system in kidney disease.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cobalt; Erythropoietin; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Kidney; Kidney Diseases; Oxygen; Signal Transduction | 2007 |
Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis.
Topics: Anemia; Animals; Cobalt; Doping in Sports; Erythropoiesis; GATA Transcription Factors; Glycine; Hematinics; Humans; Hydroxybenzoates; Hypoxia-Inducible Factor 1; Quinolones; Small Molecule Libraries; Substance Abuse Detection | 2012 |
Role of rice heme oxygenase in lateral root formation.
Topics: Cobalt; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Nitric Oxide; Oryza; Plant Roots | 2013 |
Intolerability of cobalt salt as erythropoietic agent.
Topics: Anemia; Animals; Cobalt; Erythropoiesis; Hematinics; Humans | 2014 |
The effect of cobalt on the human eye.
Topics: Arthroplasty, Replacement, Hip; Cobalt; Environmental Exposure; Female; Humans; Male; Metal-on-Metal Joint Prostheses; Optic Nerve Diseases; Retinal Diseases; Vision Disorders | 2015 |
Elicitation threshold of cobalt chloride: analysis of patch test dose-response studies.
Topics: Cobalt; Dermatitis, Allergic Contact; Humans; Patch Tests; Skin Irritancy Tests; Skin Tests | 2016 |
The use of cobalt chloride as a chemical hypoxia model.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Oxidation-Reduction; Oxygen | 2019 |
Mechanisms Leading to Differential Hypoxia-Inducible Factor Signaling in the Diabetic Kidney: Modulation by SGLT2 Inhibitors and Hypoxia Mimetics.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cobalt; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Erythropoiesis; Fibrosis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Kidney; Oxidative Stress; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors | 2021 |
6 trial(s) available for cobaltous chloride and cobalt
| Article | Year |
|---|---|
A short-term cross-over study on oral administration of soluble and insoluble cobalt compounds: sex differences in biological levels.
Topics: Adult; Cobalt; Female; Humans; Intestinal Absorption; Male; Oxides; Reference Values; Sex Factors; Solubility | 1993 |
Hypersensitivity to metals in orthodontics.
Topics: Adolescent; Adult; Child; Chlorides; Cobalt; Female; Humans; Hypersensitivity; Immunization; Iron; Male; Manganese Compounds; Molybdenum; Nickel; Orthodontic Appliances; Patch Tests; Potassium Dichromate; Sex Factors; Titanium | 2004 |
Cross-reactivity between nickel and palladium demonstrated by systemic administration of nickel.
Topics: Administration, Oral; Adult; Allergens; Cobalt; Cross Reactions; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female; Humans; Irritants; Middle Aged; Nickel; Palladium; Patch Tests; Spectrophotometry, Atomic | 2005 |
31-day study of cobalt(II) chloride ingestion in humans: pharmacokinetics and clinical effects.
Topics: Administration, Oral; Adult; Aged; Cobalt; Dietary Supplements; Drug Administration Schedule; Erythrocytes; Female; Half-Life; Humans; Lymphocyte Activation; Male; Middle Aged; Young Adult | 2013 |
Cobalt accumulation in horses following repeated administration of cobalt chloride.
Topics: Animals; Cobalt; Creatinine; Female; Horses; New South Wales; Plasma; Sports | 2019 |
Topics: 3-Hydroxybutyric Acid; Acetazolamide; Acrylates; Administration, Intravenous; Adolescent; Adult; Aerosols; Afghanistan; Aflatoxin M1; Agaricales; Aged; Aged, 80 and over; Agricultural Irrigation; Air Pollutants; alpha-L-Fucosidase; Amino Acid Sequence; Androgen Antagonists; Animals; Antibodies, Bacterial; Antigens, Bacterial; Antineoplastic Agents; Antioxidants; Apoptosis; Artifacts; Autophagy; B7-H1 Antigen; Bacterial Proteins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Bile; Bioelectric Energy Sources; Biosensing Techniques; Body Mass Index; Brain; Brazil; Breast Neoplasms; Bufo arenarum; Burkholderia; C-Reactive Protein; Cadmium; Carbon Compounds, Inorganic; Carbon-13 Magnetic Resonance Spectroscopy; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Carcinoma, Transitional Cell; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Count; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Characiformes; Child; China; Cities; Cobalt; Colonic Neoplasms; Copper Sulfate; Cross-Sectional Studies; Cyclin-Dependent Kinase Inhibitor p16; Cytokines; Deoxycytidine; Diagnosis, Differential; Digestive System; Dihydroxyphenylalanine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Barcoding, Taxonomic; DNA, Bacterial; Dose-Response Relationship, Drug; Down-Regulation; Edetic Acid; Electrochemical Techniques; Electrodes; Embolization, Therapeutic; Embryo, Nonmammalian; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Fatty Acids; Feces; Female; Follow-Up Studies; Food Contamination; Forkhead Box Protein M1; Fresh Water; Fungicides, Industrial; Gallium Isotopes; Gallium Radioisotopes; Gastrectomy; Gastric Bypass; Gastric Outlet Obstruction; Gastroplasty; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Bacterial; Genetic Markers; Genome, Bacterial; Genome, Mitochondrial; Glioma; Glycogen Synthase Kinase 3 beta; Goats; Gonads; Guatemala; Halomonadaceae; HEK293 Cells; Helicobacter Infections; Helicobacter pylori; Hepacivirus; Histone-Lysine N-Methyltransferase; Hormones; Humans; Hydroxybutyrate Dehydrogenase; Hypersplenism; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Iran; Japan; Lactuca; Laparoscopy; Larva; Ligands; Liver Neoplasms; Lymphocyte Activation; Macrophages; Malaria; Male; Mercury; Metabolic Syndrome; Metals, Heavy; Mice; Middle Aged; Milk, Human; Mitochondria; Models, Molecular; Molecular Structure; Mothers; Multilocus Sequence Typing; Muscles; Mutation; Nanocomposites; Nanotubes, Carbon; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Cells, Circulating; Neoplastic Stem Cells; Neuroimaging; Nitriles; Nitrogen Isotopes; Non-alcoholic Fatty Liver Disease; Nuclear Magnetic Resonance, Biomolecular; Obesity; Obesity, Morbid; Oligopeptides; Oxidation-Reduction; Pancreatic Neoplasms; Particle Size; Particulate Matter; Pepsinogen A; Pesticides; Pharmacogenetics; Phosphatidylinositol 3-Kinases; Phospholipids; Phylogeny; Plasmodium ovale; Plasmodium vivax; Platelet Count; Polyhydroxyalkanoates; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postoperative Complications; Pregnancy; Prevalence; Prognosis; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Domains; Proto-Oncogene Proteins c-akt; Proton Magnetic Resonance Spectroscopy; Pseudogenes; PTEN Phosphohydrolase; Pyrazoles; Pyrimidines; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Rats, Long-Evans; Rats, Sprague-Dawley; RAW 264.7 Cells; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptor, Notch3; Receptors, G-Protein-Coupled; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Repressor Proteins; Resveratrol; Retrospective Studies; Risk Assessment; Risk Factors; RNA, Messenger; RNA, Ribosomal, 16S; Salinity; Salvage Therapy; Seasons; Sequence Analysis, DNA; Seroepidemiologic Studies; Signal Transduction; Skin; Snails; Soluble Guanylyl Cyclase; Solutions; Spain; Species Specificity; Spheroids, Cellular; Splenic Artery; Stomach Neoplasms; Streptococcus pneumoniae; Structure-Activity Relationship; Sulfonamides; Sunlight; Surface Properties; Surgical Instruments; Surgical Wound Infection; Survival Rate; Tetrahydrouridine; Thinness; Thrombocytopenia; Tissue Distribution; Titanium; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Tumor Microenvironment; Tumor Necrosis Factor-alpha; Turkey; Ubiquinone; Urologic Neoplasms; Viral Envelope Proteins; Wastewater; Water Pollutants, Chemical; Weather; Wnt Signaling Pathway; Xenograft Model Antitumor Assays; Young Adult | 2007 |
1772 other study(ies) available for cobaltous chloride and cobalt
| Article | Year |
|---|---|
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ketones; Liver; Male; Methylcholanthrene; Mirex; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Sprague-Dawley; Taurolithocholic Acid | 1992 |
Demonstration of ouabain-sensitive, potassium-dependent p-nitrophenylphosphatase activity in the rat cardiac muscle by cobalt-based cytochemistry.
Topics: 4-Nitrophenylphosphatase; Animals; Cobalt; Endothelium, Vascular; Histocytochemistry; Male; Myocardium; Ouabain; Rats; Rats, Wistar; Sarcolemma; Sodium-Potassium-Exchanging ATPase | 1992 |
Catecholamine secretion from adrenal chromaffin cells of the toad (Caudiverbera caudiverbera): effect of monensin.
Topics: Acetylcholine; Adenosine Triphosphate; Adrenal Glands; Animals; Anura; Calcium; Catecholamines; Chromaffin System; Cobalt; Monensin; Nifedipine; Potassium; Sodium; Tetrodotoxin | 1992 |
Nonlinear mechanical responses of mouse cochlear hair bundles.
Topics: Animals; Calcium; Cells, Cultured; Cobalt; Elasticity; Electrophysiology; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Mathematics; Membrane Potentials; Mice; Microelectrodes; Models, Biological; Quaternary Ammonium Compounds | 1992 |
Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor.
Topics: Animals; Cell Survival; Cells, Cultured; Cobalt; Gene Expression Regulation, Enzymologic; Glucagon; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Oxygen; Partial Pressure; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger | 1992 |
Comparison of minimally invasive methods of parietal cell vagotomy in a porcine model.
Topics: Animals; Benzalkonium Compounds; Cobalt; Gastric Mucosa; Gastroscopy; Laparoscopy; Laser Therapy; Swine; Vagotomy, Proximal Gastric | 1992 |
Bilirubin production and conjugation from newly formed heme in isolated rat hepatocytes.
Topics: Aminolevulinic Acid; Animals; Bile Pigments; Bilirubin; Cells, Cultured; Cobalt; Heme; Hemin; Kinetics; Liver; Male; Metalloporphyrins; Protoporphyrins; Rats; Rats, Sprague-Dawley | 1992 |
Carboxypeptidase M in brain and peripheral nerves.
Topics: 3-Mercaptopropionic Acid; Animals; Blotting, Northern; Brain; Brain Chemistry; Cobalt; Dogs; GPI-Linked Proteins; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunohistochemistry; Lysine Carboxypeptidase; Metalloendopeptidases; Myelin Sheath; Papio; Peripheral Nerves; Precipitin Tests; RNA, Messenger; Schwann Cells | 1992 |
Analgesic actions of local anesthetics and cobalt chloride in the rat brain stem.
Topics: Analgesics; Anesthetics, Local; Animals; Brain Stem; Cobalt; Female; Pain Measurement; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1992 |
Skin reactivity to metallic cobalt in patients with a positive patch test to cobalt chloride.
Topics: Cobalt; Dermatitis, Allergic Contact; False Positive Reactions; Female; Humans; Male; Patch Tests | 1992 |
Differences of draining lymph node cell proliferation among mice, rats and guinea pigs following exposure to metal allergens.
Topics: Allergens; Animals; Cell Count; Cell Division; Cells, Cultured; Cobalt; Dermatitis, Allergic Contact; Female; Ferric Compounds; Guinea Pigs; Lymph; Lymph Nodes; Metals; Mice; Mice, Inbred CBA; Nickel; Organ Size; Potassium Dichromate; Rabbits; Rats; Rats, Inbred F344; Species Specificity; Thymidine; Tritium | 1992 |
[Experimental atherosclerosis and its correction with Co-35].
Topics: Animals; Arteriosclerosis; Cholesterol; Cobalt; Fatty Acids; Hemostasis; Lipoproteins, LDL; Lysophosphatidylcholines; Phosphatidylcholines; Phosphatidylethanolamines; Rabbits; Sphingomyelins | 1992 |
Caffeine inhibits depolarization-activated outward currents in rat ventricular myocytes.
Topics: Action Potentials; Animals; Caffeine; Calcium; Cobalt; Egtazic Acid; Electrophysiology; Heart; Heart Ventricles; In Vitro Techniques; Myocardium; Potassium; Rats; Ryanodine | 1992 |
Role of the rostral ventrolateral medulla in the generation of synchronized sympathetic rhythmicities in the rat.
Topics: Animals; Blood Pressure; Brain Stem; Chemoreceptor Cells; Cobalt; Electric Stimulation; Kainic Acid; Magnesium Chloride; Male; Medulla Oblongata; Microinjections; Phrenic Nerve; Pressoreceptors; Rats; Rats, Wistar; Sympathetic Nervous System; Synapses; Vagotomy | 1992 |
Detection of contact sensitivity of metal salts using the murine local lymph node assay.
Topics: Animals; Cell Division; Cobalt; Dermatitis, Contact; Dimethyl Sulfoxide; Ear, External; Ethanol; Female; Ferrous Compounds; Lymph Nodes; Lymphocyte Activation; Metals; Mice; Pharmaceutical Vehicles; Potassium Dichromate; Skin; Skin Tests; Sulfates; Zinc; Zinc Sulfate | 1992 |
[Serotonin-induced changes in the responses of electrically stimulated neuronal membrane of the mollusk].
Topics: Action Potentials; Animals; Calcium; Cobalt; Helix, Snails; Membrane Potentials; Neuronal Plasticity; Potassium Channels; Quinine; Serotonin | 1992 |
Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Cell Nucleus; Cobalt; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenobarbital; Polymerase Chain Reaction; Pyrazoles; RNA, Messenger; Steroid Hydroxylases | 1992 |
The role of thiol oxidation in Cobalt(II)-induced toxicity in hamster lung.
Topics: Animals; Carmustine; Cell Death; Cobalt; Cricetinae; Female; Glutathione; Glutathione Reductase; Hydrogen Peroxide; In Vitro Techniques; Lung; Male; Mesocricetus; Oxidation-Reduction; Pentose Phosphate Pathway; Peroxides; Sulfhydryl Compounds; tert-Butylhydroperoxide | 1992 |
In vitro and in vivo inhibition of N-acetyl-L-aspartyl-L-glutamate catabolism by N-acylated L-glutamate analogs.
Topics: Acetylation; Animals; Cobalt; Dipeptides; Glutamates; Hydrolysis; In Vitro Techniques; Male; Peptides; Rats; Rats, Inbred Strains; Zinc | 1992 |
Cobaltous ion inhibition of lipid peroxidation in biological membranes.
Topics: Animals; Cobalt; Edetic Acid; Erythrocyte Membrane; Humans; Linoleic Acids; Lipid Peroxidation; Liposomes; Membrane Lipids; Micelles; Microsomes, Liver; Phosphatidylethanolamines; Phosphatidylserines; Rats | 1992 |
Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.
Topics: Amino Acid Sequence; Chlorides; Chromatography, Gel; Cloning, Molecular; Cobalt; DNA Nucleotidyltransferases; HIV-1; Hydrogen-Ion Concentration; Integrases; Kinetics; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry; Thermodynamics; Zinc; Zinc Compounds; Zinc Fingers | 1992 |
Lung injury induced by paraquat, hyperoxia and cobalt chloride: effects of ambroxol.
Topics: Ambroxol; Analysis of Variance; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Cobalt; L-Lactate Dehydrogenase; Lung; Male; Organ Size; Oxygen; Paraquat; Rats; Rats, Inbred Strains | 1992 |
Rabbit lung after combined exposure to soluble cobalt and trivalent chromium.
Topics: Animals; Chromium; Chromium Compounds; Cobalt; Drug Synergism; Lung; Macrophages, Alveolar; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Nitrates; Phospholipids; Pulmonary Alveoli; Rabbits | 1992 |
Functional influence of interlaminar connections in the hamster's superior colliculus.
Topics: Animals; Cobalt; Cricetinae; Horseradish Peroxidase; Injections; Lidocaine; Neural Pathways; Neurons; Superior Colliculi; Vision, Ocular | 1992 |
A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and CO.
Topics: Aldehyde-Lyases; Carbon Monoxide; Chlorophyta; Chromatography, Gel; Chromatography, Ion Exchange; Cobalt; Electron Probe Microanalysis; Hydrocarbons; Kinetics; Microsomes; Porphyrins; Protein Binding; Stearic Acids | 1992 |
The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances.
Topics: Animals; Antipyrine; Cobalt; Ethosuximide; Liver; Male; Mixed Function Oxygenases; Proadifen; Quinidine; Rats; Rats, Inbred Strains; Succinimides; Theophylline | 1992 |
Differences in extracellular calcium involvement mediating the secretion of gonadotropin and growth hormone stimulated by two closely related endogenous GnRH peptides in goldfish pituitary cells.
Topics: Animals; Calcium; Cobalt; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Growth Hormone; Male; Pituitary Gland | 1992 |
Adenosine modulation of potassium currents in preganglionic nerve terminals of avian ciliary ganglia.
Topics: Adenosine; Animals; Autonomic Fibers, Preganglionic; Calcium; Cesium; Chickens; Chlorides; Cobalt; Ganglia, Parasympathetic; Ion Channel Gating; Potassium; Potassium Channels; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
[The effect of the addition of Co2+ ions on the osmolarity and concentration of Na+, K+ and Ca2+ ions in the blood serum of rats].
Topics: Animals; Calcium; Cobalt; Dehydration; Female; Ions; Male; Osmolar Concentration; Potassium; Rats; Rats, Inbred Strains; Sodium; Vasopressins | 1991 |
Loss of Co2+ sensitivity of monkey brain cytosolic neutral alpha-D-mannosidase by cyclic AMP dependent phosphorylation.
Topics: alpha-Mannosidase; Aminopeptidases; Animals; Brain; Cobalt; Cyclic AMP; Cytosol; Hydrogen-Ion Concentration; Kinetics; Macaca radiata; Mannosidases; Phosphorylation; Protein Kinases | 1991 |
Calcium homeostasis in bovine somatotrophs: calcium oscillations and calcium regulation by growth hormone-releasing hormone and somatostatin.
Topics: Animals; Calcium; Calcium Channels; Cattle; Cobalt; Colforsin; Drug Interactions; Fura-2; Growth Hormone-Releasing Hormone; Homeostasis; Male; Oscillometry; Pituitary Gland, Anterior; Somatostatin; Spectrometry, Fluorescence | 1991 |
Teratogenicity of cobalt chloride in Xenopus laevis, assayed by the FETAX procedure.
Topics: Abnormalities, Drug-Induced; Animals; Cobalt; Embryo, Nonmammalian; Xenopus laevis | 1991 |
Inhibitory effects of cobalt chloride and cinnamaldehyde on 5-azacytidine-induced digital malformations in rats.
Topics: Abnormalities, Drug-Induced; Acrolein; Aldehydes; Analysis of Variance; Animals; Azacitidine; Body Weight; Cobalt; Female; Fetal Death; Humans; Pregnancy; Rats; Rats, Inbred Strains; Toes | 1990 |
Stable [57Co]-bleomycin complex with a very high specific radioactivity for use at very low concentrations.
Topics: Animals; Bleomycin; Cell Line; Cell Survival; Chromatography, Gel; Clone Cells; Cobalt; Cobalt Radioisotopes; Electric Stimulation; Kinetics | 1990 |
K(+)-evoked depolarization stimulates cyclic AMP accumulation in photoreceptor-enriched retinal cell cultures: role of calcium influx through dihydropyridine-sensitive calcium channels.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cadmium; Cadmium Chloride; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Cobalt; Cyclic AMP; Kinetics; Magnesium Chloride; Membrane Potentials; Nifedipine; Photoreceptor Cells; Potassium; Retina; Retinal Ganglion Cells | 1991 |
Morphophysiology of synaptic transmission between type I hair cells and vestibular primary afferents. An intracellular study employing horseradish peroxidase in the lizard, Calotes versicolor.
Topics: Action Potentials; Afferent Pathways; Animals; Axonal Transport; Cobalt; Evoked Potentials; Hair Cells, Auditory; Horseradish Peroxidase; Lizards; Microscopy, Electron; Nerve Fibers; Nerve Fibers, Myelinated; Synapses; Synaptic Transmission; Tetrodotoxin; Vestibule, Labyrinth | 1991 |
Chromosomal aberrations induced by cobaltous chloride in mice in vivo.
Topics: Administration, Oral; Analysis of Variance; Animals; Bone Marrow; Chromosome Aberrations; Cobalt; Dose-Response Relationship, Drug; Male; Mice; Mutagens | 1991 |
Ion channels of glucose-responsive and -unresponsive beta-cells.
Topics: Animals; Cobalt; Electrophysiology; Glucose; Glyburide; Hemolytic Plaque Technique; In Vitro Techniques; Ion Channels; Islets of Langerhans; Male; Membrane Potentials; Potassium Channels; Potassium Chloride; Rats; Rats, Inbred Strains; Sodium Channels; Tolbutamide | 1991 |
Heme oxygenase induction by CoCl2, Co-protoporphyrin IX, phenylhydrazine, and diamide: evidence for oxidative stress involvement.
Topics: Allopurinol; Animals; Antioxidants; Cobalt; Cycloheximide; Dactinomycin; Diamide; Enzyme Induction; Female; Heme Oxygenase (Decyclizing); Kinetics; Liver; Phenylhydrazines; Protoporphyrins; Rats; Rats, Inbred Strains; Vitamin E | 1991 |
Specificity of mono- and divalent salt transduction mechanisms in frog gustation evidenced by cobalt chloride treatment.
Topics: Afferent Pathways; Animals; Calcium Chloride; Cobalt; Female; Glossopharyngeal Nerve; Magnesium Chloride; Male; Mechanoreceptors; Membrane Potentials; Potassium Chloride; Rana pipiens; Sodium Chloride; Taste | 1991 |
Angiotensin II-induced increase in slowly exchanging 45Ca2+ in relation to contractile responses of rat and guinea-pig aorta.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Chlorpromazine; Cobalt; Guinea Pigs; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Saralasin | 1991 |
Role of caudal ventrolateral medulla in reflex and central control of airway caliber.
Topics: Airway Resistance; Animals; Atropine; Bronchoconstriction; Cobalt; Diencephalon; Dogs; Electric Stimulation; Ibotenic Acid; Medulla Oblongata; Muscle Contraction; Muscle, Smooth; Reflex; Sciatic Nerve | 1991 |
Cyanide sensitive and insensitive bioenergetics in a clonal neuroblastoma x glioma hybrid cell line.
Topics: Adenosine Triphosphate; Animals; Clone Cells; Cobalt; Deoxyglucose; Glioma; Hybrid Cells; Iodoacetates; Iodoacetic Acid; Kinetics; Leucine; Neuroblastoma; Neurons; Protein Biosynthesis; Sodium Cyanide | 1991 |
Cytotoxic effects of cobalt chloride on mouse bone marrow cells in vivo.
Topics: Administration, Oral; Animals; Bone Marrow; Chromosome Aberrations; Cobalt; Dose-Response Relationship, Drug; Mice | 1991 |
Paths of information flow through visual cortex.
Topics: Animals; Calcium Channels; Cats; Cobalt; Photic Stimulation; Synapses; Visual Cortex; Visual Perception | 1991 |
Chronic cobalt causes hypertrophy of glomus cells in the rat carotid body.
Topics: Animals; Carotid Body; Cobalt; Erythropoiesis; Hematocrit; Hypertrophy; Male; Rats; Rats, Inbred Strains | 1991 |
Status of hepatic heme and heme oxygenase during Plasmodium yoelii nigeriensis infection in mice.
Topics: Administration, Oral; Animals; Cell Fractionation; Chloroquine; Cobalt; Heme; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Liver; Malaria; Mice; Plasmodium yoelii | 1991 |
The whole-body withdrawal response of Lymnaea stagnalis. I. Identification of central motoneurones and muscles.
Topics: Animals; Brain; Cobalt; Electrophysiology; Escape Reaction; Ganglia; Isoquinolines; Lymnaea; Motor Neurons; Muscles | 1991 |
Mutagenicity of various chemicals including nickel and cobalt compounds in cultured mouse FM3A cells.
Topics: Acetates; Acetic Acid; Animals; Carbolines; Cell Line; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; In Vitro Techniques; Mice; Mice, Inbred C3H; Mitomycin; Mutagenicity Tests; Mutagens; Nickel; Sterigmatocystin; X-Rays | 1991 |
Comparative efficacy of chlorophyllin in reducing cytotoxicity of some heavy metals.
Topics: Animals; Cesium; Chlorides; Chlorophyllides; Chromosome Aberrations; Cobalt; Mercuric Chloride; Metals; Mice; Mutagenicity Tests | 1991 |
Co-regulation of heme oxygenase and erythropoietin genes.
Topics: Animals; Base Sequence; Blotting, Northern; Cobalt; Erythropoietin; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Kidney; Kinetics; Male; Molecular Sequence Data; Polydeoxyribonucleotides; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1991 |
Differentiation of a stem cell line toward a neuronal phenotype.
Topics: Animals; Cell Aggregation; Cell Differentiation; Cell Division; Cell Line; Cobalt; Electrophysiology; Evoked Potentials; Immunoenzyme Techniques; Membrane Potentials; Neurons; Phenotype; Phosphopyruvate Hydratase; Stem Cells; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Tretinoin | 1991 |
Cobalt poisoning in a 6-year-old.
Topics: Beverages; Child; Cobalt; Humans; Male; Neutropenia; Play and Playthings; Vomiting | 1990 |
Somatostatin increases voltage-dependent potassium currents in rat somatotrophs.
Topics: 4-Aminopyridine; Animals; Cell Membrane; Cells, Cultured; Cobalt; Electrophysiology; Evoked Potentials; Kinetics; Male; Pituitary Gland; Potassium Channels; Rats; Rats, Inbred Strains; Somatostatin; Tetraethylammonium; Tetraethylammonium Compounds | 1990 |
Role of hepatocellular regeneration in CCl4 autoprotection.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cobalt; Cytochrome P-450 Enzyme System; DNA; Liver; Liver Regeneration; Male; Microsomes, Liver; Mitosis; Rats; Rats, Inbred Strains | 1991 |
Simple monochromatic refractometer for trans-epidermal water loss (TEWL).
Topics: Adult; Body Water; Cobalt; Female; Humans; Male; Refractometry; Skin; Skin Diseases; Skin Physiological Phenomena; Water Loss, Insensible | 1990 |
Ultrastructural organization of receptor cell axons in frog olfactory nerve.
Topics: Animals; Axons; Cobalt; Epithelium; Microscopy, Electron; Olfactory Bulb; Olfactory Nerve; Rana pipiens; Sensory Receptor Cells | 1990 |
Spontaneous rhythmic activity in the intermediolateral cell nucleus of the neonate rat thoracolumbar spinal cord in vitro.
Topics: Action Potentials; Animals; Animals, Newborn; Cobalt; Electric Stimulation; Electrophysiology; In Vitro Techniques; Membrane Potentials; Neurons; Rats; Rats, Inbred Strains; Spinal Cord; Tetraethylammonium; Tetraethylammonium Compounds | 1990 |
Relationship between intracellular pH (pHi) and calcium (Cai2+) in avian heart fibroblasts.
Topics: Ammonium Chloride; Animals; Calcium; Chick Embryo; Cobalt; Egtazic Acid; Fibroblasts; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Lanthanum; Methylamines; Myocardium | 1990 |
[Protective effect of ascorbic acid in cells of people exposed to cobalt chloride].
Topics: 4-Nitroquinoline-1-oxide; Ascorbic Acid; Cells, Cultured; Cobalt; DNA Damage; DNA Repair; Humans; Lymphocytes; Mutagens; Occupational Exposure; Vaccinia virus | 1990 |
Lanthanum inhibits steady-state turnover of the sarcoplasmic reticulum calcium ATPase by replacing magnesium as the catalytic ion.
Topics: Adenosine Triphosphate; Animals; Calcimycin; Calcium Chloride; Calcium-Transporting ATPases; Cobalt; Egtazic Acid; Kinetics; Lanthanum; Magnesium; Muscles; Phosphorylation; Protein Binding; Rabbits; Sarcoplasmic Reticulum | 1990 |
Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded tetracycline resistance protein.
Topics: Biological Transport; Cations, Divalent; Cell Membrane; Cobalt; DNA Transposable Elements; Escherichia coli; Kinetics; Magnesium; Models, Biological; Plasmids; R Factors; Repressor Proteins; Tetracycline; Tetracycline Resistance; Transcription Factors | 1990 |
Powerful anti-sperm motility action of cobaltous ion and its recovery by a sulfhydryl compound.
Topics: Cobalt; Cysteine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Male; Semen; Sperm Motility | 1990 |
Chronic diabetes mellitus prolongs action potential duration of rat ventricular muscles: circumstantial evidence for impaired Ca2+ channel.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cobalt; Diabetes Mellitus, Experimental; Electric Stimulation; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Rats; Rats, Inbred Strains; Ryanodine | 1990 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured | 1990 |
[A reversible change in the osmolarity and distribution of blood serum protein fractions in rats under the influence of cobalt ions].
Topics: Animals; Blood Proteins; Chlorides; Chromatography, High Pressure Liquid; Cobalt; Edetic Acid; Female; In Vitro Techniques; Male; Manganese; Manganese Compounds; Osmolar Concentration; Osmotic Pressure; Rats; Rats, Inbred Strains | 1990 |
Electrogenic pump (Na+/K(+)-ATPase) activity in rat optic nerve.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cobalt; Electric Stimulation; In Vitro Techniques; Lithium; Optic Nerve; Ouabain; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Strophanthidin; Tetraethylammonium; Tetraethylammonium Compounds | 1990 |
Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney.
Topics: Animals; Arginine; Cobalt; DNA; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Nucleic Acid Hybridization; Plasmids; Protoporphyrins; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1990 |
Antimutagenic action of cobaltous chloride on radiation-induced mutations in cultured Chinese hamster cells.
Topics: Animals; Azaguanine; Cell Line; Cell Survival; Cobalt; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Gamma Rays; Lung; Mutagens; Mutation; Ultraviolet Rays | 1990 |
Heme oxygenase-2 mRNA: developmental expression in the rat liver and response to cobalt chloride.
Topics: Animals; Cobalt; Enzyme Induction; Heme Oxygenase (Decyclizing); Isoenzymes; Liver; Microsomes, Liver; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1990 |
Seizure elicited by VPL stimulation in cobalt induced epilepsy model.
Topics: Afferent Pathways; Animals; Cats; Chronic Disease; Cobalt; Convulsants; Electroencephalography; Epilepsy; Evoked Potentials, Somatosensory; Hindlimb; Kindling, Neurologic; Somatosensory Cortex; Thalamic Nuclei | 1990 |
Biophysical properties of hypoglossal neurons in vitro: intracellular studies in adult and neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Brain Stem; Cobalt; Electrodes; Histocytochemistry; Horseradish Peroxidase; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Motor Neurons; Plethysmography, Impedance; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Wheat Germ Agglutinins | 1990 |
Effects of ischemia and reperfusion on protein synthesis in livers with different glutathione levels.
Topics: Animals; Cobalt; Fasting; Glutathione; Ischemia; Leucine; Liver; Liver Glycogen; Male; Maleates; Protein Biosynthesis; Rats; Rats, Inbred Strains; Reperfusion Injury | 1990 |
Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel.
Topics: Aldosterone; Angiotensin II; Animals; Biological Transport, Active; Calcium; Cobalt; Female; In Vitro Techniques; Inositol Phosphates; Kinetics; Male; Nickel; Rats; Rats, Inbred Strains; Zona Glomerulosa | 1990 |
Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.
Topics: Chloroquine; Cobalt; Deferoxamine; Heptanoates; Humans; In Vitro Techniques; Luciferases; Monensin; Phagocytosis; Polylysine; Porphobilinogen Synthase; Receptors, Transferrin; Transferrin; Transformation, Genetic; Tumor Cells, Cultured | 1990 |
Chemical degeneration of intestinal nerves.
Topics: Animals; Axons; Cobalt; Cytoplasmic Granules; Dogs; Jejunum; Lysosomes; Male; Microscopy, Electron; Myenteric Plexus; Nerve Degeneration; Nerve Fibers; Vacuoles; Vasoactive Intestinal Peptide | 1990 |
Induction of hepatic metallothionein by intraperitoneal metal injection: an associated inflammatory response.
Topics: Animals; Cells, Cultured; Chick Embryo; Chickens; Chlorides; Chromium; Chromium Compounds; Cobalt; Ferric Compounds; Fibroblasts; Inflammation; Injections, Intraperitoneal; Kinetics; Liver; Male; Manganese Compounds; Manganese Poisoning; Metallothionein; Metals; Nickel | 1990 |
Reflex splanchnic nerve stimulation increases levels of carboxypeptidase E mRNA and enzymatic activity in the rat adrenal medulla.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Carboxypeptidase H; Carboxypeptidases; Cobalt; Dansyl Compounds; Enkephalins; Epinephrine; Kinetics; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Splanchnic Nerves; Succinates | 1990 |
Effects of enteric neural defunctioning on small bowel motility.
Topics: Animals; Bethanechol Compounds; Cobalt; Dogs; Electrophysiology; Gastrointestinal Motility; Intestine, Small; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Perfusion; Tetrodotoxin | 1990 |
Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein.
Topics: Animals; Base Sequence; Cell Nucleus; Cobalt; Erythropoietin; Female; Gene Expression Regulation; Humans; Kidney; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligonucleotide Probes; Reference Values; Ribonucleoproteins; Sequence Homology, Nucleic Acid | 1990 |
Brain pathways of the chromatophore system in the squid Lolliguncula brevis.
Topics: Animals; Brain; Chromatophores; Cobalt; Decapodiformes; Iontophoresis; Neurons | 1990 |
Role of protein kinase C in renal vasoconstriction caused by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil | 1990 |
[Mechanism of stimulation by cobalt ions of sodium channels in the apical membrane of the frog skin (fluctuation analysis)].
Topics: Animals; Biological Transport; Cell Membrane; Cobalt; In Vitro Techniques; Ion Channels; Membrane Potentials; Models, Biological; Rana temporaria; Skin; Sodium | 1986 |
Cumulative depletions of extracellular calcium in rabbit ventricular muscle monitored with calcium-selective microelectrodes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Cobalt; Electric Stimulation; Extracellular Space; Heart; In Vitro Techniques; Microelectrodes; Myocardium; Nifedipine; Rabbits; Ryanodine; Strophanthidin | 1986 |
Tracing of single fibers of the nervus terminalis in the goldfish brain.
Topics: Animals; Axonal Transport; Brain; Cobalt; Functional Laterality; Goldfish; Horseradish Peroxidase; Neurons | 1986 |
Antigen specific human T cell lines specific for cobalt chloride.
Topics: Antibodies, Monoclonal; Antigens, Surface; Cell Division; Cell Line; Cobalt; Dermatitis, Contact; Epitopes; Erythrocytes; Histocompatibility Antigens Class II; Humans; In Vitro Techniques; Interleukin-2; Nickel; T-Lymphocytes | 1986 |
Delayed activation of calcium pump during transient increases in cellular Ca2+ concentration and K+ conductance in hyperpolarizing human red cells.
Topics: Biological Transport; Calcimycin; Calcium; Cobalt; Erythrocytes; Humans; Hydrogen-Ion Concentration; Ion Channels; Potassium | 1986 |
Modified cobalt staining and silver intensification techniques for use with whole-mount gastropod ganglion preparations.
Topics: Animals; Aplysia; Cobalt; Ganglia; Mollusca; Silver; Snails; Staining and Labeling | 1986 |
[Tumor scintigraphy with cobalt bleomycin in ORL tumors].
Topics: Bleomycin; Cobalt; Cobalt Radioisotopes; Combined Modality Therapy; Humans; Lymphatic Metastasis; Otorhinolaryngologic Neoplasms; Patient Care Planning; Radionuclide Imaging; Scintillation Counting | 1986 |
Functional organization of crayfish abdominal ganglia: I. The flexor systems.
Topics: Animals; Astacoidea; Axons; Cobalt; Dendrites; Female; Ganglia; Horseradish Peroxidase; Male; Motor Neurons; Neural Pathways; Staining and Labeling | 1986 |
Red blood cells Ca2+ pump is not altered in essential hypertension of humans and Kyoto rats.
Topics: Adult; Aged; Animals; Calcimycin; Calcium; Calcium Radioisotopes; Cobalt; Erythrocytes; Humans; Hypertension; Ion Channels; Kinetics; Male; Membrane Potentials; Middle Aged; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vanadates | 1987 |
Membrane currents that govern smooth muscle contraction in a ctenophore.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Calcium; Cell Membrane; Cnidaria; Cobalt; Electric Conductivity; Ion Channels; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Tetraethylammonium; Tetraethylammonium Compounds | 1988 |
[Development of electrical activity of hypothalamic cells in culture].
Topics: Animals; Barium; Barium Compounds; Calcium; Cells, Cultured; Chlorides; Cobalt; Electric Conductivity; Electrophysiology; Embryo, Mammalian; Hypothalamus; Ion Channels; Mice; Neurons; Sodium; Tetrodotoxin; Time Factors | 1987 |
Intracellular calcium concentration and growth hormone secretion in individual somatotropes: effects of growth hormone-releasing factor and somatostatin.
Topics: Animals; Benzofurans; Calcium; Cobalt; Cytosol; Fluorescent Dyes; Fura-2; Growth Hormone; Growth Hormone-Releasing Hormone; Hemolytic Plaque Technique; Ion Channels; Male; Microscopy, Fluorescence; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin; Verapamil | 1988 |
Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Cells, Cultured; Cobalt; Ethers; Fetus; Gastrointestinal Hormones; Glucagon-Like Peptides; Intestinal Mucosa; Intestines; Ionomycin; Kinetics; Magnesium; Magnesium Chloride; Peptides; Phorbol Esters; Rats; Rats, Inbred Strains | 1988 |
Protection of chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality by partial hepatectomy.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlordecone; Cobalt; Cytochrome P-450 Enzyme System; Drug Synergism; Glutathione; Hepatectomy; Insecticides; Liver; Male; Microsomes, Liver; Mitosis; Organ Size; Rats; Rats, Inbred Strains | 1988 |
The effect of barium and some channel blockers on sensory discharge of the frog labyrinth posterior canal recorded at rest and during rotation.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Barium; Calcium; Cobalt; Ear, Inner; Ion Channels; Rana esculenta; Tetraethylammonium Compounds | 1988 |
Immunohistochemistry of estrogen receptor protein in paraffin sections. Effects of enzymatic pretreatment and cobalt chloride intensification.
Topics: Charcoal; Cobalt; Deoxyribonucleases; Dextrans; Female; Freezing; Histological Techniques; Humans; Immunohistochemistry; p-Dimethylaminoazobenzene; Paraffin; Receptors, Estrogen; Trypsin | 1988 |
Topography and morphology of retinal ganglion cells in the coral trout Plectropoma leopardus (Serranidae): a retrograde cobaltous-lysine study.
Topics: Animals; Cobalt; Lysine; Optic Nerve; Retina; Retinal Ganglion Cells; Salmonidae; Staining and Labeling; Trout | 1989 |
[Effect of cobalt on the levels and distribution of nucleic acids in the retina and choroid of guinea pigs].
Topics: Animals; Choroid; Cobalt; DNA; Guinea Pigs; Retina; RNA; Stimulation, Chemical | 1988 |
Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cattle; Cobalt; Cyclic AMP; Electric Conductivity; Gallopamil; Kinetics; Lipid Bilayers; Muscles; Phosphorylation; Protein Kinases; Rabbits; Receptors, Nicotinic | 1989 |
Microsomal metabolism of hexavalent chromium. Inhibitory effect of oxygen and involvement of cytochrome P-450.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromium; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Kinetics; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Minimum eliciting patch test concentrations of cobalt.
Topics: Adult; Animals; Cobalt; Dermatitis, Contact; Edetic Acid; False Negative Reactions; False Positive Reactions; Female; Guinea Pigs; Humans; Male; Middle Aged; Patch Tests; Skin Absorption; Skin Tests; Sodium Dodecyl Sulfate | 1989 |
Comparative studies on the inducing effects of cobalt chloride and co-protoporphyrin on hepatic ornithine decarboxylase and heme oxygenase in rats.
Topics: Animals; Cobalt; Diamines; Eflornithine; Enzyme Induction; Heme Oxygenase (Decyclizing); Liver; Male; Maleates; Mixed Function Oxygenases; Ornithine Decarboxylase; Polyamines; Porphyrins; Protoporphyrins; Putrescine; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Primary culture of teleocalcin cells from rainbow trout corpuscles of Stannius: regulation of teleocalcin secretion by calcium.
Topics: Animals; Calcimycin; Calcium; Cells, Cultured; Cobalt; Culture Media; Egtazic Acid; Endocrine Glands; Glycoproteins; Hormones; Nifedipine; Osmotic Pressure; Pituitary Hormones; Salmonidae; Trout; Verapamil | 1989 |
Involvement of metabolites in the inhibitory effects of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AD-2646), a new quinoline derivative, on gastric acid secretion. A comparison with tricyclic antidepressants.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cobalt; Deoxyglucose; Duodenum; Electric Stimulation; Gastric Acid; Imipramine; Intubation, Gastrointestinal; Male; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Time Factors; Vagus Nerve | 1989 |
Role of the environment in the interaction of nonintercalators with Z-DNA.
Topics: Chemical Phenomena; Chemistry; Chlorides; Cobalt; Distamycins; DNA; Ethanol; Guanidines; Ligands; Magnesium Chloride; Molecular Conformation; Netropsin; Polyamines; Polydeoxyribonucleotides; Pyrroles; Sodium Chloride; Spectrum Analysis | 1989 |
Electrophysiological properties of rat CA1 pyramidal neurones in vitro modified by changes in extracellular bicarbonate.
Topics: Action Potentials; Amino Acids; Animals; Bicarbonates; Cobalt; Hippocampus; In Vitro Techniques; Ketamine; Membrane Potentials; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Sensory Thresholds; Synapses; Tetrodotoxin; Time Factors | 1989 |
The role of Ca influx in cardiac muscle excitation-contraction coupling. Assessment by extracellular Ca microelectrodes.
Topics: Animals; Caffeine; Calcium; Cardiac Pacing, Artificial; Cobalt; Culture Techniques; Electrocardiography; Extracellular Space; Ion Channels; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Rabbits; Sarcoplasmic Reticulum; Sodium; Verapamil | 1985 |
Synergistic induction of rat hepatic ornithine decarboxylase by multiple doses of cobalt chloride.
Topics: Animals; Carbon Tetrachloride; Cobalt; Cycloheximide; Drug Administration Schedule; Drug Synergism; Enzyme Induction; Injections, Subcutaneous; Kinetics; Liver; Male; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Reference Values; Thioacetamide | 1989 |
Mechanism of biological formation of cannabielsoin from cannabidiol in the guinea-pig, mouse, rat and rabbit.
Topics: Animals; Benzoflavones; Cannabidiol; Cannabinoids; Chromatography, Gas; Cobalt; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Guinea Pigs; In Vitro Techniques; Male; Metyrapone; Mice; Mice, Inbred Strains; Microsomes, Liver; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
[Utilization of CoCl2 for karyological studies in teleosts].
Topics: Animals; Catfishes; Cobalt; Erythroblasts; Erythropoiesis; Ictaluridae; Karyotyping; Kidney; Mitosis | 1989 |
Effect of methylene blue and cobaltous chloride on the alloxan-induced changes in collagen characteristics in the skin of garden lizard Calotes versicolor.
Topics: Aging; Alloxan; Animals; Cobalt; Collagen; Drug Interactions; Lizards; Methylene Blue; Skin | 1989 |
Anterograde labelling from the optic nerve reveals multiple central targets in teleost, Lethrinus chrysostomus (Perciformes).
Topics: Animals; Brain; Brain Mapping; Cobalt; Optic Nerve; Perciformes; Visual Pathways | 1989 |
Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N.
Topics: 3-Mercaptopropionic Acid; Blood Coagulation Tests; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Cobalt; Dithiothreitol; Enzyme Activation; Enzyme Stability; Esterases; Female; Heparin; Humans; Hydrogen-Ion Concentration; Lysine Carboxypeptidase; Male; Plasma; Substrate Specificity; Temperature | 1989 |
Acute effect of amitriptyline, phenobarbital or cobaltous chloride on delta-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver.
Topics: 5-Aminolevulinate Synthetase; Amitriptyline; Animals; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).
Topics: Cobalt; Enzyme Activation; GPI-Linked Proteins; Humans; Hydrogen-Ion Concentration; Metalloendopeptidases; Microvilli; Succinates | 1989 |
Elimination of nickel, cobalt, and chromium following repeated injections of high dose metal salts.
Topics: Animals; Chromates; Cobalt; Cricetinae; Drug Administration Schedule; Injections, Intramuscular; Male; Mesocricetus; Nickel; Potassium Dichromate; Reference Values; Tissue Distribution | 1989 |
Effects of perphenazine, chlorpromazine or CoCl2 on the activities of delta-aminolevulinic acid synthetase and heme oxygenase and on the content of hemoprotein in rat liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Chlorpromazine; Cobalt; Enzyme Induction; Heme Oxygenase (Decyclizing); Hemeproteins; Liver; Male; Mixed Function Oxygenases; Perphenazine; Rats; Rats, Inbred Strains | 1989 |
Histopathological studies on experimental marine toxin poisoning--4. Pathogenesis of experimental maitotoxin poisoning.
Topics: Adrenal Cortex; Adrenalectomy; Animals; Calcium; Cobalt; Hydrocortisone; Immunoglobulin M; Injections, Intraperitoneal; Male; Marine Toxins; Mice; Mice, Inbred ICR; Oxocins; Spleen; Subcellular Fractions; Thymus Gland | 1989 |
Allergy to nickel or cobalt: tolerance to nickel and cobalt samples in man and in the guinea pig allergic or sensitized to these metals.
Topics: Animals; Chromium; Cobalt; Copper; Dermatitis, Contact; Female; Guinea Pigs; Humans; Immunization; Nickel; Patch Tests | 1989 |
Comparative effects of repeated parenteral administration of several chelators on the distribution and excretion of cobalt.
Topics: Acetylcysteine; Animals; Chelating Agents; Cobalt; Edetic Acid; Glutathione; Injections, Intraperitoneal; Male; Pentetic Acid; Rats; Rats, Inbred Strains; Succimer | 1988 |
Enhancement of monomethylaminoantipyrine-induced increase of hepatic gamma-glutamyltranspeptidase activity by cobaltous chloride in rats.
Topics: Aminopyrine; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytosol; Dipyrone; Drug Synergism; gamma-Glutamyltransferase; In Vitro Techniques; Liver; Male; Microsomes, Liver; Pyrazolones; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Cobalt-dependent stimulation of sodium transport in the amphibian skin and nephron.
Topics: Animals; Cobalt; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Nephrons; Organ Specificity; Rana temporaria; Skin; Skin Physiological Phenomena; Sodium; Species Specificity; Triturus | 1986 |
Ligand binding studies of the F1 moiety of rat liver ATP synthase: implications about the enzyme's structure and mechanism.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Cobalt; Kinetics; Ligands; Macromolecular Substances; Mitochondria, Liver; Protein Binding; Proton-Translocating ATPases; Rats; Ribonucleotides | 1987 |
Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamate.
Topics: Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Aspartic Acid; Calcium Chloride; Carrier Proteins; Cells, Cultured; Cerebellum; Cobalt; Glutamates; Glutamic Acid; Glutamine; Mice; Succinates | 1988 |
Dissociation of fibrinogen and fibronectin binding from transglutaminase-mediated cross-linking at the hepatocyte surface.
Topics: Animals; Calcium; Cations, Divalent; Cells, Cultured; Cobalt; Cross-Linking Reagents; Edetic Acid; Fibrinogen; Fibronectins; Heparin; Hirudins; Kinetics; Ligands; Liver; Protein Binding; Putrescine; Rabbits; Transglutaminases | 1988 |
Receptor position, not nerve branch, determines electroreceptor somatotopy in the gymnotiform fish (Apteronotus leptorhynchus).
Topics: Animals; Cobalt; Electric Fish; Female; Head; Horseradish Peroxidase; Male; Neurons, Afferent; Peripheral Nerves; Sensory Receptor Cells | 1989 |
The human 32-kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase.
Topics: Anions; Arsenic; Arsenites; Cadmium; Cations; Cobalt; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; HeLa Cells; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hot Temperature; Humans; Immunoblotting; Leukemia; Mixed Function Oxygenases; Molecular Weight; Tumor Cells, Cultured | 1989 |
Neuropharmacological actions of kynurenic and quinolinic acids on horizontal cells of the isolated fish retina.
Topics: Animals; Aspartic Acid; Cobalt; Cyprinidae; Evoked Potentials, Visual; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Photic Stimulation; Pyridines; Quinolinic Acid; Quinolinic Acids; Retina | 1986 |
Contact dermatitis from nickel: an investigation of its sources.
Topics: Cobalt; Dermatitis, Contact; Dermatitis, Occupational; Female; Humans; Male; Metals; Nickel; Patch Tests; Spain | 1988 |
Thermal denaturation of rat pulmonary and testicular angiotensin-converting enzyme isozymes. Effects of chelators and CoCl2.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chelating Agents; Cobalt; Hot Temperature; In Vitro Techniques; Isoenzymes; Lung; Male; Organ Specificity; Protein Denaturation; Rats; Rats, Inbred Strains; Testis | 1985 |
[Modulating action of barium and other ions on the sensory activity of frog labyrinth].
Topics: 4-Aminopyridine; Aminopyridines; Animals; Anura; Barium; Calcium; Cobalt; Ear, Inner; Electrophysiology; Potassium; Tetraethylammonium Compounds | 1985 |
Regional difference in depolarization-elicited accumulation of cyclic AMP in cobalt-induced epileptic cortex of the rat.
Topics: Animals; Cerebral Cortex; Cobalt; Cyclic AMP; Electroencephalography; Epilepsy; Male; Rats; Rats, Inbred Strains | 1985 |
Somata-selective lesions induced by cobaltous chloride: a parametric study.
Topics: Animals; Cats; Cell Survival; Cobalt; Depression, Chemical; Geniculate Bodies; Synaptic Transmission; Visual Pathways | 1986 |
TRH and GRF stimulate release of growth hormone through different mechanisms.
Topics: Animals; Bucladesine; Calcium; Cells, Cultured; Cobalt; Cyclic AMP; Egtazic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Peptide Fragments; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Thyroidectomy; Thyrotropin-Releasing Hormone; Verapamil | 1986 |
Simultaneous spectrophotometric calibration of wavelength and absorbance in an interlaboratory survey using holmium oxide (Ho2O3) in perchloric acid as reference, compared with p-nitrophenol and cobaltous sulphate solutions (1978-1984).
Topics: Chemical Phenomena; Chemistry; Cobalt; Holmium; Nitrophenols; Perchlorates; Reference Standards; Solutions; Spectrophotometry, Ultraviolet | 1986 |
Further studies on the mechanism of action of leukotrienes and histamine on guinea pig lung parenchyma. Role of calcium, phospholipase and methyltransferase.
Topics: Animals; Calcium; Cobalt; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; In Vitro Techniques; Leukotriene B4; Lung; Muscle Contraction; SRS-A; Tetrodotoxin; Trifluoperazine; Tubercidin; Valinomycin; Verapamil | 1986 |
Ontogeny of the in vitro growth hormone stimulatory effect of thyrotropin-releasing hormone in the rat.
Topics: Animals; Bucladesine; Calcium Channel Blockers; Cobalt; Dose-Response Relationship, Drug; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Peptide Fragments; Pregnancy; Rats; Rats, Inbred Strains; Thyroid Gland; Thyrotropin-Releasing Hormone | 1986 |
Isotope effect evidence for the zinc hydroxide mechanism of carbonic anhydrase catalysis.
Topics: Animals; Bicarbonates; Carbonic Anhydrases; Cattle; Cobalt; Deuterium; Deuterium Oxide; Erythrocytes; Hydroxides; Kinetics; Oxygen Isotopes; Water; Zinc; Zinc Compounds | 1987 |
Simple and sensitive CO2 laser visual screen.
Topics: Carbon Dioxide; Cobalt; Laser Therapy; Silica Gel; Silicon Dioxide | 1987 |
Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Blood Vessels; Cobalt; Cytochrome P-450 Enzyme System; Drug Synergism; Endothelium; Fatty Acids; Indomethacin; Male; Methylcholanthrene; Oxygenases; Phenylephrine; Proadifen; Pulmonary Artery; Pyrazoles; Rabbits; Vasoconstriction; Vasodilation | 1986 |
Induction of L-alanine:4,5-dioxovalerate transaminase by phenylhydrazine is associated with depletion of heme level.
Topics: Anemia; Animals; Cobalt; Dactinomycin; Erythropoietin; Hematocrit; Heme; Immune Sera; Immunodiffusion; Kidney; Kinetics; Liver; Male; Phenylhydrazines; Rats; Rats, Inbred Strains; Transaminases | 1986 |
Dependence of GnRH action on Na+, K+, and Ca2+ in the frog, Rana pipiens, pituitary.
Topics: Animals; Calcium Chloride; Cobalt; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; In Vitro Techniques; Kinetics; Luteinizing Hormone; Male; Perfusion; Pituitary Gland; Potassium Chloride; Rana pipiens; Sodium Chloride; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1986 |
Structural and functional differences between the two intrinsic zinc ions of Escherichia coli RNA polymerase.
Topics: Cadmium; Cadmium Chloride; Cobalt; DNA-Directed RNA Polymerases; Edetic Acid; Escherichia coli; Kinetics; Protein Binding; Spectrophotometry; Zinc | 1986 |
Effect of co-administration of interferon inducer, polyriboinosinic acid-polyribocytidylic acid, with SKF 525-A on hepatic drug metabolizing enzymes of rats.
Topics: Animals; Benzopyrene Hydroxylase; Cobalt; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Glucuronosyltransferase; Heme Oxygenase (Decyclizing); Liver; Male; Poly I-C; Proadifen; Rats; Rats, Inbred Strains | 1986 |
Calcium participation in thyroid function in fowl (Gallus domesticus).
Topics: Animals; Calcium; Chickens; Cobalt; Egtazic Acid; Magnesium; Magnesium Chloride; Male; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1987 |
Role of metabolism in effects of diflubenzuron on growth of B16 melanomas in mice.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cobalt; Diflubenzuron; Female; Hydroxylation; Juvenile Hormones; Melanoma; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases | 1986 |
Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine.
Topics: Bromobenzenes; Cell Line; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Erythroblastic, Acute; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidine | 1987 |
Control of oxytocin secretion by ovine corpora lutea: effects of arachidonic acid, phospholipases, and prostaglandins.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cobalt; Corpus Luteum; Dinoprost; Dinoprostone; Female; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Masoprocol; Oxytocin; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandins; Prostaglandins E; Prostaglandins F; Sheep; Type C Phospholipases | 1988 |
Imaging of the degeneration of neurons and their processes in rat or cat brain by 45CaCl2 autoradiography or 55CoCl2 positron emission tomography.
Topics: Animals; Autoradiography; Brain; Brain Diseases; Calcium; Calcium Chloride; Calcium Radioisotopes; Cats; Cobalt; Cobalt Radioisotopes; Corpus Striatum; Frontal Lobe; Hippocampus; Hydroxydopamines; Kainic Acid; Male; Nerve Degeneration; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra; Tomography, Emission-Computed | 1988 |
Chemistry set chemicals: an evaluation of their toxic potential.
Topics: Adolescent; Chemical Phenomena; Chemistry; Cobalt; Edetic Acid; Female; Hazardous Substances; Hobbies; Humans; Sodium Chloride | 1988 |
Effects of Ca2+ entry blockers on kainate-induced changes in extracellular amino acids and Ca2+ in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Channel Blockers; Cobalt; Flunarizine; Hippocampus; Kainic Acid; Nimodipine; Rabbits; Verapamil | 1987 |
False-positive, follicular and irritant patch test reactions to metal salts.
Topics: Chromates; Cobalt; Dermatitis, Contact; Dermatitis, Occupational; False Positive Reactions; Hand; Humans; Nickel; Patch Tests; Potassium Dichromate | 1985 |
Analysis of proprioceptive inputs to DPG interneurons in the cockroach.
Topics: Animals; Cobalt; Cockroaches; Extremities; Interneurons; Neural Pathways; Neurons, Afferent; Physical Stimulation; Proprioception | 1988 |
Paradoxical effect of cobaltous chloride on carbon disulfide induced hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Cobalt; Glutathione; Liver; Male; Rats; Rats, Inbred Strains | 1988 |
Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Cells, Cultured; Choline; Cobalt; Glutathione; Kinetics; Liver; Male; Membrane Potentials; Ouabain; Potassium; Rats; Rats, Inbred Strains | 1988 |
Nickel sensitivity: effects of prolonged oral intake of the element.
Topics: Administration, Oral; Adult; Cobalt; Dermatitis, Contact; Female; Follow-Up Studies; Humans; Nickel; Patch Tests; Time Factors | 1988 |
Effect of fluoride and cobalt on forming enamel: scanning electron microscope and X-ray microanalysis study.
Topics: Animals; Cobalt; Dental Enamel; Electron Probe Microanalysis; Freeze Drying; Incisor; Male; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Sodium Fluoride; Trypsin | 1988 |
Nephrotoxicity of N-(3,5-dichlorophenyl)succinimide metabolites in vivo and in vitro.
Topics: Animals; Cobalt; Fungicides, Industrial; In Vitro Techniques; Kidney; Male; p-Aminohippuric Acid; Phenobarbital; Rats; Rats, Inbred F344; Succinimides | 1988 |
Human placental dipeptidyl aminopeptidase III: hydrolysis of enkephalins and its stimulation by cobaltous ion.
Topics: Cations, Divalent; Cobalt; Cytosol; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enkephalins; Female; Humans; Hydrolysis; Kinetics; Oligopeptides; Placenta; Pregnancy; Substrate Specificity | 1988 |
The existence of specific antibodies to cobalt in hard metal asthma.
Topics: Adult; Antibodies; Asthma; Cobalt; Cobalt Radioisotopes; Humans; Immunoglobulin E; Middle Aged; Occupational Diseases; Radioallergosorbent Test | 1988 |
The tritocerebral commissure 'dwarf' (TCD): a major GABA-immunoreactive descending interneuron in the locust.
Topics: Action Potentials; Animals; Brain; Brain Mapping; Cobalt; Efferent Pathways; gamma-Aminobutyric Acid; Ganglia; Grasshoppers; Immunohistochemistry; Interneurons; Neurons, Afferent; Photic Stimulation; Physical Stimulation | 1988 |
Inverse correlation between combined mutagenicity in Salmonella typhimurium and strength of coordinate bond in mixtures of cobalt(II) chloride and 4-substituted pyridines.
Topics: Cobalt; Drug Interactions; Isonicotinic Acids; Mutagenicity Tests; Pyridines; Salmonella typhimurium; Structure-Activity Relationship | 1988 |
Induction of respiratory deficiency in yeast by salts of chromium, arsenic, cobalt and lead.
Topics: Arsenic; Arsenites; Chromates; Cobalt; Lead; Mitochondria; Nitrates; Oxygen Consumption; Potassium Dichromate; Saccharomyces cerevisiae; Sodium Compounds | 1987 |
The isolation and characterization of Ni2+ resistant mutants of Saccharomyces cerevisiae.
Topics: Cadmium; Cadmium Chloride; Cobalt; Copper; Copper Sulfate; Drug Resistance, Microbial; Fungal Proteins; Mutation; Nickel; RNA, Fungal; Saccharomyces cerevisiae | 1987 |
Heme regulates cytochrome P-450 gene transcription elongation.
Topics: Animals; Cell Nucleus; Cobalt; Cytochrome P-450 Enzyme System; Genes; Heme; Kinetics; Methylcholanthrene; Rats; RNA, Messenger; Transcription, Genetic | 1988 |
Hepatic lipid peroxidation in CoCl2-treated rats, evidenced by elevated concentrations of thiobarbituric acid chromogens.
Topics: Animals; Chromogenic Compounds; Cobalt; Kidney; Lipid Peroxides; Liver; Male; Organ Size; Rats; Rats, Inbred F344; Thiobarbiturates | 1988 |
Heme is a positive regulator of cytochrome P-450 gene transcription.
Topics: Amitrole; Animals; Base Sequence; Cobalt; Cytochrome P-450 Enzyme System; DNA; DNA, Recombinant; Heme; Male; Methylcholanthrene; Molecular Sequence Data; Nucleic Acid Hybridization; Rats; RNA, Messenger; Thioacetamide; Transcription, Genetic | 1988 |
Morphology of neurones associated with the antennal heart of Periplaneta americana (Blattodea, Insecta).
Topics: Animals; Cobalt; Cockroaches; Ganglia; Heart; Male; Neurons | 1988 |
Secretory ameloblasts and calcium distribution during normal and experimentally altered mineralization.
Topics: Ameloblasts; Animals; Calcium; Cobalt; Cytoplasmic Granules; Dental Enamel; Electron Probe Microanalysis; Incisor; Microscopy, Electron; Microscopy, Electron, Scanning; Rats; Sodium Fluoride | 1987 |
Morphology, ultrastructure and synapse distribution of putative serotonergic salivary neurons in the locust.
Topics: Animals; Cobalt; Coloring Agents; Grasshoppers; Microscopy, Electron; Salivary Glands; Serotonin; Synapses | 1987 |
Two different 7-ethoxycoumarin O-deethylase activities in mice after pretreatment with sulmazole and cobaltous chloride.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cobalt; Dealkylation; Electrophoresis, Polyacrylamide Gel; Imidazoles; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxygenases; Sodium Dodecyl Sulfate; Umbelliferones | 1986 |
Detection of natural bio-antimutagens and in vivo and in vitro analysis of their action.
Topics: Acrolein; Cobalt; DNA Repair; Escherichia coli; Female; Germanium; Humans; Mutagenicity Tests; Mutagens; Mutation; Placenta; Pregnancy; Salmonella typhimurium; Tissue Extracts; Ultraviolet Rays | 1986 |
Combined mutagenicity of cobalt(II) salt and heteroaromatic compounds in Salmonella typhimurium.
Topics: Cobalt; Drug Synergism; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Molecular Conformation; Salmonella typhimurium | 1986 |
Calcium antagonists stimulate prostaglandin synthesis by cultured rat cardiac myocytes and prevent the effects of hypoxia.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cells, Cultured; Cobalt; Diltiazem; Dinoprostone; Epoprostenol; Fibroblasts; Glycogen; Heart; Hypoxia; Myocardium; Prostaglandins E; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil | 1986 |
[Fatty acid analysis of tissue in liporegulation].
Topics: Alloxan; Animals; Carbon Tetrachloride Poisoning; Cobalt; Diabetes Mellitus, Experimental; Fatty Acids; Fatty Acids, Unsaturated; Intestine, Small; Islets of Langerhans; Lipids; Liver; Male; Rats | 1986 |
Application of a hepatocyte-erythrocyte coincubation system to studies of cyanide antidotal mechanisms.
Topics: Adenosine Triphosphate; Aminophenols; Animals; Antidotes; Cell Survival; Cobalt; Cyanides; Erythrocytes; In Vitro Techniques; Liver; Male; Potassium Cyanide; Rats; Rats, Inbred Strains; Sodium Nitrite; Thiosulfates | 1987 |
Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
Topics: Aminopyrine; Animals; Cobalt; Dipyrone; Drinking; Drug Interactions; Eating; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Liver; Male; Organ Size; Pyrazolones; Rats; Rats, Inbred Strains; Transferases | 1987 |
A head-only exposure system for controlled exposures of small rodents.
Topics: Aerosols; Animals; Atmosphere Exposure Chambers; Cobalt; Equipment Design; Evaluation Studies as Topic; Lung; Male; Nickel; Rats; Rats, Inbred Strains | 1987 |
[Experimental studies on antidotes for the insecticides bancol and nereistoxin acute poisoning].
Topics: Animals; Benzenesulfonates; Cobalt; Female; Insecticides; Male; Marine Toxins; Mice; Rats; Rats, Inbred Strains | 1987 |
[Effect of cobalt on the distribution and composition of lipids in the retina and optic nerve of guinea pigs].
Topics: Animals; Cobalt; Guinea Pigs; Lipid Metabolism; Optic Nerve; Retina | 1987 |
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme.
Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger | 1987 |
Histamine affects release and biosynthesis of opioid peptides primarily via H1-receptors in bovine chromaffin cells.
Topics: Adrenal Glands; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Cimetidine; Clemastine; Cobalt; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gallopamil; Histamine; Histamine Antagonists; Nifedipine; Protein Precursors; Pyrilamine; Ranitidine; Receptors, Histamine; Receptors, Histamine H1; RNA, Messenger | 1987 |
High-performance liquid chromatographic identification and determination of dithiocarbamates in vulcanized rubber products.
Topics: Chromatography, High Pressure Liquid; Cobalt; Rubber; Spectrophotometry, Ultraviolet; Thiocarbamates; Zinc | 1987 |
Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Carbon Monoxide; Cobalt; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Hydroxylation; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Pargyline; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Two components of voltage-dependent calcium influx in mouse neuroblastoma cells. Measurement with arsenazo III.
Topics: Animals; Arsenazo III; Azo Compounds; Calcium; Cobalt; Electrophysiology; Extracellular Space; Mice; Neuroblastoma; Tetraethylammonium; Tetraethylammonium Compounds | 1986 |
Practolol: aspects of its metabolism and ocular binding in the hamster.
Topics: Animals; Cobalt; Cricetinae; Eye; Male; Mesocricetus; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Practolol | 1986 |
[Effect of cobalt chloride on the activity of key enzymes of heme metabolism in the rat liver].
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Cycloheximide; Dactinomycin; Enzyme Activation; Heme; Heme Oxygenase (Decyclizing); Kinetics; Liver; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1986 |
[Assessment of the erythropoietin-producing function of the kidney and liver under controlled perfusion].
Topics: Animals; Cobalt; Dogs; Erythropoiesis; Erythropoietin; Hemorrhage; Kidney; Liver; Male; Mice; Mice, Inbred CBA; Perfusion; Polycythemia | 1986 |
Oxidative metabolism of carbon disulfide by isolated rat hepatocytes and microsomes.
Topics: Acetazolamide; Animals; Carbon Disulfide; Cobalt; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Sulfur | 1987 |
[Saturated, mono-unsaturated and polyunsaturated fatty acids in the regulation of fat].
Topics: Adipose Tissue; Alloxan; Animals; Carbon Tetrachloride; Cobalt; Dietary Fats; Dietary Fats, Unsaturated; Fatty Acids; Hepatectomy; Liver; Male; Muscles; Rats | 1986 |
Regulation of cytochrome P-450 gene expression. Studies with a cloned probe.
Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; DNA; Gene Expression Regulation; Male; Microsomes, Liver; Nucleic Acid Hybridization; Phenobarbital; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic | 1985 |
Effect of cobalt on biliary excretion of bilirubin and glutathione.
Topics: Animals; Bile; Bilirubin; Chromatography, High Pressure Liquid; Cobalt; Glutathione; Heme; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains | 1985 |
Effects of cupric ions on isolated guinea-pig ileum.
Topics: Animals; Autonomic Nervous System; Cobalt; Copper; Electric Stimulation; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nickel; Nitroprusside; Verapamil | 1985 |
Influence of pyrazolones on hepatic glutathione in rats.
Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide | 1985 |
Genotoxic effects of potassium dichromate, sodium arsenite, cobalt chloride and lead nitrate in diploid yeast.
Topics: Arsenic; Arsenites; Chromates; Cobalt; Gene Conversion; Genes, Fungal; Lead; Microbial Sensitivity Tests; Mutagenicity Tests; Nitrates; Potassium Dichromate; Saccharomyces cerevisiae; Sodium Compounds | 1985 |
Postrest inotropy in rabbit ventricle: Na+-Ca2+ exchange determines sarcoplasmic reticulum Ca2+ content.
Topics: Animals; Calcium; Cobalt; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Periodicity; Rabbits; Ryanodine; Sarcoplasmic Reticulum; Sodium; Strophanthidin | 1986 |
Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.
Topics: Animals; Cobalt; Dose-Response Relationship, Drug; Heme; Kinetics; Liver; Male; Metalloporphyrins; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1985 |
Effect of cobaltous chloride on butylated hydroxytoluene-induced hepatic necrosis in rats.
Topics: Animals; Bile Acids and Salts; Butylated Hydroxytoluene; Cobalt; Drug Interactions; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; Transaminases | 1985 |
Effects of mixed-function oxidase modifiers on neurotoxicity of acrylamide in rats.
Topics: Acrylamide; Acrylamides; Animals; Cobalt; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Male; Mixed Function Oxygenases; Nervous System; Paralysis; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
After-hyperpolarization and receptor potential attenuation following bursts of action potentials in an insect mechanoreceptor.
Topics: Action Potentials; Animals; Cobalt; Cockroaches; Electrophysiology; Mechanoreceptors; Ouabain; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1985 |
Colorimetric analysis of some diuretic drugs: hydrochlorothiazide and spironolactone.
Topics: Chemical Phenomena; Chemistry; Cobalt; Colorimetry; Hydrochlorothiazide; Hydrogen-Ion Concentration; Spironolactone; Tablets; Time Factors | 1985 |
pH shifts and precipitation associated with metal ions in tissue culture.
Topics: Animals; Chlorides; Chromium; Chromium Compounds; Cobalt; Corrosion; Culture Techniques; Ferric Compounds; Humans; Hydrogen-Ion Concentration; Metals; Nickel; Prostheses and Implants | 1985 |
N-acetyl-L-cysteine in acute cobalt poisoning.
Topics: Acetylcysteine; Animals; Cobalt; Male; Rats; Rats, Inbred Strains | 1985 |
[Mechanisms of development and blockade of epileptic activity in the brain].
Topics: Animals; Anticonvulsants; Camphor; Cell Membrane Permeability; Cobalt; Convulsants; Electric Conductivity; Epilepsy; Ganglia; Helix, Snails; In Vitro Techniques; Models, Neurological; Pentylenetetrazole; Strychnine | 1985 |
Turnover of messenger RNA, apoprotein and haem of cytochrome P-450b + e induced by phenobarbitone in rat liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Heme; Liver; Male; Phenobarbital; Rats; RNA, Messenger | 1985 |
Seizures induced by intraventricular microinjection of ionized cobalt in the rat--a new experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Injections, Intraventricular; Microinjections; Rats; Rats, Inbred Strains; Seizures | 1985 |
Interrelationship of nickel and cobalt contact sensitization.
Topics: Animals; Cobalt; Dermatitis, Contact; Guinea Pigs; Nickel; Patch Tests; Skin | 1985 |
Rabbit lung after inhalation of manganese chloride: a comparison with the effects of chlorides of nickel, cadmium, cobalt, and copper.
Topics: Animals; Cadmium; Cadmium Chloride; Chlorides; Cobalt; Copper; Lung; Macrophages; Male; Manganese Compounds; Manganese Poisoning; Microscopy, Electron; Nickel; Oxides; Phospholipids; Rabbits | 1985 |
[Effect of the induction and inhibition of microsomal oxidases on the course of hemorrhagic shock].
Topics: Animals; Barbiturates; Blood Volume; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Rabbits; Shock, Hemorrhagic | 1985 |
Specific nuclear staining of leukocytes, macrophages and mast cells using a diaminobenzidine-cobalt chloride mixture.
Topics: 3,3'-Diaminobenzidine; Cobalt; Female; Humans; Leukocytes; Macrophages; Mast Cells; Methods; Pregnancy; Staining and Labeling | 1984 |
Interactions of heavy metals with the pulmonary metabolism of [3H]benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Biotransformation; Cadmium; Cadmium Chloride; Chromatography, High Pressure Liquid; Cobalt; Drug Interactions; Indomethacin; Lung; Male; Metyrapone; Nickel; Rats; Rats, Inbred Strains; Tritium | 1984 |
RNA synthesis and degradation during preferential inhibition of protein synthesis by cobalt chloride in Escherichia coli K-12.
Topics: Cobalt; Escherichia coli; Half-Life; Kinetics; Protein Biosynthesis; Rifampin; RNA, Bacterial; RNA, Messenger; Transcription, Genetic | 1981 |
Cobalt destroys neurons without destroying fibers of passage in the lateral geniculate nucleus of the cat.
Topics: Animals; Axonal Transport; Cats; Cobalt; Efferent Pathways; Facial Nerve; Geniculate Ganglion; Horseradish Peroxidase; Neurons; Staining and Labeling; Visual Cortex | 1982 |
Somatocrinin (growth hormone releasing factor) in vitro bioactivity; Ca++ involvement, cAMP mediated action and additivity of effect with PGE2.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antihypertensive Agents; Calcium; Cholera Toxin; Cobalt; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Kinetics; Peptide Fragments; Pituitary Gland; Prostaglandins E; Radioimmunoassay; Rats; Somatostatin | 1982 |
Regulation of rat hepatic delta-aminolevulinic acid synthetase and heme oxygenase activities: evidence for control by heme and against mediation by prosthetic iron.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cobalt; Deferoxamine; Dextrans; Edetic Acid; Heme; Heme Oxygenase (Decyclizing); Iron-Dextran Complex; Kinetics; Liver; Male; Mixed Function Oxygenases; Protoporphyrins; Rats | 1983 |
[Pharmacological and clinico-pharmacological studies of a combination preparation for calves having antianemia and general tonic action].
Topics: Absorption; Anemia; Animals; Cattle; Cattle Diseases; Cobalt; Copper; Copper Sulfate; Drug Combinations; Drug Evaluation; Drug Evaluation, Preclinical; Drug Tolerance; Ferrous Compounds; gamma-Globulins; Iron-Dextran Complex; Male; Mice; Protein Hydrolysates; Rats; Rats, Inbred Strains; Vitamin B 12 | 1983 |
Non-serotonergic origins of the dorsolateral funiculus in the rat ventral medulla.
Topics: 3,3'-Diaminobenzidine; Analgesia; Animals; Cobalt; Histocytochemistry; Horseradish Peroxidase; Medulla Oblongata; Neural Pathways; Neurons; Rats; Serotonin; Spinal Cord; Staining and Labeling | 1984 |
In vitro testing for cobalt sensitivity: an aid to diagnosis.
Topics: Acetates; Adolescent; Adult; Aged; Cells, Cultured; Cobalt; Dermatitis, Contact; Humans; Lymphocytes; Middle Aged | 1984 |
Effect of metal allergens on the DNA synthesis of unsensitized guinea pig lymphoid cells cultured in vitro.
Topics: Allergens; Animals; Cells, Cultured; Cobalt; DNA; Guinea Pigs; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Male; Mercuric Chloride; Mercury; Metals; Nickel; Potassium Dichromate; Spleen; T-Lymphocytes | 1982 |
Photocontact dermatitis to cobalt salts.
Topics: Adult; Aged; Animal Feed; Animals; Cobalt; Construction Materials; Dermatitis, Occupational; Humans; Male; Middle Aged; Patch Tests; Photosensitivity Disorders; Spain; Swine | 1982 |
Effect of metal allergens on thymocytes from unsensitized guinea pigs: a comparative light and electron microscopic study.
Topics: Allergens; Animals; Cell Count; Cobalt; Guinea Pigs; Male; Mercuric Chloride; Mercury; Metals; Microscopy, Electron; Nickel; Potassium Dichromate; Thymus Gland; Time Factors | 1983 |
Inhibition of lymphoid cell DNA synthesis by metal allergens at various concentrations. Effect on short-time cultured nonadherent cells compared to nonseparated cells.
Topics: Allergens; Animals; Cell Adhesion; Cell Separation; Cells, Cultured; Cobalt; DNA; Guinea Pigs; Lymphocyte Activation; Lymphocytes; Male; Mercuric Chloride; Mercury; Nickel; Potassium Dichromate | 1983 |
Cobaltous chloride-induced hypothermia in mice III: effect of pretreatment with 5-hydroxytryptaminergic agents.
Topics: Animals; Body Temperature; Brain Chemistry; Cobalt; Fenclonine; Fluoxetine; Male; Mice; p-Chloroamphetamine; Serotonin; Serotonin Antagonists; Time Factors | 1983 |
Simultaneous sensitization to gum arabic and cobalt.
Topics: Adult; Cobalt; Dermatitis, Occupational; Gum Arabic; Humans; Male; Polysaccharides; Printing | 1984 |
Control of the variability of the afferent discharge rate in frog muscle spindle by potassium blockers.
Topics: Afferent Pathways; Animals; Barium; Barium Compounds; Cesium; Chlorides; Cobalt; Evoked Potentials; Ion Channels; Muscle Spindles; Potassium; Ranidae; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds | 1981 |
Conditions which cause the right-handed to left-handed DNA conformational transitions. Evidence for several types of left-handed DNA structures in solution.
Topics: Base Composition; Chlorides; Circular Dichroism; Cobalt; DNA; DNA Restriction Enzymes; Ethylene Glycols; Manganese; Manganese Compounds; Nucleic Acid Conformation; Solutions; Solvents; Spectrophotometry, Ultraviolet | 1982 |
Voltage-dependent Ca2+ channel and Na+ channel in frog taste cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cobalt; Egtazic Acid; Electric Stimulation; In Vitro Techniques; Ion Channels; Membrane Potentials; Rana catesbeiana; Sodium; Taste Buds; Tetrodotoxin | 1983 |
8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes.
Topics: Animals; Cobalt; Dronabinol; Isomerism; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; NADP; Phenobarbital | 1982 |
Rat liver microsomal transformation of ethene to oxirane in vitro.
Topics: Alkylation; Animals; Biotransformation; Cobalt; Ditiocarb; Ethylene Oxide; Ethylenes; Male; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Investigation of ability of the metal allergens cobalt chloride, nickel sulfate and potassium dichromate to give a mitogenic response in human thymocytes.
Topics: Allergens; Child; Child, Preschool; Cobalt; DNA Replication; Humans; Infant; Lymphocyte Activation; Mitogens; Nickel; Potassium Dichromate; T-Lymphocytes; Thymus Gland | 1984 |
Quantitative correlation between the metabolism and the mutagenic activity of N-nitrosopyrrolidine.
Topics: Animals; Biotransformation; Butylene Glycols; Cobalt; Hydroxylation; Male; Microsomes, Liver; Mutagenicity Tests; N-Nitrosopyrrolidine; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1984 |
Effects of Zn2+ on glucose-induced electrical activity and insulin release from mouse pancreatic islets.
Topics: Action Potentials; Animals; Chlorides; Cobalt; Electric Conductivity; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Zinc; Zinc Compounds | 1984 |
Abnormalities of cobalt-activated acylase from human sarcoma, carcinoma and the adjacent tissue.
Topics: Adenocarcinoma; Amidohydrolases; Cobalt; Drug Stability; Edetic Acid; Enzyme Activation; Female; Humans; Lung Neoplasms; Myosarcoma; Temperature; Uterine Neoplasms | 1983 |
The effect of the administration of cobaltic protoporphyrin IX on drug metabolism, carbon tetrachloride activation and lipid peroxidation in rat liver microsomes.
Topics: Animals; Carbon Tetrachloride; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Lipid Peroxides; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains | 1984 |
Calcium distribution in freeze-dried enamel organ tissue during normal and altered enamel mineralization.
Topics: Ameloblasts; Animals; Calcium; Cobalt; Dental Enamel; Electron Probe Microanalysis; Freeze Drying; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Minerals; Rats; Sodium Fluoride | 1984 |
Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels.
Topics: Aerobiosis; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cobalt; Cricetinae; Cricetulus; Cysteamine; Dose-Response Relationship, Radiation; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1984 |
The nature of the stimulatory action of gamma-aminobutyric acid in the isolated perfused dog adrenals.
Topics: Acetylcholine; Adrenal Glands; Animals; Atropine; Bicuculline; Calcium; Catecholamines; Cobalt; Dibucaine; Dogs; Female; gamma-Aminobutyric Acid; Hexamethonium Compounds; In Vitro Techniques; Kinetics; Male; Picrotoxin; Tetrodotoxin; Verapamil | 1984 |
Changes in the activity of gamma-amino butyric acid transaminase and succinic semialdehyde dehydrogenase in the cobalt and iron experimental epileptogenic foci in the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Chlorides; Cobalt; Electroencephalography; Epilepsy; Ferric Compounds; Hydroxybutyrate Dehydrogenase; Male; Rats | 1984 |
[Mechanism of the protective effect of modifiers of the liver enzyme systems metabolyzing xenobiotics in acute T-2 mycotoxicosis].
Topics: Acute Disease; Animals; Cobalt; Drug Evaluation, Preclinical; Enzyme Induction; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Sesquiterpenes; T-2 Toxin | 1984 |
The action of L-cysteine in acute cobalt chloride intoxication.
Topics: Administration, Oral; Animals; Antidotes; Cobalt; Cysteine; Female; Injections, Intraperitoneal; Rats; Rats, Inbred Strains | 1984 |
Effects of 4-aminopyridine on the field potentials of hippocampal slices.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cobalt; Dendrites; Evoked Potentials; Hippocampus; In Vitro Techniques; Nickel; Rats; Sodium | 1984 |
Chromatographic resolution and characterization of different casein phosphatase activities from the cytosolic compartment of rat erythrocytes.
Topics: Animals; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cobalt; Cytosol; Erythrocytes; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Rats; Rats, Inbred Strains; Substrate Specificity | 1984 |
Cycle length-dependent action potential duration in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Cobalt; Dogs; Female; Heart Conduction System; Homeostasis; In Vitro Techniques; Isoproterenol; Kinetics; Lidocaine; Male; Purkinje Fibers; Reaction Time; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Verapamil | 1984 |
Extrasystolic action potential and contraction in newborn rat myocardium.
Topics: Action Potentials; Animals; Animals, Newborn; Cobalt; Electric Stimulation; Heart; Myocardial Contraction; Rats; Verapamil | 1984 |
Effect of cobaltous chloride on aggregation of platelets from normal and afibrinogenaemic human blood.
Topics: Adenosine Diphosphate; Adolescent; Afibrinogenemia; Cobalt; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation | 1984 |
Treatment of acute cobalt intoxication in rats with L-methionine.
Topics: Acute Disease; Administration, Oral; Animals; Antidotes; Cobalt; Cysteine; Injections, Intraperitoneal; Lethal Dose 50; Male; Methionine; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1984 |
Purpuric contact dermatitis.
Topics: Animals; Antioxidants; Clothing; Cobalt; Dermatitis, Contact; Female; Humans; Male; Middle Aged; Patch Tests; Pressure; Purpura; Rubber; Wool | 1984 |
Toxicology of nickel.
Topics: Animals; Cadmium; Cadmium Chloride; Chromium; Cobalt; Copper; Dust; Lung; Macrophages; Nickel; Pulmonary Alveoli; Pulmonary Surfactants; Rabbits | 1984 |
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Glutathione; Male; Methylcholanthrene; Oleandomycin; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin | 1983 |
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver.
Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Triazoles | 1983 |
Induction of liver microsomal 2-hydroxylation of estradiol 17-sulfate by phenobarbital in male rat.
Topics: Animals; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 Enzyme System; Estradiol; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
[Effect of pyrazolone derivatives on the level of reduced glutathione in rat liver].
Topics: Aminopyrine; Animals; Antipyrine; Cobalt; Female; Glutathione; Liver; Male; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1983 |
Neural asymmetry in male fiddler crabs.
Topics: Animals; Axons; Brachyura; Cobalt; Efferent Pathways; Female; Functional Laterality; Ganglia; Male; Motor Neurons | 1983 |
[Acute toxicity and hematological and serum changes caused by various cobalt salts in rats].
Topics: Animals; Cobalt; Female; Hematologic Diseases; Lethal Dose 50; Male; Rats; Rats, Inbred Strains | 1983 |
GABA and glycine effects on the bipolar cells of the carp retina.
Topics: Animals; Carps; Cobalt; Dark Adaptation; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Membrane Potentials; Nerve Endings; Neurons; Photic Stimulation; Retina | 1983 |
Effect of NiCl2, CoCl2 & cycloheximide on microsomal drug metabolism & ALA-synthetase during thiodemeton toxicity.
Topics: 5-Aminolevulinate Synthetase; Animals; Aryl Hydrocarbon Hydroxylases; Cobalt; Cycloheximide; Disulfoton; Drug Interactions; Electron Transport; Ethylmorphine-N-Demethylase; Insecticides; Male; Microsomes, Liver; Nickel; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains | 1983 |
Functional responses of the rat hepatic endoplasmic reticulum to treatment proposed as a model for cholestasis.
Topics: Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Cobalt; Disease Models, Animal; Endoplasmic Reticulum; Hypertrophy; Lipoproteins; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Triglycerides | 1983 |
Study on in vivo and in vitro metabolism of dimethylformamide in male and female rats.
Topics: Aminopyrine; Animals; Biotransformation; Cobalt; Dimethylformamide; Drug Interactions; Female; Formamides; Injections, Intraperitoneal; Liver; Male; Microsomes; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1984 |
In vivo lipid peroxidation in rat brain following intracortical Fe2+ injection.
Topics: Animals; Brain; Cobalt; Ferrous Compounds; Iron; Lipid Peroxides; Male; Rats; Rats, Inbred Strains; Sodium Chloride; Spectrometry, Fluorescence | 1984 |
An investigation of the involvement of calcium in the control of prolactin secretion: studies with low calcium, methoxyverapamil, cobalt and manganese.
Topics: Animals; Calcium; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Gallopamil; Male; Manganese; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Verapamil | 1984 |
Isolation from rat liver of a peroxisomal enzyme which converts molecular form 1 of biliverdin reductase into molecular form 3.
Topics: Animals; Chromatography, DEAE-Cellulose; Cobalt; Female; Liver; Microbodies; NAD; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Inbred Strains | 1984 |
The specificity of biliverdin reductase. The reduction of biliverdin XIII isomers.
Topics: Animals; Bilirubin; Biliverdine; Cobalt; Isoenzymes; Kinetics; Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Substrate Specificity | 1984 |
Lung morphology and phospholipids after experimental inhalation of soluble cadmium, copper, and cobalt.
Topics: Aerosols; Animals; Cadmium; Cadmium Chloride; Cobalt; Copper; Lung; Macrophages; Male; Microscopy, Electron; Nickel; Phospholipids; Pulmonary Alveoli; Rabbits | 1984 |
Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides.
Topics: Animals; Cadmium; Cadmium Chloride; Cobalt; Copper; Lung; Macrophages; Male; Mucous Membrane; Muramidase; Nickel; Rabbits | 1984 |
Antimutagenic action of cobaltous chloride on Trp-P-1-induced mutations in Salmonella typhimurium TA98 and TA1538.
Topics: Carbolines; Cobalt; Genetic Code; Mutagenicity Tests; Mutagens; Mutation; Salmonella typhimurium; Transcription, Genetic | 1982 |
Cobalt mapping of the nervous system: how to avoid artifacts.
Topics: Animals; Axons; Cobalt; Female; Grasshoppers; Histological Techniques; Male; Motor Neurons; Nickel; Thoracic Nerves | 1982 |
Effect of cobaltous chloride on spontaneous mutation induction in a Bacillus subtilis mutator strain.
Topics: Bacillus subtilis; Cobalt; Mutagenicity Tests; Mutagens | 1981 |
Effects of piperonyl butoxide on cephalosporin nephrotoxicity in the rabbit. An effect on cephaloridine transport.
Topics: Acute Kidney Injury; Animals; Biological Transport; Cephaloglycin; Cephaloridine; Cephalosporins; Cobalt; Female; In Vitro Techniques; Kidney Cortex; Kidney Tubular Necrosis, Acute; Mixed Function Oxygenases; Oxidoreductases; Piperonyl Butoxide; Rabbits | 1983 |
Bis (2,3-dibromopropyl) phosphate nephrotoxicity: effect of sex and CoCl2 pretreatment.
Topics: Animals; Cobalt; Creatinine; Drug Interactions; Female; Kidney; Kidney Cortex; Male; Necrosis; Organophosphates; Organophosphorus Compounds; Rats; Sex Factors | 1983 |
Activity of cells in area 17 of the cat in absence of input from layer a of lateral geniculate nucleus.
Topics: Animals; Cats; Cobalt; Geniculate Bodies; Neurons | 1983 |
[Rate of elimination of cobalt from the body of rats depending on the diet].
Topics: Animals; Cobalt; Diet; Food, Fortified; Male; Metabolic Clearance Rate; Rats; Time Factors; Vegetables | 1983 |
Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cinnarizine; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Flunarizine; Guinea Pigs; Ileum; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Pyridines; Structure-Activity Relationship; Verapamil | 1983 |
Effects of cobalt chloride and cycloheximide on the hepatic microsomal enzyme system and biliary excretion rate in control and phenobarbital-pretreated rats.
Topics: Animals; Bile; Bromcresol Green; Cobalt; Cycloheximide; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Sleep | 1983 |
Differential responses to inducers of delta-aminolaevulinate synthase and haem oxygenase during pregnancy.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Enzyme Induction; Female; Heme Oxygenase (Decyclizing); Liver; Microsomes, Liver; Mixed Function Oxygenases; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains | 1981 |
[Contact urticaria to cobalt chloride - comparison of urticarial response between open patch test and scratch test (author's transl)].
Topics: Adult; Cobalt; Dermatitis, Contact; Female; Humans; Male; Patch Tests; Skin Tests; Urticaria | 1981 |
Mutagenic activation of 2,4-diaminoanisole and 2-amino-fluorene by isolated rat liver nuclei and microsomes.
Topics: Animals; Anisoles; Benzoflavones; beta-Naphthoflavone; Cell Nucleus; Cobalt; Flavonoids; Fluorenes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mutagens; NADP; Phenobarbital; Phenylenediamines; Rats; Salmonella typhimurium | 1980 |
Removal of the Schwann sheath from the giant nerve fiber of the squid: an electron-microscopic study of the axolemma and associated axoplasmic structures.
Topics: Animals; Axons; Cobalt; Cytological Techniques; Cytoplasm; Decapodiformes; Fixatives; Intracellular Membranes; Microscopy, Electron; Microscopy, Electron, Scanning; Myelin Sheath | 1981 |
Production of deferriferrioxamines B and E from a ferroverdin-producing Streptomyces species.
Topics: Chlorides; Cobalt; Culture Media; Deferoxamine; Ferric Compounds; Ferrous Compounds; Iron Chelating Agents; Nitroso Compounds; Peptides, Cyclic; Phenols; Streptomyces | 1982 |
Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor.
Topics: Animals; Atractyloside; Benzoflavones; beta-Naphthoflavone; Cobalt; Cysteine; Glycosides; Kidney Tubules; Lethal Dose 50; Liver; Male; Maleates; Phenobarbital; Phenylbutazone; Piperonyl Butoxide; Plants, Toxic; Rats; Rats, Inbred Strains; Stanozolol | 1982 |
Surface electrical activity from Schistosoma mansoni: a sensitive measure of drug action.
Topics: Animals; Autonomic Agents; Calcium; Carbachol; Cobalt; Culture Media; Dopamine; Male; Membrane Potentials; Pentobarbital; Schistosoma mansoni; Serotonin; Sodium Chloride; Trichlorfon | 1982 |
Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin.
Topics: Animals; Cells, Cultured; Chick Embryo; Cobalt; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Liver; Male; Microsomes, Liver; Porphyrins; Proteins; Protoporphyrins; Rats; Rats, Inbred Strains | 1982 |
Formation of malonaldehyde and focal brain edema induced by subpial injection of FeCl2 into rat isocortex.
Topics: Animals; Body Fluids; Brain Edema; Cerebral Cortex; Cobalt; Ferrous Compounds; Injections; Iron; Male; Malonates; Malondialdehyde; Pia Mater; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Modulation of pulmonary p-nitroanisole O-demethylase by intratracheally instilled heavy metal salts.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cadmium; Cadmium Chloride; Cobalt; Intubation, Intratracheal; Lung; Male; Metals; Nickel; Nitroanisole O-Demethylase; Oxidoreductases; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Studies on the metabolism of dimethylnitrosamine in vitro by rat-liver preparations. III. Effect of cobaltous chloride treatment.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Dimethylnitrosamine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Monoamine Oxidase; Rats; Rats, Inbred Strains; Substrate Specificity | 1982 |
Identification of two urinary metabolites of rats treated with acrylonitrile; influence of several inhibitors on the mutagenicity of those urines.
Topics: Acetates; Acetonitriles; Acrylonitrile; Animals; Cobalt; Ethanol; Male; Models, Chemical; Mutagens; Nitriles; Proadifen; Pyrazoles; Rats | 1981 |
The effects of cobalt chloride on the formation of blood lipid peroxide related to glutathione peroxidase in the erythrocytes of rabbits.
Topics: Animals; Cobalt; Erythrocytes; Glutathione Peroxidase; Hemolysis; Lipid Peroxides; Male; Malondialdehyde; Peroxidases; Rabbits | 1980 |
The hypertriglyceridaemia of the cobalt chloride-treated rat: a possible mechanism.
Topics: Animals; Cholesterol; Cobalt; Disease Models, Animal; Fatty Acids, Nonesterified; Hyperlipoproteinemia Type IV; Lipids; Lipoprotein Lipase; Liver; Male; Organ Size; Rats; Triglycerides | 1981 |
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; Male; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Pregnancy; Proadifen | 1981 |
Petechial reaction following patch testing with cobalt.
Topics: Cobalt; Female; Humans; Male; Patch Tests; Purpura; Skin Tests | 1980 |
Non-linear kinetics of microsomal styrene monooxygenase after phenobarbital pre-treatment.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Styrenes | 1980 |
The contact allergens nickel chloride and cobalt chloride directly induce expression of endothelial adhesion molecules.
Topics: Allergens; Cell Adhesion Molecules; Cell Membrane; Cells, Cultured; Cobalt; Dermatitis, Contact; E-Selectin; Endothelium, Vascular; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1; Male; Nickel; Skin; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1993 |
Genotoxic activities in vivo of cobaltous chloride and other metal chlorides as assayed in the Drosophila wing spot test.
Topics: Animals; Chlorides; Cobalt; Crossing Over, Genetic; Drosophila melanogaster; Larva; Manganese Compounds; Manganese Poisoning; Molybdenum; Mutagenicity Tests; Mutagens; Nickel; Zinc Compounds | 1994 |
Cytochrome P450-dependent arachidonate metabolites affect renal transport in the rabbit.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cobalt; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; Loop of Henle; Rabbits | 1993 |
Biodistributions of radioactive bipositive metal ions in tumor-bearing animals.
Topics: Animals; Chlorides; Cobalt; Cobalt Radioisotopes; Liver; Liver Neoplasms, Experimental; Male; Metals; Mice; Neoplasm Transplantation; Palladium; Radioisotopes; Rats; Sarcoma, Yoshida; Staining and Labeling; Strontium; Strontium Radioisotopes; Tissue Distribution; Zinc Compounds; Zinc Radioisotopes | 1994 |
IL-2 induces vasopressin release from the hypothalamus and the amygdala: role of nitric oxide-mediated signaling.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Amygdala; Animals; Antimutagenic Agents; Arginine Vasopressin; Cobalt; Dose-Response Relationship, Drug; Hypothalamus; In Vitro Techniques; Interleukin-2; Male; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley | 1994 |
Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt.
Topics: Antioxidants; Base Sequence; Cell Adhesion Molecules; Cells, Cultured; Cobalt; Dermatitis, Contact; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; Haptens; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Molecular Sequence Data; NF-kappa B; Nickel; Pyrrolidines; Thiocarbamates; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1995 |
Pressure corrections for CoCl2 as a thermometer in an analytic ultracentrifuge.
Topics: Cobalt; Data Interpretation, Statistical; Pressure; Spectrophotometry; Thermometers; Ultracentrifugation | 1995 |
Purification and characterization of a dipeptidase from Lactobacillus sake.
Topics: Amino Acid Sequence; Chlorides; Cobalt; Dipeptidases; Dipeptides; Edetic Acid; Isoelectric Point; Lactobacillus; Manganese Compounds; Meat Products; Molecular Weight; Phenanthrolines; Substrate Specificity | 1995 |
Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells.
Topics: Animals; Cadmium; Cadmium Chloride; Carrier Proteins; Cell Line; Cells, Cultured; Chlorides; Cobalt; Cytosol; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Heme-Binding Proteins; Hemeproteins; Kinetics; Liver; Liver Neoplasms, Experimental; Mice; Molecular Sequence Data; Rats; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Role of ventrolateral medulla in reflex cardiovascular responses to activation of skin and muscle nerves.
Topics: Afferent Pathways; Animals; Blood Pressure; Cobalt; Electric Stimulation; Electrocardiography; Functional Laterality; Heart Rate; Male; Medulla Oblongata; Microelectrodes; Muscle, Skeletal; Neurons; Rats; Rats, Wistar; Skin; Sural Nerve; Tibial Nerve; Time Factors | 1995 |
Glass wool-H2O2/CoCl2 test system for in vitro evaluation of biodegradative stress cracking in polyurethane elastomers.
Topics: Biodegradation, Environmental; Cobalt; Equipment Failure; Glass; Hydrogen Peroxide; Microscopy, Electron, Scanning; Oxidation-Reduction; Oxygen; Polyurethanes; Reproducibility of Results; Stress, Mechanical; Temperature; Tensile Strength | 1995 |
Calcium potentiates cyclic AMP stimulation of pineal arylalkylamine N-acetyltransferase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arylamine N-Acetyltransferase; Bucladesine; Calcimycin; Calcium; Cells, Cultured; Cobalt; Cyclic AMP; Drug Synergism; Female; Norepinephrine; Organ Culture Techniques; Phenylephrine; Pineal Gland; Rats; Rats, Sprague-Dawley | 1993 |
Inhibition and induction of SOS responses in Escherichia coli by cobaltous chloride.
Topics: Antimutagenic Agents; Bacterial Proteins; Cobalt; Escherichia coli; Kinetics; Lysogeny; Magnesium; SOS Response, Genetics | 1993 |
Neuronal mapping studies on the central nervous system of the pulmonate snail Helisoma trivolvis.
Topics: Animals; Axonal Transport; Cobalt; Nervous System; Neurons; Snails | 1993 |
Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial
Topics: Capillaries; Cell Adhesion; Cell Adhesion Molecules; Cobalt; Dermatitis, Contact; E-Selectin; Endothelium; Endothelium, Vascular; Haptens; Humans; Intercellular Adhesion Molecule-1; Male; Nickel; Protein Kinase Inhibitors; Surface Properties; Tachyphylaxis; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 1993 |
Organization of the commissural fibers in the adult brain of the locust.
Topics: Animals; Brain; Brain Chemistry; Cobalt; Gallic Acid; Grasshoppers; Immunohistochemistry; Nerve Fibers; Neural Pathways; Osmium Tetroxide; Serotonin; Staining and Labeling; Terminology as Topic | 1993 |
Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized.
Topics: Animals; Apoptosis; Aurintricarboxylic Acid; Bleomycin; Cell Death; Cell Line; Cobalt; Cricetinae; Cycloheximide; DNA; DNA Damage; Egtazic Acid; Electric Stimulation; Electrophoresis, Agar Gel; Ferrous Compounds; Flow Cytometry; G2 Phase; Humans; Microscopy, Electron; Permeability; Tumor Cells, Cultured | 1993 |
Kinetics and specificity of nickel hypersensitivity in the murine model.
Topics: Animals; Animals, Newborn; Chlorides; Chromium Compounds; Cobalt; Copper; Copper Sulfate; Cross Reactions; Dermatitis, Allergic Contact; Dose-Response Relationship, Immunologic; Drug Eruptions; Female; Irritants; Male; Mice; Mice, Inbred C3H; Nickel; Sensitivity and Specificity; Sex Factors | 1994 |
Lipid peroxidation and chemiluminescence during naproxen metabolism in rat liver microsomes.
Topics: Animals; Antimutagenic Agents; Antioxidants; Ascorbic Acid; Cobalt; Electrophoresis, Polyacrylamide Gel; Ferrous Compounds; Histidine; Lipid Peroxidation; Luminescent Measurements; Magnesium Chloride; Male; Microsomes, Liver; Molecular Weight; NADP; Naproxen; Piperonyl Butoxide; Proadifen; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Vitamin E | 1994 |
Patch test results with serial dilutions of nickel sulfate (with and without detergent), palladium chloride, and nickel and palladium metal plates.
Topics: Adult; Aged; Aged, 80 and over; Alkanesulfonic Acids; Cobalt; Dermatitis, Allergic Contact; Detergents; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nickel; Palladium; Patch Tests; Potassium Dichromate | 1995 |
Ear piercing, and nickel and cobalt sensitization, in 520 young Swedish men doing compulsory military service.
Topics: Adolescent; Adult; Cobalt; Dermatitis, Allergic Contact; Ear, External; Eczema; Hand Dermatoses; Humans; Male; Metals; Military Personnel; Nickel; Patch Tests; Prevalence; Punctures; Smoking; Switzerland | 1995 |
Stimulation of intracellular calcium concentration by adenosine triphosphate and uridine 5'-triphosphate in human term placental cells: evidence for purinergic receptors.
Topics: Adenosine Triphosphate; Calcium; Calcium Channels; Cells, Cultured; Cobalt; Female; Humans; Ion Channel Gating; Kinetics; Nickel; Nifedipine; Pertussis Toxin; Placenta; Pregnancy; Receptors, Purinergic P2; Terpenes; Thapsigargin; Trophoblasts; Uridine Triphosphate; Virulence Factors, Bordetella | 1995 |
Mode of action of an inhibitory neuropeptide SchistoFLRFamide on the locust oviduct visceral muscle.
Topics: Amino Acid Sequence; Animals; Caffeine; Calcimycin; Calcium; Calcium Channels; Cobalt; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Female; Grasshoppers; Ion Channel Gating; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neuropeptides; Nifedipine; Oviducts; Tetradecanoylphorbol Acetate | 1995 |
Chromogranin A applied to the nucleus accumbens decreases locomotor activity induced by activation of the mesolimbic dopaminergic system in the rat.
Topics: Animals; Chromogranin A; Chromogranins; Cobalt; Dopamine; Limbic System; Male; Motor Activity; Nucleus Accumbens; Picrotoxin; Rats; Rats, Wistar; Stereotyped Behavior | 1994 |
Cross-reactivity to metal compounds studied in guinea pigs induced with chromate or cobalt.
Topics: Animals; Cobalt; Cross Reactions; Dermatitis, Allergic Contact; Female; Guinea Pigs; Intradermal Tests; Nickel; Palladium; Potassium Dichromate; Rhodium | 1994 |
A peroxidative model of human erythrocyte intracellular Ca2+ changes with in vivo cell aging: measurement by 19F-NMR spectroscopy.
Topics: Adult; Calcium; Carbon Monoxide; Cell Membrane; Cells, Cultured; Cobalt; Erythrocyte Aging; Erythrocytes; Humans; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Masoprocol; Membrane Proteins; Oxidative Stress | 1995 |
Purification and characterization of hypoxia-inducible factor 1.
Topics: Base Sequence; Cell Line; Chromatography, Affinity; Chromatography, Ion Exchange; Cobalt; DNA; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Oligodeoxyribonucleotides; Transcription Factors | 1995 |
Degradation of heme IX in rats pretreated with cobaltous chloride. A study in isolated perfused liver.
Topics: Animals; Bile; Bilirubin; Cobalt; Glucuronosyltransferase; Heme; In Vitro Techniques; Liver; Male; Molecular Structure; Perfusion; Rats; Rats, Wistar; Reference Values | 1994 |
Cobaltous chloride-mediated induction of rat hepatic tryptophan 2,3-dioxygenase: implications for the use of the enzyme to probe the hepatic free heme pool.
Topics: Adrenal Glands; Adrenalectomy; Animals; Apoenzymes; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Liver; Male; Metals; Rats; Rats, Sprague-Dawley; Tryptophan Oxygenase | 1994 |
Differential inhibition by iodonium compounds of induced erythropoietin expression.
Topics: Biphenyl Compounds; Cobalt; Erythropoietin; Onium Compounds; Tumor Cells, Cultured | 1995 |
Metal allergy in north Norwegian schoolchildren and its relationship with ear piercing and atopy.
Topics: Child; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dermatitis, Irritant; Ear, External; Female; Humans; Irritants; Male; Metals; Nickel; Norway; Patch Tests; Potassium Dichromate; Punctures; Reproducibility of Results; Sensitivity and Specificity; Sex Factors | 1994 |
Erosive oral lichen planus due to sensitization to cobalt chloride.
Topics: Cobalt; Dental Prosthesis; Female; Humans; Lichen Planus, Oral; Middle Aged | 1994 |
Modulation of the respiratory responses to hypoxia and hypercapnia by synaptic input onto caudal hypothalamic neurons.
Topics: Animals; Cobalt; gamma-Aminobutyric Acid; Heart; Hypercapnia; Hypothalamus; Hypoxia; Male; Neurons; Rats; Rats, Sprague-Dawley; Respiration; Synaptic Transmission | 1994 |
Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.
Topics: Anemia; Animals; Cells, Cultured; Cobalt; Endothelial Growth Factors; Endothelium, Vascular; Fibroblasts; Gene Expression; Hypoxia; Isomerism; Lymphokines; Male; Nucleic Acid Hybridization; Rats; Rats, Wistar; Ribonucleases; RNA, Messenger; Tissue Distribution; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1994 |
Effect of acute and chronic cobalt administration on carotid body chemoreceptors responses.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cobalt; Injections, Intra-Arterial; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley | 1994 |
Cobalt and possible oxidant-mediated toxicity.
Topics: Animals; Cobalt; Cricetinae; Glutathione; Humans; Lung; Lung Diseases; Occupational Diseases; Pentose Phosphate Pathway | 1994 |
Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tracer in focal cerebral ischaemia.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebrovascular Circulation; Cobalt; Drug Stability; Organotechnetium Compounds; Oximes; Reagent Kits, Diagnostic; Technetium Tc 99m Exametazime; Time Factors; Tomography, Emission-Computed, Single-Photon | 1994 |
Creep of a poly(etherurethane urea) in an oxidative environment.
Topics: Biocompatible Materials; Biodegradation, Environmental; Chromatography, Gas; Cobalt; Crystallization; Hydrogen Peroxide; Molecular Weight; Oxidation-Reduction; Polyurethanes; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1994 |
Serotonin and its requirement for maintenance of contractility in muscle fibres isolated from Schistosoma mansoni.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antimony Potassium Tartrate; Calcium; Cobalt; Colforsin; Culture Media; Dose-Response Relationship, Drug; Muscle Contraction; Nicardipine; Potassium; Protein Kinase Inhibitors; Schistosoma mansoni; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cloning, Molecular; Cobalt; Cyanides; Cycloheximide; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Isoenzymes; L Cells; L-Lactate Dehydrogenase; Liver Neoplasms; Mice; Molecular Sequence Data; Oxygen; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sequence Deletion; Sequence Homology, Nucleic Acid; TATA Box; Transfection; Tumor Cells, Cultured | 1994 |
Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid culture.
Topics: Cells, Cultured; Cobalt; Cytochromes; Erythropoietin; Hydrogen Peroxide; Oxidation-Reduction; Signal Transduction | 1994 |
Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage.
Topics: Animals; Bilirubin; Cobalt; Enzyme Induction; Female; Glutathione; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Liver; Luminescent Measurements; Oxidants; Rats; Rats, Wistar | 1994 |
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase.
Topics: Animals; Bone and Bones; Bone Morphogenetic Protein 1; Bone Morphogenetic Proteins; Cadmium; Cadmium Chloride; Chick Embryo; Chlorides; Cobalt; Copper; Endopeptidases; Kinetics; Mercury; Metalloendopeptidases; Nickel; Procollagen N-Endopeptidase; Protease Inhibitors; Sternum; Tendons; Zinc Compounds | 1994 |
Attempts to mimic the repeated open application test in the guinea pig.
Topics: Administration, Cutaneous; Allergens; Animals; Cobalt; Dermatitis, Allergic Contact; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Female; Guinea Pigs; Models, Biological; Patch Tests; Pilot Projects; Reaction Time; Time Factors | 1994 |
Effects of chronic hypoxia and cobalt on macroprotein pattern in the rabbit carotid body and superior cervical ganglion: preliminary observations.
Topics: Animals; Blotting, Northern; Carotid Body; Cobalt; Electrophoresis, Polyacrylamide Gel; Hypoxia; Molecular Weight; Nerve Tissue Proteins; Rabbits; Reference Values; Superior Cervical Ganglion | 1993 |
Calcium channel blockers modify electrophysiological effects induced by lytic granules from cytotoxic T lymphocytes in guinea pig ventricular myocytes.
Topics: Action Potentials; Animals; Cadmium; Cadmium Chloride; Calcium Channel Blockers; Chlorides; Cobalt; Cytoplasmic Granules; Cytotoxicity, Immunologic; Guinea Pigs; Heart; Heart Ventricles; Hemolysis; In Vitro Techniques; Nisoldipine; T-Lymphocytes, Cytotoxic; Verapamil | 1994 |
Ethylene is a selective ribosomal cistron regulator in Allium cepa epidermal cells.
Topics: Allium; Cell Nucleolus; Cobalt; Cycloheximide; Dactinomycin; Ethylenes; Genes; Genes, Plant; Nucleolus Organizer Region; Ribosomes; Silver Nitrate | 1993 |
The effects of simultaneous alcohol and cobalt chloride administration on the cardiovascular system of rats.
Topics: Animals; Blood Circulation; Cardiovascular System; Cobalt; Ethanol; Heart; Hemodynamics; Male; Rats; Rats, Inbred Strains | 1993 |
Cobalt(II) and nickel(II) ions as promoters of free radicals in vivo: detected directly using electron spin resonance spectrometry in circulating blood in rats.
Topics: Animals; Ascorbic Acid; Cobalt; Electron Spin Resonance Spectroscopy; Free Radicals; Male; Nickel; Rats; Rats, Sprague-Dawley | 1993 |
Analysis of rapid calcium signals in synaptosomes.
Topics: Animals; Cadmium; Cadmium Chloride; Calcium; Cerebral Cortex; Chlorides; Cobalt; Kinetics; Membrane Potentials; Potassium Chloride; Rats; Rats, Sprague-Dawley; Signal Transduction; Synaptosomes; Time Factors | 1993 |
Contribution of bed nucleus of the stria terminalis to the cardiovascular responses elicited by stimulation of the amygdala.
Topics: Amygdala; Animals; Blood Pressure; Cobalt; Electric Stimulation; Electrodes; Fluorescent Dyes; Heart Rate; Hemodynamics; Histocytochemistry; Ibotenic Acid; Male; Microspheres; Rats; Rats, Wistar; Rhodamines; Stilbamidines; Stimulation, Chemical; Synapses; Thalamic Nuclei | 1993 |
Effects of sodium fluoride and cobalt chloride on the enantioselectivity of microsomal and cytosolic esterases in rat intestinal mucosa.
Topics: Animals; Cobalt; Cytosol; Dose-Response Relationship, Drug; Esterases; Intestinal Mucosa; Male; Microsomes; Oxazepam; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Stereoisomerism | 1993 |
Involvement of adenosine-sensitive cyclic AMP-generating systems in cobalt-induced epileptic activity in the rat.
Topics: 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Cerebral Cortex; Cobalt; Cyclic AMP; Electroencephalography; Epilepsy; In Vitro Techniques; Male; Microinjections; Motor Activity; Rats; Rats, Wistar; Theophylline | 1993 |
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
Topics: Base Sequence; Cell Hypoxia; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Oligonucleotide Probes; RNA, Neoplasm; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1993 |
Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat.
Topics: Animals; Body Weight; Cobalt; Drug Synergism; Fungicides, Industrial; Injections, Intraperitoneal; Kidney; Male; Microsomes; Organ Size; Phenobarbital; Piperonyl Butoxide; Proteinuria; Rats; Rats, Inbred F344; Succinimides | 1993 |
High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells.
Topics: 3-Mercaptopropionic Acid; Adult; Animals; Blotting, Northern; Cell Membrane; Cells, Cultured; Cobalt; Endothelium, Vascular; GPI-Linked Proteins; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Male; Metalloendopeptidases; Precipitin Tests; Pulmonary Alveoli; Rats; Species Specificity; Swine | 1993 |
Periodontal attachment loss assessed by linear and area measurements in vitro.
Topics: Alveolar Bone Loss; Analysis of Variance; Chi-Square Distribution; Cobalt; Copper; Diagnosis, Oral; Humans; Odontometry; Periodontal Diseases; Periodontal Ligament; Spectrophotometry, Atomic; Tooth Root | 1993 |
Isolated cobalt sensitivity in an etcher.
Topics: Adult; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Humans; Metallurgy; Patch Tests | 1993 |
Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.
Topics: Carcinoma, Hepatocellular; Cobalt; Erythropoietin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Humans; Liver Neoplasms; Metalloporphyrins; Protoporphyrins; RNA, Messenger; Tumor Cells, Cultured | 1993 |
The binding of terbium ions to tubulin induces ring formation.
Topics: Animals; Brain; Chickens; Chlorides; Cobalt; Kinetics; Macromolecular Substances; Magnesium; Manganese; Manganese Compounds; Microscopy, Electron; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Terbium; Tubulin; Zinc; Zinc Compounds | 1993 |
Contribution of caudal ventrolateral medulla to the cardiovascular responses elicited by activation of bed nucleus of the stria terminalis.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Cobalt; Glutamates; Heart Rate; Limbic System; Male; Medulla Oblongata; Prosencephalon; Rats; Rats, Wistar | 1993 |
K+ currents in rabbit esophageal muscularis mucosae.
Topics: Animals; Calcium; Cell Membrane; Cobalt; Esophagus; In Vitro Techniques; Membrane Potentials; Mucous Membrane; Muscle, Smooth; Potassium; Potassium Channels; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds | 1993 |
Regulation of collagen synthesis in human dermal fibroblasts in contracted collagen gels by ascorbic acid, growth factors, and inhibitors of lipid peroxidation.
Topics: 2,2'-Dipyridyl; Ascorbic Acid; Cells, Cultured; Cobalt; Collagen; Dose-Response Relationship, Drug; Ethanol; Fibroblast Growth Factors; Fibroblasts; Gels; Growth Substances; Humans; Infant, Newborn; Kinetics; Lipid Peroxidation; Mannitol; Propyl Gallate; Skin; Time Factors; Transforming Growth Factor beta; Tretinoin; Vitamin A | 1993 |
Stabilisation of high-activity 99mTc-d,l-HMPAO preparations with cobalt chloride and their biological behaviour.
Topics: Animals; Brain; Cobalt; Drug Stability; Erythrocytes; Humans; Male; Mice; Organotechnetium Compounds; Oximes; Papio; Radionuclide Imaging; Reagent Kits, Diagnostic; Technetium Tc 99m Exametazime; Time Factors; Tissue Distribution | 1995 |
Hypoxic induction of gene expression in chronic granulomatous disease-derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase.
Topics: B-Lymphocytes; Base Sequence; Biomarkers; Cell Hypoxia; Cell Line, Transformed; Cobalt; Cytochrome b Group; Endothelial Growth Factors; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Lymphokines; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidase 2; NADPH Oxidases; Oxygen; Partial Pressure; Phosphoproteins; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1996 |
Is the European standard series suitable for patch testing in Riyadh, Saudi Arabia?
Topics: Adolescent; Adult; Aged; Allergens; Anesthetics, Local; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Benzocaine; Benzoquinones; Child; Cobalt; Europe; Evaluation Studies as Topic; Female; Formaldehyde; Humans; Irritants; Male; Middle Aged; Neomycin; Nickel; Patch Tests; Perfume; Potassium Dichromate; Saudi Arabia; Sex Factors | 1995 |
Effect of potassium permanganate, cobalt chloride and vitamin B complex on the haematological parameters of cadmium treated common carp, Cyprinus carpio.
Topics: Analysis of Variance; Animals; Blood Cell Count; Blood Sedimentation; Cadmium; Carps; Cobalt; Hematocrit; Hemoglobins; Potassium Permanganate; Vitamin B Complex | 1995 |
Endoplasmic reticulum proliferates without an increase in cytochrome P-450 in hepatocytes of mice treated with phenobarbital and cobalt chloride.
Topics: Animals; Cells, Cultured; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Liver; Male; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Phospholipids | 1995 |
Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells.
Topics: Animals; Cells, Cultured; Chick Embryo; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cobalt; Gene Expression Regulation, Neoplastic; Hemeproteins; Humans; Iron; Kinetics; Liver Neoplasms; Nickel; RNA, Messenger; Time Factors; Transcription, Genetic; Transferrin; Tumor Cells, Cultured | 1996 |
[Comparative studies on freeze dryers of one and two chamber systems].
Topics: Cobalt; Dextrans; Equipment Design; Freeze Drying; Mannitol | 1996 |
Expression of the Fanconi anemia gene FAC in human cell lines: lack of effect of oxygen tension.
Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Hypoxia; Cell Line, Transformed; Cobalt; DNA-Binding Proteins; Erythropoietin; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphocytes; Nuclear Proteins; Oxygen; Protein Biosynthesis; Proteins; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Roles of calcium and calmodulin in the mediation of acute and sustained GnRH-stimulated gonadotropin secretion from dispersed goldfish pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cobalt; Culture Media; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Pituitary Gland | 1996 |
The effect of cobalt chloride on skin flap survival.
Topics: Animals; Cobalt; Glutathione Peroxidase; Glutathione Reductase; Graft Survival; Lipid Peroxidation; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Skin; Skin Transplantation; Surgical Flaps | 1996 |
A non-invasive vibrating calcium-selective electrode measures acetylcholine-induced calcium flux across the sarcolemma of a smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Cobalt; Diltiazem; Ion Transport; Lanthanum; Lithium; Microelectrodes; Muscle Contraction; Muscle, Smooth; Sarcolemma; Sea Cucumbers; Verapamil | 1996 |
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cytochrome P-450 CYP1A1; Dioxins; DNA-Binding Proteins; Female; Genes, Reporter; HeLa Cells; Helix-Loop-Helix Motifs; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Luciferases; Male; Mutagenesis; Nuclear Proteins; Organ Specificity; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; RNA, Messenger; Sequence Deletion; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
Blockade of glutamate receptors in CVLM and NTS attenuates airway dilation evoked from parabrachial region.
Topics: Airway Resistance; Animals; Blood Gas Analysis; Cats; Cobalt; Electric Stimulation; Excitatory Amino Acid Antagonists; Homocysteine; Kynurenic Acid; Medulla Oblongata; Microinjections; Pons; Solitary Nucleus | 1996 |
Multiple sensitivities to metals.
Topics: Allergens; Austria; Cobalt; Dermatitis, Contact; Humans; Irritants; Metals; Multiple Chemical Sensitivity; Nickel; Palladium; Potassium Dichromate | 1996 |
Cobalt but not hypoxia stimulates PDGF gene expression in rats.
Topics: Administration, Cutaneous; Animals; Antimutagenic Agents; Cobalt; Gene Expression Regulation; Hypoxia; Male; Organ Specificity; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley | 1996 |
Lateral tegmental field neurons sensitive to muscular contraction: a role in pressor reflexes?
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cats; Central Nervous System Depressants; Cobalt; Electric Stimulation; Hypothalamus, Posterior; Lidocaine; Microinjections; Muscle Contraction; Neurons; Phenylephrine; Pressoreceptors; Respiratory Mechanics; Respiratory Muscles; Sympathetic Nervous System; Tegmentum Mesencephali | 1996 |
Distribution of nickel and cobalt following dermal and systemic administration with in vitro and in vivo studies.
Topics: 3T3 Cells; Administration, Cutaneous; Animals; Biological Transport; Cell Line; Cobalt; Cricetinae; Dermatitis, Contact; Female; Humans; Injections, Intramuscular; Keratinocytes; L Cells; Mesocricetus; Mice; Nickel | 1996 |
Effect of melatonin, piperonyl butoxide, or cobalt chloride on L-cysteine-induced lipid peroxidation in homogenate from whole brain of mice.
Topics: Animals; Brain; Cobalt; Cysteine; Enzyme Inhibitors; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Mice; Mixed Function Oxygenases; Piperonyl Butoxide; Xanthine Oxidase | 1996 |
Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.
Topics: Adrenocorticotropic Hormone; Animals; Central Nervous System; Cobalt; Corticosterone; Glial Fibrillary Acidic Protein; HIV Envelope Protein gp120; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Memantine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Synthase; omega-N-Methylarginine; Pituitary Gland; Pituitary-Adrenal System; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins | 1996 |
In vivo analysis of DNA-protein interactions on the human erythropoietin enhancer.
Topics: Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; DNA; DNA Footprinting; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Genes; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Polymerase Chain Reaction; Trans-Activators; Tumor Cells, Cultured | 1997 |
Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.
Topics: Animals; Antimutagenic Agents; Blood Gas Monitoring, Transcutaneous; Cobalt; Deferoxamine; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucokinase; Hydrogen Peroxide; Insulin; Liver; Male; Rats; Rats, Wistar; RNA, Messenger | 1997 |
Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species.
Topics: Cell Line; Cobalt; Deferoxamine; Erythropoietin; Humans; Hydrogen Peroxide; NADP; Reactive Oxygen Species; Signal Transduction | 1997 |
Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation.
Topics: 3T3 Cells; Animals; Anisomycin; Azides; Base Sequence; Cobalt; Dactinomycin; Gene Expression Regulation; Glucose Transporter Type 1; Mice; Molecular Sequence Data; Monosaccharide Transport Proteins; Oxidative Phosphorylation; Oxygen; Promoter Regions, Genetic; Rats; RNA, Messenger | 1997 |
Medullary pathways mediating depressor responses from Na(+)-sensitive sites in nucleus of the solitary tract.
Topics: Animals; Blood Pressure; Cobalt; Heart Rate; Injections; Male; Medulla Oblongata; Nerve Block; Neural Pathways; Phytohemagglutinins; Rats; Rats, Wistar; Saline Solution, Hypertonic; Sodium; Sodium Chloride; Solitary Nucleus; Synaptic Transmission | 1997 |
Study of persistence and loss of patch test reactions to dichromate and cobalt.
Topics: Adult; Cobalt; Construction Materials; Dermatitis, Allergic Contact; Dermatitis, Occupational; Humans; Lymphocyte Activation; Male; Middle Aged; Patch Tests; Potassium Dichromate; T-Lymphocyte Subsets | 1997 |
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorides; Cobalt; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferric Compounds; Gene Expression Regulation, Enzymologic; Heme; Hemin; Liver; Molecular Weight; Nuclear Proteins; Phenobarbital; Protoporphyrins; Rats; RNA, Messenger; Steroid Hydroxylases; Transcription, Genetic | 1997 |
A study of the behaviour of cobalt chloride during the labelling of leukocytes with 99Tcm-HMPAO stabilised in vitro by the addition of cobalt chloride solution.
Topics: Analysis of Variance; Cell Survival; Cobalt; Cobalt Radioisotopes; Drug Carriers; Drug Stability; Female; Humans; In Vitro Techniques; Leukocytes; Male; Organotechnetium Compounds; Oximes; Polycythemia; Radionuclide Imaging; Technetium Tc 99m Exametazime | 1997 |
Trigeminal autonomic pathways involved in nociception-induced reflex cardiovascular responses.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Cobalt; Electric Stimulation; Functional Laterality; Heart Rate; Incisor; Lidocaine; Male; Mandibular Nerve; Medulla Oblongata; Models, Neurological; Pain; Rats; Rats, Wistar; Reflex; Synaptic Transmission; Trigeminal Nucleus, Spinal | 1997 |
The effect of strain state on the biostability of a poly(etherurethane urea) elastomer.
Topics: Biocompatible Materials; Cobalt; Drug Stability; Hydrogen Peroxide; Kinetics; Microscopy, Electron, Scanning; Polyurethanes; Rubber; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Time Factors | 1997 |
Hypoxia stimulates cytokine production by villous explants from the human placenta.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Cobalt; Culture Techniques; Cytokines; Female; Humans; Immunohistochemistry; Immunosorbent Techniques; Interleukin-1; Interleukin-6; Oxygen; Placenta; Pregnancy; Trophoblasts; Tumor Necrosis Factor-alpha | 1997 |
Renal oxygenases: differential contribution to vasoconstriction induced by ET-1 and ANG II.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Arachidonic Acids; Cobalt; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Endothelin-1; Enzyme Inhibitors; Flavanones; Flavonoids; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasoconstriction | 1997 |
Effect of cobalt chloride on content of lipids and lipoproteins in serum and liver of rats.
Topics: Animals; Cobalt; Lipid Metabolism; Lipid Peroxidation; Lipids; Lipoproteins; Liver; Male; Microsomes, Liver; Rats; Rats, Wistar; Time Factors | 1997 |
Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction.
Topics: Adult; Aging; Cobalt; Cohort Studies; Corpus Luteum; Endothelial Growth Factors; Female; Follicular Fluid; Granulosa Cells; Humans; Hypoxia; Lymphokines; Maternal Age; Middle Aged; Osmolar Concentration; Ovulation Induction; Pregnancy; Pregnancy, High-Risk; Retrospective Studies; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
The intracellular calcium increase at fertilization in Urechis caupo oocytes: activation without waves.
Topics: Ammonium Chloride; Animals; Annelida; Calcium; Cobalt; Female; Fertilization; Fluorescent Dyes; Kinetics; Male; Microscopy, Confocal; Microscopy, Fluorescence; Oocytes; Spermatozoa; Time Factors | 1997 |
Role of protein-phosphorylation events in the anoxia signal-transduction pathway leading to the inhibition of total protein synthesis in isolated hepatocytes.
Topics: Animals; Cell Hypoxia; Cell Survival; Cobalt; Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Protein Kinase Inhibitors; Proteins; Rats; Rats, Wistar; Signal Transduction | 1997 |
Quantification and specificity of the repeated open application test (ROAT). A methodological study using cobalt and colophony in guinea pigs.
Topics: Animals; Antimutagenic Agents; Cobalt; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Patch Tests; Reference Values; Resins, Plant; Sensitivity and Specificity; Tars | 1997 |
Discrimination between the different compartments in sciatic nerve by 2H double-quantum-filtered NMR.
Topics: Animals; Anisotropy; Cartilage; Cobalt; Deuterium; Edetic Acid; Magnetic Resonance Spectroscopy; Myelin Sheath; Peripheral Nerves; Rats; Schwann Cells; Sciatic Nerve | 1997 |
Glycemia-lowering effect of cobalt chloride in the diabetic rat: increased GLUT1 mRNA expression.
Topics: Animals; Blood Glucose; Body Weight; Cobalt; Diabetes Mellitus, Experimental; Drinking; Gene Expression Regulation; Glucose Transporter Type 1; Insulin; Male; Monosaccharide Transport Proteins; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1997 |
Isolation and characterization of heavy metals resistant bacteria from Lagos Lagoon.
Topics: Chlorides; Chromium Compounds; Cobalt; Copper; Gram-Negative Bacteria; Gram-Positive Bacteria; Lead; Mercuric Chloride; Metals, Heavy; Nigeria; Water Microbiology; Zinc Compounds | 1997 |
Cytochrome P-450-derived eicosanoids participate in the renal functional effects of ET-1 in the anesthetized rat.
Topics: Anesthesia, General; Animals; Clotrimazole; Cobalt; Cytochrome P-450 Enzyme System; Eicosanoids; Endothelin-1; Fatty Acids, Monounsaturated; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Circulation; Vascular Resistance | 1998 |
Regulation of vascular endothelial growth factor expression by cAMP in rat aortic smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Aorta; Cobalt; Colforsin; Cyclic AMP; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Fibroblasts; Gene Expression Regulation; Iloprost; Isoproterenol; Lymphokines; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Rats; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells.
Topics: Adrenomedullin; Cobalt; Colorectal Neoplasms; Culture Media; Gene Expression Regulation; Humans; Hypoxia; Ischemia; Peptides; RNA, Messenger; Tumor Cells, Cultured; Vasodilator Agents | 1998 |
Nickel- and cobalt-dependent reagents identify structural features of RNA that are not detected by dimethyl sulfate or RNase T1.
Topics: Animals; Base Sequence; Cobalt; Female; Guanine; In Vitro Techniques; Indicators and Reagents; Magnesium; Molecular Sequence Data; Molecular Structure; Nickel; Nucleic Acid Conformation; Oocytes; Organometallic Compounds; Ribonuclease T1; RNA, Ribosomal, 5S; Sulfuric Acid Esters; Xenopus laevis | 1998 |
Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase.
Topics: Animals; Antidotes; Calcium; Cattle; Cell Hypoxia; Cells, Cultured; Chlorides; Cobalt; Deferoxamine; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Ferrous Compounds; Gene Expression Regulation, Enzymologic; Glyceraldehyde-3-Phosphate Dehydrogenases; Heptanoates; Manganese Compounds; Nickel; Nitric Oxide; Nitroarginine; Nitroprusside; Oxidation-Reduction; RNA, Messenger; Up-Regulation; Zinc Compounds | 1998 |
Immunochemical comparison of 3'-hydroxyacetanilide and acetaminophen binding in mouse liver.
Topics: Acetaminophen; Acetanilides; Allyl Compounds; Animals; Cobalt; Cytochrome P-450 CYP2E1 Inhibitors; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred Strains; Microsomes; Protein Binding; Rats; Sulfides | 1998 |
Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver.
Topics: Animals; Cobalt; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Isoenzymes; Lipopolysaccharides; Liver; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.
Topics: Animals; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mutation; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Leukotriene A4 hydrolase: differential inhibition of the catalytic activities by divalent cations.
Topics: Catalysis; Cations, Divalent; Cobalt; Edetic Acid; Enzyme Activation; Epoxide Hydrolases; Humans; Kinetics; Leukocytes; Zinc Sulfate | 1997 |
The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension.
Topics: Acute Disease; Analysis of Variance; Animals; Cobalt; Culture Techniques; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Hypertension; Immunoblotting; Kidney Cortex; Lithium; Male; Rats; Rats, Sprague-Dawley; Reference Values; Renal Circulation; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Urine | 1998 |
Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Carbon Monoxide; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; DNA-Binding Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Precursors; Gelatinases; Gene Expression Regulation; Hemeproteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphokines; Nuclear Proteins; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcription Factors; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Human hematopoietic progenitors express erythropoietin.
Topics: Adult; Antigens, CD34; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cells, Cultured; Cobalt; Culture Media, Serum-Free; Enzyme-Linked Immunosorbent Assay; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Molecular Sequence Data; Peptides; Receptors, Erythropoietin; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Divalent cobalt as a label to study lymphocyte distribution using PET and SPECT.
Topics: Animals; Calcium Chloride; Cobalt; Cobalt Radioisotopes; Female; Half-Life; Humans; Isotope Labeling; Lymphocytes; Male; Rats; Rats, Wistar; Time Factors; Tissue Distribution; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1998 |
Glycemia-lowering effect of cobalt chloride in the diabetic rat: role of decreased gluconeogenesis.
Topics: Animals; Blood Glucose; Cobalt; Deoxyglucose; Diabetes Mellitus, Experimental; Eye; Fasting; Gluconeogenesis; Hypoglycemic Agents; Kidney; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Sprague-Dawley; RNA, Messenger; Tritium | 1998 |
Hypotension following acute hypovolaemia depends on the caudal midline medulla.
Topics: Acute Disease; Anesthetics, Local; Animals; Blood Pressure; Cobalt; Hemorrhage; Hypotension; Lidocaine; Male; Medulla Oblongata; Plasma Volume; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1998 |
Hypoxia induced by Na2S2O4 increases [Na+]i in mouse glomus cells, an effect depressed by cobalt. Experiments with Na+-selective microelectrodes and voltage-clamping.
Topics: Animals; Antimutagenic Agents; Antioxidants; Aortic Bodies; Barium; Calcium Channel Blockers; Carotid Body; Cobalt; Electric Stimulation; Hypoxia; Ion Channel Gating; Membrane Potentials; Mice; Microelectrodes; Patch-Clamp Techniques; Sodium; Tetrodotoxin; Thiosulfates | 1998 |
Growth hormone-releasing factor mobilizes cytosolic free calcium through different mechanisms in two somatotrope subpopulations from porcine pituitary.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Compartmentation; Cell Separation; Centrifugation, Density Gradient; Chelating Agents; Cobalt; Cytosol; Edetic Acid; Extracellular Space; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Ion Transport; Pituitary Gland, Anterior; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; Signal Transduction; Swine; Thapsigargin; Verapamil | 1998 |
Hypoxia and CYP1A1 induction-dependent regulation of proteins involved in glucose utilization in Caco-2 cells.
Topics: beta-Naphthoflavone; Caco-2 Cells; Cell Hypoxia; Cobalt; Cytochrome P-450 CYP1A1; Enzyme Induction; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Glycogen; Humans; Lactic Acid; Monosaccharide Transport Proteins; RNA, Messenger; Signal Transduction; Sucrase-Isomaltase Complex | 1998 |
Differential xenobiotic induction of CYP2A5 in mouse liver, kidney, lung, and olfactory mucosa.
Topics: Amitrole; Animals; Aryl Hydrocarbon Hydroxylases; Cobalt; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA Probes; Enzyme Induction; Griseofulvin; Immunoblotting; Isoenzymes; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Olfactory Mucosa; Pyrazoles; RNA, Messenger; Substrate Specificity; Thioacetamide; Tin Compounds; Xenobiotics | 1998 |
Chemiluminescence accompanying oxidation of bopindolol.
Topics: Adrenergic beta-Antagonists; Buffers; Cobalt; Edetic Acid; Hydrogen Peroxide; Luminescent Measurements; Molecular Structure; Oxidation-Reduction; Pindolol; Spectrometry, Fluorescence; Spectrophotometry | 1998 |
Purification and characterization of type 1 protein phosphatase from Saccharomyces cerevisiae: effect of the R73C mutation.
Topics: Amino Acid Substitution; Calcium-Calmodulin-Dependent Protein Kinases; Cobalt; Enzyme Activation; Enzyme Inhibitors; Fungal Proteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Mutagenesis, Site-Directed; Phosphoprotein Phosphatases; Protein Phosphatase 1; Saccharomyces cerevisiae; Trypsin | 1998 |
Hypoxia exerts cell-type-specific effects on expression of the class 3 aldehyde dehydrogenase gene.
Topics: Aldehyde Dehydrogenase; Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Down-Regulation; Epithelium, Corneal; Gene Expression Regulation, Enzymologic; L-Lactate Dehydrogenase; Liver Neoplasms, Experimental; Methylcholanthrene; Rats; Receptors, Aryl Hydrocarbon; RNA, Messenger; Tumor Cells, Cultured | 1998 |
The lack of extracellular Na+ exacerbates Ca2+-dependent damage of cultured cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Microscopy, Electron; Rats; Rats, Wistar; Rhodamine 123; Rhodamines; Sodium Chloride | 1998 |
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; CHO Cells; Cobalt; COS Cells; Cricetinae; Cricetulus; Deferoxamine; DNA-Binding Proteins; Endothelial Growth Factors; Gene Expression Regulation; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; L-Lactate Dehydrogenase; Lymphokines; Mice; Mice, Inbred BALB C; Nuclear Proteins; Onium Compounds; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; RNA, Messenger; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
Topics: Adenosine Triphosphate; Antioxidants; Azoles; Cell Hypoxia; Cell Line; Cobalt; DNA-Binding Proteins; DNA, Mitochondrial; Endothelial Growth Factors; Erythropoietin; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Isoindoles; Lymphokines; Mitochondria, Liver; Nuclear Proteins; Organoselenium Compounds; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Thiocarbamates; Transcription Factors; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Metal chloride primers for bonding dentine with tri-n-butylborane-initiated luting agents.
Topics: Acid Etching, Dental; Aluminum Chloride; Aluminum Compounds; Analysis of Variance; Animals; Boron Compounds; Cattle; Cesium; Chlorides; Cobalt; Copper; Dental Bonding; Dental Cements; Dentin; Dentin-Bonding Agents; Ferric Compounds; Immersion; Magnesium Chloride; Metals; Methacrylates; Methylmethacrylate; Methylmethacrylates; Nickel; Phosphoric Acids; Polymers; Stainless Steel; Surface Properties; Tensile Strength; Tin Compounds; Water; Zinc Compounds | 1998 |
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
Topics: Animals; Antimutagenic Agents; Base Sequence; Cell Hypoxia; Chelating Agents; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Erythropoietin; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Lymphokines; Mersalyl; Nuclear Proteins; Phosphopyruvate Hydratase; Rats; Receptor, IGF Type 1; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Volume-evoked micturition reflex is mediated by the ventrolateral periaqueductal gray in anesthetized rats.
Topics: Animals; Brain Mapping; Cobalt; Electromyography; Injections; Male; Periaqueductal Gray; Pons; Pressure; Rats; Rats, Sprague-Dawley; Reflex; Tegmentum Mesencephali; Urinary Bladder; Urination; Urine | 1998 |
Regional and laminar specificity of kainate-stimulated cobalt uptake in the rat hippocampal formation.
Topics: Animals; Calcium; Calcium Channels; Cobalt; Dendrites; Dentate Gyrus; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channels; Ion Transport; Kainic Acid; Kynurenic Acid; Male; Nerve Endings; Nerve Tissue Proteins; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Stimulation, Chemical | 1998 |
Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells.
Topics: Animals; Arginine; Butyrates; Cattle; Cells, Cultured; Cobalt; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression Regulation; Humans; Hydroxamic Acids; Hypoxia; NG-Nitroarginine Methyl Ester; Oxygen; RNA, Messenger; Thrombospondin 1 | 1998 |
Optimal erythropoietin expression in human hepatoma cell lines requires activation of multiple signalling pathways.
Topics: Carcinoma, Hepatocellular; Cell Count; Cell Hypoxia; Cobalt; Dexamethasone; Erythropoietin; Humans; Interleukin-6; Liver Neoplasms; Oxygen; Signal Transduction | 1998 |
Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina.
Topics: Animals; Antimutagenic Agents; Blood-Brain Barrier; Brain Chemistry; Capillaries; Cerebral Cortex; Cobalt; Endothelial Growth Factors; Gene Expression; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypoxia; Lymphokines; Male; Microcirculation; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase.
Topics: Angiogenesis Inducing Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cobalt; Deferoxamine; Deoxyribose; Humans; Neovascularization, Pathologic; Oxygen; Ribosemonophosphates; Stereoisomerism; Thymidine Phosphorylase; Tumor Cells, Cultured | 1998 |
[Skin reactivity in subjects sensitive to different concentrations of nickel, chromium and cobalt].
Topics: Adolescent; Adult; Aged; Cobalt; Female; Humans; Hypersensitivity; Male; Middle Aged; Nickel; Patch Tests; Potassium Dichromate; Retrospective Studies | 1998 |
Source of inappropriate receptive fields in cortical somatotopic maps from rats that sustained neonatal forelimb removal.
Topics: Amputation, Surgical; Animals; Animals, Newborn; Brachial Plexus; Brain Mapping; Cobalt; Electric Stimulation; Forelimb; GABA Antagonists; Hindlimb; Jaw; Phantom Limb; Rats; Reaction Time; Sciatic Nerve; Somatosensory Cortex; Thalamus | 1999 |
Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist.
Topics: Adult; Anemia, Sickle Cell; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; E-Selectin; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes, Abnormal; Flavonoids; HL-60 Cells; Humans; Hypoxia; Indoles; Intercellular Adhesion Molecule-1; Maleimides; Marine Toxins; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; NF-kappa B; Oxazoles; Phospholipid Ethers; Phosphoprotein Phosphatases; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1999 |
The antinociception produced by microinjection of a cholinergic agonist in the ventromedial medulla is mediated by noradrenergic neurons in the A7 catecholamine cell group.
Topics: Anesthetics, Local; Animals; Antimutagenic Agents; Carbachol; Cholinergic Agonists; Cobalt; Female; Medulla Oblongata; Microinjections; Neurons, Afferent; Nociceptors; Norepinephrine; Pain; Pons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tetracaine | 1999 |
Erythropoietin is produced by tubular cells of the rat kidney.
Topics: Adenosine Triphosphatases; Animals; Antimutagenic Agents; Blotting, Southern; Cobalt; Erythropoietin; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase | 1999 |
Developmental aspects and mechanisms of rat caudal hypothalamic neuronal responses to hypoxia.
Topics: Age Factors; Animals; Calcium; Cell Size; Cobalt; Fluorescent Dyes; Hypothalamus; Hypoxia; Hypoxia, Brain; Isoquinolines; Membrane Potentials; Neurons; Oxygen; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1999 |
Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation.
Topics: Base Sequence; Binding, Competitive; Cobalt; Cytochrome P-450 CYP1A1; Dioxins; DNA; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Promoter Regions, Genetic; Receptor Cross-Talk; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1999 |
Extracellular heavy-metal ions stimulate Ca2+ mobilization in hepatocytes.
Topics: Adenosine Triphosphate; Animals; Arginine Vasopressin; Cadmium Chloride; Calcium; Cell Line; Cells, Cultured; Chlorides; Cobalt; Copper; Ethylenediamines; Fluorescence; Fura-2; Hydrogen-Ion Concentration; Lanthanum; Liver; Magnesium; Male; Manganese Compounds; Metals, Heavy; Nickel; Rats; Rats, Wistar; Zinc Compounds | 1999 |
Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli.
Topics: Antimutagenic Agents; Cobalt; DNA Transposable Elements; Escherichia coli; Frameshift Mutation; Gene Deletion; Genes, Suppressor; Models, Genetic; Mutagenesis; Point Mutation; RNA, Transfer; Sequence Analysis, DNA | 1999 |
Improvement of brain SPECT by stabilization of Tc-99m-HMPAO with methylene blue or cobalt chloride. Comparison with Tc-99m-ECD.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebrovascular Disorders; Cobalt; Cysteine; Depression; Drug Stability; Female; Humans; Male; Methylene Blue; Middle Aged; Neurodegenerative Diseases; Organotechnetium Compounds; Radiopharmaceuticals; Scalp; Sensitivity and Specificity; Sleep Apnea Syndromes; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1999 |
Disposition, toxicity, and intestinal absorption of cobaltous chloride in male Fischer 344 rats.
Topics: Animals; Antimutagenic Agents; Biological Transport; Cobalt; Heme Oxygenase (Decyclizing); Intestinal Absorption; Intestine, Small; Male; Rats; Rats, Inbred F344; Tissue Distribution | 1999 |
Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Hypoxia; Cobalt; Cytochrome P-450 CYP1A1; Dimethyl Sulfoxide; Dioxins; DNA; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Phosphoglycerate Kinase; Polychlorinated Dibenzodioxins; Protein Binding; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1999 |
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.
Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine | 1999 |
Mechanism of stimulation of glucose transport in response to inhibition of oxidative phosphorylation: analysis with myc-tagged Glut1.
Topics: Animals; Azides; Biological Transport; Blotting, Western; Clone Cells; Cobalt; Fluorescent Antibody Technique; Genes, myc; Glucose; Glucose Transporter Type 1; Monosaccharide Transport Proteins; Oxidative Phosphorylation; Rats | 1999 |
L-dopaergic components in the caudal ventrolateral medulla in baroreflex neurotransmission.
Topics: alpha-Methyltyrosine; Animals; Aorta; Baroreflex; Blood Pressure; Catecholamines; Cobalt; Heart Rate; Levodopa; Male; Medulla Oblongata; Microinjections; Nervous System Physiological Phenomena; Phenylephrine; Pressoreceptors; Rats; Rats, Wistar; Solitary Nucleus; Synaptic Transmission | 1999 |
Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Reductase; Hemopexin; Liver; Male; Mercuric Chloride; Models, Biological; Oxidative Stress; Propranolol; Rats; Rats, Wistar; Time Factors | 1999 |
Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Bone Neoplasms; Breast Neoplasms; Bronchi; Cadmium Chloride; Carcinogens, Environmental; Cell Hypoxia; Cell Transformation, Neoplastic; Cobalt; Cricetinae; Cricetulus; DNA-Binding Proteins; Epithelial Cells; Fibroblasts; Gene Expression Regulation; Genes, p53; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mice; Neoplasm Proteins; Nickel; Nuclear Proteins; Osteosarcoma; Promoter Regions, Genetic; Recombinant Fusion Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
GABA(A) and GABA(C) receptors have contrasting effects on excitability in superior colliculus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cobalt; Electric Stimulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; In Vitro Techniques; Lidocaine; Muscimol; Rats; Rats, Long-Evans; Receptors, GABA; Receptors, GABA-A; Superior Colliculi | 1999 |
HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Iron Chelating Agents; Iron Deficiencies; Mice; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Receptors, Transferrin; Response Elements; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1999 |
Membrane recycling in the neuronal growth cone revealed by FM1-43 labeling.
Topics: Animals; Cell Membrane; Cells, Cultured; Chick Embryo; Cobalt; Endocytosis; Endosomes; Fluorescent Dyes; Ganglia, Parasympathetic; Kinetics; Neurons; Potassium Chloride; Pyridinium Compounds; Quaternary Ammonium Compounds; Synaptic Vesicles | 1999 |
Tissue variant effects of heme inhibitors on the mouse cytochrome c oxidase gene expression and catalytic activity of the enzyme complex.
Topics: Adenosine Triphosphate; Animals; Brain; Catalysis; Cobalt; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex IV; Enzyme Induction; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Heptanoates; Iron; Kidney; Mice; Mitochondria; Mitochondria, Liver; Multienzyme Complexes; Organ Specificity; Porphobilinogen Synthase; RNA, Messenger | 1999 |
Interaction of Schiff base with bovine serum albumin: site-specific photocleavage.
Topics: Animals; Binding Sites; Cattle; Circular Dichroism; Cobalt; In Vitro Techniques; Kinetics; Photochemistry; Protein Binding; Schiff Bases; Serum Albumin, Bovine; Spectrophotometry | 1999 |
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and ery
Topics: Activating Transcription Factor 1; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Chelating Agents; Cobalt; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deferoxamine; DNA-Binding Proteins; Enzyme Induction; Erythropoietin; Fetus; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Glutathione; Glycolysis; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate Dehydrogenase; Mimosine; Neurons; Neuroprotective Agents; Nuclear Proteins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transcription Factors | 1999 |
Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Cycloheximide; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Glycolysis; Lactic Acid; Male; Monosaccharide Transport Proteins; Oxidative Phosphorylation; Oxygen; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Azide; Up-Regulation | 1999 |
A novel staining method for detecting phytase activity.
Topics: 6-Phytase; Animals; Aspergillus; Cattle; Cobalt; Coloring Agents; Culture Media; Electrophoresis, Polyacrylamide Gel; Molybdenum; Phytic Acid; Selenomonas; Staining and Labeling; Streptococcus bovis; Vanadates | 1999 |
Hypoxia increases glyceraldehyde-3-phosphate dehydrogenase transcription in rat alveolar epithelial cells.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Enzyme Induction; Epithelial Cells; Glyceraldehyde-3-Phosphate Dehydrogenases; Oxygen; Precipitin Tests; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; RNA Stability; RNA, Messenger; Time Factors; Transcription, Genetic | 1999 |
Simple chemicals can induce maturation and apoptosis of dendritic cells.
Topics: Antigens, CD; Antimutagenic Agents; Apoptosis; B7-2 Antigen; Biomarkers; Cell Differentiation; Cells, Cultured; Chlorides; Cobalt; Copper; Dendritic Cells; Dermatitis, Contact; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression; Genes, fms; Haptens; HLA-DR Antigens; Humans; Macrophages; Magnesium Chloride; Membrane Glycoproteins; Metals; Nickel; Picryl Chloride; Statistics, Nonparametric; T-Lymphocytes; Tumor Necrosis Factor-alpha; Zinc Compounds | 1999 |
Nickel and cobalt reagents promote selective oxidation of Z-DNA.
Topics: Chromium Alloys; Cobalt; Deoxyribonucleotides; DNA; Indicators and Reagents; Nickel; Nucleic Acid Heteroduplexes; Organometallic Compounds; Oxidation-Reduction; Plasmids | 1999 |
Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS.
Topics: Acetylcholine; Animals; Arginine; Arterioles; Carbon Monoxide; Cobalt; Enzyme Induction; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; In Vitro Techniques; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Renal Artery; Vasodilation | 1999 |
In vitro cytotoxicity of various forms of cobalt for rat alveolar macrophages and type II pneumocytes.
Topics: Animals; Cell Survival; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Drug Interactions; Edetic Acid; Lactalbumin; Lung; Macrophages, Alveolar; Male; Microscopy, Electron; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles; Time Factors; Tungsten Compounds | 2000 |
False-positive "poral" cobalt patch test reactions reside in the eccrine acrosyringium.
Topics: Cobalt; Dermatitis, Allergic Contact; Diagnosis, Differential; Eccrine Glands; False Positive Reactions; Humans; Irritants; Nickel; Patch Tests | 2000 |
Oxygen induction of epithelial Na(+) transport requires heme proteins.
Topics: Amiloride; Animals; Biological Transport; Carrier Proteins; Cobalt; Epithelial Cells; Epithelial Sodium Channels; Fetus; Heme; Hemeproteins; Iron; Iron Chelating Agents; Iron-Binding Proteins; Lung; Metals; Oxygen; Rats; Rats, Wistar; RNA, Messenger; Sodium; Sodium Channels; Transferrin-Binding Proteins | 2000 |
Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o).
Topics: 2-Chloroadenosine; Animals; Baclofen; Barium Compounds; Calcium; Calcium Channels; Chlorides; Cobalt; Enzyme Inhibitors; Ethylmaleimide; Female; GABA Agonists; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Hippocampus; Kinetics; Male; Membrane Potentials; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Potassium; Potassium Channels; Receptors, GABA-B; Receptors, Purinergic P1 | 2000 |
Glutamate-induced cobalt uptake reveals non-NMDA receptors in rat taste cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cobalt; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Staining and Labeling; Taste Buds | 2000 |
Cross-reactivity patterns of cobalt and nickel studied with repeated open applications (ROATS) to the skin of guinea pigs.
Topics: Animals; Cobalt; Cross Reactions; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Guinea Pigs; Irritants; Nickel; Patch Tests; Sensitivity and Specificity | 2000 |
[Effect of the isoosmotic solution with decreased sodium level on mitochondria of cultured granule cells from the cerebellum].
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Membrane Potentials; Mitochondria; Neurons; Osmosis; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Solutions; Sucrose | 2000 |
Nic1p, a relative of bacterial transition metal permeases in Schizosaccharomyces pombe, provides nickel ion for urease biosynthesis.
Topics: Amino Acid Sequence; Biological Transport, Active; Carrier Proteins; Cation Transport Proteins; Cobalt; Membrane Proteins; Molecular Sequence Data; Mutation; Nickel; Open Reading Frames; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Alignment; Urease | 2000 |
Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity.
Topics: Adenoviridae; Animals; Cobalt; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gene Transfer Techniques; Genetic Vectors; Heme; Heme Oxygenase (Decyclizing); Humans; Kidney; Liver; Male; Oxygenases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transduction, Genetic | 2000 |
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Topics: Animals; Antimutagenic Agents; Cell Hypoxia; Cobalt; DNA Damage; DNA Glycosylases; DNA, Mitochondrial; Escherichia coli; Humans; Kinetics; N-Glycosyl Hydrolases; Neurites; Neurons; PC12 Cells; Polymerase Chain Reaction; Rats | 2000 |
Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-stimulated Cyp1a1 promoter activity by hypoxic agents.
Topics: Animals; Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Chelating Agents; Cobalt; Cytochrome P-450 CYP1A1; Deferoxamine; Dose-Response Relationship, Drug; Drug Interactions; Ferrous Compounds; Gene Expression Regulation, Enzymologic; Genes, Reporter; Luciferases; Mice; Oxygen; Picolinic Acids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Time Factors | 2000 |
Electrophysiological properties of ventricular muscle obtained from spontaneously diabetic mice.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Blood Glucose; Calcium Channel Blockers; Calcium Channels, L-Type; Cobalt; Diabetes Mellitus, Type 2; Electric Conductivity; Electrophysiology; Heart Ventricles; Insulin; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Obesity; Pancreas; Potassium Channels | 2000 |
Prevalence of delayed hypersensitivity to the European standard series in a self-selected population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Caustics; Cobalt; Dermatitis, Allergic Contact; Environmental Exposure; Female; Humans; Irritants; Male; Middle Aged; Nickel; Patch Tests; Patient Selection; Perfume; Potassium Dichromate; Prevalence; Western Australia | 2000 |
Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells.
Topics: Cell Hypoxia; Cells, Cultured; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Muscle, Smooth, Vascular; Nuclear Proteins; Oxygen; RNA, Messenger; Transcription Factors | 2000 |
Nitric oxide inhibits dioxin action for the stimulation of Cyp1a1 promoter activity.
Topics: Animals; Arginine; Cells, Cultured; Cobalt; Cytochrome P-450 CYP1A1; Deferoxamine; Dioxins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Lipopolysaccharides; Luciferases; Mice; Nitric Oxide; Nitroarginine; Nitroprusside; Picolinic Acids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Teratogens; Transfection | 2000 |
Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Cobalt; Egtazic Acid; Estrenes; Female; Luteinizing Hormone; Periodicity; Pertussis Toxin; Phosphodiesterase Inhibitors; Pyrrolidinones; Second Messenger Systems; Signal Transduction; Swine; Theca Cells; Type C Phospholipases; Virulence Factors, Bordetella | 2000 |
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Topics: Androstadienes; Animals; Cell Line; Cell Nucleus; Chelating Agents; Cobalt; Cytosol; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex III; Electron Transport Complex IV; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Marine Toxins; Mitochondria; Mitochondria, Liver; Models, Biological; Nuclear Proteins; Oxazoles; Oxidation-Reduction; Oxygen; Paracoccus denitrificans; Rats; Reactive Oxygen Species; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
The contribution of the median preoptic nucleus to renal sympathetic nerve activity increased by intracerebroventricular injection of hypertonic saline in the rat.
Topics: Anesthetics, Local; Animals; Antimutagenic Agents; Cobalt; Electric Stimulation; Electrophysiology; Hypertonic Solutions; Injections, Intraventricular; Kidney; Lidocaine; Male; Paraventricular Hypothalamic Nucleus; Preoptic Area; Rats; Rats, Wistar; Sodium Chloride; Stimulation, Chemical; Sympathetic Nervous System; Water-Electrolyte Balance | 2000 |
A projection from the ventral tegmental area to the periaqueductal gray involved in cardiovascular regulation.
Topics: Anesthetics, Local; Animals; Antimutagenic Agents; Biotin; Blood Pressure; Brain Stem; Cardiovascular System; Cobalt; Dextrans; Glutamic Acid; Lidocaine; Male; Medial Forebrain Bundle; Microinjections; Nerve Block; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2000 |
New methods of dye application for staining motor neurons in an insect.
Topics: Animals; Axonal Transport; Axotomy; Cobalt; Coloring Agents; Microinjections; Motor Neurons; Muscles; Neurosciences; Nickel; Periplaneta; Staining and Labeling | 2000 |
Caudal midline medulla mediates behaviourally-coupled but not baroreceptor-mediated vasodepression.
Topics: Animals; Antimutagenic Agents; Blood Pressure; Bradycardia; Cobalt; Free Radical Scavengers; Heart Rate; Hemorrhage; Hypotension; Male; Medulla Oblongata; Models, Biological; Pressoreceptors; Rats; Rats, Sprague-Dawley; Serotonin; Signal Transduction | 2000 |
Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism.
Topics: Carcinogens; Cell Cycle Proteins; Cell Hypoxia; Cobalt; DNA-Binding Proteins; Endothelium, Vascular; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mercaptoethanol; Nickel; Nuclear Proteins; Proteins; Reactive Oxygen Species; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line.
Topics: Androgens; Cell Hypoxia; Cobalt; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Endothelial Growth Factors; Enzyme Induction; Humans; Isoenzymes; Lymphokines; Male; Membrane Proteins; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Stimulation, Chemical; Sulfonamides; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells.
Topics: Animals; Arsenites; Base Sequence; beta-Galactosidase; Binding Sites; Cells, Cultured; Chick Embryo; Chickens; Chloramphenicol O-Acetyltransferase; Cobalt; Consensus Sequence; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Liver; Mammals; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Sodium Compounds; Transfection | 2000 |
Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures.
Topics: Animals; Arteries; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Blotting, Northern; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; Fluorescent Dyes; Heme; Hepatocytes; Immunoblotting; Male; Nucleic Acid Synthesis Inhibitors; Oxygen; Rats; Rats, Wistar; Rhodamine 123; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Veins | 2000 |
Redox regulation of p53 during hypoxia.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcysteine; Animals; Antioxidants; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Death; Cell Division; Cell Hypoxia; Cells, Cultured; Chick Embryo; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Ditiocarb; Fibroblasts; Fluoresceins; Humans; Hydrogen Peroxide; Mice; Mitochondria; Myocardium; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uncoupling Agents | 2000 |
Pharmacological characterization of the effects of methylmercury and mercuric chloride on spontaneous noradrenaline release from rat hippocampal slices.
Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Caffeine; Calcium; Calcium Channel Blockers; Chelating Agents; Chromatography, High Pressure Liquid; Cobalt; Desipramine; Egtazic Acid; Enzyme Inhibitors; Hippocampus; Male; Mercuric Chloride; Methylmercury Compounds; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Reserpine; Ruthenium Red; Sodium Channel Blockers; Sodium-Calcium Exchanger; Synapses; Tetrodotoxin; Thapsigargin | 2000 |
Sensitizing potential of cobalt chloride in the open epicutaneous test (OET).
Topics: Animals; Cobalt; Dermatitis, Contact; Guinea Pigs; Patch Tests; Skin Tests | 2000 |
Synthesis and characterization of a cobalt(III) complex with 1-(D-3-mercapto-2-methylpropionyl)-L-proline.
Topics: Captopril; Cobalt; Models, Molecular; Oxidation-Reduction; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2000 |
Induction of adrenomedullin during hypoxia in cultured human glioblastoma cells.
Topics: Actins; Adrenomedullin; Blotting, Northern; Brain Neoplasms; Cell Hypoxia; Cobalt; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Gene Expression Regulation; Glioblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Peptides; Protein Synthesis Inhibitors; Radioimmunoassay; RNA Stability; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2000 |
Release of prostaglandin E2, IL-6 and IL-8 from human oral epithelial culture models after exposure to compounds of dental materials.
Topics: Biocompatible Materials; Carcinoma, Squamous Cell; Cell Survival; Cobalt; Culture Techniques; Dental Materials; Dinoprostone; Epithelial Cells; Humans; Interleukin-6; Interleukin-8; Interleukins; Materials Testing; Mitochondria; Models, Biological; Mouth Mucosa; Nickel; Palladium; Polyethylene Glycols; Polymethacrylic Acids; Statistics, Nonparametric; Tumor Cells, Cultured | 2000 |
Impairment of cardiac energy metabolism in vivo causes hemodynamic abnormality and increases cardiac expression of preproendothelin-1 mRNA.
Topics: Animals; Atrial Natriuretic Factor; Cobalt; Endothelin-1; Endothelins; Energy Metabolism; Heart Failure; Male; Myocardium; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co(2+).
Topics: Adaptation, Physiological; Animals; Antimutagenic Agents; Cobalt; Coronary Circulation; Dose-Response Relationship, Drug; Energy Metabolism; Glycogen; Heart; Hematocrit; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Organ Size; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Ventricular Pressure | 2000 |
Crystal structures of a Rab protein in its inactive and active conformations.
Topics: Binding Sites; Catalysis; Cobalt; Crystallography, X-Ray; Fungal Proteins; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Magnesium; Models, Molecular; Protein Structure, Secondary; rab GTP-Binding Proteins; Saccharomyces cerevisiae Proteins | 2000 |
Micturition evoked by glutamate microinjection in the ventrolateral periaqueductal gray is mediated through Barrington's nucleus in the rat.
Topics: Animals; Cobalt; Glutamic Acid; Male; Microinjections; Muscle Contraction; Muscle, Smooth; Periaqueductal Gray; Pons; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali; Urinary Bladder; Urination | 2000 |
Hypoxia promotes fibrogenesis in human renal fibroblasts.
Topics: Actins; Antimutagenic Agents; Cell Division; Cell Hypoxia; Cell Size; Cell Survival; Cells, Cultured; Chelating Agents; Cobalt; Collagen; Collagenases; Culture Media, Conditioned; Deferoxamine; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypoxia; Kidney Cortex; Kidney Failure, Chronic; Oxygen; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2000 |
DNA condensation in two dimensions.
Topics: Bacteriophage lambda; Cations, Divalent; Chlorides; Cobalt; DNA; DNA, Viral; Fatty Acids, Monounsaturated; Lipid Bilayers; Magnesium Chloride; Manganese Compounds; Models, Molecular; Nucleic Acid Conformation; Phosphatidylcholines; Quaternary Ammonium Compounds; Spermidine; Spermine | 2000 |
Intracortical pathway involving dysgranular cortex conveys hindlimb inputs to S-I forelimb-stump representation of neonatally amputated rats.
Topics: Afferent Pathways; Amputation Stumps; Animals; Animals, Newborn; Brachial Plexus; Brain Mapping; Cobalt; Electric Stimulation; Electrodes, Implanted; Forelimb; Hindlimb; Microinjections; Rats; Sciatic Nerve; Somatosensory Cortex | 2001 |
Accumulation of HIF-1alpha under the influence of nitric oxide.
Topics: Animals; Benzoates; Cell Hypoxia; Cell Line; Cobalt; Coculture Techniques; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Guanylate Cyclase; Hydrazines; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Inflammation; Kidney Tubules, Proximal; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Nitroso Compounds; Nuclear Proteins; Oxadiazoles; Oxazines; S-Nitrosoglutathione; Spermine; Swine; Transcription Factors | 2001 |
Sensitivity of FRDA lymphoblasts to salts of transition metal ions.
Topics: Blotting, Western; Cell Survival; Cells, Cultured; Chlorides; Cobalt; Copper Sulfate; Dose-Response Relationship, Drug; Ferric Compounds; Fibroblasts; Friedreich Ataxia; Humans; Hydrogen Peroxide; Ions; Magnesium Chloride; Manganese Compounds; Reactive Oxygen Species; Salts; Zinc Compounds | 2000 |
Inhibitors of ethylene synthesis inhibit auxin-induced stomatal opening in epidermis detached from leaves of Vicia faba L.
Topics: Amino Acid Oxidoreductases; Amino Acids, Cyclic; Aminoisobutyric Acids; Cobalt; Ethylenes; Glycine; Indoleacetic Acids; Lyases; Plant Leaves; Rosales; Thiosulfates | 2001 |
Regulation of heme oxygenase activity in rat liver during oxidative stress induced by cobalt chloride and mercury chloride.
Topics: Animals; Cobalt; Heme Oxygenase (Decyclizing); Liver; Mercuric Chloride; Oxidative Stress; Rats; Rats, Wistar; Vitamin E | 2001 |
Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Calcium; Cobalt; Colforsin; Cyclic AMP; Glucagon; Glucose; In Vitro Techniques; Isoenzymes; Liver; Male; Perfusion; Rats; Rats, Wistar; Secretin; Vasoactive Intestinal Peptide | 2001 |
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Antimutagenic Agents; Apoptosis; Blotting, Northern; Cell Line; Cell Nucleus; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; DNA-Binding Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Inhibitor of Apoptosis Proteins; Kidney; Mice; Models, Biological; Nuclear Proteins; Oxidation-Reduction; Oxygen; Protein Synthesis Inhibitors; Proteins; Rats; Stem Cells; Transcription Factors; Transcription, Genetic; Up-Regulation | 2001 |
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Topics: Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Humans; Hydroxylation; Hydroxyproline; Ligases; Mass Spectrometry; Mice; Molecular Sequence Data; Oxygen; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitins; Von Hippel-Lindau Tumor Suppressor Protein | 2001 |
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus.
Topics: B-Lymphocytes; Blotting, Western; Capsid; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Glycoproteins; Herpesvirus 8, Human; Humans; Interleukin-6; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Viral Proteins; Virus Replication | 2001 |
Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Cells, Cultured; Cobalt; Cricetinae; DNA-Binding Proteins; DNA, Antisense; Endothelin-1; Energy Metabolism; Gene Expression Regulation; Hemodynamics; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Mitochondria; Myocardial Infarction; Myocardium; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Transcription Factors | 2001 |
Activities of apoptotic signal 1-regulating protein kinase and poly-(ADP-ribose) polymerase and internucleosomal DNA fragmentation in rat liver during oxidative stress induced by cobalt chloride.
Topics: Animals; Cobalt; DNA Fragmentation; Female; Liver; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar | 2001 |
Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells.
Topics: Blood Proteins; Carcinogens; Carrier Proteins; Cell Hypoxia; Cobalt; Dimerization; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophilins; Male; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Protein Subunits; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Up-Regulation | 2001 |
Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation.
Topics: Animals; Antimutagenic Agents; Antioxidants; Apoptosis; bcl-X Protein; Cobalt; Neurons; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Transcription Factor AP-1 | 2001 |
Mixtures of nickel and cobalt chlorides induce synergistic cytotoxic effects: implications for inhalation exposure modeling.
Topics: Air Pollutants; Animals; Cell Survival; Cells; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Humans; Models, Theoretical; Nickel; Occupational Exposure; Pulmonary Alveoli | 2001 |
Hard metal-induced disease: effects of metal cations in vitro on guinea pig isolated airways.
Topics: Alloys; Animals; Bronchoconstrictor Agents; Cadmium Chloride; Cations; Chlorides; Chromium Compounds; Cobalt; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nickel; Solubility; Tantalum; Trachea; Tungsten; Zinc Compounds | 2001 |
Evidence that hemorrhagic hypotension is mediated by the ventrolateral periaqueductal gray region.
Topics: Animals; Blood Pressure; Cobalt; Heart Rate; Hemorrhage; Hypotension; Lidocaine; Male; Microinjections; Periaqueductal Gray; Rats; Synaptic Transmission; Wakefulness | 2001 |
Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain; Cobalt; DNA-Binding Proteins; Erythropoietin; Female; Fructose-Bisphosphate Aldolase; Gene Expression; Glucose Transporter Type 1; Glycolysis; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Ischemic Preconditioning; L-Lactate Dehydrogenase; Male; Monosaccharide Transport Proteins; Nuclear Proteins; Phosphofructokinase-1; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors | 2001 |
Regulation of the gravitropic response and ethylene biosynthesis in gravistimulated snapdragon spikes by calcium chelators and ethylene inhibitors.
Topics: Amino Acids; Amino Acids, Cyclic; beta-Fructofuranosidase; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Chelating Agents; Cobalt; Cyclopropanes; Ethylenes; Glycoside Hydrolases; Gravitropism; Indoleacetic Acids; Lanthanum; Norbornanes; Plant Development; Plant Stems; Plants; Second Messenger Systems; Signal Transduction | 1996 |
Evaluation of ethylene as a mediator of gravitropism by tomato hypocotyls.
Topics: Amino Acids; Amino Acids, Cyclic; Cobalt; Ethylenes; Glycine; Gravitation; Gravitropism; Hypocotyl; Rotation; Solanum lycopersicum; Time Factors | 1986 |
Further studies of auxin and ACC induced feminization in the cucumber plant using ethylene inhibitors.
Topics: Amino Acids; Amino Acids, Cyclic; Antimutagenic Agents; Cobalt; Cucumis sativus; Ethylenes; Glycine; Indoleacetic Acids; Organophosphorus Compounds; Plant Growth Regulators; Silver Nitrate | 1984 |
Chemical suppression of gravitropic bending response in flower stalks of snapdragon (Antirrhinum majus L.).
Topics: Chelating Agents; Cobalt; Dose-Response Relationship, Drug; Edetic Acid; Ethylenes; Gravitropism; Magnoliopsida; Plant Growth Regulators; Plant Stems; Polyethylene Glycols; Signal Transduction; Surface-Active Agents; Vanadates | 1997 |
Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart.
Topics: Animals; Carboxy-Lyases; Carnitine O-Palmitoyltransferase; Cobalt; Down-Regulation; Energy Metabolism; Gene Expression; Heart; Hemodilution; Hypoxia; Isoenzymes; Male; Myocardium; Oxygen; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2001 |
Transcriptional regulation of heme oxygenases by HIF-1alpha in renal medullary interstitial cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Hypoxia; Cobalt; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Kidney Medulla; Leupeptins; Male; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transfection | 2001 |
Crystal and molecular structure of a new cobalt complex of quinine.
Topics: Cobalt; Crystallography, X-Ray; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Organometallic Compounds; Quinine | 2001 |
Transcriptional repression of the human p53 gene by cobalt chloride mimicking hypoxia.
Topics: Cell Hypoxia; Cobalt; Dose-Response Relationship, Drug; E-Box Elements; Genes, myc; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Promoter Regions, Genetic; Sequence Deletion; Transcription Factors; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53 | 2001 |
Stability evaluation of a cement based waste form to microbially induced degradation.
Topics: Acidithiobacillus thiooxidans; Biodegradation, Environmental; Biological Availability; Calcium; Cobalt; Environmental Monitoring; Hydrogen-Ion Concentration; Industrial Waste; Manufactured Materials; Refuse Disposal; Reproducibility of Results | 2001 |
Luminol chemiluminescence in unbuffered solutions with a cobalt(II)-ethanolamine complex immobilized on resin as catalyst and its application to analysis.
Topics: Anion Exchange Resins; Buffers; Catalysis; Cations; Cobalt; Cross-Linking Reagents; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Ethanolamine; Glucose; Glycosuria; Humans; Hydrogen Peroxide; Indicators and Reagents; Luminescent Measurements; Metals; Nitroblue Tetrazolium; Nitrogen; Oxygen; Reactive Oxygen Species; Resins, Synthetic; Solutions | 2001 |
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane.
Topics: Anaerobiosis; Anesthetics, Inhalation; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Halothane; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcinogens; Cell Cycle Proteins; Cobalt; Diethylnitrosamine; DNA Damage; DNA-Binding Proteins; Fatty Acids, Unsaturated; Female; Hepatocytes; Liver Neoplasms; Precancerous Conditions; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2001 |
Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells.
Topics: Adrenomedullin; Antimutagenic Agents; Cell Hypoxia; Cobalt; Deferoxamine; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Iron Chelating Agents; Membrane Proteins; Neuroblastoma; Peptides; Receptor Activity-Modifying Protein 2; Receptor Activity-Modifying Proteins; Receptors, Adrenomedullin; Receptors, Peptide; Tumor Cells, Cultured | 2001 |
Heme oxygenase is the main protective enzyme in rat liver upon 6-day administration of cobalt chloride.
Topics: Animals; Cobalt; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Lipid Peroxidation; Male; Microsomes, Liver; Oxidative Stress; Rats; Rats, Wistar; Time Factors | 2001 |
White adipocyte vascular endothelial growth factor: regulation by insulin.
Topics: Adipocytes; Animals; Cobalt; Culture Techniques; Endothelial Growth Factors; Hypoglycemic Agents; Insulin; Lymphokines; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Hypoxia links ATR and p53 through replication arrest.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Division; Cell Hypoxia; Cell Line; Cell Nucleus; Cobalt; Comet Assay; DNA Damage; DNA Replication; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Serine-Threonine Kinases; S Phase; Signal Transduction; Stress, Physiological; Transcription Factors; Tumor Suppressor Protein p53 | 2002 |
Activation of the hexose monophosphate shunt in rat type II pneumocytes as an early marker of oxidative stress caused by cobalt particles.
Topics: Animals; Biomarkers; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Drug Combinations; Dust; Hydrogen Peroxide; Male; Oxidative Stress; Particle Size; Pentose Phosphate Pathway; Pulmonary Alveoli; Rats; Rats, Wistar; tert-Butylhydroperoxide; Tungsten Compounds | 2002 |
Haem metabolic aspects on nitric oxide formation in endotoxaemia.
Topics: Animals; Cell Line; Ceruloplasmin; Cobalt; Cytochrome P-450 Enzyme System; Deferoxamine; Endotoxemia; Endotoxins; Heme Oxygenase (Decyclizing); Iron; Lipopolysaccharides; Liver; Male; Mice; Microsomes; Nitric Oxide; Rats; Rats, Wistar | 2001 |
Glucose uptake and lactate production in cells exposed to CoCl(2) and in cells overexpressing the Glut-1 glucose transporter.
Topics: 3T3 Cells; Animals; Antimutagenic Agents; Cells, Cultured; Cobalt; Glucose; Glucose Transporter Type 1; Lactic Acid; Mice; Monosaccharide Transport Proteins | 2002 |
Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures.
Topics: Animals; Antimutagenic Agents; Arachidonic Acid; Calcium; Calcium Channels; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Cobalt; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Intracellular Fluid; Neurons; Neurotransmitter Uptake Inhibitors; Phospholipases A; Phospholipases A2; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2002 |
Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells.
Topics: Animals; Antimutagenic Agents; Apoptosis; Caspase 3; Caspases; Cobalt; Cysteine Proteinase Inhibitors; Flow Cytometry; Inhibitor of Apoptosis Proteins; Mitogen-Activated Protein Kinases; Neurons; Oligopeptides; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Rats; Viral Proteins | 2002 |
The effects of crustacean cardioactive peptide on locust oviducts are calcium-dependent.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Chelating Agents; Cobalt; Egtazic Acid; Female; Grasshoppers; Muscle Contraction; Neuropeptides; Oviducts | 2002 |
Suitability of the European standard series of patch test allergens in Pakistani patients.
Topics: Adult; Allergens; Cobalt; Dermatitis, Contact; Dermatitis, Occupational; Europe; Female; Humans; Male; Middle Aged; Nickel; Pakistan; Patch Tests; Potassium Dichromate; Sensitivity and Specificity | 2002 |
Thermo-mechanical analysis of a compliant poly(carbonate-urea)urethane after exposure to hydrolytic, oxidative, peroxidative and biological solutions.
Topics: Blood Vessel Prosthesis; Cobalt; Hydrogen Peroxide; Hydrolysis; Ions; Materials Testing; Oxygen; Peroxides; Phospholipases A; Phospholipases A2; Polymers; Polytetrafluoroethylene; Polyurethanes; Sterol Esterase; Temperature | 2002 |
Mechanisms of oxygen sensing in human trophoblast cells.
Topics: Adult; Chorionic Villi; Cobalt; Deferoxamine; Drug Combinations; Enzyme Inhibitors; Female; Ferrous Compounds; Hemeproteins; Humans; Hypoxia; Iron Chelating Agents; Mitochondria; Onium Compounds; Organ Culture Techniques; Oxygen; Oxygen Consumption; Pregnancy; Pregnancy Trimester, First; Rotenone; Trophoblasts; Uncoupling Agents | 2002 |
Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Cobalt; Cyclic AMP Response Element-Binding Protein; Deferoxamine; DNA, Complementary; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hypoxia; Inhibitor of Apoptosis Proteins; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger; Sequence Deletion; Sequence Homology, Amino Acid; Sp1 Transcription Factor; Viral Proteins | 2002 |
Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA Primers; Gene Expression Regulation; Humans; Liver; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 1; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor Tyrosine Kinase-like Orphan Receptors; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation | 2002 |
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.
Topics: Animals; Cell Line; Cell Nucleus; Cobalt; DNA-Binding Proteins; Endothelial Growth Factors; Gene Expression Regulation; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Kinetics; Lymphokines; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pigment Epithelium of Eye; Plasmids; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Transcription Factors; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbon Monoxide; Cobalt; DNA-Binding Proteins; Gene Expression; Glucose Transporter Type 1; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Kidney; Male; Monosaccharide Transport Proteins; Nuclear Proteins; Oxygen; Phlebotomy; Protein Isoforms; Rats; Rats, Sprague-Dawley; Renal Circulation; Staining and Labeling; Trans-Activators; Transcription Factors | 2002 |
Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on integrity of subnucleus caudalis.
Topics: Animals; Brain; Cobalt; Injections; Male; Mustard Plant; Neuronal Plasticity; Nociceptors; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Sodium Chloride; Trigeminal Nucleus, Spinal | 2002 |
HIF-1alpha-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway.
Topics: Blotting, Western; Cell Line; Cobalt; DNA Fragmentation; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ketoglutaric Acids; Luciferases; Nitric Oxide; Oxygen; Procollagen-Proline Dioxygenase; Protein Binding; Protein Structure, Tertiary; Sepharose; Signal Transduction; Sodium Chloride; Time Factors; Transcription Factors; Transcription, Genetic; Transfection | 2002 |
Mitochondrial permeability transition can be directly monitored in living neurons.
Topics: Animals; Calcium; Cells, Cultured; Cobalt; Embryo, Mammalian; Fluoresceins; Ion Channels; Microscopy, Fluorescence; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neocortex; Neurons; Organometallic Compounds; Permeability; Rats; Rats, Sprague-Dawley | 2002 |
Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Blotting, Western; Cell Hypoxia; Cell Line; Cell Movement; Cobalt; Cycloheximide; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mutation; Nuclear Proteins; Plasmids; Proteins; Proto-Oncogene Proteins c-raf; Pyrazoles; Pyrimidines; ras Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases; Transcription Factors; Transfection; Tyrphostins; Ubiquitin | 2002 |
Changes in the motility of B16F10 melanoma cells induced by alterations in resting calcium influx.
Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Adhesion; Cell Movement; Chlorides; Cobalt; Extracellular Space; Fibroblast Growth Factor 2; Gadolinium; Humans; Ion Transport; Ionomycin; Manganese Compounds; Melanoma; Potassium; Terbium; Tumor Cells, Cultured | 2002 |
Allergy to pectus bar for funnel chest.
Topics: Adolescent; Cobalt; Dermatitis, Contact; Device Removal; Diagnosis, Differential; Eosinophilia; Funnel Chest; Humans; Male; Palladium; Pleural Effusion; Postoperative Complications; Prostheses and Implants; Radiography; Reoperation | 2002 |
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
Topics: Amino Acids, Dicarboxylic; Animals; Chelating Agents; Cobalt; Deferoxamine; Fibroblasts; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron; Luciferases; Mice; Mice, Knockout; Proline; Protein Binding; Transcription Factors; Transfection | 2002 |
Occupational dermatoses among fibreglass-reinforced plastics factory workers.
Topics: Adult; Allergens; Benzoyl Peroxide; Catechols; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Glass; Humans; Industry; Japan; Male; Middle Aged; Patch Tests; Resins, Synthetic; Surveys and Questionnaires | 2002 |
Inhibition of proteasome activity is involved in cobalt-induced apoptosis of human alveolar macrophages.
Topics: Antimutagenic Agents; Apoptosis; Cobalt; Cysteine Endopeptidases; Humans; Macrophages, Alveolar; Mitochondria; Multienzyme Complexes; Proteasome Endopeptidase Complex; Reactive Oxygen Species; U937 Cells; Ubiquitin | 2002 |
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
Topics: Cell Hypoxia; Chromones; Cobalt; DNA-Binding Proteins; Enzyme Inhibitors; Glucose Transporter Type 1; Helix-Loop-Helix Motifs; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Monosaccharide Transport Proteins; Morpholines; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2002 |
Genotoxicity is modulated by ascorbic acid. Studies using the wing spot test in Drosophila.
Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Genetically Modified; Antimutagenic Agents; Ascorbic Acid; Carcinogens; Cobalt; Coloring Agents; Drosophila melanogaster; Eye Color; Female; Genes, Insect; Larva; Male; Mutagenicity Tests; Mutation; Potassium Dichromate; Wings, Animal | 2002 |
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Hypoxia; Cobalt; Cysteine Endopeptidases; Endothelial Growth Factors; Estradiol; Estrogen Receptor alpha; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Signaling Peptides and Proteins; Leupeptins; Lymphokines; Multienzyme Complexes; Promoter Regions, Genetic; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteins; Receptors, Estrogen; Response Elements; Sp1 Transcription Factor; Transcription Factors; Transcriptional Activation; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cell Line; Cell Nucleus; Chondrocytes; Cobalt; Collagen; Cyclic AMP; DNA-Binding Proteins; HeLa Cells; Homeodomain Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Molecular Sequence Data; Oxidation-Reduction; Plasmids; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Transcription, Genetic; Transfection | 2002 |
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.
Topics: 3T3 Cells; Animals; Cobalt; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Fibroblasts; Gene Deletion; Genes, Dominant; HeLa Cells; Homozygote; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Kinetics; Methionine; Mice; Models, Biological; Oxygen; Phosphorylation; Plasmids; Protein Biosynthesis; Protein Folding; Proteins; Serine; Thapsigargin; Time Factors; Transcription Factors; Transfection | 2002 |
Antinociception from lateral hypothalamic stimulation may be mediated by NK(1) receptors in the A7 catecholamine cell group in rat.
Topics: Animals; Antimutagenic Agents; Carbachol; Catecholamines; Cholinergic Agonists; Cobalt; Female; Hypothalamic Area, Lateral; Microinjections; Neural Pathways; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Threshold; Pons; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1 | 2002 |
Agonist-stimulated cobalt uptake provides selective visualization of neurons expressing AMPA- or kainate-type glutamate receptors in the retina.
Topics: Animals; Cats; Cobalt; Excitatory Amino Acid Agonists; Neurons; Receptors, AMPA; Receptors, Kainic Acid; Retina | 2002 |
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Hypoxia; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Tumor Cells, Cultured | 2002 |
Effect of hypoxia on placental activin A, inhibin A and follistatin synthesis.
Topics: Activins; Adult; Cell Hypoxia; Cells, Cultured; Cobalt; Endothelial Growth Factors; Endothelium, Vascular; Female; Follistatin; Humans; Inhibin-beta Subunits; Inhibins; Intercellular Signaling Peptides and Proteins; Labor, Obstetric; Lymphokines; Organ Culture Techniques; Oxygen; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Alterations of the oxygen-evolving apparatus induced by a 305Arg --> 305Ser mutation in the CP43 protein of photosystem II from Synechocystis sp. PCC 6803 under chloride-limiting conditions.
Topics: Arginine; Calcium Chloride; Calcium Compounds; Chlorides; Cobalt; Culture Media, Conditioned; Cyanobacteria; Manganese Compounds; Mutagenesis, Site-Directed; Nitrates; Oxidoreductases; Photolysis; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Polarography; Serine; Spectrometry, Fluorescence; Sulfates | 2002 |
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Insecticides; Male; Methylcholanthrene; Motor Activity; Nervous System Diseases; Neurotoxins; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Tremor | 2003 |
[CoCl2-induced enhancement of glucose transport activity in mediating hypoxic tolerance in cultured hippocampal neurons].
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Glucose Transporter Type 1; Glucose Transporter Type 3; Hippocampus; Hypoxia; Neurons; Organometallic Compounds; Rats; Rats, Wistar; RNA, Messenger | 2002 |
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Blotting, Western; Cattle; Cell Line; Cobalt; Dactinomycin; Deferoxamine; Dimerization; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia; Interferon-gamma; Leucine Zippers; Luciferases; Membrane Proteins; Models, Genetic; Oxidative Stress; Oxygen; Promoter Regions, Genetic; Rats; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
Microvascular remodelling after endurance training with Co2+ treatment in the rat diaphragm and hind-leg muscles.
Topics: Animals; Cobalt; Diaphragm; Female; Hindlimb; Microcirculation; Muscle, Skeletal; Neovascularization, Physiologic; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Wistar | 2002 |
Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma-bearing mice: protective role of heme oxygenase.
Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Lewis Lung; Catalase; Cisplatin; Cobalt; Glutathione; Heme Oxygenase (Decyclizing); Lipid Peroxides; Liver; Male; Mice; Oxidative Stress; Random Allocation; Superoxide Dismutase | 2003 |
Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner.
Topics: Adrenergic Agents; Animals; Annexin A5; Apoptosis; Bilirubin; Cell Separation; Cobalt; Dose-Response Relationship, Drug; Flow Cytometry; Green Fluorescent Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Immunoblotting; Luminescent Proteins; Membrane Proteins; Microscopy, Confocal; Nerve Growth Factor; Oligonucleotides, Antisense; Oxidative Stress; Oxidopamine; PC12 Cells; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection; Up-Regulation | 2003 |
Effect of cobalt on the oxidative status in heart and aorta of streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Aorta; Catalase; Cobalt; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Male; Myocardium; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2003 |
Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Hypoxia; Cell Nucleus; Cell Separation; Cobalt; DNA, Complementary; Free Radical Scavengers; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Leupeptins; Male; NADPH Oxidases; Oligodeoxyribonucleotides, Antisense; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species; Transcription Factors; Transcriptional Activation; Vitamin K 3; Xanthine Oxidase | 2003 |
Contribution of quinolinic acid in the development of anemia in renal insufficiency.
Topics: Anemia; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Survival; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Erythropoiesis; Erythropoietin; Humans; Kidney Failure, Chronic; Male; Neurotoxins; Organ Specificity; Quinolinic Acid; Rats; Rats, Wistar; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.
Topics: Base Sequence; Cardiovascular System; Cell Hypoxia; Cells, Cultured; Cobalt; DNA Primers; Endothelium, Vascular; Feedback; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetics; Muscle, Smooth, Vascular; Myocardium; Procollagen-Proline Dioxygenase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2003 |
Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas.
Topics: Adolescent; Adult; Aged; Androgens; Angiogenesis Inhibitors; Animals; Blood Vessels; Castration; Cobalt; Eye Proteins; Humans; Hyperplasia; Hypoxia; In Situ Nick-End Labeling; Male; Mice; Mice, Knockout; Mice, Nude; Neoplasm Transplantation; Neovascularization, Physiologic; Nerve Growth Factors; Pancreas; Prostate; Prostatic Neoplasms; Proteins; Rats; Serpins; Tumor Cells, Cultured | 2003 |
Store-operated Ca2+ entry in first trimester and term human placenta.
Topics: Adult; Blotting, Western; Calcium; Cell Membrane; Cobalt; Cytophotometry; Diglycerides; DNA Primers; Female; Fluorometry; Humans; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Nickel; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stimulation, Chemical; Trophoblasts | 2003 |
Acute intravesical infusion of a cobalt solution stimulates a hypoxia response, growth and angiogenesis in the rat bladder.
Topics: Administration, Intravesical; Animals; Blotting, Western; Cell Division; Cell Hypoxia; Cobalt; DNA-Binding Proteins; Endothelial Growth Factors; Factor VIII; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Neovascularization, Physiologic; Nuclear Proteins; Organ Size; Rats; Rats, Sprague-Dawley; Transcription Factors; Urinary Bladder; Urinary Bladder Neck Obstruction; Urothelium; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Overexpression, purification, and characterization of the recombinant leucine aminopeptidase II of Bacillus stearothermophilus.
Topics: Anilides; Cations, Divalent; Chelating Agents; Cloning, Molecular; Cobalt; Copper; Enzyme Inhibitors; Escherichia coli; Geobacillus stearothermophilus; Hydrogen-Ion Concentration; Leucyl Aminopeptidase; Mercury; Molecular Weight; Recombinant Proteins; Substrate Specificity; Temperature | 2003 |
Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Cell Movement; Cobalt; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactams, Macrocyclic; Neoplasm Invasiveness; Osmolar Concentration; Phosphoric Monoester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; PTEN Phosphohydrolase; Quinones; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2003 |
Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats.
Topics: Animals; Blotting, Western; Cobalt; Creatinine; DNA-Binding Proteins; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemia; Kidney; Macrophages; Male; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Up-Regulation | 2003 |
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway.
Topics: Active Transport, Cell Nucleus; Androstadienes; Animals; Blotting, Western; Cell Line; Cell Nucleus; Cobalt; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Reporter; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Ligases; Lymphokines; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Viral Regulatory and Accessory Proteins; Von Hippel-Lindau Tumor Suppressor Protein; Wortmannin | 2003 |
Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1alpha.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Chromones; Cobalt; Dimerization; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Genes, Dominant; Glutathione Transferase; Glycolysis; HeLa Cells; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Ligases; Luciferases; Mice; Molecular Sequence Data; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Pyrrolidines; Receptors, Aryl Hydrocarbon; RNA; Thiocarbamates; Time Factors; Transcription Factors; Transfection; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2003 |
A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chick Embryo; Chorion; Cobalt; Enzyme-Linked Immunosorbent Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microscopy, Video; Neovascularization, Pathologic; Prostatic Neoplasms; Rats; Time Factors; Transcription Factors; Tumor Suppressor Protein p53; Up-Regulation; Vascular Endothelial Growth Factor A | 2003 |
AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells.
Topics: AMP-Activated Protein Kinases; Base Sequence; Cell Hypoxia; Cell Line, Tumor; Cobalt; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Activation; Gene Expression; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Monosaccharide Transport Proteins; Multienzyme Complexes; Nuclear Proteins; Prostatic Neoplasms; Protein Serine-Threonine Kinases; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Transcription Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2003 |
Uptake of cobalt from the nasal mucosa into the brain via olfactory pathways in rats.
Topics: Administration, Intranasal; Animals; Autoradiography; Brain; Cobalt; Cobalt Radioisotopes; Functional Laterality; Injections, Intraperitoneal; Male; Nasal Mucosa; Olfactory Pathways; Rats; Rats, Sprague-Dawley | 2003 |
Cobalt injections into the pedunculopontine nuclei attenuate the reflex diaphragmatic responses to muscle contraction in rats.
Topics: Animals; Antimutagenic Agents; Blood Pressure; Cobalt; Diaphragm; Heart Rate; Male; Microinjections; Muscle Contraction; Pedunculopontine Tegmental Nucleus; Rats; Rats, Sprague-Dawley; Reflex | 2004 |
The effect of cobaltous chloride on the blood sugar and alpha cells in the pancreatic islets of the rabbit.
Topics: Animals; Blood Glucose; Cobalt; Glucagon-Secreting Cells; Islets of Langerhans; Rabbits | 1952 |
[Antianemic effect of cobalt. I. Cobaltous chloride therapy in neoplastic anemia].
Topics: Anemia; Chlorides; Cobalt; Hodgkin Disease; Ions | 1952 |
[Action of intravenous cobalt chloride on gastric secretion].
Topics: Cobalt; Digestion; Gastric Juice | 1952 |
The use of cobaltous chloride in the anemia associated with chronic renal disease.
Topics: Anemia; Cobalt; Humans; Kidney Diseases; Kidney Failure, Chronic; Renal Insufficiency, Chronic | 1953 |
[The action of cobaltous chloride on carbohydrate metabolism in normal rabbits and in rabbits with dithizone-induced diabetes].
Topics: Animals; Carbohydrate Metabolism; Carbohydrates; Cobalt; Diabetes Mellitus, Experimental; Dithizone; Lagomorpha; Rabbits | 1953 |
Cobaltous chloride therapy in sickle cell anemia.
Topics: Anemia; Anemia, Sickle Cell; Cobalt; Erythrocytes, Abnormal; Humans; Tracheophyta | 1953 |
Selective destruction of pancreatic alpha cells by cobaltous chloride in the dog; physiologic implications.
Topics: Animals; Cobalt; Dogs; Glucagon-Secreting Cells; Pancreas; Proteins | 1953 |
Vitamin B12 and cobalt chloride in growth and reproduction of four strains of mice.
Topics: Animals; Biological Phenomena; Cobalt; Corrinoids; Growth; Hematinics; Mice; Reproduction; Vitamin B 12 | 1953 |
Treatment of sickle cell anemia with cobalt chloride.
Topics: Anemia; Anemia, Sickle Cell; Cobalt; Erythrocytes, Abnormal; Humans; Tracheophyta | 1954 |
The cobalt chloride sweating test; a clinical evaluation and review of complications.
Topics: Cobalt; Dermatitis; Dermatitis, Contact; Humans; Sweating | 1954 |
The activity of extracted pancreatic hyperglycemic-glycogenolytic factor after cobaltous chloride and synthalin A.
Topics: Amidines; Cobalt; Glucagon; Guanidines; Hormones; Pancreas | 1954 |
[Effects of small doses of cobalt chloride on the pancreatic endocrine islets of the guinea pig].
Topics: Cobalt; Guinea Pigs; Islands; Islets of Langerhans | 1954 |
[Effects of cobalt chloride on alpha cells, on the glucagon content of the pancreas, and on blood sugar in the dog].
Topics: Animals; Blood Glucose; Cobalt; Dogs; Glucagon; Glucagon-Secreting Cells; Hormones; Humans; Islands; Islets of Langerhans; Pancreas; Pancreatic Hormones | 1954 |
[Studies on stability of hemopoietic factors (vitamin B12) in concentrate of liver extract and in the presence of potassium cyanide and cobalt chloride].
Topics: Cobalt; Corrinoids; Health Services; Hematinics; Liver; Liver Extracts; Potassium Cyanide; Vitamin B 12 | 1954 |
[Effect of Amanita phalloides and cobaltous chloride in the guinea pig with sclerotic pancreas].
Topics: Agaricales; Amanita; Cobalt; Guinea Pigs; Humans; Islands; Islets of Langerhans; Pancreas; Vegetables | 1954 |
[Effect of cobaltous chloride on blood sugar and islands of Langerhans in rodents].
Topics: Blood Glucose; Cobalt; Islands; Islets of Langerhans | 1954 |
[The significance of pancreas in the genesis of hyperglycemia due to cobaltous chloride].
Topics: Cobalt; Hyperglycemia; Pancreas | 1954 |
Polycythemia induced by cobalt. III. Histologic studies with evaluation of toxicity of cobaltous chloride.
Topics: Cobalt; Polycythemia | 1954 |
[Effect of injections of cobaltous chloride on glycogen reserves in the white rat].
Topics: Animals; Cobalt; Glycogen; Glycogenolysis; Injections; Rats | 1955 |
Cobaltous chloride and iodine metabolism of normal and tumor-bearing rats.
Topics: Animals; Cobalt; Iodides; Iodine; Iodine Radioisotopes; Iron; Neoplasms, Experimental; Radioisotopes; Rats; Thyroid Gland | 1955 |
Cobaltous chloride in the treatment of certain refractory anemias.
Topics: Anemia; Anemia, Refractory; Cobalt | 1955 |
Cytopathologic effects of cobalt on pancreatic islets of many species; islands of Langerhans and cobaltous chloride.
Topics: Cobalt; Islands; Islets of Langerhans | 1956 |
Goitrogenic action of cobaltous chloride in the guinea-pig.
Topics: Cobalt; Goiter; Guinea Pigs | 1955 |
[Action of cobalt chloride on the isolated gallbladder of the guinea pig].
Topics: Cobalt; Gallbladder; Guinea Pigs; Humans | 1955 |
[Experimental study of the increase of blood lipids after injection of cobalt chloride].
Topics: Cobalt; Humans; Injections; Lipids | 1956 |
[Muscular changes in alloxan diabetes and interference of cobalt chloride].
Topics: Animals; Cobalt; Diabetes Mellitus, Experimental; Disease; Muscles; Muscular Diseases | 1957 |
Alpha cell activity and its relation to glycaemic level and insulin sensitivity in albino rats; a comparative study of the action of nadisan and cobalt chloride.
Topics: Animals; Blood Glucose; Cobalt; Hypoglycemic Agents; Insulin; Insulin Resistance; Rats | 1957 |
[Mechanism of induced early hyperglycemia in the guinea pig by administration of cobaltous chloride].
Topics: Cobalt; Guinea Pigs; Hyperglycemia | 1957 |
[Effect of cobalt chloride on arterial pressure in guinea pigs].
Topics: Animals; Blood Pressure; Blood Pressure Determination; Cobalt; Guinea Pigs | 1957 |
[Effects of cobaltous chloride on the cardiovascular apparatus of the guinea pig].
Topics: Cardiovascular System; Cobalt; Guinea Pigs; Humans | 1957 |
[Effects of cobalt chloride on thyroid morphology in guinea pigs].
Topics: Animals; Cobalt; Guinea Pigs; Thyroid Gland; Viscera | 1957 |
[Changes in the lipoprotein picture in rabbits due to cobalt chloride].
Topics: Animals; Cobalt; Islands; Islets of Langerhans; Lagomorpha; Lipoproteins; Rabbits | 1957 |
[Effects of cobalt chloride on thyroid function].
Topics: Cobalt; Humans; Thyroid Gland; Viscera | 1958 |
[Effect of cobalt chloride on cardiovascular apparatus of anesthetized guinea pig].
Topics: Cardiovascular System; Cobalt; Guinea Pigs; Humans | 1958 |
[Behavior of blood cholinesterase in rabbits after administration of cobalt chloride].
Topics: Animals; Cholinesterases; Cobalt; Lagomorpha; Rabbits | 1958 |
[Changes in the blood lipid picture induced by experimental pancreatic lesions caused by cobalt chloride].
Topics: Cobalt; Disease; Humans; Lipids; Pancreas; Pancreatic Diseases | 1958 |
Extracted glucagon from dog pancreas treated with alloxan, synthalin A and cobaltous chloride.
Topics: Alloxan; Amidines; Animals; Antineoplastic Agents; Cobalt; Dogs; Glucagon; Guanidines; Pancreas | 1958 |
Treatment of eight cases of hyperthyroidism with cobaltous chloride.
Topics: Cobalt; Humans; Hyperthyroidism | 1958 |
Effect of oral and intravenous cobaltous chloride on thyroid function.
Topics: Cobalt; Humans; Thyroid Gland; Viscera | 1958 |
[Toxic action of cobalt chloride on thyroid function].
Topics: Anemia; Cobalt; Humans; Thyroid Gland | 1958 |
Influence of cobaltous chloride on aortic atheromatosis and plasma lipid pattern in cholesterol-fed chickens.
Topics: Animals; Aortic Diseases; Arteriosclerosis; Chickens; Cholesterol; Cobalt; Lipids | 1958 |
[Effects of hematic factors on hypercholesterolemia induced by cobaltous chloride].
Topics: Cholesterol; Cobalt; Heparin; Humans; Hypercholesterolemia; Serotonin; Serotonin Agents | 1958 |
[Effect of subcutaneous injection of cobalt chloride in the guinea pig].
Topics: Cobalt; Guinea Pigs; Injections, Subcutaneous | 1957 |
[Toxic action of cobalt chloride on thyroid function].
Topics: Cobalt; Humans; Thyroid Gland; Viscera | 1958 |
Experimental production of polycythemia in humans by administration of cobalt chloride.
Topics: Cobalt; Humans; Polycythemia | 1958 |
[The steatogenic action of cobaltous chloride on the liver of rabbits].
Topics: Animals; Cobalt; Lagomorpha; Liver; Rabbits | 1958 |
[Formation of anti-liver autoantibodies during the administration of cobalt chloride in white rats].
Topics: Animals; Antibodies; Autoantibodies; Cobalt; Liver; Pharmaceutical Preparations; Rats | 1958 |
[Electrophoresis of blood proteins during erythrocytosis induced by cobalt chloride in guinea pigs].
Topics: Blood Proteins; Cobalt; Electrophoresis; Guinea Pigs; Polycythemia | 1958 |
[Treatment of anemia with cobaltous chloride].
Topics: Anemia; Cobalt | 1958 |
Studies on the pharmacology of cobalt chloride.
Topics: Cobalt; Humans | 1959 |
Cobaltous chloride in the treatment of anemia associated with renal insufficiency and its effect on thyroid function.
Topics: Anemia; Cobalt; Humans; Kidney; Kidney Diseases; Renal Insufficiency; Thyroid Gland | 1959 |
Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells.
Topics: Acetylcysteine; Androstadienes; Antimutagenic Agents; Biomarkers; Cell Hypoxia; Cell Line, Tumor; Cobalt; Collagen Type XVIII; Enzyme Inhibitors; Head and Neck Neoplasms; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Humans; Imidazoles; MAP Kinase Signaling System; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Vascular Endothelial Growth Factor A; Wortmannin | 2003 |
[Presence of hemagglutinins in a serum fraction precipitated by heparin and cobaltous chloride].
Topics: Antibodies; Cobalt; Hemagglutination; Hemagglutinins; Heparin | 1960 |
Adrenocortical activities of 20-cobalto-delta-1-hydrocortisone and cobaltous chloride.
Topics: Cobalt; Hydrocortisone; Prednisolone | 1961 |
[Treatment of "refractory" anemia with cobalt chloride].
Topics: Anemia; Cobalt | 1961 |
[Effect of cobaltous chloride on glucide metabolism. I. Clinical research].
Topics: Biomedical Research; Carbohydrate Metabolism; Carbohydrates; Cobalt; Humans | 1960 |
[Behavior of pancreatic elastases and histomorphology of the islands of Langerhans in experimental cobaltous chloride poisoning. Protective action of versenate calcium (Ca Na 2 EDTA)].
Topics: Calcium, Dietary; Carbon Tetrachloride; Cobalt; Edetic Acid; Endopeptidases; Islands; Islets of Langerhans; Pancreas; Pancreatic Elastase; Peptide Hydrolases | 1960 |
[Effect of cobaltous chloride on glucide metabolism. II. Experimental research].
Topics: Carbohydrate Metabolism; Carbohydrates; Cobalt | 1960 |
[The standard determination of cobaltous chloride according to the Dutch pharmacopoeia, fifth edition].
Topics: Chlorides; Cobalt | 1960 |
Observations on the metabolic and histological effects of cobalt chloride in the rabbit, with particular reference to cobalt-induced hypercholesterolaemia.
Topics: Animals; Cholesterol; Cobalt; Hypercholesterolemia; Rabbits | 1959 |
[Turbidimetric determination of gamma globulins after precipitation by heparin and cobaltous chloride].
Topics: Climate; Cobalt; gamma-Globulins; Heparin; Immune System Phenomena; Nephelometry and Turbidimetry | 1959 |
[On the mechanism of alpha-cytotoxic action of cobaltous chloride].
Topics: Chlorides; Cobalt; Islands; Islets of Langerhans | 1960 |
[Study of hematologic changes in experimental poisoning by cobalt acetate and cobaltous chloride].
Topics: Acetates; Cobalt; Hemoglobins | 1961 |
[The effects of chelators in the course of experimental poisoning by cobaltous chloride. (I.)].
Topics: Chelating Agents; Cobalt; Humans | 1961 |
Pancreatic islet cells in the normal and cobaltous chloride-treated guinea-pig. A fine structural study.
Topics: Cobalt; Epithelial Cells; Guinea Pigs; Islets of Langerhans; Pancreas, Exocrine | 1961 |
[Influence of cobalt chloride on thrombocythemia, on prothrombin time and on the plasma thromboelastogram].
Topics: Blood Platelets; Cobalt; Plasma; Prothrombin Time; Thrombelastography; Thrombocytosis; Thromboplastin | 1962 |
Experimental production of hyperlipemia in rabbits by cobaltous chloride.
Topics: Animals; Cobalt; Hyperlipidemias; Rabbits | 1963 |
[EFFECT OF COBALT CHLORIDE ON THE GUINEA PIG WITH SPECIAL REFERENCE TO THE LIVER].
Topics: Acid Phosphatase; Adrenal Glands; Alkaline Phosphatase; Animals; Blood Glucose; Bone and Bones; Central Nervous System; Chlorides; Cobalt; DNA; Electron Transport Complex IV; Guinea Pigs; Kidney; Lipid Metabolism; Liver; Liver Glycogen; Muscles; Oxidoreductases; Pancreas; Pharmacology; Phosphoric Monoester Hydrolases; Phosphotransferases; Pituitary Gland; Research; RNA; Toxicology | 1963 |
INTRADERMAL TEST USING COBALT CHLORIDE.
Topics: Cobalt; Humans; Hypersensitivity; Intradermal Tests; Nickel; Skin Tests | 1963 |
ABSORPTION OF RADIOACTIVE COBALTOUS CHLORIDE IN HUMAN SUBJECTS.
Topics: Absorption; Autoradiography; Blood Protein Electrophoresis; Chlorides; Chromatography; Cobalt; Cobalt Isotopes; Metabolism; Proteins; Serum Albumin; Urine | 1963 |
FACTORS AFFECTING THE FORMATION OF COBAMIDE COENZYMES IN CLOSTRIDIUM TETANOMORPHUM.
Topics: Bacteriological Techniques; Benzimidazoles; Clostridium tetani; Clostridium tetanomorphum; Cobalt; Cobamides; Coenzymes; Glucose; Glutamates; Histidine; Methionine; Phosphates; Potassium Compounds; Proteins; Research | 1964 |
LIPID MOBILIZER HORMONE IN COBALT CHLORIDE HYPERLIPEMIA.
Topics: Cholesterol; Cobalt; Fatty Acids; Glycerides; Hyperlipidemias; Lipids; Lipoprotein Lipase; Liver; Pituitary Hormones; Pituitary Hormones, Posterior; Rabbits; Research; Toxicology | 1965 |
EFFECT OF COBALTOUS CHLORIDE ON THE MINIMAL CARCINOGENIC DOSE OF METHYLCHOLANTHRENE IN ALBINO MICE.
Topics: Animals; Carcinogens; Chlorides; Cobalt; Methylcholanthrene; Mice; Neoplasms; Pharmacology; Research | 1965 |
[EFFECT OF COBALT CHLORIDE ON THE ANTIBIOTIC SENSITIVITY OF ESCHERICHIA COLI].
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cobalt; Dermatologic Agents; Escherichia coli; Research | 1964 |
[COBALT CHLORIDE FOR THE DEMONSTRATION OF ORGANIC PHOSPHORUS ESTERS ON PAPER- AND ESPECIALLY THIN-LAYER CHROMATOGRAPHY].
Topics: Chromatography; Chromatography, Thin Layer; Cobalt; Esters; Indicators and Reagents; Phosphates; Phosphites; Phosphorus; Phosphorus, Dietary; Research | 1965 |
The hematopoletic and goltrogenic effects of cobaltous chloride in patients with sickle cell anemia.
Topics: Anemia; Anemia, Sickle Cell; Child; Cobalt; Goiter; Hemoglobins; Humans; Infant; Thyroid Gland | 1955 |
Cobalt chloride and the alpha-cells of the pancreas.
Topics: Cobalt; Glucagon-Secreting Cells; Islands; Islets of Langerhans; Pancreas | 1955 |
Effect of cobaltous chloride on the blood sugar level and the islet cells in rats.
Topics: Animals; Blood Glucose; Cobalt; Islands; Islets of Langerhans; Rats | 1959 |
Effect of cobaltous chloride, synthaline A and IPTD on the islets of Langerhans studied by means of vital staining.
Topics: Cobalt; Hypoglycemic Agents; Islands; Islets of Langerhans; Research; Staining and Labeling | 1959 |
[The detection of iron as a contaminant of cobaltous chloride].
Topics: Cobalt; Iron | 1959 |
[Attempted cobalt chloride therapy of hypothalamic disorders].
Topics: Chlorides; Cobalt; Disease; Hypothalamic Diseases; Hypothalamus; Ions | 1962 |
Both calcium and ROS as common signals mediate Na(2)SeO(3)-induced apoptosis in SW480 human colonic carcinoma cells.
Topics: Acetylcysteine; Aniline Compounds; Apoptosis; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Catalase; Cell Line, Tumor; Cell Size; Cell Survival; Cobalt; Colonic Neoplasms; Dithiothreitol; DNA Fragmentation; Dose-Response Relationship, Drug; Egtazic Acid; Flow Cytometry; Fluoresceins; Glutathione; Humans; Membrane Potentials; Mitochondria; Reactive Oxygen Species; Ruthenium Red; Sodium Selenite; Xanthenes | 2003 |
Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons.
Topics: Amino Acid Transport System ASC; Cell Line; Cobalt; Computer Systems; Deferoxamine; Down-Regulation; Female; Gene Products, env; Humans; Hypoxia; In Vitro Techniques; Iron Chelating Agents; Minor Histocompatibility Antigens; Placenta; Polymerase Chain Reaction; Pregnancy; Pregnancy Proteins; RNA, Messenger; Transcription, Genetic; Trophoblasts | 2003 |
Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha.
Topics: Antigens, CD; Cell Differentiation; Cell Division; Cell Hypoxia; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Molsidomine; Transcription Factors; Tumor Cells, Cultured; U937 Cells | 2003 |
Oral lichenoid reaction due to chromate/cobalt in dental prosthesis.
Topics: Antimutagenic Agents; Cobalt; Denture, Partial; Humans; Irritants; Lichen Planus, Oral; Male; Middle Aged; Nickel; Potassium Dichromate | 2003 |
Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase activation in human cervical cancer HeLa cells.
Topics: Apoptosis; Cobalt; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins c-jun; Transcription Factors | 2003 |
Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma.
Topics: Antimutagenic Agents; Antineoplastic Agents, Hormonal; Cobalt; Female; Gonadal Steroid Hormones; Gonadotropin-Releasing Hormone; Humans; Leiomyoma; Leuprolide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Tumor Cells, Cultured; Ultrasonography, Doppler, Color; Up-Regulation; Uterine Neoplasms | 2003 |
Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cobalt; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA-Binding Proteins; Hepatocytes; Hypoxia; Hypoxia-Inducible Factor 1; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Nuclear Proteins; Oligonucleotide Probes; Organometallic Compounds; Pregnane X Receptor; Protein Binding; Rabbits; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Up-Regulation | 2003 |
Genistein suppressed upregulation of vascular endothelial growth factor expression by cobalt chloride and hypoxia in rabbit retinal pigment epithelium cells.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Genistein; Pigment Epithelium of Eye; Rabbits; Up-Regulation; Vascular Endothelial Growth Factor A | 2003 |
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.
Topics: Activating Transcription Factor 4; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cobalt; Cysteine Endopeptidases; Deferoxamine; DNA-Binding Proteins; Electron Transport; Glucose; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron Chelating Agents; Mitochondria; Multienzyme Complexes; Mutation; Nuclear Proteins; Oxygen; Plasmids; Potassium Cyanide; Proteasome Endopeptidase Complex; Ribonucleases; RNA Interference; RNA, Messenger; Time Factors; Transcription Factor CHOP; Transcription Factors; Transfection; Tunicamycin | 2004 |
Surround antagonism in macaque cone photoreceptors.
Topics: Animals; Calcium; Calcium Channels; Chloride Channels; Chlorides; Cobalt; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Macaca fascicularis; Macaca mulatta; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Photic Stimulation; Retinal Cone Photoreceptor Cells; Visual Fields | 2003 |
Oxygen tension regulates the expression of a group of procollagen hydroxylases.
Topics: Animals; Cells, Cultured; Cobalt; Deferoxamine; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Enzymologic; Hypoxia; Mice; Muscle, Smooth, Vascular; Oxygen; Procollagen; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Procollagen-Proline Dioxygenase; Rats; RNA, Messenger | 2003 |
Foetal rat lung epithelial (FRLE) cells: partial characterisation and response to pneumotoxins.
Topics: Animals; Bromobenzenes; Cadmium Chloride; Cell Line; Cobalt; Cytotoxins; Drug Evaluation, Preclinical; Epithelial Cells; Fetus; Gene Expression; Humans; Hydrogen Peroxide; In Situ Hybridization; Keratins; Lung; Mice; Microsomes, Liver; Naphthalenes; Neutral Red; Nitro Compounds; Nitrofurantoin; Paraquat; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Rats; RNA, Messenger | 2004 |
Effect of hypoxia on monocyte chemotactic protein-1 (MCP-1) gene expression induced by Interleukin-1beta in human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chemokine CCL2; Cobalt; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression Regulation; Humans; Hypoxia; Inflammation; Interleukin-1; Knee; Osteoarthritis; Polymerase Chain Reaction; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; Time Factors | 2003 |
Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Oxygen; Procollagen-Proline Dioxygenase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic | 2003 |
Maturation of spiking activity in trout retinal ganglion cells coincides with upregulation of Kv3.1- and BK-related potassium channels.
Topics: Aging; Analgesics, Non-Narcotic; Animals; Antimutagenic Agents; Blotting, Northern; Cobalt; Dose-Response Relationship, Radiation; Eggs; Elapid Venoms; Electric Stimulation; Gene Expression Regulation, Developmental; In Vitro Techniques; Larva; Membrane Potentials; Neurons; Neuropeptides; Oncorhynchus mykiss; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Quinine; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shaw Potassium Channels; Tetraethylammonium | 2004 |
Hypoxic regulation of angiopoietin-2 expression in endothelial cells.
Topics: Angiopoietin-2; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Cobalt; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Deferoxamine; Dinoprostone; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Iron Chelating Agents; Isoenzymes; Lactones; Membrane Proteins; Nuclear Proteins; Oligonucleotides, Antisense; Oxygen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Recombinant Proteins; RNA, Messenger; Sulfones; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
Hypoxia and estrogen receptor profile influence the responsiveness of human breast cancer cells to estradiol and antiestrogens.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Hypoxia; Cobalt; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Receptors, Estrogen; Tamoxifen; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2004 |
Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.
Topics: Amino Acid Substitution; Base Sequence; Carcinoma, Renal Cell; Cobalt; DNA Primers; DNA-Binding Proteins; Genes, Tumor Suppressor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms; Mutation; Nuclear Receptor Subfamily 4, Group A, Member 1; Pro-Opiomelanocortin; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein | 2004 |
Preferential transcription of rabbit Aldh1a1 in the cornea: implication of hypoxia-related pathways.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Cobalt; Cornea; Environmental Pollutants; Genes, Reporter; Humans; Hypoxia; Isoenzymes; Mice; Mice, Transgenic; Organ Specificity; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Rabbits; Rats; Retinal Dehydrogenase | 2004 |
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
Topics: Antigens, Neoplasm; Catalysis; Cations, Divalent; Cell Line, Tumor; Cells, Cultured; Cobalt; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Superhelical; Etoposide; Humans; Magnesium; Mutagens | 2004 |
Expression of the pro-angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endoplasmic reticulum stress.
Topics: Adenocarcinoma; Amino Acids; Breast Neoplasms; CCAAT-Enhancer-Binding Proteins; Cell Hypoxia; Cobalt; DNA Damage; DNA, Neoplasm; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Humans; Interleukin-8; Neovascularization, Pathologic; RNA, Messenger; RNA, Neoplasm; Transcription Factor CHOP; Transcription Factors; Tumor Cells, Cultured; Tunicamycin; Up-Regulation; Vascular Endothelial Growth Factors | 2004 |
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; Dimerization; DNA; Epithelial Cells; Genes, Dominant; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Lung; Oxygen; Promoter Regions, Genetic; Protein Biosynthesis; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic | 2004 |
Transdifferentiation of cultured tubular cells induced by hypoxia.
Topics: Actins; Animals; Antimutagenic Agents; Atmosphere Exposure Chambers; Cell Differentiation; Cell Line, Transformed; Cell Movement; Chronic Disease; Cobalt; Collagen Type I; Desmin; Epithelial Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules, Proximal; Phenotype; Rats; Transcription Factors; Vimentin | 2004 |
[Polarographic studies. XV. Polarographic behavior of arginine in buffered solution of cobalt chloride].
Topics: Arginine; Buffers; Cobalt; Humans; Polarography; Solutions | 1951 |
Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Cell Survival; Cobalt; Deferoxamine; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Neuroprotective Agents; Nuclear Proteins; Oligonucleotides; Rats; Transcription Factors | 2004 |
Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.
Topics: Animals; Benzylamines; Brain; Calcium; Calcium Channel Blockers; Capillaries; Cell Hypoxia; Cell Line; Chelating Agents; Cobalt; Curcumin; Deferoxamine; Egtazic Acid; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Mice; Recombinant Proteins; RNA, Messenger; Sulfonamides; Triose-Phosphate Isomerase; Up-Regulation | 2004 |
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Hypoxia; Cell Line, Tumor; Cobalt; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Oxidative Stress; Polymerase Chain Reaction; tert-Butylhydroperoxide; Transcription Factors | 2004 |
Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19.
Topics: Autocrine Communication; Blotting, Western; Choroidal Neovascularization; Cobalt; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Pigment Epithelium of Eye; Recombinant Proteins; Time Factors; Transcription Factors; Vascular Endothelial Growth Factor A | 2004 |
Norepinephrine upregulates vascular endothelial growth factor in rat cardiac myocytes by a paracrine mechanism.
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alternative Splicing; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cells, Cultured; Cobalt; Culture Media, Conditioned; Gene Expression Regulation; Genetic Variation; Myocytes, Cardiac; Norepinephrine; Paracrine Communication; Prazosin; Propranolol; Protein Isoforms; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Vascular Endothelial Growth Factor A | 2003 |
Time-course changes in VEGF expression and capillarity in the early stage of exercise training with Co treatment in rat skeletal muscles.
Topics: Animals; Antimutagenic Agents; Body Weight; Capillaries; Cobalt; Female; Muscle, Skeletal; Neovascularization, Physiologic; Organ Size; Physical Conditioning, Animal; Rats; Rats, Wistar; Time Factors; Vascular Endothelial Growth Factor A | 2004 |
Medial prefrontal cortex modulation of the baroreflex parasympathetic component in the rat.
Topics: Anesthetics, Local; Animals; Baroreflex; Cardiovascular System; Cobalt; Depression, Chemical; Lidocaine; Male; Microinjections; Nerve Block; Nitroprusside; Parasympathetic Nervous System; Prefrontal Cortex; Rats; Rats, Wistar; Synaptic Transmission; Tachycardia | 2004 |
Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells.
Topics: Animals; Base Sequence; Cell Hypoxia; Cobalt; DNA Primers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucosephosphate Dehydrogenase; Kinetics; PC12 Cells; Polymerase Chain Reaction; Rats; RNA, Neoplasm | 2004 |
Oxidative mechanisms of poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo and in vitro correlations.
Topics: Animals; Antioxidants; Biocompatible Materials; Biodegradation, Environmental; Butylated Hydroxytoluene; Cobalt; Drug Stability; Hydrogen Peroxide; In Vitro Techniques; Materials Testing; Microscopy, Electron, Scanning; Oxidation-Reduction; Polymers; Polyurethanes; Spectroscopy, Fourier Transform Infrared; Surface Properties | 2004 |
Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver.
Topics: Aging; Amino Acid Sequence; Animals; Aryldialkylphosphatase; Calcium; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Cell Death; Chlorides; Cobalt; Coumarins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Firefly Luciferin; Hepatocytes; Hydrolysis; Intracellular Signaling Peptides and Proteins; Isoflurophate; Lactones; Liver; Magnesium Chloride; Male; Manganese Compounds; Mice; Mice, Knockout; Molecular Sequence Data; Paraoxon; Protein Binding; Rats; Rats, Wistar; Sequence Homology, Amino Acid; Substrate Specificity; Sulfotransferases | 2004 |
Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.
Topics: Acetylcysteine; Androstadienes; Animals; Blotting, Western; Cell Nucleus; Chromones; Cobalt; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microscopy, Fluorescence; Models, Biological; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Plasmids; Potassium Chloride; Rabbits; Reactive Oxygen Species; Time Factors; Trachea; Transcription Factors; Transcription, Genetic; Transfection; Wortmannin | 2004 |
[C-reactive protein inhibits the expression of hypoxia-inducible factor-1alpha in human umbilical vein endothelial cells in hypoxic condition].
Topics: Blotting, Western; C-Reactive Protein; Cell Hypoxia; Cells, Cultured; Cobalt; DNA-Binding Proteins; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Transcription Factors | 2004 |
Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.
Topics: Animals; Animals, Outbred Strains; Antimutagenic Agents; Cobalt; Coronary Circulation; DNA; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred ICR; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Transcription Factor AP-1; Transcription Factors | 2004 |
Selective and effective bactericidal activity of the cobalt (II) cation against Helicobacter pylori.
Topics: Cations, Divalent; Cobalt; Dose-Response Relationship, Drug; Helicobacter pylori; Humans; Microbial Sensitivity Tests; Nickel | 2004 |
The role of hypoxia inducible factor 1alpha in cobalt chloride induced cell death in mouse embryonic fibroblasts.
Topics: Animals; Blotting, Western; Caspases; Cell Death; Cell Line; Cell Shape; Cobalt; DNA-Binding Proteins; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Genes, bcl-2; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Nuclear Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Transcription Factors | 2004 |
Possible involvement of pyruvate kinase in acquisition of tolerance to hypoxic stress in glial cells.
Topics: Antimutagenic Agents; Apoptosis; Astrocytoma; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Gel, Two-Dimensional; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Iron Chelating Agents; Mutagenesis; Neuroglia; Oxidative Stress; Pyruvate Kinase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, Protein; Stress, Physiological; Time Factors; Transcriptional Activation; Transfection; Vascular Endothelial Growth Factor A | 2004 |
6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia.
Topics: Animals; Binding Sites; Biotinylation; Blotting, Western; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; Deferoxamine; Enhancer Elements, Genetic; Fructosediphosphates; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Glycine; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Luciferases; Mice; Models, Genetic; Oligonucleotides; Oxygen; Phosphofructokinase-2; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Software; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Up-Regulation | 2004 |
Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase 1/2 activation in rat C6 glioma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Size; Cobalt; DNA Fragmentation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nuclear Proteins; Rats; Transcription Factors | 2004 |
Involvement of mitochondrial- and Fas-mediated dual mechanism in CoCl2-induced apoptosis of rat PC12 cells.
Topics: Animals; Apoptosis; Caspases; Cobalt; Dose-Response Relationship, Drug; fas Receptor; Mitochondria; PC12 Cells; Rats; Receptors, Tumor Necrosis Factor | 2004 |
Induction of glucose transporter 1 expression through hypoxia-inducible factor 1alpha under hypoxic conditions in trophoblast-derived cells.
Topics: Blotting, Northern; Cell Line, Tumor; Cobalt; Deoxyglucose; Female; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Monosaccharide Transport Proteins; Oxygen; Pregnancy; Response Elements; RNA, Messenger; Transcription Factors; Trophoblasts | 2004 |
Mediation of the in vitro cytotoxicity of green and black tea polyphenols by cobalt chloride.
Topics: Cell Line; Cell Survival; Cobalt; Epithelial Cells; Flavonoids; Gingiva; Humans; Hydrogen Peroxide; Neutral Red; Oxidants; Phenols; Polyphenols; Tea | 2005 |
REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Chromones; Cobalt; Dimethyl Sulfoxide; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; RNA, Antisense; Signal Transduction; Sirolimus; Transcription Factors; Up-Regulation | 2005 |
c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia.
Topics: Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Hypoxia; Cobalt; Enzyme Activation; Genes, MDR; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation | 2004 |
Active site rearrangement of the 2-hydrazinopyridine adduct in Escherichia coli amine oxidase to an azo copper(II) chelate form: a key role for tyrosine 369 in controlling the mobility of the TPQ-2HP adduct.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Azo Compounds; Binding Sites; Cations, Divalent; Chelating Agents; Cobalt; Copper; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Phenylalanine; Pyridones; Resorcinols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Tyrosine | 2005 |
[Effect of hypoxia on production and secretion of matrix metalloproteinases in tumor cells].
Topics: Cell Hypoxia; Cell Line, Tumor; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pancreatic Neoplasms; RNA, Messenger | 2005 |
Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells.
Topics: Antimutagenic Agents; Breast Neoplasms; Cobalt; DNA-Binding Proteins; Down-Regulation; Estrogen Receptor alpha; Female; Herpes Simplex Virus Protein Vmw65; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Protein Biosynthesis; Recombinant Fusion Proteins; Transcription Factors | 2005 |
Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation.
Topics: Basic Helix-Loop-Helix Transcription Factors; Bezafibrate; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cobalt; DNA-Binding Proteins; Fatty Acid-Binding Proteins; Female; Fetus; Humans; Hypolipidemic Agents; L-Lactate Dehydrogenase; Ligands; Linoleic Acid; Maternal-Fetal Exchange; Peroxisome Proliferator-Activated Receptors; Placenta; Pregnancy; Protein Isoforms; Transcription Factors; Trophoblasts | 2005 |
Intrathecal gene delivery of glial cell line-derived neurotrophic factor ameliorated paraplegia in rats after spinal ischemia.
Topics: Adenoviridae; Animals; Behavior, Animal; Blotting, Western; Cell Death; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gait Disorders, Neurologic; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Inflammation; Male; Nerve Growth Factors; Neurons; Paraplegia; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Ischemia; Synaptophysin; Time Factors | 2005 |
Effect of divalent metal ions on DNA studied by capillary electrophoresis.
Topics: Cations, Divalent; Chlorides; Cobalt; DNA; DNA Fingerprinting; Electrophoresis, Capillary; Ferrous Compounds; Hydrogen-Ion Concentration; Nickel; Polylysine; Spectrometry, Fluorescence; Spermine; Zinc Compounds | 2005 |
Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Transformed; Cobalt; Cytoprotection; DNA-Binding Proteins; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning; Molecular Sequence Data; Neoplasm Proteins; Nuclear Proteins; Rats; Rats, Inbred BN; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Signal Transduction; Transcription Factors; Up-Regulation | 2005 |
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
Topics: Autoradiography; Cell Line, Tumor; Chromatin Immunoprecipitation; Cobalt; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Luciferases; Male; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Nuclear Proteins; Pancreatic Neoplasms; Phosphorylation; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; RNA, Messenger; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2005 |
Functional erythropoietin autocrine loop in melanoma.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Cobalt; Coloring Agents; Culture Media, Conditioned; Disease Progression; Dose-Response Relationship, Drug; Erythropoietin; Humans; Hypoxia; Immunohistochemistry; MAP Kinase Signaling System; Melanocytes; Melanoma; Membrane Potentials; Mitochondria; Phosphorylation; Receptors, Erythropoietin; Tetrazolium Salts; Thiazoles; Trypan Blue | 2005 |
Overexpression of Endothelin-A-receptor in breast cancer: regulation by estradiol and cobalt-chloride induced hypoxia.
Topics: Adult; Aged; Aged, 80 and over; Antimutagenic Agents; Blotting, Western; Breast Neoplasms; Cobalt; Disease Progression; Estradiol; Female; Humans; Immunohistochemistry; Middle Aged; Receptor, Endothelin A; Receptor, Endothelin B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation | 2005 |
Activation of sphingomyelinase from Bacillus cereus by Zn2+ hitherto accepted as a strong inhibitor.
Topics: Bacillus cereus; Binding Sites; Catalysis; Chlorides; Cobalt; Copper; Enzyme Activation; Hydrogen-Ion Concentration; Hydrolysis; Ions; Kinetics; Manganese; Models, Biological; Models, Chemical; Protein Binding; Sphingomyelin Phosphodiesterase; Zinc; Zinc Compounds | 2005 |
[Study on the interaction of metal ion in active center of superoxide dismutase with cobalt chloride by visible spectroscopy].
Topics: Buffers; Catalytic Domain; Cobalt; Hydrogen-Ion Concentration; Protein Binding; Spectrum Analysis; Superoxide Dismutase; Zinc | 1997 |
[Study on the Co(DC)2-NaDC mixed micelle system].
Topics: Bile Acids and Salts; Cobalt; Deoxycholic Acid; Humans; Micelles; Models, Molecular; Spectroscopy, Fourier Transform Infrared | 1999 |
[Study on the interaction of Cu2Zn2SOD with CoCl2, Co(His)n by spectral and magnetic resonance analysis].
Topics: Cobalt; Histidine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Metalloproteins; Metals; Protein Binding; Superoxide Dismutase | 1999 |
[Impact of hypoxia on taxol-induced apoptosis in human ovarian cancer cell line A2780 and its mechanism].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cobalt; Drug Resistance, Neoplasm; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ovarian Neoplasms; Paclitaxel; RNA, Messenger | 2005 |
Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Blood Vessels; Catalase; Cobalt; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Induction; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immunohistochemistry; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protoporphyrins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Vasodilator Agents | 2005 |
Genistein inhibited hypoxia-inducible factor-1alpha expression induced by hypoxia and cobalt chloride in human retinal pigment epithelium cells.
Topics: Cell Hypoxia; Cell Line; Cobalt; Culture Media; Dose-Response Relationship, Drug; Epithelial Cells; Genistein; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microscopy, Confocal; Pigment Epithelium of Eye; Time Factors; Transcription Factors | 2005 |
Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells.
Topics: Animals; Astrocytes; Cell Death; Cell Line, Tumor; Cell Survival; Cobalt; Deferoxamine; DNA-Binding Proteins; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mimosine; Nitro Compounds; Nuclear Proteins; Propionates; Rats; Signal Transduction; Transcription Factors | 2005 |
Taicatoxin inhibits the calcium-dependent slow motility of mammalian outer hair cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Movement; Cobalt; Culture Media; Dose-Response Relationship, Drug; Elapid Venoms; Guinea Pigs; Hair Cells, Auditory, Outer; Intracellular Membranes; Ionomycin; Nifedipine; Potassium; Potassium Channel Blockers | 2005 |
A practical approach to the degradation of polychlorinated biphenyls in transformer oil.
Topics: Catalysis; Chlorine; Cobalt; Electricity; Industrial Oils; Industrial Waste; Microchemistry; Nickel; Oils; Oxidation-Reduction; Polychlorinated Biphenyls; Sodium Compounds; Titanium; Waste Management | 2005 |
alpha-Adrenergic and muscarinic cholinergic receptors are not involved in the modulation of the parasympathetic baroreflex by the medial prefrontal cortex in rats.
Topics: Animals; Atropine; Baroreflex; Cobalt; Dioxanes; Idazoxan; Male; Parasympathetic Nervous System; Phenylephrine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 2005 |
Oxidative and hydrolytic stability of a novel acrylic terpolymer for biomedical applications.
Topics: Acrylic Resins; Biocompatible Materials; Buffers; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Cobalt; Elastomers; Hydrogen Peroxide; Hydrolysis; Lysosomes; Magnetic Resonance Spectroscopy; Materials Testing; Methacrylates; Methylmethacrylate; Oxidation-Reduction; Phospholipases A; Phospholipases A2; Polymethyl Methacrylate; Sterol Esterase; Tensile Strength | 2005 |
Cobalt chloride induces neurite outgrowth in rat pheochromocytoma PC-12 cells through regulation of endothelin-2/vasoactive intestinal contractor.
Topics: Animals; Antimutagenic Agents; Antioxidants; Cell Differentiation; Cell Division; Cobalt; Endothelin-1; Endothelin-2; Gene Expression; Intercellular Signaling Peptides and Proteins; Interleukin-6; Neurites; PC12 Cells; Peptides; Rats; Reactive Oxygen Species | 2005 |
Skeletal muscle HIF-1alpha expression is dependent on muscle fiber type.
Topics: Animals; Atrophy; Blotting, Western; Cell Hypoxia; Cells, Cultured; Cobalt; Energy Metabolism; Glycolysis; Hindlimb; Hindlimb Suspension; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxygen; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell.
Topics: Adaptation, Physiological; Adenosine Triphosphatases; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cobalt; DNA-Binding Proteins; DNA, Mitochondrial; Ethidium; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetics; Mitochondria; Mitochondrial Proteins; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation; Polymerase Chain Reaction; Transcription Factors; Transcription, Genetic | 2005 |
Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cobalt; Deferoxamine; DNA-Binding Proteins; Flow Cytometry; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Necrosis; Nuclear Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors | 2005 |
Crystal structures and magnetic properties of complexes of M(II)Cl2 (M = Cu, Ni, and Co) coordinated with 4-(N-tert-butyloxyamino)-2-(methoxymethylenyl)pyridine: 2D magnetic anisotropy of the aminoxyl-Co(II) complex in the crystalline state.
Topics: Cobalt; Copper; Crystallization; Magnetics; Models, Molecular; Molecular Structure; Nickel; Pyridines | 2005 |
Direct effect of CoC12 and NiCl2 on citrate uptake by the rat renal brush border membrane.
Topics: Animals; Biological Transport, Active; Citrates; Cobalt; Emollients; Kidney; Male; Microvilli; Nickel; Rats; Rats, Wistar | 2005 |
Hypoxia-inducible factor 1alpha modulates adhesion, migration, and FAK phosphorylation in vascular smooth muscle cells.
Topics: Adenoviridae; Animals; Aorta; Blotting, Western; Cattle; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; DNA, Complementary; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Luciferases; Microscopy, Fluorescence; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing | 2005 |
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.
Topics: Animals; Apoptosis; Blast Crisis; Bone Marrow; Cell Differentiation; Cell Hypoxia; Cobalt; Graft vs Leukemia Effect; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Liver; Macrophage-1 Antigen; Mice; Mice, Transgenic; Models, Animal; Myeloid Cells; Neoplasm Proteins; Oncogene Proteins, Fusion; Receptors, Chemokine; Spleen; Survival Rate; Tumor Cells, Cultured | 2006 |
Involvement of the periaqueductal gray in the hypotensive response evoked by L-glutamate microinjection in the lateral hypothalamus of unanesthetized rats.
Topics: Animals; Anti-Arrhythmia Agents; Cobalt; Glutamic Acid; Hypotension; Hypothalamus; Injections, Intraventricular; Lidocaine; Male; Microinjections; Neural Pathways; Neurons; Periaqueductal Gray; Rats; Rats, Wistar | 2005 |
Occupational asthma caused by cobalt chloride in a diamond polisher after cessation of occupational exposure: a case report.
Topics: Adult; Air Pollutants, Occupational; Asthma; Cobalt; Diamond; Dust; Humans; Inhalation Exposure; Male; Medical History Taking; Nasal Lavage Fluid; Nasal Provocation Tests; Occupational Diseases; Occupational Exposure; Respiratory Function Tests; Skin Tests | 2005 |
Glutamate-induced oxidative stress, but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells.
Topics: Animals; Calcium; Calcium Chloride; Caspase 3; Caspases; Cell Count; Cell Death; Cell Line; Cell Survival; Chelating Agents; Cobalt; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Extracellular Space; Glutamic Acid; Mice; Neurons; Oligopeptides; Oxidative Stress; Reactive Oxygen Species | 2006 |
Cobalt chloride administration in athletes: a new perspective in blood doping?
Topics: Cell Hypoxia; Cobalt; Doping in Sports; Erythropoiesis; Genetic Therapy; Hematinics; Humans; Hypoxia-Inducible Factor 1; Oxygen; Substance Abuse Detection | 2005 |
Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism.
Topics: Cell Cycle; Cobalt; DNA Damage; Flow Cytometry; HeLa Cells; Humans; Long Interspersed Nucleotide Elements; Magnesium; Nickel; Promoter Regions, Genetic; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic | 2005 |
Triamcinolone acetonide destabilizes VEGF mRNA in Müller cells under continuous cobalt stimulation.
Topics: Blotting, Western; Cells, Cultured; Cobalt; Dactinomycin; Down-Regulation; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neuroglia; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triamcinolone Acetonide; Vascular Endothelial Growth Factor A | 2005 |
Attenuation of oxidative stress in HL-1 cardiomyocytes improves mitochondrial function and stabilizes Hif-1alpha.
Topics: Adenosine Triphosphate; Antioxidants; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Hypoxia; Cell Line; Cobalt; Cytochromes c; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ion Channels; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Oxidative Stress; Protein Transport; Reactive Oxygen Species; RNA, Messenger | 2005 |
Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells.
Topics: Cells, Cultured; Cobalt; Endothelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Humans; Interleukin-8; Neovascularization, Physiologic; Protoporphyrins; Vascular Endothelial Growth Factor A | 2005 |
Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis.
Topics: Animals; Antibodies; Antimutagenic Agents; Apoptosis; Capillaries; Cobalt; Erythropoietin; Gene Expression Regulation; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Isoantibodies; Kidney Tubules; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Reperfusion Injury; Vascular Endothelial Growth Factor A | 2005 |
Hypoxia-simulating agents selectively stimulate arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells.
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Division; Cell Hypoxia; Cobalt; Deferoxamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Oncogene Proteins, Fusion; Oxides; Tretinoin; U937 Cells | 2005 |
Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells.
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Bone Marrow; Cell Differentiation; Cell Division; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Drug Synergism; Gene Expression Regulation, Leukemic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Oncogene Proteins, Fusion; Oxides; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; U937 Cells | 2005 |
Cobalt chloride, a hypoxia-mimicking agent, modulates redox status and functional parameters of cultured swine granulosa cells.
Topics: Analysis of Variance; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cobalt; Female; Gonadal Hormones; Granulosa Cells; Hydrogen Peroxide; Reactive Oxygen Species; Superoxide Dismutase; Swine; Vascular Endothelial Growth Factor A | 2005 |
Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms.
Topics: Base Sequence; Caspase 3; Caspase 8; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Primers; Gene Dosage; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia; Membrane Potential, Mitochondrial; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitroprusside; Proto-Oncogene Proteins c-bcl-2; U937 Cells; Vanadates | 2006 |
Noninvasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescence imaging in living transgenic mice.
Topics: Animals; Cell Hypoxia; Cobalt; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; HeLa Cells; Humans; Luciferases, Firefly; Luminescence; Mice; Mice, Transgenic; Transcription, Genetic; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Whole Body Imaging; Wound Healing | 2006 |
Allergenicity and cross-reactivity of naphthenic acid and its metallic salts in experimental animals.
Topics: Allergens; Animals; Carboxylic Acids; Chlorides; Cobalt; Cross Reactions; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Mice; Mice, Inbred BALB C; Patch Tests; Zinc Compounds | 2006 |
Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Differentiation; Cell Survival; Cells, Cultured; Cobalt; Drug Resistance, Neoplasm; Esophageal Neoplasms; Esophagus; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Light; Photochemotherapy; Photosensitizing Agents; RNA, Small Interfering | 2006 |
Coordination frameworks constructed from bipyridyl piperazine and MCl2 (M = Co, Ni, Zn): structural characterization and optical properties.
Topics: 2,2'-Dipyridyl; Chlorides; Cobalt; Crystallography, X-Ray; Hydrogen Bonding; Ions; Ligands; Metals; Molecular Conformation; Molecular Weight; Nickel; Piperazine; Piperazines; Polymers; Ultraviolet Rays; X-Rays; Zinc Compounds | 2006 |
Hypoxia and HIF-1alpha protect A549 cells from drug-induced apoptosis.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Drug Resistance, Neoplasm; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Nitrobenzenes; RNA, Small Interfering; Staurosporine; Sulfonamides | 2006 |
Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells.
Topics: Acetylcysteine; Cell Line, Tumor; Cobalt; Free Radicals; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Xanthine Oxidase | 2006 |
IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma.
Topics: Autocrine Communication; Carcinoma, Squamous Cell; Cell Cycle; Cobalt; Culture Media, Conditioned; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Models, Biological; Phosphatidylinositol 3-Kinases; Receptor, IGF Type 1; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2006 |
Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures.
Topics: Analysis of Variance; Animals; Antimutagenic Agents; Astrocytes; Blotting, Western; Cell Hypoxia; Cobalt; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fetus; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Interleukin-1; Leupeptins; Mice; Mice, Transgenic; Models, Biological; Mutagenesis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection; Vascular Endothelial Growth Factor A | 2006 |
Albumin cobalt binding and ischemia modified albumin generation: an endogenous response to ischemia?
Topics: Albumins; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning, Myocardial; Myocardial Ischemia | 2006 |
Inhibition of inflammatory nitric oxide production and epidermis damages by Saccharomycopsis Ferment Filtrate.
Topics: Animals; Biological Products; Cells, Cultured; Cobalt; Dermatitis; Gene Expression; Heme Oxygenase-1; Hemin; Humans; Inflammation; Lipopolysaccharides; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type II; Saccharomycopsis; Skin | 2006 |
Down-regulation of hepatocyte growth factor mRNA in rat cardiac myocytes under hypoxia mimicked by cobalt chloride.
Topics: Animals; Cells, Cultured; Cobalt; Disease Models, Animal; Down-Regulation; Hepatocyte Growth Factor; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2006 |
[Synergistic effects of biotic and abiotic elicitors on the production of tanshinones in Salvia miltiorrhiza hairy root culture].
Topics: Abietanes; Aminoisobutyric Acids; Bioreactors; Cobalt; Culture Media; Culture Techniques; Drug Synergism; Phenanthrenes; Plant Roots; Plants, Medicinal; Saccharomyces cerevisiae; Salvia miltiorrhiza; Silver | 2006 |
Noscapine inhibits hypoxia-mediated HIF-1alpha expression andangiogenesis in vitro: a novel function for an old drug.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Cell Line, Tumor; Cobalt; DNA Primers; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Pathologic; Noscapine; RNA, Neoplasm | 2006 |
Hypoxic-response elements in the oncolytic parvovirus Minute virus of mice do not allow for increased vector production at low oxygen concentration.
Topics: Animals; Cell Hypoxia; Cell Line; Cobalt; Genetic Vectors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Minute Virus of Mice; Promoter Regions, Genetic | 2006 |
Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells.
Topics: Apoptosis; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cobalt; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Humans; Proteome; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; U937 Cells | 2006 |
Result of standard patch test in patients suspected of having allergic contact dermatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Child; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Male; Metals, Heavy; Middle Aged; Nickel; Patch Tests; Perfume; Risk Factors; Sex Factors | 2005 |
Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride.
Topics: Amino Acid Sequence; Cell Line, Tumor; Cobalt; Electron Transport Complex IV; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Metalloendopeptidases; Molecular Sequence Data; Oxidative Phosphorylation; Protein Subunits; Von Hippel-Lindau Tumor Suppressor Protein | 2006 |
Cadmium restores in vitro splicing activity inhibited by zinc-depletion.
Topics: Animals; Cadmium Chloride; Carcinogens, Environmental; Chelating Agents; Chlorides; Cobalt; Copper; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Magnesium Chloride; Manganese Compounds; Mercuric Chloride; Nerve Tissue Proteins; Phenanthrolines; RNA Splicing; RNA-Binding Proteins; RNA, Messenger; SMN Complex Proteins; Zinc | 2006 |
Dermatitis on the knee following knee replacement: a minority of cases show contact allergy to chromate, cobalt or nickel but a causal association is unproven.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Chromates; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Knee Prosthesis; Male; Nickel; Prosthesis Design; Trace Elements | 2006 |
Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma.
Topics: Adenoviridae; AMP-Activated Protein Kinases; Arsenates; Carcinogens; Cell Line, Tumor; Cell Survival; Cobalt; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Humans; Hypoxia-Inducible Factor 1; Male; Metals; Multienzyme Complexes; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vanadates; Vascular Endothelial Growth Factor A | 2006 |
Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion.
Topics: Anti-Bacterial Agents; Cell Line; Cobalt; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunoblotting; Immunohistochemistry; Insulin-Like Growth Factor I; Ligands; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Sirolimus; Stimulation, Chemical; Transfection; Vascular Endothelial Growth Factor A | 2006 |
Purification of a moderate thermotolerant Bacillus coagulans BTS1 lipase and its properties in a hydro-gel system.
Topics: Alcohols; Alginates; Alkanes; Aluminum Chloride; Aluminum Compounds; Amines; Ammonium Chloride; Bacillus; Chemical Precipitation; Chlorides; Chromatography, DEAE-Cellulose; Cobalt; Enzymes, Immobilized; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Lipase; Magnesium Chloride; Palmitates; Solvents; Temperature | 2006 |
Erythropoietin in thyroid cancer.
Topics: Carrier Proteins; Caseins; Cathepsin D; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Erythropoietin; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Proto-Oncogene Proteins; Receptors, Erythropoietin; RNA-Binding Proteins; RNA, Messenger; Thyroid Neoplasms; Tumor Suppressor Protein p53 | 2006 |
Thoracic Surgery Directors Association Award. Cobalt chloride pretreatment attenuates myocardial apoptosis after hypothermic circulatory arrest.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Awards and Prizes; bcl-2-Associated X Protein; Blotting, Western; Cardiopulmonary Bypass; Circulatory Arrest, Deep Hypothermia Induced; Cobalt; Deferoxamine; DNA Fragmentation; Gene Expression Regulation; Genes, bcl-2; Heart; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Ischemic Preconditioning, Myocardial; Myocardium; Phosphorylation; Preanesthetic Medication; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Sus scrofa; Thoracic Surgery; United States | 2006 |
Synthesis and characterization of glibenclamide complexes of magnesium, chromium, cobalt, nickel, zinc and cadmium salts.
Topics: Cadmium Chloride; Chlorides; Chromium Compounds; Cobalt; Glyburide; Hypoglycemic Agents; Magnesium Chloride; Magnetic Resonance Spectroscopy; Metals; Nickel; Spectrophotometry, Atomic; Spectrophotometry, Infrared; Transition Temperature; Zinc Compounds | 2006 |
Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells.
Topics: Amides; Animals; Bone Marrow Cells; Cell Cycle; Cell Differentiation; Cell Proliferation; Cobalt; Down-Regulation; Drug Synergism; Echinomycin; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Intracellular Signaling Peptides and Proteins; Male; Mesenchymal Stem Cells; Mice; Neurons; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2006 |
Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.
Topics: Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Pulmonary Alveoli; Reactive Oxygen Species; Repressor Proteins; Respiratory Mucosa; RNA Stability; RNA, Messenger; Transcription Factors; Uncoupling Agents | 2006 |
Minimization of immunosuppressive therapy after islet transplantation: combined action of heme oxygenase-1 and PEGylation to islet.
Topics: Animals; Cobalt; Cyclosporine; Graft Survival; Heme Oxygenase-1; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Polyethylene Glycols; Rats; Survival Rate; Transplantation, Homologous | 2006 |
Chronic cobalt treatment decreases hyperglycemia in streptozotocin-diabetic rats.
Topics: Animals; Antimutagenic Agents; Blood Glucose; Body Weight; Cobalt; Diabetes Mellitus, Experimental; Drinking; Eating; Glucose Tolerance Test; Hyperglycemia; Male; Rats; Rats, Wistar | 2007 |
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Hypoxia; Cobalt; DNA Fragmentation; Etoposide; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 2006 |
Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol.
Topics: Alkaloids; alpha-Mannosidase; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Cobalt; Cytosol; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Humans; Immunohistochemistry; Mannosidases; Membrane Glycoproteins; Oligopeptides; Oligosaccharides; Peptides; Recombinant Fusion Proteins; RNA Interference; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swainsonine; Transfection | 2006 |
[CoCl2-induced chemotherapy resistance in SW480 cells and its mechanism].
Topics: Antimutagenic Agents; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation | 2006 |
A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride.
Topics: Animals; Cell Death; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; In Situ Nick-End Labeling; Male; Mice; Photoreceptor Cells; Retinal Degeneration; Time Factors | 2006 |
CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K/Akt pathway.
Topics: Antimutagenic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 9; Caspases; Cell Cycle; Cell Hypoxia; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Cobalt; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p27; Humans; Hypoxia-Inducible Factor 1; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; S-Phase Kinase-Associated Proteins; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured | 2006 |
[The importance of hypothermia in the preconditioning increase of ischemic tolerance to global cerebral ischemia].
Topics: Adenosine A1 Receptor Agonists; Animals; Brain; Brain Ischemia; Cobalt; Female; Hypothermia, Induced; Ischemic Preconditioning; Male; Mice; Nickel | 2006 |
Fractionation of hydrogen isotopes between crystalline hydrates and saturated solution of cobalt dichloride.
Topics: Chemical Fractionation; Cobalt; Deuterium; Hydrogen; Models, Chemical; Water | 2006 |
CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity.
Topics: Antibodies, Phospho-Specific; Casein Kinase II; Cell Hypoxia; Cobalt; Enzyme Activation; Enzyme Stability; Half-Life; HeLa Cells; Humans; Phosphoproteins; Phosphorylation; Phosphothreonine; Proteasome Inhibitors; Protein Transport; RNA-Binding Proteins; Subcellular Fractions; Thermodynamics; Triazoles; Ubiquitin-Protein Ligases | 2007 |
Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.
Topics: Basic Helix-Loop-Helix Transcription Factors; Biopsy, Needle; Cell Hypoxia; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Insulin-Like Growth Factor I; Podophyllotoxin; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma, Kaposi; Signal Transduction; Structure-Activity Relationship; Time Factors; Tumor Cells, Cultured | 2006 |
Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis.
Topics: Animals; Behavior, Animal; Brain Mapping; Cobalt; Dental Pulp; Evoked Potentials; Exploratory Behavior; Male; Mustard Plant; Neurons; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Plant Oils; Rats; Rats, Sprague-Dawley; Thalamus; Time Factors; Trigeminal Caudal Nucleus | 2006 |
Role of the medial prefrontal cortex in cardiovascular responses to acute restraint in rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiovascular System; Cobalt; Excitatory Amino Acid Antagonists; Heart Rate; Male; Microinjections; Prefrontal Cortex; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological | 2006 |
The bed nucleus of the stria terminalis modulates baroreflex in rats.
Topics: Adrenergic alpha-Agonists; Animals; Baroreflex; Blood Pressure; Cobalt; Drug Interactions; Heart Rate; Male; Microinjections; Phenylephrine; Rats; Rats, Wistar; Septal Nuclei; Time Factors | 2006 |
Involvement of medial prefrontal cortex neurons in behavioral and cardiovascular responses to contextual fear conditioning.
Topics: Analysis of Variance; Animals; Behavior, Animal; Blood Pressure; Cardiovascular System; Cobalt; Conditioning, Psychological; Electroshock; Fear; Freezing Reaction, Cataleptic; Heart Rate; Male; Microinjections; Motor Activity; Neurons; Prefrontal Cortex; Rats; Rats, Wistar | 2006 |
Diversities in hepatic HIF-1, IGF-I/IGFBP-1, LDH/ICD, and their mRNA expressions induced by CoCl(2) in Qinghai-Tibetan plateau mammals and sea level mice.
Topics: Actins; Altitude; Animals; Arvicolinae; Blotting, Western; Cobalt; Hypoxia-Inducible Factor 1; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Lagomorpha; Liver; Male; Mice; Mice, Inbred ICR; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Succinate Dehydrogenase; Tibet | 2007 |
The role of the lateral line and vision on body kinematics and hydrodynamic preference of rainbow trout in turbulent flow.
Topics: Animals; Biomechanical Phenomena; Cobalt; Darkness; Ecosystem; Feedback; Lateral Line System; Light; Models, Biological; Oncorhynchus mykiss; Swimming; Vision, Ocular | 2006 |
Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts.
Topics: Cell Hypoxia; Cells, Cultured; Cobalt; Connective Tissue Growth Factor; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; NF-kappa B; RNA, Messenger; Scleroderma, Systemic; Signal Transduction; Skin; Transfection; Transforming Growth Factor beta; Up-Regulation | 2006 |
1H, 13C and 15N NMR coordination shifts in gold(III), cobalt(III), rhodium(III) chloride complexes with pyridine, 2,2'-bipyridine and 1,10-phenanthroline.
Topics: 2,2'-Dipyridyl; Carbon Isotopes; Cobalt; Gold; Hydrogen; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Organogold Compounds; Phenanthrolines; Rhodium | 2007 |
Evaluation of functionalized silica's for the adsorptive recovery of homogenous catalysts through interaction with the metal centre.
Topics: Adsorption; Catalysis; Cobalt; Drug Interactions; Ligands; Metals; Palladium; Rhodium; Silicon Dioxide; Solvents; Temperature | 2007 |
Quantitative analysis of cytochrome C released from rice mitochondria using the adsorptive polarographic wave of guanidine modified Co(II)-cytochrome C complex.
Topics: Amino Acids; Cobalt; Cytochromes c; Guanidine; Mitochondria; Monosaccharides; Oryza; Polarography; Reproducibility of Results; Sodium Hydroxide; Sulfites | 2006 |
A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells.
Topics: Base Sequence; Cell Line, Transformed; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Chromones; Cobalt; Endothelial Cells; Endothelium, Vascular; Flavonoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Imidazoles; Interleukin-8; Molecular Sequence Data; Morpholines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; RNA, Messenger | 2006 |
Parabrachial nucleus influences the control of normal urinary bladder function and the response to bladder irritation in rats.
Topics: Action Potentials; Animals; Antimutagenic Agents; Brain Mapping; Cobalt; Electromyography; Neural Pathways; Neurons; Pons; Rats; Rats, Wistar; Urinary Bladder; Urinary Bladder Diseases; Urination | 2007 |
Removing the sting from the tail: reversible protonation of scorpionate ligands in cobalt(II) tris(carbene)borate complexes.
Topics: Boronic Acids; Chemistry, Inorganic; Cobalt; Crystallography, X-Ray; Hydrocarbons; Ligands; Magnetic Resonance Spectroscopy; Methane; Methylation; Molecular Structure; Protons | 2006 |
Studies on novel bacterial translocase I inhibitors, A-500359s. V. Enhanced production of capuramycin and A-500359 A in Streptomyces griseus SANK 60196.
Topics: Aminoglycosides; Anti-Bacterial Agents; Cobalt; Culture Media; Enzyme Inhibitors; Glucose; Maltose; Nucleosides; Streptomyces griseus | 2006 |
Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.
Topics: Amino Acids, Dicarboxylic; Animals; Astrocytes; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Oxygen; Reactive Oxygen Species | 2007 |
Inhibition by epigallocatechin gallate of CoCl2-induced apoptosis in rat PC12 cells.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Catechin; Cell Differentiation; Cobalt; DNA Fragmentation; Electrophoresis, Agar Gel; Flow Cytometry; Genes, bcl-2; Hypoxia-Ischemia, Brain; Membrane Potentials; Mitochondrial Membranes; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2007 |
Determination of zinc diethyldithiocarbamate released into artificial sweat from natural rubber latex vulcanizates by HPLC.
Topics: Chelating Agents; Chromatography, High Pressure Liquid; Cobalt; Copper Sulfate; Ditiocarb; Humans; Industry; Occupational Exposure; Rubber; Sweat | 2007 |
On-demand generation of an efficient catalyst for pyridine formation from unactivated nitriles and alpha,omega-diynes using CoCl2-6H2O, dppe, and Zn.
Topics: Catalysis; Cobalt; Ligands; Molecular Structure; Nitriles; Phenyl Ethers; Phosphines; Pyridines; Water; Zinc | 2007 |
The vicinal hydroxyl group is prerequisite for metal activation of Clostridium thermocellum acetylxylan esterase.
Topics: Acetylation; Acetylesterase; Carbohydrate Conformation; Catalysis; Clostridium thermocellum; Cobalt; Enzyme Activation; Glycosides; Protein Conformation; Streptomyces lividans; Structure-Activity Relationship; Substrate Specificity | 2007 |
Aescin protection of human vascular endothelial cells exposed to cobalt chloride mimicked hypoxia and inflammatory stimuli.
Topics: Aesculus; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Endothelium, Vascular; Escherichia coli; Escin; Fruit; Humans; Hypoxia; Inflammation; Interleukin-6; Lipopolysaccharides; Phytotherapy; Plant Extracts; Platelet Endothelial Cell Adhesion Molecule-1; Vascular Cell Adhesion Molecule-1 | 2007 |
In vitro availability of ofloxacin in presence of metals essential to human body.
Topics: Anti-Bacterial Agents; Cadmium Chloride; Calcium Chloride; Chlorides; Chromium Compounds; Cobalt; Copper; Drug Interactions; Ferric Compounds; Ferrous Compounds; Gastric Juice; Humans; Hydrogen-Ion Concentration; Magnesium Chloride; Manganese Compounds; Nickel; Ofloxacin; Solubility; Spectrophotometry, Ultraviolet; Trace Elements; Zinc Compounds | 2007 |
Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes.
Topics: Animals; Biological Transport, Active; Cartilage, Articular; Cells, Cultured; Chondrocytes; Cobalt; Deoxyglucose; Horses; Hypoxia; Lactic Acid; Matrix Metalloproteinase 2; Molecular Mimicry | 2006 |
Comment on "A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells".
Topics: Cell Hypoxia; Cells, Cultured; Cobalt; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Interleukin-8 | 2007 |
Molecular mechanism of the inhibitory effect of cobalt ion on thermolysin activity and the suppressive effect of calcium ion on the cobalt ion-dependent inactivation of thermolysin.
Topics: Acrylates; Autolysis; Calcium; Cobalt; Dipeptides; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Ions; Kinetics; Models, Biological; Thermolysin; Time Factors | 2007 |
Development of differential sensitivity of CaOv ovarian adenocarcinoma cells to antitumor agents under conditions of hypoxia.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Count; Cell Division; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Female; Humans; Ovarian Neoplasms; Vascular Endothelial Growth Factor A | 2006 |
Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib.
Topics: Celecoxib; Cell Hypoxia; Cell Line, Tumor; Cobalt; Cyclooxygenase 2 Inhibitors; Endoplasmic Reticulum Chaperone BiP; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasms; Pyrazoles; Sulfonamides; Survivin | 2007 |
Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1.
Topics: Actins; Cell Hypoxia; Cell Line, Tumor; Choriocarcinoma; Chorionic Villi; Cobalt; Cysteine Proteinase Inhibitors; Deferoxamine; Dose-Response Relationship, Drug; Female; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Oligonucleotides, Antisense; Pregnancy; Proteasome Endopeptidase Complex; Receptors, Transferrin; Time Factors; Tissue Culture Techniques; Trophoblasts; Up-Regulation | 2007 |
CoCl(2)-simulated hypoxia in skeletal muscle cell lines: Role of free radicals in gene up-regulation and induction of apoptosis.
Topics: Animals; Apoptosis; Cats; Cobalt; Dose-Response Relationship, Drug; Free Radicals; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Muscle, Skeletal; Oxygen; Rats; Reactive Oxygen Species; Up-Regulation; Vascular Endothelial Growth Factor A | 2007 |
Neuronal mdr-1 gene expression after experimental focal hypoxia: a new obstacle for neuroprotection?
Topics: Animals; Antimutagenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cobalt; Disease Models, Animal; Gene Expression; Glial Fibrillary Acidic Protein; Hypoxia; Male; Microscopy, Electron, Transmission; Neurons; Parietal Lobe; Phosphopyruvate Hydratase; Rats; Rats, Wistar | 2007 |
Activation of pericentromeric and telomeric heterochromatin in cultured lymphocytes from old individuals.
Topics: Adolescent; Adult; Age Factors; Aged, 80 and over; Aging; Chromatin; Cobalt; DNA Repair; Heterochromatin; Humans; Lymphocytes; Mutation; Oligopeptides; Sister Chromatid Exchange; Telomere | 2007 |
Selective ETAR antagonist atrasentan inhibits hypoxia-induced breast cancer cell invasion.
Topics: Antineoplastic Agents; Aspartic Acid Endopeptidases; Atrasentan; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Endothelin A Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Metalloendopeptidases; Neoplasm Invasiveness; Neoplasm Staging; Pyrrolidines; Receptor, Endothelin A; Time Factors; Up-Regulation | 2008 |
Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chlorides; Cobalt; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Impedance; Ethosuximide; Gadolinium; Glutamic Acid; Membrane Potentials; Neurons; Nifedipine; omega-Conotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium; Stroke; Zinc Compounds | 2007 |
Crosstalk between HIF-1 and ROCK pathways in neuronal differentiation of mesenchymal stem cells, neurospheres and in PC12 neurite outgrowth.
Topics: Amides; Animals; Antimutagenic Agents; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cobalt; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Hypoxia-Inducible Factor 1; Intracellular Signaling Peptides and Proteins; Mesenchymal Stem Cells; Mice; Nerve Tissue Proteins; Neurites; Neurons; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Time Factors | 2007 |
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Breast Neoplasms; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; Extracellular Matrix Proteins; Feedback, Physiological; Female; Fibronectins; Focal Adhesions; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Integrin beta3; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Neovascularization, Pathologic; Proto-Oncogene Proteins c-met; Stress Fibers; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A | 2007 |
Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells.
Topics: Adult; Cells, Cultured; Chorionic Gonadotropin; Cobalt; Data Interpretation, Statistical; Dinoprost; Dinoprostone; DNA Primers; Female; Fluorescent Dyes; Ghrelin; Humans; Luteal Cells; Luteolysis; Peptide Hormones; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A | 2007 |
High-density microfluidic arrays for cell cytotoxicity analysis.
Topics: Acrolein; Animals; BALB 3T3 Cells; Cattle; Cobalt; Cytotoxicity, Immunologic; Digitonin; Endothelial Cells; Equipment Design; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Microfluidics; Nickel; Saponins; Time Factors | 2007 |
Effect of chemical stabilizers of hypoxia-inducible factors on early lung development.
Topics: Amino Acids, Dicarboxylic; Animals; Chlorides; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Epithelial Cells; Ferric Compounds; Hypoxia-Inducible Factor 1; In Vitro Techniques; Indoles; Lung; Mice; Morphogenesis; Neovascularization, Physiologic; Pyrroles; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
CoCl2 induces protective events via the p38-MAPK signalling pathway and ANP in the perfused amphibian heart.
Topics: Animals; Atrial Natriuretic Factor; Cobalt; Heart; Heat-Shock Proteins; In Vitro Techniques; MAP Kinase Signaling System; Myocardium; p38 Mitogen-Activated Protein Kinases; Perfusion; Ranidae | 2007 |
Oxidative stress mediates CoCl(2)-induced prostate tumour cell adhesion: role of protein kinase C and p38 mitogen-activated protein kinase.
Topics: Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Imidazoles; Male; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Kinase C; Pyridines; Pyrrolidines; Reactive Oxygen Species; Thiocarbamates | 2007 |
Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells.
Topics: Antimutagenic Agents; Blotting, Northern; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cobalt; Cycloheximide; Cytochrome P-450 CYP1A1; Cytosol; Drug Antagonism; Environmental Pollutants; Enzyme Induction; Female; Gene Expression; Humans; Polychlorinated Dibenzodioxins; Protein Synthesis Inhibitors; Receptors, Aryl Hydrocarbon; RNA, Messenger; Ubiquitin-Protein Ligases | 2007 |
Nitroglycerin on contractile force in canine cardiac Purkinje fibers.
Topics: Animals; Cardiotonic Agents; Cobalt; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Methylene Blue; Muscle Strength; Myocardial Contraction; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Potassium; Potassium Channel Blockers; Purkinje Fibers; Tetraethylammonium | 2007 |
Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes.
Topics: Adipocytes; Adipokines; Adiponectin; Adult; Angiopoietin-Like Protein 4; Angiopoietins; Cell Differentiation; Cells, Cultured; Cobalt; Female; Gene Expression Regulation; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Middle Aged; Plasminogen Activator Inhibitor 1; Vascular Endothelial Growth Factor A | 2007 |
HIF stabilizing agents: shotgun or scalpel?
Topics: Amino Acids, Dicarboxylic; Animals; Cobalt; Deferoxamine; Female; Humans; Hypoxia-Inducible Factor 1; Lung; Mice; Neovascularization, Physiologic; Pregnancy; Premature Birth; Receptors, Vascular Endothelial Growth Factor | 2007 |
PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia.
Topics: Active Transport, Cell Nucleus; Animals; Cell Hypoxia; Cell Line; Cobalt; DNA-Binding Proteins; Down-Regulation; Humans; Lung; Mice; Oxidative Stress; Promoter Regions, Genetic; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein C; RNA-Binding Proteins; Transcription Factors | 2007 |
Characterization of CoCl2-induced reactive oxygen species (ROS): Inductions of neurite outgrowth and endothelin-2/vasoactive intestinal contractor in PC12 cells by CoCl2 are ROS dependent, but those by MnCl2 are not.
Topics: Animals; Cell Survival; Chlorides; Cobalt; Endothelin-2; Gene Expression; Intercellular Signaling Peptides and Proteins; Manganese Compounds; Neurites; PC12 Cells; Peptides; Rats; Reactive Oxygen Species | 2007 |
Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.
Topics: Astrocytoma; Cell Hypoxia; Cobalt; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Lipopolysaccharides; Pertussis Toxin; Phospholipase D; Phospholipases A2; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Up-Regulation | 2007 |
Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans.
Topics: Anaerobiosis; Cobalt; Cryptococcus neoformans; Fungal Proteins; Gene Dosage; Gene Expression Regulation, Fungal; Mutation; Promoter Regions, Genetic; Schizosaccharomyces; Sterols; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2007 |
Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.
Topics: Animals; Cell Hypoxia; Cobalt; DNA; Enzyme Induction; Flavonoids; Genistein; Ginkgo biloba; Ginkgolides; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Neuroprotective Agents; PC12 Cells; Plant Extracts; Rats; RNA, Messenger | 2008 |
Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha.
Topics: Active Transport, Cell Nucleus; Binding Sites; Breast Neoplasms; Cell Hypoxia; Cell Nucleus; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Leptin; p300-CBP Transcription Factors; Promoter Regions, Genetic; Protein Binding; Transcriptional Activation; Tumor Cells, Cultured | 2008 |
Extraction of Co(II) from aqueous solution using emulsion liquid membrane.
Topics: Chemistry Techniques, Analytical; Cobalt; Hexoses; Hydrogen-Ion Concentration; Kinetics; Membranes, Artificial; Oxides; Phosphines; Phosphinic Acids; Solubility; Temperature; Thiocyanates; Water | 2008 |
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1{alpha} and airway responsiveness to ACh.
Topics: Acetylcholine; Animals; Cattle; Cell Differentiation; Cells, Cultured; Cobalt; Drug Stability; Drug Synergism; Fetal Blood; Hypoxia-Inducible Factor 1; In Vitro Techniques; Muscle, Smooth; Myocytes, Smooth Muscle; Myosin Heavy Chains; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Rabbits; Reactive Oxygen Species; Serum; Signal Transduction; Trachea; Transcription, Genetic | 2007 |
uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells.
Topics: Animals; Antimutagenic Agents; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Membrane; Cell Movement; Cobalt; Collagen; Enzyme Activation; Epithelium; Female; Green Fluorescent Proteins; Humans; Hypoxia; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; Oxygen; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Snail Family Transcription Factors; Transcription Factors | 2007 |
Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress.
Topics: Altitude Sickness; Animals; Antimutagenic Agents; Antioxidants; Atmospheric Pressure; Brain; Cobalt; Enzymes; Glutathione; Heme Oxygenase (Decyclizing); Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Lipid Peroxidation; Male; Metallothionein; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species | 2008 |
Localization of septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of photoreceptor cell degeneration.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cobalt; DNA Fragmentation; Eosine Yellowish-(YS); GTP-Binding Proteins; Hematoxylin; Immunohistochemistry; Male; Mice; Photoreceptor Cells, Vertebrate; Rats; Rats, Wistar; Retina; Retinal Degeneration; Staining and Labeling; Time Factors; Tissue Distribution | 2007 |
Autocrine VEGF signaling is required for vascular homeostasis.
Topics: Animals; Apoptosis; Autocrine Communication; Blood Vessels; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Crosses, Genetic; Echocardiography; Endothelium, Vascular; Homeostasis; Mice; Mice, Mutant Strains; Mice, Transgenic; Models, Biological; Phosphorylation; RNA, Messenger; Signal Transduction; Telemetry; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Cobalt chloride induces apoptosis and zinc chloride suppresses cobalt-induced apoptosis by Bcl-2 expression in human submandibular gland HSG cells.
Topics: Antimutagenic Agents; Apoptosis; Blotting, Western; Cell Nucleus; Cell Survival; Cells, Cultured; Chlorides; Cobalt; Humans; Mouthwashes; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salivary Ducts; Submandibular Gland; Zinc Compounds | 2007 |
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
Topics: 3T3-L1 Cells; Active Transport, Cell Nucleus; Adipocytes; Adipokines; Amino Acids, Dicarboxylic; Androstadienes; Animals; Apelin; Carrier Proteins; Cell Hypoxia; Cell Line, Transformed; Cell Nucleus; Cobalt; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Intercellular Signaling Peptides and Proteins; Mice; Proto-Oncogene Proteins c-akt; Rotenone; Wortmannin | 2007 |
Anxiolytic-like effects induced by medial prefrontal cortex inhibition in rats submitted to the Vogel conflict test.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Anxiety; Avoidance Learning; Cobalt; Conflict, Psychological; Lidocaine; Limbic System; Male; Neural Inhibition; Neurotoxins; Pain Threshold; Prefrontal Cortex; Punishment; Rats; Rats, Inbred WKY; Statistics, Nonparametric | 2008 |
The paraventricular nucleus of hypothalamus mediates the pressor response to noradrenergic stimulation of the medial prefrontal cortex in unanesthetized rats.
Topics: Anesthetics, Local; Animals; Antimutagenic Agents; Blood Pressure; Cobalt; Drug Interactions; Lidocaine; Male; Neural Pathways; Norepinephrine; Paraventricular Hypothalamic Nucleus; Prefrontal Cortex; Rats; Rats, Wistar; Sympathomimetics; Vasopressins; Wakefulness | 2007 |
Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite.
Topics: Acute Kidney Injury; Animals; Cobalt; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Glomerular Filtration Rate; Heme Oxygenase (Decyclizing); Ischemia; Isoenzymes; Kidney Medulla; Male; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Sulfhydryl Compounds; Time Factors | 2007 |
[Hypoxia induced by CoCl2 influencing the expression and the activity of matrix metalloproteinase-2 in rat hepatic stellate cells].
Topics: Animals; Cell Hypoxia; Cell Line; Cobalt; Hepatic Stellate Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 2; Rats; RNA, Messenger | 2007 |
Ethylene is required for elicitin-induced oxidative burst but not for cell death induction in tobacco cell suspension cultures.
Topics: Algal Proteins; Aminooxyacetic Acid; Cell Death; Cells, Cultured; Cobalt; DNA Fragmentation; Dose-Response Relationship, Drug; Ethylenes; Hydrogen Peroxide; Nicotiana; Phytophthora; Respiratory Burst; Time Factors | 2007 |
The lateral septal area modulates the baroreflex in unanesthetized rats.
Topics: Analysis of Variance; Animals; Baroreflex; Blood Pressure; Cobalt; Heart Rate; Linear Models; Male; Microinjections; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Septal Nuclei; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Wakefulness | 2007 |
The biokinetics of inorganic cobalt in the human body.
Topics: Animals; Cobalt; Cobalt Radioisotopes; Humans; Models, Biological; Occupational Exposure; Species Specificity; Tissue Distribution | 2008 |
Intracellular Ca2+ stores are essential for injury induced Ca2+ signaling and re-endothelialization.
Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cobalt; Endothelial Cells; Gap Junctions; Humans; Receptors, Purinergic | 2008 |
The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development.
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Gene Silencing; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Transplantation; Oxygen; RNA, Messenger; RNA, Small Interfering; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2007 |
Human skin keloid fibroblasts display bioenergetics of cancer cells.
Topics: Adenosine Triphosphate; Adolescent; Adult; Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Child, Preschool; Cobalt; Deferoxamine; Digitonin; Energy Metabolism; Female; Fibroblasts; Glucose; Humans; Hydrogen Peroxide; Infant; Keloid; Lactic Acid; Male; Middle Aged; Oligomycins; Siderophores; Skin Neoplasms; Uncoupling Agents | 2008 |
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.
Topics: Animals; Antimutagenic Agents; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Blotting, Western; Chromatography, High Pressure Liquid; Cobalt; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Insulin-Like Growth Factor Binding Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; NADPH Oxidases; Obesity; Oxidative Stress; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; RNA, Messenger; Transforming Growth Factor beta | 2008 |
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.
Topics: Antigens, Surface; Cell Hypoxia; Cell Line, Tumor; Cobalt; ELAV Proteins; ELAV-Like Protein 1; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Polypyrimidine Tract-Binding Protein; Protein Binding; Protein Biosynthesis; Protein Transport; Ribosomes; RNA Interference; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 2008 |
Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a)).
Topics: Animals; Antidotes; Catalase; Cell Survival; Cell-Free System; Cobalt; Dose-Response Relationship, Drug; Environmental Pollutants; Hepatocytes; Hydrogen Sulfide; Hydroxocobalamin; In Vitro Techniques; Lethal Dose 50; Male; Mice; Oxidation-Reduction; Oxygen; Poisoning; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfides; Time Factors; Vitamin B Complex | 2007 |
Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription.
Topics: Alternative Splicing; Amino Acid Sequence; Binding Sites; Carcinoma, Renal Cell; Cell Differentiation; Cell Line, Tumor; Chromosomes, Human, Pair 16; Cobalt; Computational Biology; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Kidney Neoplasms; Molecular Sequence Data; Myoblasts; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; RNA, Messenger; Sequence Analysis, DNA; Time Factors; Transcription Factors; Transcription, Genetic; Up-Regulation | 2007 |
Hypoxia regulation of facilitated glucose transporter-1 and glucose transporter-3 in mouse chondrocytes mediated by HIF-1alpha.
Topics: Aggrecans; Animals; Cell Hypoxia; Cells, Cultured; Chondrocytes; Cobalt; Collagen Type II; Dose-Response Relationship, Drug; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred C57BL; Oxygen; RNA, Messenger | 2008 |
A reduction state potentiates the glucocorticoid response through receptor protein stabilization.
Topics: Cells, Cultured; Cobalt; Cytosol; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Humans; Hydrogen Peroxide; Oxidation-Reduction; Receptors, Glucocorticoid; Transfection | 2007 |
The neurohormone orexin stimulates hypoxia-inducible factor-1 activity.
Topics: Adenosine Triphosphate; Animals; Cell Culture Techniques; Cell Line; Chromatin Immunoprecipitation; Cobalt; Culture Media, Serum-Free; Genes, Reporter; Glucose; Humans; Hypothalamus; Hypoxia-Inducible Factor 1; Intracellular Signaling Peptides and Proteins; Kidney; Lactic Acid; Luciferases, Firefly; Mice; Mice, Knockout; Mitochondrial Proteins; Neuropeptides; Neurotransmitter Agents; Orexin Receptors; Orexins; Organ Culture Techniques; Plasmids; Proteins; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; Receptors, Neuropeptide; Transfection | 2007 |
The ventrolateral periaqueductal gray is involved in the cardiovascular response evoked by l-glutamate microinjection into the lateral hypothalamus of anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Cobalt; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Nerve Block; Periaqueductal Gray; Quinoxalines; Rats; Rats, Wistar | 2008 |
Reaction in the skin due to cobaltous chloride.
Topics: Cobalt; Humans; Skin | 1949 |
The effect of oral therapy with cobaltous chloride on the blood of patients suffering with chronic suppurative infection.
Topics: Chronic Disease; Cobalt; Communicable Diseases; Humans; Infections | 1949 |
Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide.
Topics: Acridines; Adrenergic beta-Agonists; Animals; Blotting, Western; Cattle; Cobalt; Enzyme Activation; Enzyme Induction; Guanylate Cyclase; Heme; Heme Oxygenase-1; Isoproterenol; Luminescence; Mesoporphyrins; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Organ Culture Techniques; Protoporphyrins; Pulmonary Artery; Spermine; Superoxides | 2008 |
Down-regulation of cobalt-induced HIF-1alpha expression correlates with cell proliferation and apoptosis in human gastric carcinoma cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Carcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cobalt; Down-Regulation; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Stomach Neoplasms | 2008 |
[Metal sensitivity in patients with joint replacement arthroplasties before and after surgery].
Topics: Adult; Aged; Cobalt; Cross-Sectional Studies; Dermatitis, Allergic Contact; Female; Follow-Up Studies; Germany; Hip Prosthesis; Humans; Hypersensitivity; Incidence; Knee Prosthesis; Male; Middle Aged; Nickel; Patch Tests; Postoperative Complications; Prosthesis Failure; Risk Factors; Surveys and Questionnaires | 2008 |
A retrospective study of 2585 patients patch tested with the European standard series in Hong Kong (1995-99).
Topics: Adult; Age Distribution; Allergens; Antimutagenic Agents; Balsams; Cobalt; Dermatitis, Allergic Contact; Female; Hong Kong; Humans; Irritants; Male; Nickel; Patch Tests; Perfume; Phenylenediamines; Retrospective Studies; Sex Distribution | 2008 |
Hypoxia modulates lipopolysaccharide induced TNF-alpha expression in murine macrophages.
Topics: Animals; Cell Hypoxia; Cell Line; Cobalt; Endotoxemia; Enzyme Activation; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Intracellular Signaling Peptides and Proteins; Kinetics; Lipopolysaccharides; Lung; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; RNA Stability; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension.
Topics: Amino Acids, Dicarboxylic; Base Sequence; Cells, Cultured; Cobalt; Deferoxamine; Dehydroepiandrosterone; DNA Primers; Enzyme Inhibitors; Estradiol; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Models, Cardiovascular; Myocytes, Smooth Muscle; Procollagen-Proline Dioxygenase; Pulmonary Artery; Testosterone | 2008 |
Elevated H(2)O (2) production via overexpression of a chloroplastic Cu/ZnSOD gene of lily (Lilium oriental hybrid 'Marco Polo') triggers ethylene synthesis in transgenic potato.
Topics: Amino Acid Oxidoreductases; Cobalt; Ethylenes; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glycine; Hydrogen Peroxide; Lilium; Microscopy, Electron, Scanning; Organophosphorus Compounds; Phenotype; Plant Proteins; Plant Stems; Plants, Genetically Modified; Silver Nitrate; Solanum tuberosum; Superoxide Dismutase | 2008 |
Medullary pathways mediating the parasubthalamic nucleus depressor response.
Topics: Animals; Atropine Derivatives; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Glutamic Acid; Heart Rate; Hexamethonium; Injections, Intravenous; Kidney; Male; Medulla Oblongata; Microinjections; Muscarinic Antagonists; Neural Inhibition; Neural Pathways; Nicotinic Antagonists; Rats; Rats, Wistar; Solitary Nucleus; Sympathetic Nervous System; Thalamic Nuclei | 2008 |
Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Down-Regulation; E2F6 Transcription Factor; Myocytes, Cardiac; Rats | 2008 |
Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells.
Topics: Angiogenesis Inhibitors; Cell Line, Tumor; Cobalt; Down-Regulation; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Melatonin; Vascular Endothelial Growth Factor A | 2008 |
Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer.
Topics: Cell Hypoxia; Cell Line, Tumor; Cobalt; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-8; Neovascularization, Pathologic; Neuropilin-2; Pancreatic Neoplasms; Up-Regulation; Vascular Endothelial Growth Factor A | 2008 |
[Inhibitory effect of genistein on hypoxia-inducible factor-1alpha expression induced by cobalt chloride in leukemia cell line K562].
Topics: Cobalt; Down-Regulation; Genistein; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; K562 Cells; RNA, Messenger | 2008 |
Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cobalt; Deferoxamine; Disease Models, Animal; Female; Hypoxia; Hypoxia-Ischemia, Brain; Male; Motor Skills; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Cobalt supplementation promotes hypoxic tolerance and facilitates acclimatization to hypobaric hypoxia in rat brain.
Topics: Acclimatization; Adaptation, Physiological; Altitude Sickness; Animals; Cobalt; Erythropoietin; Glucose Transporter Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Species Specificity; Vascular Endothelial Growth Factor A | 2008 |
Altered Stra13 and Dec2 circadian gene expression in hypoxic cells.
Topics: Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Bone Neoplasms; Cell Hypoxia; Circadian Rhythm; CLOCK Proteins; Cobalt; DNA-Binding Proteins; Fibroblasts; Gene Expression; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Hypoxia-Inducible Factor 1; Male; Mice; Mice, Inbred Strains; Nuclear Receptor Subfamily 1, Group D, Member 1; Osteosarcoma; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Trans-Activators; Transcription Factors; Transcriptional Activation | 2008 |
A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.
Topics: Animals; Antioxidants; Cell Differentiation; Chelating Agents; Cobalt; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Glutathione; Isoenzymes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Oxidants; Oxidation-Reduction; PC12 Cells; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfhydryl Compounds; Zinc | 2008 |
Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cobalt; Cycloheximide; Cysteine-Rich Protein 61; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kinetics; Leupeptins; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Proteins; Plasminogen Activator Inhibitor 1; Protein Biosynthesis; Protein Synthesis Inhibitors; Recombinant Proteins; RNA, Messenger; Stomach Neoplasms; Up-Regulation | 2008 |
A novel MRI marker for prostate brachytherapy.
Topics: Acrylates; Animals; Brachytherapy; Cobalt; Contrast Media; Dogs; Glass; Magnetic Resonance Imaging; Magnetics; Male; Nitrates; Phantoms, Imaging; Prostatic Neoplasms | 2008 |
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cobalt; Cytoplasm; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Immunohistochemistry; Iron-Regulatory Proteins; Liver Neoplasms; Protein Isoforms; Time Factors | 2008 |
Heterogeneity in binding and gene-expression regulation by HIF-2alpha.
Topics: Anaerobiosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cobalt; Erythropoietin; Gene Expression; Gene Expression Regulation; Humans; Oxygen; Promoter Regions, Genetic; Transcriptional Activation | 2008 |
Hypoxia enhances CXCR4 expression favoring microglia migration via HIF-1alpha activation.
Topics: Anaerobiosis; Animals; Cell Line; Cell Movement; Chemokine CXCL12; Cobalt; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Microglia; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, CXCR4; Transcription, Genetic | 2008 |
Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-alpha-mediated cell death.
Topics: Apoptosis; Blotting, Western; Cell Line; Cobalt; Deferoxamine; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microscopy, Fluorescence; Neuroprotective Agents; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
Effects of scutellarin on apoptosis induced by cobalt chloride in PC12 cells.
Topics: Animals; Apigenin; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Caspase Inhibitors; Cell Survival; Cobalt; Flow Cytometry; Glucuronates; Indicators and Reagents; Microscopy, Electron; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species | 2007 |
Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Carbachol; Cobalt; Female; Hypothalamic Area, Lateral; Medulla Oblongata; Neurons; Pain Measurement; Pain Threshold; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin Antagonists; Stilbamidines; Substance P; Time Factors | 2008 |
HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6.
Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Cobalt; Down-Regulation; Extracellular Space; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Lipopolysaccharides; MAP Kinase Kinase Kinase 5; Myeloid Cells; Toll-Like Receptor 4 | 2008 |
Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalis.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Blood Pressure; Calcium; Cobalt; Conflict, Psychological; Drinking; Fear; Male; Microinjections; Morphine; Rats; Rats, Sprague-Dawley; Reaction Time; Septal Nuclei; Stereotaxic Techniques; Synapses | 2008 |
Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis.
Topics: Antioxidants; Camellia sinensis; Catechin; Cell Hypoxia; Cells, Cultured; Cobalt; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Nasal Polyps; Neovascularization, Pathologic; Plant Extracts; Vascular Endothelial Growth Factor A | 2008 |
HIF and reactive oxygen species regulate oxidative phosphorylation in cancer.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carrier Proteins; Cobalt; Cytoskeletal Proteins; Deferoxamine; Glycolysis; Homeostasis; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Chaperones; Neoplasms; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation; Reactive Oxygen Species; Respiratory Burst; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells.
Topics: Antimutagenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Binding Sites; Carcinoma; Cell Line, Tumor; Cell Survival; Cobalt; Colorectal Neoplasms; Dose-Response Relationship, Drug; Down-Regulation; Feedback, Physiological; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Myeloid Cell Leukemia Sequence 1 Protein; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Ubiquitination | 2008 |
Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cobalt; Endodeoxyribonucleases; Female; Genetic Therapy; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2008 |
[Effect of HIF-1alpha on the proliferation and apoptosis of uterine cervix cancer SiHa cells].
Topics: Apoptosis; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Situ Nick-End Labeling; Plasmids; Transfection; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
[Effect of dominant negative HIF-1alpha (dn HIF-1alpha) on biological characteristics of uterine cervix cancer cells].
Topics: Apoptosis; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Situ Nick-End Labeling; Plasmids; Transfection; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3.
Topics: Activating Transcription Factor 1; Animals; Antioxidants; Cell Line; Cobalt; Hypoxia; Ion Channels; Mice; Mitochondria; Mitochondrial Proteins; Models, Biological; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; RNA, Small Interfering; Transcriptional Activation; Transfection; Uncoupling Protein 3 | 2008 |
CoCl2-induced expression of p300 promotes neuronal-like PC12 cell damage.
Topics: Animals; Antimutagenic Agents; Cobalt; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Nerve Degeneration; Oxidative Stress; p300-CBP Transcription Factors; PC12 Cells; Rats; RNA; RNA Interference | 2008 |
Protection of retinal cells from ischemia by a novel gap junction inhibitor.
Topics: Animals; Apoptosis; Cell Line; Cobalt; Gap Junctions; Ischemia; Mefloquine; Primaquine; Rats; Retina; Retinal Vessels | 2008 |
Purification and biochemical characterization of methionine aminopeptidase (MetAP) from Mycobacterium smegmatis mc2155.
Topics: Aminopeptidases; Calcium Chloride; Cobalt; Copper; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Ferrous Compounds; Hydrogen-Ion Concentration; Hydroxamic Acids; Leucine; Magnesium Chloride; Methionyl Aminopeptidases; Molecular Weight; Mycobacterium smegmatis; Peptides; Temperature | 2008 |
Estradiol protects PC12 cells against CoCl2-induced apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Cobalt; Cytochromes c; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Activation; Estradiol; Estrogens; Fas Ligand Protein; fas Receptor; Mitochondria; PC12 Cells; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
The paraventricular nucleus of the hypothalamus is involved in cardiovascular responses to acute restraint stress in rats.
Topics: Animals; Area Under Curve; Blood Pressure; Cardiovascular System; Cobalt; Heart Rate; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological; Stress, Psychological; Synapses | 2009 |
Cobalt chloride attenuates hypobaric hypoxia induced vascular leakage in rat brain: molecular mechanisms of action of cobalt chloride.
Topics: Animals; Brain; Brain Edema; Capillary Leak Syndrome; Capillary Permeability; Cobalt; Hypoxia, Brain; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2008 |
Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.
Topics: 20-Hydroxysteroid Dehydrogenases; Aged; Cadmium Compounds; Cell Cycle; Cells, Cultured; Cobalt; DNA Damage; Dose-Response Relationship, Drug; Epithelial Cells; Female; Gene Expression Regulation; Humans; Hydroxysteroid Dehydrogenases; Lead; Male; Middle Aged; Occupational Exposure; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Respiratory Mucosa; Steroids; Sulfates; Transcription Factors; Transcription, Genetic | 2008 |
First divalent metal complexes of the polyether ionophore Monensin A: X-Ray structures of [Co(Mon)2(H2O)2] and [Mn(Mon)2(H2O)2] and their bactericidal properties.
Topics: Anti-Bacterial Agents; Chlorides; Cobalt; Crystallography, X-Ray; Gram-Positive Bacteria; Hydrogen Bonding; Ionophores; Manganese Compounds; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Monensin; Spectrum Analysis; Water | 2008 |
[Molecular chaperone Hsp70 protects neuroblastoma SK-N-SH cells from hypoxic stress].
Topics: Cell Line, Tumor; Cobalt; HSP70 Heat-Shock Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Recombinant Proteins; Signal Transduction | 2008 |
Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.
Topics: Cell Line; Cobalt; Gene Expression Regulation; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Mutation; Oxygen; Procollagen-Proline Dioxygenase; Proteasome Endopeptidase Complex; RNA Interference; RNA, Small Interfering; Von Hippel-Lindau Tumor Suppressor Protein | 2008 |
Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine.
Topics: Antimutagenic Agents; Bacteria; Cell Line, Transformed; Cell Wall; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Oligodendroglia; Siderophores; Teichoic Acids; Time Factors; Toll-Like Receptors | 2008 |
Cellular mechanisms of cobalt-induced hippocampal epileptiform discharges.
Topics: Animals; Anticonvulsants; Antimutagenic Agents; Calcium Channels; Cobalt; Electroencephalography; Epilepsy; Gap Junctions; Hippocampus; Mice; Mice, Inbred C57BL; Pyramidal Cells; Receptors, GABA | 2009 |
Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Knockout; Purines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3 | 2008 |
Associations between baseline allergens and polysensitization.
Topics: Adult; Allergens; Cobalt; Denmark; Dermatitis, Allergic Contact; Disease Susceptibility; Female; Humans; Hypersensitivity, Immediate; Longitudinal Studies; Male; Methanol; Middle Aged; Myroxylon; Parabens; Patch Tests; Phenylenediamines; Potassium Dichromate; Probability; Risk Assessment; Sensitivity and Specificity; Sesquiterpenes | 2008 |
Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chloride.
Topics: Adaptation, Physiological; Anaerobiosis; Cobalt; Cryptococcus neoformans; Gene Expression Profiling; Gene Expression Regulation, Fungal; Metabolic Networks and Pathways; Microbial Viability; Mitochondria; Reactive Oxygen Species | 2008 |
CoCl(2) inhibits neural differentiation of retinoic acid-treated embryoid bodies.
Topics: Animals; Base Sequence; Cell Differentiation; Cell Proliferation; Cobalt; DNA Primers; Dose-Response Relationship, Drug; Embryonic Stem Cells; Immunohistochemistry; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin | 2008 |
Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells.
Topics: Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Invasiveness; Ovarian Neoplasms; Oxygen | 2008 |
Efficient production and partial characterization of aspartyl aminopeptidase from Aspergillus oryzae.
Topics: Aspergillus oryzae; Chromatography, Gel; Chromatography, Ion Exchange; Cobalt; Culture Media; Glutamyl Aminopeptidase; Molecular Weight; Recombinant Proteins; Substrate Specificity | 2008 |
Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Cobalt; Dioxanes; Heart Rate; Idazoxan; Male; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Restraint, Physical; Stress, Psychological; Synaptic Transmission; Thalamic Nuclei; Tropanes | 2009 |
Factors influencing the course and mechanism of grignard reactions; the preparation of substituted bibenzyls from grignard reagents, alkyl halides, and alkylbenzenes in the presence and absence of cobaltous chloride.
Topics: Bibenzyls; Cobalt; Indicators and Reagents | 1948 |
Expression of bystin in reactive astrocytes induced by ischemia/reperfusion and chemical hypoxia in vitro.
Topics: Animals; Animals, Newborn; Antimutagenic Agents; Astrocytes; Brain Ischemia; Cell Adhesion Molecules; Cell Shape; Cell Survival; Cells, Cultured; Cobalt; Glial Fibrillary Acidic Protein; Hypoxia; Mice; Reperfusion | 2008 |
Inhibition of advanced glycation end products (AGEs): an implicit goal in clinical medicine for the treatment of diabetic nephropathy?
Topics: Animals; Caloric Restriction; Cobalt; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Oxidative Stress; Rats; Treatment Outcome | 2008 |
Diagonal band of Broca modulates the cardiac component of the baroreflex in unanesthetized rats.
Topics: Animals; Baroreflex; Blood Pressure; Catheterization; Cobalt; Diagonal Band of Broca; Heart; Heart Rate; Male; Microinjections; Neural Inhibition; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Synaptic Transmission; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Hypoxia decreases insulin signaling pathways in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Transport; Blotting, Western; Cell Hypoxia; Cell Line; Cobalt; Glucose; Glycerol; Humans; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Interleukin-1beta; Interleukin-6; Lipolysis; Mice; Phosphorylation; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Receptor, Insulin; Signal Transduction | 2009 |
Evidence for circadian rhythms in human trophoblast cell line that persist in hypoxia.
Topics: Cell Line; Circadian Rhythm; Cobalt; DNA-Binding Proteins; Female; Gene Expression; Humans; Hypoxia; Nuclear Proteins; Oxygen; Period Circadian Proteins; Placenta; Placentation; Pregnancy; Transcription Factors; Trophoblasts; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2009 |
One- and two-electron reduced 1,2-diketone ligands in [Zn(II)(L*)2(Et2O)], [Co(II)(L*)2(Et2O)], and Na2(Et2O)4[Co(II)(LRed)2].
Topics: Chlorides; Cobalt; Crystallography, X-Ray; Glyoxal; Imines; Ketones; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Photometry; Spectrophotometry; Zinc Compounds | 2008 |
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.
Topics: Blotting, Northern; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Gene Expression Regulation, Enzymologic; Heme; Humans; Hydroxymethylbilane Synthase; Isoenzymes; Jurkat Cells; K562 Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Messenger; Tetrapyrroles; Uroporphyrinogen III Synthetase | 2008 |
Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Chromans; Cobalt; COS Cells; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Space; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hypoxia; Imidazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Time Factors | 2008 |
Inorganic photochemical protein scissors: photocleavage of lysozyme by Co(III) complexes.
Topics: Animals; Binding Sites; Chickens; Cobalt; Eggs; Kinetics; Models, Molecular; Muramidase; Photochemistry; Protein Conformation | 2008 |
Establishment of a cell-based assay to screen regulators of the hypoxia-inducible factor-1-dependent vascular endothelial growth factor promoter.
Topics: Cell Line; Cell Survival; Cobalt; DNA; Drug Evaluation, Preclinical; Drug Resistance; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Luciferases; Neomycin; Neovascularization, Physiologic; Plasmids; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Reproducibility of Results; Tetrazolium Salts; Thiazoles; Transfection; Vascular Endothelial Growth Factor A | 2008 |
[Effect of cobalt chloride on S100A4 expression in human gastric cancer cell BGC823].
Topics: Antimutagenic Agents; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cobalt; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Reverse Transcriptase Polymerase Chain Reaction; S100 Calcium-Binding Protein A4; S100 Proteins; Stomach Neoplasms | 2008 |
Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells.
Topics: Animals; Anthraquinones; Apoptosis; Cell Hypoxia; Cell Movement; Cells, Cultured; Cobalt; Electrophoretic Mobility Shift Assay; Female; Gene Expression; Glucose-6-Phosphatase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Monosaccharide Transport Proteins; Necrosis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Stromal Cells | 2009 |
Metallic haptens induce differential phenotype of human dendritic cells through activation of mitogen-activated protein kinase and NF-kappaB pathways.
Topics: Biomarkers; Cell Survival; Cells, Cultured; Cobalt; Cytokines; Dendritic Cells; Enzyme Activation; Haptens; Hematopoietic Stem Cells; Humans; NF-kappa B; Nickel; p38 Mitogen-Activated Protein Kinases; Potassium Dichromate; Signal Transduction | 2009 |
Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line.
Topics: Adenocarcinoma; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mucin-1; Promoter Regions, Genetic; RNA Stability; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic | 2009 |
HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo.
Topics: Animals; Brain; Brain Stem; Cobalt; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Extracellular Space; Gene Expression; Male; Motor Activity; Phenanthrolines; Potassium; Procollagen-Proline Dioxygenase; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tyrosine 3-Monooxygenase | 2009 |
All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway.
Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Caspase 3; Cobalt; Dose-Response Relationship, Drug; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Signal Transduction; Tretinoin | 2009 |
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.
Topics: Adenosine Triphosphate; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Calcium; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Flufenamic Acid; Gene Expression Regulation; Green Fluorescent Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mitochondria; Mutation; Neuroblastoma; Neurons; Protein Kinases; Rats; Threonine; Transfection; Tryptophan | 2009 |
The medial amygdaloid nucleus modulates cardiovascular responses to acute restraint in rats.
Topics: Amygdala; Animals; Blood Pressure; Cholinergic Agents; Cobalt; Drug Interactions; Heart Rate; Male; Rats; Rats, Wistar; Restraint, Physical | 2009 |
Determination of genotoxic effects of copper sulphate and cobalt chloride in Allium cepa root cells by chromosome aberration and comet assays.
Topics: Anaphase; Chromosome Aberrations; Cobalt; Comet Assay; Copper Sulfate; DNA Damage; Environmental Pollutants; Mitosis; Onions; Plant Roots; Telophase | 2009 |
Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma.
Topics: Active Transport, Cell Nucleus; Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Squamous Cell; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Epidermal Growth Factor; Female; Humans; Microscopy, Fluorescence; Models, Biological; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Tyrphostins; Uterine Cervical Neoplasms | 2009 |
N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats.
Topics: Anesthetics; Animals; Antihypertensive Agents; Autonomic Pathways; Baroreflex; Blood Pressure; Bradycardia; Cerebral Cortex; Cobalt; Efferent Pathways; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Isoquinolines; Neurons; Nitroprusside; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2009 |
Hypoxic preconditioning with cobalt attenuates hypobaric hypoxia-induced oxidative damage in rat lungs.
Topics: Animals; Antimutagenic Agents; Cobalt; Cytokines; Glutathione; Glutathione Disulfide; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemic Preconditioning; Lipid Peroxidation; Lung; Lung Injury; Male; Metallothionein; NF-E2-Related Factor 1; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2009 |
Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antimutagenic Agents; Cell Line; Cells, Cultured; Cobalt; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Fluoresceins; Humans; Indicators and Reagents; Membrane Potential, Mitochondrial; Mice; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Potassium; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2009 |
Degradation of atrazine by cobalt-mediated activation of peroxymonosulfate: Different cobalt counteranions in homogenous process and cobalt oxide catalysts in photolytic heterogeneous process.
Topics: Acetates; Atrazine; Catalysis; Cobalt; Hydrogen-Ion Concentration; Oxides; Peroxides; Photolysis; Titanium | 2009 |
Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells.
Topics: Animals; Antimutagenic Agents; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Count; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Drug Interactions; Edaravone; Free Radical Scavengers; Membrane Potential, Mitochondrial; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species | 2009 |
The diagonal band of Broca is involved in the pressor pathway activated by noradrenaline microinjected into the periaqueductal gray area of rats.
Topics: Animals; Biotin; Blood Pressure; Brain Mapping; Cobalt; Dextrans; Diagonal Band of Broca; Efferent Pathways; Heart Rate; Male; Microinjections; Norepinephrine; Periaqueductal Gray; Rats; Rats, Wistar; Synapses | 2009 |
Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array.
Topics: Alternative Splicing; Apoptosis; Cell Hypoxia; Cell Survival; Cobalt; Endothelium, Vascular; Exons; Gene Expression Profiling; Gene Expression Regulation; Heat-Shock Proteins; Humans; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Umbilical Veins | 2009 |
IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription.
Topics: 3T3-L1 Cells; Adiponectin; Animals; Cell Hypoxia; Cobalt; Fibroblasts; Genes, Reporter; Humans; Hypoglycemic Agents; Insulin Resistance; Insulin-Like Growth Factor Binding Protein 3; Mice; Obesity; PPAR gamma; Retinoid X Receptor alpha; Rosiglitazone; Thiazolidinediones; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2009 |
Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats.
Topics: Animals; Blood Pressure; Central Nervous System Agents; Cobalt; Corpus Callosum; Gyrus Cinguli; Heart Rate; Male; Microinjections; Prefrontal Cortex; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Synaptic Transmission; Tachycardia | 2009 |
IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.
Topics: Animals; Brain Ischemia; Cell Line; Cobalt; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Interleukins; Male; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Stroke; Up-Regulation | 2009 |
Antigenotoxic effects of Citrus aurentium L. fruit peel oil on mutagenicity of two alkylating agents and two metals in the Drosophila wing spot test.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Citrus; Cobalt; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Metals; Mutagenicity Tests; Mutation; Plant Oils; Potassium Dichromate; Wings, Animal | 2009 |
An NK1 receptor antagonist microinjected into the periaqueductal gray blocks lateral hypothalamic-induced antinociception in rats.
Topics: Animals; Behavior, Animal; Carbachol; Cholinergic Agonists; Cobalt; Female; Foot; Hypothalamic Area, Lateral; Microinjections; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Quinuclidines; Rats; Rats, Sprague-Dawley; Tail | 2009 |
Dipyridamole inhibits cobalt chloride-induced osteopontin expression in NRK52E cells.
Topics: Animals; Biocatalysis; Carbon Monoxide; Cell Line; Cobalt; Dipyridamole; Enzyme Induction; Epithelial Cells; Gene Expression Regulation; Heme; Heme Oxygenase-1; Kidney Tubules; Mitogen-Activated Protein Kinase Phosphatases; Osteopontin; Rats; Reactive Oxygen Species | 2009 |
CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells.
Topics: Apoptosis; Cardiolipins; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Gene Knockdown Techniques; Glioblastoma; Humans; Isoquinolines; Ligands; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidation-Reduction; Reactive Oxygen Species; Receptors, GABA; RNA, Small Interfering; Signal Transduction | 2009 |
The detection of pressure fluctuations, sonic audition, is the dominant mode of dipole-source detection in goldfish (Carassius auratus).
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Cobalt; Conditioning, Classical; Ear, Inner; Functional Laterality; Goldfish; Hearing; Loudness Perception; Pressure; Respiration; Signal Detection, Psychological | 2009 |
Alterations of histone modifications by cobalt compounds.
Topics: Acetylation; Cell Line, Tumor; Cobalt; Epigenesis, Genetic; Histones; Humans; Iron; Jumonji Domain-Containing Histone Demethylases; Methylation; Oligonucleotide Array Sequence Analysis; Oxidoreductases, N-Demethylating; Ubiquitination | 2009 |
Neuronal and glial alterations due to focal cortical hypoxia induced by direct cobalt chloride (CoCl2) brain injection.
Topics: Analysis of Variance; Animals; Antimutagenic Agents; Brain; Cell Death; Cobalt; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Lectins; Male; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Neuroglia; Neurons; Rats; Rats, Wistar; Staining and Labeling; Time Factors | 2009 |
Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells.
Topics: Actins; Analysis of Variance; Antifungal Agents; Cell Cycle; Cell Death; Cell Differentiation; Cell Line, Transformed; Cell Proliferation; Cell Survival; Ciclopirox; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Embryonic Stem Cells; Fetus; Humans; Hyperbaric Oxygenation; Hypoxia-Inducible Factor 1, alpha Subunit; Mesencephalon; Nerve Tissue Proteins; Pyridones; Siderophores | 2009 |
Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells.
Topics: ADAM Proteins; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cobalt; Glaucoma; Hypoxia; Muscarinic Agonists; Rats; Receptors, Muscarinic; Retinal Ganglion Cells; RNA, Messenger | 2009 |
Metal sensitivity to Elektra prostheses - two cases from a metal on metal implant for hand joint replacement.
Topics: Cobalt; Female; Hand Joints; Humans; Hypersensitivity; Joint Prosthesis; Middle Aged; Nickel; Patch Tests | 2009 |
Non-N-methyl-d-aspartate glutamate receptors in the lateral hypothalamus modulate cardiac baroreflex responses in conscious rats.
Topics: Animals; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Excitatory Amino Acid Antagonists; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tachycardia | 2009 |
Toxic effects of cobalt chloride on hematological factors of common carp (Cyprinus carpio).
Topics: Animals; Carps; Cobalt; Erythrocyte Count; Hematocrit; Hematologic Tests; Hemoglobins; Leukocyte Count | 2009 |
Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells.
Topics: Antimutagenic Agents; Cell Hypoxia; Cell Survival; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitor of Differentiation Protein 1; Inhibitor of Differentiation Protein 2; MAP Kinase Signaling System; Mitochondria; Neoplasm Metastasis; Neuroblastoma; Protein Transport; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis.
Topics: Active Transport, Cell Nucleus; Cell Line; Cell Nucleus; Cobalt; Cytosol; Electron Probe Microanalysis; Endoplasmic Reticulum; Golgi Apparatus; Homeostasis; Humans; Imaging, Three-Dimensional; Keratinocytes; Magnesium; Spectrometry, X-Ray Emission; Spectrophotometry, Atomic; Synchrotrons; Zinc | 2009 |
Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line.
Topics: Animals; Cell Line; Cell Survival; Cobalt; Culture Media; Environmental Exposure; Gills; Metal Nanoparticles; Oncorhynchus mykiss; Tungsten Compounds | 2009 |
Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.
Topics: Animals; Antimutagenic Agents; bcl-2-Associated X Protein; Blotting, Western; Cell Death; Cells, Cultured; Cobalt; Cyclophilins; Fluoresceins; In Situ Nick-End Labeling; Indicators and Reagents; Mice; Microscopy, Fluorescence; Mitochondrial ADP, ATP Translocases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Peptidyl-Prolyl Isomerase F; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2009 |
The heat shock protein 27 (Hsp27) operates predominantly by blocking the mitochondrial-independent/extrinsic pathway of cellular apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line; Cobalt; Cytoprotection; Gene Products, tat; HSP27 Heat-Shock Proteins; Humans; Hypoxia; Mitochondria, Heart; Myocardium; Recombinant Fusion Proteins; Staurosporine; Transduction, Genetic | 2009 |
Effects of lipoxin A(4) on CoCl(2)-induced angiogenesis and its possible mechanisms in human umbilical vein endothelial cells.
Topics: Angiogenesis Inhibitors; Cell Hypoxia; Cells, Cultured; Cobalt; Endothelial Cells; Endothelium, Vascular; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipoxins; Umbilical Veins; Vascular Endothelial Growth Factor A | 2009 |
Downregulation of gap junction expression and function by endoplasmic reticulum stress.
Topics: Animals; Cell Communication; Cell Line; Cobalt; Connexin 43; Down-Regulation; Endoplasmic Reticulum; Gap Junctions; Humans; Mice; Organ Specificity; Protein Processing, Post-Translational; Protein Transport; Rats; Stress, Physiological; Thenoyltrifluoroacetone | 2009 |
Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells.
Topics: Aminopeptidases; Antimutagenic Agents; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Down-Regulation; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Neovascularization, Pathologic | 2009 |
Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region.
Topics: Amino Acid Sequence; Cobalt; Crystallography; DNA Nucleotidylexotransferase; DNA Polymerase beta; DNA-Directed DNA Polymerase; Molecular Sequence Data; Mutation; Nucleotides; Point Mutation; Protein Conformation; Sequence Deletion; Templates, Genetic | 2009 |
Bone marrow derived stromal cells modified by adenovirus-mediated HIF-1alpha double mutant protect cardiac myocytes against CoCl2-induced apoptosis.
Topics: Adenoviridae; Animals; Apoptosis; Bone Marrow Cells; Cells, Cultured; Cobalt; Coculture Techniques; Gene Expression Regulation; Genetic Vectors; Hypoxia-Inducible Factor 1, alpha Subunit; Mutation; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Stromal Cells; Transforming Growth Factor beta1 | 2009 |
Engineered cobalt oxide nanoparticles readily enter cells.
Topics: Cell Line; Cell Line, Tumor; Cell Survival; Cells; Cobalt; Endothelial Cells; Hepatocytes; Humans; Magnetics; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nanoparticles; Oxides; Particle Size; Reactive Oxygen Species; Spectrometry, X-Ray Emission; Spectrophotometry, Atomic | 2009 |
[Hypoxia and its simulant CoCl(2) down-regulates Foxp3 expression independent from HIF-1alpha].
Topics: Cell Hypoxia; Cobalt; Down-Regulation; Forkhead Transcription Factors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Jurkat Cells; T-Lymphocytes, Regulatory; Transfection | 2009 |
Paraventricular nucleus mediates pressor response to noradrenaline injection into the dorsal periaqueductal gray area.
Topics: Animals; Antimutagenic Agents; Autonomic Pathways; Biotin; Blood Pressure; Cobalt; Dextrans; Male; Microinjections; Neural Pathways; Neuronal Tract-Tracers; Norepinephrine; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Presynaptic Terminals; Rats; Rats, Wistar; Reflex; Supraoptic Nucleus; Sympathetic Nervous System; Vasoconstriction | 2009 |
[Protective effects and its mechanism of lipoxins on human umbilical vein endothelial cells under hypoxia].
Topics: Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Colorimetry; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Lipoxins; Time Factors; von Willebrand Factor | 2009 |
In vitro effects of hypoxia-inducible factor 1alpha on the biological characteristics of the SiHa uterine cervix cancer cell line.
Topics: Antimutagenic Agents; Apoptosis; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cobalt; Female; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Vitro Techniques; Membrane Proteins; Mitochondrial Proteins; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A | 2009 |
Transcutaneous electrical nerve stimulation at both high and low frequencies activates ventrolateral periaqueductal grey to decrease mechanical hyperalgesia in arthritic rats.
Topics: Animals; Arthritis; Central Nervous System Agents; Cobalt; Inflammation; Knee Joint; Male; Microinjections; Pain; Pain Management; Pain Measurement; Pain Threshold; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Sprague-Dawley; Time Factors; Transcutaneous Electric Nerve Stimulation | 2009 |
Isolation of cobalt hyper-resistant mutants of Saccharomyces cerevisiae by in vivo evolutionary engineering approach.
Topics: Cell Survival; Cobalt; Directed Molecular Evolution; Drug Resistance, Fungal; Hot Temperature; Hydrogen Peroxide; Mutation; Nickel; Saccharomyces cerevisiae; Stress, Physiological | 2009 |
Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.
Topics: Bone Morphogenetic Protein 2; Brain Neoplasms; Cell Line, Tumor; Cobalt; Gene Silencing; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Oxygen; Procollagen-Proline Dioxygenase; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Tacrolimus Binding Proteins; TOR Serine-Threonine Kinases | 2009 |
Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1alpha.
Topics: Animals; Antimutagenic Agents; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; CHO Cells; Cobalt; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cricetinae; Cricetulus; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Promoter Regions, Genetic; Receptors, Virus | 2010 |
Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts.
Topics: 3T3 Cells; Animals; Cell Death; Cell Line, Transformed; Cobalt; Culture Media; DNA Damage; Fibroblasts; Inhibitory Concentration 50; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; Particle Size | 2009 |
Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma.
Topics: Animals; Aorta; Cobalt; Embryonic Stem Cells; Endothelium; Fibroblasts; Hypoxia; Melanoma, Experimental; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Receptors, Aryl Hydrocarbon; Recombination, Genetic; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2009 |
Sub-chronic oral toxicity study in Sprague-Dawley rats with hypoxia mimetic cobalt chloride towards the development of promising neutraceutical for oxygen deprivation.
Topics: Administration, Oral; Animals; Antimutagenic Agents; Body Weight; Cobalt; Dietary Supplements; Hypoxia; Ischemic Preconditioning; Lipid Peroxidation; Male; Organ Size; Rats; Rats, Sprague-Dawley | 2010 |
Hypoxia-inducible factor-1alpha suppresses the expression of macrophage scavenger receptor 1.
Topics: Animals; Antimutagenic Agents; Blotting, Western; Cell Hypoxia; Cell Line; Cobalt; Gene Expression; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Male; Mice; Mice, Inbred BALB C; Oxygen; Partial Pressure; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class A; Transfection | 2009 |
Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride.
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Glucosides; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Structure; Phenols; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2009 |
Cobalt chloride-induced hypoxia modulates the invasive potential and matrix metalloproteinases of primary and metastatic breast cancer cells.
Topics: Adenocarcinoma; Antimutagenic Agents; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cobalt; Collagen; Drug Combinations; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Laminin; Matrix Metalloproteinases; Neoplasm Invasiveness; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinases | 2009 |
T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium Channels, T-Type; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Cobalt; Gene Expression Regulation; Heart Ventricles; Membrane Potentials; Myocytes, Cardiac; Nickel; Oxidation-Reduction; Oxidative Stress; Patch-Clamp Techniques; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2009 |
Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.
Topics: Animals; Azoles; Catalase; Cattle; Cell Hypoxia; Chelating Agents; Cobalt; Copper; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Heme Oxygenase-1; Hydrogen Peroxide; Isoindoles; Mesoporphyrins; Organ Culture Techniques; Organoselenium Compounds; Potassium Chloride; Pulmonary Artery; Superoxide Dismutase; Superoxides; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents | 2009 |
Activating transcription factor 2 increases transactivation and protein stability of hypoxia-inducible factor 1alpha in hepatocytes.
Topics: Activating Transcription Factor 2; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Phosphorylation; Protein Binding; Protein Stability; Transcriptional Activation; Tumor Suppressor Protein p53 | 2009 |
Cobalt toxicity: chemical and radiological combined effects on HaCaT keratinocyte cell line.
Topics: Cell Line; Cell Survival; Clone Cells; Cobalt; Cobalt Radioisotopes; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Keratinocytes; Reactive Oxygen Species; Risk Assessment; Skin | 2010 |
Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes.
Topics: Caspase 3; Cell Respiration; Cobalt; Hep G2 Cells; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxygen Consumption; Toll-Like Receptors; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2009 |
Hydrogen sulphide protects H9c2 cells against chemical hypoxia-induced injury.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Cells, Cultured; Cobalt; Cytoprotection; Hydrogen Sulfide; Myocardium; Oxidative Stress; Rats; Reactive Oxygen Species | 2010 |
Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
Topics: Adenocarcinoma, Follicular; Anaerobiosis; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma; Carcinoma, Papillary; Cell Hypoxia; Cell Line, Tumor; Chromones; Cobalt; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins B-raf; PTEN Phosphohydrolase; RNA Interference; RNA, Small Interfering; Signal Transduction; Thyroid Neoplasms | 2010 |
Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cobalt; Down-Regulation; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Membrane Proteins; Mitochondrial Proteins; Muscarinic Agonists; Neurotoxins; Pilocarpine; Protein Transport; Proto-Oncogene Proteins; Rats; Receptors, Muscarinic; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction; Tumor Suppressor Protein p53 | 2010 |
Cobalt chloride induces hepatotoxicity in adult rats and their suckling pups.
Topics: Administration, Oral; Animals; Animals, Suckling; Antioxidants; Chemical and Drug Induced Liver Injury; Cobalt; Drinking; Environmental Pollutants; Female; Gestational Age; Liver Function Tests; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2011 |
Inhibition of oxygen-induced hypoxia-inducible factor-1alpha degradation unmasks estradiol induction of vascular endothelial growth factor expression in ECC-1 cancer cells in vitro.
Topics: Adrenomedullin; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cobalt; Cytoplasm; Endometrial Neoplasms; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Oxygen; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2009 |
Crystallization and heavy-atom derivatization of StHsp14.0, a small heat-shock protein from Sulfolobus tokodaii.
Topics: Bromides; Chlorides; Cobalt; Crystallization; Crystallography, X-Ray; Heat-Shock Proteins, Small; Manganese Compounds; Rubidium; Sodium Compounds; Strontium; Sulfolobus | 2009 |
Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
Topics: Adipocytes; Adipose Tissue; Antimutagenic Agents; Cells, Cultured; Cobalt; Female; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Oxygen; Symporters; Syndrome | 2010 |
Effect of heat stress on actin cytoskeleton and endoplasmic reticulum of tobacco BY-2 cultured cells and its inhibition by Co2+.
Topics: Actins; Animals; Cell Survival; Cells, Cultured; Cobalt; Cytoskeleton; Endoplasmic Reticulum; Hot Temperature; Nicotiana; Stress, Physiological | 2010 |
[Influence of cobalt chloride-induced hypoxia on the proliferation and apoptosis of periodontal ligament cells].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Periodontal Ligament; Up-Regulation | 2009 |
Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Cobalt; Colforsin; Deferoxamine; Disulfides; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indole Alkaloids; Male; Mice; Rats; Tumor Cells, Cultured | 2009 |
Catalytic synthesis of neutral hydrogen peroxide at a CoN2Cx cathode of a polymer electrolyte membrane fuel cell (PEMFC).
Topics: Carbon; Catalysis; Catalytic Domain; Cobalt; Electric Power Supplies; Electrochemistry; Electrodes; Electrolytes; Hot Temperature; Hydrogen Peroxide; Ligands; Membranes, Artificial; Nitrogen; Oxidation-Reduction; Oxygen; Polymers | 2010 |
Hypoxia affected SDF-1alpha-CXCR4 interaction between bone marrow stem cells and osteoblasts via osteoclast modulation.
Topics: 3T3 Cells; Animals; Base Sequence; Cathepsin K; Cell Communication; Cell Differentiation; Cell Hypoxia; Cell Line; Chemokine CXCL12; Cobalt; DNA Primers; Female; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Receptors, CXCR4; RNA, Messenger; Up-Regulation | 2010 |
Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Gene Expression Profiling; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Macrophages; Mice; Oxidative Stress; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Toll-Like Receptor 4; Up-Regulation | 2010 |
Influence of metal ions on the interaction between gatifloxacin and calf thymus DNA.
Topics: Cadmium Chloride; Cobalt; Copper; DNA; Fluoroquinolones; Gatifloxacin; Indicators and Reagents; Magnesium Chloride; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2010 |
Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.
Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line; Cobalt; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Epithelial Cells; Esophageal Neoplasms; Gene Expression Profiling; Humans; Hydroxyprostaglandin Dehydrogenases; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Interleukin-1beta; Intramolecular Oxidoreductases; Neoplasm Proteins; Oxygen; Prostaglandin-E Synthases; Recombinant Fusion Proteins; RNA Interference; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Tumor Cells, Cultured | 2010 |
Geniposide inhibits CoCl2-induced PC12 cells death via the mitochondrial pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cobalt; Glucagon-Like Peptide-1 Receptor; Iridoids; Mitochondria; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, Glucagon; Signal Transduction | 2009 |
Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes.
Topics: Carbohydrate Metabolism; Cell Hypoxia; Cell Line; Cluster Analysis; Cobalt; Gene Expression Profiling; Humans; Hypoxia-Inducible Factor 1; Keratinocytes; Nanoparticles; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Signal Transduction; Tungsten Compounds | 2010 |
Nitric oxide donors or nitrite counteract copper-[dithiocarbamate](2)-mediated tumor cell death and inducible nitric oxide synthase down-regulation: possible role of a nitrosyl-copper [dithiocarbamate](2) complex.
Topics: Cell Death; Cell Line, Tumor; Cell Survival; Cobalt; Cyclic N-Oxides; Down-Regulation; Free Radical Scavengers; Humans; Imidazoles; Melanoma; Mitochondria; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitrites; Nitroprusside; Nitroso Compounds; Organometallic Compounds; Poly(ADP-ribose) Polymerases; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite | 2010 |
The first intestinal motility patterns in fetal mice are not mediated by neurons or interstitial cells of Cajal.
Topics: Animals; Calcium Channels, L-Type; Cobalt; Colon; Duodenum; Female; Fetus; Gastrointestinal Motility; Interstitial Cells of Cajal; Male; Mice; Mice, Mutant Strains; Muscle Contraction; Myenteric Plexus; Neurons; Nicardipine; Proto-Oncogene Proteins c-kit; Tetrodotoxin | 2010 |
Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model.
Topics: Animals; Base Sequence; Bone Development; Bone Marrow Cells; Cells, Cultured; Cobalt; DNA Primers; Immunohistochemistry; Male; Mice; Mice, SCID; Models, Animal; Periosteum; Stromal Cells; Tissue Engineering | 2010 |
Asymmetric hydrovinylation of unactivated linear 1,3-dienes.
Topics: Alkadienes; Catalysis; Cobalt; Phosphines; Vinyl Compounds | 2010 |
Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation.
Topics: Analysis of Variance; Animals; Blotting, Western; Cattle; Cell Proliferation; Cells, Cultured; Cobalt; Corpus Luteum; Dose-Response Relationship, Drug; Endothelin-2; Female; Gene Expression Regulation; Gene Silencing; Gonadotropin-Releasing Hormone; Granulosa Cells; Hypoxia; Luteinizing Hormone; Ovarian Follicle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Time Factors; Vascular Endothelial Growth Factor A | 2010 |
The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores.
Topics: Arthritis, Rheumatoid; Atherosclerosis; Cell Differentiation; Cell Hypoxia; Cloning, Molecular; Cobalt; Growth Differentiation Factor 15; Humans; Immunization; Lipopolysaccharides; Macrophages; Neoplasms; Protein Processing, Post-Translational; Secretory Pathway; Transforming Growth Factor beta; Transgenes; Tretinoin; U937 Cells | 2010 |
Involvement of the lateral septal area in the expression of fear conditioning to context.
Topics: Animals; Behavior, Animal; Blood Pressure; Cobalt; Conditioning, Classical; Electroshock; Fear; Freezing Reaction, Cataleptic; Heart Rate; Male; Microinjections; Rats; Rats, Wistar; Septum of Brain; Time Factors | 2010 |
Nickel, manganese, cobalt, and iron-catalyzed deprotonative arene dimerization.
Topics: Catalysis; Chlorides; Cobalt; Dimerization; Ferric Compounds; Manganese Compounds; Molecular Structure; Nickel; Protons; Stereoisomerism; Triazoles | 2010 |
Cardiac delta-aminolevulinic acid synthetase activity. Effects of fasting, cobaltous chloride and hemin.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Fasting; Guinea Pigs; Heart; Heme; Kinetics; Male; Mice; Myocardium; Rabbits; Rats; Rats, Sprague-Dawley | 1980 |
Hepatic mitochondrial cholesterol hydroxylase activity--a cytochrome P-450-catalyzed mono-oxygenation refractory to cobaltous chloride.
Topics: Animals; Catalysis; Cholesterol; Cobalt; Cytochrome P-450 Enzyme System; Male; Mitochondria, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley | 1980 |
Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability.
Topics: Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cobalt; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; DNA Adducts; DNA Damage; Gene Expression Regulation, Neoplastic; Histones; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Inactivation, Metabolic; Lung Neoplasms; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2010 |
miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.
Topics: Binding Sites; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MicroRNAs; Promoter Regions, Genetic; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Time Factors; Transfection; Vascular Endothelial Growth Factor A | 2010 |
Cobalt polycythemia relative effects of oral and subcutaneous administration of cobaltous chloride.
Topics: Cobalt; Humans; Polycythemia | 1947 |
Effect of vitamin B12 pulse addition on the performance of cobalt deprived anaerobic granular sludge bioreactors.
Topics: Biodegradation, Environmental; Biomass; Bioreactors; Cobalt; Methane; Methanol; Micronutrients; Sewage; Trace Elements; Vitamin B 12; Water Pollutants, Chemical; Water Purification | 2010 |
Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells.
Topics: Animals; Apoptosis; Blotting, Western; Cobalt; Drugs, Chinese Herbal; Membrane Potentials; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species | 2010 |
The insular cortex modulates cardiovascular responses to acute restraint stress in rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiovascular System; Cerebral Cortex; Cobalt; Heart Rate; Male; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological | 2010 |
Subcellular distribution of S100A4 and its transcriptional regulation under hypoxic conditions in gastric cancer cell line BGC823.
Topics: Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Response Elements; S100 Calcium-Binding Protein A4; S100 Proteins; Stomach Neoplasms; Transcription, Genetic | 2010 |
[Effects of salidroside on tubular epithelial to myofibroblast transition under cobaltous chloride induced hypoxic status].
Topics: Animals; Cell Differentiation; Cell Hypoxia; Cell Line; Cobalt; Epithelial Cells; Glucosides; Kidney Tubules; Myofibroblasts; Phenols; Rats; Rhodiola | 2010 |
[Expression of receptor activator of nuclear factor kappaB ligand and osteoprotegerin of mice osteoblast induced by metal ions].
Topics: Animals; Cell Line; Chlorides; Chromium Compounds; Cobalt; Ions; Metals; Mice; Osteoblasts; Osteoprotegerin; RANK Ligand | 2010 |
Hypoxia induces the PDZ domain-containing syntenin in the marine teleost Paralichthys olivaceus.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cobalt; Flatfishes; Hypoxia; Molecular Sequence Data; PDZ Domains; Syntenins | 2010 |
Vibratory sources as compound stimuli for the octavolateralis systems: dissection of specific stimulation channels using multiple behavioral approaches.
Topics: Acoustic Stimulation; Animals; Antimutagenic Agents; Behavior, Animal; Cobalt; Conditioning, Classical; Ear, Inner; Fishes; Lateral Line System; Orientation; Probability; Respiration; ROC Curve; Signal Detection, Psychological; Vibration | 2010 |
Hypoxia preconditioning by cobalt chloride enhances endurance performance and protects skeletal muscles from exercise-induced oxidative damage in rats.
Topics: Animals; Antioxidants; Cell Hypoxia; Cobalt; Creatine Kinase, MM Form; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Heme Oxygenase (Decyclizing); Lactic Acid; Lipid Peroxidation; Lipofuscin; Male; Metallothionein; Mitochondria, Muscle; Mitochondrial Proteins; Muscle, Skeletal; Muscular Diseases; Necrosis; Oxidative Stress; Physical Endurance; Physical Exertion; Rats; Rats, Wistar; Reactive Oxygen Species | 2010 |
Apparent PKA activity responds to intermittent hypoxia in bone cells: a redox pathway?
Topics: 3T3 Cells; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Biosensing Techniques; Cattle; Cell Hypoxia; Cobalt; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelial Cells; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Glucose; Imines; Mice; Microfluidics; Osteoblasts; Oxidation-Reduction; Oxygen; Phosphoprotein Phosphatases; Phosphorylation; Pyrans; Reactive Oxygen Species; Spectrometry, Fluorescence; Spiro Compounds; Stress, Mechanical; Time Factors; Transfection | 2010 |
N-methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats.
Topics: Adrenergic beta-Antagonists; Animals; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Isoquinolines; Male; Microinjections; Parasympathetic Nervous System; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Induction of invasion in an organotypic oral cancer model by CoCl2, a hypoxia mimetic.
Topics: Antigens, CD; Carcinoma, Squamous Cell; Cell Culture Techniques; Cells, Cultured; Cobalt; Collagen; Collagen Type IV; Culture Media; Cyclooxygenase 2; Fibroblasts; Humans; Hypoxia; Keratins; Laminin; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Nerve Tissue Proteins; Proto-Oncogene Proteins c-met; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Tongue Neoplasms; Young Adult | 2010 |
Inhibition of the PI3K-Akt pathway suppresses sFlt1 expression in human placental hypoxia models in vitro.
Topics: Cell Line, Tumor; Cell Survival; Chromones; Cobalt; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2010 |
Effect of hypoxic stress-activated Polo-like kinase 3 on corneal epithelial wound healing.
Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Cobalt; Electrophoresis, Polyacrylamide Gel; Epithelium, Corneal; Humans; Hydrogen Peroxide; Hypoxia; Immunohistochemistry; Mice; Mice, Knockout; Microscopy, Confocal; Organ Culture Techniques; Oxidative Stress; Protein Serine-Threonine Kinases; Wound Healing | 2010 |
Transitions towards either slow-oxidative or fast-glycolytic phenotype can be induced in the murine WTt myogenic cell line.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Line; Cobalt; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Myosin Heavy Chains; Oxidation-Reduction; Phenotype; PPAR delta; Protein Isoforms | 2010 |
Cobalt chloride stimulates phosphoinositide 3-kinase/Akt signaling through the epidermal growth factor receptor in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cobalt; DNA, Neoplasm; ErbB Receptors; Humans; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; S Phase; Signal Transduction | 2010 |
Acute reversible inactivation of the bed nucleus of stria terminalis induces antidepressant-like effect in the rat forced swimming test.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Cobalt; Depression; Exploratory Behavior; Male; Microinjections; Rats; Rats, Wistar; Septal Nuclei; Swimming | 2010 |
Ginsenoside Rb1 protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening.
Topics: Androstadienes; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cardiotonic Agents; Caspase 3; Cell Hypoxia; Cells, Cultured; Cobalt; Cytochromes c; Flow Cytometry; Ginsenosides; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Protein Kinase Inhibitors; Random Allocation; Rats; Wortmannin | 2010 |
Oxidative stress-induced attenuation of thrombospondin-1 expression in primary rat astrocytes.
Topics: Acetylcysteine; Animals; Astrocytes; Cells, Cultured; Cobalt; Extracellular Signal-Regulated MAP Kinases; Fluorescent Antibody Technique; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Reactive Oxygen Species; RNA, Messenger; Thrombospondin 1 | 2011 |
Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX.
Topics: Antigens, Neoplasm; Antimutagenic Agents; Blotting, Western; Breast Neoplasms; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma in Situ; Carcinoma, Ductal, Breast; Cell Hypoxia; Cell Line, Tumor; Cobalt; Female; Gene Expression; Glucose Transporter Type 1; Humans; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Phenotype; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Positive concomitant test reactions to allergens in the standard patch test series.
Topics: Adult; Allergens; Balsams; Cobalt; Cross Reactions; Dermatitis, Allergic Contact; Female; Formaldehyde; Humans; Male; Methenamine; Middle Aged; Nickel; Patch Tests; Perfume; Potassium Dichromate; Resins, Plant; Urea | 2010 |
Variability in patch test reactions--first report from the Norwegian Patch Test Registry.
Topics: Adult; Allergens; Benzothiazoles; Cobalt; Dermatitis, Allergic Contact; Formaldehyde; Humans; Male; Middle Aged; Multicenter Studies as Topic; Norway; Parabens; Patch Tests; Phenylenediamines; Potassium Dichromate; Prevalence; Registries; Sulfhydryl Compounds | 2010 |
Nail-art and cobalt allergy.
Topics: Adult; Cobalt; Cosmetics; Dermatitis, Allergic Contact; Female; Humans; Nails | 2010 |
Anisotropy characterization of I-125 seed with attached encapsulated cobalt chloride complex contrast agent markers for MRI-based prostate brachytherapy.
Topics: Anisotropy; Brachytherapy; Cobalt; Contrast Media; Humans; Image Enhancement; Iodine Radioisotopes; Magnetic Resonance Imaging; Male; Phantoms, Imaging; Prostatic Neoplasms; Radiopharmaceuticals | 2011 |
Protective effects of polyphenolic compounds on oxidative stress-induced cytotoxicity in PC12 cells.
Topics: Animals; Antioxidants; Catechin; Cell Survival; Cobalt; Flavonoids; Gallic Acid; Glutathione; Hydrogen Peroxide; Nitric Oxide; Oxidative Stress; PC12 Cells; Phenols; Polyphenols; Protective Agents; Rats; Reactive Oxygen Species | 2010 |
Lutein protects RGC-5 cells against hypoxia and oxidative stress.
Topics: Animals; Antimutagenic Agents; Cell Hypoxia; Cell Line; Cobalt; Hydrogen Peroxide; Lutein; Oxidants; Oxidative Stress; Rats | 2010 |
The effect of hypoxia mimetic cobalt chloride on the expression of EC-SOD in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Antioxidants; Cell Hypoxia; Chromans; Cobalt; Dose-Response Relationship, Drug; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mice; Reactive Oxygen Species; Superoxide Dismutase; Transcription Factors; Tumor Necrosis Factor-alpha | 2010 |
Paraventricular nucleus modulates autonomic and neuroendocrine responses to acute restraint stress in rats.
Topics: Animals; Autonomic Pathways; Blood Pressure; Cobalt; Corticosterone; Corticotropin-Releasing Hormone; Heart Rate; Male; Neurotoxins; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Synaptic Transmission | 2010 |
Acute reversible inactivation of the ventral medial prefrontal cortex induces antidepressant-like effects in rats.
Topics: Animals; Antidepressive Agents; Cobalt; Depression; Disease Models, Animal; Male; Microinjections; Motor Activity; Prefrontal Cortex; Rats; Rats, Wistar; Swimming; Synaptic Transmission | 2010 |
Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Chorionic Gonadotropin; Cobalt; Copulation; Corpus Luteum; Female; Granulosa Cells; Green Fluorescent Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Luteinization; Mice; Mice, Inbred C57BL; Ovarian Follicle; Oxygen; RNA, Messenger | 2010 |
Alleviation of salt stress-induced inhibition of seed germination in cucumber (Cucumis sativus L.) by ethylene and glutamate.
Topics: Amino Acids, Cyclic; Cobalt; Cucumis sativus; Ethylenes; Germination; Glutamic Acid; Glycine; Organophosphorus Compounds; Sodium Chloride | 2010 |
[Effect of Cobaltous chloride on the transcription activity of modified human eNOS promoter].
Topics: Cobalt; Endothelial Cells; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide Synthase Type III; Promoter Regions, Genetic; Transcription, Genetic | 2010 |
Patch test reactivity to metal allergens following regulatory interventions: a 33-year retrospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Child; Child, Preschool; Cobalt; Denmark; Dermatitis, Allergic Contact; Environmental Exposure; Female; Humans; Male; Middle Aged; Nickel; Patch Tests; Potassium Dichromate; Retrospective Studies; Young Adult | 2010 |
Functional changes in murine mammary cancer cells elicited by CoCl2-induced hypoxia.
Topics: Animals; Cell Movement; Cell Proliferation; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2010 |
The induction of tuftelin expression in PC12 cell line during hypoxia and NGF-induced differentiation.
Topics: Adrenal Glands; Animals; Cell Differentiation; Cobalt; Dental Enamel Proteins; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Nerve Growth Factor; Oxygen; Oxygen Consumption; PC12 Cells; Rats; Receptor, trkA; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2011 |
Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles.
Topics: Animals; Calcium Channel Blockers; Calcium Signaling; Cell Membrane; Cobalt; Depsipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Female; Locusta migratoria; Lower Gastrointestinal Tract; Muscle Contraction; Muscle, Smooth; Mycotoxins; Nifedipine; Oviducts; Trifluoperazine; Verapamil | 2010 |
Functional role of gangliotetraosylceramide in epithelial-to-mesenchymal transition process induced by hypoxia and by TGF-{beta}.
Topics: Animals; Blotting, Western; Cell Hypoxia; Cell Movement; Cells, Cultured; Cobalt; Epithelial-Mesenchymal Transition; G(M2) Ganglioside; Gangliosides; Immunoprecipitation; Mammary Glands, Animal; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta | 2010 |
Long term in vitro biostability of segmented polyisobutylene-based thermoplastic polyurethanes.
Topics: Biocompatible Materials; Cobalt; Materials Testing; Microscopy, Electron, Scanning; Oxidation-Reduction; Polyenes; Polymers; Polyurethanes; Spectroscopy, Fourier Transform Infrared; Tensile Strength | 2010 |
Inducers of chemical hypoxia act in a gender- and brain region-specific manner on primary astrocyte viability and cytochrome C oxidase.
Topics: Animals; Apoptosis; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Cell Culture Techniques; Cell Survival; Cerebral Cortex; Cobalt; Cyclooxygenase Inhibitors; Electron Transport Complex IV; Female; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Mesencephalon; Mice; Mice, Inbred BALB C; Necrosis; Potassium Cyanide; Reactive Oxygen Species; Sex Characteristics; Sodium Azide | 2011 |
Nanosegregated composites of an imidazolium salt and a layered inorganic compound: organization of both anions and cations in interlayer space.
Topics: Ammonia; Cobalt; Crystallization; Hydroxides; Imidazoles; Microscopy, Electron, Scanning; Molecular Conformation; Nanocomposites; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction | 2010 |
VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells.
Topics: Animals; Brefeldin A; Cell Line; Cobalt; Free Radicals; Hypoxia; Mast Cells; Mice; Mice, Mutant Strains; Proto-Oncogene Proteins c-fyn; R-SNARE Proteins; Tetanus Toxin; Vascular Endothelial Growth Factor A | 2010 |
Protective effects of 20-hydroxyecdysone on CoCl(2)-induced cell injury in PC12 cells.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Cobalt; Cytochromes c; Ecdysterone; Enzyme Activation; Flow Cytometry; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; PC12 Cells; Rats; Reactive Oxygen Species | 2010 |
Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
Topics: Amino Acids, Dicarboxylic; Angiotensin II; Animals; Carbonic Anhydrase IX; Carbonic Anhydrases; Cobalt; Enzyme Induction; Glucose Transporter Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Kidney Failure, Chronic; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar | 2010 |
Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear.
Topics: Animals; Anxiety Disorders; Association Learning; Cobalt; Fear; Male; Models, Animal; Neurotoxins; Prefrontal Cortex; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli.
Topics: Adult; Aged; Animals; Antimutagenic Agents; Body Weight; Cells, Cultured; Cobalt; Humans; Hypoxia; Male; Mice; Mice, Knockout; Middle Aged; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myostatin; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Wistar; Recombinant Proteins; Signal Transduction; SKP Cullin F-Box Protein Ligases; Up-Regulation | 2011 |
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage.
Topics: Animals; Blotting, Western; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cobalt; Genes, Reporter; I-kappa B Proteins; In Situ Nick-End Labeling; Neuroprotective Agents; NF-kappa B; Peroxiredoxin VI; Rats; Reactive Oxygen Species; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Spatial and temporal expression of hypoxia-inducible factor-1α during myogenesis in vivo and in vitro.
Topics: Animals; Cell Differentiation; Cell Line; Cell Nucleus; Cobalt; Gene Expression Regulation, Developmental; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Muscle Development; Muscle Fibers, Skeletal; MyoD Protein; Myogenin; Protein Stability; Protein Transport; Regeneration; RNA, Messenger; Time Factors | 2011 |
Divergent effect of cobalt and beryllium salts on the fate of peripheral blood monocytes and T lymphocytes.
Topics: Beryllium; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Humans; Interferon-gamma; Interleukin-1beta; Monocytes; NF-kappa B; RNA Interference; Signal Transduction; T-Lymphocytes; Tumor Suppressor Protein p53 | 2011 |
Heme oxygenase is involved in cobalt chloride-induced lateral root development in tomato.
Topics: Ascorbic Acid; Blotting, Western; Cobalt; Heme Oxygenase (Decyclizing); Plant Proteins; Plant Roots; Reverse Transcriptase Polymerase Chain Reaction; Seedlings; Solanum lycopersicum | 2011 |
Mechanism of pharmacodynamic action of cobalt chloride.
Topics: Cobalt; Humans | 1945 |
The action of cobalt chloride on the cardiovascular, respiratory and intestinal systems.
Topics: Cobalt; Humans | 1945 |
Hypoxic preconditioning facilitates acclimatization to hypobaric hypoxia in rat heart.
Topics: Acclimatization; Animals; Cardiotonic Agents; Cobalt; DNA-Binding Proteins; Erythropoietin; Heart; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Metallothionein; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Heat shock protein 90 mediates cytoprotection by H₂S against chemical hypoxia-induced injury in PC12 cells.
Topics: Animals; Antioxidants; Apoptosis; Cell Hypoxia; Cobalt; Cytoprotection; Cytotoxins; Down-Regulation; Drug Evaluation, Preclinical; HSP90 Heat-Shock Proteins; Hydrogen Sulfide; Hypoxia; Membrane Potential, Mitochondrial; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species | 2011 |
Inhibition of contractions of nerve processes in calcium-free medium.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Movement; Cobalt; Isotonic Solutions; Lymnaea; Neurites; Nimodipine; Nitrendipine; Ringer's Solution | 2010 |
Recovery of motor spontaneous activity after intranasal delivery of human recombinant erythropoietin in a focal brain hypoxia model induced by CoCl2 in rats.
Topics: Administration, Intranasal; Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cobalt; Disease Models, Animal; Erythropoietin; Exploratory Behavior; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Erythropoietin; Recombinant Proteins; Recovery of Function; Reticulocytes; Rotarod Performance Test | 2011 |
DNA microarray analysis of the liver of mice treated with cobalt chloride.
Topics: Animals; Cobalt; DNA, Complementary; Gene Expression; Gene Expression Profiling; Liver; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis; RNA; RNA, Complementary; Toxicity Tests | 2010 |
IGF and GH mRNA levels are suppressed upon exposure to micromolar concentrations of cobalt and zinc in rainbow trout white muscle.
Topics: Animals; Cobalt; Gene Expression; Growth Hormone; Muscle, Skeletal; Oncorhynchus mykiss; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatomedins; Water Pollutants, Chemical; Zinc Sulfate | 2011 |
[Effect of CoCl2 pretreatment on Na + and K+ currents of the rat hippocampal neurons after acute hypoxia].
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cobalt; Hippocampus; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Sodium Channels | 2003 |
Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride.
Topics: Cobalt; Ergosterol; Fusarium; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trichothecenes | 2011 |
Prelimbic but not infralimbic cortex is involved in the pressor response to chemoreflex activation in awake rats.
Topics: Animals; Blood Pressure; Bradycardia; Cardiovascular System; Chemoreceptor Cells; Cobalt; Heart Rate; Male; Potassium Cyanide; Prefrontal Cortex; Rats; Rats, Wistar; Reflex; Respiration; Synaptic Transmission; Wakefulness | 2011 |
Combined effects of TNF-α, IL-1β, and HIF-1α on MMP-2 production in ACL fibroblasts under mechanical stretch: an in vitro study.
Topics: Adult; Anterior Cruciate Ligament; Cells, Cultured; Cobalt; Drug Synergism; Fibroblasts; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 2; Middle Aged; NF-kappa B; Nitriles; Stress, Mechanical; Sulfones; Tumor Necrosis Factor-alpha; Young Adult | 2011 |
Vitamin C is dispensable for oxygen sensing in vivo.
Topics: Amino Acid Substitution; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cell Hypoxia; Cell Line; Cobalt; Glutathione; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; L-Gulonolactone Oxidase; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Mutant Proteins; Oxygen; Procollagen-Proline Dioxygenase | 2011 |
Chemical-garden formation, morphology, and composition. II. Chemical gardens in microgravity.
Topics: Calcium Chloride; Cations; Chlorides; Cobalt; Manganese Compounds; Microscopy, Electron, Scanning; Nickel; Silicates; Spectrometry, X-Ray Emission; Weightlessness | 2011 |
Hypoxia-inducible factor 1α regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Topics: Animals; ATPase Inhibitory Protein; Blotting, Western; Cell Line; Cells, Cultured; Cobalt; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Male; Mitochondrial Proteins; Oligonucleotides, Antisense; Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sepsis | 2011 |
Allergic palmoplantar pustulosis caused by cobalt in cast dental crowns: a case report.
Topics: Cobalt; Crowns; Dental Alloys; Dental Restoration, Permanent; Dermatitis, Allergic Contact; Device Removal; Humans; Hypersensitivity; Lymphocyte Activation; Male; Middle Aged; Patch Tests; Psoriasis | 2011 |
Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.
Topics: Animals; Base Sequence; Breast; Cell Hypoxia; Cell Line, Tumor; Chromatin Immunoprecipitation; Cobalt; DEAD-box RNA Helicases; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Molecular Sequence Data; Protein Binding; Protein Stability; Protein Transport; Response Elements; Xenograft Model Antitumor Assays | 2011 |
BDNF regulates GLAST and glutamine synthetase in mouse retinal Müller cells.
Topics: Animals; Annexins; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Hypoxia; Mice; Retina; Time Factors | 2012 |
Hypoxia and a hypoxia mimetic up-regulate matrix metalloproteinase 2 and 9 in equine laminar keratinocytes.
Topics: Animals; Biomimetics; Cell Hypoxia; Cells, Cultured; Cobalt; Foot Diseases; Hoof and Claw; Horse Diseases; Horses; Hypoxia; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Up-Regulation | 2011 |
Hypothalamic supraoptic but not paraventricular nucleus is involved in cardiovascular responses to carbachol microinjected into the bed nucleus of stria terminalis of unanesthetized rats.
Topics: Animals; Carbachol; Cholinergic Agonists; Cobalt; Functional Laterality; Hypothalamus, Anterior; Male; Microinjections; Neural Pathways; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Septal Nuclei; Vasopressins; Wakefulness | 2011 |
Honokiol inhibits hypoxia-inducible factor-1 pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cobalt; Enzyme-Linked Immunosorbent Assay; Female; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Lignans; Luciferases; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms | 2011 |
Delayed myocardial preconditioning induced by cobalt chloride in the rat: HIF-1α and iNOS involvement.
Topics: Animals; Cadmium; Cardiotonic Agents; Cobalt; Guanidines; Heart; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning, Myocardial; Male; Myocardium; Nitric Oxide Synthase Type II; Procollagen-Proline Dioxygenase; Rats; Rats, Wistar; Reperfusion Injury; Transcription Factors | 2012 |
Dermatologic manifestations of musicians: a case report and review of skin conditions in musicians.
Topics: Cobalt; Dermatitis, Allergic Contact; Humans; Male; Music; Nickel; Palladium; Young Adult | 2011 |
Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Culture Techniques; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cobalt; Drug Evaluation, Preclinical; Glucosides; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Neuroprotective Agents; NF-kappa B; Phenols; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species | 2011 |
Effects of 635nm light-emitting diode irradiation on angiogenesis in CoCl(2) -exposed HUVECs.
Topics: Analysis of Variance; Blotting, Western; Cell Survival; Cells, Cultured; Cobalt; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Lasers, Semiconductor; Neovascularization, Physiologic; Oxidative Stress; Phosphorylation; Radiation Dosage; Reactive Oxygen Species; Signal Transduction; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Wound Healing | 2011 |
Decreased Cyr61 under hypoxia induces extravillous trophoblasts apoptosis and preeclampsia.
Topics: Adult; Apoptosis; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; Cysteine-Rich Protein 61; Down-Regulation; Female; Humans; Pre-Eclampsia; Pregnancy; Trophoblasts | 2011 |
Propolis attenuates cobalt induced-nephrotoxicity in adult rats and their progeny.
Topics: Animals; Animals, Newborn; Antioxidants; Biomarkers; Cobalt; Environmental Pollutants; Female; Kidney; Kidney Diseases; Kidney Function Tests; Lipid Peroxidation; Milk; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Propolis; Rats; Rats, Wistar | 2012 |
Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia-induced injury in H9c2 cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Benzoquinones; Blotting, Western; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Cytoprotection; HSP90 Heat-Shock Proteins; Hydrogen Sulfide; Lactams, Macrocyclic; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Up-Regulation | 2011 |
Oxidative stress mediates chemical hypoxia-induced injury and inflammation by activating NF-κb-COX-2 pathway in HaCaT cells.
Topics: Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Inflammation; Interleukin-6; Interleukin-8; Keratinocytes; NF-kappa B; Nitrobenzenes; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Skin; Sulfonamides | 2011 |
Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cell Line; Cobalt; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Rats; RNA Interference; RNA, Small Interfering; Transcription Factors | 2011 |
Stabilization of hypoxia-inducible factor-1α in buffer containing cobalt chloride for Western blot analysis.
Topics: Animals; Blotting, Western; Cobalt; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Rats; Rats, Wistar; Structure-Activity Relationship | 2011 |
Molecular characterization and transcriptional analysis of the olive flounder (Paralichthys olivaceus) YGHL1 gene in response to hypoxia and infection.
Topics: Amino Acid Sequence; Anaerobiosis; Animals; Base Sequence; Cell Line; Cobalt; Edwardsiella tarda; Enterobacteriaceae Infections; Fish Diseases; Flounder; Gene Expression; Hypoxia-Inducible Factor 1; Molecular Sequence Data; Oxygen; Phylogeny; Polymorphism, Single Nucleotide | 2011 |
The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status.
Topics: Apoptosis; Cell Line, Tumor; Cobalt; Gene Knockdown Techniques; Genes, p53; Humans; Mutation; Neuroblastoma; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53 | 2011 |
Movements of Rana catesbeiana tadpoles in weak current flows resemble a directed random walk.
Topics: Animals; Cobalt; Immunohistochemistry; Larva; Orientation; Rana catesbeiana; Rheology; Swimming; Walking; Water Movements | 2011 |
Contribution of hypoxia-inducible factor-1α to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells.
Topics: Animals; Blotting, Western; Cattle; Cell Hypoxia; Cobalt; Deferoxamine; Female; Ferrous Compounds; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Luteal Cells; Oligodeoxyribonucleotides; Quaternary Ammonium Compounds; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2011 |
Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Cobalt; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen Sulfide; Hypoxia; Interleukin-1beta; Interleukin-6; Interleukin-8; NF-kappa B; Nitrobenzenes; Proline; Reactive Oxygen Species; Signal Transduction; Sulfonamides; Thiocarbamates | 2011 |
Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.
Topics: Animals; Auditory Threshold; Blotting, Western; Cell Survival; Cobalt; Cochlea; Environmental Exposure; Enzyme Inhibitors; Evoked Potentials, Auditory; Guanylate Cyclase; Hair Cells, Auditory; Hearing; Hearing Loss, Noise-Induced; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Mice, Inbred BALB C; Noise | 2011 |
Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc protein expression after hypoxic stress.
Topics: 3' Untranslated Regions; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cobalt; ELAV Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mouth Neoplasms; Proto-Oncogene Proteins c-myc; Stress, Physiological | 2011 |
Effect of hypoxia mimetic cobalt chloride on the expression of extracellular-superoxide dismutase in retinal pericytes.
Topics: Acetylcysteine; Animals; Apoptosis; Butyric Acid; Caspase 3; Cobalt; Diabetic Retinopathy; DNA Fragmentation; Down-Regulation; Free Radical Scavengers; Hypoxia; Pericytes; Rats; Reactive Oxygen Species; Retina; Superoxide Dismutase | 2011 |
Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor.
Topics: Amino Acids, Dicarboxylic; Angiotensin II; Animals; Aorta; Blood Pressure; Blotting, Northern; Blotting, Western; Cell Hypoxia; Cells, Cultured; Cobalt; Down-Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Procollagen-Proline Dioxygenase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2011 |
Hypoxia-mimetic agents inhibit proliferation and alter the morphology of human umbilical cord-derived mesenchymal stem cells.
Topics: Aza Compounds; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cobalt; Flow Cytometry; Humans; Mesenchymal Stem Cells; Umbilical Cord | 2011 |
Single-layer graphene oxide sheet: a novel substrate for dip-pen nanolithography.
Topics: Cobalt; Graphite; Microscopy, Atomic Force; Nanotechnology; Nanotubes, Carbon; Oxides; Silicon Dioxide | 2011 |
Behavioral and autonomic responses to acute restraint stress are segregated within the lateral septal area of rats.
Topics: Animals; Antimutagenic Agents; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Body Temperature; Cardiovascular Physiological Phenomena; Cardiovascular System; Cobalt; Heart Rate; Male; Maze Learning; Microinjections; Rats; Rats, Wistar; Restraint, Physical; Septum of Brain; Stress, Psychological; Synaptic Transmission | 2011 |
Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner.
Topics: Animals; Blotting, Western; Cobalt; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Gene Expression Regulation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1; Indican; Indoles; Kidney Failure, Chronic; Luciferases; Oxygen; Rats; Uremia | 2011 |
Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.
Topics: Alkaline Phosphatase; Animals; Apoptosis; Aspirin; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cellular Microenvironment; Cobalt; Cyclooxygenase 2; Deferoxamine; Female; Fractures, Bone; Humans; Indomethacin; Mice; Osteoblasts; Poly(ADP-ribose) Polymerases; Sodium Salicylate; Sulindac | 2012 |
Occupational allergic contact dermatitis of the ears caused by thiurams in a headset.
Topics: Adrenal Cortex Hormones; Allergens; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Occupational; Disulfiram; Ear Diseases; Female; Fungicides, Industrial; Humans; Middle Aged; Nickel; Perfume; Thiram | 2011 |
Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (Müller) cells.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cobalt; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Eye Proteins; Guinea Pigs; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Nerve Growth Factors; Neuroglia; Rats; Retina; RNA, Messenger; RNA, Small Interfering; Serpins; Up-Regulation; Vascular Endothelial Growth Factor A | 2012 |
[Lead adsorption and arsenite oxidation by cobalt doped birnessite].
Topics: Adsorption; Arsenic; Arsenites; Cobalt; Environmental Pollution; Lead; Manganese Compounds; Microspheres; Nanoparticles; Oxidation-Reduction; Oxides | 2011 |
Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro.
Topics: Animals; Apoptosis; Brain Infarction; Caspase 3; Cells, Cultured; Cerebral Cortex; Cobalt; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; Neurons; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
Topics: Amino Acids, Dicarboxylic; Animals; Cell Hypoxia; Cell Line; Cobalt; Dextrans; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Mice; Mice, Inbred C57BL; Nuclear Proteins; Occludin; Oxidants; Oxidation-Reduction; Oxidative Stress; Permeability; Peroxiredoxins; Primary Cell Culture; Procollagen-Proline Dioxygenase; Respiratory Mucosa; RNA Interference; Trachea | 2011 |
L-Proline/CoCl2-catalyzed highly diastereo- and enantioselective direct aldol reactions.
Topics: Alcohols; Aldehydes; Catalysis; Cobalt; Ketones; Proline; Stereoisomerism | 2011 |
Differential response to CoCl2-stimulated hypoxia on HIF-1α, VEGF, and MMP-2 expression in ligament cells.
Topics: Adult; Anterior Cruciate Ligament; Cell Hypoxia; Cell Movement; Cells, Cultured; Cobalt; Fibroblasts; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 2; Medial Collateral Ligament, Knee; Middle Aged; Vascular Endothelial Growth Factor A; Wound Healing; Young Adult | 2012 |
Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway.
Topics: Animals; Blotting, Western; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Nicotinamide Phosphoribosyltransferase; PC12 Cells; Rats; Real-Time Polymerase Chain Reaction; Serine Proteinase Inhibitors; Sincalide | 2011 |
Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Radiation Tolerance; RNA, Small Interfering; Transfection | 2011 |
Adipokine expression in brown and white adipocytes in response to hypoxia.
Topics: Adipocytes, White; Adipokines; Adipose Tissue, Brown; Animals; Antimutagenic Agents; Cells, Cultured; Cobalt; Deferoxamine; Hypoxia; Immunoblotting; Leptin; Mice; Siderophores | 2012 |
Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts.
Topics: Amino Acids, Dicarboxylic; Antimutagenic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Cobalt; Cyclin-Dependent Kinase Inhibitor p27; Deferoxamine; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Interleukin-1; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Ki-67 Antigen; Mimosine; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Procollagen-Proline Dioxygenase; Protein Kinase Inhibitors; Proteins; Siderophores; Vascular Endothelial Growth Factor A | 2012 |
Role of the lateral line mechanosensory system in directionality of goldfish auditory evoked escape response.
Topics: Animals; Biomechanical Phenomena; Cobalt; Escape Reaction; Evoked Potentials, Auditory; Goldfish; Lateral Line System; Mechanotransduction, Cellular; Models, Biological; Orientation; Reaction Time; Vision, Ocular | 2011 |
Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility.
Topics: Alkenes; Amines; Animals; Biocompatible Materials; Calorimetry, Differential Scanning; Cell Line; Cobalt; Cross-Linking Reagents; Foreign-Body Reaction; Gold; Hernia; Hydrogen Peroxide; Materials Testing; Metal Nanoparticles; Mice; Microscopy, Electron, Scanning; Nanotechnology; Polypropylenes; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Surface Properties; Surgical Mesh | 2011 |
Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells.
Topics: Animals; Apoptosis; Cell Hypoxia; Cobalt; Enzyme Inhibitors; Imidazoles; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Pyridines; Rats; Reactive Oxygen Species | 2012 |
Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Cell Hypoxia; Cobalt; Cystathionine beta-Synthase; Down-Regulation; Enzyme Activation; Hydrogen Sulfide; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species; Up-Regulation | 2011 |
Role of reactive oxygen species in the neural and hormonal regulation of the PNMT gene in PC12 cells.
Topics: Animals; Cell Hypoxia; Cholinergic Neurons; Cobalt; Dexamethasone; Epinephrine; Gene Expression Regulation; Neurons; Nitric Oxide; Oxidative Stress; PC12 Cells; Phenylethanolamine N-Methyltransferase; Promoter Regions, Genetic; Rats; Reactive Oxygen Species; Transfection | 2011 |
RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.
Topics: Adenoma; Animals; Cell Line, Tumor; Cobalt; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Pathologic; Pituitary Neoplasms; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2012 |
Effects of serum cobalt ion concentration on the liver, kidney and heart in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Diseases; Hepatocytes; Joint Prosthesis; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred ICR; Microscopy, Electron; Myocytes, Cardiac | 2010 |
ADAM17 regulates TNFα production by placental trophoblasts.
Topics: ADAM Proteins; ADAM17 Protein; Adult; Caspase 3; Cobalt; Dipeptides; Female; Heme Oxygenase-1; Humans; Hypoxia; Oxidative Stress; Placenta; Pre-Eclampsia; Pregnancy; RNA, Small Interfering; Trophoblasts; Tumor Necrosis Factor-alpha | 2011 |
The effect of ascorbic acid on the distribution of soluble Cr and Co ions in the blood and organs of rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Chlorides; Chromium; Chromium Compounds; Cobalt; Drug Interactions; Humans; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2013 |
Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level.
Topics: Animals; Antigens, Differentiation; Antimutagenic Agents; Calcium; Cell Differentiation; Cells, Cultured; Cobalt; Embryonic Stem Cells; Homeostasis; Humans; Mice; Myocardium; Organ Specificity | 2011 |
Image analysis of colocalization of nuclear DNA and GFP labelled HIF-1α in stable transformants.
Topics: Anthraquinones; Cell Nucleus; Cobalt; DNA; Fluorescence; Fluorescent Dyes; Green Fluorescent Proteins; HEK293 Cells; High-Throughput Screening Assays; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Image Processing, Computer-Assisted; Microscopy, Confocal | 2012 |
Oxygen as a regulator of MA-10 cell functions: effect of cobalt chloride on vascular endothelial growth factor production.
Topics: Animals; Base Sequence; Cell Line; Cobalt; DNA Primers; Enzyme-Linked Immunosorbent Assay; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2012 |
Cobalt (II) chloride promoted formation of honeycomb patterned cellulose acetate films.
Topics: Cellulose; Cobalt; Humidity; Nanostructures; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction | 2012 |
Analytical constraints for the analysis of human cell line secretomes by shotgun proteomics.
Topics: Antimutagenic Agents; Bronchi; Cell Line; Cobalt; Culture Media, Conditioned; Epithelial Cells; Humans; Mass Spectrometry; Proteome; Proteomics; Respiratory Mucosa | 2012 |
Preparation and characterization of cobalt-substituted anthrax lethal factor.
Topics: Antigens, Bacterial; Bacillus megaterium; Bacterial Toxins; Catalytic Domain; Cell Culture Techniques; Cobalt; Kinetics; Metalloendopeptidases; Spectrophotometry; Zinc | 2011 |
Vascular endothelial growth factor receptor 2 (VEGFR2, Flk-1/KDR) protects HEK293 cells against CoCl(2) -induced hypoxic toxicity.
Topics: Apoptosis; Cobalt; HEK293 Cells; Humans; Hypoxia; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
[Protective effects and mechanism of hyperin on CoCl2-induced PC12 cells].
Topics: Animals; Apoptosis; Cell Survival; Cells; Cobalt; Hypericum; PC12 Cells; Plant Extracts; Protective Agents; Quercetin; Rats | 2011 |
[Effect of hypoxia on the proliferation and hypoxia inducible factor-1α expression in human leukemia HL-60 cells].
Topics: Cell Hypoxia; Cell Proliferation; Cobalt; HL-60 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; RNA, Messenger | 2011 |
Hypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1α and inhibits stromal cell-derived factor-1 in human endometrial stromal cells.
Topics: Adult; Cell Hypoxia; Cell Survival; Cells, Cultured; Chemokine CXCL12; Cobalt; Echinomycin; Endometrium; Female; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetics; Middle Aged; Neovascularization, Physiologic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Vascular Endothelial Growth Factor A | 2012 |
Inhibition of ROS-activated ERK1/2 pathway contributes to the protection of H2S against chemical hypoxia-induced injury in H9c2 cells.
Topics: Animals; Apoptosis; Butadienes; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; Hydrogen Sulfide; Membrane Potential, Mitochondrial; Nitriles; Oxidative Stress; Rats; Reactive Oxygen Species | 2012 |
NADPH oxidase in plasma membrane is involved in stomatal closure induced by dehydroascorbate.
Topics: Calcium Channel Blockers; Calcium Channels; Catalase; Cell Membrane; Cobalt; Dehydroascorbic Acid; Dithiothreitol; Flavonoids; Hydrogen Peroxide; Imidazoles; NADPH Oxidases; Nicotiana; Onium Compounds; Plant Proteins; Plant Stomata | 2012 |
Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspase 7; Cell Survival; Cells, Cultured; Cobalt; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung; Nickel; Oxidative Stress; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species | 2012 |
Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades.
Topics: Adenocarcinoma; Adrenomedullin; Biomarkers, Tumor; Case-Control Studies; Catechin; Cell Line, Tumor; Cobalt; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Grading; Resveratrol; RNA, Messenger; Stilbenes; Up-Regulation; Vascular Endothelial Growth Factor A | 2012 |
Vasohibin-1 and retinal pigment epithelium.
Topics: Animals; Antimutagenic Agents; Cell Cycle Proteins; Cell Line; Choroidal Neovascularization; Cobalt; DNA, Complementary; Gene Expression; Genetic Therapy; Humans; Hypoxia; Rats; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A | 2012 |
Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia.
Topics: Animals; Antibodies; Bone Resorption; Cell Differentiation; Cell Hypoxia; Cobalt; Femoral Artery; Growth Differentiation Factor 15; Ligation; Mice; Mice, Inbred C57BL; NF-kappa B; Osteoclasts; Osteocytes; RANK Ligand; Signal Transduction; Solubility; Up-Regulation | 2012 |
Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation.
Topics: Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Cardiovascular System; Cobalt; Heart Rate; Hemodynamics; Immunohistochemistry; Male; Potassium Chloride; Potassium Cyanide; Rats; Rats, Wistar; Reflex; Septal Nuclei; Stimulation, Chemical | 2012 |
An AD-related neuroprotector rescues transformed rat retinal ganglion cells from CoCl₂-induced apoptosis.
Topics: Alzheimer Disease; Animals; Antimutagenic Agents; Apoptosis; Cell Line, Transformed; Cobalt; Intracellular Signaling Peptides and Proteins; Neuroprotective Agents; Rats; Retinal Ganglion Cells | 2012 |
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; HT29 Cells; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazines; Pyridazines; Pyrroles; Thiones; Thiophenes | 2012 |
Apelin supports primary rat retinal Müller cells under chemical hypoxia and glucose deprivation.
Topics: Animals; Apelin Receptors; Apoptosis; Cell Hypoxia; Cell Movement; Cell Survival; Cobalt; Cytoprotection; Gene Expression Regulation; Glucose; Intercellular Signaling Peptides and Proteins; Neuroglia; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Retina; RNA, Messenger; Transcription, Genetic | 2012 |
Occupational hand dermatitis among cement workers in Taiwan.
Topics: Adult; Aged; Cobalt; Construction Materials; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Hand Dermatoses; Humans; Male; Middle Aged; Potassium Dichromate; Taiwan | 2011 |
Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1α pathway.
Topics: Apoptosis; Benzoates; Bridged-Ring Compounds; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Monoterpenes; Nitric Oxide; Paeonia; Plant Roots; Proto-Oncogene Proteins; Tumor Suppressor Protein p53 | 2012 |
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Choroid; Cobalt; Endothelial Cells; Immunoblotting; Models, Biological; Sirtuin 1; Transcription Factor RelA; Vascular Endothelial Growth Factor A | 2012 |
Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells.
Topics: Aryl Hydrocarbon Hydroxylases; Cell Hypoxia; Cells, Cultured; Cobalt; Cytochrome P-450 CYP3A; Down-Regulation; Gene Expression Regulation, Enzymologic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Promoter Regions, Genetic; Protein Stability; RNA, Messenger; Time Factors; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A | 2012 |
Protective effect of zinc chloride against cobalt chloride-induced cytotoxicity on vero cells: preliminary results.
Topics: Animals; Antimutagenic Agents; Chlorides; Chlorocebus aethiops; Cobalt; Cytotoxins; Dose-Response Relationship, Drug; Mouthwashes; Vero Cells; Zinc Compounds | 2012 |
In vitro effect of unacylated ghrelin and obestatin on human luteal cell function.
Topics: Acylation; Adult; Cells, Cultured; Cobalt; Dinoprost; Enzyme-Linked Immunosorbent Assay; Female; Ghrelin; Humans; Luteal Cells; Progesterone; Real-Time Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A | 2012 |
Largemouth bass (Micropterus salmoides) switch feeding modalities in response to sensory deprivation.
Topics: Animals; Bass; Cobalt; Feeding Behavior; Lateral Line System; Predatory Behavior; Sensory Deprivation; Visual Perception | 2012 |
UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Gene Expression; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ion Channels; Lung Neoplasms; Mitochondrial Proteins; Oxygen; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Uncoupling Protein 2 | 2012 |
Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Cell Line, Tumor; Cell Nucleus; Cobalt; Cytoplasm; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Liver Neoplasms; Luciferases; Molecular Sequence Data; Promoter Regions, Genetic; Protein Multimerization; Transfection; Vascular Endothelial Growth Factor A | 2012 |
[Differential proteomic analysis in human umbilical cord mesenchymal stem cells induced by cobalt chloride].
Topics: Cobalt; Humans; Mesenchymal Stem Cells; Proteome; Proteomics; Umbilical Cord | 2011 |
Activation of hypoxia-inducible factor by cobalt is associated with the attenuation of tissue injury and apoptosis in cyclosporine-induced nephropathy.
Topics: Animals; Apoptosis; Cell Line; Cobalt; Cyclosporine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunosuppressive Agents; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley | 2012 |
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.
Topics: Animals; Blood Pressure; Cobalt; Cyclooxygenase 2; Heme Oxygenase-1; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Male; Natriuresis; Rats; Rats, Inbred Dahl; Transcriptional Activation | 2012 |
Effect of water hardness on the toxicity of cobalt and nickel to a freshwater fish, Capoeta fusca.
Topics: Animals; Calcium Carbonate; Cobalt; Cyprinidae; Environmental Monitoring; Fresh Water; Iran; Lethal Dose 50; Nickel; Toxicity Tests, Acute; Water Pollutants, Chemical | 2011 |
A simple and rapid quantitative sweat test based on cobalt chloride color change.
Topics: Administration, Cutaneous; Austria; Bicycling; Cobalt; Colorimetry; Coloring Agents; Exercise; Humans; Predictive Value of Tests; Sensitivity and Specificity; Sweat; Sweating; Time Factors; Transdermal Patch | 2012 |
Hypoxia-induced up-regulation of aquaporin-1 protein in prostate cancer cells in a p38-dependent manner.
Topics: Aquaporin 1; Calcium; Cell Hypoxia; Cell Line, Tumor; Cobalt; Humans; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Transcription, Genetic; Up-Regulation | 2012 |
PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress.
Topics: Animals; Cell Hypoxia; Cell Line; Chromones; Cobalt; Gene Knockdown Techniques; Hypoxia-Inducible Factor 1, alpha Subunit; Isothiocyanates; Macrophages; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Stress, Physiological; Sulfoxides; Thiocyanates; Toll-Like Receptor 4; Transcription, Genetic; Up-Regulation | 2012 |
Contact allergy to metals in adolescents: nickel release from metal accessories 7 years after the implementation of the EU Nickel Directive in Poland.
Topics: Adolescent; Cobalt; Dermatitis, Allergic Contact; European Union; Female; Humans; Legislation as Topic; Male; Nickel; Palladium; Patch Tests; Poland; Potassium Dichromate; Prevalence; Surveys and Questionnaires | 2012 |
Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1α pathway.
Topics: Antimutagenic Agents; Apoptosis; Autophagy; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-1beta; Matrix Metalloproteinase 8; Membrane Potential, Mitochondrial; Membrane Proteins; Microtubule-Associated Proteins; Periodontal Ligament; Proto-Oncogene Proteins; Signal Transduction; Up-Regulation | 2012 |
Formation and evolution of chemical gradients and potential differences across self-assembling inorganic membranes.
Topics: Chemistry, Inorganic; Cobalt; Electrochemistry; Hydrogen-Ion Concentration; Membranes; Silicon Dioxide | 2012 |
Post-translational regulated and hypoxia-responsible VEGF plasmid for efficient secretion.
Topics: Animals; Cell Line; Cells, Cultured; Cobalt; DNA, Complementary; Exenatide; Furin; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Peptides; Plasmids; Protein Processing, Post-Translational; Protein Sorting Signals; Protein Structure, Tertiary; Rats; Transfection; Vascular Endothelial Growth Factor A; Venoms | 2012 |
Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells.
Topics: Antimutagenic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Pancreatic Neoplasms; RNA, Messenger; Up-Regulation | 2012 |
HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Cobalt; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; RNA Interference; RNA, Small Interfering; Transcription, Genetic; Xeroderma Pigmentosum Group A Protein | 2012 |
Hypoxia-inducible factor 1-α-AA-modified bone marrow stem cells protect PC12 cells from hypoxia-induced apoptosis, partially through VEGF/PI3K/Akt/FoxO1 pathway.
Topics: Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Hypoxia; Cerebral Infarction; Cobalt; Coculture Techniques; Forkhead Transcription Factors; Green Fluorescent Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lentivirus; Male; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Rats; Rats, Sprague-Dawley; Signal Transduction; Stem Cells; Survivin; Transfection; Vascular Endothelial Growth Factor A | 2012 |
Effects of cobalt chloride on nitric oxide and cytokines/chemokines production in microglia.
Topics: Animals; Blotting, Western; Cell Culture Techniques; Cell Line; Cell Survival; Chemokines; Cobalt; Cytokines; Dose-Response Relationship, Drug; Flow Cytometry; Interleukin-6; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Hepatic and adipocyte cells respond differentially to iron overload, hypoxic and inflammatory challenge.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Antimicrobial Cationic Peptides; Cell Hypoxia; Cobalt; GTP Phosphohydrolases; Hep G2 Cells; Hepatocytes; Hepcidins; Humans; Interleukin-6; Iron; Mice; Mitochondrial Proteins; NF-kappa B; Tumor Necrosis Factor-alpha | 2012 |
Na+/H+ exchanger 1 inhibition contributes to K562 leukaemic cell differentiation.
Topics: Cation Transport Proteins; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Hypoxia; Cobalt; Guanidines; Humans; Hydrogen-Ion Concentration; Interleukin-8; K562 Cells; Leukemia; p38 Mitogen-Activated Protein Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones; Up-Regulation | 2012 |
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Topics: Animals; Antihypertensive Agents; Case-Control Studies; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cobalt; Cyclin B1; Disease Models, Animal; Dynamins; Enzyme Activation; Familial Primary Pulmonary Hypertension; Genetic Therapy; Glycolysis; GTP Phosphohydrolases; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubule-Associated Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitosis; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Quinazolinones; Rats; Rats, Sprague-Dawley; RNA Interference; Serine; Time Factors; Transfection | 2012 |
Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer.
Topics: Antimutagenic Agents; Axl Receptor Tyrosine Kinase; Blotting, Western; Cadherins; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Signaling Peptides and Proteins; Male; Neoplasm Metastasis; Prostatic Neoplasms; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tissue Array Analysis | 2012 |
Apolipoprotein A-I mimetic peptides inhibit expression and activity of hypoxia-inducible factor-1α in human ovarian cancer cell lines and a mouse ovarian cancer model.
Topics: Animals; Apolipoprotein A-I; Cell Line, Tumor; Cobalt; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Ovarian Neoplasms; Oxygen; Peptides; Peptidomimetics; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; Transcription, Genetic | 2012 |
Genotoxicity of cobalt nanoparticles and ions in Drosophila.
Topics: Animals; Cobalt; Drosophila melanogaster; Female; Gene Expression Regulation; Larva; Male; Metal Nanoparticles; Mutagenicity Tests | 2013 |
μ1- and 5-HT1-dependent mechanisms in the anterior pretectal nucleus mediate the antinociceptive effects of retrosplenial cortex stimulation in rats.
Topics: Animals; Atropine; Cerebral Cortex; Cobalt; Disease Models, Animal; Electric Stimulation Therapy; Male; Methiothepin; Naloxone; Pain Management; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, mu; Receptors, Serotonin, 5-HT1 | 2012 |
Alpha-mannosidase activity in stallion epididymal fluid and spermatozoa.
Topics: alpha-Mannosidase; Animals; Chlorides; Cobalt; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epididymis; Gene Expression Regulation, Enzymologic; Horses; Hydrogen-Ion Concentration; Male; Semen; Spermatozoa; Swainsonine; Zinc Compounds | 2012 |
Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line, Tumor; Cobalt; Colorectal Neoplasms; Gastrins; Gastrointestinal Neoplasms; Gastrointestinal Tract; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor | 2012 |
N-acetylcysteine protects against hypoxia mimetic-induced autophagy by targeting the HIF-1α pathway in retinal ganglion cells.
Topics: Acetylcysteine; Animals; Animals, Newborn; Autophagy; Cell Hypoxia; Cell Line; Cell Line, Transformed; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Drug Delivery Systems; Hypoxia-Inducible Factor 1, alpha Subunit; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retinal Ganglion Cells | 2012 |
Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1.
Topics: Cells, Cultured; Cobalt; Copper; Copper Sulfate; Ethylenediamines; Gene Silencing; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2012 |
Feeding in the dark: lateral-line-mediated prey detection in the peacock cichlid Aulonocara stuartgranti.
Topics: Animals; Cichlids; Cobalt; Hydrodynamics; Light; Mechanoreceptors; Predatory Behavior | 2012 |
Cobalt chloride improves angiogenic potential of CD133+ cells.
Topics: AC133 Antigen; Antigens, CD; Cell Hypoxia; Cell Movement; Cell Proliferation; Chemokine CXCL12; Cobalt; Endothelial Cells; Fetal Blood; Fibroblast Growth Factors; Gene Expression; Glycoproteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Neovascularization, Physiologic; Peptides; RNA, Messenger; Stem Cells; Vascular Endothelial Growth Factor A | 2012 |
Bone marrow-derived mesenchymal stem cells prevent the apoptosis of neuron-like PC12 cells via erythropoietin expression.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspases; Cell Hypoxia; Cells, Cultured; Cobalt; Cytoprotection; Erythropoietin; Gene Knockdown Techniques; Male; Mesenchymal Stem Cells; Neurons; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Up-Regulation | 2012 |
Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney.
Topics: Animals; Cell Line; Cobalt; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Heme Oxygenase (Decyclizing); Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Time Factors; Vascular Endothelial Growth Factor A | 2012 |
Presynaptic and postsynaptic single-unit responses in the goldfish tectum as revealed by a reversible synaptic transmission blocker.
Topics: Action Potentials; Animals; Cobalt; Goldfish; Neurons; Orientation; Photic Stimulation; Superior Colliculi; Synaptic Transmission; Time Factors; Visual Fields; Visual Pathways | 2012 |
Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs.
Topics: Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Diosgenin; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Integrin alpha5; Integrin beta Chains; Neoplasm Invasiveness; RNA, Small Interfering; Stomach Neoplasms | 2012 |
Molecular and catalytic properties of 2,4-diacetylphloroglucinol hydrolase (PhlG) from Pseudomonas sp. YGJ3.
Topics: Bacterial Proteins; Cloning, Molecular; Cobalt; Enzyme Activation; Enzyme Stability; Escherichia coli; Gene Expression; Hydrolases; Kinetics; Mercaptoethanol; Phloroglucinol; Pseudomonas; Recombinant Proteins; Substrate Specificity | 2012 |
Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Topics: Cobalt; Gene Deletion; Genome, Fungal; Membrane Transport Proteins; Mitogen-Activated Protein Kinases; Mutation; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Signal Transduction | 2012 |
Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α.
Topics: Amino Acids, Dicarboxylic; Cell Line; Cobalt; Deferoxamine; Down-Regulation; Eukaryotic Initiation Factor-2; HEK293 Cells; Humans; Hydrogen Sulfide; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit | 2012 |
Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adolescent; Adult; Cholestanetriol 26-Monooxygenase; Cobalt; Cytochrome P450 Family 2; Female; Humans; Oxidative Stress; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Receptors, Calcitriol; Steroid Hydroxylases; Superoxide Dismutase; Vitamin D; Vitamin D-Binding Protein; Vitamin D3 24-Hydroxylase; Young Adult | 2012 |
Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cells, Cultured; Cobalt; Cyclooxygenase 2; Disease Models, Animal; Electroretinography; Glial Fibrillary Acidic Protein; Hypoxia; Interleukin-1beta; Lutein; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroglia; NF-kappa B; Photic Stimulation; Rats; Reperfusion Injury; Retina; Retinal Diseases; Tumor Necrosis Factor-alpha | 2012 |
Hydrogen sulfide protects PC12 cells against reactive oxygen species and extracellular signal-regulated kinase 1/2-mediated downregulation of glutamate transporter-1 expression induced by chemical hypoxia.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Survival; Cobalt; Down-Regulation; Excitatory Amino Acid Transporter 2; Extracellular Signal-Regulated MAP Kinases; Hydrogen Sulfide; Kainic Acid; MAP Kinase Signaling System; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species | 2012 |
Magnetic properties of 1 : 4 complexes of CoCl2 and pyridines carrying carbenes (S(0) = 4/2, 6/2, and 8/2) in diluted frozen solution; influence of carbene multiplicity on heterospin single-molecule magnets.
Topics: Cobalt; Coordination Complexes; Freezing; Magnetics; Methane; Photolysis; Pyridines; Solutions; Temperature | 2012 |
Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Azo Compounds; Blotting, Western; Caco-2 Cells; Cell Nucleus; Cobalt; Coloring Agents; Fibroblast Growth Factors; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Oxidative Stress; PPAR alpha; PPAR gamma; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Superoxides; Triglycerides | 2012 |
Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation.
Topics: Animals; Benzoquinones; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Culture Media, Serum-Free; Gene Expression; Glucose; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Rats; Up-Regulation | 2012 |
Trigeminal interpolaris/caudalis transition neurons mediate reflex lacrimation evoked by bright light in the rat.
Topics: Animals; Cobalt; Evoked Potentials, Visual; Eye; Glare; Laser-Doppler Flowmetry; Male; Neurons; NG-Nitroarginine Methyl Ester; Nociception; Photic Stimulation; Photophobia; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Regional Blood Flow; Synaptic Transmission; Tears; Trigeminal Caudal Nucleus; Trigeminal Nerve | 2012 |
The hypoxia-mimetic agent cobalt chloride induces cell cycle arrest and alters gene expression in U266 multiple myeloma cells.
Topics: Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Transcriptome | 2012 |
Effect of CoCl(2) treatment on major and trace elements metabolism and protein concentration in mice.
Topics: Animals; Boron; Cobalt; Female; Metals; Mice; Mice, Inbred BALB C; Proteins; Silicon; Trace Elements | 2013 |
Augmentation of aerobic respiration and mitochondrial biogenesis in skeletal muscle by hypoxia preconditioning with cobalt chloride.
Topics: Aerobiosis; Animals; Cobalt; Energy Metabolism; Gene Expression Regulation; Hypoxia; Ischemic Preconditioning; Male; Mitochondrial Turnover; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Oxygen Consumption; Physical Endurance; Rats; Rats, Sprague-Dawley | 2012 |
Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia.
Topics: Animals; Antimutagenic Agents; Apoptosis; bcl-2-Associated X Protein; Berberine; Caspase 3; Caspase 9; Cell Survival; Cobalt; Coptis chinensis; Drugs, Chinese Herbal; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Neurons; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2012 |
Reactions of the cationic zinc thiolate model complex [Zn(Tab)4](PF6)2 with N-donor ligands and cobalt dichloride.
Topics: 2,2'-Dipyridyl; Cobalt; Coordination Complexes; Crystallography, X-Ray; Imidazoles; Ligands; Models, Molecular; Phenanthrolines; Pyridines; Sulfhydryl Compounds; Zinc | 2012 |
Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells.
Topics: Animals; Astragalus Plant; Cell Line, Tumor; Cobalt; Colonic Neoplasms; Cyclooxygenase 2; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2012 |
Ghrelin protects against cobalt chloride-induced hypoxic injury in cardiac H9c2 cells by inhibiting oxidative stress and inducing autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Catalase; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Ghrelin; Myocytes, Cardiac; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Oxidative Stress; Rats; Reactive Oxygen Species; RNA, Messenger; Structure-Activity Relationship; Superoxide Dismutase | 2012 |
Autophagic subpopulation sorting by sedimentation field-flow fractionation.
Topics: Autophagy; Caspase 3; Cathepsin B; Cell Hypoxia; Cell Line, Tumor; Cell Separation; Cobalt; Fractionation, Field Flow; Humans; Mutation; Neuroblastoma; Tumor Suppressor Protein p53 | 2012 |
Hard-metal (WC-Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1α, HMOX1, and p53 activation in human PBMC.
Topics: Cobalt; Dust; Gene Expression; Gene Expression Profiling; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhalation Exposure; Leukocytes, Mononuclear; Occupational Exposure; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Particulate Matter; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Tumor Suppressor Protein p53; Tungsten Compounds | 2013 |
Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells.
Topics: Amino Acids, Dicarboxylic; Cells, Cultured; Cobalt; Deferoxamine; Dental Pulp; Dental Pulp Capping; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mimosine; Neovascularization, Physiologic; Procollagen-Proline Dioxygenase; Regeneration; Siderophores; Vascular Endothelial Growth Factor A | 2012 |
Radioprotective effect on HepG2 cells of low concentrations of cobalt chloride: induction of hypoxia-inducible factor-1 alpha and clearance of reactive oxygen species.
Topics: Cell Survival; Cobalt; DNA Damage; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Metabolic Clearance Rate; Radiation Tolerance; Radiation-Protective Agents; Reactive Oxygen Species; Up-Regulation | 2013 |
High doses of cobalt induce optic and auditory neuropathy.
Topics: Animals; Chlorides; Chromium Compounds; Cobalt; Cochlea; Dose-Response Relationship, Drug; Female; Hair Cells, Auditory; Hearing Loss, Central; Heavy Metal Poisoning, Nervous System; Male; Microscopy, Electron; Optic Nerve; Rabbits; Retina; Retinal Ganglion Cells; Sciatic Nerve; Tissue Distribution; Ultrasonography | 2013 |
Ethylene inhibitors enhance shoot organogenesis of gloxinia (Sinningia speciosa).
Topics: Cobalt; Ethylenes; Glycine; Magnoliopsida; Organogenesis; Plant Growth Regulators; Plant Shoots; Thiosulfates | 2012 |
HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model.
Topics: 2-Methoxyestradiol; Animals; Cobalt; Cytokines; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoglobulin E; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred BALB C; Nasal Mucosa; Ovalbumin; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Signal Transduction; Vascular Endothelial Growth Factor A | 2012 |
Metabolic preconditioning of mammalian cells: mimetic agents for hypoxia lack fidelity in promoting phosphorylation of pyruvate dehydrogenase.
Topics: Amino Acids, Dicarboxylic; Animals; Blotting, Western; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Gene Expression Regulation, Enzymologic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mammals; Mice; Phosphorylation; Pyruvate Dehydrogenase Complex; RNA, Messenger | 2013 |
Caudal ventrolateral medulla mediates baroreceptor afferent inputs to subfornical organ angiotensin II responsive neurons.
Topics: Afferent Pathways; Angiotensin II; Animals; Baroreflex; Blood Pressure; Carotid Arteries; Cobalt; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Injections, Intra-Arterial; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Neurons; Pressoreceptors; Rats; Rats, Wistar; Subfornical Organ; Synapses | 2013 |
Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells.
Topics: Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Down-Regulation; Epidermal Growth Factor; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Ovarian Neoplasms; Snail Family Transcription Factors; Transcription Factors | 2013 |
Neuroprotective lignans from the stems of Schisandra glaucescens.
Topics: Cell Death; Cell Survival; Cobalt; Humans; Hydrogen Peroxide; Lignans; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Plant Extracts; Plant Stems; Schisandra; Tumor Cells, Cultured | 2012 |
Bacteriophages as templates for manufacturing supramolecular structures.
Topics: Bacteriophages; Biocompatible Materials; Bioengineering; Calcium Chloride; Capsid Proteins; Cobalt; Escherichia coli; Macromolecular Substances; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Recombinant Proteins; Static Electricity; Surface Properties; Virus Assembly | 2013 |
Microarray analysis of the hypoxia-induced gene expression profile in malignant C6 glioma cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cobalt; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glycolysis; Hypoxia; Oligonucleotide Array Sequence Analysis; Rats; Signal Transduction; Up-Regulation | 2012 |
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.
Topics: 3' Untranslated Regions; Activating Transcription Factor 4; Animals; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cell Hypoxia; Cell Nucleus; Cobalt; Endoplasmic Reticulum Stress; Enhancer Elements, Genetic; Erythropoietin; Hep G2 Cells; Humans; Kidney; Liver; Male; Protein Binding; Protein Transport; Rats; Rats, Wistar; Transcription, Genetic; Transcriptional Activation; Unfolded Protein Response | 2013 |
Protection of neuroblastoma Neuro2A cells from hypoxia-induced apoptosis by cyclic phosphatidic acid (cPA).
Topics: Animals; Apoptosis; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cobalt; Flow Cytometry; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Mice; Phosphatidic Acids; Reactive Oxygen Species | 2012 |
Dynamics of tumor hypoxia in response to patupilone and ionizing radiation.
Topics: Animals; Biomarkers, Tumor; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cobalt; Combined Modality Therapy; Epothilones; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Protein Structure, Tertiary; Radiation, Ionizing; Xenograft Model Antitumor Assays | 2012 |
Chloroquine enhances cobalt chloride-induced leukemic cell differentiation via the suppression of autophagy at the late phase.
Topics: Autophagy; Cell Differentiation; Cell Line, Tumor; Chloroquine; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 2; Phagosomes | 2013 |
All-trans retinoic acid protects renal tubular epithelial cells against hypoxia induced injury in vitro.
Topics: Animals; Blotting, Western; Carboxypeptidases; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Cytoprotection; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Epithelial Cells; Fibrosis; Gene Expression Regulation; Immunoprecipitation; Kidney Tubules, Proximal; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factor RelA; Tretinoin; Vascular Endothelial Growth Factor A | 2013 |
Effect of CoCl₂ on the content of different metals and a relative activity of DNA-hydrolyzing abzymes in the blood plasma of mice.
Topics: Animals; Antibodies, Catalytic; Cobalt; Deoxyribonucleases; DNA; Edetic Acid; Female; Hydrolysis; Immunoglobulin G; Metals; Mice; Mice, Inbred BALB C; Trace Elements | 2013 |
Investigating the effect of CoCl2 administration on diabetic nephropathy and associated aortic dysfunction.
Topics: Animals; Aorta, Thoracic; Cobalt; Diabetic Nephropathies; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2012 |
Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
Topics: Adiponectin; Adult; Aged; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cattle; Cell Hypoxia; Cell Movement; Cell Proliferation; Cobalt; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Protein Disulfide-Isomerases; RNA, Small Interfering; Synovial Membrane; Thioredoxins; Young Adult | 2013 |
Clinical-epidemiological features of contact dermatitis in rural and urban communities in northern Ethiopia: correlation with environmental or occupational exposure.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cobalt; Dermatitis, Allergic Contact; Eczema; Ethiopia; Female; Foot Dermatoses; Hand Dermatoses; Head; Humans; Male; Middle Aged; Neck; Nickel; Occupational Exposure; Patch Tests; Perfume; Phenylenediamines; Potassium Dichromate; Prevalence; Resins, Synthetic; Rural Population; Torso; Urban Population; Young Adult | 2014 |
Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation.
Topics: Animals; Cell Death; Cell Line; Cobalt; Curcumin; Endoplasmic Reticulum; Gene Expression Regulation; Hippocampus; Hypoxia; Mice; NF-kappa B; Oxidative Stress; Peptides; Peroxiredoxin VI; RNA, Messenger; Signal Transduction | 2013 |
Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Hypoxia; Cell Line, Tumor; Cobalt; Erythroid Cells; Erythroid Precursor Cells; Female; Fibroblasts; Genes, myc; Hemoglobins; Humans; Mice; Mice, SCID; Ovarian Neoplasms; Ovary; Spheroids, Cellular | 2013 |
Autophagy takes place in mutated p53 neuroblastoma cells in response to hypoxia mimetic CoCl(2).
Topics: Apoptosis; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cobalt; Humans; Mutation; Neuroblastoma; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2013 |
Protective action of erythropoietin on neuronal damage induced by activated microglia.
Topics: Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cobalt; Culture Media, Conditioned; Erythropoietin; Humans; Inflammation; Mice; Microglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase Type II; Nitrites; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Receptors, Erythropoietin; Tumor Necrosis Factor-alpha | 2013 |
Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1.
Topics: Cell Survival; Cobalt; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mesenchymal Stem Cells; MicroRNAs; Oxygen; Oxygen Consumption; RNA, Small Interfering | 2013 |
Low molecular weight fucoidan against renal ischemia-reperfusion injury via inhibition of the MAPK signaling pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line; Cell Survival; Cobalt; Cytochromes c; Humans; Male; Malondialdehyde; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Molecular Weight; Peroxidase; Phosphorylation; Polysaccharides; Proto-Oncogene Proteins c-bcl-2; Reperfusion Injury; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2013 |
Cobalt chloride induces metaphase when topically applied to larvae and pupae of the stingless bee Melipona scutellaris (Hymenoptera, Apidae, Meliponini).
Topics: Administration, Topical; Animals; Bees; Bites and Stings; Cobalt; Ganglia, Invertebrate; Larva; Metaphase; Micronucleus, Germline; Pupa | 2013 |
Magnetic resonance imaging (MRI) markers for MRI-guided high-dose-rate brachytherapy: novel marker-flange for cervical cancer and marker catheters for prostate cancer.
Topics: Brachytherapy; Catheters; Cobalt; Copper Sulfate; Feasibility Studies; Female; Fiducial Markers; Fish Oils; Humans; Iothalamate Meglumine; Magnetic Resonance Imaging, Interventional; Male; Phantoms, Imaging; Prostatic Neoplasms; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Sepharose; Sodium Chloride; Titanium; Tomography, X-Ray Computed; Uncertainty; Uterine Cervical Neoplasms; Vitamin E | 2013 |
A cell-penetrating peptide suppresses the hypoxia inducible factor-1 function by binding to the helix-loop-helix domain of the aryl hydrocarbon receptor nuclear translocator.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Death; Cell-Penetrating Peptides; Cobalt; Gene Products, tat; HeLa Cells; Helix-Loop-Helix Motifs; Humans; Protein Binding; Protein Refolding; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2013 |
Absorption measurements in liquid core waveguides using cavity ring-down spectroscopy.
Topics: Cobalt; DNA; Ferrous Compounds; Lasers; Organic Chemicals; Potassium Permanganate; Silicon Dioxide; Spectrometry, Fluorescence | 2013 |
The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.
Topics: Animals; Antibodies; Antimutagenic Agents; Cell Adhesion; Cell Hypoxia; Cobalt; Hematopoietic Stem Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; LDL-Receptor Related Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Proto-Oncogene Proteins c-kit; Receptors, LDL; Receptors, Urokinase Plasminogen Activator; Response Elements; Stem Cell Niche; U937 Cells | 2013 |
Allergic contact dermatitis to metal allergens in Iran.
Topics: Adolescent; Adult; Age of Onset; Allergens; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Iran; Logistic Models; Male; Metals; Nickel; Potassium Dichromate; Prevalence; Retrospective Studies; Risk Factors; Young Adult | 2013 |
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma.
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Prognosis; Protein Stability; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic; Vimentin | 2013 |
Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zinc.
Topics: Blotting, Western; Cell Line; Cobalt; Culture Media; Drug Synergism; Homeostasis; Humans; Lung; Mass Spectrometry; Zinc | 2013 |
Generation of cancer stem-like cells through the formation of polyploid giant cancer cells.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; Cell Cycle Proteins; Cell Differentiation; Cell Fusion; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cobalt; Drug Resistance, Neoplasm; Giant Cells; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Polyploidy; Spheroids, Cellular | 2014 |
Cobalt-catalyzed electrophilic amination of arylzincs with N-chloroamines.
Topics: Amination; Catalysis; Chloramines; Cobalt; Combinatorial Chemistry Techniques; Molecular Structure; Organometallic Compounds; Zinc | 2013 |
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression.
Topics: Animals; Blotting, Western; Chromatin Immunoprecipitation; Cobalt; Constitutive Androstane Receptor; Gene Expression Regulation; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1; Immunoprecipitation; Male; Mice; Mice, Inbred C3H; Phenobarbital; Plasmids; Real-Time Polymerase Chain Reaction; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear | 2013 |
Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Cerebral Hemorrhage; Cerebral Infarction; Cobalt; Disease Models, Animal; Free Radical Scavengers; Gene Expression Regulation; Glucose; Hemoglobins; Hyperbaric Oxygenation; Hyperglycemia; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Metalloproteases; Neurologic Examination; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spectrophotometry; Time Factors | 2013 |
Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Hypoxia; Cell Line, Tumor; Chick Embryo; Cobalt; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma; Up-Regulation | 2013 |
Protective effects of fractions from Pseudostellaria heterophylla against cobalt chloride-induced hypoxic injury in H9c2 cell.
Topics: Animals; Apoptosis; Cardiotonic Agents; Caryophyllaceae; Cell Line; Cell Survival; Cobalt; Hypoxia; L-Lactate Dehydrogenase; Malondialdehyde; Myocytes, Cardiac; Plant Extracts; Plant Roots; Rats; Reactive Oxygen Species; Superoxide Dismutase | 2013 |
Preparation of entangled nanocellulose fibers from APMP and its magnetic functional property as matrix.
Topics: Cellulose; Cobalt; Crystallization; Ferrous Compounds; Gels; Magnetic Fields; Nanofibers; Peroxides; Populus; Sonication; Spectroscopy, Fourier Transform Infrared; Surface Properties; Thermogravimetry; Wood; X-Ray Diffraction | 2013 |
Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Gene Silencing; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Time Factors; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2013 |
Toxicological evaluation of magnetic ionic liquids in human cell lines.
Topics: Caco-2 Cells; Cell Line; Cell Survival; Chlorides; Cobalt; Environmental Pollutants; Humans; Ionic Liquids; Magnetics; Manganese Compounds; Models, Chemical; Solvents | 2013 |
Cobalt chloride-induced lateral root formation in rice: the role of heme oxygenase.
Topics: Cobalt; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydrogen Peroxide; Nitric Oxide; Oryza; Plant Roots; Protoporphyrins | 2013 |
CoCl2 induces apoptosis through the mitochondria- and death receptor-mediated pathway in the mouse embryonic stem cells.
Topics: Animals; Apoptosis; Caspases; Cell Hypoxia; Cobalt; Cytochromes c; Embryonic Stem Cells; Fas Ligand Protein; fas Receptor; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; Mice; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Death Domain; Signal Transduction; Transcriptional Activation; Tumor Suppressor Protein p53 | 2013 |
Electron yield soft X-ray photoabsorption spectroscopy under normal ambient-pressure conditions.
Topics: Air Pressure; Cobalt; Electrons; Equipment Design; Equipment Failure Analysis; Photoelectron Spectroscopy; Synchrotrons | 2013 |
Reversible carbon-carbon bond formation induced by oxidation and reduction at a redox-active cobalt complex.
Topics: Carbon; Cobalt; Coordination Complexes; Electrons; Imines; Models, Molecular; Nitrogen; Oxidation-Reduction; Pyridines; Quantum Theory | 2013 |
Inhibition of ROS-activated p38MAPK pathway is involved in the protective effect of H2S against chemical hypoxia-induced inflammation in PC12 cells.
Topics: Animals; Cobalt; Hydrogen Sulfide; Hypoxia; Inflammation; Interleukin-6; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species | 2013 |
Metal ions activate vascular endothelial cells and increase lymphocyte chemotaxis and binding.
Topics: Blotting, Western; Cell Adhesion; Cell Survival; Chemokine CCL2; Chemotaxis, Leukocyte; Chlorides; Chromium Compounds; Cobalt; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Ions; Jurkat Cells; Lymphocytes; Metal-on-Metal Joint Prostheses; Up-Regulation | 2013 |
Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes.
Topics: Alkalies; Animals; Base Sequence; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Cobalt; Cytoplasm; Dose-Response Relationship, Drug; Gene Expression; Growth Hormone; Hydrogen-Ion Concentration; Hypoxia-Inducible Factor 1; Luciferases; Lymphocytes; Male; Mice; Nucleotide Motifs; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Response Elements; Up-Regulation | 2013 |
CoCl2 induces PC12 cells apoptosis through p53 stability and regulating UNC5B.
Topics: Animals; Apoptosis; Caspase 3; Cell Death; Cell Line, Tumor; Cobalt; Nerve Growth Factors; Netrin-1; PC12 Cells; Rats; Receptors, Cell Surface; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2013 |
Stanniocalcin-1 protects retinal ganglion cells by inhibiting apoptosis and oxidative damage.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cobalt; Cytoprotection; Glycoproteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intravitreal Injections; Male; Optic Nerve Injuries; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retinal Ganglion Cells | 2013 |
NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats.
Topics: Animals; Cobalt; Excitatory Amino Acid Antagonists; Hemodynamics; Hypothalamic Area, Lateral; Isoquinolines; Male; Mice; Neural Inhibition; Parasympatholytics; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Stress, Physiological; Tropanes | 2013 |
Neuroprotective compounds from the bulbs of Lycoris radiata.
Topics: Amaryllidaceae Alkaloids; Amyloid beta-Peptides; Cell Death; China; Cobalt; Humans; Hydrogen Peroxide; Indole Alkaloids; Lycoris; Molecular Structure; Neuroprotective Agents; Plant Extracts; Plant Roots | 2013 |
Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Bone Marrow Cells; Cell Hypoxia; Cell Movement; Cells, Cultured; Cobalt; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Magnetic Resonance Imaging; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Vascular Endothelial Growth Factor A | 2013 |
Cobalt triggers necrotic cell death and atrophy in skeletal C2C12 myotubes.
Topics: Atrophy; Autophagy; Blotting, Western; Cell Death; Cell Line; Cobalt; Coloring Agents; Fluorometry; Immunohistochemistry; Indicators and Reagents; Muscle Fibers, Skeletal; Myoblasts; Necrosis; NF-kappa B; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Prostheses and Implants; Proteasome Endopeptidase Complex; Real-Time Polymerase Chain Reaction; Signal Transduction; Tetrazolium Salts; Thiazoles | 2013 |
Novitas in antiquo: magnetic nails.
Topics: Adult; Cobalt; Cosmetics; Dermatitis, Allergic Contact; Female; Humans; Magnetic Phenomena; Nails; Nickel; Patch Tests | 2013 |
Preconditioning and post-treatment with cobalt chloride in rat model of perinatal hypoxic-ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Capillaries; Cobalt; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Injections, Subcutaneous; Maze Learning; Memory Disorders; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2014 |
Combined treatment of glibenclamide and CoCl2 decreases MMP9 expression and inhibits growth in highly metastatic breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cobalt; Female; Gene Expression Regulation, Neoplastic; Glyburide; Humans; Matrix Metalloproteinase 9; Mice; Neoplasm Metastasis; Proliferating Cell Nuclear Antigen; RNA, Messenger; Tumor Burden | 2013 |
[Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-to-mesenchymal transition in rats].
Topics: Actins; Angiotensin I; Animals; Cell Line; Cobalt; Collagen Type I; Epithelial-Mesenchymal Transition; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peptide Fragments; Rats | 2013 |
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Cyclic S-Oxides; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Melatonin; Neovascularization, Pathologic; p300-CBP Transcription Factors; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2013 |
Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl₂ and H₂O₂-induced SH-SY5Y cell injuries.
Topics: Cell Death; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lycoris; Neuroprotective Agents; Plant Extracts; Plant Roots | 2014 |
Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).
Topics: Alternative Splicing; Base Sequence; Case-Control Studies; Cell Line; Cobalt; Deferoxamine; Ferrochelatase; Gene Expression Regulation; Gene Order; Gene Silencing; Genotype; Humans; Introns; Iron; Jumonji Domain-Containing Histone Demethylases; K562 Cells; Ketoglutaric Acids; Molecular Sequence Data; Mutation; Nuclear Proteins; Polymorphism, Single Nucleotide; Protoporphyria, Erythropoietic; Ribonucleoproteins; RNA Interference; RNA, Messenger; Sequence Alignment; Splicing Factor U2AF | 2013 |
Effects of ginkgo biloba extract on cultured human retinal pigment epithelial cells under chemical hypoxia.
Topics: Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Cobalt; Ginkgo biloba; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Macular Degeneration; Plant Extracts; Retinal Pigment Epithelium; RNA, Messenger; Vascular Endothelial Growth Factor A | 2013 |
Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.
Topics: Adenosine Triphosphatases; Animals; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Biological Transport; Cation Transport Proteins; Cell Hypoxia; Cell Line; Chromatin Immunoprecipitation; Cobalt; Copper; Copper-Transporting ATPases; Epithelial Cells; Gene Expression Regulation; Intestinal Mucosa; Iron; Iron Deficiencies; Phosphorylation; Plicamycin; Promoter Regions, Genetic; Protein Binding; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sp1 Transcription Factor; Up-Regulation | 2013 |
Analysis of contact allergens in korean polysensitized patients by patch testing: a pilot study.
Topics: 2-Naphthylamine; Adult; Asian People; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Hydrocortisone; Male; Mercury; Multiple Chemical Sensitivity; Neomycin; Nickel; Patch Tests; Phenylenediamines; Pilot Projects; Potassium Dichromate; Quinolines; Republic of Korea; Sulfhydryl Compounds; Thiram | 2014 |
Age-related decline in oligodendrogenesis retards white matter repair in mice.
Topics: Aging; Animals; Antimutagenic Agents; Cells, Cultured; Cobalt; Cognition Disorders; Corpus Callosum; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hypoxia, Brain; Leukoencephalopathies; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neural Stem Cells; Neurogenesis; Neuroprotective Agents | 2013 |
Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine.
Topics: Adipose Tissue; Antioxidants; Biomarkers; Cobalt; Culture Media, Conditioned; Deferoxamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neovascularization, Physiologic; Paracrine Communication; Stem Cells; Vascular Endothelial Growth Factor A | 2016 |
The role of HIF in cobalt-induced ischemic tolerance.
Topics: Amino Acids, Dicarboxylic; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Cobalt; Deferoxamine; Erythropoietin; Hippocampus; Hypoxia-Inducible Factor 1; Immunohistochemistry; Ischemic Preconditioning; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Prolyl-Hydroxylase Inhibitors | 2013 |
Role of hypoxia inducible factor-1α in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer.
Topics: Alternative Splicing; Cell Hypoxia; Cell Line, Tumor; Cobalt; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Organ Specificity; Organic Anion Transporters, Sodium-Independent; Oxygen; Pancreatic Neoplasms; Protein Binding; Response Elements; RNA, Small Interfering; Signal Transduction; Solute Carrier Organic Anion Transporter Family Member 1B3; Transcription, Genetic | 2013 |
Solvent-dependent assembly of discrete and continuous CoCl₂ adamantane-based ligand complexes: observations by CSI-mass spectrometry and X-ray crystallography.
Topics: Adamantane; Cobalt; Crystallography, X-Ray; Ligands; Mass Spectrometry; Models, Molecular; Solvents | 2013 |
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Topics: Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cobalt; Deferoxamine; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphoglycerate Kinase; Promoter Regions, Genetic; Propanolamines; Protein Binding; Pyrrolidines; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Upstream Stimulatory Factors | 2013 |
RTP801 immunoreactivity in retinal ganglion cells and its down-regulation in cultured cells protect them from light and cobalt chloride.
Topics: Animals; Antimutagenic Agents; Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Transformed; Cobalt; Dose-Response Relationship, Drug; Down-Regulation; Humans; Immunosuppressive Agents; Kidney; Light; Mice; Proton Ionophores; Rats; Rats, Wistar; Reactive Oxygen Species; Repressor Proteins; Retina; Retinal Ganglion Cells; Transcription Factors | 2013 |
Ginsenoside Rb1 protects rat retinal ganglion cells against hypoxia and oxidative stress.
Topics: Animals; Antimutagenic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Cobalt; Ginsenosides; Hydrogen Peroxide; Hypoxia; Neuroprotective Agents; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; RNA, Messenger | 2013 |
[Expression of integrin-linked kinase in fibroblasts of scar induced by cobalt chloride and its effect on cell proliferation].
Topics: Cell Proliferation; Cells, Cultured; Cicatrix; Cobalt; Fibroblasts; Humans; Protein Serine-Threonine Kinases | 2013 |
Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective.
Topics: Animals; Cell Death; Cell Differentiation; Cell Line; Chick Embryo; Chromans; Cobalt; Doublecortin Domain Proteins; Doublecortin Protein; Flavanones; Flavonoids; Ganglia, Spinal; Mice; Microtubule-Associated Proteins; Neural Stem Cells; Neurites; Neurogenesis; Neuropeptides; PC12 Cells; Propiophenones; Rats; Tumor Cells, Cultured | 2013 |
The Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT/HIF-1β) is influenced by hypoxia and hypoxia-mimetics.
Topics: Amino Acids, Dicarboxylic; Antimutagenic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Hypoxia; Cell Line, Tumor; Cobalt; HeLa Cells; Humans; Immunoblotting | 2013 |
Autophagy induced by HIF1α overexpression supports trophoblast invasion by supplying cellular energy.
Topics: Adenosine Triphosphate; Autophagy; Cell Adhesion; Cell Line; Cell Movement; Cobalt; Decidua; Energy Metabolism; Female; Gene Expression Regulation, Developmental; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 9; Pregnancy; Pregnancy Trimester, First; Receptors, Purinergic P2X7; Signal Transduction; Trophoblasts | 2013 |
Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; RNA, Messenger; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2013 |
Linking ethylene to nitrogen-dependent leaf longevity of grass species in a temperate steppe.
Topics: Agropyron; China; Cobalt; Ecosystem; Ethylenes; Nitrogen; Plant Leaves | 2013 |
Hypoxia-mimetic effects in the secretome of human preadipocytes and adipocytes.
Topics: Adipocytes, White; Antimutagenic Agents; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Humans; Proteome; Secretory Pathway; Stem Cells | 2013 |
Synthesis and protective effect of new ligustrazine-benzoic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells.
Topics: Animals; Benzoates; Cell Differentiation; Cell Proliferation; Cell Survival; Cobalt; Inhibitory Concentration 50; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats | 2013 |
Dorsal and ventral hippocampus modulate autonomic responses but not behavioral consequences associated to acute restraint stress in rats.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Cobalt; Heart Rate; Hippocampus; Male; Maze Learning; Muscle, Skeletal; Rats; Rats, Wistar; Restraint, Physical; Skin; Stress, Psychological; Temperature | 2013 |
Locally applied valproate enhances survival in rats after neocortical treatment with tetanus toxin and cobalt chloride.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cobalt; Disease Models, Animal; Electroencephalography; Epilepsy; Rats; Rats, Sprague-Dawley; Tetanus Toxin; Valproic Acid | 2013 |
Fluidized-bed denitrification for mine waters. Part II: effects of Ni and Co.
Topics: Batch Cell Culture Techniques; Biodegradation, Environmental; Bioreactors; Cobalt; Denitrification; Humans; Hydrogen-Ion Concentration; Kinetics; Microbial Consortia; Mining; Nickel; Nitrates; Oxidation-Reduction; Temperature; Water Pollutants, Chemical | 2014 |
Autophagy triggered by magnolol derivative negatively regulates angiogenesis.
Topics: Animals; Autophagy; Biphenyl Compounds; Cell Cycle; Cell Death; Cell Line; Cell Proliferation; Cobalt; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Microtubule-Associated Proteins; Neovascularization, Pathologic; Phenols; Rats; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Paraventricular nucleus of hypothalamus participates in the sympathetic modulation and spontaneous fluctuation of baroreflex during head up tilt in unanesthetized rats.
Topics: Animals; Baroreflex; Blood Pressure; Calcium Channel Blockers; Cobalt; GABA-A Receptor Agonists; Heart Rate; Male; Muscimol; Paraventricular Hypothalamic Nucleus; Posture; Rats, Wistar; Sympathetic Nervous System | 2014 |
Patch test reactions to metal salts in patients with different types of dermatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Contact; Humans; Middle Aged; Nickel; Patch Tests; Trace Elements; Young Adult | 2013 |
Hypoxia-inducible factor-1α (HIF-1α) protein diminishes sodium glucose transport 1 (SGLT1) and SGLT2 protein expression in renal epithelial tubular cells (LLC-PK1) under hypoxia.
Topics: Animals; Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Cobalt; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Tubules; RNA, Messenger; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Swine; Time Factors | 2014 |
Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Bronchoalveolar Lavage Fluid; Cobalt; Cytokines; Disease Models, Animal; Doxycycline; Gene Expression Profiling; Immunohistochemistry; Lung Injury; Mice; Mice, Knockout; Pulmonary Alveoli; Pulmonary Eosinophilia; Respiratory Mucosa | 2014 |
Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cobalt; Intracellular Signaling Peptides and Proteins; Neurons; Neuropeptides; Neuroprotective Agents; Orexins; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction | 2014 |
Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortitis; Calcium Chloride; Catalase; Cobalt; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix; Hypoxia-Inducible Factor-Proline Dioxygenases; Inflammation Mediators; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Phosphorylation; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Transcription Factor RelA | 2014 |
Hypoxia and hypoxia mimetic cooperate to counteract tumor cell resistance to glucose starvation preferentially in tumor cells with mutant p53.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cobalt; Glucose; Humans; L-Lactate Dehydrogenase; Mutation; Neoplasms; Oxygen; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2014 |
Resveratrol attenuates CoCl2-induced cochlear hair cell damage through upregulation of Sirtuin1 and NF-κB deacetylation.
Topics: Acetylation; Animals; Cell Death; Cobalt; Hair Cells, Auditory; NF-kappa B; Rats, Wistar; Resveratrol; RNA, Messenger; Sirtuin 1; Stilbenes; Up-Regulation | 2013 |
Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum.
Topics: Acetyl Coenzyme A; ATP Citrate (pro-S)-Lyase; Benzopyrans; Cobalt; Fungal Proteins; Fusarium; Gene Expression Regulation, Fungal; Proteome; RNA, Messenger; Trichothecenes; Up-Regulation | 2013 |
Hypoxia induces cell damage via oxidative stress in retinal epithelial cells.
Topics: Aldehydes; Apoptosis; Cell Hypoxia; Cells, Cultured; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoprostanes; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Retinal Diseases; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A | 2014 |
Stabilization of hypoxia inducible factor-1α ameliorates acute renal neurogenic hypertension.
Topics: Animals; Blood Pressure; Cobalt; Gene Expression; Heme Oxygenase (Decyclizing); Hypertension, Renal; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Phenol; Rats; Rats, Sprague-Dawley; Sympathectomy; Sympathetic Nervous System; Vascular Resistance; Vasoconstriction | 2014 |
Activation of vitamin D receptor promotes VEGF and CuZn-SOD expression in endothelial cells.
Topics: Calcitriol; Cobalt; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Oxidative Stress; Receptors, Calcitriol; Superoxide Dismutase; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Resveratrol inhibits proliferation of hypoxic choroidal vascular endothelial cells.
Topics: Antioxidants; Caspase 3; Cell Hypoxia; Cell Line; Cell Proliferation; Cell Survival; Choroid; Cobalt; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 8; Resveratrol; Signal Transduction; Stilbenes; Vascular Endothelial Growth Factor A | 2013 |
Role of oxygen in the regulation of Leydig tumor derived MA-10 cell steroid production: the effect of cobalt chloride.
Topics: Base Sequence; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Cobalt; Culture Media; DNA Primers; Humans; Leydig Cell Tumor; Oxygen; Phosphoproteins; Progesterone; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2014 |
The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines.
Topics: Ascorbic Acid; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Culture Media; Dose-Response Relationship, Drug; G1 Phase; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Intracellular Space; Oxygen; Partial Pressure; Peroxides; Reactive Oxygen Species | 2014 |
H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2.
Topics: Acetylcysteine; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; Cyclooxygenase 2; Down-Regulation; Epoprostenol; Familial Primary Pulmonary Hypertension; Humans; Hydrogen Peroxide; Hydrogen Sulfide; Hypertension, Pulmonary; Myocytes, Smooth Muscle; Oxidative Stress; Pulmonary Artery; Reactive Oxygen Species; Sulfides | 2014 |
iTRAQ-based proteomic analysis of polyploid giant cancer cells and budding progeny cells reveals several distinct pathways for ovarian cancer development.
Topics: Animals; Blotting, Western; Cell Cycle; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cobalt; Epithelial-Mesenchymal Transition; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplastic Stem Cells; Ovarian Neoplasms; Polyploidy; Proteomics; Spectrometry, Mass, Electrospray Ionization | 2013 |
Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection.
Topics: Animals; bcl-2-Associated X Protein; Cell Line; Cobalt; Gene Expression; Gene Expression Regulation; Genes, Reporter; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Oxidative Stress; Promoter Regions, Genetic; Protein Binding; Rats; Repressor Proteins; RNA Interference; Transcriptional Activation | 2013 |
Exposure to cobalt causes transcriptomic and proteomic changes in two rat liver derived cell lines.
Topics: Animals; Biomarkers; Cell Line; Cluster Analysis; Cobalt; Computational Biology; Energy Metabolism; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Mass Spectrometry; Metabolic Networks and Pathways; Oxidative Stress; Proteome; Proteomics; Rats; Signal Transduction; Transcriptome | 2013 |
Ginsenoside Rg-1 protects retinal pigment epithelium (RPE) cells from cobalt chloride (CoCl2) and hypoxia assaults.
Topics: Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Cytoprotection; Enzyme Activation; Ginsenosides; Humans; Mechanistic Target of Rapamycin Complex 1; Mitogen-Activated Protein Kinases; Multiprotein Complexes; Reactive Oxygen Species; Retinal Pigment Epithelium; TOR Serine-Threonine Kinases | 2013 |
Increased NFAT5 expression stimulates transcription of Hsp70 in preeclamptic placentas.
Topics: Cell Hypoxia; Cell Line, Tumor; Choriocarcinoma; Cobalt; Disulfides; Female; Gene Knockdown Techniques; HSP70 Heat-Shock Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Indole Alkaloids; Placenta; Pre-Eclampsia; Pregnancy; RNA, Small Interfering; Transcription Factors | 2014 |
The pronociceptive dorsal reticular nucleus contains mostly tonic neurons and shows a high prevalence of spontaneous activity in block preparation.
Topics: Animals; Animals, Newborn; Biophysics; Cobalt; Computer Simulation; Electric Stimulation; Membrane Potentials; Models, Neurological; Nerve Net; Neural Pathways; Neurons; Nociception; Patch-Clamp Techniques; Rats; Rats, Wistar; Reticular Formation; Synaptic Potentials | 2014 |
NF-κB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A(2A) receptors.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunosuppression Therapy; Isoquinolines; NF-kappa B; Receptor, Adenosine A2A; Signal Transduction; Sulfites; Sulfonamides; T-Lymphocytes; Triazines; Triazoles; Up-Regulation | 2014 |
Cobalt chloride induces neuronal differentiation of human mesenchymal stem cells through upregulation of microRNA-124a.
Topics: Cell Line; Cobalt; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mesenchymal Stem Cells; MicroRNAs; Neurogenesis; Neurons; SOX9 Transcription Factor; Up-Regulation | 2014 |
A lipidomics investigation of the induced hypoxia stress on HeLa cells by using MS and NMR techniques.
Topics: Biomarkers; Cell Hypoxia; Cell Line, Tumor; Chromatography, Liquid; Cobalt; HeLa Cells; Humans; Lipid Metabolism; Lysophosphatidylcholines; Lysophospholipids; Magnetic Resonance Imaging; Mass Spectrometry; Membrane Lipids; Phosphatidylinositols; Stress, Physiological | 2014 |
Calculation of hygroscopic particle deposition in the human lung.
Topics: Absorption; Aerosols; Air Pollutants; Cobalt; Humans; Inhalation Exposure; Lung; Models, Biological; Particulate Matter; Sodium Chloride; Stochastic Processes; Tissue Distribution; Water; Zinc Sulfate | 2014 |
Cobalt(II) chloride complexes with 1,1'-dimethyl-4,4'-bipyrazole featuring first- and second-sphere coordination of the ligand.
Topics: Cobalt; Coordination Complexes; Crystallography, X-Ray; Hydrogen Bonding; Ligands; Molecular Structure; Pyrazoles | 2014 |
Hypoxia inducible factor-1α directly regulates nuclear clusterin transcription by interacting with hypoxia response elements in the clusterin promoter.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Clusterin; Cobalt; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Oxygen; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Isoforms | 2014 |
Sorafenib blocks the HIF-1α/VEGFA pathway, inhibits tumor invasion, and induces apoptosis in hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Niacinamide; Phenylurea Compounds; RNA, Messenger; Sorafenib; Vascular Endothelial Growth Factor A | 2014 |
Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish.
Topics: Animals; Behavior, Animal; Chromates; Cobalt; Fish Proteins; Gene Expression Profiling; Gene Expression Regulation; Gills; Intestines; Male; Nickel; Olfactory Mucosa; Oligonucleotide Array Sequence Analysis; Pharynx; Water Pollutants, Chemical; Zebrafish | 2014 |
Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
Topics: Animals; Apoptosis; Cation Transport Proteins; Cell Movement; Cell Proliferation; Chelating Agents; Cobalt; Copper; Down-Regulation; Gene Knockdown Techniques; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Proliferating Cell Nuclear Antigen; Protein-Lysine 6-Oxidase; Proto-Oncogene Proteins c-bcl-2; Pulmonary Artery; RNA, Messenger; RNA, Small Interfering; Up-Regulation | 2014 |
FTIR and UV-vis diffuse reflectance spectroscopy studies of the wet chemical (WC) route synthesized nano-structure CoFe(2)O(4) from CoCl(2) and FeCl(3).
Topics: Chlorides; Cobalt; Ferric Compounds; Ferrous Compounds; Nanoparticles; Semiconductors; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2014 |
Simplified system to investigate alteration of retinal neurons in diabetes.
Topics: Animals; Antimutagenic Agents; Biomarkers; Cobalt; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Hypoxia; Mice; Mice, Inbred C57BL; Retina; Retinal Neurons | 2014 |
HIF-1α-induced HSP70 regulates anabolic responses in articular chondrocytes under hypoxic conditions.
Topics: Aerobiosis; Animals; Cartilage, Articular; Cell Hypoxia; Cell Survival; Cells, Cultured; Chondrocytes; Cobalt; HSP70 Heat-Shock Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Rabbits; RNA, Small Interfering | 2014 |
Sp1 modification of human endothelial nitric oxide synthase promoter increases the hypoxia-stimulated activity.
Topics: Base Sequence; Binding Sites; Cell Hypoxia; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Molecular Sequence Data; Nitric Oxide Synthase Type III; Promoter Regions, Genetic; Regulatory Elements, Transcriptional; Sp1 Transcription Factor; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2014 |
Matriptase autoactivation is tightly regulated by the cellular chemical environments.
Topics: Blotting, Western; Cadmium Chloride; Cell Line; Cell-Free System; Cellular Microenvironment; Cobalt; Cytosol; Enzyme Activation; Humans; Hydrogen-Ion Concentration; RNA, Small Interfering; Serine Endopeptidases | 2014 |
Cobalt asthma in metalworkers from an automotive engine valve manufacturer.
Topics: Adult; Asthma, Occupational; Automobiles; Cobalt; Female; Humans; Inhalation Exposure; Male; Manufacturing Industry; Middle Aged; Occupational Exposure; Occupations; Respiratory Function Tests; Sex Factors; Skin Tests; United Kingdom | 2014 |
Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Autophagy; Cardiotonic Agents; Cell Line; Cobalt; Cytoprotection; Hepatocyte Growth Factor; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-met; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post-ictal antinociception.
Topics: Animals; Catheters, Indwelling; Central Nervous System Agents; Cobalt; Male; Nociception; Pain Measurement; Pain Perception; Pain Threshold; Pedunculopontine Tegmental Nucleus; Pentylenetetrazole; Rats, Wistar; Reticular Formation; Seizures; Synapses; Tail; Time Factors | 2014 |
Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
Topics: Amino Acid Sequence; Animals; Cattle; Cells, Cultured; Chemokine CXCL12; Chorionic Gonadotropin; Cobalt; Colforsin; Epidermal Growth Factor; Estrus; Female; Gene Expression Regulation; Granulosa Cells; Horses; Humans; Mifepristone; Molecular Sequence Data; Ovulation; Protein Kinase Inhibitors; Receptors, CXCR4; RNA, Messenger; Signal Transduction; Theca Cells | 2014 |
A redox-silent analogue of tocotrienol inhibits cobalt(II) chloride-induced VEGF expression via Yes signaling in mesothelioma cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Survival; Cobalt; Gene Expression; Humans; Hypoxia; Mesothelioma; Oxidation-Reduction; Proto-Oncogene Proteins c-yes; Signal Transduction; Tocotrienols; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells.
Topics: Anemia, Sickle Cell; Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Myocytes, Smooth Muscle; Penis; Priapism; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; RNA Interference; RNA, Small Interfering; Salivary Proteins and Peptides; Up-Regulation | 2014 |
The cytotoxicity and genotoxicity of soluble and particulate cobalt in human lung fibroblast cells.
Topics: Biological Transport; Carcinogens, Environmental; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cobalt; DNA Fragmentation; Humans; Lung; Mutagens; Osmolar Concentration; Oxides; Particle Size; Phagocytosis; Solubility | 2014 |
Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.
Topics: Antipyrine; Cell Hypoxia; Cell Line; Cobalt; Edaravone; Female; Free Radical Scavengers; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Reactive Oxygen Species; RNA, Messenger; Trophoblasts; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Carbonic Anhydrases; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Chick Embryo; Cobalt; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Neoplasms, Experimental; Neoplastic Stem Cells; Pancreatic Neoplasms; Phenanthrenes | 2014 |
Contact dermatitis to cobalt chloride with an unusual mechanism.
Topics: Adult; Allergens; Artificial Limbs; Cobalt; Dermatitis, Allergic Contact; Female; Femoral Neoplasms; Humans; Osteosarcoma; Prosthesis Design | 2015 |
Tougu Xiaotong capsule promotes chondrocyte autophagy by regulating the Atg12/LC3 conjugation systems.
Topics: Apoptosis; Autophagy; Autophagy-Related Protein 12; Cartilage; Cell Line; Chondrocytes; Cobalt; Drugs, Chinese Herbal; Humans; Microtubule-Associated Proteins; Osteoarthritis; Phagosomes; Small Ubiquitin-Related Modifier Proteins | 2014 |
Fasudil reduces GFAP expression after hypoxic injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cell Hypoxia; Cell Line, Tumor; Cobalt; Glial Fibrillary Acidic Protein; Gliosis; Humans; Male; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; Spinal Cord | 2014 |
Controllable electrofusion of lipid vesicles: initiation and analysis of reactions within biomimetic containers.
Topics: Biomimetic Materials; Chelating Agents; Cobalt; Coordination Complexes; Dimethylpolysiloxanes; Edetic Acid; Electrochemical Techniques; Equipment Design; Fluorescence Resonance Energy Transfer; Kinetics; Materials Testing; Membrane Fusion; Microchemistry; Microelectrodes; Microfluidic Analytical Techniques; Microscopy, Electron, Scanning; Particle Size; Printing, Three-Dimensional; Surface Properties; Unilamellar Liposomes | 2014 |
CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.
Topics: Adenocarcinoma; Cell Division; Cell Hypoxia; Cell Line, Tumor; Cell Shape; Cobalt; Colonic Neoplasms; Cyclin D1; DNA, Neoplasm; Drug Resistance, Neoplasm; Fluorouracil; G2 Phase; Giant Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Hybridization, Fluorescence; Neoplasm Proteins; Neoplastic Stem Cells; Organoplatinum Compounds; Oxaliplatin; Polyploidy; Protein Isoforms; Tumor Suppressor Protein p53 | 2014 |
The effects of CoCl2 on HIF-1α protein under experimental conditions of autoprogressive hypoxia using mouse models.
Topics: Animals; Cobalt; DNA; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Models, Animal; Protein Binding; RNA, Messenger; Vascular Endothelial Growth Factor A | 2014 |
Development of a novel neuroprotective strategy: combined treatment with hypothermia and valproic acid improves survival in hypoxic hippocampal cells.
Topics: Acetylation; Animals; beta Catenin; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Combined Modality Therapy; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Histone Deacetylase Inhibitors; Histones; HMGB1 Protein; Hypothermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Mice; Neuroprotective Agents; Phosphorylation; Valproic Acid | 2014 |
Initiation of premature senescence by Bcl-2 in hypoxic condition.
Topics: Animals; beta-Galactosidase; Cell Hypoxia; Cell Line, Tumor; Cellular Senescence; Cobalt; Gene Expression Regulation, Neoplastic; Melanoma, Experimental; Mice; Phenotype; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Signal Transduction; Skin Neoplasms; Time Factors; Transfection; Up-Regulation | 2014 |
Hypoxia inducible factor-1 is involved in growth factor, glucocorticoid and hypoxia mediated regulation of vascular endothelial growth factor-A in human meningiomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Cobalt; Dexamethasone; Dose-Response Relationship, Drug; Female; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1; Male; Meningioma; Middle Aged; Transforming Growth Factor alpha; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2014 |
A feedback regulatory loop between HIF-1α and miR-21 in response to hypoxia in cardiomyocytes.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cobalt; Feedback, Physiological; Gene Expression Regulation; Gene Silencing; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; MicroRNAs; Myocytes, Cardiac; p300-CBP Transcription Factors; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Transcription, Genetic | 2014 |
Effects of Salidroside on cobalt chloride-induced hypoxia damage and mTOR signaling repression in PC12 cells.
Topics: Animals; Cell Culture Techniques; Cell Hypoxia; Cell Survival; Cobalt; Glucosides; Neurons; Neuroprotective Agents; PC12 Cells; Phenols; Rats; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Bevacizumab modulates the process of fibrosis in vitro.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antimutagenic Agents; Bevacizumab; Blotting, Western; Cell Hypoxia; Cells, Cultured; Cobalt; Connective Tissue Growth Factor; Cytokines; Enzyme-Linked Immunosorbent Assay; Fibroblast Growth Factor 2; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Matrix Metalloproteinase 2; Real-Time Polymerase Chain Reaction; Retinal Vessels; RNA, Messenger; Transforming Growth Factor beta2; Vascular Endothelial Growth Factor A | 2015 |
Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Proliferation; Cobalt; Embryo, Nonmammalian; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Hepatocyte Growth Factor; Intestines; Liver; Organ Size; Pancreas, Exocrine; Phenotype; Promoter Regions, Genetic; Response Elements; Transcription, Genetic; Wnt Signaling Pathway; Zebrafish; Zebrafish Proteins | 2014 |
Cellulolytic and xylanolytic enzymes from thermophilic Aspergillus terreus RWY.
Topics: Aspergillus; Cellulases; Chlorides; Cobalt; Endo-1,4-beta Xylanases; Enzyme Stability; Ferrous Compounds; Hydrogen-Ion Concentration; Manganese Compounds | 2014 |
CoCl2-induced biochemical hypoxia down regulates activities and expression of super oxide dismutase and catalase in cerebral cortex of mice.
Topics: Animals; Blotting, Western; Catalase; Cerebral Cortex; Cobalt; Dose-Response Relationship, Drug; Down-Regulation; Hypoxia; Male; Mice; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase | 2014 |
Effects of chemically induced hypoxia on in vitro expression of hypoxia inducible factor-lα, vascular endothelial growth factor, aggrecanase-1, and tissue inhibitor of metalloproteinase-3 in rat mandibular condylar chondrocytes.
Topics: ADAM Proteins; ADAMTS4 Protein; Animals; Cartilage, Articular; Cell Culture Techniques; Cell Hypoxia; Cell Proliferation; Cell Shape; Cells, Cultured; Cellular Microenvironment; Chondrocytes; Cobalt; Collagen Type II; Female; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate Dehydrogenase; Mandibular Condyle; Oxygen Consumption; Procollagen N-Endopeptidase; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Inhibitor of Metalloproteinase-3; Vascular Endothelial Growth Factor A | 2014 |
High expression of HIF-1α, BNIP3 and PI3KC3: hypoxia-induced autophagy predicts cholangiocarcinoma survival and metastasis.
Topics: Adult; Aged; Aged, 80 and over; Autophagy; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cholangiocarcinoma; Cobalt; Female; Focal Adhesion Kinase 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphatic Metastasis; Male; Membrane Proteins; Microtubule-Associated Proteins; Middle Aged; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins | 2014 |
Trigeminal pathways for hypertonic saline- and light-evoked corneal reflexes.
Topics: Anesthetics, Intravenous; Animals; Blinking; Cervical Cord; Cobalt; Cornea; Electromyography; Lidocaine; Light; Male; Muscle, Skeletal; Neural Pathways; Neurons, Afferent; Peripheral Nervous System Agents; Photic Stimulation; Rats; Saline Solution, Hypertonic; Trigeminal Nerve; Trigeminal Nuclei; Urethane; Voltage-Gated Sodium Channel Blockers | 2014 |
Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling.
Topics: Amino Acids; Animals; Apoptosis; Caspases; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cobalt; Dose-Response Relationship, Drug; Flow Cytometry; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Nerve Growth Factor; Neurons; Neuroprotective Agents; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species; Signal Transduction; Time Factors | 2014 |
δ-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxia.
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cobalt; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mammary Neoplasms, Animal; Mice; Signal Transduction; Vitamin E | 2014 |
MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells.
Topics: Adipose Tissue; Apoptosis; Base Sequence; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemokine CCL5; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Heme Oxygenase-1; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Mesenchymal Stem Cells; MicroRNAs; Molsidomine; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sequence Alignment; Transcriptome | 2014 |
Protective effect of dieckol against chemical hypoxia-induced cytotoxicity in primary cultured mouse hepatocytes.
Topics: Animals; Benzofurans; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Cyclooxygenase 2; Dose-Response Relationship, Drug; Hepatocytes; Imidazoles; Male; Mice; Mice, Inbred ICR; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Sulfonamides; Time Factors | 2015 |
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels.
Topics: Apoferritins; Cell Line, Tumor; Cobalt; Ferritins; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron-Regulatory Proteins; Protein Processing, Post-Translational; RNA, Messenger; Transcription, Genetic; Transcriptional Activation | 2014 |
Activation of hypoxia-inducible factors prevents diabetic nephropathy.
Topics: Animals; Antioxidants; Cobalt; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glomerular Filtration Rate; Hypoxia-Inducible Factor 1; Kidney; Male; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Spin Labels | 2015 |
Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Cerebral Hemorrhage; Cobalt; Disease Models, Animal; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microscopy, Confocal; Neurons; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Wharton Jelly | 2015 |
Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1α/vascular endothelial growth factor pathway.
Topics: Angiogenesis Inhibitors; Apigenin; Cell Proliferation; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Endothelial Cells; Glucose; Glucuronates; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Oxidative Stress; Reactive Oxygen Species; Retina; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2014 |
Contact sensitization to cobalt--multifactorial analysis of risk factors based on long-term data of the Information Network of Departments of Dermatology.
Topics: Adolescent; Adult; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Humans; Male; Middle Aged; Nickel; Patch Tests; Regression Analysis; Risk Factors; Time Factors; Young Adult | 2014 |
Roles of microRNA-1 in hypoxia-induced apoptotic insults to neuronal cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; DNA Fragmentation; Gene Expression Regulation; Glucose; HSP70 Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; MicroRNAs; Neurons; Oxygen; Signal Transduction; Time Factors; Transfection | 2016 |
Cobalt chloride supplementation induces stem-cell marker expression and inhibits osteoblastic differentiation in human periodontal ligament cells.
Topics: Alkaline Phosphatase; Blotting, Western; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cobalt; Flow Cytometry; Humans; Osteogenesis; Periodontal Ligament; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells | 2015 |
[Synthesis and protective effect of ligustrazine intermediates against CoCl2-induced neurotoxicity in differentiated PC12 cell].
Topics: Animals; Cell Differentiation; Chemistry Techniques, Synthetic; Cobalt; Drugs, Chinese Herbal; Neuroprotective Agents; Neurotoxins; PC12 Cells; Pyrazines; Rats | 2014 |
Tanshinone IIA pretreatment renders free flaps against hypoxic injury through activating Wnt signaling and upregulating stem cell-related biomarkers.
Topics: Abietanes; Animals; beta Catenin; Biomarkers; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cobalt; Epidermal Cells; Epidermis; Free Tissue Flaps; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred BALB C; Octamer Transcription Factor-3; Skin; SOXB1 Transcription Factors; Tissue Transplantation; Up-Regulation; Wnt Signaling Pathway | 2014 |
Cobalt chloride attenuates oxidative stress and inflammation through NF-κB inhibition in human renal proximal tubular epithelial cells.
Topics: Cell Line; Chemokine CCL2; Chemokine CCL5; Cobalt; Epithelial Cells; Heme Oxygenase-1; Humans; Inflammation; Interferon-gamma; Kidney Tubules, Proximal; NF-kappa B; NF-kappa B p50 Subunit; Oxidative Stress; Phosphorylation; Protein Binding; RNA Interference; RNA, Small Interfering; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2014 |
HGF expression induced by HIF-1α promote the proliferation and tube formation of endothelial progenitor cells.
Topics: 2-Methoxyestradiol; Animals; Cell Culture Techniques; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cobalt; Collagen; Drug Combinations; Endothelial Progenitor Cells; Estradiol; Gene Expression; Hepatocyte Growth Factor; Hypoxia-Inducible Factor 1, alpha Subunit; Laminin; Neovascularization, Pathologic; Proteoglycans; Rats; Receptors, Tachykinin | 2015 |
Association between cobalt allergy and dermatitis caused by leather articles--a questionnaire study.
Topics: Adult; Aged; Aged, 80 and over; Allergens; Case-Control Studies; Cobalt; Cross-Sectional Studies; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Humans; Male; Middle Aged; Patch Tests; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Tanning; Young Adult | 2015 |
O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models.
Topics: Animals; Cartilage, Articular; Cell Count; Cell Hypoxia; Chondrogenesis; Cobalt; Extracellular Matrix; Extremities; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-1beta; Male; Mice; Middle Aged; Models, Biological; Phenanthrolines; RNA, Messenger; SOX9 Transcription Factor; Tissue Engineering; Tumor Necrosis Factor-alpha | 2017 |
Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells.
Topics: Animals; Cell Hypoxia; Cell Nucleus; Cell Survival; Cobalt; Flavonoids; Flavonols; Free Radical Scavengers; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; PC12 Cells; Phytochemicals; Protein Kinase Inhibitors; Protein Transport; Rats; Reactive Oxygen Species; Response Elements; RNA Interference; Up-Regulation | 2015 |
Comparative effects of hypoxia and hypoxia mimetic cobalt chloride on in vitro adhesion, biofilm formation and susceptibility to amphotericin B of Candida glabrata.
Topics: Amphotericin B; Biofilms; Candida glabrata; Cell Adhesion; Cobalt; Microbial Sensitivity Tests; Oxygen | 2014 |
Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.
Topics: Animals; Aspartic Acid Endopeptidases; Cell Hypoxia; Cells, Cultured; Cobalt; Dioxygenases; Endothelin-Converting Enzymes; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Introns; Kidney Tubules, Proximal; Male; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Mice, Knockout; Mimosine; Oligonucleotide Array Sequence Analysis; Prolyl-Hydroxylase Inhibitors; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; von Hippel-Lindau Disease | 2015 |
Endocrine, biotransformation, and oxidative stress responses in salmon hepatocytes exposed to chemically induced hypoxia and perfluorooctane sulfonamide (PFOSA), given singly or in combination.
Topics: Animals; Biotransformation; Cell Hypoxia; Cobalt; Deferoxamine; Drug Interactions; Endocrine System; Fluorocarbons; Hepatocytes; Oxidative Stress; Salmon; Sulfonamides; Water Pollutants, Chemical | 2015 |
Assessment of the allergEAZE(®) patch test compared to other conventional allergens.
Topics: Allergens; Balsams; Benzothiazoles; Cobalt; Dermatitis, Allergic Contact; Humans; Mercuric Chloride; Nickel; Patch Tests; Phenylenediamines; Potassium Dichromate; Reproducibility of Results | 2015 |
A comparative immunological analysis of CoCl2 treated cells with in vitro hypoxic exposure.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD40 Antigens; Cell Hypoxia; Cell Survival; Cobalt; Interleukin-2 Receptor alpha Subunit; Interleukin-6; Lectins, C-Type; Mice; NF-kappa B; Nitric Oxide; Tumor Necrosis Factor-alpha | 2015 |
Human Adenomyosis Endometrium Stromal Cells Secreting More Nerve Growth Factor: Impact and Effect.
Topics: Adenomyosis; Adult; Apoptosis; Aromatase; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Endometrium; Enzyme Induction; Estradiol; Female; Humans; Hydrogen Peroxide; Middle Aged; Nerve Growth Factor; Stromal Cells; Tumor Necrosis Factor-alpha | 2015 |
Fibroblast growth factor and endothelin-1 receptors mediate the response of human striatal precursor cells to hypoxia.
Topics: Cell Hypoxia; Cell Proliferation; Cell Survival; Cells, Cultured; Central Nervous System Agents; Cobalt; Corpus Striatum; Dose-Response Relationship, Drug; Endothelin-1; Fetal Stem Cells; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Nerve Tissue Proteins; Neural Stem Cells; Oxidoreductases Acting on CH-CH Group Donors; Receptor, Endothelin A; Receptor, Endothelin B; Receptor, Fibroblast Growth Factor, Type 1; RNA, Messenger; Vascular Endothelial Growth Factor A | 2015 |
The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia.
Topics: Animals; Apoptosis; Caspase 12; Cell Survival; Cells, Cultured; Cinnamates; Cobalt; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Gene Knockdown Techniques; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiourea; Transcription Factor CHOP | 2015 |
Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.
Topics: Antimutagenic Agents; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Proteins; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Bombesin; Vascular Endothelial Growth Factor A | 2015 |
A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression.
Topics: Blotting, Western; Bone Morphogenetic Protein 6; Cell Line, Tumor; Cobalt; Gene Expression; Green Fluorescent Proteins; Heparin; Hepcidins; Humans; Interleukin-6; Microscopy, Fluorescence; Oncostatin M; Organic Chemicals; Promoter Regions, Genetic; Pyrazoles; Pyrimidines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Small Molecule Libraries; Triazoles | 2015 |
Study of DNA adsorption on mica surfaces using a surface force apparatus.
Topics: Adsorption; Aluminum Silicates; Cations; Cobalt; DNA; Magnesium Chloride; Surface Properties | 2015 |
The antinociceptive effect of stimulating the retrosplenial cortex in the rat tail-flick test but not in the formalin test involves the rostral anterior cingulate cortex.
Topics: Animals; Baclofen; Bicuculline; Cerebral Cortex; Cobalt; Electric Stimulation; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Gyrus Cinguli; Male; Pain Measurement; Pain Perception; Rats; Rats, Wistar; Tail | 2015 |
Zeaxanthin inhibits hypoxia-induced VEGF secretion by RPE cells through decreased protein levels of hypoxia-inducible factors-1α.
Topics: Antioxidants; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Middle Aged; Oxygen; Retinal Pigment Epithelium; RNA, Messenger; Vascular Endothelial Growth Factor A; Zeaxanthins | 2015 |
Horse welfare is the issue with use of cobalt.
Topics: Animal Welfare; Animals; Cobalt; Dietary Supplements; Horse Diseases; Horses | 2015 |
The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.
Topics: Animals; Astrocytes; Cell Hypoxia; Cell Survival; Cobalt; Colforsin; Cyclic AMP; Glucose; Neurons; Neuroprotective Agents; Oxygen; Pituitary Adenylate Cyclase-Activating Polypeptide; Primary Cell Culture; Rats; Tacrolimus; Vasoactive Intestinal Peptide | 2015 |
The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction.
Topics: Antimutagenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Kidney Tubules, Proximal; MAP Kinase Signaling System; NADPH Oxidases; Onium Compounds; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Reperfusion Injury; Up-Regulation | 2015 |
Human metabolism of orally administered radioactive cobalt chloride.
Topics: Administration, Oral; Adult; Aged; Cobalt; Cobalt Isotopes; Cobalt Radioisotopes; Female; Gastrointestinal Absorption; Humans; Male; Tissue Distribution; Young Adult | 2015 |
Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia.
Topics: Case-Control Studies; Cell Hypoxia; Cell Movement; Cells, Cultured; Cobalt; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MicroRNAs; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; RNA Splicing; Trophoblasts; Tumor Necrosis Factor Ligand Superfamily Member 15; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2015 |
The acquired radioresistance in HeLa cells under conditions mimicking hypoxia was attenuated by a decreased expression of HIF subunit genes induced by RNA interference.
Topics: Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cobalt; Gene Expression; Gene Knockdown Techniques; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Protein Subunits; Radiation Tolerance; RNA Interference; RNA, Small Interfering | 2015 |
Degradability in vitro of polyurethanes based on synthetic atactic poly[(R,S)-3-hydroxybutyrate].
Topics: 3-Hydroxybutyric Acid; Biocompatible Materials; Butylene Glycols; Calorimetry, Differential Scanning; Cobalt; Hydrogen Peroxide; Hydrolysis; Isocyanates; Microscopy; Molecular Weight; Polyesters; Polyurethanes | 2015 |
Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cells.
Topics: Apoptosis; Cell Hypoxia; Cell Line; Cell Proliferation; Chemokine CXCL12; Cobalt; Endothelial Cells; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; NF-kappa B; Receptors, CXCR4; Resveratrol; Retinal Pigment Epithelium; Signal Transduction; Stilbenes; Vascular Endothelial Growth Factor A | 2015 |
3-Aminotriazole protects from CoCl2-induced ototoxicity by inhibiting the generation of reactive oxygen species and proinflammatory cytokines in mice.
Topics: Amitrole; Animals; Catalase; Cell Line; Cobalt; Hair Cells, Auditory; Hearing Loss; Mice, Inbred BALB C; NF-kappa B; Organ Culture Techniques; Organ of Corti; Protective Agents; Rats, Sprague-Dawley; Reactive Oxygen Species; Toxicity Tests | 2016 |
Cobalt chloride induces necroptosis in human colon cancer HT-29 cells.
Topics: Antimutagenic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cobalt; Colonic Neoplasms; Humans; Microscopy, Fluorescence; Necrosis; Protein Kinases; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptor-Interacting Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2015 |
Dual targeting of the androgen receptor and hypoxia-inducible factor 1α pathways synergistically inhibits castration-resistant prostate cancer cells.
Topics: Antineoplastic Agents; Benzamides; Cell Hypoxia; Cell Line, Tumor; Cobalt; Dihydrotestosterone; Disulfides; Drug Synergism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indole Alkaloids; Male; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Transcription, Genetic | 2015 |
Decorin Prevents Retinal Pigment Epithelial Barrier Breakdown Under Diabetic Conditions by Suppressing p38 MAPK Activation.
Topics: Blood-Retinal Barrier; Blotting, Western; Cell Membrane Permeability; Cells, Cultured; Cobalt; Decorin; Dextrans; Diabetic Retinopathy; Electric Impedance; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Glucose; Humans; Hypoxia; p38 Mitogen-Activated Protein Kinases; Retinal Pigment Epithelium; RNA, Small Interfering; Tight Junction Proteins | 2015 |
Effect of air moisture content on adhesion to dentine: a comparison of dental air/water syringe tips.
Topics: Aerosols; Air; Cobalt; Dental Bonding; Dentin; Equipment Design; Humans; Humidity; Indicators and Reagents; Microscopy, Electron, Scanning; Post and Core Technique; Resin Cements; Silanes; Stress, Mechanical; Surface Properties; Syringes; Tensile Strength; Water | 2014 |
Recombinant lentivirus with enhanced expression of caudal-related homeobox protein 2 inhibits human colorectal cancer cell proliferation in vitro.
Topics: CDX2 Transcription Factor; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Colorectal Neoplasms; Genetic Vectors; Homeodomain Proteins; Humans; Lentivirus; Microscopy, Fluorescence; Promoter Regions, Genetic; Response Elements; RNA, Messenger; Telomerase | 2015 |
[Protective effect of grape seed proanthocyanidin on cultured RGC-5 cells against CoCl2-induced hypoxic injury].
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Down-Regulation; Grape Seed Extract; Proanthocyanidins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Up-Regulation | 2015 |
Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro.
Topics: Animals; Cell Line; Cell Movement; Cell Proliferation; Cell- and Tissue-Based Therapy; Chemokine CXCL10; Cobalt; Culture Media, Conditioned; Female; Fibroblasts; Gene Expression; Guided Tissue Regeneration; Horses; Interferon-gamma; Interleukin-8; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mitomycin; Models, Animal; Skin; Skin Diseases; Tumor Necrosis Factor-alpha; Wound Healing | 2015 |
Regulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury.
Topics: Analysis of Variance; Animals; Antimutagenic Agents; Apoptosis Regulatory Proteins; Beclin-1; Brain Ischemia; Cell Line; Cell Survival; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Mice; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2015 |
Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells.
Topics: Apigenin; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cell Proliferation; Cobalt; Enzyme-Linked Immunosorbent Assay; Female; G1 Phase Cell Cycle Checkpoints; Humans; Immunohistochemistry; Janus Kinase 2; Phosphorylation; Poly(ADP-ribose) Polymerases; Receptor, ErbB-2; Signal Transduction; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2015 |
Tetramethylpyrazine inhibits CoCl2 -induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways.
Topics: Animals; Apoptosis; Blotting, Western; Cell Hypoxia; Chromatin Immunoprecipitation; Cobalt; Glutamate-Cysteine Ligase; Glutathione; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neuroprotective Agents; NF-E2-Related Factor 2; PC12 Cells; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Transfection | 2015 |
3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions.
Topics: Anticarcinogenic Agents; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Humans; Hydrazones; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Macular Degeneration; Mitochondria; NF-kappa B; Nitroimidazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Transport; Reactive Oxygen Species; Retinal Pigment Epithelium; RNA Interference; RNA, Small Interfering; Vascular Endothelial Growth Factor A | 2015 |
Protein Phosphatase 1 Beta is Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration.
Topics: Cell Hypoxia; Cell Movement; Cobalt; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Pathologic; Protein Phosphatase 1; Signal Transduction; Tetralogy of Fallot; Up-Regulation | 2015 |
Toxicity and bioactivity of cobalt nanoparticles on the monocytes.
Topics: Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Humans; Monocytes; Nanoparticles; Osteoclasts; Osteolysis | 2015 |
Hypoxia-induced apoptosis is blocked by adrenomedullin via upregulation of Bcl-2 in human osteosarcoma cells.
Topics: Adrenomedullin; Apoptosis; Bone Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2 | 2015 |
Anterior gradient 2 is a binding stabilizer of hypoxia inducible factor-1α that enhances CoCl2 -induced doxorubicin resistance in breast cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cobalt; Doxorubicin; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Mucoproteins; Oncogene Proteins; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection | 2015 |
[Establishment of CoCl2 induced hypoxic cell model of oral squamous cell carcinoma and a preliminary study on the biological behaviour change].
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mouth Neoplasms; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Up-Regulation; Vascular Endothelial Growth Factor A | 2015 |
Cobalt chloride doping in racehorses: Concerns over a potentially lethal practice.
Topics: Animals; Cobalt; Doping in Sports; Enzyme Activation; Horses; Matrix Metalloproteinase 1 | 2015 |
Trophoblast expression of the minor histocompatibility antigen HA-1 is regulated by oxygen and is increased in placentas from preeclamptic women.
Topics: Adult; Cobalt; Female; Gene Expression; Humans; Minor Histocompatibility Antigens; Oligopeptides; Oxygen; Placenta; Pre-Eclampsia; Pregnancy; Trophoblasts | 2015 |
Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cation Transport Proteins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Polarity; Cobalt; Copper; Copper Transporter 1; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Fibronectins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; MCF-7 Cells; Mice; Mice, Inbred BALB C; Nuclear Proteins; Phenotype; RNA Interference; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transcriptional Activation; Transplantation, Heterologous; Triethylenephosphoramide; Twist-Related Protein 1; Vimentin | 2015 |
[The mechanism and application of hypoxia injury induced by cobalt chloride in neurons].
Topics: Cobalt; Humans; Hypoxia; Neurons | 2015 |
Attenuation of Magnesium Sulfate on CoCl₂-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1α via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cobalt; Extracellular Signal-Regulated MAP Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Magnesium Sulfate; Membrane Potential, Mitochondrial; Mice; Reactive Oxygen Species; Signal Transduction | 2015 |
The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats.
Topics: Animals; Baroreflex; Bradycardia; Central Nervous System Agents; Cobalt; Consciousness; Corticomedial Nuclear Complex; Male; Nitroprusside; Rats, Wistar; Tachycardia; Vasodilator Agents | 2015 |
RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect.
Topics: Animals; Carcinoma, Renal Cell; Cells, Cultured; Cobalt; Down-Regulation; HEK293 Cells; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Intracellular Signaling Peptides and Proteins; Kidney Neoplasms; LIM Domain Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; Proteasome Endopeptidase Complex; Protein Binding; rho GTP-Binding Proteins; RNA, Small Interfering; Transplantation, Heterologous; Von Hippel-Lindau Tumor Suppressor Protein | 2015 |
Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model.
Topics: Animals; Anticonvulsants; Cobalt; Disease Models, Animal; Drug Implants; Electrocorticography; Electromyography; Epilepsy; Motor Cortex; Polymers; Rats, Sprague-Dawley; Seizures; Temporal Muscle; Tetanus Toxin; Valproic Acid; Video Recording | 2015 |
Effect of CoCl₂ on fracture repair in a rat model of bone fracture.
Topics: Animals; Biomechanical Phenomena; Bone Remodeling; Cobalt; Disease Models, Animal; Fracture Healing; Fractures, Bone; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Osteogenesis; Rats | 2015 |
Efficient siRNA Delivery Using PEG-conjugated PAMAM Dendrimers Targeting Vascular Endothelial Growth Factor in a CoCl2-induced Neovascularization Model in Retinal Endothelial Cells.
Topics: Animals; Cells, Cultured; Cobalt; Dendrimers; Disease Models, Animal; Macaca; Neovascularization, Pathologic; Polyethylene Glycols; Retinal Vessels; RNA, Small Interfering; Vascular Endothelial Growth Factor A | 2016 |
Elucidating the Structure of Chiral Molecules by using Amplified Vibrational Circular Dichroism: From Theory to Experimental Realization.
Topics: Animals; Chlorides; Circular Dichroism; Cobalt; Coordination Complexes; Electrons; Hemoglobins; Humans; Models, Theoretical; Nickel; Stereoisomerism; Zinc Compounds | 2015 |
Curcumin inhibits cobalt chloride-induced epithelial-to-mesenchymal transition associated with interference with TGF-β/Smad signaling in hepatocytes.
Topics: Animals; Cells, Cultured; Cobalt; Curcumin; Epithelial-Mesenchymal Transition; Hepatocytes; Humans; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2015 |
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway.
Topics: Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Movement; Chloroquine; Cobalt; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Microtubule-Associated Proteins; Models, Biological; Neoplasm Invasiveness; Protein Isoforms; Proto-Oncogene Proteins; RNA, Messenger; Salivary Gland Neoplasms; Signal Transduction | 2015 |
Induction of VEGFA mRNA translation by CoCl2 mediated by HuR.
Topics: Cell Hypoxia; Cobalt; ELAV-Like Protein 1; Gene Expression Regulation; HeLa Cells; Humans; Mass Spectrometry; Protein Biosynthesis; Protein Processing, Post-Translational; Ribonucleoproteins; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Vascular Endothelial Growth Factor A | 2015 |
NcoA2-Dependent Inhibition of HIF-1α Activation Is Regulated via AhR.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Nucleus; Cobalt; Dose-Response Relationship, Drug; Gene Expression Regulation; HEK293 Cells; Hep G2 Cells; Heterografts; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Inbred ICR; Neovascularization, Physiologic; Nuclear Receptor Coactivator 2; Oxygen; Protein Binding; Receptors, Aryl Hydrocarbon; RNA Interference; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection | 2015 |
The effect and mechanism of celecoxib in hypoxia-induced survivin up-regulation in HUVECs.
Topics: Celecoxib; Cell Hypoxia; Cell Proliferation; Cobalt; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation; Genistein; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitor of Apoptosis Proteins; Survivin; Up-Regulation | 2015 |
Fucosterol protects cobalt chloride induced inflammation by the inhibition of hypoxia-inducible factor through PI3K/Akt pathway.
Topics: Cell Line; Chromones; Cobalt; Cytokines; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Keratinocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Stigmasterol | 2015 |
Genotoxicity assessment of cobalt chloride in Eisenia hortensis earthworms coelomocytes by comet assay and micronucleus test.
Topics: Animals; Chromosome Aberrations; Cobalt; Comet Assay; DNA Damage; Ecotoxicology; Leukocytes; Micronucleus Tests; Mutagens; Oligochaeta | 2016 |
SILAC-based proteomic analysis reveals that salidroside antagonizes cobalt chloride-induced hypoxic effects by restoring the tricarboxylic acid cycle in cardiomyocytes.
Topics: Adenosine Triphosphate; Apoptosis; Calcium; Caspase 3; Caspase 9; Cell Line; Chromatography, Liquid; Citric Acid Cycle; Cobalt; Computational Biology; Glucosides; Hypoxia; Membrane Potentials; Myocytes, Cardiac; Oxygen; Phenols; Plant Extracts; Proteome; Proteomics; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rhodiola; Tandem Mass Spectrometry; Tricarboxylic Acids | 2016 |
Up-Regulation of Neuronal Nitric Oxide Synthase Expression by Cobalt Chloride Through a HIF-1α Mechanism in Neuroblastoma Cells.
Topics: Cell Hypoxia; Cell Line, Tumor; Chromatin Immunoprecipitation; Cobalt; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mutagenesis, Site-Directed; Neoplasm Proteins; Neuroblastoma; Nitric Oxide; Nitric Oxide Synthase Type I; Promoter Regions, Genetic; Response Elements; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Transfection; Up-Regulation | 2015 |
Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor.
Topics: Animals; Antimutagenic Agents; Astrocytes; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cells, Cultured; Chromones; Cobalt; Culture Media, Conditioned; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione S-Transferase pi; Hypoxia-Inducible Factor 1, alpha Subunit; Leukoencephalopathies; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Myelin Basic Protein; Myelin Sheath; Phosphopyruvate Hydratase; Stem Cells | 2015 |
The mechanosensory lateral line is used to assess opponents and mediate aggressive behaviors during territorial interactions in an African cichlid fish.
Topics: Adaptation, Psychological; Aggression; Animals; Behavior, Animal; Cichlids; Cobalt; Cues; Lateral Line System; Male; Social Behavior; Territoriality | 2015 |
VEGF-mediated NF-κB activation protects PC12 cells from damage induced by hypoxia.
Topics: Animals; Cell Hypoxia; Cobalt; NF-kappa B; PC12 Cells; Rats; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Characteristics of oxygen transport through the surface of the isolated perfused rat liver.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Cardiovascular Agents; Cobalt; Computer Simulation; Diffusion; In Vitro Techniques; Liver; Male; Models, Biological; Oxygen; Oxygen Consumption; Rats, Wistar | 2015 |
The influence of ALA-mediated photodynamic therapy on secretion of selected growth factors by colon cancer cells in hypoxia-like environment in vitro.
Topics: Aminolevulinic Acid; Anaerobiosis; Apoptosis; Cell Line, Tumor; Cell Survival; Cobalt; Colonic Neoplasms; Dose-Response Relationship, Drug; Fibroblast Growth Factors; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypoxia; Intercellular Signaling Peptides and Proteins; Photochemotherapy; Photosensitizing Agents | 2015 |
Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts.
Topics: Arthritis, Rheumatoid; Cell Hypoxia; Chemokines; Cobalt; Fibroblasts; Humans; Lysophospholipids; Membrane Proteins; Phosphoric Monoester Hydrolases; Signal Transduction; Sphingosine; Stress, Physiological; Synovial Membrane; Thiazolidines | 2015 |
CA IX is upregulated in CoCl2-induced hypoxia and associated with cell invasive potential and a poor prognosis of breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers, Tumor; Breast Neoplasms; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Proliferation; Cobalt; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Middle Aged; Prognosis; Transcriptional Activation | 2016 |
Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1α-VEGF pathway.
Topics: Apoptosis; Cell Hypoxia; Cell Survival; Cobalt; Drugs, Chinese Herbal; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Pyrazines; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Involvement of aberrant calcium signalling in herpetic neuralgia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Carbenoxolone; Cell Communication; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Female; Green Fluorescent Proteins; Male; Mice; Mice, Inbred BALB C; Neuroglia; Neurons; Simplexvirus; Trigeminal Ganglion; Virus Activation | 2016 |
α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways.
Topics: Cadherins; Cell Line, Tumor; Cobalt; Coculture Techniques; Down-Regulation; Humans; Hypoxia-Inducible Factor 1; MAP Kinase Signaling System; Pancreatic Neoplasms; Signal Transduction; Solanine; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2016 |
Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.
Topics: Animals; Cell Differentiation; Cobalt; Disease Models, Animal; Haplorhini; Human Embryonic Stem Cells; Humans; Photoreceptor Cells; Primates; Rats; Retina; Retinal Degeneration | 2016 |
The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer.
Topics: Adult; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cobalt; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Giant Cells; Humans; Lymphatic Metastasis; MCF-7 Cells; Middle Aged; Neoplasm Invasiveness; Polyploidy; Vimentin | 2015 |
NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.
Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Cell Hypoxia; Cell Line; Cobalt; Cytoskeletal Proteins; Early Growth Response Protein 1; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipoproteins; NF-kappa B; Oxygen; Phalloidine; Podocytes; Pyrrolidines; RNA Interference; RNA, Messenger; Signal Transduction; Thiocarbamates; Thromboplastin; Time Factors; Transfection; Up-Regulation | 2016 |
Stimulation of the hypoxia pathway modulates chemotherapy resistance in Hodgkin's lymphoma cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Cobalt; Drug Resistance, Neoplasm; Flow Cytometry; Hodgkin Disease; Humans; Hypoxia | 2016 |
Extracellular stress stimuli alter galectin expression profiles and adhesion characteristics of HL-60 cells.
Topics: Cell Adhesion; Cell Differentiation; Cell Hypoxia; Cell Size; Cobalt; Endoplasmic Reticulum Stress; Galectins; Gene Expression Regulation; HL-60 Cells; Humans; Tunicamycin | 2016 |
Quinolinic acid induces cell apoptosis in PC12 cells through HIF-1-dependent RTP801 activation.
Topics: Animals; Apoptosis; Cell Hypoxia; Cobalt; Hypoxia-Inducible Factor 1, alpha Subunit; PC12 Cells; Quinolinic Acid; Rats; Reactive Oxygen Species; Repressor Proteins; Transcription Factors; Up-Regulation | 2016 |
Exposure pattern influences the degree of drug-seeking behaviour after withdrawal.
Topics: Animals; Cobalt; Conditioning, Operant; Drug-Seeking Behavior; Hippocampus; Injections, Intravenous; Male; Morphine; Random Allocation; Rats; Rats, Sprague-Dawley; Self Administration; Substance Withdrawal Syndrome | 2016 |
All-Trans Retinoic Acid Attenuates Hypoxia-Induced Injury in NRK52E Cells via Inhibiting NF-x03BA;B/VEGF and TGF-β2/VEGF Pathway.
Topics: Animals; Antineoplastic Agents; Cathepsin A; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Immunoprecipitation; NF-kappa B; Protein Binding; Rats; Signal Transduction; Transcription Factor RelA; Transforming Growth Factor beta2; Tretinoin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor B | 2016 |
Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells.
Topics: Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Humans; Hydrogen Peroxide; Macular Degeneration; Oxidative Stress; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Retinal Pigment Epithelium; Signal Transduction; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2016 |
Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell.
Topics: Cell Hypoxia; Cell Line; Cell Nucleus; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Phosphorylation; Protein Kinase C-alpha | 2016 |
Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model.
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Cysteine; Flow Cytometry; Formazans; Garlic; PC12 Cells; Plant Extracts; Rats; Reactive Oxygen Species; Tetrazolium Salts | 2016 |
Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways.
Topics: Apoptosis; Bronchi; Cell Line; Cell Proliferation; Cobalt; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; Epithelial Cells; Histones; Humans; Inhalation Exposure; Metal Nanoparticles; Micronuclei, Chromosome-Defective; Micronucleus Tests; Oxides; Risk Assessment; Solubility | 2016 |
The hypoxia-mimetic agent CoCl₂ induces chemotherapy resistance in LOVO colorectal cancer cells.
Topics: bcl-2-Associated X Protein; bcl-Associated Death Protein; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Colorectal Neoplasms; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Humans; Real-Time Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles | 2016 |
Time-dependent homeostasis between glucose uptake and consumption in astrocytes exposed to CoCl₂ treatment.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Glycogen; Homeostasis; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Inbred BALB C; Pyruvic Acid; Stroke | 2016 |
Up-Regulation of ENO1 by HIF-1α in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion.
Topics: Biomarkers, Tumor; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate Dehydrogenase; Oxygen; Phosphopyruvate Hydratase; Retinal Pigment Epithelium; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2016 |
Revisiting cobalt chloride preconditioning to prevent hypobaric hypoxia-induced damage: identification of global proteomic alteration and key networks.
Topics: Animals; Cell Cycle; Cobalt; Gene Expression Regulation; Hypoxia; Lipid Metabolism; Proteomics; Rats; Reactive Oxygen Species | 2016 |
A Mn(II) complex of boradiazaindacene (BODIPY) loaded graphene oxide as both LED light and H2O2 enhanced anticancer agent.
Topics: Antineoplastic Agents; Boron Compounds; Cobalt; Drug Screening Assays, Antitumor; Graphite; Hep G2 Cells; Humans; Hydrogen Peroxide; Light | 2016 |
Using Group II Introns for Attenuating the In Vitro and In Vivo Expression of a Homing Endonuclease.
Topics: Chaetomium; Cobalt; Deoxyribonucleases, Type II Site-Specific; Fungal Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Introns; Recombinant Proteins | 2016 |
Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis.
Topics: Animal Fins; Animals; Animals, Genetically Modified; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Hypoxia; Cobalt; Hypoxia-Inducible Factor 1; Neovascularization, Physiologic; Regeneration; Signal Transduction; Zebrafish | 2016 |
Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage.
Topics: Animals; Bradycardia; Cobalt; Disease Models, Animal; Hemorrhage; Hemostatics; Hypothalamus; Hypovolemia; Lidocaine; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley | 2016 |
Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1α is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Chemoembolization, Therapeutic; Cobalt; Cyclooxygenase 2; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Middle Aged; Prognosis | 2016 |
Cobalt allergy: suitable test concentration, and concomitant reactivity to nickel and chromium.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Caustics; Child; Chromium; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Irritants; Male; Middle Aged; Nickel; Patch Tests; Potassium Dichromate; Young Adult | 2016 |
Sex differences in hypothalamic-mediated tonic norepinephrine release for thermal hyperalgesia in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cobalt; Constriction, Pathologic; Dioxanes; Disease Models, Animal; Female; Hot Temperature; Hyperalgesia; Hypothalamus; Male; Neuralgia; Nociceptive Pain; Norepinephrine; Random Allocation; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Sciatic Nerve; Sex Characteristics; Yohimbine | 2016 |
NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cobalt; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hippocampus; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Swimming | 2016 |
Differential involvement of glutamatergic and catecholaminergic activity within the amygdala during taste aversion retrieval on memory expression and updating.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Avoidance Learning; Catecholamines; Cobalt; Conditioning, Psychological; Excitatory Amino Acid Agents; Exploratory Behavior; Glutamic Acid; Immobility Response, Tonic; Male; Mental Recall; Microdialysis; N-Methylaspartate; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Swimming; Taste | 2016 |
Time-dependent activity of Na+/H+ exchanger isoform 1 and homeostasis of intracellular pH in astrocytes exposed to CoCl2 treatment.
Topics: Animals; Astrocytes; Cation Transport Proteins; Cell Hypoxia; Cell Line; Cobalt; Gene Expression Regulation; Homeostasis; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Protein Isoforms; RNA, Messenger; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers | 2016 |
Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cobalt; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; NIH 3T3 Cells; Nuclear Proteins; Trans-Activators; Transcription Factors; Up-Regulation; X-Linked Inhibitor of Apoptosis Protein | 2016 |
The cytotoxicity and genotoxicity of soluble and particulate cobalt in human lung epithelial cells.
Topics: Cell Line; Chromosome Aberrations; Cobalt; Cytotoxins; DNA Damage; Epithelial Cells; Humans; Lung; Mutagens; Oxides; Particle Size; Solubility | 2016 |
Interactions of Some Divalent Metal Ions with Thymine and Uracil Thiosemicarbazide Derivatives.
Topics: Cobalt; Coordination Complexes; Copper; Hydrogen-Ion Concentration; Semicarbazides; Thermodynamics; Thymine; Uracil | 2016 |
High homocysteine levels prevent via H2 S the CoCl2 -induced alteration of lymphocyte viability.
Topics: Adenosine; Adult; Alkynes; Cell Hypoxia; Cell Survival; Cobalt; Glycine; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Lymphocytes; Middle Aged; Models, Biological; Signal Transduction | 2016 |
Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cobalt; Disease Models, Animal; Female; Fungal Proteins; Gene Expression Regulation, Fungal; Host-Pathogen Interactions; Hypoxia; Immunocompromised Host; Larva; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Moths; Mutation; Neurospora crassa; Peptide Hydrolases; Signal Transduction; Spores, Fungal; Sterol Regulatory Element Binding Proteins; Ubiquitin-Protein Ligases; Virulence | 2016 |
Functional lateralization of the medial prefrontal cortex in the modulation of anxiety in mice: Left or right?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cobalt; Dose-Response Relationship, Drug; Functional Laterality; Injections, Intraventricular; Male; Mice; Nitric Oxide; Prefrontal Cortex; Triazenes | 2016 |
Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells.
Topics: Antipyrine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line; Cobalt; Edaravone; Humans; Matrix Metalloproteinase 2; Reactive Oxygen Species; Tissue Inhibitor of Metalloproteinase-2; Trophoblasts | 2016 |
An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells.
Topics: A549 Cells; Acetylation; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Hypoxia-Inducible Factor 1, alpha Subunit; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MCF-7 Cells; Phorbol Esters; Poly(ADP-ribose) Polymerases; Sulfonamides; Tubulin; Tumor Suppressor Protein p53 | 2016 |
Bosentan reverses the hypoxia-induced downregulation of the bone morphogenetic protein signaling in pulmonary artery smooth muscle cells.
Topics: Bone Morphogenetic Proteins; Bosentan; Cells, Cultured; Cobalt; Down-Regulation; Endothelin Receptor Antagonists; Humans; Hypoxia; Muscle, Smooth, Vascular; Pulmonary Artery; Signal Transduction; Sulfonamides | 2016 |
STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer.
Topics: Animals; Cadherins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Cobalt; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; STAT3 Transcription Factor; Transplantation, Heterologous; Vimentin | 2016 |
Light-Emitting Diode Irradiation (640 nm) Regulates Keratinocyte Migration and Cytoskeletal Reorganization Via Hypoxia-Inducible Factor-1α.
Topics: Adult; Blotting, Western; Cell Movement; Cell Proliferation; Child; Cobalt; Cytoskeleton; Foreskin; Glycine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Keratinocytes; Low-Level Light Therapy; Male; Up-Regulation | 2016 |
Alterations in blood pressure, antioxidant status and caspase 8 expression in cobalt chloride-induced cardio-renal dysfunction are reversed by Ocimum gratissimum and gallic acid in Wistar rats.
Topics: Animals; Antioxidants; Blood Pressure; Cardio-Renal Syndrome; Caspase 8; Cobalt; Gallic Acid; Male; Ocimum; Plant Extracts; Rats; Rats, Wistar | 2016 |
Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model.
Topics: Animals; Ascorbic Acid; Cobalt; Gene Expression Regulation; Hypertension; Male; NF-kappa B; Oxidative Stress; Quercetin; Rats; Rats, Wistar | 2017 |
Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.
Topics: Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Diterpenes; Endothelial Cells; Endothelin-1; Heme Oxygenase-1; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Prolyl Hydroxylases; Reactive Oxygen Species; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2017 |
Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2.
Topics: Animals; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Extracellular Signal-Regulated MAP Kinases; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Up-Regulation; Ursodeoxycholic Acid | 2016 |
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Topics: Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cobalt; Female; Glucose; Glucose Transporter Type 1; Hexokinase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; MCF-7 Cells; RNA, Messenger | 2017 |
Cyclosporin A Protects H9c2 Cells Against Chemical Hypoxia-Induced Injury via Inhibition of MAPK Signaling Pathway.
Topics: Animals; Apoptosis; Cells, Cultured; Cobalt; Cyclosporine; Hypoxia; Immunosuppressive Agents; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Oxidative Stress; Rats | 2016 |
The reproducibility of nickel, cobalt and chromate sensitization in patients tested at least twice in the period 1992-2014 with TRUE Test®.
Topics: Caustics; Cobalt; Dermatitis, Allergic Contact; Humans; Irritants; Nickel; Patch Tests; Potassium Dichromate; Reproducibility of Results; Retrospective Studies | 2016 |
Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase.
Topics: Adipose Tissue; Adult; Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Female; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Humans; Hydrogen Peroxide; Luminescent Measurements; Mice; Middle Aged; Reactive Oxygen Species; Stromal Cells; Superoxide Dismutase | 2016 |
Cobalt Chloride Treatment Used to Ablate the Lateral Line System Also Impairs the Olfactory System in Three Freshwater Fishes.
Topics: Animals; Characidae; Cichlids; Cobalt; Female; Fishes; Goldfish; Lateral Line System; Male; Mechanoreceptors; Smell | 2016 |
Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis.
Topics: Atractylodes; Blotting, Western; Chorioallantoic Membrane; Cobalt; Down-Regulation; Enediynes; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
Topics: Animals; Cell Cycle Proteins; Cell Death; Cobalt; DNA Damage; Doxorubicin; Heart Failure; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Receptors, Glucocorticoid; Repressor Proteins; Response Elements; Signal Transduction | 2016 |
Effect of leptin combined with CoCl2 on healing in Sprague Dawley Rat fracture model.
Topics: Animals; Cobalt; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Drug Therapy, Combination; Femoral Fractures; Fracture Healing; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Intraperitoneal; Leptin; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome; Up-Regulation; Vascular Endothelial Growth Factor A | 2016 |
Role of vincristine in the inhibition of angiogenesis in glioblastoma.
Topics: Antineoplastic Agents, Phytogenic; Cell Hypoxia; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Pathologic; RNA, Messenger; Vascular Endothelial Growth Factor A; Vincristine | 2016 |
Endocannabinoids participate in placental apoptosis induced by hypoxia inducible factor-1.
Topics: Apoptosis; Caspase 3; Cell Hypoxia; Cell Survival; Cobalt; Endocannabinoids; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Placenta; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2016 |
Tissue factor induces VEGF expression via activation of the Wnt/β-catenin signaling pathway in ARPE-19 cells.
Topics: Animals; beta Catenin; Blotting, Western; Cell Count; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; Enzyme-Linked Immunosorbent Assay; Glycogen Synthase Kinase 3 beta; Humans; Macaca mulatta; Plasmids; Retinal Pigment Epithelium; Thromboplastin; Transfection; Vascular Endothelial Growth Factor A; Wnt Signaling Pathway | 2016 |
Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway.
Topics: beta-Lactamases; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Genes, Reporter; HCT116 Cells; High-Throughput Screening Assays; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Signal Transduction; Small Molecule Libraries; Topotecan | 2016 |
Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury.
Topics: Animals; Apoptosis; Cell Hypoxia; Cobalt; Cytoprotection; Epithelial Cells; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Kidney; Mice; Mimosine; Prolyl-Hydroxylase Inhibitors; Reperfusion Injury | 2016 |
Protective effects of kolaviron and gallic acid against cobalt-chloride-induced cardiorenal dysfunction via suppression of oxidative stress and activation of the ERK signaling pathway.
Topics: Acute Kidney Injury; Animals; Antioxidants; Cobalt; Drug Therapy, Combination; Flavonoids; Gallic Acid; Garcinia kola; Heart Diseases; Male; MAP Kinase Signaling System; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Seeds | 2016 |
Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis.
Topics: Alkaline Phosphatase; Angiogenesis Inducing Agents; Animals; Bone Density; Cell Hypoxia; Cell Line; Cobalt; Female; Glucosides; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Osteoblasts; Osteoporosis; Ovariectomy; Phenols; Protective Agents; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction | 2016 |
Hypoxia-Induced MicroRNA-429 Promotes Differentiation of MC3T3-E1 Osteoblastic Cells by Mediating ZFPM2 Expression.
Topics: Alkaline Phosphatase; Animals; Cell Differentiation; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; DNA-Binding Proteins; Femoral Neck Fractures; Femur; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; HEK293 Cells; Humans; Lentivirus; Luciferases; Mice; MicroRNAs; Models, Biological; Osteoblasts; Osteogenesis; Signal Transduction; Transcription Factors; Transcription, Genetic | 2016 |
Mechanical stretch and hypoxia inducible factor-1 alpha affect the vascular endothelial growth factor and the connective tissue growth factor in cultured ACL fibroblasts.
Topics: Adult; Anterior Cruciate Ligament; Cells, Cultured; Cobalt; Connective Tissue Growth Factor; Female; Fibroblasts; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Matrix Metalloproteinase 2; Middle Aged; Stress, Mechanical; Vascular Endothelial Growth Factor A | 2017 |
The significance of the increased expression of phosphorylated MeCP2 in the membranes from patients with proliferative diabetic retinopathy.
Topics: Adult; Aged; Cell Line; Cobalt; Diabetic Retinopathy; Epiretinal Membrane; Eye Proteins; Female; Humans; Male; Methyl-CpG-Binding Protein 2; Middle Aged; Nerve Growth Factors; Phosphorylation; Serine; Serpins; Up-Regulation; Vascular Endothelial Growth Factor A; Young Adult | 2016 |
Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines.
Topics: Apoptosis; Carcinogenesis; Cell Adhesion; Cell Movement; Cell Proliferation; Cobalt; Extracellular Vesicles; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; RNA Interference; RNA, Long Noncoding; RNA, Small Interfering; Spheroids, Cellular; Transforming Growth Factor beta; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2017 |
Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells.
Topics: Blood-Brain Barrier; Capillary Permeability; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Electric Impedance; Endothelial Cells; Fluorescein; Fluorescent Dyes; Glucose; Humans; Hypoxia-Ischemia, Brain; Immunohistochemistry; Microvessels; Stem Cells; Tight Junctions | 2016 |
Participation of HIFs in the regulation of Sertoli cell lactate production.
Topics: Acetanilides; Adamantane; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Blotting, Northern; Blotting, Western; Carrier Proteins; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Gene Expression Regulation; Glucose Transporter Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lactates; Male; Membrane Proteins; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Time Factors | 2017 |
Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation.
Topics: Antineoplastic Agents; Cell Movement; Cobalt; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Quercetin; Reactive Oxygen Species | 2016 |
Hippocampal subareas arranged in the dorsoventral axis modulate cardiac baroreflex function in a site-dependent manner in rats.
Topics: Animals; Baroreflex; Blood Pressure; Cobalt; Heart; Heart Rate; Hippocampus; Male; Rats; Rats, Wistar; Synaptic Transmission | 2017 |
HIF Stabilization Weakens Primary Cilia.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biomechanical Phenomena; Cilia; Cobalt; Dogs; Madin Darby Canine Kidney Cells; Mechanical Phenomena; Paclitaxel; Protein Stability | 2016 |
Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Cobalt; Docetaxel; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Everolimus; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Inbred BALB C; Mice, Nude; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; RNA Interference; Signal Transduction; Taxoids; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Impact of hypoxia inducible factors on estrogen receptor expression in breast cancer cells.
Topics: Breast Neoplasms; Cobalt; Disease Progression; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Oxygen | 2017 |
Inhibition of histone/lysine acetyltransferase activity kills CoCl
Topics: Acetylation; Antineoplastic Agents; Apoptosis; Cell Line, Transformed; Cell Line, Tumor; Cobalt; Curcumin; E1A-Associated p300 Protein; Enzyme Inhibitors; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Hydrogen Peroxide; MAP Kinase Signaling System; Neoplasm Invasiveness; Oxidative Stress; Reactive Oxygen Species; Solubility; Stomach Neoplasms; Tumor Hypoxia | 2017 |
CoCl
Topics: Acetylation; Animals; Chlorocebus aethiops; Cobalt; COS Cells; Epigenesis, Genetic; Flavonoids; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hypoxia; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Superoxide Dismutase | 2016 |
Time trends of contact allergy to the European baseline series in Lithuania.
Topics: Age Factors; Allergens; Cobalt; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Formaldehyde; Hand Dermatoses; Humans; Leg Dermatoses; Lithuania; Male; Myroxylon; Nickel; Nitriles; Patch Tests; Perfume; Phenylenediamines; Population Surveillance; Potassium Dichromate; Prevalence; Resins, Plant; Retrospective Studies; Sex Factors; Thiazoles | 2017 |
Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells.
Topics: Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Line, Transformed; Cobalt; Lutein; Rats; Retina | 2016 |
Relationship between RSUME and HIF-1α/VEGF-A with invasion of pituitary adenoma.
Topics: Adenoma; Adult; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Middle Aged; Models, Biological; Neoplasm Invasiveness; Pituitary Neoplasms; RNA, Small Interfering; Signal Transduction; Transcription Factors; Vascular Endothelial Growth Factor A | 2017 |
Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line; Cobalt; Diabetic Retinopathy; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Glucosides; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Indazoles; Ligustrum; Plant Extracts; Pyrans; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Pigment Epithelium; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Cobalt Chloride Induces Expression and Function of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Renal Proximal Tubular Epithelial Cell Line HK-2.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line; Cell Survival; Cobalt; Epithelial Cells; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Methotrexate; Mitoxantrone; Neoplasm Proteins; RNA, Messenger | 2017 |
Cinnamaldehyde induces apoptosis and reverses epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in non-small cell lung cancer.
Topics: A549 Cells; Acrolein; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cobalt; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2017 |
HDAC6 regulates sensitivity to cell death in response to stress and post-stress recovery.
Topics: Animals; Apoptosis; Arsenites; Cell Hypoxia; Cell Line; Cobalt; Gamma Rays; Gene Knockout Techniques; Histone Deacetylase 6; Histone Deacetylases; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mutagenesis; Oxidative Stress; Temperature; Transcriptional Activation | 2017 |
Experimental patch testing with chromium-coated materials.
Topics: Adult; Aged; Case-Control Studies; Chromium; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Nickel; Patch Tests; Potassium Dichromate | 2017 |
Discordant mRNA and protein expression of CXCR4 under in vitro CoCl
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cobalt; Human Umbilical Vein Endothelial Cells; Humans; Rats; Receptors, CXCR4; Retinal Diseases; RNA, Messenger; Up-Regulation | 2017 |
Requirement of Hsp105 in CoCl
Topics: Active Transport, Cell Nucleus; Cell Hypoxia; Cell Nucleus; Cobalt; Heat-Shock Response; HEK293 Cells; HeLa Cells; HSP110 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Protein Binding; Response Elements; Transcriptional Activation | 2017 |
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway.
Topics: Adenine; Antimutagenic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Cobalt; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirolimus; Tumor Suppressor Protein p53 | 2017 |
Emergence and development of gut motility in the chicken embryo.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Movement; Chick Embryo; Cobalt; Disease Models, Animal; Hirschsprung Disease; Intestines; Muscle, Smooth; Myenteric Plexus; Neural Crest; Organ Culture Techniques; Peristalsis; Tetrodotoxin; Time-Lapse Imaging | 2017 |
Cobalt(II) Chloride Modifies the Phenotype of Macrophage Activation.
Topics: Animals; Arginase; Biomarkers; Cell Line; Cobalt; Gene Expression Profiling; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Immunomodulation; Interleukin-6; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; NADPH Oxidase 2; Nitric Oxide; Nitric Oxide Synthase Type II; Osmolar Concentration; Trace Elements | 2017 |
Cobalt Chloride-induced Hypoxia Induces Epithelial-mesenchymal Transition in Renal Carcinoma Cell Lines.
Topics: Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Cobalt; Epithelial-Mesenchymal Transition; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Neoplasms | 2017 |
The role of ZFP580, a novel zinc finger protein, in TGF-mediated cytoprotection against chemical hypoxia‑induced apoptosis in H9c2 cardiac myocytes.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Cytoprotection; Hypoxia-Inducible Factor 1, alpha Subunit; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Rats; Reactive Oxygen Species; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad2 Protein; Smad3 Protein; Transcription Factors; Transforming Growth Factor beta1 | 2017 |
Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride.
Topics: Animals; Behavior, Animal; Cobalt; Disease Models, Animal; Female; Formaldehyde; Male; Organometallic Compounds; Pain; Pain Perception; Rats, Wistar; Reaction Time; Time Factors | 2017 |
Chemically induced hypoxia promotes differential outcomes over preadipocyte- or adipocyte-macrophage communication.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Communication; Cell Differentiation; Cell Hypoxia; Cell Line; Cell Survival; Chemokine CCL2; Cobalt; Culture Media, Conditioned; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-1; Interleukin-6; Macrophages; Mice; Nitric Oxide; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Down-regulation of the placental BCRP/ABCG2 transporter in response to hypoxia signaling.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cobalt; Down-Regulation; Female; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Proteins; Placenta; Pregnancy; Signal Transduction; Vascular Endothelial Growth Factor A | 2017 |
Interlaboratory trial for the measurement of total cobalt in equine urine and plasma by ICP-MS.
Topics: Animals; Body Fluids; Cobalt; Dietary Supplements; Horses; Mass Spectrometry; Plasma; Reproducibility of Results | 2017 |
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.
Topics: Cell Line, Tumor; Cobalt; Fibroblasts; Gene Expression Regulation; Gene Knockout Techniques; Gene Silencing; Genetic Loci; Humans; Hypoxia; Neoplasms; Promyelocytic Leukemia Protein; Protein Binding; Protein Biosynthesis; Radiation, Ionizing; TOR Serine-Threonine Kinases; Transcription Factors; Transcription, Genetic | 2017 |
Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts.
Topics: Adolescent; Adult; Blotting, Western; Calcitriol; Case-Control Studies; Caspase 3; Caveolin 1; Cell-Derived Microparticles; Cobalt; Female; Humans; Nitric Oxide Synthase Type III; Oxidative Stress; Pre-Eclampsia; Pregnancy; rho-Associated Kinases; Trophoblasts; Vitamins; Young Adult | 2017 |
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
Topics: Animals; Animals, Newborn; Butadienes; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; Cobalt; Diabetic Retinopathy; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Neovascularization, Pathologic; Nitriles; Proto-Oncogene Proteins c-fos; Rats; Receptors, G-Protein-Coupled; Retina; Vascular Endothelial Growth Factor A | 2017 |
A non-toxic dose of cobalt chloride blocks hair cells of the zebrafish lateral line.
Topics: Animals; Calcium Signaling; Cobalt; Dose-Response Relationship, Drug; Evoked Potentials; Hair Cells, Auditory; Larva; Lateral Line System; Mechanotransduction, Cellular; Time Factors; Zebrafish | 2017 |
The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance.
Topics: Animals; Animals, Genetically Modified; Calcification, Physiologic; Calcitriol; Cobalt; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Genetic Markers; Larva; Male; Osteoblasts; Osteogenesis; Skull; Toxicity Tests; Zebrafish | 2017 |
The effect of ALA-PDT under normoxia and cobalt chloride (CoCl
Topics: Aminolevulinic Acid; Apoptosis; Cell Adhesion Molecules; Cell Count; Cell Line, Tumor; Cell Survival; Cobalt; Colorectal Neoplasms; Disease Progression; Humans; Hypoxia; Intercellular Adhesion Molecule-1; Photochemotherapy; Photosensitizing Agents; Vascular Cell Adhesion Molecule-1 | 2017 |
Kv3.4 is modulated by HIF-1α to protect SH-SY5Y cells against oxidative stress-induced neural cell death.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neurons; Oxidative Stress; Potassium Channel Blockers; Shaw Potassium Channels | 2017 |
Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Cations, Divalent; Cell Hypoxia; Cell Line; Cobalt; Drug Evaluation, Preclinical; Intracellular Space; Janus Kinase 1; Mice; Microglia; Neuroimmunomodulation; Neuroprotective Agents; Phosphorylation; Propofol; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2017 |
The up regulation of phosphofructokinase1 (PFK1) protein during chemically induced hypoxia is mediated by the hypoxia-responsive internal ribosome entry site (IRES) element, present in its 5'untranslated region.
Topics: 5' Untranslated Regions; Animals; Base Sequence; Blotting, Western; Cobalt; Fructosephosphates; Glioma; Hypoxia; Internal Ribosome Entry Sites; Phosphofructokinase-1; Polypyrimidine Tract-Binding Protein; Promoter Regions, Genetic; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 2017 |
Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle.
Topics: Cell Line, Tumor; Cobalt; Deferoxamine; Embolization, Therapeutic; Gadolinium; Humans; Nanoparticles; Neoplasms; Radiation-Sensitizing Agents; Titanium; Tumor Hypoxia | 2017 |
[EVALUATION OF GENOMIC PARAMETERS IN DUCTAL BREAST CANCER PATIENTS AND THE ABILITY OF IT'S CORRECTION].
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cells, Cultured; Chromosome Aberrations; Cobalt; DNA Breaks, Single-Stranded; Female; Humans; Lymphocytes; Oligopeptides; Sister Chromatid Exchange | 2017 |
In vitro oxidative degradation of a spinal posterior dynamic stabilization device.
Topics: Biocompatible Materials; Cobalt; Elasticity; Internal Fixators; Materials Testing; Oxidation-Reduction; Polycarboxylate Cement; Silicones; Spectroscopy, Fourier Transform Infrared; Spine; Surface Properties; Urethane; Viscosity | 2018 |
Enhancement of the antiproliferative activity of [RuCp(PPh
Topics: A549 Cells; Antineoplastic Agents; Cell Proliferation; Chloroform; Cobalt; Coordination Complexes; Crystallography, X-Ray; Culture Media; Dimethyl Sulfoxide; HeLa Cells; Humans; Molecular Structure; Nitrogen; Ruthenium; Temperature; Water | 2017 |
Folic acid attenuates cobalt chloride-induced PGE
Topics: Anti-Inflammatory Agents; Cell Hypoxia; Cobalt; Cyclooxygenase 2; Dinoprostone; Folic Acid; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Nitric Oxide; Signal Transduction; Vitamin B Complex | 2017 |
mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.
Topics: Age Factors; Animals; Caenorhabditis elegans Proteins; Carboxylic Ester Hydrolases; Cell Hypoxia; Cells, Cultured; Cobalt; Fatty Acid Desaturases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; NF-E2-Related Factor 2; Signal Transduction; Transgenes | 2018 |
Effects of Cobalt Chloride, a Hypoxia-Mimetic Agent, on Autophagy and Atrophy in Skeletal C2C12 Myotubes.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Atrophy; Autophagy; Cell Hypoxia; Cobalt; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Muscle Fibers, Skeletal; Muscle, Skeletal; Myogenin; TOR Serine-Threonine Kinases | 2017 |
Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture.
Topics: Breast Neoplasms; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Neoplastic Stem Cells; Receptor, ErbB-2; Spheroids, Cellular; Trastuzumab | 2018 |
Hydralazine is a Suitable Mimetic Agent of Hypoxia to Study the Impact of Hypoxic Stress on In Vitro Blood-Brain Barrier Model.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Cell Hypoxia; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Cobalt; Coculture Techniques; Endothelial Cells; Fluorescein; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Hydralazine; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Models, Biological; Neuroglia; Occludin; Permeability; Rats; Zonula Occludens-1 Protein | 2017 |
Astaxanthin mitigates cobalt cytotoxicity in the MG-63 cells by modulating the oxidative stress.
Topics: Apoptosis; Cell Line, Tumor; Cobalt; Heme Oxygenase-1; Humans; MAP Kinase Kinase 4; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Xanthophylls | 2017 |
Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness.
Topics: Animals; Cell Enlargement; Cell Line; Cell Survival; Cobalt; Edema, Cardiac; Elasticity; Histone Deacetylase 1; Hypoxia; Myocytes, Cardiac; Protective Agents; Rats | 2017 |
Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells.
Topics: Animals; Autophagy; Beclin-1; Cell Hypoxia; Cell Proliferation; Chloroquine; Cobalt; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Developmental; Granulosa Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibins; Membrane Proteins; Mice; Mice, Inbred ICR; Mitochondrial Proteins; Morpholines; Multienzyme Complexes; Primary Cell Culture; Progesterone Reductase; Protein Kinases; RNA, Small Interfering; Signal Transduction; Steroid Isomerases; TOR Serine-Threonine Kinases; Triazines; Ubiquitin-Protein Ligases | 2017 |
E2f1 mediates high glucose-induced neuronal death in cultured mouse retinal explants.
Topics: Animals; Blood Vessels; Cell Cycle; Cell Death; Cell Hypoxia; Cobalt; E2F1 Transcription Factor; Ependymoglial Cells; Gene Expression; Glucose; Humans; Mice; Models, Biological; Retina; Tissue Culture Techniques | 2017 |
Biological events and molecular signaling following MLKL activation during necroptosis.
Topics: Animals; Apoptosis; Calcium; Cell Hypoxia; Cell Membrane; Cobalt; Endosomal Sorting Complexes Required for Transport; Fibroblasts; Gene Expression Regulation; HT29 Cells; Humans; Macrophages; Mice; Models, Biological; Necrosis; NIH 3T3 Cells; Phosphatidylserines; Phosphorylation; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction | 2017 |
Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity.
Topics: Animals; Cell Differentiation; Cell Hypoxia; Cell Survival; Cobalt; Drug Stability; Flowers; Glucosides; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Light; Neurons; Oleaceae; PC12 Cells; Phenols; Plant Extracts; Protective Agents; Rats | 2017 |
Nitric oxide is essential for the development of aerenchyma in wheat roots under hypoxic stress.
Topics: Benzoates; Cobalt; Ethylenes; Imidazoles; Nitrate Reductase; Nitric Oxide; Nitrites; Oxygen; Plant Growth Regulators; Plant Proteins; Plant Roots; Reactive Oxygen Species; Signal Transduction; Stress, Physiological; Triticum | 2017 |
Tanshinone IIA Inhibits VEGF Secretion and HIF-1α Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia.
Topics: Abietanes; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A | 2017 |
Functional characterization of the Dsc E3 ligase complex in the citrus postharvest pathogen Penicillium digitatum.
Topics: Citrus; Cobalt; DNA, Fungal; Drug Resistance, Fungal; Ergosterol; Fungal Proteins; Fungicides, Industrial; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal; Microbial Sensitivity Tests; Mutation; Mycelium; Penicillium; Plant Diseases; Sterol Regulatory Element Binding Proteins; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases; Virulence | 2017 |
High mobility group B1 up-regulates angiogenic and fibrogenic factors in human retinal pigment epithelial ARPE-19 cells.
Topics: Angiogenesis Inducing Agents; Autocrine Communication; Cell Hypoxia; Cell Proliferation; Cobalt; Diabetic Retinopathy; Gene Expression Regulation, Developmental; HMGB1 Protein; Humans; p38 Mitogen-Activated Protein Kinases; Peptides; Retinal Pigment Epithelium; Signal Transduction | 2017 |
Ursodeoxycholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein.
Topics: Animals; Cell Hypoxia; Cell Proliferation; Cell Survival; Cells, Cultured; Cobalt; Fingolimod Hydrochloride; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Myocytes, Cardiac; Pertussis Toxin; Protective Agents; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Tumor Suppressor Protein p53; Ursodeoxycholic Acid | 2017 |
Amygdaloid involvement in the defensive behavior of mice exposed to the open elevated plus-maze.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Behavior, Animal; Cobalt; Fear; Male; Mice; Proto-Oncogene Proteins c-fos | 2018 |
Comparison of allergen responses based on the TRUE Test and IQ Chamber system in Korean patients.
Topics: Adult; Aged; Allergens; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Nickel; Patch Tests; Phenylenediamines; Potassium Dichromate; Republic of Korea; Resins, Synthetic; Sensitivity and Specificity; Thimerosal | 2017 |
Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl
Topics: Animals; Apoptosis; Calcium Signaling; Caspase 3; Caspase 9; Cell Hypoxia; Cell Line; Cobalt; Connexin 43; Enzyme Inhibitors; Enzyme Precursors; Indicators and Reagents; Macrolides; Membrane Potential, Mitochondrial; Mitochondria, Heart; Mitochondrial Membranes; Myocytes, Cardiac; Protein Transport; Rats; Reactive Oxygen Species | 2018 |
Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population.
Topics: Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Papillary; Cell Hypoxia; Cell Line, Tumor; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplastic Stem Cells; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2018 |
Enamel matrix proteins regulate hypoxia-induced cellular biobehavior and osteogenic differentiation in human periodontal ligament cells.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Movement; Cell Proliferation; Cobalt; Core Binding Factor Alpha 1 Subunit; Dental Enamel Proteins; Down-Regulation; Endopeptidases; Humans; Hypoxia; Matrix Metalloproteinase 2; Osteogenesis; Peptide Fragments; Periodontal Ligament; Reference Standards; RNA, Messenger; Swine | 2017 |
Down-regulation of CASK in glucotoxicity-induced insulin dysfunction in pancreatic β cells.
Topics: Animals; Cell Line, Tumor; Cobalt; Disulfides; Down-Regulation; Glucose; Guanylate Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin Secretion; Insulin-Secreting Cells; Rats; Sulfonamides | 2018 |
Cobalt chloride compromises transepithelial barrier properties of CaCo-2 BBe human gastrointestinal epithelial cell layers.
Topics: Caco-2 Cells; Claudins; Cobalt; Gastrointestinal Tract; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Occludin; Permeability; Tight Junctions | 2018 |
Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Adhesion Molecules; Cell Line, Tumor; Cetuximab; Cobalt; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neuregulin-1; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; RNA Interference; RNA, Small Interfering; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Transplantation, Heterologous | 2018 |
The deep-subsurface sulfate reducer Desulfotomaculum kuznetsovii employs two methanol-degrading pathways.
Topics: Alcohol Dehydrogenase; Bacterial Proteins; Cobalt; Culture Media; Desulfotomaculum; Gene Expression; Gene Expression Profiling; Hydrolysis; Metabolic Networks and Pathways; Methanol; Methyltransferases; Oxidation-Reduction; Phylogeny; Proteomics; Vitamin B 12 | 2018 |
Translational control of human acetyl-CoA carboxylase 1 mRNA is mediated by an internal ribosome entry site in response to ER stress, serum deprivation or hypoxia mimetic CoCl
Topics: 5' Untranslated Regions; Acetyl-CoA Carboxylase; Cell Hypoxia; Cell Survival; Cobalt; Culture Media, Serum-Free; Endoplasmic Reticulum Stress; Hep G2 Cells; Humans; Internal Ribosome Entry Sites; Plasmids; Protein Biosynthesis; RNA Splicing; RNA, Messenger | 2018 |
Over-expression of DEC1 inhibits myogenic differentiation by modulating MyoG activity in bovine satellite cell.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cattle; Cell Differentiation; Cobalt; Down-Regulation; Muscle Development; Myogenin; Promoter Regions, Genetic; RNA, Messenger; Satellite Cells, Skeletal Muscle | 2018 |
Role of LncRNA MALAT-1 in hypoxia-induced PC12 cell injury via regulating p38MAPK signaling pathway.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Survival; Cobalt; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Rats; Reactive Oxygen Species; RNA, Long Noncoding; Signal Transduction | 2018 |
Measurement of In Vitro Single Cell Temperature by Novel Thermocouple Nanoprobe in Acute Lung Injury Models.
Topics: Acute Lung Injury; Adenosine Triphosphate; Animals; Cell Line; Cobalt; Disease Models, Animal; Energy Metabolism; Hydrochloric Acid; Hydrogen Peroxide; Lipopolysaccharides; Lung; Mice; Nanotechnology; Single-Cell Analysis; Temperature; Thermometry | 2017 |
Notch signaling molecule is involved in the invasion of MiaPaCa2 cells induced by CoCl2 via regulating epithelial‑mesenchymal transition.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cobalt; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Pancreatic Neoplasms; Receptor, Notch1; Receptors, Notch; Signal Transduction | 2018 |
FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Female; Fibronectins; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Tongue Neoplasms; Tumor Microenvironment | 2018 |
Neuroprotection by new ligustrazine-cinnamon acid derivatives on CoCl
Topics: Animals; Apoptosis; Cell Differentiation; Cell Survival; Cinnamates; Cobalt; Dose-Response Relationship, Drug; Molecular Structure; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Structure-Activity Relationship | 2018 |
Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia.
Topics: Animals; Apoptosis; Cell Death; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Imidazoles; Indoles; Mice; Muscle Fibers, Skeletal; Oxidative Stress; Protective Agents; Reactive Oxygen Species | 2018 |
ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia.
Topics: Animals; Cell Movement; Cell Shape; Cobalt; Female; Hypoxia; Insulin-Like Growth Factor I; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2018 |
Rig-I is involved in inflammation through the IPS-1/TRAF
Topics: Adaptor Proteins, Signal Transducing; Astrocytes; Cell Hypoxia; Cell Line, Tumor; Cobalt; DEAD Box Protein 58; Humans; Inflammation; Receptors, Immunologic; Signal Transduction; TNF Receptor-Associated Factor 6; Up-Regulation | 2018 |
Autophagy‑mediated adaptation of hepatocellular carcinoma cells to hypoxia‑mimicking conditions constitutes an attractive therapeutic target.
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Cobalt; Gene Knockdown Techniques; Humans; Liver Neoplasms; Macrolides; Morpholines; Oxygen; Signal Transduction | 2018 |
Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cerebrovascular Disorders; Cobalt; Drug Combinations; Drug Synergism; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Isoflavones; Middle Cerebral Artery; Myeloid Differentiation Factor 88; Neuroprotective Agents; NF-kappa B; PC12 Cells; Rats; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2018 |
Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cobalt; Oxidative Stress; Rats; Xanthones | 2018 |
Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Line; Cobalt; Enzyme Activation; Insulin-Secreting Cells; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Solute Carrier Proteins; Up-Regulation | 2018 |
The Methods and Mechanisms to Differentiate Endothelial-Like Cells and Smooth Muscle Cells from Mesenchymal Stem Cells for Vascularization in Vaginal Reconstruction.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Cells, Cultured; Cobalt; Endothelial Cells; Female; Fibroblast Growth Factor 2; Humans; Mesenchymal Stem Cells; Myocytes, Smooth Muscle; Neovascularization, Physiologic; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Tissue Engineering; Transforming Growth Factor beta1; Vagina; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; von Willebrand Factor; Wnt Signaling Pathway | 2018 |
Comparative study of the tissue distribution of equimolar repeated doses of hydroxocobalamin and cobalt chloride in the rats.
Topics: Animals; Cobalt; Dose-Response Relationship, Drug; Drug Administration Schedule; Hydroxocobalamin; Injections, Intraperitoneal; Rats; Rats, Wistar; Tissue Distribution; Toxicity Tests, Chronic | 2018 |
[Thrombopoietin Prevents CoCl
Topics: Apoptosis; Cells, Cultured; Cobalt; Human Umbilical Vein Endothelial Cells; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Thrombopoietin | 2018 |
Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors.
Topics: Amino Acids, Dicarboxylic; Bone Marrow Cells; Cell Differentiation; Cell Hypoxia; Child; Chondrogenesis; Cobalt; Deferoxamine; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Mesenchymal Stem Cells | 2018 |
CoCl
Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Child; Cobalt; Dynamins; Female; GTP Phosphohydrolases; Humans; Male; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Oxidative Stress; Periodontal Ligament; Reactive Oxygen Species; Signal Transduction; Stem Cells; Young Adult | 2018 |
Placental growth factor promotes epithelial-mesenchymal transition-like changes in ARPE-19 cells under hypoxia.
Topics: Actins; Antigens, CD; Cadherins; Cell Hypoxia; Cell Line; Cell Movement; Cell Proliferation; Cobalt; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Humans; NF-KappaB Inhibitor alpha; Nitriles; Placenta Growth Factor; Retinal Pigment Epithelium; Signal Transduction; Sulfones; Transcription Factor RelA; Zonula Occludens-1 Protein | 2018 |
Integrin β3 inhibits hypoxia-induced apoptosis in cardiomyocytes.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Hypoxia; Cell Line; Cell Proliferation; Cells, Cultured; Cobalt; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Integrin beta3; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; RNA Interference | 2018 |
Neuroprotective effects of isosteviol sodium through increasing CYLD by the downregulation of miRNA-181b.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Hypoxia; Cell Line, Tumor; Cobalt; Diterpenes, Kaurane; Down-Regulation; Male; Mice, Inbred C57BL; MicroRNAs; Mitochondria; Neuroprotective Agents; NF-kappa B; Tumor Suppressor Proteins | 2018 |
Determining the clinical relevance of positive patch testing to gold in evaluation of contact dermatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Child; Child, Preschool; Cobalt; Dermatitis, Allergic Contact; Female; Gold; Humans; Male; Middle Aged; Nickel; Patch Tests; Retrospective Studies; Young Adult | 2019 |
Cobalt treatment does not prevent glomerular morphological alterations in type 1 diabetic rats.
Topics: Animals; Cobalt; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Glomerulus; Male; Rats; Rats, Wistar | 2018 |
CoCl
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cobalt; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Hypoxia; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 7; Matrix Metalloproteinase 9; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Phosphorylation; Receptors, CXCR4; Signal Transduction; STAT3 Transcription Factor | 2018 |
Cysteine boosters the evolutionary adaptation to CoCl
Topics: Adaptation, Physiological; Biological Evolution; Carboplatin; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Cysteine; Drug Resistance, Neoplasm; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Ovarian Neoplasms | 2018 |
Potential role of HIF-1-responsive microRNA210/HIF3 axis on gemcitabine resistance in cholangiocarcinoma cells.
Topics: Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Bile Duct Neoplasms; Cell Line, Tumor; Cholangiocarcinoma; Cobalt; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; MicroRNAs; Neoplasm Proteins; Repressor Proteins; RNA, Neoplasm; Signal Transduction; Tumor Hypoxia | 2018 |
Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells.
Topics: Alveolar Epithelial Cells; Animals; Apoptosis; Autophagy; Caspase 9; Cell Line; Cobalt; Gene Expression Regulation, Enzymologic; Rats | 2018 |
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Topics: Antioxidant Response Elements; Antioxidants; Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Gene Knockdown Techniques; Humans; Hydroquinones; Keratinocytes; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2018 |
Ionic stress induces fusion of mitochondria to 3-D networks: An electron tomography study.
Topics: Cobalt; Electron Microscope Tomography; Microscopy, Electron, Transmission; Mitochondria; Osmolar Concentration; Potassium Chloride; Sodium Chloride | 2018 |
Apocynin Attenuates Cobalt Chloride-Induced Pheochromocytoma Cell Apoptosis by Inhibiting P38-MAPK/Caspase-3 Pathway.
Topics: Acetophenones; Adrenal Gland Neoplasms; Animals; Apoptosis; Caspase 3; Cell Survival; Cobalt; DNA Damage; Gene Expression; Imidazoles; Malondialdehyde; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pheochromocytoma; Pyridines; Rats; Signal Transduction; Superoxide Dismutase | 2018 |
The influence of 5-aminolevulinic photodynamic therapy on colon cancer cell interleukin secretion in hypoxia-like condition in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Survival; Cobalt; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Hypoxia; Interleukin-10; Interleukin-6; Interleukin-8; Interleukins; Photochemotherapy; Photosensitizing Agents | 2018 |
Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Celastrus; Cell Hypoxia; Cell Proliferation; Cell Shape; Cobalt; Down-Regulation; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Plant Extracts; Signal Transduction | 2019 |
Blockade of synaptic activity in the neostriatum and activation of striatal efferent pathways produce opposite effects on panic attack-like defensive behaviours evoked by GABAergic disinhibition in the deep layers of the superior colliculus.
Topics: Animals; Behavior, Animal; Cobalt; Corpus Striatum; Efferent Pathways; gamma-Aminobutyric Acid; Male; Motor Activity; N-Methylaspartate; Neural Inhibition; Neurotransmitter Agents; Panic Disorder; Rats, Wistar; Receptors, GABA-A; Superior Colliculi; Synaptic Transmission | 2018 |
Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and NLRP3 expression.
Topics: Cell Hypoxia; Cell Line; Cobalt; Complement C3; Complement C5; Complement C9; Complement Factor B; Complement Factor H; Epithelial Cells; Gene Expression Regulation; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; NLR Family, Pyrin Domain-Containing 3 Protein; Osmolar Concentration; Osmotic Pressure; Oxidative Stress; Protein Kinase Inhibitors; Retinal Pigment Epithelium; RNA, Small Interfering; Signal Transduction; Sodium Chloride; STAT Transcription Factors; Transcription Factors; Vascular Endothelial Growth Factor A | 2018 |
Contact allergy in Danish children: Current trends.
Topics: Adolescent; Allergens; Child; Child, Preschool; Cobalt; Denmark; Dermatitis, Allergic Contact; Dermatitis, Atopic; Female; Humans; Infant; Male; Nickel; Patch Tests; Perfume; Preservatives, Pharmaceutical; Prevalence; Retrospective Studies | 2018 |
Characterization of proliferative, glial and angiogenic responses after a CoCl
Topics: Age Factors; Animals; Antimutagenic Agents; Cell Proliferation; Cobalt; Neovascularization, Physiologic; Nerve Regeneration; Neuroglia; Photoreceptor Cells; Retina; Zebrafish | 2018 |
Dexmedetomidine Protects Against Chemical Hypoxia-Induced Neurotoxicity in Differentiated PC12 Cells Via Inhibition of NADPH Oxidase 2-Mediated Oxidative Stress.
Topics: Animals; Apoptosis; Calcium; Cell Hypoxia; Cobalt; Dexmedetomidine; Mitochondria; NADPH Oxidase 2; Neuroprotection; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats | 2019 |
Differentiated mitochondrial function in mouse 3T3 fibroblasts and human epithelial or endothelial cells in response to chemical exposure.
Topics: 3T3-L1 Cells; A549 Cells; Acetaminophen; Animals; Atropine; Caco-2 Cells; Cell Count; Cell Survival; Cobalt; Endothelial Cells; Ethanol; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Propranolol | 2019 |
AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia.
Topics: Adult; AMP-Activated Protein Kinases; Cell Movement; Cells, Cultured; Cobalt; Discriminant Analysis; Fatty Acids; Female; Humans; Least-Squares Analysis; Malondialdehyde; Matrix Metalloproteinase 2; Phosphorylation; Placenta; Pre-Eclampsia; Pregnancy; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Trophoblasts | 2018 |
Local Delivery of β-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Cells, Cultured; Cobalt; eIF-2 Kinase; Endoplasmic Reticulum Stress; Female; Heat-Shock Proteins; Neurons; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Recovery of Function; Sesquiterpenes; Signal Transduction; Spinal Cord Injuries; TOR Serine-Threonine Kinases; Transcription Factor CHOP | 2018 |
In Situ Imaging of Furin Activity with a Highly Stable Probe by Releasing of Precipitating Fluorochrome.
Topics: Cell Line, Tumor; Cobalt; Fluorescent Dyes; Furin; Golgi Apparatus; Humans; Hypoxia-Inducible Factor 1; Microscopy, Fluorescence; Peptides | 2018 |
Novel Polysaccharide H-1-2 from Pseudostellaria Heterophylla Alleviates Type 2 Diabetes Mellitus.
Topics: Animals; Blood Glucose; Caryophyllaceae; Cell Line; Cobalt; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin-Secreting Cells; Male; MicroRNAs; Polysaccharides; Promoter Regions, Genetic; Rats; Sirtuin 1; Up-Regulation | 2018 |
Regulation by Pink1 on the mitochondrial dysfunction in endothelial cells post the hypoxia mimetic agent CoCl2 treatment.
Topics: Apoptosis; Autophagy; Cell Hypoxia; Cell Line; Cobalt; Endothelial Cells; Gene Expression Regulation, Enzymologic; Humans; Mitochondria; Protein Kinases; Signal Transduction | 2018 |
Ionic cobalt but not metal particles induces ROS generation in immune cells in vitro.
Topics: Alloys; Arthroplasty, Replacement, Hip; Cobalt; Hip Prosthesis; Humans; Jurkat Cells; Leukocytes, Mononuclear; Superoxides | 2019 |
HIF-1
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Down-Regulation; Female; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Mesenchymal Stem Cells; Neurons; PTEN Phosphohydrolase; Rats, Sprague-Dawley; Up-Regulation | 2018 |
The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
Topics: Animals; Cell Line; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-6; Kidney; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Reperfusion Injury; RNA, Long Noncoding; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2018 |
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chromones; Cobalt; Disease Models, Animal; Erythropoietin; Humans; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Morpholines; Peptide Fragments; Proto-Oncogene Proteins c-akt; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway.
Topics: Animals; Apoptosis Regulatory Proteins; Biomarkers; Cells, Cultured; Chondrocytes; Chondrogenesis; Cobalt; Growth Plate; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Phenotype; Protein Serine-Threonine Kinases; Rats; Signal Transduction; YAP-Signaling Proteins | 2018 |
Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation.
Topics: Animals; Apoptosis; Asthma; Cell Line; Cobalt; Connexin 43; Disease Models, Animal; Epithelial Cells; Humans; Induced Pluripotent Stem Cells; Inflammation; Lung; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mitochondria; Nanotubes; Ovalbumin | 2018 |
Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction.
Topics: Adult; Calcium Channels; Calreticulin; Cell Line, Tumor; Cobalt; Female; Fetal Growth Retardation; Humans; Magnesium Sulfate; Placenta; Plasma Membrane Calcium-Transporting ATPases; Pre-Eclampsia; Pregnancy; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2019 |
Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Hypoxia; Cell Proliferation; Cell Survival; Cells, Cultured; Cobalt; Cyclin D1; Cyclin-Dependent Kinase 4; Drug Interactions; Human Umbilical Vein Endothelial Cells; Humans; L-Lactate Dehydrogenase; Propranolol; Proto-Oncogene Proteins c-bcl-2; Vascular Endothelial Growth Factor A | 2019 |
Protective effect of rutin isolated from Spermococe hispida against cobalt chloride-induced hypoxic injury in H9c2 cells by inhibiting oxidative stress and inducing apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Myocytes, Cardiac; Oxidative Stress; Plant Components, Aerial; Protective Agents; Rats; Rubiaceae; Rutin | 2018 |
Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways.
Topics: Adult; Apoptosis; Apoptosis Regulatory Proteins; Cell Hypoxia; Cell Survival; China; Cobalt; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Fibroblasts; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ligaments; Membrane Potential, Mitochondrial; Mitochondria; Pelvic Organ Prolapse; Primary Cell Culture; Receptors, Death Domain; Signal Transduction; Uterus | 2018 |
Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.
Topics: Animals; Apoptosis; Calcium; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Diterpenes, Kaurane; Extracellular Signal-Regulated MAP Kinases; Mice; Mitochondria; Neurons; Neuroprotective Agents; NF-kappa B; Reactive Oxygen Species; Signal Transduction | 2019 |
Evaluation of Angiogenesis Process after Metformin and LY294002 Treatment in Mammary Tumor.
Topics: Animals; Cell Line, Tumor; Chromones; Cobalt; Dog Diseases; Dogs; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Mammary Neoplasms, Animal; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Neovascularization, Pathologic; Oxygen; Vascular Endothelial Growth Factor A | 2019 |
A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride-induced acute hypoxic stress.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Blotting, Western; Cell Line; Cobalt; Cytoprotection; Humans; Hypoxia; Middle Aged; Oxidative Stress; Pentacyclic Triterpenes; Reactive Oxygen Species; Retinal Pigment Epithelium; Triterpenes | 2019 |
Deferoxamine but Not Dimethyloxalylglycine, L-Mimosine, or Cobalt Dichloride Can Interfere with the MTT Assay.
Topics: 3T3 Cells; Amino Acids, Dicarboxylic; Animals; Biocompatible Materials; Cell Line; Cell Survival; Cobalt; Deferoxamine; Dimethyl Sulfoxide; Mice; Mimosine; Tetrazolium Salts; Thiazoles | 2018 |
Cobalt chloride toxicity elicited hypertension and cardiac complication via induction of oxidative stress and upregulation of COX-2/Bax signaling pathway.
Topics: Animals; bcl-2-Associated X Protein; Cobalt; Cyclooxygenase 2; Heart; Hypertension; Kidney; Male; Myocardium; Oxidative Stress; Rats, Wistar; Up-Regulation | 2019 |
Exosomes derived miR-126 attenuates oxidative stress and apoptosis from ischemia and reperfusion injury by targeting ERRFI1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Cell Survival; Cobalt; Disease Models, Animal; Exosomes; HEK293 Cells; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Male; Membrane Potential, Mitochondrial; MicroRNAs; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Tumor Suppressor Proteins | 2019 |
Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Energy Metabolism; Flow Cytometry; Gene Expression Regulation; Humans; Mitochondria; Nuclear Respiratory Factor 1; Oxygen Consumption; Rats; Reactive Oxygen Species | 2019 |
Bioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations.
Topics: Animals; Biological Availability; Cobalt; Dust; Male; Metallurgy; Nickel; Soil Pollutants; Sus scrofa; Tissue Distribution | 2019 |
Allergic Contact Dermatitis to a Cell Phone.
Topics: Adult; Cell Phone; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Nickel; Patch Tests | 2018 |
Liver mitochondrial respiratory plasticity and oxygen uptake evoked by cobalt chloride in rats with low and high resistance to extreme hypobaric hypoxia.
Topics: Aerobiosis; Anaerobiosis; Animals; Cell Hypoxia; Cell Respiration; Cobalt; Liver; Male; Mitochondria; Oxygen Consumption; Rats | 2019 |
[G protein-coupled receptor 17 is involved in CoCl
Topics: Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Hypoxia; Receptors, G-Protein-Coupled; Retinal Ganglion Cells | 2018 |
The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue.
Topics: Amino Acids, Dicarboxylic; Biocompatible Materials; Cell Hypoxia; Cells, Cultured; Clay; Cobalt; Deferoxamine; Drug Delivery Systems; Fibroblasts; Humans; Hydrogels; Mimosine; Periodontium; Tissue Scaffolds | 2019 |
Differentially expressed coding and noncoding RNAs in CoCl
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Cobalt; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Gene Regulatory Networks; Mice; RNA, Messenger; RNA, Untranslated | 2019 |
Effects of cobalt chloride on the stem cell marker expression and osteogenic differentiation of stem cells from human exfoliated deciduous teeth.
Topics: Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Child; Cobalt; Healthy Volunteers; Humans; Mesenchymal Stem Cells; Osteogenesis; Tooth, Deciduous | 2019 |
Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Cardiotonic Agents; Cell Hypoxia; Cell Proliferation; Cell Survival; Cobalt; Genistein; Mitochondria; Myocytes, Cardiac; Rats; Up-Regulation | 2019 |
Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats.
Topics: Animals; Apoptosis; Biomarkers; Brain; Caspase 9; Cobalt; Heme Oxygenase (Decyclizing); Lipid Peroxidation; Male; Malondialdehyde; Metal Nanoparticles; Neurons; Neurotoxicity Syndromes; NF-E2 Transcription Factor, p45 Subunit; PC12 Cells; Rats; Rats, Wistar; Risk Assessment; Tissue Distribution | 2019 |
CoCl
Topics: Apoptosis; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Transfection | 2019 |
Ameliorative effects of melatonin against nano and ionic cobalt induced genotoxicity in two
Topics: Animals; Cobalt; Comet Assay; Dose-Response Relationship, Drug; Drosophila melanogaster; Hemocytes; Melatonin; Metal Nanoparticles; Mutagenicity Tests; Mutagens; Wings, Animal | 2020 |
Diminished apoptosis in hypoxic porcine retina explant cultures through hypothermia.
Topics: Amacrine Cells; Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Cell Hypoxia; Cobalt; Cold Temperature; In Vitro Techniques; Microglia; Neurodegenerative Diseases; Reactive Oxygen Species; Retinal Bipolar Cells; Retinal Diseases; Retinal Ganglion Cells; Swine | 2019 |
Neuroprotective Effects of Ginsenosides against Cerebral Ischemia.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cobalt; Ginsenosides; Male; Myeloid Differentiation Factor 88; Neuroprotective Agents; NF-kappa B; Panax; PC12 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Sirtuin 1; Toll-Like Receptor 4 | 2019 |
Intermedin protects HUVECs from ischemia reperfusion injury via Wnt/β-catenin signaling pathway.
Topics: beta Catenin; Cell Line; Cobalt; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imides; Neovascularization, Physiologic; Peptide Hormones; Quinolines; Receptor Activity-Modifying Protein 2; Reperfusion Injury; Up-Regulation; Vascular Endothelial Growth Factor A; Wnt Signaling Pathway | 2019 |
Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.
Topics: Cell Line; Cobalt; Deoxyribonuclease I; DNA, Viral; Gene Expression; Gene Expression Regulation, Enzymologic; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Liver Cirrhosis; Mutation; Virion; Virus Replication | 2019 |
Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.
Topics: Animals; Cobalt; Gene Expression Regulation; Glycine; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Knockout; Muscle, Skeletal; PAX7 Transcription Factor; Procollagen-Proline Dioxygenase; Regeneration; Stem Cells | 2019 |
[Propofol protects human cardiac AC16 cells from CoCl2-induced hypoxic injury].
Topics: Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Humans; Hypoxia; JNK Mitogen-Activated Protein Kinases; Propofol; Reactive Oxygen Species | 2019 |
Protein-Programmed Accumulation of Yeast Cytosine Deaminase in Cancer Cells in Response to Mock-Hypoxia.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Cytosine Deaminase; Fluorouracil; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Plasmids; Protein Domains; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2019 |
Syncytin 1, CD9, and CD47 regulating cell fusion to form PGCCs associated with cAMP/PKA and JNK signaling pathway.
Topics: CD47 Antigen; Cell Differentiation; Cell Fusion; Cell Line, Tumor; Cobalt; Colorectal Neoplasms; Cyclic AMP-Dependent Protein Kinases; Gene Products, env; Giant Cells; HCT116 Cells; Humans; MAP Kinase Signaling System; Polyploidy; Pregnancy Proteins; Tetraspanin 29 | 2019 |
A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain.
Topics: Animals; Biosensing Techniques; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cobalt; Female; Fluorescent Dyes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Mice; Mice, Inbred BALB C; Mice, Nude; Mimosine; Oxygen; Peptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Domains; Proteolysis; Spectrometry, Fluorescence | 2019 |
BNIP3-mediated Autophagy Induced Inflammatory Response and Inhibited VEGF Expression in Cultured Retinal Pigment Epithelium Cells Under Hypoxia.
Topics: Autophagy; Biomarkers; Cell Hypoxia; Cell Line; Cell Survival; Cells, Cultured; Cobalt; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Proto-Oncogene Proteins; Retinal Pigment Epithelium; RNA Interference; Signal Transduction; Vascular Endothelial Growth Factor A | 2019 |
LncRNA NEAT1 promotes hypoxia-induced renal tubular epithelial apoptosis through downregulating miR-27a-3p.
Topics: Acute Kidney Injury; Apoptosis; Case-Control Studies; Cell Hypoxia; Cell Line; Cobalt; Down-Regulation; Epithelial Cells; Humans; Kidney Tubules; MicroRNAs; RNA, Long Noncoding; Signal Transduction | 2019 |
Effect of Cobalt Chloride on Fermentation of Alfalfa and Smooth Bromegrass Hays by Horse Cecal Microorganisms.
Topics: Animals; Bromus; Cobalt; Digestion; Fermentation; Horses; Medicago sativa | 2019 |
Long non-coding RNA ROR mitigates cobalt chloride-induced hypoxia injury through regulation of miR-145.
Topics: Cell Hypoxia; Cell Line; Cobalt; Down-Regulation; Gene Silencing; Humans; MAP Kinase Signaling System; MicroRNAs; RNA, Long Noncoding; Up-Regulation | 2019 |
Delayed hypersensitivity to palladium dichloride: 15-year retrospective study in a skin allergy unit.
Topics: Adult; Age Factors; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Male; Nickel; Palladium; Patch Tests; Potassium Dichromate; Prevalence; Retrospective Studies; Sex Factors; Spain | 2019 |
Novel Cobalt Dichloride Complexes with Hindered Diphenylphosphine Ligands: Synthesis, Characterization, and Behavior in the Polymerization of Butadiene.
Topics: Butadienes; Catalysis; Cobalt; Coordination Complexes; Ligands; Models, Molecular; Molecular Structure; Phosphines; Polymerization | 2019 |
Hypoxia as a Factor Involved in the Regulation of the apoA-1, ABCA1, and Complement C3 Gene Expression in Human Macrophages.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; Cell Hypoxia; Cell Line, Tumor; Cobalt; Complement C3; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Up-Regulation | 2019 |
Role of integrin-linked kinase in the hypoxia-induced phenotypic transition of pulmonary artery smooth muscle cells: Implications for hypoxic pulmonary hypertension.
Topics: Actins; Animals; Biomarkers; Calcium-Binding Proteins; Calponins; Cell Hypoxia; Cobalt; Down-Regulation; ets-Domain Protein Elk-1; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Microfilament Proteins; Models, Biological; Myocytes, Smooth Muscle; Nuclear Proteins; Osteopontin; Phenotype; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Pulmonary Artery; Rats, Sprague-Dawley; RNA, Messenger; Serum Response Factor; Trans-Activators; Vascular Remodeling | 2019 |
Inhibition of miR-337-3p involved in the protection of CoCl
Topics: Animals; Apoptosis; Cobalt; Janus Kinase 2; Membrane Potentials; MicroRNAs; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; STAT3 Transcription Factor | 2019 |
Hypoxia-induced epithelial-mesenchymal transition and fibrosis for the development of breast capsular contracture.
Topics: Animals; Breast Implants; Cell Hypoxia; Cobalt; Contracture; Epithelial-Mesenchymal Transition; Extracellular Matrix; Female; Fibronectins; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Implant Capsular Contracture; Matrix Metalloproteinase 9; Mice; NIH 3T3 Cells; Vimentin | 2019 |
Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Neovascularization, Pathologic; Prognosis; Vimentin | 2019 |
Insulin-like growth factor-I prevents hypoxia-inducible factor-1 alpha-dependent G1/S arrest by activating cyclin E/cyclin-dependent kinase2 via the phoshatidylinositol-3 kinase/AKT/forkhead box O1/Cdkn1b pathway in porcine granulosa cells†.
Topics: Animals; Cell Cycle; Cell Cycle Checkpoints; Cell Hypoxia; Cobalt; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Estradiol; Female; Follicle Stimulating Hormone; Forkhead Box Protein O1; Granulosa Cells; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Swine | 2020 |
CoCl
Topics: Animals; Bone Marrow Cells; Cannabinoids; Cell Differentiation; Cells, Cultured; Cobalt; Hypoxia; Mesenchymal Stem Cells; Osteogenesis; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2 | 2019 |
Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta.
Topics: Animals; Becaplermin; Cell Line; Cell Movement; Cellular Senescence; Cobalt; Computational Biology; Down-Regulation; Gene Expression Regulation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Protein Binding; Rats | 2019 |
Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function.
Topics: Animals; Cell Communication; Cell Hypoxia; Cobalt; Electron Transport Complex IV; Endothelial Cells; Gene Expression Regulation; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Vascular Endothelial Growth Factor A | 2019 |
Trend of relevant contact allergens of the feet in Spain over a period of 10 years.
Topics: Adult; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dermatitis, Irritant; Dermatitis, Occupational; Eczema, Dyshidrotic; Female; Foot Dermatoses; Humans; Male; Potassium Dichromate; Psoriasis; Resins, Synthetic; Retrospective Studies; Spain; Sulfhydryl Compounds | 2020 |
A role of AMPK and connexin 43 in the suppression of CoCl
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Antimutagenic Agents; Apoptosis; Arteries; Cobalt; Cochlea; Connexin 43; Gene Expression Regulation; Guinea Pigs; Hypoxia; Muscle, Smooth, Vascular; Reactive Oxygen Species | 2019 |
Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling.
Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Bone Regeneration; Cell Differentiation; Cell Hypoxia; Cobalt; Femur; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteoblasts; Osteogenesis; Phosphorylation; Primary Cell Culture; Signal Transduction; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A; Wound Healing | 2019 |
Soluble electron acceptors affect bioluminescence from Shewanella woodyi.
Topics: Cobalt; Electrochemical Techniques; Electrodes; Electrons; Luminescence; Luminescent Measurements; Nitrates; Shewanella; Solubility | 2020 |
Hypoxia-inducible factor-1α mediates the expression of mature β cell-disallowed genes in hypoxia-induced β cell dedifferentiation.
Topics: Animals; Cell Dedifferentiation; Cell Hypoxia; Cell Line; Cobalt; Diabetes Mellitus, Type 2; Gene Expression; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Secreting Cells; Islets of Langerhans; Mice; Signal Transduction | 2020 |
Application of tandem biotransformation for biosynthesis of new pentacyclic triterpenoid derivatives with neuroprotective effect.
Topics: Animals; Bacillus subtilis; Cobalt; Glycosylation; Glycyrrhetinic Acid; Molecular Conformation; Neurons; Neuroprotective Agents; Oleanolic Acid; PC12 Cells; Rats; Rhizopus; Streptomyces; Triterpenes | 2020 |
Patch testing in Lao medical students.
Topics: 2-Naphthylamine; Adolescent; Adult; Allergens; Balsams; Cobalt; Dermatitis, Allergic Contact; Epoxy Resins; Female; Gold; Humans; Laos; Male; Middle Aged; Nickel; Patch Tests; Phenylenediamines; Resins, Synthetic; Students, Medical; Thimerosal | 2020 |
Metabolic disparities of different oxidative stress‑inducing conditions in HTR8/SVneo cells.
Topics: Adult; Cell Line; Cell Survival; Cells, Cultured; Cobalt; Humans; Metabolism; Metabolome; Metabolomics; Models, Biological; Nitroprusside; Oxidative Stress; Principal Component Analysis | 2020 |
Hypoxic environment may enhance migration/penetration of endocrine resistant MCF7- derived breast cancer cells through monolayers of other non-invasive cancer cells in vitro.
Topics: Basement Membrane; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Coculture Techniques; Deferoxamine; Epithelial-Mesenchymal Transition; Estrogens; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Receptors, Estrogen; RNA, Small Interfering; Sepharose | 2020 |
P2X7 and A
Topics: Animals; Cell Death; Cobalt; Nerve Degeneration; Nerve Regeneration; Neurons; Photoreceptor Cells, Vertebrate; Receptor, Adenosine A2A; Receptors, Purinergic P2X7; Zebrafish | 2020 |
Cardioprotective effects of genetically engineered cardiac stem cells by spheroid formation on ischemic cardiomyocytes.
Topics: Animals; Ataxin-1; Cell Adhesion; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Proliferation; Cell Survival; Chemokine CXCL12; Cobalt; Gene Expression Regulation; Genetic Engineering; Myocytes, Cardiac; Paracrine Communication; Promoter Regions, Genetic; Rats; Receptors, CXCR4; Spheroids, Cellular; Stem Cells; Telomerase | 2020 |
Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate.
Topics: Administration, Oral; Animals; Biological Availability; Cobalt; Female; Gastric Juice; Injections, Intravenous; Intestinal Secretions; Male; Oxides; Rats, Sprague-Dawley; Risk Assessment; Solubility; Toxicokinetics | 2020 |
Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia.
Topics: Animals; Aorta, Abdominal; Cell Hypoxia; Cell Line; Cell Movement; Cell Proliferation; Circadian Clocks; Cobalt; Disease Models, Animal; Female; Gene Expression Regulation; Gene Silencing; Humans; Hypoxia; Placenta; Pre-Eclampsia; Pregnancy; Rats; RNA, Messenger; Signal Transduction; Transfection; Trophoblasts; Uterine Artery | 2020 |
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Topics: Animals; Butadienes; Cell Hypoxia; Cell Survival; Cobalt; Culture Media, Serum-Free; Cyclin A; Ferroptosis; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Nitriles; Nitroprusside; Poly(ADP-ribose) Polymerases; Serum; Transferrin | 2020 |
Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles.
Topics: Animals; Caspase 1; Choline Deficiency; Cobalt; Disease Models, Animal; Extracellular Vesicles; Fatty Acids, Nonesterified; Gene Expression Regulation; Hepatocytes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammasomes; Inflammation; Interleukin-1beta; Kupffer Cells; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Rats; Sleep Apnea, Obstructive; Triglycerides | 2020 |
A circRNA derived from linear HIPK3 relieves the neuronal cell apoptosis in spinal cord injury via ceRNA pattern.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Base Sequence; Blood-Brain Barrier; Cell Line; Cobalt; Disease Models, Animal; Down-Regulation; Humans; Hydrolases; MicroRNAs; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; RNA, Circular; Spinal Cord Injuries | 2020 |
Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase.
Topics: Alcohol Dehydrogenase; Cobalt; Coordination Complexes; Crystallography, X-Ray; Imidazoles; Ligands; Liver; Models, Chemical; Nitrogen; Spectrometry, Mass, Electrospray Ionization; Sulfur; Zinc | 2020 |
miR-150-5p mediates extravillous trophoblast cell migration and angiogenesis functions by regulating VEGF and MMP9.
Topics: Adult; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Female; Gene Expression Regulation; Humans; Infant, Newborn; Matrix Metalloproteinase 9; MicroRNAs; Neovascularization, Physiologic; Pregnancy; Trophoblasts; Vascular Endothelial Growth Factor A | 2020 |
Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel.
Topics: Adenosine Diphosphate Ribose; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cobalt; HEK293 Cells; Humans; Hydrogen Peroxide; Hypoxia, Brain; Mitochondria; Neurons; Oxidative Stress; Resveratrol; TRPM Cation Channels | 2020 |
The role of miR-711 in cardiac cells in response to oxidative stress and its biogenesis: a study on H9C2 cells.
Topics: Angiopoietin-1; Animals; Antimycin A; Apoptosis; Calcium Channels, L-Type; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Fibroblast Growth Factors; Gene Knockdown Techniques; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; MicroRNAs; Mitochondria; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; Rats; RNA, Small Interfering; Signal Transduction; Up-Regulation | 2020 |
HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions.
Topics: Adult; Apoptosis; Case-Control Studies; Cell Hypoxia; Cell Line; Cobalt; Female; Forkhead Box Protein O3; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Placenta; Pre-Eclampsia; Pregnancy; RNA Interference; RNA, Small Interfering; Trophoblasts; Up-Regulation | 2020 |
Moringa oleifera leaves ethanolic extract influences DNA damage signaling pathways to protect liver tissue from cobalt -triggered apoptosis in rats.
Topics: Animals; Antioxidants; Apoptosis; Cobalt; DNA Damage; Ethanol; HSP70 Heat-Shock Proteins; Liver; Male; Moringa oleifera; Oxidative Stress; Plant Extracts; Plant Leaves; Rats; Reactive Oxygen Species; Signal Transduction | 2020 |
Cobalt chloride, a chemical hypoxia-mimicking agent, suppresses myoblast differentiation by downregulating myogenin expression.
Topics: Animals; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cell Survival; Cells, Cultured; Cobalt; Down-Regulation; Mice; Muscle Development; Myoblasts; Myogenin; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; RNA, Messenger; Signal Transduction | 2020 |
Comparative Analysis of the Paracrine Action of Neuronal and Glial Progenitor Cells Derived from Induced Human Pluripotent Stem Cells.
Topics: Cell Differentiation; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Coculture Techniques; Humans; Induced Pluripotent Stem Cells; Nerve Growth Factors; Neural Stem Cells; Neuroglia; Neurons; Paracrine Communication | 2020 |
Extracellular vesicles derived from fat-laden hepatocytes undergoing chemical hypoxia promote a pro-fibrotic phenotype in hepatic stellate cells.
Topics: Animals; Cell Communication; Cell Hypoxia; Cobalt; Culture Media; Disease Models, Animal; Disease Progression; Extracellular Vesicles; Fatty Acids, Nonesterified; Hep G2 Cells; Hepatic Stellate Cells; Hepatocytes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Cirrhosis; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Sleep Apnea, Obstructive | 2020 |
Co-Culturing of Endothelial and Cancer Cells in a Nanofibrous Scaffold-Based Two-Layer System.
Topics: Animals; Cell Hypoxia; Cell Proliferation; Chloroform; Cobalt; Coculture Techniques; Colonic Neoplasms; Dimethylformamide; Endothelial Cells; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Membranes, Artificial; Mice; Nanofibers; Neovascularization, Pathologic; Polyesters; Vascular Endothelial Growth Factor A | 2020 |
Adenosine kinase inhibition attenuates ischemia reperfusion-induced acute kidney injury.
Topics: Acute Kidney Injury; Adenosine Kinase; Adult; Animals; Apoptosis; Cell Line; Cobalt; Enzyme Inhibitors; Female; Humans; Inflammation; Inosine; Kidney Tubules; Male; Mice, Inbred C57BL; Morpholines; Necrosis; Oxidative Stress; Pyrimidines; Reperfusion Injury | 2020 |
Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway.
Topics: Animals; Apoptosis; Cell Line; Cobalt; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Humans; Male; Myocardial Ischemia; Rats; Reactive Oxygen Species; Rosuvastatin Calcium; Signal Transduction | 2020 |
Increased expression and retention of the secretory chaperone proSAAS following cell stress.
Topics: Animals; Arsenites; Cell Hypoxia; Cell Line; Cobalt; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Mice; Molecular Chaperones; Neuropeptides; Oxidative Stress; Protective Agents; Rats; RNA, Messenger; Sodium Compounds; Stress, Physiological; Thapsigargin; Tunicamycin; Up-Regulation | 2020 |
Drp-1-Dependent Mitochondrial Fragmentation Contributes to Cobalt Chloride-Induced Toxicity in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chlorides; Cobalt; Dynamins; Mitochondria; Oxidative Stress | 2020 |
Transcriptomic analysis reveals the role of a peptide derived from CRYAB on the CoCl
Topics: alpha-Crystallin B Chain; Animals; Apoptosis; Cell Hypoxia; Cell Line; Cobalt; Gene Expression Regulation; Mice; Myocytes, Cardiac; Peptides; Transcriptome | 2021 |
Ameliorative Effect of Ananas comosus on Cobalt Chloride-Induced Hypoxia in Caco2 cells via HIF-1α, GLUT 1, VEGF, ANG and FGF.
Topics: Ananas; Caco-2 Cells; Cell Hypoxia; Cobalt; Fibroblast Growth Factors; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Vascular Endothelial Growth Factor A | 2021 |
MicroRNA-203a-3p regulates CoCl
Topics: Animals; Antimutagenic Agents; Apoptosis; Cell Culture Techniques; Cobalt; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Epithelial Cells; Humans; MicroRNAs; Rats; Retinal Pigment Epithelium; Suppressor of Cytokine Signaling 3 Protein | 2020 |
Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib.
Topics: Actins; AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Autophagy; Cell Survival; Cobalt; Dinoprost; Drug Therapy, Combination; Endoplasmic Reticulum; Glucose; Glycolysis; Humans; Male; Metformin; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Nitric Oxide; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2020 |
Cytotoxicity of cobalt chloride in brain cell lines - a comparison between astrocytoma and neuroblastoma cells.
Topics: Astrocytes; Astrocytoma; Biological Transport; Brain; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cobalt; Humans; Neuroblastoma; Neurons | 2020 |
New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect.
Topics: Animals; Bacillus megaterium; Betulinic Acid; Biotransformation; Cell Survival; Cobalt; Hydroxylation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Neurons; Neuroprotective Agents; Oxidation-Reduction; PC12 Cells; Pentacyclic Triterpenes; Rats | 2020 |
Cobalt accumulation and iron-regulatory protein profile expression in immature mouse brain after perinatal exposure to cobalt chloride.
Topics: Animals; Body Weight; Brain; Cation Transport Proteins; Cobalt; Female; Gene Expression Regulation, Developmental; Hepcidins; Iron; Iron-Regulatory Proteins; Mice; Mice, Inbred ICR; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Transferrin | 2020 |
Hypoxia Protects Rat Bone Marrow Mesenchymal Stem Cells Against Compression-Induced Apoptosis in the Degenerative Disc Microenvironment Through Activation of the HIF-1α/YAP Signaling Pathway.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Survival; Cellular Microenvironment; Cobalt; Cytoprotection; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Intervertebral Disc Degeneration; Intracellular Signaling Peptides and Proteins; Mesenchymal Stem Cells; Models, Biological; Rats, Sprague-Dawley; Signal Transduction; Stress, Mechanical; YAP-Signaling Proteins | 2020 |
Human L-Dopa decarboxylase interaction with annexin V and expression during apoptosis.
Topics: Animals; Annexin A5; Apoptosis; Aromatic-L-Amino-Acid Decarboxylases; Cell Death; Cell Line; Cell Line, Tumor; Cobalt; Cricetinae; Enzyme Inhibitors; Female; Humans; Placenta; Pregnancy; Protein Isoforms; Staurosporine | 2020 |
HIF-1α induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro.
Topics: Animals; Apoptosis; Caspase 3; Cell Differentiation; Cell Hypoxia; Cell Line; Cobalt; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Mice; Osteocytes; Osteogenesis; RNA, Messenger; RNA, Small Interfering; Up-Regulation | 2020 |
Composition, antioxidant activity, and neuroprotective effects of anthocyanin-rich extract from purple highland barley bran and its promotion on autophagy.
Topics: Animals; Anthocyanins; Antioxidants; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cobalt; Hordeum; Humans; Mass Spectrometry; Neuroprotective Agents; PC12 Cells; Plant Extracts; Rats; Reactive Oxygen Species | 2021 |
Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Cell Adhesion Molecules; Cobalt; Dietary Supplements; Gallic Acid; Kidney; Luteolin; Male; Myocardium; NF-kappa B; Oxidative Stress; Rats, Wistar; Signal Transduction | 2020 |
Moderate hypothermia induces protection against hypoxia/reoxygenation injury by enhancing SUMOylation in cardiomyocytes.
Topics: Animals; Caspase 3; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Gene Expression Regulation; Hypothermia, Induced; Membrane Potential, Mitochondrial; Mitochondria; Models, Biological; Myocytes, Cardiac; Oxygen; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; SUMO-1 Protein; Sumoylation | 2020 |
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Topics: Alkaline Phosphatase; Apoptosis; Autophagy; Cell Proliferation; Cobalt; Collagen Type I; Collagen Type I, alpha 1 Chain; Core Binding Factor Alpha 1 Subunit; Cyclin-Dependent Kinase 8; Endoplasmic Reticulum Stress; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mesenchymal Stem Cells; Osteocalcin; Osteogenesis; Periodontal Ligament; Periodontitis; RNA, Circular; Signal Transduction | 2021 |
Suitable test concentration of cobalt and concomitant reactivity to nickel and chromium: A multicentre study from the Swedish Contact Dermatitis Research Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; Child; Cobalt; Dermatitis, Allergic Contact; Female; Humans; Male; Middle Aged; Nickel; Patch Tests; Potassium Dichromate; Sweden; Young Adult | 2021 |
Mesenchymal stem cell‑derived extracellular vesicles prevent neural stem cell hypoxia injury via promoting miR‑210‑3p expression.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Cell Hypoxia; Cells, Cultured; Cobalt; Extracellular Vesicles; Female; Hippocampus; Membrane Proteins; Mesenchymal Stem Cells; MicroRNAs; Mitochondrial Proteins; Neural Stem Cells; Pregnancy; Rats; Signal Transduction; Transfection | 2020 |
A Fairy Chemical Suppresses Retinal Angiogenesis as a HIF Inhibitor.
Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cobalt; Corneal Dystrophies, Hereditary; Disease Models, Animal; Gene Expression Regulation; Hypoxia-Inducible Factor 1; Mice; Retinal Neovascularization; Vascular Endothelial Growth Factor A | 2020 |
Protective Effects of Adiponectin against Cobalt Chloride-Induced Apoptosis of Smooth Muscle Cells via cAMP/PKA Pathway.
Topics: Adiponectin; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cobalt; Cochlea; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guinea Pigs; Myocytes, Smooth Muscle; Protective Agents; Signal Transduction | 2020 |
HIFα independent mechanisms in renal carcinoma cells modulate divergent outcomes in fibronectin assembly mediated by hypoxia and CoCl
Topics: Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cobalt; Extracellular Matrix; Fibronectins; Humans; Hypoxia; Kidney Neoplasms; Tumor Microenvironment | 2020 |
Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats.
Topics: Alcoholism; Animals; Behavior, Animal; Cobalt; Disease Models, Animal; Extinction, Psychological; Hippocampus; Male; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2021 |
Involvement of the ventral, but not dorsal, hippocampus in anxiety-like behaviors in mice exposed to the elevated plus maze: participation of CRF1 receptor and PKA pathway.
Topics: Aminopyridines; Animals; Anxiety; Behavior, Animal; Cobalt; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Isoquinolines; Male; Maze Learning; Mice; Microinjections; Motor Activity; Protein Kinase Inhibitors; Receptors, Corticotropin-Releasing Hormone; Signal Transduction; Sulfonamides | 2021 |
Neuregulin-1 inhibits CoCl
Topics: Animals; Antioxidants; Apoptosis; bcl-X Protein; Caspase 3; Cell Line, Tumor; Cobalt; Excitatory Amino Acid Transporter 3; Hippocampus; Humans; Male; Mice, Inbred C57BL; Microinjections; Neuregulin-1; Oxidative Stress; Phosphorylation; Superoxides; tau Proteins; Up-Regulation | 2020 |
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Topics: Cell Hypoxia; Cell Line; Cell Movement; Cell Nucleus; Cobalt; Female; Glycogen Synthase Kinase 3 beta; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Placenta; Pregnancy; Protein Stability; Proto-Oncogene Proteins c-akt; Repressor Proteins; Signal Transduction; Transcription, Genetic; Trophoblasts | 2021 |
Cobalt Chloride Induces Macrophage Foam Cell Formation: A Chemical Hypoxia Model for Anti-Atherosclerotic Drug Screening.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Cell Hypoxia; Cells, Cultured; Cobalt; Drug Evaluation, Preclinical; Macrophages; Mice; Models, Biological; RAW 264.7 Cells | 2021 |
Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors.
Topics: Aged; Animals; Cobalt; Disease Models, Animal; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Infant, Newborn; Macular Degeneration; Mice; Neovascularization, Pathologic; Oryza; Retina; Retinal Pigment Epithelium; Rice Bran Oil; Vascular Endothelial Growth Factor A; Vitamin B 6 | 2020 |
Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.
Topics: Cell Hypoxia; Cell Line; Cobalt; Endoplasmic Reticulum; Epithelial Cells; Epithelium, Corneal; Exosomes; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Thrombospondin 1; Wound Healing | 2021 |
Propofol protects PC12 cells from cobalt chloride-induced injury by mediating miR-134.
Topics: Animals; Apoptosis; Autophagy; Cell Survival; Cobalt; Membrane Potential, Mitochondrial; MicroRNAs; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Propofol; Rats; Reactive Oxygen Species | 2021 |
Chemical genetics of regeneration: Contrasting temporal effects of CoCl
Topics: Ambystoma mexicanum; Amputation, Surgical; Animals; Cell Death; Cobalt; Depsipeptides; Histone Deacetylase Inhibitors; Regeneration; Tail; Time Factors | 2021 |
Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.
Topics: Animals; Cell Hypoxia; Cell Line; Cobalt; Glioblastoma; Glyceraldehyde-3-Phosphate Dehydrogenases; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Oxidation-Reduction; Protein Aggregates; Protein Binding; Rats | 2021 |
Differentiation of Hodgkin lymphoma cells by reactive oxygen species and regulation by heme oxygenase-1 through HIF-1α.
Topics: Cell Differentiation; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Hodgkin Disease; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Protoporphyrins; Reactive Oxygen Species | 2021 |
Circ_HIPK3 alleviates CoCl
Topics: Apoptosis; Base Sequence; Cell Line; Cobalt; Dual-Specificity Phosphatases; Humans; MicroRNAs; Neurons; RNA, Circular | 2021 |
[Human dental pulp stem cells conditioned medium protects genioglossus myoblast from cobalt chloride-induced hypoxia injury through AMPK/PGC-1α pathway].
Topics: AMP-Activated Protein Kinases; Animals; Cobalt; Culture Media, Conditioned; Dental Pulp; Humans; Hypoxia; Mice; Myoblasts | 2020 |
Cobalt chloride-simulated hypoxia elongates primary cilia in immortalized human retina pigment epithelial-1 cells.
Topics: Cell Hypoxia; Cell Line, Transformed; Cilia; Cobalt; Dose-Response Relationship, Drug; Down-Regulation; Humans; Prolyl Hydroxylases; Retinal Pigment Epithelium; Telomerase; Vesicular Transport Proteins | 2021 |
Real-Time Monitoring the Effect of Cytopathic Hypoxia on Retinal Pigment Epithelial Barrier Functionality Using Electric Cell-Substrate Impedance Sensing (ECIS) Biosensor Technology.
Topics: Biosensing Techniques; Cell Adhesion; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Dose-Response Relationship, Drug; Electric Impedance; Electrodes; Humans; Mitochondria; Retinal Pigment Epithelium; Zonula Occludens-1 Protein | 2021 |
Concomitant allergic contact dermatitis and aquagenic urticaria caused by personal protective equipment in a healthcare worker during the COVID-19 pandemic.
Topics: Chronic Inducible Urticaria; Cobalt; COVID-19; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Humans; Nursing Staff, Hospital; Patch Tests; Personal Protective Equipment; Urticaria; Young Adult | 2021 |
Neuroprotective Potency of Tofu Bio-Processed Using
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Hypoxia; Chromatography, High Pressure Liquid; Cobalt; Fermentation; Mucorales; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Phenols; Rats; Soy Foods | 2021 |
Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt. Effects of high and low calcium growth conditions.
Topics: Calcium; Cell Differentiation; Cell Line; Cell Survival; Chemokine CCL2; Chemokines; Cobalt; Cytokines; Gene Expression; Humans; Interleukin-6; Interleukin-8; Keratinocytes; Signal Transduction; Skin | 2021 |
Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Glioblastoma; Humans; Mice; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Signal Transduction | 2021 |
Effect of Mimic Hypoxia on the Proliferation and Expression of miR-27a, miR-9, miR-370 and their Target Genes in MOLT-4 and KG1a Cell Lines.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Drug Resistance; Humans; MicroRNAs; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT
Topics: Animals; Cannabidiol; Chronic Disease; Cobalt; Depression; Limbic System; Microinjections; Neuralgia; Piperazines; Piperidines; Prefrontal Cortex; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Sciatica; Serotonin 5-HT1 Receptor Antagonists; Swimming; Synapses | 2021 |
Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway.
Topics: Acetylcholine; Adult; Apoptosis; Atropine; Cell Hypoxia; Cell Movement; Cobalt; Female; Humans; MAP Kinase Signaling System; Muscarinic Antagonists; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pre-Eclampsia; Pregnancy; Reactive Oxygen Species; Trophoblasts; Vagus Nerve | 2021 |
Signal transducer and activator of transcription-3 mediated neuroprotective effect of interleukin-6 on cobalt chloride mimetic hypoxic cell death in R28 cells.
Topics: Animals; Apoptosis; Cell Death; Cell Hypoxia; Cell Line; Cell Survival; Cobalt; Hypoxia; Interleukin-6; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidative Stress; Rats; Retina; Signal Transduction; STAT3 Transcription Factor | 2021 |
Skin permeation of nickel, cobalt and chromium salts in ex vivo human skin, visualized using mass spectrometry imaging.
Topics: Chlorides; Chromium Compounds; Cobalt; Female; Haptens; Humans; In Vitro Techniques; Mass Spectrometry; Nickel; Skin; Skin Absorption | 2021 |
Chemical Induction of Trophoblast Hypoxia by Cobalt Chloride Leads to Increased Expression of DDIT3.
Topics: Caspase 3; Caspase 7; Cell Hypoxia; Cell Line, Tumor; Cobalt; Female; Gene Expression Regulation; Humans; Pregnancy; Transcription Factor CHOP; Trophoblasts | 2021 |
Genomic organization and hypoxia inducible factor responsive regulation of teleost hsp90β gene during hypoxia stress.
Topics: Animals; Animals, Genetically Modified; Cell Hypoxia; Cobalt; Exons; Gene Deletion; Gene Expression; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; HEK293 Cells; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1; Introns; Luciferases; Promoter Regions, Genetic; TATA-Box Binding Protein; Transfection; Zebrafish; Zebrafish Proteins | 2021 |
Cobalt chloride-stimulated hypoxia promotes the proliferation of cholesteatoma keratinocytes via the PI3K/Akt signaling pathway.
Topics: Cell Hypoxia; Cell Proliferation; Cholesteatoma; Cobalt; Humans; Keratinocytes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2021 |
Transcriptome sequencing reveals Gastrodia elata Blume could increase the cell viability of eNPCs under hypoxic condition by improving DNA damage repair ability.
Topics: Animals; Cell Survival; Cobalt; DNA Damage; DNA Repair; Embryo, Mammalian; Gastrodia; Gene Expression Regulation; Gene Regulatory Networks; Mice; Neural Stem Cells; Oxygen; Plant Extracts; RNA-Seq | 2022 |
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia
Topics: Animals; Apoptosis; Cells, Cultured; Cobalt; Hypoxia; Intervertebral Disc Degeneration; Nucleus Pulposus; Rats | 2021 |
Diazoxide Needs Mitochondrial Connexin43 to Exert Its Cytoprotective Effect in a Cellular Model of CoCl
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cobalt; Connexin 43; Cytoprotection; Diazoxide; Hypoxia; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Potassium Channels; Rats; Reactive Oxygen Species | 2021 |
Tongxin formula protects H9c2 cardiomyocytes from cobalt chloride-induced hypoxic injury via inhibition of apoptosis.
Topics: Apoptosis; Cell Survival; Cobalt; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt | 2021 |
Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas.
Topics: Animals; Apoptosis; Cobalt; Complement Activation; Complement Pathway, Alternative; Complement Pathway, Classical; Complement System Proteins; Hydrogen Peroxide; Hypoxia; Lectins; Microglia; Oxidative Stress; Retina; Retinal Ganglion Cells; Retinal Neurons; Stress, Physiological; Swine | 2021 |
Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cobalt; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mitophagy; Rats; Reactive Oxygen Species | 2022 |
Hypoxia-Mimetic CoCl
Topics: Animals; Cobalt; Culture Media, Conditioned; Epithelial Cells; Hypoxia; Oxygen; Sheep; Vascular Endothelial Growth Factor A | 2022 |
Effect of fluorescence quenching model on quinoline derivative with cobalt chloride metal ion using steady state and time resolved spectroscopic methods.
Topics: Cobalt; Fluorescence; Fluorescence Resonance Energy Transfer; Ions; Metals; Quinolines; Spectrometry, Fluorescence | 2022 |
The Intercellular Communication Between Mesenchymal Stromal Cells and Hematopoietic Stem Cells Critically Depends on NF-κB Signalling in the Mesenchymal Stromal Cells.
Topics: Calcium; Calcium Ionophores; Calmodulin; Cell Communication; Cobalt; Hematopoietic Stem Cells; Mesenchymal Stem Cells; NF-kappa B | 2022 |
N-Acetylcysteine protects against cobalt chloride-induced endothelial dysfunction by enhancing glucose-6-phosphate dehydrogenase activity.
Topics: Acetylcysteine; Cobalt; Glucosephosphate Dehydrogenase; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Vascular Diseases | 2022 |
Enhanced electrochemical performance of the cobalt chloride carbonate hydroxide hydrate via micromorphology and phase transformation.
Topics: Carbonates; Chlorides; Cobalt; Electric Capacitance; Hydroxides | 2022 |
CoCl
Topics: Bone Morphogenetic Protein 2; Cell Hypoxia; Cells, Cultured; Cobalt; Fibroblasts; Fibrosis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Myringosclerosis; Osteogenesis; Vimentin | 2022 |
Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model.
Topics: Adenosine; Animals; Cardioplegic Solutions; Cobalt; Disease Models, Animal; Glucose; Humans; Ischemic Stroke; Lidocaine; Magnesium; Neuroblastoma; Neuroprotective Agents; Oxygen; Rats; Stroke | 2022 |
The effect of taxifolin on oxidative sciatic nerve damage induced by cobalt chloride in rats: a biochemical and histopathological evaluation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cobalt; Glutathione; Malondialdehyde; Oxidants; Oxidative Stress; Quercetin; Rats; Rats, Wistar; Sciatic Nerve; Superoxide Dismutase; Trace Elements | 2022 |
Cobalt Chloride-induced Hypoxia Can Lead SKBR3 and HEK293T Cell Lines toward Epithelial-mesenchymal Transition.
Topics: Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Hypoxia; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; RNA, Messenger; Vascular Endothelial Growth Factor A; Vimentin | 2022 |
Salidroside intensifies mitochondrial function of CoCl
Topics: Adenosine Triphosphate; Antioxidants; Apoptosis; Calcium; Cobalt; Humans; Hypoxia; Mitochondria; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Protons; Reactive Oxygen Species; Signal Transduction | 2023 |
Cobalt chloride exposure disturbs spindle assembly and decreases mouse oocyte development potential.
Topics: Animals; Cobalt; Female; Mammals; Meiosis; Mice; Oocytes; Spindle Apparatus | 2023 |
BNIP3-mediated autophagy via the mTOR/ULK1 pathway induces primordial follicle loss after ovarian tissue transplantation.
Topics: Animals; Autophagy; Cobalt; Female; Membrane Proteins; Mice; Mitochondrial Proteins; Ovarian Follicle; TOR Serine-Threonine Kinases | 2023 |
Development of cobalt-incorporated chitosan scaffold for regenerative potential in human dental pulp stem cells: An in vitro study.
Topics: Cell Differentiation; Chitosan; Cobalt; Dental Pulp; Humans; Regeneration; Stem Cells; Tissue Engineering; Tissue Scaffolds | 2023 |
A simplified protocol to induce hypoxia in a standard incubator: A focus on retinal cells.
Topics: Cell Hypoxia; Cell Line; Cobalt; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Oxygen | 2023 |