cobalt has been researched along with heme in 181 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 121 (66.85) | 18.7374 |
| 1990's | 22 (12.15) | 18.2507 |
| 2000's | 15 (8.29) | 29.6817 |
| 2010's | 19 (10.50) | 24.3611 |
| 2020's | 4 (2.21) | 2.80 |
| Authors | Studies |
|---|---|
| Flatmark, T; Koller, ME; Romslo, I | 1 |
| Hino, Y; Minakami, S | 1 |
| Buchler, JW | 1 |
| Kikuchi, G; Yoshida, T | 2 |
| Hendry, GA; Jones, OT; Lodola, A | 1 |
| DiNello, RK; Dolphin, DH | 1 |
| Woods, JS | 2 |
| Nagai, K; Tsubaki, M | 1 |
| gardner, FH; Gorshein, D; Reisner, EH | 1 |
| Kappas, A; Maines, MD | 8 |
| Piper, W; Sedman, R; Tephly, TR; Wagner, G | 1 |
| Asagami, H; Hino, Y; Minakami, S | 1 |
| de Matteis, F; Gibbs, AH; Sinclair, JF; Sinclair, P | 1 |
| Maines, MD; Sinclair, P | 1 |
| Kikuchi, G; Shibahara, S; Yoshida, T | 1 |
| Marks, V; Taylor, A | 1 |
| Perutz, MF | 1 |
| De Matteis, F; Unseld, A | 1 |
| Fuhr, JE; Leisy, M; Overton, M | 1 |
| Janousĕk, V; Kappas, A; Maines, MD; Tomio, JM | 1 |
| Maines, MD | 2 |
| De Matteis, F; Gibbs, AH | 2 |
| Cohn, J; Maines, MD | 1 |
| Minakami, S; Nakamura, M; Yasukochi, Y | 3 |
| Bissell, DM; Guzelian, PS | 1 |
| Cunningham, VJ; De Matteis, F; Stonard, MD | 1 |
| Nakamura, M | 1 |
| Correia, MA; Schmid, R | 1 |
| Correia, MA; Meyer, UA | 1 |
| Tephly, TR; Wagner, GS | 1 |
| Cornelius, CE; Freedland, RA; Rodgers, PA | 1 |
| Hori, H; Ikeda-Saito, M; Lutz, RS; Mattera, R; McKelvey, EJ; Shelley, DA | 1 |
| Gold, MH; Harris, RZ; Ortiz de Montellano, PR; Wariishi, H | 1 |
| Dutta, GP; Pandey, VC; Sahni, SK; Saxena, N; Tekwani, BL | 1 |
| Abraham, NG; Lin, JH; Martasek, P; Villalon, P | 1 |
| Alam, J; Shibahara, S; Smith, A | 1 |
| Fujino, S; Hoshi, K; Senda, N | 1 |
| Dolphin, D | 1 |
| Maines, MD; Veltman, JC | 1 |
| Chhabra, R; Datta, K; Singh, NK | 1 |
| Maines, MD; Rowley, PT; Trakshel, GM | 1 |
| Jayarama Bhat, G; Padmanaban, G | 1 |
| Bhat, GJ; Padmanaban, G | 1 |
| Drummond, GS; Kappas, A | 2 |
| Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G | 1 |
| Hronis, TS; Traugh, JA | 1 |
| Gersonde, K; Overkamp, M; Parish, DW; Sick, H; Smith, KM | 1 |
| Drummond, GS; Sardana, MK | 1 |
| Belovetskaia, IV; Kaliman, PA | 1 |
| Klaassen, CD; Stelzer, KJ | 1 |
| Kadiiska, M; Serbinova, E; Stoytchev, T | 1 |
| Drummond, GS; Kappas, A; Sardana, MK | 1 |
| Padmanaban, G; Ravishankar, H | 2 |
| Morgan, WT; Muller-Eberhard, U | 1 |
| Muller-Eberhard, U; Seery, VL | 1 |
| Melcer, I; Orten, JM; Sardesai, VM | 1 |
| Jones, MS; Jones, OT | 1 |
| Jänig, GR; Jung, F; Rein, H; Ristau, O; Ruckpaul, K | 1 |
| Chien, CW; Dickinson, LC | 1 |
| Borg, DC; Dolphin, D; Fajer, J; Felton, RH; Forman, A; Owen, GS | 1 |
| Martinez-Medellin, J; Schulman, HM; Sidloi, R | 1 |
| Arcand, C; Caldwell, DR | 1 |
| Hoffman, BM; Petering, DH; Spilburg, CA | 1 |
| Fuhrhop, JH; Wasser, PK | 1 |
| Barnes, R; Jones, OT | 1 |
| Hoard, JL; Scheidt, WR | 1 |
| Schacter, BA; Waterman, MR | 1 |
| Goldwasser, E | 1 |
| Burka, ER | 1 |
| Ibers, JA; Stynes, HC | 1 |
| Hirano, Y; Olcott, HS | 1 |
| McKellar, JR; Weightman, JA; Williams, RJ | 1 |
| Mazur, A | 1 |
| Waxman, HS | 1 |
| Hasegawa, E; Smith, C; Tephly, TR | 1 |
| Smith, RP | 1 |
| Bessman, SP; Hammel-Dupont, CL | 1 |
| Chaix, P; Labbe, P; Volland, C | 1 |
| Jobe, A; Schulman, HM | 1 |
| O'Brien, PJ | 1 |
| Muthukrishnan, S; Padmanaban, G; Sarma, PS | 1 |
| Padmanaban, G; Sarma, PS | 1 |
| Benzi, G; Corona, GL | 1 |
| Maxia, V; Miloni, S; Rollier, MA; Valentini, MT | 1 |
| Kitchin, KT | 1 |
| Chien, JC; Dickinson, LC | 1 |
| Hori, H; Ikeda-Saito, M; Yonetani, T | 1 |
| Antonini, E; Ascoli, F; Chiancone, E; Ikeda-Saito, M; Santucci, R; Verzili, D; Yonetani, T | 1 |
| Höhn, M; Hüttermann, J | 1 |
| Kutty, RK; Maines, MD | 1 |
| Hayashi, N; Kikuchi, G | 1 |
| Hooper, AB; Hyzy, B; Lageson, J; Ruben, L | 1 |
| Mackin, HC; Tsubaki, M; Yu, NT | 1 |
| Kaliman, PA; Padalko, VI | 1 |
| Ibrahim, NG; Levere, RD; Nelson, JC | 1 |
| Drummond, GS; Kappas, A; Kourides, IA; Smith, TJ | 1 |
| Chien, JC; Dickinson, LC; Fermi, G; Perutz, MF | 1 |
| Bonkowsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR; Smith, EL | 1 |
| Lodola, A | 1 |
| Ponka, P; Schulman, HM | 1 |
| Browlett, WR; Stillman, MJ | 1 |
| Immenschuh, S; Iwahara, S; Katz, N; Muller-Eberhard, U; Nell, C; Satoh, H | 1 |
| Awruch, J; Coll, CT; Frydman, RB; Lemberg, A; Mora, ME | 1 |
| Correia, MA; Liu, H | 1 |
| Goldberg, MA; Schneider, TJ | 1 |
| Abraham, NG; Griffin, MO; Kappas, A; Levere, RD; Lutton, JD; Nishimura, M; Shibahara, S | 1 |
| Dou, Y; Gibson, QH; Ikeda-Saito, M; Li, T; Olson, JS; Regan, R; Yonetani, T | 1 |
| Sarti, P; Silvestrini, MC; Tegoni, M | 1 |
| Bonkovsky, HL; Gabis, KK; Gildemeister, OS; Lambrecht, RW; Pepe, JA | 1 |
| Fazzio, TG; Roth, JR | 1 |
| Nirodi, CS; Padmanaban, G; Prabhu, L; Ram, N; Sultana, S | 1 |
| Heathcote, P; Rambach, A; Raux, E; Thermes, C; Warren, MJ | 1 |
| Bonkovsky, HL; Gildemeister, OS; Lu, TH; Pepe, JA; Tyrrell, RM | 1 |
| Hori, H; Iizuka, T; Makino, R; Matsuda, H; Obayashi, E; Shiro, Y | 1 |
| Kirchgessner, M; Schwarz, FJ; Stangl, GI | 1 |
| Dou, Y; Gooding, EA; Hochstrasser, RM; Ikeda-Saito, M; Kholodenko, Y | 1 |
| Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T | 1 |
| Avadhani, NG; Damle, S; Lenka, N; Vijayasarathy, C | 1 |
| Coutinho, C; O'Brodovich, H; Otulakowski, G; Rafii, B | 1 |
| Abraham, NG; Drummond, GS; Jiang, S; Kappas, A; Laniado-Schwartzman, M; Marji, J; Yang, L; Zand, BA | 1 |
| Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T; Ziemann, C | 1 |
| Fujita, H; Furuyama, K; Hattori, T; Hida, W; Igarashi, K; Kitamuro, T; Nakayama, M; Ogawa, K; Shibahara, S; Shirato, K; Sun, J; Takahashi, K; Takeda, K; Udono-Fujimori, R | 1 |
| LAFORET, MT; THOMAS, ED | 1 |
| GEORGE, P; GLAUSER, SC; IRVINE, DH | 1 |
| ABRAROV, AA | 1 |
| BEHLKE, J; SCHELER, W; THIELE, HJ | 1 |
| OZOLS, J; STRITTMATTER, P | 1 |
| LENDLE, L | 1 |
| JOHNSON, A; JONES, OG | 1 |
| LABEYRIE, F; SLONIMSKI, PP | 1 |
| PORRA, RJ; ROSS, BD | 1 |
| Chao, MP; Pendrak, ML; Roberts, DD; Yan, SS | 1 |
| Harvey, JD; Ziegler, CJ | 1 |
| Degtyarenko, I; Nieminen, RM; Rovira, C | 1 |
| Raghothama, S; Rai, J; Sahal, D | 1 |
| Ahmad, M; Chow, JL; Gupte, SA; Mingone, CJ; Wolin, MS | 1 |
| Brindley, AA; Hill, CP; Leech, HK; Rigby, SE; Rose, RS; Schubert, HL; Warren, MJ | 1 |
| Kincaid, JR; Mak, PJ | 1 |
| Kraus, JP; Kruger, WD; Majtan, T; Singh, LR; Wang, L | 1 |
| Furuyama, K; Sassa, S; Shibahara, S; Vargas, PD | 1 |
| Chan, P; Chang, CF; Chen, CH; Chen, TH; Lee, HM; Wang, JC; Yu, SC | 1 |
| Carter, M; Dailey, HA; Dailey, TA; Lanzilotta, WN; Medlock, AE | 1 |
| Sedman, RM; Tephly, TR | 1 |
| Brugna, M; Hederstedt, L; Tasse, L | 1 |
| Burstyn, JN; Freeman, KM; Kraus, JP; Majtan, T; Smith, AT; Su, Y | 1 |
| Bielecki, M; Olczak, M; Olczak, T; Smalley, JW; Wojaczyński, J; Wójtowicz, H | 1 |
| Hoshino, T; Kawaguchi, AT; Neya, S; Suzuki, M | 1 |
| Ibrahim, M; Soldatova, AV; Spiro, TG | 1 |
| Kawaguchi, AT; Neya, S; Yonetani, T | 1 |
| Deng, S; Ji, X; Shan, D; Yuan, P; Zhang, X | 1 |
| Liu, H; Liu, Q; Zhang, X; Zhou, X; Zhou, Z | 1 |
| Nowak, W; Rydzewski, J | 1 |
| Holtmann, D; Roccatano, D; Schwaneberg, U; Verma, R | 1 |
| Doitomi, K; Hayashi, T; Hisaeda, Y; Kamachi, T; Morita, Y; Ohbayashi, J; Oohora, K; Sawada, A; Yoshizawa, K | 1 |
| Hayashi, T; Inoue, T; Kamachi, T; Mizohata, E; Morita, Y; Oohora, K; Sawada, A; Yoshizawa, K | 1 |
| Bronshtein, MD; Hansen, NS; Nazmutdinov, RR; Ulstrup, J; Zhang, J; Zinkicheva, TT | 1 |
| Hayashi, T; Morita, Y; Oohora, K; Tang, N | 1 |
| Bocola, M; Davari, MD; Mueller-Dieckmann, J; Panneerselvam, S; Schwaneberg, U; Shehzad, A; Wilmanns, M | 1 |
| Bhagi-Damodaran, A; Chakraborty, S; Lu, Y; Mirts, EN; Moënne-Loccoz, P; Petrik, ID; Reed, JH; Ross, M; Shi, Y; Zhang, Y; Zhu, Q | 1 |
| Glade, MJ; Meguid, MM | 1 |
| Li, J; Ma, F; Peng, Q; Sun, CJ; Sun, HL; Wang, Z; Wu, Q; Xiao, H; Xu, W; Zhao, J | 1 |
| Abucayon, EG; Khade, RL; Powell, DR; Richter-Addo, GB; Zhang, Y | 1 |
| Buller, AR; Burstyn, JN; Perkins, LJ; Weaver, BR | 1 |
| Fakih, TM; Kurniawan, F; Mudasir, M; Tjahjono, DH; Yusuf, M | 1 |
| Chakraborty, P; Garribba, E; Rath, SP; Sanfui, S | 1 |
| Abreu, I; González-Guerrero, M; Mihelj, P; Moreyra, T; Raimunda, D | 1 |
12 review(s) available for cobalt and heme
| Article | Year |
|---|---|
Hemoglobin--an inspiration for research in coordination chemistry.
Topics: Chemical Phenomena; Chemistry; Cobalt; Globins; Heme; Hemin; Hemoglobins; Humans; Models, Chemical; Myoglobin; Osmium; Oxyhemoglobins; Porphyrins; Ruthenium | 1978 |
Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Heme; Humans; In Vitro Techniques; Iron; Kidney; Microsomes; Microsomes, Liver; Myocardium; Nickel; Pharmaceutical Preparations | 1977 |
Effects of metals on heme biosynthesis and metabolism.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Copper; Cytochrome P-450 Enzyme System; Ferrochelatase; Heme; Hydroxymethylbilane Synthase; Liver; Male; Manganese Poisoning; Metals; Microsomes; Rats | 1978 |
[Mechanism of heme catabolism (author's transl)].
Topics: Ascorbic Acid; Biliverdine; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Oxidation-Reduction; Protoporphyrins; Stereoisomerism | 1979 |
Structure and mechanism of haemoglobin.
Topics: Allosteric Regulation; Animals; Chemical Phenomena; Chemistry; Cobalt; Heme; Hemoglobins; Hemoglobins, Abnormal; Histidine; Horses; Humans; Iron; Lampreys; Ligands; Methemoglobin; Models, Structural; Myoglobin; Oxygen; Protein Conformation; Structure-Activity Relationship; Whales | 1976 |
Increased liver haem degradation caused by foreign chemicals: a comparison of the effects of 2-allyl-2-isopropylacetamide and cobaltous chloride.
Topics: Acetamides; Allylisopropylacetamide; Animals; Bile Ducts; Bilirubin; Cobalt; Heme; Liver; Male; Mixed Function Oxygenases; Pigments, Biological; Rats; Time Factors | 1976 |
Control of heme metabolism with synthetic metalloporphyrins.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythrocytes; Heme; Heme Oxygenase (Decyclizing); Humans; Kidney; Liver; Metalloporphyrins; Protoporphyrins; Tin | 1986 |
Biochemical control of erythroid cell development.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Differentiation; Cobalt; Dactinomycin; Erythropoiesis; Erythropoietin; Genes, Regulator; Glucosamine; Glycols; Hematopoietic Stem Cells; Heme; Hemoglobins; In Vitro Techniques; Models, Biological; Pituitary Gland; Rats; Reticulocytes; RNA; Steroids; Thyroid Hormones | 1966 |
Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cell-Free System; Cobalt; Cytosol; Dicarbethoxydihydrocollidine; Heme; Hemin; Immunodiffusion; Leucine; Liver; Mitochondria, Liver; Molecular Weight; Protoporphyrins; Rabbits; Rats; Tryptophan Oxygenase | 1981 |
[MODE OF ACTION OF LACTATE DEHYDROGENASES LINKED TO FLAVIN AND CYTOCHROME SYSTEMS].
Topics: Biochemical Phenomena; Biochemistry; Cobalt; Cytochromes; Edetic Acid; Electron Transport; Enzyme Inhibitors; Ferrocyanides; Flavin Mononucleotide; Flavins; Heme; Ions; L-Lactate Dehydrogenase; Lactate Dehydrogenases; Lactates; Manganese; Mitochondria; Mutation; Oxalates; Phosphates; Research; Spectrum Analysis; Yeasts; Zinc | 1964 |
The metal complexes of N-confused porphyrin as heme model compounds.
Topics: Cobalt; Heme; Iron; Ligands; Manganese; Metalloporphyrins; Models, Molecular | 2006 |
Not Limited to Iron: A Cobalt Heme-NO Model Facilitates N-N Coupling with External NO in the Presence of a Lewis Acid to Generate N
Topics: Cobalt; Heme; Humans; Iron; Lewis Acids; Molecular Structure; Nitric Oxide; X-Ray Diffraction | 2019 |
169 other study(ies) available for cobalt and heme
| Article | Year |
|---|---|
Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration.
Topics: Animals; Ascorbic Acid; Cobalt; Ferrochelatase; Heme; Hydrogen-Ion Concentration; Kinetics; Liposomes; Lyases; Mitochondria, Liver; Oxygen Consumption; Porphyrins; Rats; Spectrophotometry | 1976 |
Electron-transport pathway of the NADH-dependent haem oxygenase system of rat liver microsomal fraction induced by cobalt chloride.
Topics: Animals; Biliverdine; Cobalt; Electron Transport; Enzyme Induction; Heme; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Rats | 1979 |
Reaction of the microsomal heme oxygenase with cobaltic protoporphyrin IX, and extremely poor substrate.
Topics: Animals; Cobalt; Female; Heme; Kidney; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Porphyrins; Protein Binding; Protoporphyrins; Rats; Spectrophotometry; Spleen; Swine | 1978 |
Haem oxygenase: a reappraisal of the stoicheiometry.
Topics: Animals; Cobalt; Enzyme Induction; Heme; Kinetics; Liver; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Rats; Spectrophotometry | 1979 |
Analytical chromatography of hemins on silica gel.
Topics: Chromatography, Thin Layer; Cobalt; Heme; Hemin; Iron; Manganese; Methods; Microchemistry; Silicon Dioxide | 1975 |
Heme regulation of cytochrome oxidase synthesis in fetal rat liver.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cobalt; Cycloheximide; Electron Transport Complex IV; Female; Fetus; Heme; In Vitro Techniques; Leucine; Mitochondria, Liver; Pregnancy; Rats; Time Factors | 1977 |
Effect of removal of a salt-bridge on the oxygen binding properties and the electronic structure of heme in cobalt-iron hybrid hemoglobin.
Topics: Binding Sites; Cobalt; Electron Spin Resonance Spectroscopy; Heme; Hemoglobin A; Humans; Iron; Kinetics; Oxyhemoglobins; Protein Binding | 1979 |
Tissue culture of bone marrow. V. Effect of 5Beta(H) steroids and cyclic AMP on heme synthesis.
Topics: Androstanes; Bone Marrow; Bucladesine; Calcium; Cobalt; Culture Techniques; Cyclic AMP; Cyproterone; Drug Synergism; Erythropoiesis; Erythropoietin; Heme; Humans; Hydroxysteroids; Immune Sera; Ketosteroids; Pregnanediones; Pregnanes; Pregnanolone; Stimulation, Chemical; Theophylline | 1975 |
Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols.
Topics: 5-Aminolevulinate Synthetase; Animals; Binding Sites; Cobalt; Cysteine; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutathione; Heme; Kidney; Liver; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Nickel; Platinum; Rats; Trace Elements | 1977 |
Topological arrangement in microsomal membranes of hepatic haem oxygenase induced by cobalt chloride.
Topics: Animals; Biliverdine; Centrifugation, Isopycnic; Cobalt; Enzyme Induction; Heme; In Vitro Techniques; Intracellular Membranes; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Trypsin | 1979 |
Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cobalt; Electrophoresis, Polyacrylamide Gel; Heme; Liver; Male; Metals; Porphyrins; Protoporphyrins; Rats; Spectrophotometry | 1979 |
Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture.
Topics: Animals; Cations, Divalent; Cells, Cultured; Chick Embryo; Cobalt; Cycloheximide; Dactinomycin; Enzyme Induction; Heme; Iron; Liver; Maleates; Mixed Function Oxygenases | 1977 |
Induction of heme oxygenase by hemin in cultured pig alveolar macrophages.
Topics: Animals; Cells, Cultured; Cobalt; Enzyme Induction; Heme; Hemin; Hormones; Kinetics; Macrophages; Mixed Function Oxygenases; Protoporphyrins; Pulmonary Alveoli; RNA, Messenger; Swine | 1978 |
Cobalt:a review.
Topics: Alloys; Anemia; Animals; Beer; Cobalt; Enzyme Inhibitors; Food Contamination; Heart Diseases; Heme; Humans; Hyperlipidemias; Iron; Joint Prosthesis; Lipids; Neoplasms; Tissue Distribution; Vitamin B 12 | 1978 |
Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period.
Topics: Animals; Animals, Newborn; Bilirubin; Cell Fractionation; Cobalt; Cytochrome P-450 Enzyme System; Embryo, Nonmammalian; Ethylmorphine-N-Demethylase; Fetus; Heme; Injections, Subcutaneous; Liver; Microsomes, Liver; Milk; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Rats; Spectrophotometry | 1975 |
The effect of cobalt on haemoglobin synthesis in primate reticulocytes.
Topics: Aminolevulinic Acid; Animals; Callitrichinae; Cobalt; Dose-Response Relationship, Drug; Globins; Haplorhini; Heme; Hemoglobins; Iron; Isoniazid; Reticulocytes | 1975 |
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Enzyme Induction; Heme; Hydroxymethylbilane Synthase; Liver; Lyases; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Porphyrins; Rats | 1976 |
Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cations, Divalent; Cobalt; Cysteine; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Glutathione; Heme; Liver; Male; Maleates; Metals; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygenases; Rats; Vitamin E | 1976 |
Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ethylmorphine-N-Demethylase; Heme; Hydro-Lyases; Kidney; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Polychlorinated Biphenyls; Porphobilinogen Synthase; Porphyrins; Rats | 1976 |
Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action.
Topics: Animals; Bone Marrow; Cobalt; Heme; Kidney; Kinetics; Macrophages; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Nickel; Oxidation-Reduction; Porphyrins; Protoporphyrins; Rats | 1977 |
Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Cobalt; Heme; Liver | 1977 |
Bile pigment formation by skin heme oxygenase: studies on the response of the enzyme to heme compounds and tissue injury.
Topics: Animals; Bilirubin; Cobalt; Contusions; Heme; Liver; Microsomes; Mixed Function Oxygenases; Protoporphyrins; Rats; Skin; Wounds and Injuries | 1977 |
Effect of cobalt on the synthesis of liver microsomal cytochromes.
Topics: Aminolevulinic Acid; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Leucine; Male; Microsomes, Liver; Protein Biosynthesis; Rats; Trypsin | 1977 |
Effect of cobalt on synthesis of heme and cytochrome P-450 in the liver. Studies of adult rat hepatocytes in primary monolayer culture and in vivo.
Topics: Aminolevulinic Acid; Aniline Hydroxylase; Animals; Carbon Monoxide; Cells, Cultured; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Liver; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry | 1976 |
The effect of cobalt on the uptake of plasma iron by the liver.
Topics: Animals; Cobalt; Heme; Iron; Liver; Male; Rats; Serum Albumin, Radio-Iodinated | 1976 |
Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity.
Topics: 5-Aminolevulinate Synthetase; Aging; Amitrole; Animals; Animals, Newborn; Cobalt; Female; Fetus; Heme; Hydroxymethylbilane Synthase; Liver; Male; Porphobilinogen Synthase; Pregnancy; Rats | 1976 |
[Effect of cobalt on various hemoproteins in rat liver and spleen (author's transl)].
Topics: Acetyltransferases; Animals; Catalase; Cobalt; Cytochrome P-450 Enzyme System; Heme; Hydro-Lyases; Liver; Lyases; Male; Rats; Spleen | 1976 |
The effect of cobaltous chloride on liver haem metabolism in the rat. Evidence for inhibition of haem synthesis and for increased haem degradation.
Topics: 5-Aminolevulinate Synthetase; Animals; Bile Pigments; Bilirubin; Chlorides; Cobalt; Ferrochelatase; Heme; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Porphyrins; Rats | 1976 |
The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase.
Topics: Aminolevulinic Acid; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Kidney; Male; Metals; Microsomes, Liver; Mitochondria, Liver; Myocardium; Oxygenases; Rats | 1976 |
Effect of cobalt on microsomal cytochrome P-450: differences between liver and intestinal mucosa.
Topics: Animals; Benzopyrene Hydroxylase; Cobalt; Cytochrome P-450 Enzyme System; Heme; Intestinal Mucosa; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Rats | 1975 |
Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro.
Topics: Animals; Apoproteins; Binding Sites; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Enzyme Inhibitors; Enzyme Precursors; Heme; Hemin; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats | 1975 |
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Bilirubin; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dactinomycin; Ethylmorphine-N-Demethylase; Heme; Iodides; Liver; Microsomes, Liver; Oxygen Consumption; Porphyrins; Puromycin; Rats; Thiocyanates; Time Factors; Triazoles; Urea | 1975 |
A possible role of copper in the regulation of heme biosynthesis through ferrochelatase.
Topics: Animals; Cations, Divalent; Cobalt; Copper; Cytochrome P-450 Enzyme System; Heme; Iron; Iron Radioisotopes; Kinetics; Lead; Liver; Lyases; Male; Manganese; Mitochondria, Liver; Porphyrins; Rats | 1975 |
Effect of cobalt on heme biosynthesis in rat liver and spleen.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Heme; Kinetics; Liver; Lyases; Male; Mitochondria; Mitochondria, Liver; Porphobilinogen Synthase; Rats; Spleen; Subcellular Fractions; Time Factors | 1975 |
Bilirubin production and conjugation from newly formed heme in isolated rat hepatocytes.
Topics: Aminolevulinic Acid; Animals; Bile Pigments; Bilirubin; Cells, Cultured; Cobalt; Heme; Hemin; Kinetics; Liver; Male; Metalloporphyrins; Protoporphyrins; Rats; Rats, Sprague-Dawley | 1992 |
EPR characterization of the stereochemistry of the distal heme pocket of the engineered human myoglobin mutants.
Topics: Binding Sites; Cloning, Molecular; Cobalt; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Humans; Mutagenesis, Site-Directed; Myoglobin; Protein Conformation; Protein Engineering; Recombinant Proteins | 1991 |
The catalytic site of manganese peroxidase. Regiospecific addition of sodium azide and alkylhydrazines to the heme group.
Topics: Azides; Basidiomycota; Binding Sites; Cations, Divalent; Cobalt; Electron Spin Resonance Spectroscopy; Heme; Hydrogen-Ion Concentration; Manganese; Peroxidases; Sodium Azide | 1991 |
Status of hepatic heme and heme oxygenase during Plasmodium yoelii nigeriensis infection in mice.
Topics: Administration, Oral; Animals; Cell Fractionation; Chloroquine; Cobalt; Heme; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Liver; Malaria; Mice; Plasmodium yoelii | 1991 |
Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney.
Topics: Animals; Arginine; Cobalt; DNA; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Nucleic Acid Hybridization; Plasmids; Protoporphyrins; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1990 |
Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells.
Topics: Animals; Cadmium; Cell Nucleus; Cobalt; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Hot Temperature; Liver Neoplasms, Experimental; Mice; Mixed Function Oxygenases; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Acute effect of amitriptyline, phenobarbital or cobaltous chloride on delta-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver.
Topics: 5-Aminolevulinate Synthetase; Amitriptyline; Animals; Cobalt; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Cytochrome P450: substrate and prosthetic-group free radicals generated during the enzymatic cycle.
Topics: Catalase; Catalysis; Cobalt; Cyclohexanes; Cytochrome P-450 Enzyme System; Epoxy Compounds; Free Radicals; Heme; Horseradish Peroxidase; Hydroxylation; Iron; Magnesium; Oxidation-Reduction; Oxygen; Porphyrins; Spectrum Analysis | 1985 |
Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal.
Topics: 5-Aminolevulinate Synthetase; Adrenal Glands; Animals; Cadmium; Cobalt; Corticosterone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dehydroepiandrosterone; Ferrochelatase; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Mercury; Microsomes; Mitochondria; NADPH-Ferrihemoprotein Reductase; Porphyrins; Progesterone; Rats; Steroid 21-Hydroxylase | 1986 |
Induction of L-alanine:4,5-dioxovalerate transaminase by phenylhydrazine is associated with depletion of heme level.
Topics: Anemia; Animals; Cobalt; Dactinomycin; Erythropoietin; Hematocrit; Heme; Immune Sera; Immunodiffusion; Kidney; Kinetics; Liver; Male; Phenylhydrazines; Rats; Rats, Inbred Strains; Transaminases | 1986 |
Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine.
Topics: Bromobenzenes; Cell Line; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Erythroblastic, Acute; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidine | 1987 |
Heme regulates cytochrome P-450 gene transcription elongation.
Topics: Animals; Cell Nucleus; Cobalt; Cytochrome P-450 Enzyme System; Genes; Heme; Kinetics; Methylcholanthrene; Rats; RNA, Messenger; Transcription, Genetic | 1988 |
Heme is a positive regulator of cytochrome P-450 gene transcription.
Topics: Amitrole; Animals; Base Sequence; Cobalt; Cytochrome P-450 Enzyme System; DNA; DNA, Recombinant; Heme; Male; Methylcholanthrene; Molecular Sequence Data; Nucleic Acid Hybridization; Rats; RNA, Messenger; Thioacetamide; Transcription, Genetic | 1988 |
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme.
Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger | 1987 |
Structural requirements for porphyrin inhibition of the hemin-controlled protein kinase and maintenance of protein synthesis in reticulocytes.
Topics: Animals; Cobalt; Coproporphyrins; Eukaryotic Initiation Factor-2; Heme; Hemin; Magnesium; Peptide Initiation Factors; Phosphorylation; Porphyrins; Protein Biosynthesis; Protein Kinase Inhibitors; Proteins; Protoporphyrins; Rabbits; Reticulocytes; Zinc | 1986 |
Bohr effect in monomeric insect haemoglobins controlled by O2 off-rate and modulated by haem-rotational disorder.
Topics: Chironomidae; Cobalt; Heme; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mathematics; Optical Rotation; Oxyhemoglobins; Porphyrins; Protein Conformation | 1986 |
Tryptophan pyrrolase in heme metabolism. Comparative actions of inorganic tin and cobalt and their protoporphyrin chelates on tryptophan pyrrolase in liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kinetics; Liver; Male; Porphyrins; Protoporphyrins; Rats; Tin; Tryptophan Oxygenase | 1986 |
[Effect of cobalt chloride on the activity of key enzymes of heme metabolism in the rat liver].
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Cycloheximide; Dactinomycin; Enzyme Activation; Heme; Heme Oxygenase (Decyclizing); Kinetics; Liver; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1986 |
Effect of cobalt on biliary excretion of bilirubin and glutathione.
Topics: Animals; Bile; Bilirubin; Chromatography, High Pressure Liquid; Cobalt; Glutathione; Heme; Heme Oxygenase (Decyclizing); Injections, Subcutaneous; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains | 1985 |
On the mechanism of the enzyme-inducing action of some heavy metal salts.
Topics: 5-Aminolevulinate Synthetase; Animals; Cadmium; Cobalt; Cytochrome b Group; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Glucuronosyltransferase; Heme; Male; Mercury; Metals; Microsomes, Liver; Nickel; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains; Zinc | 1985 |
Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.
Topics: Animals; Cobalt; Dose-Response Relationship, Drug; Heme; Kinetics; Liver; Male; Metalloporphyrins; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1985 |
Turnover of messenger RNA, apoprotein and haem of cytochrome P-450b + e induced by phenobarbitone in rat liver.
Topics: 5-Aminolevulinate Synthetase; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Heme; Liver; Male; Phenobarbital; Rats; RNA, Messenger | 1985 |
Interactions of porphyrins with rabbit hemopexin.
Topics: Animals; Apoproteins; Beta-Globulins; Blood Protein Electrophoresis; Chemical Phenomena; Chemistry; Circular Dichroism; Cobalt; Deuterium; Heme; Hemeproteins; Hemopexin; Hydrogen-Ion Concentration; Kinetics; Nickel; Porphyrins; Protein Binding; Protein Conformation; Rabbits; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfites | 1972 |
Binding of porphyrins to rabbit hemopexin and albumin.
Topics: Animals; Apoproteins; Beta-Globulins; Binding, Competitive; Cobalt; Deuterium; Dialysis; Heme; Hemopexin; Iron; Metalloproteins; Nickel; Porphyrins; Protein Binding; Protein Precursors; Rabbits; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship | 1973 |
The effects of certain inorganic ions on in vitro porphyrin--heme formation.
Topics: Animals; Arsenic; Cattle; Chickens; Cobalt; Copper; Depression, Chemical; Dose-Response Relationship, Drug; Edetic Acid; Erythrocytes; Heme; In Vitro Techniques; Iron; Levulinic Acids; Liver; Molybdenum; Porphyrins; Stimulation, Chemical; Uranium; Zinc | 1973 |
The structural organization of haem synthesis in rat liver mitochondria.
Topics: Adenosine Triphosphate; Animals; Cobalt; Electron Transport Complex IV; Heme; In Vitro Techniques; Iron; Lyases; Membranes; Mitochondria, Liver; Porphyrins; Rats; Spectrophotometry; Sucrose | 1969 |
Interaction of hemoglobin with ions. Allosteric effects of the binding of anions.
Topics: Adenosine Triphosphate; Adult; Chemical Phenomena; Chemistry; Cobalt; Cyanides; Electron Spin Resonance Spectroscopy; Ferrocyanides; Glycerophosphates; Heme; Hemoglobins; Histidine; Humans; Hydrogen-Ion Concentration; Inositol; Ions; Iron; Osmolar Concentration; Oxygen; Phosphates; Polymers; Protein Binding; Ultracentrifugation | 1971 |
Comparative biological chemistry of cobalt hemoglobin.
Topics: Carbon Dioxide; Chloromercuribenzoates; Cobalt; Cyclic N-Oxides; Cysteine; Diphosphoglyceric Acids; Electron Spin Resonance Spectroscopy; Heme; Hemoglobins; Humans; Hydrogen-Ion Concentration; Iron; Kinetics; Ligands; Mathematics; Oxidation-Reduction; Oxygen; Oxyhemoglobins; Potentiometry; Protein Binding; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfhydryl Compounds | 1973 |
Oxidation of ferric porphyrins.
Topics: Chlorides; Cobalt; Electrodes; Electron Spin Resonance Spectroscopy; Heme; Magnetic Resonance Spectroscopy; Models, Structural; Molecular Conformation; Oxidation-Reduction; Peroxidases; Polarography; Potentiometry; Spectrophotometry; Spectrophotometry, Ultraviolet | 1973 |
The reticulocyte-mediated release of iron and bicarbonate from transferrin: effect of metabolic inhibitors.
Topics: Animals; Antimetabolites; Arsenic; Azides; Bicarbonates; Binding Sites; Carbon Radioisotopes; Cobalt; Cyanides; Cycloheximide; Dinitrophenols; Ethylmaleimide; Fluorides; Heme; Iodoacetates; Iron; Iron Radioisotopes; Isoniazid; Oligomycins; Protein Binding; Reticulocytes; Rotenone; Time Factors; Transferrin | 1974 |
Effect of cobalt on the synthesis and degradation of hepatic catalase in vivo.
Topics: Aminolevulinic Acid; Animals; Catalase; Cobalt; Cytosol; Glycine; Heme; Kinetics; Leucine; Liver; Male; Mitochondria, Liver; Rats | 1974 |
Inorganic and metal-organic growth requirements of the genus Bacteroides.
Topics: Animals; Bacteroides; Calcium; Cobalt; Culture Media; Heme; Iron; Ketoglutaric Acids; Magnesium; Manganese; Phosphates; Potassium; Pyrroles; Rumen; Sodium; Species Specificity; Spectrophotometry; Succinates; Sulfates | 1974 |
Coboglobins: cobalt substitution and the nature of the prosthetic group--apoprotein interaction in hemoglobin and myoglobin.
Topics: Animals; Apoproteins; Cattle; Cetacea; Cobalt; Esters; Globins; Heme; Hemoglobins; Humans; Hydrogen-Ion Concentration; Imines; Macromolecular Substances; Mathematics; Methanol; Myoglobin; Organophosphorus Compounds; Oxygen; Protein Binding; Pyridines; Schiff Bases; Spectrophotometry; Thermodynamics | 1972 |
The photooxygenation of metalloporphyrins and metallochlorins.
Topics: Acetates; Bile Pigments; Binding Sites; Cobalt; Copper; Cyanides; Heme; Hydrogen-Ion Concentration; Magnesium; Magnetic Resonance Spectroscopy; Methanol; Organometallic Compounds; Oxidation-Reduction; Photochemistry; Porphyrins; Quaternary Ammonium Compounds; Spectrophotometry; Spectrophotometry, Ultraviolet; Zinc | 1973 |
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity.
Topics: Animals; Bilirubin; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphine Derivatives; Rats; Urea | 1974 |
The availability of iron for haem synthesis in red blood cells.
Topics: Anemia; Animals; Cell Membrane; Chickens; Cobalt; Cytochrome Reductases; Deuterium; Electron Transport; Erythrocytes; Heme; Humans; Iron; Lyases; Male; Mitochondria, Liver; Oxygen Consumption; Phenylhydrazines; Rats; Reticulocytes; Spectrophotometry; Ultrasonics | 1973 |
Stereochemistry of low-spin cobalt porphyrins. I. Structure and bonding in a nitrosylcobalt porphyrin and their bearing on one rational model for the oxygenated protoheme.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cobalt; Computers; Crystallography; Heme; Methods; Models, Structural; Molecular Conformation; Porphyrins; Stereoisomerism; X-Ray Diffraction | 1973 |
Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase.
Topics: Animals; Carbon Monoxide; Cobalt; Copper; Cyanides; Deuterium; Fluorides; Globins; Heme; Hemeproteins; Iron; Ligands; Male; Metalloproteins; Methemoglobin; Microsomes; Microsomes, Liver; Nickel; Oxygenases; Palladium; Porphyrins; Potassium; Rats; Spleen; Structure-Activity Relationship | 1974 |
Ribonuclease activity in the reticulocyte cell-free system.
Topics: Animals; Bacillus subtilis; Cell-Free System; Cobalt; Cold Temperature; Heme; In Vitro Techniques; Liver; Metabolism; Phosphorus Isotopes; Protein Biosynthesis; Rabbits; Reticulocytes; Ribonucleases; Ribosomes; RNA; RNA, Transfer; Yeasts | 1970 |
Thermodyanamics of the reversible oxygenation of amine complexes of cobalt(II) protoporphyrin IX dimethyl ester in a nonagueous medium.
Topics: Amines; Cobalt; Esters; Heme; Methylation; Models, Chemical; Oxygen; Porphyrins; Spectrophotometry; Thermodynamics | 1972 |
Effect of heme compounds on lipid oxidation.
Topics: Chemical Phenomena; Chemistry; Cobalt; Heme; Linoleic Acids; Manganese; Methemoglobin; Oxidation-Reduction; Polarography | 1971 |
Electrical conductivity of some organic materials containing metals.
Topics: Cobalt; Copper; Cytochromes; Electric Conductivity; Electron Transport; Heme; Iron; Organometallic Compounds; Proteins; Tryptophan; Tyrosine | 1971 |
Role of the spleen in iron metabolism.
Topics: Animals; Bone Marrow; Carbon Isotopes; Cobalt; Enzymes; Erythrocytes; Erythropoietin; Glycine; Heme; Hemorrhage; Histones; Iron; Iron Isotopes; Liver; Lyases; Lymphoma, Non-Hodgkin; Lysine; Phenylhydrazines; Porphyrins; Radiation Effects; Rats; Reticulocytes; Spleen | 1969 |
Stimulation of globin synthesis: relative responsiveness of reticulocytes and nucleated erythroid cells.
Topics: Animals; Blood; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Nucleus; Chromatography; Cobalt; Heme; Hemoglobins; Iron; Leucine; Phenylhydrazines; Protein Binding; Pyruvates; Rabbits; Reticulocytes; Transferrin | 1970 |
Induction of hepatic mitochondrial ferrochelatase by phenobarbital.
Topics: Acyltransferases; Animals; Cobalt; Cycloheximide; Enzyme Induction; Heme; Kinetics; Levulinic Acids; Liver; Lyases; Male; Metabolism; Mitochondria, Liver; Nickel; Oxygen; Phenobarbital; Porphyrins; Rats; Succinates | 1970 |
Some features of the reaction between cobaltinitrite and hemoglobin.
Topics: Carbon Monoxide; Chlorides; Cobalt; Ferricyanides; Heme; Hemoglobins; Humans; Indicators and Reagents; Iron; Methemoglobin; Nitrites; Oxidation-Reduction; Oxygen; Oxygen Consumption; Pigments, Biological; Polarography; Potassium; Protein Binding; Sodium; Spectrum Analysis; Time Factors | 1970 |
The stimulation of hemoglobin synthesis by porphyrins.
Topics: Animals; Carbon Isotopes; Cell Nucleus; Cobalt; Copper; Depression, Chemical; Deuterium; Drug Antagonism; Erythrocytes; Globins; Heme; Hemoglobins; Iron; Lead; Leucine; Mercury; Nickel; Organometallic Compounds; Porphyrins; Stimulation, Chemical; Tin | 1970 |
[Study of the ferrochelatase activity of yeast mitochondria].
Topics: Cobalt; Glutathione; Heme; Hot Temperature; Hydrogen-Ion Concentration; Iron; Kinetics; Lyases; Mitochondria; Nickel; Phospholipids; Porphyrins; Saccharomyces; Zinc | 1968 |
The inhibition of heme and globin synthesis by cobalt in rabbit reticulocytes and bone marrow.
Topics: Amino Acids; Animals; Blood Proteins; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Chromatography, Gel; Cobalt; Globins; Glycine; Heme; Hemoglobins; In Vitro Techniques; Kinetics; Leucine; Levulinic Acids; Peptide Biosynthesis; Rabbits; Reticulocytes; Valine | 1968 |
Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles.
Topics: Autoradiography; Carbon Isotopes; Catalysis; Chelating Agents; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Cobalt; Copper; Densitometry; Heme; Hot Temperature; Hydrogen-Ion Concentration; Iron; Kinetics; Linoleic Acids; Manganese; Metals; Peroxides; Proteins; Spectrophotometry; Ultraviolet Rays | 1969 |
Regulation of heme biosynthesis in Neurspora crassa.
Topics: Acyltransferases; Amino Acids; Cobalt; Depression, Chemical; Enzyme Induction; Enzyme Repression; Feedback; Growth Substances; Heme; Hemoglobins; Hydro-Lyases; Iron; Levulinic Acids; Neurospora; Porphyrins; Stimulation, Chemical; Zinc | 1969 |
Cobalt toxicity and iron metabolism in Neurospora crassa.
Topics: Catalase; Cobalt; Glycine; Heme; In Vitro Techniques; Iron Isotopes; Neurospora; Porphyrins | 1966 |
[Evaluation of the cobalt content of the heme of rats treated with cobaltous chloride].
Topics: Anemia, Hemolytic; Animals; Cobalt; Heme; In Vitro Techniques; Rats | 1966 |
Determination of trace amounts of cobalt in haemin by neutron activation analysis.
Topics: Activation Analysis; Animals; Cattle; Chlorides; Cobalt; Cobalt Isotopes; Heme; In Vitro Techniques; Neutrons | 1967 |
Regulation of rat hepatic delta-aminolevulinic acid synthetase and heme oxygenase activities: evidence for control by heme and against mediation by prosthetic iron.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cobalt; Deferoxamine; Dextrans; Edetic Acid; Heme; Heme Oxygenase (Decyclizing); Iron-Dextran Complex; Kinetics; Liver; Male; Mixed Function Oxygenases; Protoporphyrins; Rats | 1983 |
Electron paramagnetic resonance crystallography of 17O-enriched oxycobaltomyoglobin: stereoelectronic structure of the cobalt dioxygen system.
Topics: Animals; Cobalt; Electron Spin Resonance Spectroscopy; Heme; Myoglobin; Oxygen Isotopes; Protein Conformation; Temperature; Whales | 1980 |
Freezing induced change in ligand orientation in oxycobalt-myoglobin.
Topics: Animals; Cobalt; Crystallography; Electron Spin Resonance Spectroscopy; Freezing; Heme; Ligands; Myoglobin; Oxygen; Whales | 1980 |
Studies on Scapharca hemoglobins. Properties of the dimeric protein reconstituted with Fe- or Co-porphyrin.
Topics: Apoproteins; Bivalvia; Cobalt; Electron Spin Resonance Spectroscopy; Globins; Heme; Hemin; Hemoglobins; Iron; Macromolecular Substances; Oxygen; Spectrum Analysis | 1982 |
1H electron-nuclear double resonance of cobalt hemoglobin.
Topics: Cobalt; Electron Spin Resonance Spectroscopy; Heme; Hemoglobin A; Humans; Magnetic Resonance Spectroscopy; Protein Binding; Protein Conformation | 1982 |
Effects of induction of heme oxygenase by cobalt and tin on the in vivo degradation of myoglobin.
Topics: Animals; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Myoglobin; Rats; Rats, Inbred Strains; Tin | 1984 |
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver.
Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Triazoles | 1983 |
Growth cycle-dependent overproduction and accumulation of protoporphyrin IX in Tetrahymena: effect of heavy metals.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Cycle; Cobalt; Heme; Porphyrins; Protoporphyrins; Tetrahymena pyriformis; Tin | 1982 |
Resonance Raman studies of Co-O2 and O-O stretching vibrations in oxy-cobalt hemes.
Topics: Animals; Cobalt; Heme; Molecular Conformation; Myoglobin; Oxygen; Porphyrins; Spectrum Analysis, Raman; Whales | 1983 |
Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminolaevulinate synthase by manganese in the rat brain.
Topics: 5-Aminolevulinate Synthetase; Animals; Brain; Cobalt; Heme; Heme Oxygenase (Decyclizing); Liver; Male; Manganese; Porphyrins; Rats; Tissue Distribution | 1980 |
Potent heme-degrading action of antimony and antimony-containing parasiticidal agents.
Topics: 5-Aminolevulinate Synthetase; Animals; Anti-Infective Agents; Antimony; Cobalt; Cysteine; Deferoxamine; Dose-Response Relationship, Drug; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Rats; Time Factors; Zinc | 1981 |
[Activity of key enzymes of heme synthesis and degradation and contents of cytochromes b5 and P-450 in rat liver].
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Kinetics; Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1981 |
Control of delta-aminolaevulinate synthase and haem oxygenase in chronic-iron-overloaded rats.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Thyroid hormone regulation of heme oxidation in the liver.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Female; Heme; Heme Oxygenase (Decyclizing); Liver; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Oxidation-Reduction; Rats; Thyroidectomy; Time Factors; Triiodothyronine; Triiodothyronine, Reverse | 1982 |
Structure of human deoxy cobalt haemoglobin.
Topics: Binding Sites; Cobalt; Heme; Hemoglobins; Humans; Iron; Models, Molecular; Protein Binding; Protein Conformation; X-Ray Diffraction | 1982 |
Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin.
Topics: Animals; Cells, Cultured; Chick Embryo; Cobalt; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Liver; Male; Microsomes, Liver; Porphyrins; Proteins; Protoporphyrins; Rats; Rats, Inbred Strains | 1982 |
Effects of cobalt chloride on haem synthesis in isolated hepatocytes.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Cobalt; Heme; Liver; Metalloporphyrins; Rats | 1981 |
The stimulation of globin synthesis by cobalt in reticulocytes with inhibited heme synthesis.
Topics: Animals; Cobalt; Globins; Heme; Heptanoates; Isoniazid; Keto Acids; Kinetics; Protein Biosynthesis; Rabbits; Reticulocytes | 1981 |
Evidence for heme pi cation radical species in compound I of horseradish peroxidase and catalase.
Topics: Animals; Catalase; Cations; Cattle; Chemical Phenomena; Chemistry; Circular Dichroism; Cobalt; Free Radicals; Heme; Horseradish Peroxidase; Liver; Magnetics; Molecular Conformation; Peroxidases; Porphyrins | 1981 |
Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells.
Topics: Animals; Cadmium; Cadmium Chloride; Carrier Proteins; Cell Line; Cells, Cultured; Chlorides; Cobalt; Cytosol; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Heme-Binding Proteins; Hemeproteins; Kinetics; Liver; Liver Neoplasms, Experimental; Mice; Molecular Sequence Data; Rats; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Degradation of heme IX in rats pretreated with cobaltous chloride. A study in isolated perfused liver.
Topics: Animals; Bile; Bilirubin; Cobalt; Glucuronosyltransferase; Heme; In Vitro Techniques; Liver; Male; Molecular Structure; Perfusion; Rats; Rats, Wistar; Reference Values | 1994 |
Cobaltous chloride-mediated induction of rat hepatic tryptophan 2,3-dioxygenase: implications for the use of the enzyme to probe the hepatic free heme pool.
Topics: Adrenal Glands; Adrenalectomy; Animals; Apoenzymes; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Liver; Male; Metals; Rats; Rats, Sprague-Dawley; Tryptophan Oxygenase | 1994 |
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
Topics: Animals; Cobalt; Cycloheximide; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation; Genes, fos; Genes, jun; Heme; Humans; Hypoxia; In Vitro Techniques; Lymphokines; Oxygen; Rats; RNA, Messenger; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1994 |
Coexpression of erythropoietin and heme oxygenase genes in Hep3B cells.
Topics: Carcinoma, Hepatocellular; Cobalt; Erythropoietin; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Humans; Liver Neoplasms; Metalloporphyrins; Protoporphyrins; RNA, Messenger; Tumor Cells, Cultured | 1993 |
Ligand diffusion in the distal heme pocket of myoglobin. A primary determinant of geminate rebinding.
Topics: Animals; Cobalt; Diffusion; Heme; Iron; Kinetics; Ligands; Mutation; Myoglobin; Nitric Oxide; Oxygen; Whales | 1993 |
Reaction of the Hansenula anomala flavocytochrome b2 and cytochrome b2 core with inorganic outer sphere redox compounds.
Topics: Cobalt; Edetic Acid; Electron Transport; Ferricyanides; Fungal Proteins; Heme; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Organometallic Compounds; Oxidation-Reduction; Phenanthrolines; Pichia; Solubility; Water | 1995 |
Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells.
Topics: Animals; Cells, Cultured; Chick Embryo; Cobalt; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt.
Topics: Chromosome Mapping; Cobalt; Culture Media; Cysteine; Heme; Iron; Methionine; Methyltransferases; Mutagenesis; Operon; Oxidation-Reduction; Phenotype; Point Mutation; Salmonella typhimurium; Sulfites; Vitamin B 12 | 1996 |
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorides; Cobalt; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferric Compounds; Gene Expression Regulation, Enzymologic; Heme; Hemin; Liver; Molecular Weight; Nuclear Proteins; Phenobarbital; Protoporphyrins; Rats; RNA, Messenger; Steroid Hydroxylases; Transcription, Genetic | 1997 |
A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis.
Topics: Cobalt; Corrinoids; Cysteine; Escherichia coli; Gene Deletion; Genes, Bacterial; Genetic Complementation Test; Heme; Methyltransferases; Mutagenesis, Site-Directed; Porphyrins; Salmonella typhimurium; Species Specificity; Spectrophotometry, Ultraviolet; Vitamin B 12 | 1997 |
Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures.
Topics: Animals; Arsenites; Cells, Cultured; Chick Embryo; Cobalt; Gene Expression Regulation; Genes, Reporter; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; L-Lactate Dehydrogenase; Liver; Membrane Proteins; RNA; Sodium Compounds; Transfection | 1997 |
EPR characterization of axial bond in metal center of native and cobalt-substituted guanylate cyclase.
Topics: Animals; Cattle; Cobalt; Electron Spin Resonance Spectroscopy; Guanylate Cyclase; Heme; Histidine; Iron; Kinetics; Nitric Oxide; Nitrites; Nitrogen; Spectrum Analysis, Raman | 1999 |
Cobalt deficiency effects on trace elements, hormones and enzymes involved in energy metabolism of cattle.
Topics: Animals; Blood Glucose; Cattle; Cobalt; Electron Transport Complex IV; Energy Metabolism; Folic Acid; Glucosephosphate Dehydrogenase; Heme; Iron; Liver; Male; Nickel; Thyroid Hormones; Trace Elements; Triiodothyronine; Zinc | 1999 |
Heme protein dynamics revealed by geminate nitric oxide recombination in mutants of iron and cobalt myoglobin.
Topics: Amino Acid Substitution; Animals; Cobalt; Heme; Iron; Isoleucine; Mutagenesis, Site-Directed; Myoglobin; Nitric Oxide; Phenylalanine; Thermodynamics; Whales | 1999 |
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.
Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine | 1999 |
Tissue variant effects of heme inhibitors on the mouse cytochrome c oxidase gene expression and catalytic activity of the enzyme complex.
Topics: Adenosine Triphosphate; Animals; Brain; Catalysis; Cobalt; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex IV; Enzyme Induction; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Heptanoates; Iron; Kidney; Mice; Mitochondria; Mitochondria, Liver; Multienzyme Complexes; Organ Specificity; Porphobilinogen Synthase; RNA, Messenger | 1999 |
Oxygen induction of epithelial Na(+) transport requires heme proteins.
Topics: Amiloride; Animals; Biological Transport; Carrier Proteins; Cobalt; Epithelial Cells; Epithelial Sodium Channels; Fetus; Heme; Hemeproteins; Iron; Iron Chelating Agents; Iron-Binding Proteins; Lung; Metals; Oxygen; Rats; Rats, Wistar; RNA, Messenger; Sodium; Sodium Channels; Transferrin-Binding Proteins | 2000 |
Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity.
Topics: Adenoviridae; Animals; Cobalt; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gene Transfer Techniques; Genetic Vectors; Heme; Heme Oxygenase (Decyclizing); Humans; Kidney; Liver; Male; Oxygenases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transduction, Genetic | 2000 |
Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures.
Topics: Animals; Arteries; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Blotting, Northern; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; Fluorescent Dyes; Heme; Hepatocytes; Immunoblotting; Male; Nucleic Acid Synthesis Inhibitors; Oxygen; Rats; Rats, Wistar; Rhodamine 123; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Veins | 2000 |
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Blotting, Western; Cattle; Cell Line; Cobalt; Dactinomycin; Deferoxamine; Dimerization; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia; Interferon-gamma; Leucine Zippers; Luciferases; Membrane Proteins; Models, Genetic; Oxidative Stress; Oxygen; Promoter Regions, Genetic; Rats; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
The effect of cobalt on heme synthesis by bone marrow in vitro.
Topics: Bone Marrow; Cobalt; Heme; Hemoglobins; Humans; In Vitro Techniques | 1956 |
The influence of chelation in determining the reactivity of the iron in hemoproteins. and the cobalt in vitamin B12 derivatives.
Topics: Chelating Agents; Cobalt; Heme; Iron; Vitamin B 12 | 1960 |
[Effect of cobalt and copper on the quantitative relation of globin and hematin in the blood of white rats].
Topics: Animals; Cobalt; Copper; Globins; Heme; Hemin; Hemoglobins; Rats; Respiratory Transport | 1962 |
[ON METAL PROTOPORPHYRINS AND THEIR COMPLEXES. I. DEMONSTRATION, CHEMICAL AND MAGNETIC PROPERTIES OF COBALT AND MANGANESE PROTOPORPHYRINS].
Topics: Chemical Phenomena; Chemistry; Cobalt; Heme; Hydrogen-Ion Concentration; Magnetic Phenomena; Manganese; Metals; Oxidation-Reduction; Protoporphyrins; Research; Spectrophotometry | 1963 |
THE INTERACTION OF PORPHYRINS AND METALLOPORHYRINS WITH APOCYTOCHROME BETA-5.
Topics: Chemical Phenomena; Chemistry; Chromatography; Cobalt; Copper; Cytochromes; Deuterium; Heme; Hydrogen-Ion Concentration; Magnesium; Nickel; Porphyrins; Pyrroles; Research; Spectrophotometry; Trypsin; Urea | 1964 |
[EFFECTS OF HYDROCYANIC ACID AND HYDROGEN SULFIDE AND POSSIBILITIES FOR TREATMENT OF POISONING].
Topics: Animals; Antidotes; Blood Pressure; Blood Pressure Determination; Central Nervous System Stimulants; Cobalt; Edetic Acid; Epinephrine; Guinea Pigs; Heme; Histidine; Hydrogen Cyanide; Hydrogen Sulfide; Lobeline; Methemoglobin; Nitrites; Oxygen; Pentylenetetrazole; Poisoning; Rats; Research; Sulfides; Thiocyanates; Thiosulfates; Toxicology; Vagotomy | 1964 |
ENZYMIC FORMATION OF HAEMS AND OTHER METALLOPORPHYRINS.
Topics: Animals; Cadmium; Cobalt; Enzymes; Erythrocytes; Heme; Ions; Iron; Magnesium; Manganese; Mercury; Metabolism; Metalloporphyrins; Metals; Nickel; Porphyrins; Poultry; Research; Rhodopseudomonas; Thiobacillus; Zinc | 1964 |
HAEM SYNTHASE AND COBALT PORPHYRIN SYNTHASE IN VARIOUS MICRO-ORGANISMS.
Topics: Biochemical Phenomena; Biochemistry; Chloromercuribenzoates; Clostridium; Cobalt; Enzyme Inhibitors; Enzymes; Ethylmaleimide; Ferrochelatase; Glutathione; Heme; Hydrogen-Ion Concentration; Iron; Micrococcus; Nitric Oxide Synthase; Porphyrins; Research | 1965 |
Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin.
Topics: Amino Acid Sequence; Animals; Biliverdine; Candida albicans; Chromatography, High Pressure Liquid; Cobalt; DNA, Complementary; Gene Expression Regulation, Enzymologic; Genes, Reporter; Heme; Heme Oxygenase (Decyclizing); Hemin; Hemoglobins; Humans; Hydrolysis; Iron; Luciferases; Mice; Models, Chemical; Molecular Sequence Data; Mutation; Plasmids; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA; RNA, Messenger; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Transcription, Genetic; Trypanosoma brucei brucei; Virulence | 2004 |
Structure and dynamics of dioxygen bound to cobalt and iron heme.
Topics: Binding Sites; Cobalt; Computer Simulation; Ferric Compounds; Heme; Histidine; Imidazoles; Iron; Models, Molecular; Myoglobin; Oxides; Oxygen; Porphyrins; Protein Conformation | 2006 |
De novo design of DeltaF -containing heme-binding peptides.
Topics: Amino Acid Sequence; Cobalt; Coproporphyrins; Heme; Histidine; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic | 2007 |
Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide.
Topics: Acridines; Adrenergic beta-Agonists; Animals; Blotting, Western; Cattle; Cobalt; Enzyme Activation; Enzyme Induction; Guanylate Cyclase; Heme; Heme Oxygenase-1; Isoproterenol; Luminescence; Mesoporphyrins; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Organ Culture Techniques; Protoporphyrins; Pulmonary Artery; Spermine; Superoxides | 2008 |
Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.
Topics: Amino Acid Sequence; Bacillus megaterium; Bacterial Proteins; Catalytic Domain; Cobalt; Copper; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Heme; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases; Protein Structure, Secondary; Sequence Homology, Amino Acid; Uroporphyrins | 2008 |
Resonance Raman spectroscopic studies of hydroperoxo derivatives of cobalt-substituted myoglobin.
Topics: Animals; Cobalt; Heme; Horses; Myoglobin; Spectrum Analysis, Raman | 2008 |
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.
Topics: Allosteric Site; Cobalt; Cystathionine beta-Synthase; Escherichia coli; Heme; Homocysteine; Humans; Manganese; Metals; Methylamines; Porphyrins; Protein Denaturation; Protein Folding; Recombinant Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae | 2008 |
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.
Topics: Blotting, Northern; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Gene Expression Regulation, Enzymologic; Heme; Humans; Hydroxymethylbilane Synthase; Isoenzymes; Jurkat Cells; K562 Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Messenger; Tetrapyrroles; Uroporphyrinogen III Synthetase | 2008 |
Dipyridamole inhibits cobalt chloride-induced osteopontin expression in NRK52E cells.
Topics: Animals; Biocatalysis; Carbon Monoxide; Cell Line; Cobalt; Dipyridamole; Enzyme Induction; Epithelial Cells; Gene Expression Regulation; Heme; Heme Oxygenase-1; Kidney Tubules; Mitogen-Activated Protein Kinase Phosphatases; Osteopontin; Rats; Reactive Oxygen Species | 2009 |
Product release rather than chelation determines metal specificity for ferrochelatase.
Topics: Cadmium; Cobalt; Crystallography, X-Ray; Ferrochelatase; Heme; Humans; Iron; Lead; Mercury; Metals; Nickel; Protein Structure, Secondary; Protoporphyrins; Substrate Specificity; Zinc | 2009 |
Cardiac delta-aminolevulinic acid synthetase activity. Effects of fasting, cobaltous chloride and hemin.
Topics: 5-Aminolevulinate Synthetase; Animals; Cobalt; Fasting; Guinea Pigs; Heart; Heme; Kinetics; Male; Mice; Myocardium; Rabbits; Rats; Rats, Sprague-Dawley | 1980 |
In vivo production of catalase containing haem analogues.
Topics: Catalase; Cobalt; Enterococcus faecalis; Gallium; Heme; Hemeproteins; Metalloporphyrins; Protoporphyrins | 2010 |
Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.
Topics: Circular Dichroism; Cloning, Molecular; Cobalt; Coordination Complexes; Cystathionine beta-Synthase; Cysteine; Escherichia coli; Heme; Hemeproteins; Histidine; Humans; Hydrogen-Ion Concentration; Ligands; Models, Molecular; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Spectrophotometry, Atomic | 2011 |
The Porphyromonas gingivalis HmuY haemophore binds gallium(iii), zinc(ii), cobalt(iii), manganese(iii), nickel(ii), and copper(ii) protoporphyrin IX but in a manner different to iron(iii) protoporphyrin IX.
Topics: Absorption; Bacterial Proteins; Circular Dichroism; Cobalt; Copper; Gallium; Heme; Hemeproteins; Histidine; Ligands; Magnetic Resonance Spectroscopy; Manganese; Metals; Mutant Proteins; Nickel; Porphyromonas gingivalis; Protein Binding; Protoporphyrins; Spectrophotometry, Ultraviolet; Zinc | 2013 |
Relaxation analysis of ligand binding to the myoglobin reconstituted with cobaltic heme.
Topics: Animals; Binding Sites; Cobalt; Cyanides; Heme; Imidazoles; Ligands; Myoglobin; Oxidation-Reduction; Protein Binding; Pyridines; Whales | 2013 |
Electronic structure and ligand vibrations in FeNO, CoNO, and FeOO porphyrin adducts.
Topics: Cobalt; Electrons; Heme; Iron; Models, Molecular; Nitric Oxide; Porphyrins | 2013 |
Usefulness of myoglobin containing cobalt heme cofactor in designing a myoglobin-based artificial oxygen carrier.
Topics: Animals; Cobalt; Drug Design; Heme; Myoglobin; Oxygen | 2014 |
Carbon nitride nanosheet-supported porphyrin: a new biomimetic catalyst for highly efficient bioanalysis.
Topics: Biomimetics; Biotinylation; Carbon; Catalysis; Cobalt; Computer Simulation; DNA; DNA, Complementary; Electrochemistry; Heme; Hemoglobins; Humans; Luminescence; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nanostructures; Nanotechnology; Nitriles; Oligonucleotides; Photoelectron Spectroscopy; Porphyrins; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Streptavidin; Vitamin B 12 | 2015 |
Fractional transfer of a free unpaired electron to overcome energy barriers in the formation of Fe(4+) from Fe(3+) during the core contraction of macrocycles: implication for heme distortion.
Topics: Catalysis; Cobalt; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Heme; Ions; Iron; Models, Molecular; Molecular Conformation; Molecular Structure; Oxidation-Reduction; Oxygen; Porphyrins | 2015 |
Memetic algorithms for ligand expulsion from protein cavities.
Topics: Algorithms; Camphor; Camphor 5-Monooxygenase; Cobalt; Diffusion; Heme; Hydro-Lyases; Ligands; Molecular Dynamics Simulation; Niacinamide; Protein Binding; Quinuclidinyl Benzilate; Receptor, Muscarinic M2 | 2015 |
Unraveling Binding Effects of Cobalt(II) Sepulchrate with the Monooxygenase P450 BM-3 Heme Domain Using Molecular Dynamics Simulations.
Topics: Binding Sites; Cobalt; Cytochrome P-450 Enzyme System; Electron Transport; Heme; Molecular Dynamics Simulation; Protein Structure, Tertiary | 2016 |
Intraprotein transmethylation via a CH3-Co(iii) species in myoglobin reconstituted with a cobalt corrinoid complex.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Sequence; Biomimetic Materials; Cobalt; Corrinoids; Heme; Kinetics; Methylation; Models, Molecular; Myoglobin; Organometallic Compounds; Protein Conformation | 2016 |
Crystal Structures and Coordination Behavior of Aqua- and Cyano-Co(III) Tetradehydrocorrins in the Heme Pocket of Myoglobin.
Topics: Cobalt; Crystallography, X-Ray; Cyanides; Heme; Hydrogen-Ion Concentration; Metalloporphyrins; Models, Molecular; Molecular Structure; Myoglobin; Organometallic Compounds; Water | 2016 |
Chiral Selectivity in Inter-reactant Recognition and Electron Transfer of the Oxidation of Horse Heart Cytochrome c by Trioxalatocobaltate(III).
Topics: Animals; Cobalt; Coordination Complexes; Cytochromes c; Electron Transport; Heme; Horses; Kinetics; Models, Molecular; Oxalic Acid; Oxidation-Reduction; Stereoisomerism | 2016 |
Cobalt tetradehydrocorrins coordinated by imidazolate-like histidine in the heme pocket of horseradish peroxidase.
Topics: Cobalt; Coordination Complexes; Corrinoids; Heme; Histidine; Horseradish Peroxidase; Imidazoles; Models, Molecular; Molecular Conformation | 2017 |
Crystallographic insights into a cobalt (III) sepulchrate based alternative cofactor system of P450 BM3 monooxygenase.
Topics: Bacillus megaterium; Bacterial Proteins; Catalytic Domain; Cloning, Molecular; Cobalt; Coenzymes; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Electrons; Escherichia coli; Gene Expression; Heme; Models, Molecular; NADP; NADPH-Ferrihemoprotein Reductase; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Substrate Specificity; Zinc | 2018 |
Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism.
Topics: Binding Sites; Cobalt; Crystallization; Crystallography, X-Ray; Heme; Manganese; Models, Molecular; Oxidation-Reduction; Oxidoreductases; X-Ray Absorption Spectroscopy | 2017 |
A glance at…antioxidant and antiinflammatory properties of dietary cobalt.
Topics: Anti-Inflammatory Agents; Antioxidants; Cobalt; Diet; Health Promotion; Heme; Humans | 2018 |
Proton mediated spin state transition of cobalt heme analogs.
Topics: Biocatalysis; Cobalt; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Histidine; Hydrogen-Ion Concentration; Imidazoles; Iron; Ligands; Oxidation-Reduction; Protons | 2019 |
De novo biosynthesis of a nonnatural cobalt porphyrin cofactor in
Topics: Biocatalysis; Cobalt; Escherichia coli; Escherichia coli Proteins; Heme; Iron; Metalloporphyrins; Metals; Myoglobin; Porphyrins; Protoporphyrins | 2021 |
Molecular Dynamics of Cobalt Protoporphyrin Antagonism of the Cancer Suppressor REV-ERBβ.
Topics: Binding Sites; Chemistry, Pharmaceutical; Cobalt; Heme; Humans; Iron; Kinetics; Ligands; Metals; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Peptides; Photosensitizing Agents; Porphyrins; Protein Binding; Protoporphyrins; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Signal Transduction | 2021 |
Diheme cytochromes: Effect of mixed-axial ligation on the electronic structure and electrochemical properties with cobalt porphyrin dimer.
Topics: Cobalt; Cytochromes; Heme; Imidazoles; Ligands; Porphyrins; Pyridines | 2023 |
Functional Characterization of the Co
Topics: Cobalt; Heme; Hemin; Homeostasis; Iron; Sinorhizobium meliloti; Symporters | 2023 |