cobalt has been researched along with losartan potassium in 144 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 78 (54.17) | 18.7374 |
1990's | 42 (29.17) | 18.2507 |
2000's | 13 (9.03) | 29.6817 |
2010's | 10 (6.94) | 24.3611 |
2020's | 1 (0.69) | 2.80 |
Authors | Studies |
---|---|
Lange, RD | 1 |
Fisher, JW; Smith, RJ | 2 |
Fisher, JW; George, WJ; Rodgers, GM | 5 |
Boll, I | 1 |
gardner, FH; Gorshein, D; Reisner, EH | 1 |
Kubanek, B | 1 |
Mirand, EA; Murphy, GP; Varkarakis, MJ | 1 |
Camiscoli, JF; Gordon, AS; MacPherson, GG; Murphy, MJ | 1 |
Gross, J; Necas, E; Neuwirt, J | 1 |
Fried, W | 1 |
Brookins, J; Fisher, JW; Nakashima, J | 1 |
Bauer, C; Dittmer, J | 1 |
Beck, I; Caro, J; Costa-Giomi, P; Ramirez, S; Schuster, SJ | 1 |
Abraham, NG; Beru, N; Goldwasser, E; Hermine, O; Levere, RD; Lin, JH | 1 |
Jones, RW; Pugh, CW; Ratcliffe, PJ; Tan, CC | 1 |
Bunn, HF; Doweiko, J; Goldberg, MA; Imagawa, S | 1 |
Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP | 1 |
Buerk, DG; Di Giulio, C; Huang, WX; Lahiri, S; Mokashi, A | 1 |
Beru, N; Goldwasser, E; Smith, D | 1 |
Bunn, HF; Dunning, SP; Goldberg, MA | 2 |
Caro, J; Erslev, AJ; Kaufman, R; Nielsen, OJ; Schuster, SJ | 1 |
Badiavas, EV; Caro, J; Costa-Giomi, P; Erslev, AJ; Schuster, SJ; Weinmann, R | 1 |
Bauer, C; Jelkmann, W; Kurtz, A; Malmström, K; Pfuhl, A | 1 |
Chhabra, R; Datta, K; Singh, NK | 1 |
Beru, N; Goldwasser, E; Lacombe, C; McDonald, J | 1 |
Jelkmann, W | 1 |
Kazakov, VN; Krizhanovskaia, EV; Makarov, VP; Nefedov, VP; Tashenov, EK | 1 |
Kuratowska, Z | 1 |
Fisher, JW | 2 |
Fisher, JW; Heidger, PM; Ignarro, LJ; Smith, RJ | 1 |
Heinecke, G; Schulz, E | 1 |
Siciński, A | 1 |
Contrera, JF; Smith, RJ | 2 |
Banerjee, RK; Chowdhury, RR; Datta, AG | 1 |
Chowdhury, RR; Datta, AG | 1 |
Klucik, I; Palkovicová, M | 1 |
Thorling, EB | 1 |
Fisher, JW; Ignarro, LJ; Smith, RJ | 1 |
Moiseeva, OI | 1 |
Flanagan, P; Howard, D; Miller, ME; Stohlman, F | 1 |
Gurney, CW | 1 |
Groenewald, JH; Kenny, GM; Mirand, EA; Murphy, GP | 2 |
Bernier, GM; Conrad, ME; Felsher, BF; Schade, SG | 1 |
Goldwasser, E | 1 |
Naets, JP; Wittek, M | 2 |
Erslev, AJ; Thorling, EB | 1 |
Bernardelli, E; Osvaldo, A | 1 |
Fisher, JW; Langston, JW | 2 |
Mazur, A | 2 |
Curry, JL; Trentin, JJ; Wolf, N | 1 |
Pavlov, AD | 2 |
Fimian, WJ; Howard, D; Rencricca, NJ; Rizzoli, V; Solomon, J; Stohlman, F | 1 |
Bourgoignie, JJ; Donati, RM; Gallagher, NI; Kuhn, C; Perry, HM | 1 |
Boggs, DR; Cartwright, GE; Chervenick, PA; Marsh, JC; Wintrobe, MM | 1 |
Remmele, W | 1 |
Lindgren, I; Salmi, HA | 1 |
Atakhanov, EI; Iuldashev, UI | 1 |
Idel'son, LI | 1 |
Fried, W; Kilbridge, T | 1 |
Matsumoto, S | 2 |
Krehbiel, JD; Lund, JE; Weiss, DJ | 1 |
Beckman, B; Fisher, JW; George, WJ; Katsuoka, Y | 1 |
Bentley, DP | 1 |
Eckardt, KU; Gess, B; Göpfert, T; Kurtz, A | 2 |
Bauer, T; Caro, J; Minchenko, A; Salceda, S | 1 |
Ebert, BL; Firth, JD; Gleadle, JM; Ratcliffe, PJ | 1 |
Alibali, P; Gardner, A; Goldwasser, E | 1 |
Ebert, BL; Firth, JD; Pugh, CW; Ratcliffe, PJ | 1 |
Acker, H; Fandrey, J; Görlach, A; Holtermann, G | 1 |
Imagawa, S; Izumi, T; Miura, Y | 1 |
Blanchard, KL; Bunn, HF; Fandrey, J; Galson, DL; Goldberg, MA | 1 |
Semenza, GL; Wang, GL | 1 |
Goldberg, MA; Schneider, TJ | 1 |
Chang, TM; Koo, J | 1 |
Abraham, NG; Griffin, MO; Kappas, A; Levere, RD; Lutton, JD; Nishimura, M; Shibahara, S | 1 |
Maxwell, PH; Pugh, CW; Ratcliffe, PJ | 1 |
Imajoh-Ohmi, S; Kanegasaki, S; Ochiai, H; Tsuchiya, T; Ueda, M | 1 |
Ebert, BL; Gleadle, JM; Ratcliffe, PJ | 1 |
Bartlett, SM; Ebert, BL; Gleadle, JM; O'Rourke, JF; Poulton, J; Ratcliffe, PJ | 1 |
Buchwald, M; dos Santos, CC; Joenje, H; Kruyt, FA; Wevrick, R; Youssoufian, H | 1 |
Gess, B; Kurtz, A; Sandner, P; Wolf, K | 1 |
Blanchard, KL; Campbell, L; Hu, B; Wright, E | 1 |
Acker, H; Ehleben, W; Fandrey, J; Kummer, W; Porwol, T | 1 |
Acker, H; Ehleben, W; Fandrey, J; Frede, S; Jelkmann, W; Porwol, T | 1 |
Brink-Johnsen, T; Chen, J; Dunnack, LM; Leiter, JC; Ou, LC; Salceda, S; Schuster, SJ | 1 |
Prchal, JF; Prchal, JT; Stopka, T; Stopkova, P; Zivny, JH | 1 |
Acker, H; Ehleben, W; Fandrey, J; Porwol, T; Zierold, K | 1 |
Chandel, NS; Goldwasser, E; Maltepe, E; Mathieu, CE; Schumacker, PT; Simon, MC | 1 |
Agani, F; Semenza, GL | 1 |
Bauer, C; Gassmann, M; Marti, HH; Wenger, RH | 1 |
Bunn, HF; Goldberg, MA; Gu, J; Huang, LE; Willmore, WG | 1 |
Beru, N; Goldwasser, E; Mujais, SK; Pullman, TN | 1 |
Bradfield, CA; Chan, WK; Gu, YZ; Yao, G | 1 |
Daghman, NA; Elder, GE; Lappin, TR; Maxwell, AP; Savage, GA; Winter, PC | 1 |
Baraban, JM; Hall, D; Lin, KI; Marquis, JC; Miller, MP; O'Donovan, K; Ratan, RR; Ryu, H; Semenza, GL; Zaman, K | 1 |
Kambe, T; Masuda, S; Moon, SK; Nagao, M; Sasaki, R | 1 |
Bunn, HF; Horiguchi, H; Hradecky, P; Kayama, F; Oguma, E; Willmore, WG | 1 |
Bergeron, M; Jones, NM | 1 |
Cicutti, N; Kolar, F; Rakusan, K | 1 |
Buczko, W; Koda, M; Pawlak, D; Pawlak, S; Wolczynski, S | 1 |
FRIED, W; GOLDWASSER, E; JACOBSON, LO; PLZAK, LF | 1 |
BROWN, TE; MEINEKE, HA | 1 |
NAETS, JP | 1 |
FISHER, JW; SANZARI, NP | 1 |
COUCH, C; FISHER, JW; NIGHTINGALE, WO; ROH, BL | 1 |
FISHER, JW; ROH, BL; SHENEP, K | 1 |
AZUMA, M; NAKAO, K; SHIRAKURA, T | 1 |
JENSEN, K; THORLING, EB | 1 |
NORGELLO, H; SCHLUETER, RJ; WHITE, WF | 1 |
Funae, Y; Imaoka, S; Katsumura, S; Kubo, T; Maezawa, N; Osada, M | 1 |
Funae, Y; Imaoka, S; Osada, M | 1 |
Acs, G; Elder, DE; Fang, D; Herlyn, M; Kumar, SM; Xu, X | 1 |
Fujita, T; Inagi, R; Kojima, I; Matsumoto, M; Miyata, T; Nangaku, M; Ohse, T; Tanaka, T | 1 |
Francis, GL; Helms, A; Oakley, K; Patel, A; Tuttle, RM; Yates, CM | 1 |
Eckardt, KU; Nangaku, M | 1 |
Bansal, A; Ilavazhagan, G; Ram, MS; Shrivastava, K; Singh, SS | 1 |
Hirahara, F; Koizume, S; Miyagi, E; Miyagi, Y; Tsuchiya, E; Yokota, N | 1 |
Bansal, A; Saxena, S; Shukla, D; Singh, M; Thomas, P | 1 |
Brusco, A; Caltana, L; Girimonti, P; Lazarowski, A; Merelli, A; Ramos, AJ | 1 |
Chiang, CK; Fujita, T; Inagi, R; Nangaku, M; Tanaka, T | 1 |
Deng, DB; Mo, SJ; Zhang, XQ; Zhong, Q; Zhou, YF | 1 |
Chiang, CK; Inagi, R; Iwawaki, T; Nangaku, M; Tanaka, T | 1 |
Chamorro, ME; Nesse, AB; Vittori, DC; Wenker, SD | 1 |
Elliott, JP; Jones, SM; Novak, AE | 1 |
Befani, C; Georgoulias, P; Gkotinakou, IM; Hu, CJ; Liakos, P; Mylonis, I; Simos, G | 1 |
GARCIA, JF; SCHOOLEY, JC | 1 |
Gong, KR; Ji, XM; Lu, GW; Meister, EA; Shao, G; Wang, X; Yan, SC; Zhang, YB | 1 |
Chen, D; Chen, Z; Dai, C; Han, Z; He, F; Li, Y; Tan, R; Tian, H; Wang, G; Wang, M; Wei, L; Yang, B; Yang, H; Zhang, B | 1 |
Knoop, A; Planitz, P; Thevis, M; Wüst, B | 1 |
11 review(s) available for cobalt and losartan potassium
Article | Year |
---|---|
Erythrocytosis associated with normal blood-gas values.
Topics: Alkylating Agents; Androgens; Blood; Bloodletting; Carbon Dioxide; Cobalt; Erythropoiesis; Erythropoietin; Humans; Hydrogen-Ion Concentration; Oxygen; Phosphorus Radioisotopes; Polycythemia; Polycythemia Vera | 1976 |
The role of renal adenosine 3',5'-monophosphate in the control of erythropoietin production.
Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Bucladesine; Cobalt; Cyclic AMP; Cyclic GMP; Enzyme Activation; Erythropoietin; Humans; Hypoxia; Kidney; Kidney Cortex; Mice; Phosphoric Diester Hydrolases; Prostaglandins; Protein Kinases; Rats; Stimulation, Chemical; Theophylline | 1975 |
Erythropoietin and the kidney.
Topics: Anemia; Animals; Cobalt; Dactinomycin; Erythropoiesis; Erythropoietin; Hormones; Humans; Kidney; Kidney Failure, Chronic; Mice; Oxygen Consumption; Polycythemia; Rats | 1975 |
Regulation of erythropoietin gene expression.
Topics: Anemia; Animals; Blotting, Northern; Cobalt; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; Mice; Rats; Restriction Mapping; RNA; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1991 |
Renal erythropoietin: properties and production.
Topics: Animals; Cobalt; Erythropoiesis; Erythropoietin; Hormones; Humans; Hypoxia; Kidney; Oxygen | 1986 |
Erythropoietin: pharmacology, biogenesis and control of production.
Topics: Adrenal Cortex Hormones; Androgens; Anemia; Angiotensin II; Chemical Phenomena; Chemistry; Cobalt; Cyclic AMP; Erythropoiesis; Erythropoietin; Humans; Juxtaglomerular Apparatus; Kidney; Nervous System Physiological Phenomena; Norepinephrine; Oxygen; Polycythemia; Prostaglandins; Serotonin; Thyroid Hormones; Vasopressins | 1972 |
[Treatment of anemia in renal failure].
Topics: Acute Kidney Injury; Androgens; Anemia; Blood Transfusion; Cobalt; Erythropoietin; Female; Humans; Iron; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Renal Dialysis; Sex Factors | 1974 |
Erythropoietin.
Topics: Anemia; Animals; Cobalt; Erythropoiesis; Erythropoietin; Humans; Hypophysectomy; Kidney; Mice; Pituitary Gland; Rabbits; Rats | 1968 |
Biochemical control of erythroid cell development.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Differentiation; Cobalt; Dactinomycin; Erythropoiesis; Erythropoietin; Genes, Regulator; Glucosamine; Glycols; Hematopoietic Stem Cells; Heme; Hemoglobins; In Vitro Techniques; Models, Biological; Pituitary Gland; Rats; Reticulocytes; RNA; Steroids; Thyroid Hormones | 1966 |
Cis elements that regulate the erythropoietin gene.
Topics: Animals; Cell Line; Cobalt; Erythropoietin; Exons; Gene Expression Regulation; Humans; Mice; Oxygen; Regulatory Sequences, Nucleic Acid; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transfection | 1994 |
Hypoxia and the HIF system in kidney disease.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cobalt; Erythropoietin; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Kidney; Kidney Diseases; Oxygen; Signal Transduction | 2007 |
133 other study(ies) available for cobalt and losartan potassium
Article | Year |
---|---|
Neutral protease activity and erythropoietin production in the rat after cobalt administration.
Topics: Animals; Cathepsins; Cobalt; Erythropoietin; Hydrogen-Ion Concentration; Isoflurophate; Kidney; Male; Mitochondria; Peptide Hydrolases; Rats; Time Factors | 1976 |
Renal cyclic GMP and cholinergic mechanisms in erythropoietin production.
Topics: Acetylcholine; Animals; Atropine; Cobalt; Cyclic GMP; Drug Synergism; Erythropoietin; Glucuronidase; Kidney; Lysosomes; Male; Physostigmine; Rats | 1975 |
[Regulation of the human erythropoietic proliferation pool by the microenvironment (author's transl)].
Topics: Androgens; Cobalt; Culture Media; Cyclic AMP; Erythropoiesis; Erythropoietin; Etiocholanolone; Folic Acid; Hematopoiesis; Humans; Mitosis; Polycythemia Vera | 1978 |
Tissue culture of bone marrow. V. Effect of 5Beta(H) steroids and cyclic AMP on heme synthesis.
Topics: Androstanes; Bone Marrow; Bucladesine; Calcium; Cobalt; Culture Techniques; Cyclic AMP; Cyproterone; Drug Synergism; Erythropoiesis; Erythropoietin; Heme; Humans; Hydroxysteroids; Immune Sera; Ketosteroids; Pregnanediones; Pregnanes; Pregnanolone; Stimulation, Chemical; Theophylline | 1975 |
[Conservative treatment of infection and tumor anemia].
Topics: Anemia; Blood Transfusion; Chlorides; Cobalt; Collagen Diseases; Erythropoietin; Humans; Iron; Neoplasms; Testosterone | 1979 |
The response of the juxtaglomerular apparatus to stimuli effecting renin or erythropoietin release in canine renal allografts.
Topics: Animals; Azathioprine; Blood Pressure; Cobalt; Diet; Dogs; Erythropoietin; Female; Graft Rejection; Hypoxia; Juxtaglomerular Apparatus; Kidney Transplantation; Male; Renin; Sodium Chloride; Testosterone; Transplantation, Homologous | 1976 |
Erythropoietin in renal and hepatic lymph of conscious ewes.
Topics: Anemia, Hemolytic; Animals; Cobalt; Erythropoietin; Female; Hydronephrosis; Kidney; Liver; Lymph; Mice; Phenylhydrazines; Renal Artery Obstruction; Sheep | 1977 |
Species specificity of guinea pig erythropoietin.
Topics: Animals; Bloodletting; Carbon Monoxide Poisoning; Cobalt; Erythropoietin; Female; Guinea Pigs; Hypoxia; Kidney; Mice; Nephrectomy; Rats; Species Specificity | 1976 |
Characterization of erythropoietin production in a hepatocellular carcinoma cell line.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Hepatocellular; Cobalt; Colforsin; Cyclic AMP; Erythropoietin; Humans; Hypoxia; Liver Neoplasms; Tumor Cells, Cultured | 1992 |
Inhibitory effect of zinc on stimulated erythropoietin synthesis in HepG2 cells.
Topics: Blotting, Northern; Cadmium; Carcinoma, Hepatocellular; Cations, Divalent; Cell Hypoxia; Cobalt; Depression, Chemical; Erythropoietin; Nickel; RNA, Messenger; Tumor Cells, Cultured; Zinc | 1992 |
Co-regulation of heme oxygenase and erythropoietin genes.
Topics: Animals; Base Sequence; Blotting, Northern; Cobalt; Erythropoietin; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Kidney; Kinetics; Male; Molecular Sequence Data; Polydeoxyribonucleotides; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1991 |
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.
Topics: Animals; Base Sequence; Cell Line; CHO Cells; Cloning, Molecular; Cobalt; Cricetinae; Cyanides; Deoxyglucose; Enhancer Elements, Genetic; Erythropoietin; Escherichia coli; Gene Expression Regulation; Globins; Male; Mice; Molecular Sequence Data; Oxygen; Plasmids; Recombinant Fusion Proteins; Restriction Mapping; RNA, Messenger; Transcription, Genetic; Transfection | 1991 |
Regulatory elements of the erythropoietin gene.
Topics: Animals; Cell Line; Chlorocebus aethiops; Cobalt; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; In Vitro Techniques; Regulatory Sequences, Nucleic Acid; Transcription, Genetic; Transfection | 1991 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured | 1990 |
Cobalt stimulates carotid body chemoreceptors.
Topics: Animals; Calcium; Carotid Body; Cats; Chemoreceptor Cells; Cobalt; Electrophysiology; Erythropoietin; Hypoxia; Oxygen | 1990 |
Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein.
Topics: Animals; Base Sequence; Cell Nucleus; Cobalt; Erythropoietin; Female; Gene Expression Regulation; Humans; Kidney; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligonucleotide Probes; Reference Values; Ribonucleoproteins; Sequence Homology, Nucleic Acid | 1990 |
Oxygen sensing and erythropoietin gene regulation in a human hepatoma cell line.
Topics: Animals; Biological Assay; Blotting, Northern; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Erythropoietin; Gene Expression Regulation, Neoplastic; Hemeproteins; Humans; Liver Neoplasms; Manganese; Mice; Neoplasm Proteins; Nickel; Oxygen; Radioimmunoassay; RNA, Messenger; Second Messenger Systems; Tumor Cells, Cultured | 1989 |
Regulation of erythropoietin production in a human hepatoblastoma cell line.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cobalt; Cricetinae; Erythropoietin; Glycosylation; Humans; Hypoxia; Liver Neoplasms; Protein Processing, Post-Translational; RNA, Messenger; Transfection; Tumor Cells, Cultured; Tunicamycin | 1987 |
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.
Topics: Anaerobiosis; Carbon Monoxide; Carcinoma, Hepatocellular; Cell Line; Cobalt; Cycloheximide; Erythropoietin; Gene Expression Regulation; Genes; Hemeproteins; Humans; Iron; Liver Neoplasms; Manganese; Nickel; Transcription, Genetic | 1988 |
Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure.
Topics: Animals; Cobalt; Erythropoietin; Gene Expression Regulation; Hypoxia; Kidney; Male; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1989 |
Erythropoietin production by fetal mouse liver cells in response to hypoxia and adenylate cyclase stimulation.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Cobalt; Colforsin; Cyclic AMP; Enzyme Activation; Erythropoietin; Isoproterenol; Kinetics; Lactates; Lactic Acid; Liver; Mice; Oxygen | 1986 |
Induction of L-alanine:4,5-dioxovalerate transaminase by phenylhydrazine is associated with depletion of heme level.
Topics: Anemia; Animals; Cobalt; Dactinomycin; Erythropoietin; Hematocrit; Heme; Immune Sera; Immunodiffusion; Kidney; Kinetics; Liver; Male; Phenylhydrazines; Rats; Rats, Inbred Strains; Transaminases | 1986 |
Expression of the erythropoietin gene.
Topics: Animals; Cobalt; Erythropoietin; Gene Expression Regulation; Hemorrhage; Kidney; Leukemia, Erythroblastic, Acute; Liver; Male; Rats; RNA, Messenger; Time Factors | 1986 |
[Assessment of the erythropoietin-producing function of the kidney and liver under controlled perfusion].
Topics: Animals; Cobalt; Dogs; Erythropoiesis; Erythropoietin; Hemorrhage; Kidney; Liver; Male; Mice; Mice, Inbred CBA; Perfusion; Polycythemia | 1986 |
The renal mechanism of the formation and inactivation of erythropoietin.
Topics: Alpha-Globulins; Androgens; Animals; Biological Assay; Cobalt; Erythrocytes; Erythropoietin; Hematocrit; Hypothalamus; Hypoxia; Iron Isotopes; Kidney; Liver; Oxygen; Rabbits; Rats | 1968 |
Increased kidney cyclic AMP levels and erythropoietin production following cobalt administration.
Topics: Animals; Butyrates; Cobalt; Cyclic AMP; Erythropoiesis; Erythropoietin; Hypoxia; Iron; Iron Isotopes; Kidney; Male; Polycythemia; Rats; Stimulation, Chemical | 1972 |
Effects of cobalt on the renal erythropoietic factor and kidney hydrolase activity in the rat.
Topics: Acid Phosphatase; Alkaline Phosphatase; Aminocaproates; Animals; Aprotinin; Blood Proteins; Cathepsins; Cobalt; Electron Transport Complex IV; Erythrocyte Count; Erythropoiesis; Erythropoietin; Female; Iron Radioisotopes; Isoflurophate; Kidney; Male; Mercaptoethanol; Mice; Mitochondria; Polycythemia; Propionates; Rats; Sulfhydryl Compounds; Thiocarbamates | 1973 |
Elevation of renal cyclic GMP concentrations and plasma lysosomal enzyme activity following cobalt treatment in rats.
Topics: Acid Phosphatase; Aluminum; Animals; Chromatography; Chromatography, Ion Exchange; Cobalt; Cyclic GMP; Erythropoietin; Glucuronidase; Kidney; Lysosomes; Male; Nephrectomy; Radioimmunoassay; Rats; Time Factors | 1974 |
Lactate stimulation of renal cortical adenylate cyclase: a mechanism for erythropoietin production following cobalt treatment or hypoxia.
Topics: Adenylyl Cyclases; Animals; Cobalt; Cyclic AMP; Erythropoiesis; Erythropoietin; Hypoxia; Iron; Iron Radioisotopes; Kidney Cortex; Kidney Medulla; Lactates; Male; NAD; Phosphorus Radioisotopes; Polycythemia; Pyruvates; Rats; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors; Tritium | 1974 |
Lysosomal enzyme release in vivo: an evaluation of the mechanism of cobalt polycythemia.
Topics: Acid Phosphatase; Animals; Cobalt; Erythropoiesis; Erythropoietin; Female; Glucuronidase; Histocytochemistry; Hypoxia; Iron; Kidney; Lysosomes; Male; Manganese; Membranes; Mice; Microscopy, Electron; Mitochondria; Nephrectomy; Nickel; Polycythemia; Rats | 1974 |
[Prevention and therapy of renal anemia].
Topics: Anemia, Hemolytic; Blood Transfusion; Chlorides; Cobalt; Erythropoietin; Follow-Up Studies; Hematocrit; Humans; Iron; Kidney Failure, Chronic; Kidney Transplantation; Renal Dialysis; Testosterone; Transplantation, Homologous | 1973 |
The effect of cobalt on erythropoietin and kininogen levels in rat plasma.
Topics: Animals; Atmosphere Exposure Chambers; Biological Assay; Chlorides; Cobalt; Erythrocytes; Erythropoietin; Female; Injections, Subcutaneous; Iron; Iron Isotopes; Kininogens; Kinins; Male; Mice; Polycythemia; Protein Precursors; Rats; Time Factors; Uterus | 1972 |
Effect of erythropoietin on the peroxidase and tyrosine-iodinase activity of mouse thyroid and submaxillary gland.
Topics: Animals; Cobalt; Cobalt Isotopes; Enzyme Induction; Erythrocytes; Erythropoietin; Iron; Iron Isotopes; Kidney; Male; Mice; Monoiodotyrosine; Neuraminidase; Peroxidases; Rats; Sheep; Starvation; Submandibular Gland; Thyroid Gland; Vitamin B 12 | 1973 |
Studies on the in vitro formation of erythropoietin in sheep kidney medulla and the effect of cobalt thereon.
Topics: Amino Acids; Animals; Carbon Isotopes; Cobalt; Cycloheximide; Dactinomycin; Drug Stability; Electrophoresis, Disc; Erythropoietin; Hot Temperature; In Vitro Techniques; Juxtaglomerular Apparatus; Kidney; Kidney Cortex; Kidney Medulla; Phenylalanine; Precipitin Tests; Sheep | 1973 |
[Level of erythropoietin in the serum of employees of the hydrometallurgical production of cobalt].
Topics: Cobalt; Erythropoietin; Humans; Metallurgy; Occupational Diseases | 1973 |
A comparison of the cobalt, methylene blue, zinc, arsenite and amino triazole effect on erythropoietin production.
Topics: Animals; Arsenic; Biological Assay; Cobalt; Erythropoietin; Female; Hypoxia; Iron; Iron Isotopes; Male; Methylene Blue; Mice; Polycythemia; Rabbits; Stimulation, Chemical; Triazoles; Zinc | 1973 |
Lysosomal enzyme release: a possible mechanism of action of cobalt as an erythropoietic stimulant.
Topics: Acid Phosphatase; Animals; Cobalt; Erythropoiesis; Erythropoietin; Glucuronidase; In Vitro Techniques; Iron; Kidney; Lysosomes; Male; Manganese; Membranes; Nickel; Rats; Time Factors | 1974 |
[Erythropoietic properties of a homogenate of kidney and its subcellular fractions].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Cobalt; Depression, Chemical; Erythropoietin; Hemorrhage; Kidney; Microsomes; Mitochondria; Mitosis; Rabbits; Rats; Stimulation, Chemical; Tissue Extracts | 1974 |
Mechanism of erythropoietin production by cobaltous chloride.
Topics: Alkalosis, Respiratory; Animals; Carbon Dioxide; Carboxyhemoglobin; Chlorides; Cobalt; Dose-Response Relationship, Drug; Erythropoietin; Female; Hydrogen-Ion Concentration; Iron Radioisotopes; Male; Nephrectomy; Oxygen; Partial Pressure; Rats; Spectrophotometry | 1974 |
Cobalt-induced alterations in plasma proteins, proteases and kinin system of the rat.
Topics: Animals; Arginine; Blood Proteins; Bradykinin; Caseins; Cobalt; Erythropoietin; Esterases; Female; Hydrolysis; Kininogens; Kinins; Male; Peptide Hydrolases; Rats; Stimulation, Chemical; Time Factors; Uterus | 1974 |
Erythropoietin activity in autotransplanted canine kidneys.
Topics: Animals; Cobalt; Dogs; Erythropoietin; Female; Hemorrhage; Hypoxia; Iron Isotopes; Kidney; Kidney Transplantation; Male; Mice; Testosterone; Transplantation, Autologous | 1969 |
Response of renal allografts to erythropoietic stimuli in the presence of immunosuppression.
Topics: Androgens; Animals; Azathioprine; Blood Urea Nitrogen; Cobalt; Dogs; Erythropoiesis; Erythropoietin; Female; Hematocrit; Hypoxia; Immunosuppressive Agents; Kidney Transplantation; Leukocyte Count; Male; Tissue Extracts; Urination | 1970 |
Interrelationship of cobalt and iron absorption.
Topics: Animals; Ascorbic Acid; Cobalt; Cobalt Isotopes; Deficiency Diseases; Endotoxins; Erythropoietin; Escherichia coli; Ferritins; Immunoassay; Intestinal Absorption; Iron; Iron Isotopes; Iron-Dextran Complex; Male; Rabbits; Rats | 1970 |
Effect of erythroid hyperplasia on the disappearance rate of erythropoietin in the dog.
Topics: Animals; Blood Cell Count; Bone Marrow Diseases; Bone Marrow Examination; Cobalt; Cobalt Isotopes; Dogs; Erythrocytes; Erythropoiesis; Erythropoietin; Female; Hematocrit; Hemoglobinometry; Hyperplasia; Male; Mice; Nephrectomy; Phenylhydrazines; Reticulocytes | 1968 |
The effect of some erythropoietic agents on the 'tissue' tension of oxygen.
Topics: Animals; Blood Transfusion; Cobalt; Erythropoiesis; Erythropoietin; Female; Hemolysis; Iron; Iron Isotopes; Male; Nandrolone; Norethandrolone; Oxygen; Oxygen Consumption; Partial Pressure; Rats; Testosterone | 1972 |
[Research on the pathogenesis of avian erythremia].
Topics: Animals; Chick Embryo; Cobalt; Erythropoietin; Leukemia, Erythroblastic, Acute; Nandrolone; Poultry; Prednisone; Vitamin B 12 | 1965 |
Effects of testosterone, cobalt and hypoxia on erythropoietin production in the isolated perfused dog kidney.
Topics: Animals; Biological Assay; Cobalt; Dogs; Erythrocytes; Erythropoietin; Female; Hypoxia; Iron; Iron Isotopes; Kidney; Kidney Glomerulus; Male; Mice; Oximetry; Oxygen; Perfusion; Testosterone | 1968 |
Role of the spleen in iron metabolism.
Topics: Animals; Bone Marrow; Carbon Isotopes; Cobalt; Enzymes; Erythrocytes; Erythropoietin; Glycine; Heme; Hemorrhage; Histones; Iron; Iron Isotopes; Liver; Lyases; Lymphoma, Non-Hodgkin; Lysine; Phenylhydrazines; Porphyrins; Radiation Effects; Rats; Reticulocytes; Spleen | 1969 |
Hemopoietic spleen colony studies. II. Erythropoiesis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cobalt; Erythropoiesis; Erythropoietin; Mice; Polycythemia; Radiation Effects; Sodium Chloride; Spleen | 1967 |
[Effect of erythropoietic stimuli on ribonucleic acid synthesis in bone marrow].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Cobalt; DNA; Enzyme Repression; Erythropoiesis; Erythropoietin; Hemorrhage; Phenylhydrazines; Phosphorus; Phosphorus Isotopes; Rabbits; Ribosomes; RNA; RNA, Transfer; Stimulation, Chemical | 1969 |
Molecular aspect of action of endogenous erythropoietin. The effects of erythropoietic stimuli on synthesis of ribonucleic acids in rabbit bone marrow.
Topics: Animals; Bloodletting; Bone Marrow; Cobalt; DNA; Erythrocyte Count; Erythropoiesis; Erythropoietin; Femur; Forelimb; Hematocrit; Hemoglobins; Iron Isotopes; Phenylhydrazines; Phosphates; Phosphorus Isotopes; Rabbits; Reticulocytes; Ribosomes; RNA; RNA, Transfer; Stimulation, Chemical; Templates, Genetic; Tibia; Time Factors | 1969 |
The effect of testosterone on erythropoiesis.
Topics: Animals; Cobalt; Erythropoiesis; Erythropoietin; Iron Isotopes; Kidney; Nephrectomy; Polycythemia; Rats; Testosterone; Tissue Extracts; Ureter | 1969 |
Dissociation of circulating renin and erythropoietin in rats.
Topics: Animals; Chlorides; Cobalt; Erythropoietin; Hypoxia; Injections, Intraperitoneal; Oxygen Consumption; Polythiazide; Rats; Renin; Sodium Chloride; Water-Electrolyte Balance | 1968 |
Factors influencing hematopoietic spleen colony formation in irradiated mice. IV. The effect of erythropoietic stimuli.
Topics: Animals; Cobalt; Culture Techniques; Erythropoiesis; Erythropoietin; Hemorrhage; Iron; Mice; Organ Size; Radiation Effects; Spleen; Splenectomy; Testosterone | 1968 |
Metabolism of the stimulated rat spleen. I. Ferrochelatase activity as an index of tissue erythropoiesis.
Topics: Animals; Bone Marrow; Carbon Isotopes; Carcinoma 256, Walker; Chlorides; Cobalt; Dactinomycin; Erythrocytes; Erythropoiesis; Erythropoietin; Female; Ferritins; Glycine; Hemoglobins; Iron Isotopes; Liver; Lyases; Phenylhydrazines; Rats; RNA; Spleen; Stimulation, Chemical | 1968 |
[Erythropoietin].
Topics: Adult; Anemia; Animals; Chickens; Child, Preschool; Cobalt; Erythropoiesis; Erythropoietin; Gonadal Steroid Hormones; Humans; Infant, Newborn; Juxtaglomerular Apparatus; Mice; Rabbits; Rats | 1968 |
Cobalt in the human organism. Experiments on retention of 60-Co in patients with normal and glomerulonephritic kidneys.
Topics: Adult; Aged; Autoradiography; Cobalt; Cobalt Isotopes; Erythropoiesis; Erythropoietin; Female; Glomerulonephritis; Humans; Kidney; Kidney Function Tests; Liver; Male; Middle Aged | 1968 |
[Hemopoetic factors in anemias of gastro-intestinal origin].
Topics: Anemia; Cobalt; Erythropoietin; Gastric Juice; Gastrointestinal Diseases; Humans; Iron; Mucoproteins; Vitamin B 12 | 1968 |
[Normal and pathological hematopoiesis and porphyrin formation].
Topics: Anemia, Sideroblastic; Animals; Ascorbic Acid; Cobalt; Erythropoiesis; Erythropoietin; Humans; Lead Poisoning; Porphyrias; Porphyrins; Rats | 1968 |
Effect of testosterone and of cobalt on erythropoietin production by anephric rats.
Topics: Animals; Biological Assay; Blood Volume; Body Weight; Cobalt; Erythropoietin; Female; Hypoxia; Iron Isotopes; Kidney; Nephrectomy; Rats; Testosterone | 1969 |
Effect of erythroid hyperplasia on utilization of erythropoietin.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Cobalt; Dogs; Erythropoietin; Hyperplasia; In Vitro Techniques; Nephrectomy | 1965 |
[Erythropoiesis and cobalt. I. Studies on erythropoiesis stimulating mechanism of cobalt].
Topics: Animals; Cobalt; Erythrocytes; Erythropoiesis; Erythropoietin; In Vitro Techniques; Injections, Intramuscular; Iron Isotopes; Rabbits; Rats | 1965 |
[Erythropoiesis and cobalt. II. Studies on the mechanism of erythropoietin production by cobalt].
Topics: Animals; Cobalt; Erythrocytes; Erythropoiesis; Erythropoietin; In Vitro Techniques; Injections, Intramuscular; Nephrectomy; Rabbits; Rats | 1965 |
The influence of hypoxemia and cobalt on erythropoietin production in the isolated perfused dog kidney.
Topics: Animals; Cobalt; Dogs; Erythropoietin; Hypoxia; Kidney; Perfusion | 1967 |
Studies of the pathogenesis of anemia of inflammation: mechanism of impaired erythropoiesis.
Topics: Anemia; Animals; Cat Diseases; Cats; Cobalt; Erythrocyte Count; Erythropoiesis; Erythropoietin; Ferric Compounds; Hematocrit; Inflammation; Iron; Reticulocytes; Time Factors; Turpentine | 1983 |
Increased levels of erythropoietin in kidney extracts of rats treated with cobalt and hypoxia.
Topics: Animals; Cobalt; Erythropoiesis; Erythropoietin; Hypoxia; Kidney; Male; Rats; Rats, Inbred Strains | 1983 |
Anaemia and chronic disease.
Topics: Anemia; Chronic Disease; Cobalt; Erythropoietin; Ferritins; Humans; Infusions, Parenteral; Intestinal Mucosa; Iron; Kinetics; Mononuclear Phagocyte System; Protoporphyrins | 1982 |
Cobalt exerts opposite effects on erythropoietin gene expression in rat hepatocytes in vivo and in vitro.
Topics: Animals; Animals, Newborn; Carbon Monoxide; Cells, Cultured; Cobalt; Erythropoietin; Gene Expression; Hypoxia; In Vitro Techniques; Liver; Male; Oxygen; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Hypoxia regulatory elements of the human vascular endothelial growth factor gene.
Topics: Base Sequence; Cell Hypoxia; Cobalt; DNA; Endothelial Growth Factors; Enhancer Elements, Genetic; Erythropoietin; Genes, Regulator; HeLa Cells; Humans; Hypoxia; Lymphokines; Molecular Sequence Data; Neovascularization, Pathologic; Sequence Homology, Nucleic Acid; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1994 |
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents.
Topics: Angiogenesis Inducing Agents; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Chelating Agents; Cobalt; Deferoxamine; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation, Neoplastic; Growth Substances; Humans; Liver Neoplasms; Lymphokines; Molecular Sequence Data; Neovascularization, Pathologic; Placenta Growth Factor; Platelet-Derived Growth Factor; Pregnancy Proteins; RNA, Messenger; RNA, Small Nuclear; Transforming Growth Factor beta; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1995 |
Differential inhibition by iodonium compounds of induced erythropoietin expression.
Topics: Biphenyl Compounds; Cobalt; Erythropoietin; Onium Compounds; Tumor Cells, Cultured | 1995 |
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Cloning, Molecular; Cobalt; Cyanides; Cycloheximide; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Isoenzymes; L Cells; L-Lactate Dehydrogenase; Liver Neoplasms; Mice; Molecular Sequence Data; Oxygen; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sequence Deletion; Sequence Homology, Nucleic Acid; TATA Box; Transfection; Tumor Cells, Cultured | 1994 |
Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid culture.
Topics: Cells, Cultured; Cobalt; Cytochromes; Erythropoietin; Hydrogen Peroxide; Oxidation-Reduction; Signal Transduction | 1994 |
Positive and negative regulation of the erythropoietin gene.
Topics: Base Sequence; Binding Sites; Cell Line; Cobalt; DNA Primers; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; In Vitro Techniques; Molecular Sequence Data; Nuclear Proteins; Nucleic Acid Conformation; Oligonucleotides; Promoter Regions, Genetic; RNA, Messenger | 1994 |
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
Topics: Base Sequence; Cell Hypoxia; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Oligonucleotide Probes; RNA, Neoplasm; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1993 |
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
Topics: Animals; Cobalt; Cycloheximide; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation; Genes, fos; Genes, jun; Heme; Humans; Hypoxia; In Vitro Techniques; Lymphokines; Oxygen; Rats; RNA, Messenger; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1994 |
Secretion of erythropoietin from microencapsulated rat kidney cells: preliminary results.
Topics: Alginates; Animals; Artificial Organs; Cell Survival; Cobalt; Culture Media; Diffusion Chambers, Culture; Drug Compounding; Erythropoietin; Kidney; Membranes, Artificial; Polylysine; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1993 |
Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.
Topics: Carcinoma, Hepatocellular; Cobalt; Erythropoietin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Humans; Liver Neoplasms; Metalloporphyrins; Protoporphyrins; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.
Topics: Animals; Cell Hypoxia; Cell Line; Cobalt; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation; Humans; Organ Specificity; Oxygen; Plasmids; Restriction Mapping; Transfection; Tumor Cells, Cultured | 1993 |
Erythropoietin 5'-flanking sequence-binding protein induced during hypoxia and cobalt exposure.
Topics: Anemia; Animals; Base Sequence; Cell Line; Chromatography, Affinity; Cobalt; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Gene Expression; Humans; Hypoxia; Kidney; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data | 1993 |
Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing.
Topics: Base Sequence; Biphenyl Compounds; Cobalt; Deferoxamine; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Onium Compounds; Oxygen; Transcription Factors; Tumor Cells, Cultured | 1995 |
Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin.
Topics: Base Sequence; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Energy Metabolism; Erythropoietin; Gene Expression Regulation; Glycolysis; HeLa Cells; Humans; Isoenzymes; Mitochondria; Molecular Sequence Data; Monosaccharide Transport Proteins; Oligonucleotide Probes; RNA, Messenger; Siderophores | 1996 |
Expression of the Fanconi anemia gene FAC in human cell lines: lack of effect of oxygen tension.
Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Hypoxia; Cell Line, Transformed; Cobalt; DNA-Binding Proteins; Erythropoietin; Fanconi Anemia; Fanconi Anemia Complementation Group C Protein; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphocytes; Nuclear Proteins; Oxygen; Protein Biosynthesis; Proteins; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Hypoxia signalling in the control of erythropoietin gene expression in rat hepatocytes.
Topics: Animals; Catalase; Cell Hypoxia; Cells, Cultured; Cobalt; Cycloheximide; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression Regulation; Hydrogen Peroxide; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Liver; Male; Nuclear Proteins; Oxygen; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA; Signal Transduction; Transcription Factors | 1996 |
Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo.
Topics: Animals; Base Sequence; Carbon Monoxide; Cobalt; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation; Hypoxia; In Vitro Techniques; Lymphokines; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1996 |
In vivo analysis of DNA-protein interactions on the human erythropoietin enhancer.
Topics: Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; DNA; DNA Footprinting; DNA Methylation; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Genes; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Polymerase Chain Reaction; Trans-Activators; Tumor Cells, Cultured | 1997 |
Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells.
Topics: Cell Line; Cobalt; Cytochromes; Deferoxamine; Erythropoietin; Fluorescent Dyes; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Models, Molecular; NADPH Oxidases; Oxygen; Oxygen Consumption; Reactive Oxygen Species; Rhodamine 123; Rhodamines | 1997 |
Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species.
Topics: Cell Line; Cobalt; Deferoxamine; Erythropoietin; Humans; Hydrogen Peroxide; NADP; Reactive Oxygen Species; Signal Transduction | 1997 |
Polycythemic responses to hypoxia: molecular and genetic mechanisms of chronic mountain sickness.
Topics: Altitude Sickness; Animals; Blood Gas Analysis; Blotting, Northern; Chronic Disease; Cobalt; Erythropoietin; Feedback; Gene Expression Regulation; Hypoxia; Kidney; Kidney Function Tests; Male; Polycythemia; Rats; Rats, Sprague-Dawley; Ribonucleases | 1998 |
Human hematopoietic progenitors express erythropoietin.
Topics: Adult; Antigens, CD34; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cells, Cultured; Cobalt; Culture Media, Serum-Free; Enzyme-Linked Immunosorbent Assay; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Molecular Sequence Data; Peptides; Receptors, Erythropoietin; RNA, Messenger; Tumor Cells, Cultured | 1998 |
The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cell Compartmentation; Cobalt; Drug Interactions; Electron Probe Microanalysis; Erythropoietin; Free Radical Scavengers; Hemeproteins; Humans; Hydrogen Peroxide; Iron; Liver; Metals, Heavy; Microscopy, Confocal; Nickel; Oxygen; Oxygen Consumption; Reactive Oxygen Species; Signal Transduction; Spectrophotometry; Tumor Cells, Cultured | 1998 |
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
Topics: Adenosine Triphosphate; Antioxidants; Azoles; Cell Hypoxia; Cell Line; Cobalt; DNA-Binding Proteins; DNA, Mitochondrial; Endothelial Growth Factors; Erythropoietin; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Isoindoles; Lymphokines; Mitochondria, Liver; Nuclear Proteins; Organoselenium Compounds; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Thiocarbamates; Transcription Factors; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
Topics: Animals; Antimutagenic Agents; Base Sequence; Cell Hypoxia; Chelating Agents; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Erythropoietin; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Lymphokines; Mersalyl; Nuclear Proteins; Phosphopyruvate Hydratase; Rats; Receptor, IGF Type 1; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Optimal erythropoietin expression in human hepatoma cell lines requires activation of multiple signalling pathways.
Topics: Carcinoma, Hepatocellular; Cell Count; Cell Hypoxia; Cobalt; Dexamethasone; Erythropoietin; Humans; Interleukin-6; Liver Neoplasms; Oxygen; Signal Transduction | 1998 |
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carbon Monoxide; Cell Hypoxia; Cell Line; Cobalt; Cyclic GMP; Cysteine; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nitric Oxide; Nitroprusside; Nuclear Proteins; Oxygen; Receptors, Aryl Hydrocarbon; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transfection | 1999 |
Erythropoietin is produced by tubular cells of the rat kidney.
Topics: Adenosine Triphosphatases; Animals; Antimutagenic Agents; Blotting, Southern; Cobalt; Erythropoietin; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase | 1999 |
Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation.
Topics: Base Sequence; Binding, Competitive; Cobalt; Cytochrome P-450 CYP1A1; Dioxins; DNA; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Promoter Regions, Genetic; Receptor Cross-Talk; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Cells, Cultured | 1999 |
Erythropoietin production: evidence for multiple oxygen sensing pathways.
Topics: Chelating Agents; Cobalt; Deferoxamine; Erythropoietin; Humans; Iron Chelating Agents; Oxygen; Partial Pressure; Reactive Oxygen Species; Sulfhydryl Reagents; Tumor Cells, Cultured | 1999 |
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and ery
Topics: Activating Transcription Factor 1; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Chelating Agents; Cobalt; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deferoxamine; DNA-Binding Proteins; Enzyme Induction; Erythropoietin; Fetus; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Glutathione; Glycolysis; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate Dehydrogenase; Mimosine; Neurons; Neuroprotective Agents; Nuclear Proteins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transcription Factors | 1999 |
A new biological strategy for high productivity of recombinant proteins in animal cells by the use of hypoxia-response enhancer.
Topics: Animals; Base Sequence; Carbohydrates; Cell Hypoxia; CHO Cells; Cobalt; Cricetinae; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Nuclear Proteins; Oxygen; Promoter Regions, Genetic; Protein Engineering; Recombinant Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2000 |
Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications.
Topics: Cadmium; Cell Survival; Cisplatin; Cobalt; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Environmental Exposure; Erythropoietin; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mercury; Metals, Heavy; Nuclear Proteins; Protein Binding; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Zinc | 2000 |
Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain; Cobalt; DNA-Binding Proteins; Erythropoietin; Female; Fructose-Bisphosphate Aldolase; Gene Expression; Glucose Transporter Type 1; Glycolysis; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Ischemic Preconditioning; L-Lactate Dehydrogenase; Male; Monosaccharide Transport Proteins; Nuclear Proteins; Phosphofructokinase-1; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors | 2001 |
Cardiac function, microvascular structure, and capillary hematocrit in hearts of polycythemic rats.
Topics: Animals; Arterioles; Capillaries; Cobalt; Coronary Circulation; Erythropoietin; Hematocrit; Male; Microcirculation; Neovascularization, Pathologic; Polycythemia; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2001 |
Contribution of quinolinic acid in the development of anemia in renal insufficiency.
Topics: Anemia; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Survival; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Erythropoiesis; Erythropoietin; Humans; Kidney Failure, Chronic; Male; Neurotoxins; Organ Specificity; Quinolinic Acid; Rats; Rats, Wistar; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Studies on erythropoiesis. V. The effect of cobalt on the production of erythropoietin.
Topics: Cobalt; Epoetin Alfa; Erythrocytes; Erythropoiesis; Erythropoietin; Humans | 1958 |
Presence of an active erythropoietic factor (erythropoietin) in plasma of rats after prolonged cobalt therapy.
Topics: Animals; Cobalt; Epoetin Alfa; Erythrocytes; Erythropoietin; Health Services; Plasma; Rats | 1958 |
Effect of adrenalectomy on the erythropoietic response to sheep erythropoietin and cobalt.
Topics: Adrenalectomy; Animals; Cobalt; Epoetin Alfa; Erythropoietin; Hematopoietic System; Sheep; Sheep, Domestic | 1962 |
Relation between erythropoietin plasma level and oxygen requirements.
Topics: Anemia; Biological Assay; Cobalt; Epoetin Alfa; Erythropoietin; Humans; Hypophysectomy; Hypoxia; Oxygen; Starvation | 1963 |
The influence of cobalt and sheep erythropoietin on radioactive iron incorporation in RBC of starved intact and nephrectomized rats.
Topics: Animals; Cobalt; Epoetin Alfa; Erythrocytes; Erythropoietin; Iron; Nephrectomy; Rats; Sheep; Starvation | 1963 |
INFLUENCE OF COBALT, SHEEP ERYTHROPOIETIN AND SEVERAL HORMONES ON ERYTHROPOIESIS IN BONE MARROWS OF ISOLATED PERFUSED HIND LIMBS OF DOGS.
Topics: Animals; Bone Marrow; Chemotherapy, Cancer, Regional Perfusion; Cobalt; Dogs; Epoetin Alfa; Erythrocytes; Erythropoiesis; Erythropoietin; Femur; Growth Hormone; Human Growth Hormone; Hydrocortisone; Iron Isotopes; Research; Sheep; Testosterone; Triiodothyronine | 1964 |
INFLUENCE OF X-IRRADIATION OF THE DOG KIDNEY ON ERYTHROPOIETIN PRODUCTION.
Topics: Blood Chemical Analysis; Blood Pressure; Cobalt; Creatine; Creatinine; Dogs; Epoetin Alfa; Erythropoiesis; Erythropoietin; Iron Isotopes; Kidney; Kidney Function Tests; Nephrectomy; Nitrogen; Radiation Effects; Research; Urea | 1964 |
[STUDIES ON ERYTHROPOIETIN. INVESTIGATIONS ON ERYTHROPOIETIC ACTION OF SEVERAL HORMONES FROM THE POINT OF VIEW OF THEIR CALORIGENICITIES].
Topics: Adrenocorticotropic Hormone; Basal Metabolism; Cobalt; Cortisone; Epoetin Alfa; Erythropoietin; Hormones; Hypophysectomy; Pharmacology; Physiology; Pituitary Hormones, Anterior; Rats; Research; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine | 1964 |
THE EFFECT OF ANAEMIA AND COBALT ON LACTIC DEHYDROGENASE ISOENZYMES IN KIDNEY TISSUES OF RABBITS AND ITS POSSIBLE RELATION TO THE ERYTHROPOIETIN PRODUCTION.
Topics: Anemia; Animals; Blood Chemical Analysis; Cobalt; Electrophoresis; Enzymes; Epoetin Alfa; Erythropoietin; Iron Isotopes; Isoenzymes; Kidney; L-Lactate Dehydrogenase; Lagomorpha; Metabolism; Oxygen; Pharmacology; Rabbits; Research | 1965 |
Erythropoietin. I. Analysis of radioiron assay in fasted rats, using cobalt as a reference standard.
Topics: Animals; Biological Assay; Cobalt; Epoetin Alfa; Erythrocytes; Erythropoietin; Fasting; Protein Binding; Rats | 1960 |
Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha.
Topics: Air Pollutants, Occupational; Benzhydryl Compounds; Cell Hypoxia; Cell Line, Tumor; Cobalt; Erythropoietin; Estrogens, Non-Steroidal; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Phenols; Precipitin Tests; Structure-Activity Relationship; Transcription Factors | 2004 |
Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apigenin; Cell Line; Cobalt; Endothelial Cells; Endothelium, Vascular; Erythropoietin; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Transcription Factors; Vascular Endothelial Growth Factor A | 2004 |
Functional erythropoietin autocrine loop in melanoma.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Cobalt; Coloring Agents; Culture Media, Conditioned; Disease Progression; Dose-Response Relationship, Drug; Erythropoietin; Humans; Hypoxia; Immunohistochemistry; MAP Kinase Signaling System; Melanocytes; Melanoma; Membrane Potentials; Mitochondria; Phosphorylation; Receptors, Erythropoietin; Tetrazolium Salts; Thiazoles; Trypan Blue | 2005 |
Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis.
Topics: Animals; Antibodies; Antimutagenic Agents; Apoptosis; Capillaries; Cobalt; Erythropoietin; Gene Expression Regulation; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Isoantibodies; Kidney Tubules; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Reperfusion Injury; Vascular Endothelial Growth Factor A | 2005 |
Erythropoietin in thyroid cancer.
Topics: Carrier Proteins; Caseins; Cathepsin D; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Erythropoietin; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Proto-Oncogene Proteins; Receptors, Erythropoietin; RNA-Binding Proteins; RNA, Messenger; Thyroid Neoplasms; Tumor Suppressor Protein p53 | 2006 |
Cobalt supplementation promotes hypoxic tolerance and facilitates acclimatization to hypobaric hypoxia in rat brain.
Topics: Acclimatization; Adaptation, Physiological; Altitude Sickness; Animals; Cobalt; Erythropoietin; Glucose Transporter Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Species Specificity; Vascular Endothelial Growth Factor A | 2008 |
Heterogeneity in binding and gene-expression regulation by HIF-2alpha.
Topics: Anaerobiosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cobalt; Erythropoietin; Gene Expression; Gene Expression Regulation; Humans; Oxygen; Promoter Regions, Genetic; Transcriptional Activation | 2008 |
Hypoxic preconditioning facilitates acclimatization to hypobaric hypoxia in rat heart.
Topics: Acclimatization; Animals; Cardiotonic Agents; Cobalt; DNA-Binding Proteins; Erythropoietin; Heart; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Metallothionein; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Recovery of motor spontaneous activity after intranasal delivery of human recombinant erythropoietin in a focal brain hypoxia model induced by CoCl2 in rats.
Topics: Administration, Intranasal; Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cobalt; Disease Models, Animal; Erythropoietin; Exploratory Behavior; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Erythropoietin; Recombinant Proteins; Recovery of Function; Reticulocytes; Rotarod Performance Test | 2011 |
Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner.
Topics: Animals; Blotting, Western; Cobalt; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Gene Expression Regulation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1; Indican; Indoles; Kidney Failure, Chronic; Luciferases; Oxygen; Rats; Uremia | 2011 |
Bone marrow-derived mesenchymal stem cells prevent the apoptosis of neuron-like PC12 cells via erythropoietin expression.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspases; Cell Hypoxia; Cells, Cultured; Cobalt; Cytoprotection; Erythropoietin; Gene Knockdown Techniques; Male; Mesenchymal Stem Cells; Neurons; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Up-Regulation | 2012 |
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.
Topics: 3' Untranslated Regions; Activating Transcription Factor 4; Animals; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cell Hypoxia; Cell Nucleus; Cobalt; Endoplasmic Reticulum Stress; Enhancer Elements, Genetic; Erythropoietin; Hep G2 Cells; Humans; Kidney; Liver; Male; Protein Binding; Protein Transport; Rats; Rats, Wistar; Transcription, Genetic; Transcriptional Activation; Unfolded Protein Response | 2013 |
Protective action of erythropoietin on neuronal damage induced by activated microglia.
Topics: Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cobalt; Culture Media, Conditioned; Erythropoietin; Humans; Inflammation; Mice; Microglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase Type II; Nitrites; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Receptors, Erythropoietin; Tumor Necrosis Factor-alpha | 2013 |
The role of HIF in cobalt-induced ischemic tolerance.
Topics: Amino Acids, Dicarboxylic; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Cobalt; Deferoxamine; Erythropoietin; Hippocampus; Hypoxia-Inducible Factor 1; Immunohistochemistry; Ischemic Preconditioning; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Prolyl-Hydroxylase Inhibitors | 2013 |
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Topics: Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cobalt; Deferoxamine; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphoglycerate Kinase; Promoter Regions, Genetic; Propanolamines; Protein Binding; Pyrrolidines; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Upstream Stimulatory Factors | 2013 |
SOME PROPERTIES OF SERUM FROM RABBITS IMMUNIZED WITH HUMAN URINARY ERYTHROPOIETIN. UCRL-11184.
Topics: Adrenocorticotropic Hormone; Animals; Antigen-Antibody Reactions; Ceruloplasmin; Cobalt; Epoetin Alfa; Erythropoiesis; Erythropoietin; Freund's Adjuvant; gamma-Globulins; Hematocrit; Hydrocortisone; Immune Sera; Immunization; Iron; Iron Isotopes; Mice; Mucoproteins; Neuraminic Acids; Neutralization Tests; Phenylhydrazines; Polycythemia; Rabbits; Research; Thyroxine; Transferrin; Urine | 1963 |
The effects of CoCl2 on HIF-1α protein under experimental conditions of autoprogressive hypoxia using mouse models.
Topics: Animals; Cobalt; DNA; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Models, Animal; Protein Binding; RNA, Messenger; Vascular Endothelial Growth Factor A | 2014 |
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chromones; Cobalt; Disease Models, Animal; Erythropoietin; Humans; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Morpholines; Peptide Fragments; Proto-Oncogene Proteins c-akt; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Analysis of cobalt for human sports drug testing purposes using ICP- and LC-ICP-MS.
Topics: Adult; Chromatography, Liquid; Cobalt; Doping in Sports; Erythropoietin; Female; Humans; Male; Mass Spectrometry; Middle Aged; Substance Abuse Detection; Tandem Mass Spectrometry; Vitamin B 12; Young Adult | 2020 |