Compounds > cobalt
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cobalt and deferoxamine

cobalt has been researched along with deferoxamine in 106 studies

Research

Studies (106)

TimeframeStudies, this research(%)All Research%
pre-19909 (8.49)18.7374
1990's24 (22.64)18.2507
2000's56 (52.83)29.6817
2010's16 (15.09)24.3611
2020's1 (0.94)2.80

Authors

AuthorsStudies
Fehr, J1
Corbett, WE; Ludwig, J; Sorbie, J; Valberg, LS1
Ganesh, KN; Joshi, RR1
Beug, H; Birnstiel, ML; Cotten, M; Kirlappos, H; Längle-Rouault, F; Mechtler, K; Wagner, E; Zenke, M1
MacDonald, RA; MacSween, RN; Pechet, GS1
Friedberg, KD; Grützmacher, J; Lendle, L1
Hefter, K; Kwock, L; Lin, PS; Misslbeck, G1
Kitchin, KT1
Bonkowsky, HL; Brinckerhoff, CE; Harris, ED; Okazaki, I; Sinclair, JF; Sinclair, PR1
Drummond, GS; Kappas, A1
Leong, J; Yang, CC1
Ebert, BL; Firth, JD; Gleadle, JM; Ratcliffe, PJ1
Bauer, C; Jung, HH; Marti, HH; Pfeilschifter, J1
Semenza, GL; Wang, GL1
Ebert, BL; Gleadle, JM; Ratcliffe, PJ1
Jiang, JJ; Liu, KJ; Mao, Y; Shi, X1
Bartlett, SM; Ebert, BL; Gleadle, JM; O'Rourke, JF; Poulton, J; Ratcliffe, PJ1
Ebert, BL; Nagao, M; Pugh, CW; Ratcliffe, PJ1
Eckardt, KU; Gess, B; Göpfert, T; Kurtz, A1
Freimann, S; Jungermann, K; Kietzmann, T; Roth, U1
Acker, H; Ehleben, W; Fandrey, J; Kummer, W; Porwol, T1
Acker, H; Ehleben, W; Fandrey, J; Frede, S; Jelkmann, W; Porwol, T1
Beck, I; Caro, J; Salceda, S; Srinivas, V1
Farber, HW; Graven, KK; McDonald, RJ1
An, WG; Blagosklonny, MV; Kanekal, M; Maltepe, E; Neckers, LM; Simon, MC1
Allen, WE; Eckardt, KU; Gatter, KC; Harris, AL; Maxwell, PH; Pugh, CW; Ratcliffe, PJ; Talks, KL; Turley, H; Wiesener, MS; Willam, C; Wood, SM1
Agani, F; Semenza, GL1
Aikou, T; Akiyama, S; Furukawa, T; Ishitsuka, K; Kitazono, M; Miyadera, K; Takao, S; Takebayashi, Y; Tani, A; Yamada, Y1
Bunn, HF; Goldberg, MA; Gu, J; Huang, LE; Willmore, WG1
Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T1
Daghman, NA; Elder, GE; Lappin, TR; Maxwell, AP; Savage, GA; Winter, PC1
Bianchi, L; Cairo, G; Tacchini, L1
Baraban, JM; Hall, D; Lin, KI; Marquis, JC; Miller, MP; O'Donovan, K; Ratan, RR; Ryu, H; Semenza, GL; Zaman, K1
Kim, JE; Sheen, YY2
Fujii-Kuriyama, Y; Katayose, D; Kitamuro, T; Nakayama, M; Shibahara, S; Shirato, K; Takahashi, K; Yasumoto, K1
Chandel, NS; Feliciano, CE; McClintock, DS; Melendez, JA; Rodriguez, AM; Schumacker, PT; Wood, TM1
Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T; Ziemann, C1
Clark, IM; Garcia, PL; Norman, JT1
Brüne, B; Fandrey, J; Sandau, KB1
Dong, Z; Force, T; Nishiyama, J; Patel, Y; Saikumar, P; Semenza, GL; Venkatachalam, MA; Wang, J1
Asara, JM; Ivan, M; Kaelin , WG; Kim, W; Kondo, K; Lane, WS; Ohh, M; Salic, A; Valiando, J; Yang, H1
Aoki, Y; Blauvelt, A; Davis, DA; Read-Connole, EL; Rinderknecht, AS; Tosato, G; Yarchoan, R; Zoeteweij, JP1
Beitner-Johnson, D; Kim, HW; Kim, R; Millhorn, DE; Seta, KA1
Fukuda, K; Hirota, K; Itoh, T; Namba, T; Semenza, GL1
Armstead, V; Caro, J; Leshchinsky, I; Minchenko, A; Opentanova, I; Sang, N; Srinivas, V1
Hida, W; Kitamuro, T; Murakami, O; Nakayama, M; Shibahara, S; Shirato, K; Takahashi, K; Totsune, K1
Furusawa, S; Iizuka, Y; Sakaguchi, S; Satoh, S; Takayanagi, M1
Caniggia, I; De Marco, CS1
Denton, M; Dong, Z; Gu, S; Li, S; Nishiyama, J; Qiang, M; Venkatachalam, MA; Yi, X1
Bois-Joyeux, B; Chauvet, C; Danan, JL1
Chan, DA; Denko, NC; Giaccia, AJ; Sutphin, PD1
Fujita, H; Furuyama, K; Hattori, T; Hida, W; Igarashi, K; Kitamuro, T; Nakayama, M; Ogawa, K; Shibahara, S; Shirato, K; Sun, J; Takahashi, K; Takeda, K; Udono-Fujimori, R1
Ferguson, T; Hilliard, G; Millhorn, DE; Yuan, Y1
Dötsch, J; Fusch, C; Knerr, I; Linnemann, K; Meissner, U; Rascher, W; Weigel, C1
Ameri, K; Hai, T; Harris, AL; Lewis, CE; Raida, M; Sowter, H1
Gess, B; Hofbauer, KH; Katschinski, D; Kurtz, A; Lohaus, C; Meyer, HE1
Caro, J; Minchenko, O; Opentanova, I1
Chavez, JC; LaManna, JC; Pichiule, P1
Clerici, C; Clottes, E; Couette, S; Matthay, MA; Mounier, R; Rossignol, F; Uchida, T1
Chen, SD; Hsu, CY; Ju, TC; Xu, JM; Yang, DI; Yang, YT1
Fujita, K; Inui, H; Nagao, K; Naito, M; Nakanishi, I; Nakano, Y; Tsuruo, T; Yamaji, R1
Nomura, Y; Shimizu, T; Uehara, T1
Bartrons, R; Caro, J; Duran, J; Gómez, M; Kong, X; Navarro-Sabaté, A; Obach, M; Perales, JC; Rosa, JL; Ventura, F1
Esumi, H; Minchenko, D; Minchenko, O; Ogura, T; Opentanova, I1
Ju, TC; Yang, DI; Yang, YT1
Hirsilä, M; Kivirikko, KI; Koivunen, P; Myllyharju, J; Seeley, T; Xu, L1
Hogenesch, JB; LaPres, JJ; Phillips, JM; Vengellur, A1
Bockmühl, U; Fuchs, J; Gross, J; Jahnke, V; Kietzmann, T; Machulik, A1
Tamm, I1
Chen, GQ; Huang, Y; Jiang, Y; Peng, ZG; Wu, YL; Yan, H; Yu, Y; Zhao, Q; Zhu, YS1
Chen, GQ; Guo, M; Jiang, Y; Liu, W; Song, LP; Yu, Y1
Guyton, RA; Halkos, ME; Jiang, R; Kanter, KR; Kerendi, F; Kin, H; Kirshbom, PM; Vinten-Johansen, J; Wang, NP; Zhao, ZQ1
Harten, SK; Haskard, DO; Johns, M; Kinderlerer, AR; Lidington, EA; Mason, JC; Maxwell, PH; Steinberg, R1
Bonanou, S; Georgatsou, E; Liakos, P; Simos, G; Triantafyllou, A; Tsakalof, A1
Baumann, MU; Illsley, NP; Zamudio, S1
Caniggia, I; Groenman, FA; Post, M; Rutter, M; Tibboel, D; Wang, J1
Asikainen, TM; White, CW1
Halliwell, B; Lim, HY; Mukhopadhyay, A; Phan, TT; Vincent, AS; Wong, KP1
Akwa, Y; Baulieu, EE; Dessouroux, A1
Shu, B; Yang, HT; Yang, WW1
Beart, PM; Callaway, JK; Jones, NM; Kardashyan, L; Lee, EM1
Soutto, M; Sriram, S; Yao, SY2
Cízková, A; Demont, J; Franssen-van Hal, NL; Godinot, C; Hervouet, E; Houstek, J; Ivánek, R; Keijer, J; Kmoch, S; Pecina, P; Simonnet, H; Vojtísková, A1
Furuyama, K; Sassa, S; Shibahara, S; Vargas, PD1
Adler, I; Arend, M; Flippin, LA; Manaenko, A; Milosevic, J; Schwarz, J; Schwarz, SC; Storch, A; Walkinshaw, G1
Berberat, PO; Friess, H; Hennig, R; Künzli, BM; Meuer, SC; Mitkus, T; Nobiling, R; Nuhn, P; Ramanauskas, T1
Huang, Y; Li, Y; Liang, Y; Lu, H; Shu, M; Tang, J; Yan, G; Zhou, Y1
Wang, Z; Yin, D; Zhang, Z1
Chang, CH; Chen, YC; Fan, SC; Huang, CH; Liu, C; Tsai, AL; Wu, CC1
Beilfuss, A; Canbay, A; Gerken, G; Mayer, A; Schick, RR; Vaupel, P; Westphal, S; Wree, A1
Agis, H; Gruber, R; Watzek, G1
Teng, H; Wang, R; Wu, B; Wu, L; Yang, G1
Agis, H; Cvikl, B; Gruber, R; Müller, HD; Watzek, G1
Borcar, A; Hand, SC; Menze, MA; Toner, M1
Barman-Aksözen, J; Béguin, C; Dogar, AM; Minder, EI; Schneider-Yin, X1
Chan, EC; Dusting, GJ; Higuchi, M; Jiang, F; Liu, GS; Peshavariya, HM1
Elliott, JP; Jones, SM; Novak, AE1
Befani, C; Georgoulias, P; Gkotinakou, IM; Hu, CJ; Liakos, P; Mylonis, I; Simos, G1
Arukwe, A; Olufsen, M1
Hill, MA; Morrison, RA; Rybak-Smith, MJ; Thiebaut, B; Thompson, JM; Townley, HE1
Auner, HW; Ferreira, SA; Foyt, DA; Gentleman, E; Grigoriadis, AE; Ilic, D; Jell, G; Loaiza, S; Taheem, DK1
Agis, H; Janjić, K; Kurzmann, C; Moritz, A; Müller, AS; Oberoi, G; Pensch, M1
Agis, H; Edelmayer, M; Gashi, M; Janjić, K; Moritz, A; Müller, AS1
Barrak, NH; Khajah, MA; Luqmani, YA1

Other Studies

106 other study(ies) available for cobalt and deferoxamine

ArticleYear
[Idiopathic hemochromatosis: current problems in diagnosis and therapy].
    Schweizerische medizinische Wochenschrift, 1979, Apr-28, Volume: 109, Issue:17

    Topics: Adolescent; Adult; Aged; Biopsy; Cobalt; Deferoxamine; Female; Ferritins; Hemochromatosis; Humans; Iron; Liver; Male; Middle Aged; Pedigree

1979
Serum ferritin, cobalt excretion and body iron status.
    Canadian Medical Association journal, 1975, May-17, Volume: 112, Issue:10

    Topics: Adolescent; Adult; Aged; Bone Marrow; Cobalt; Deferoxamine; Female; Ferritins; Hemosiderin; Humans; Iron; Liver; Liver Diseases; Male; Middle Aged

1975
Chemical cleavage of plasmid DNA by Cu(II), Ni(II) and Co(III) desferal complexes.
    Biochemical and biophysical research communications, 1992, Jan-31, Volume: 182, Issue:2

    Topics: Cobalt; Copper; Deferoxamine; DNA, Bacterial; Free Radical Scavengers; Free Radicals; Hydrolysis; Hydroxides; Hydroxyl Radical; Nickel; Plasmids

1992
Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:11

    Topics: Chloroquine; Cobalt; Deferoxamine; Heptanoates; Humans; In Vitro Techniques; Luciferases; Monensin; Phagocytosis; Polylysine; Porphobilinogen Synthase; Receptors, Transferrin; Transferrin; Transformation, Genetic; Tumor Cells, Cultured

1990
Iron metabolism by reticuloendothelial cells in vitro. Physical and chemical conditions, lipotrope deficiency, and acute inflammation.
    Laboratory investigation; a journal of technical methods and pathology, 1969, Volume: 21, Issue:3

    Topics: Animals; Ascorbic Acid; Cobalt; Copper; Cysteine; Dactinomycin; Deferoxamine; Dinitrophenols; Edetic Acid; Fatty Liver; Fluorides; Fructose; Glucose; Glutathione; Hemochromatosis; Inflammation; Iodoacetates; Iron; Lipotropic Agents; Liver Cirrhosis; Lung; Macrophages; Microscopy, Electron; Potassium Permanganate; Protein Biosynthesis; Puromycin; Rabbits; RNA; Saponins; Sucrose; Surface-Active Agents; Transferrin; Trypsin

1969
[The significance of the speed of action of antidotes in the treatment of cyanide poisoning].
    Archiv fur Toxikologie, 1966, Volume: 22, Issue:3

    Topics: Animals; Antidotes; Cobalt; Cyanides; Deferoxamine; Guinea Pigs; Heart Atria; Rats; Vitamin B 12

1966
Effects of iron, copper, cobalt, and their chelators on the cytotoxicity of bleomycin.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Animals; Bleomycin; Cell Line; Cell Survival; Cobalt; Copper; Cricetinae; Cricetulus; Deferoxamine; Diethyl Pyrocarbonate; Iron; Lung

1983
Regulation of rat hepatic delta-aminolevulinic acid synthetase and heme oxygenase activities: evidence for control by heme and against mediation by prosthetic iron.
    The International journal of biochemistry, 1983, Volume: 15, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cobalt; Deferoxamine; Dextrans; Edetic Acid; Heme; Heme Oxygenase (Decyclizing); Iron-Dextran Complex; Kinetics; Liver; Male; Mixed Function Oxygenases; Protoporphyrins; Rats

1983
Iron increases collagenase production by rabbit synovial fibroblasts.
    The Journal of laboratory and clinical medicine, 1981, Volume: 97, Issue:3

    Topics: Animals; Cell Count; Cobalt; Deferoxamine; Ferric Compounds; Fibroblasts; Guinea Pigs; Iron; Manganese; Microbial Collagenase; Prostaglandins E; Proteins; Rabbits; Synovial Fluid; Tetradecanoylphorbol Acetate

1981
Potent heme-degrading action of antimony and antimony-containing parasiticidal agents.
    The Journal of experimental medicine, 1981, Feb-01, Volume: 153, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Animals; Anti-Infective Agents; Antimony; Cobalt; Cysteine; Deferoxamine; Dose-Response Relationship, Drug; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Rats; Time Factors; Zinc

1981
Production of deferriferrioxamines B and E from a ferroverdin-producing Streptomyces species.
    Journal of bacteriology, 1982, Volume: 149, Issue:1

    Topics: Chlorides; Cobalt; Culture Media; Deferoxamine; Ferric Compounds; Ferrous Compounds; Iron Chelating Agents; Nitroso Compounds; Peptides, Cyclic; Phenols; Streptomyces

1982
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1

    Topics: Angiogenesis Inducing Agents; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line; Chelating Agents; Cobalt; Deferoxamine; Endothelial Growth Factors; Erythropoietin; Gene Expression Regulation, Neoplastic; Growth Substances; Humans; Liver Neoplasms; Lymphokines; Molecular Sequence Data; Neovascularization, Pathologic; Placenta Growth Factor; Platelet-Derived Growth Factor; Pregnancy Proteins; RNA, Messenger; RNA, Small Nuclear; Transforming Growth Factor beta; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1995
Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells.
    Pflugers Archiv : European journal of physiology, 1994, Volume: 429, Issue:2

    Topics: Animals; Cell Hypoxia; Cobalt; Cyclic AMP; Deferoxamine; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley

1994
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
    Blood, 1993, Dec-15, Volume: 82, Issue:12

    Topics: Base Sequence; Cell Hypoxia; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Oligonucleotide Probes; RNA, Neoplasm; Signal Transduction; Transcription Factors; Tumor Cells, Cultured

1993
Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing.
    European journal of biochemistry, 1995, Nov-15, Volume: 234, Issue:1

    Topics: Base Sequence; Biphenyl Compounds; Cobalt; Deferoxamine; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Onium Compounds; Oxygen; Transcription Factors; Tumor Cells, Cultured

1995
Generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators in relation to DNA damage and 2'-deoxyguanosine hydroxylation.
    Journal of toxicology and environmental health, 1996, Volume: 47, Issue:1

    Topics: Anserine; Azides; Chelating Agents; Chromatography, High Pressure Liquid; Cobalt; Deferoxamine; Deoxyguanosine; DNA Damage; Electron Spin Resonance Spectroscopy; Electrophoresis; Ethanol; Formates; Hydrogen Peroxide; Hydroxyl Radical; Hydroxylation; Mutagens; Oxidation-Reduction; Phenanthrolines; Reactive Oxygen Species; Sodium Azide; Spectrophotometry, Ultraviolet

1996
Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin.
    The Biochemical journal, 1996, Feb-01, Volume: 313 ( Pt 3)

    Topics: Base Sequence; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Energy Metabolism; Erythropoietin; Gene Expression Regulation; Glycolysis; HeLa Cells; Humans; Isoenzymes; Mitochondria; Molecular Sequence Data; Monosaccharide Transport Proteins; Oligonucleotide Probes; RNA, Messenger; Siderophores

1996
Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites.
    FEBS letters, 1996, Jun-03, Volume: 387, Issue:2-3

    Topics: Animals; Base Sequence; Binding Sites; Cell Hypoxia; Cell Line; Cobalt; Cycloheximide; Deferoxamine; Dithiothreitol; DNA Probes; DNA-Binding Proteins; Drosophila melanogaster; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Molecular Sequence Data; Nuclear Proteins; Phosphoglycerate Kinase; Phosphoric Monoester Hydrolases; Transcription Factors

1996
Hypoxia signalling in the control of erythropoietin gene expression in rat hepatocytes.
    Journal of cellular physiology, 1996, Volume: 168, Issue:2

    Topics: Animals; Catalase; Cell Hypoxia; Cells, Cultured; Cobalt; Cycloheximide; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression Regulation; Hydrogen Peroxide; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Liver; Male; Nuclear Proteins; Oxygen; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA; Signal Transduction; Transcription Factors

1996
Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.
    The Biochemical journal, 1997, Jan-01, Volume: 321 ( Pt 1)

    Topics: Animals; Antimutagenic Agents; Blood Gas Monitoring, Transcutaneous; Cobalt; Deferoxamine; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucokinase; Hydrogen Peroxide; Insulin; Liver; Male; Rats; Rats, Wistar; RNA, Messenger

1997
Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells.
    Kidney international, 1997, Volume: 51, Issue:2

    Topics: Cell Line; Cobalt; Cytochromes; Deferoxamine; Erythropoietin; Fluorescent Dyes; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Models, Molecular; NADPH Oxidases; Oxygen; Oxygen Consumption; Reactive Oxygen Species; Rhodamine 123; Rhodamines

1997
Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species.
    Kidney international, 1997, Volume: 51, Issue:2

    Topics: Cell Line; Cobalt; Deferoxamine; Erythropoietin; Humans; Hydrogen Peroxide; NADP; Reactive Oxygen Species; Signal Transduction

1997
Complex role of protein phosphorylation in gene activation by hypoxia.
    Kidney international, 1997, Volume: 51, Issue:2

    Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinase Kinases; Nuclear Proteins; Phosphorylation; Protein Kinase Inhibitors; Proteins; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Transcription Factors; Transcriptional Activation

1997
Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Animals; Antidotes; Calcium; Cattle; Cell Hypoxia; Cells, Cultured; Chlorides; Cobalt; Deferoxamine; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Ferrous Compounds; Gene Expression Regulation, Enzymologic; Glyceraldehyde-3-Phosphate Dehydrogenases; Heptanoates; Manganese Compounds; Nickel; Nitric Oxide; Nitroarginine; Nitroprusside; Oxidation-Reduction; RNA, Messenger; Up-Regulation; Zinc Compounds

1998
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.
    Nature, 1998, Mar-26, Volume: 392, Issue:6674

    Topics: Animals; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mutation; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
    Blood, 1998, Oct-01, Volume: 92, Issue:7

    Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; CHO Cells; Cobalt; COS Cells; Cricetinae; Cricetulus; Deferoxamine; DNA-Binding Proteins; Endothelial Growth Factors; Gene Expression Regulation; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; L-Lactate Dehydrogenase; Lymphokines; Mice; Mice, Inbred BALB C; Nuclear Proteins; Onium Compounds; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; RNA, Messenger; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1998
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
    Molecular pharmacology, 1998, Volume: 54, Issue:5

    Topics: Animals; Antimutagenic Agents; Base Sequence; Cell Hypoxia; Chelating Agents; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Erythropoietin; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Lymphokines; Mersalyl; Nuclear Proteins; Phosphopyruvate Hydratase; Rats; Receptor, IGF Type 1; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1998
Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase.
    Biochemical and biophysical research communications, 1998, Dec-30, Volume: 253, Issue:3

    Topics: Angiogenesis Inducing Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cobalt; Deferoxamine; Deoxyribose; Humans; Neovascularization, Pathologic; Oxygen; Ribosemonophosphates; Stereoisomerism; Thymidine Phosphorylase; Tumor Cells, Cultured

1998
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling.
    The Journal of biological chemistry, 1999, Mar-26, Volume: 274, Issue:13

    Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carbon Monoxide; Cell Hypoxia; Cell Line; Cobalt; Cyclic GMP; Cysteine; Deferoxamine; DNA-Binding Proteins; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Nitric Oxide; Nitroprusside; Nuclear Proteins; Oxygen; Receptors, Aryl Hydrocarbon; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transfection

1999
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.
    Molecular pharmacology, 1999, Volume: 56, Issue:1

    Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine

1999
Erythropoietin production: evidence for multiple oxygen sensing pathways.
    Annals of hematology, 1999, Volume: 78, Issue:6

    Topics: Chelating Agents; Cobalt; Deferoxamine; Erythropoietin; Humans; Iron Chelating Agents; Oxygen; Partial Pressure; Reactive Oxygen Species; Sulfhydryl Reagents; Tumor Cells, Cultured

1999
HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation.
    Nucleic acids research, 1999, Nov-01, Volume: 27, Issue:21

    Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA; DNA-Binding Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Iron Chelating Agents; Iron Deficiencies; Mice; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Receptors, Transferrin; Response Elements; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured

1999
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and ery
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Nov-15, Volume: 19, Issue:22

    Topics: Activating Transcription Factor 1; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Chelating Agents; Cobalt; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deferoxamine; DNA-Binding Proteins; Enzyme Induction; Erythropoietin; Fetus; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Glutathione; Glycolysis; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; L-Lactate Dehydrogenase; Mimosine; Neurons; Neuroprotective Agents; Nuclear Proteins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transcription Factors

1999
Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-stimulated Cyp1a1 promoter activity by hypoxic agents.
    Biochemical pharmacology, 2000, Jun-15, Volume: 59, Issue:12

    Topics: Animals; Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Chelating Agents; Cobalt; Cytochrome P-450 CYP1A1; Deferoxamine; Dose-Response Relationship, Drug; Drug Interactions; Ferrous Compounds; Gene Expression Regulation, Enzymologic; Genes, Reporter; Luciferases; Mice; Oxygen; Picolinic Acids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Time Factors

2000
Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells.
    Biochemical and biophysical research communications, 2000, May-19, Volume: 271, Issue:3

    Topics: Cell Hypoxia; Cells, Cultured; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Proteins; Muscle, Smooth, Vascular; Nuclear Proteins; Oxygen; RNA, Messenger; Transcription Factors

2000
Nitric oxide inhibits dioxin action for the stimulation of Cyp1a1 promoter activity.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:5

    Topics: Animals; Arginine; Cells, Cultured; Cobalt; Cytochrome P-450 CYP1A1; Deferoxamine; Dioxins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Lipopolysaccharides; Luciferases; Mice; Nitric Oxide; Nitroarginine; Nitroprusside; Picolinic Acids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Teratogens; Transfection

2000
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
    The Journal of biological chemistry, 2000, Aug-18, Volume: 275, Issue:33

    Topics: Androstadienes; Animals; Cell Line; Cell Nucleus; Chelating Agents; Cobalt; Cytosol; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex III; Electron Transport Complex IV; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Marine Toxins; Mitochondria; Mitochondria, Liver; Models, Biological; Nuclear Proteins; Oxazoles; Oxidation-Reduction; Oxygen; Paracoccus denitrificans; Rats; Reactive Oxygen Species; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured; Wortmannin

2000
Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: Animals; Arteries; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Blotting, Northern; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; Fluorescent Dyes; Heme; Hepatocytes; Immunoblotting; Male; Nucleic Acid Synthesis Inhibitors; Oxygen; Rats; Rats, Wistar; Rhodamine 123; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Veins

2000
Hypoxia promotes fibrogenesis in human renal fibroblasts.
    Kidney international, 2000, Volume: 58, Issue:6

    Topics: Actins; Antimutagenic Agents; Cell Division; Cell Hypoxia; Cell Size; Cell Survival; Cells, Cultured; Chelating Agents; Cobalt; Collagen; Collagenases; Culture Media, Conditioned; Deferoxamine; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Hypoxia; Kidney Cortex; Kidney Failure, Chronic; Oxygen; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1

2000
Accumulation of HIF-1alpha under the influence of nitric oxide.
    Blood, 2001, Feb-15, Volume: 97, Issue:4

    Topics: Animals; Benzoates; Cell Hypoxia; Cell Line; Cobalt; Coculture Techniques; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Guanylate Cyclase; Hydrazines; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Inflammation; Kidney Tubules, Proximal; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Nitroso Compounds; Nuclear Proteins; Oxadiazoles; Oxazines; S-Nitrosoglutathione; Spermine; Swine; Transcription Factors

2001
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms.
    The Journal of biological chemistry, 2001, Jun-01, Volume: 276, Issue:22

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Antimutagenic Agents; Apoptosis; Blotting, Northern; Cell Line; Cell Nucleus; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; DNA-Binding Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Inhibitor of Apoptosis Proteins; Kidney; Mice; Models, Biological; Nuclear Proteins; Oxidation-Reduction; Oxygen; Protein Synthesis Inhibitors; Proteins; Rats; Stem Cells; Transcription Factors; Transcription, Genetic; Up-Regulation

2001
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
    Science (New York, N.Y.), 2001, Apr-20, Volume: 292, Issue:5516

    Topics: Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Humans; Hydroxylation; Hydroxyproline; Ligases; Mass Spectrometry; Mice; Molecular Sequence Data; Oxygen; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitins; Von Hippel-Lindau Tumor Suppressor Protein

2001
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus.
    Blood, 2001, May-15, Volume: 97, Issue:10

    Topics: B-Lymphocytes; Blotting, Western; Capsid; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Glycoproteins; Herpesvirus 8, Human; Humans; Interleukin-6; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Viral Proteins; Virus Replication

2001
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Cycle Proteins; Cell Nucleus; Cobalt; Deferoxamine; DNA, Complementary; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Gene Library; Hypoxia; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Potassium Chloride; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; RNA, Messenger; Signal Transduction; Time Factors; Up-Regulation

2001
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane.
    FEBS letters, 2001, Dec-07, Volume: 509, Issue:2

    Topics: Anaerobiosis; Anesthetics, Inhalation; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Halothane; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured

2001
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
    The Journal of biological chemistry, 2002, Feb-22, Volume: 277, Issue:8

    Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

2002
Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells.
    Peptides, 2001, Volume: 22, Issue:11

    Topics: Adrenomedullin; Antimutagenic Agents; Cell Hypoxia; Cobalt; Deferoxamine; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Iron Chelating Agents; Membrane Proteins; Neuroblastoma; Peptides; Receptor Activity-Modifying Protein 2; Receptor Activity-Modifying Proteins; Receptors, Adrenomedullin; Receptors, Peptide; Tumor Cells, Cultured

2001
Haem metabolic aspects on nitric oxide formation in endotoxaemia.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:5

    Topics: Animals; Cell Line; Ceruloplasmin; Cobalt; Cytochrome P-450 Enzyme System; Deferoxamine; Endotoxemia; Endotoxins; Heme Oxygenase (Decyclizing); Iron; Lipopolysaccharides; Liver; Male; Mice; Microsomes; Nitric Oxide; Rats; Rats, Wistar

2001
Mechanisms of oxygen sensing in human trophoblast cells.
    Placenta, 2002, Volume: 23 Suppl A

    Topics: Adult; Chorionic Villi; Cobalt; Deferoxamine; Drug Combinations; Enzyme Inhibitors; Female; Ferrous Compounds; Hemeproteins; Humans; Hypoxia; Iron Chelating Agents; Mitochondria; Onium Compounds; Organ Culture Techniques; Oxygen; Oxygen Consumption; Pregnancy; Pregnancy Trimester, First; Rotenone; Trophoblasts; Uncoupling Agents

2002
Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia.
    The Biochemical journal, 2002, Jun-01, Volume: 364, Issue:Pt 2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Cobalt; Cyclic AMP Response Element-Binding Protein; Deferoxamine; DNA, Complementary; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hypoxia; Inhibitor of Apoptosis Proteins; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger; Sequence Deletion; Sequence Homology, Amino Acid; Sp1 Transcription Factor; Viral Proteins

2002
Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells.
    The Biochemical journal, 2002, Jun-01, Volume: 364, Issue:Pt 2

    Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Hypoxia; Cobalt; Deferoxamine; DNA Primers; Gene Expression Regulation; Humans; Liver; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 1; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor Tyrosine Kinase-like Orphan Receptors; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation

2002
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
    The Journal of biological chemistry, 2002, Oct-18, Volume: 277, Issue:42

    Topics: Amino Acids, Dicarboxylic; Animals; Chelating Agents; Cobalt; Deferoxamine; Fibroblasts; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron; Luciferases; Mice; Mice, Knockout; Proline; Protein Binding; Transcription Factors; Transfection

2002
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.
    The Journal of biological chemistry, 2003, Mar-14, Volume: 278, Issue:11

    Topics: Animals; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Blotting, Western; Cattle; Cell Line; Cobalt; Dactinomycin; Deferoxamine; Dimerization; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia; Interferon-gamma; Leucine Zippers; Luciferases; Membrane Proteins; Models, Genetic; Oxidative Stress; Oxygen; Promoter Regions, Genetic; Rats; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured

2003
Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
    The Journal of biological chemistry, 2003, May-02, Volume: 278, Issue:18

    Topics: Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; CHO Cells; Cobalt; Cricetinae; Deferoxamine; Glycine; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Ligases; Molecular Sequence Data; Rats; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2003
Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons.
    American journal of obstetrics and gynecology, 2003, Volume: 189, Issue:2

    Topics: Amino Acid Transport System ASC; Cell Line; Cobalt; Computer Systems; Deferoxamine; Down-Regulation; Female; Gene Products, env; Humans; Hypoxia; In Vitro Techniques; Iron Chelating Agents; Minor Histocompatibility Antigens; Placenta; Polymerase Chain Reaction; Pregnancy; Pregnancy Proteins; RNA, Messenger; Transcription, Genetic; Trophoblasts

2003
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.
    Blood, 2004, Mar-01, Volume: 103, Issue:5

    Topics: Activating Transcription Factor 4; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cobalt; Cysteine Endopeptidases; Deferoxamine; DNA-Binding Proteins; Electron Transport; Glucose; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Iron Chelating Agents; Mitochondria; Multienzyme Complexes; Mutation; Nuclear Proteins; Oxygen; Plasmids; Potassium Cyanide; Proteasome Endopeptidase Complex; Ribonucleases; RNA Interference; RNA, Messenger; Time Factors; Transcription Factor CHOP; Transcription Factors; Transfection; Tunicamycin

2004
Oxygen tension regulates the expression of a group of procollagen hydroxylases.
    European journal of biochemistry, 2003, Volume: 270, Issue:22

    Topics: Animals; Cells, Cultured; Cobalt; Deferoxamine; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Enzymologic; Hypoxia; Mice; Muscle, Smooth, Vascular; Oxygen; Procollagen; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Procollagen-Proline Dioxygenase; Rats; RNA, Messenger

2003
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.
    FEBS letters, 2003, Nov-20, Volume: 554, Issue:3

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glycine; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Mice; Mice, Inbred C57BL; Nuclear Proteins; Organ Specificity; Phosphofructokinase-2; Protein Biosynthesis; Proteins; Rats; RNA, Messenger; Transcription Factors

2003
Hypoxic regulation of angiopoietin-2 expression in endothelial cells.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Angiopoietin-2; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Cobalt; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Deferoxamine; Dinoprostone; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Iron Chelating Agents; Isoenzymes; Lactones; Membrane Proteins; Nuclear Proteins; Oligonucleotides, Antisense; Oxygen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Recombinant Proteins; RNA, Messenger; Sulfones; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

2004
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
    The Journal of biological chemistry, 2004, Apr-09, Volume: 279, Issue:15

    Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Nucleus; Cobalt; Deferoxamine; Dimerization; DNA; Epithelial Cells; Genes, Dominant; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Lung; Oxygen; Promoter Regions, Genetic; Protein Biosynthesis; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic

2004
Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.
    British journal of pharmacology, 2004, Volume: 141, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Cell Survival; Cobalt; Deferoxamine; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Neuroprotective Agents; Nuclear Proteins; Oligonucleotides; Rats; Transcription Factors

2004
Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.
    Archives of biochemistry and biophysics, 2004, Mar-15, Volume: 423, Issue:2

    Topics: Animals; Benzylamines; Brain; Calcium; Calcium Channel Blockers; Capillaries; Cell Hypoxia; Cell Line; Chelating Agents; Cobalt; Curcumin; Deferoxamine; Egtazic Acid; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Mice; Recombinant Proteins; RNA, Messenger; Sulfonamides; Triose-Phosphate Isomerase; Up-Regulation

2004
Possible involvement of pyruvate kinase in acquisition of tolerance to hypoxic stress in glial cells.
    Journal of neurochemistry, 2004, Volume: 91, Issue:1

    Topics: Antimutagenic Agents; Apoptosis; Astrocytoma; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Gel, Two-Dimensional; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Iron Chelating Agents; Mutagenesis; Neuroglia; Oxidative Stress; Pyruvate Kinase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, Protein; Stress, Physiological; Time Factors; Transcriptional Activation; Transfection; Vascular Endothelial Growth Factor A

2004
6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia.
    The Journal of biological chemistry, 2004, Dec-17, Volume: 279, Issue:51

    Topics: Animals; Binding Sites; Biotinylation; Blotting, Western; Cell Hypoxia; Cell Line; Cell Proliferation; Cobalt; Deferoxamine; Enhancer Elements, Genetic; Fructosediphosphates; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Glycine; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Luciferases; Mice; Models, Genetic; Oligonucleotides; Oxygen; Phosphofructokinase-2; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Software; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Up-Regulation

2004
Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.
    FEBS letters, 2004, Oct-08, Volume: 576, Issue:1-2

    Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glycine; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Male; Phosphofructokinase-2; Prostatic Neoplasms; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation

2004
Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells.
    Journal of neurochemistry, 2005, Volume: 93, Issue:3

    Topics: Animals; Astrocytes; Cell Death; Cell Line, Tumor; Cell Survival; Cobalt; Deferoxamine; DNA-Binding Proteins; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mimosine; Nitro Compounds; Nuclear Proteins; Propionates; Rats; Signal Transduction; Transcription Factors

2005
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:10

    Topics: Amino Acid Sequence; Cell Line; Cobalt; Deferoxamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Metals; Molecular Sequence Data; Nickel; Oxygen; Procollagen-Proline Dioxygenase; Serum Albumin, Bovine; Vascular Endothelial Growth Factor A; Zinc

2005
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells.
    Physiological genomics, 2005, Aug-11, Volume: 22, Issue:3

    Topics: Algorithms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Primers; Down-Regulation; Erythrocytes; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Liver Neoplasms; Nickel; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Transcription, Genetic; Up-Regulation

2005
Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
    International journal of oncology, 2005, Volume: 27, Issue:3

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cobalt; Deferoxamine; DNA-Binding Proteins; Flow Cytometry; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Necrosis; Nuclear Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors

2005
Hypoxia-simulating agents selectively stimulate arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells.
    Haematologica, 2005, Volume: 90, Issue:12

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Division; Cell Hypoxia; Cobalt; Deferoxamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Oncogene Proteins, Fusion; Oxides; Tretinoin; U937 Cells

2005
Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells.
    Haematologica, 2005, Volume: 90, Issue:12

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Bone Marrow; Cell Differentiation; Cell Division; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Drug Synergism; Gene Expression Regulation, Leukemic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Oncogene Proteins, Fusion; Oxides; Oxygen; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; U937 Cells

2005
Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:1

    Topics: Base Sequence; Caspase 3; Caspase 8; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Primers; Gene Dosage; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia; Membrane Potential, Mitochondrial; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitroprusside; Proto-Oncogene Proteins c-bcl-2; U937 Cells; Vanadates

2006
Thoracic Surgery Directors Association Award. Cobalt chloride pretreatment attenuates myocardial apoptosis after hypothermic circulatory arrest.
    The Annals of thoracic surgery, 2006, Volume: 81, Issue:6

    Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Awards and Prizes; bcl-2-Associated X Protein; Blotting, Western; Cardiopulmonary Bypass; Circulatory Arrest, Deep Hypothermia Induced; Cobalt; Deferoxamine; DNA Fragmentation; Gene Expression Regulation; Genes, bcl-2; Heart; Hypoxia; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Ischemic Preconditioning, Myocardial; Myocardium; Phosphorylation; Preanesthetic Medication; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Sus scrofa; Thoracic Surgery; United States

2006
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.
    Arthritis research & therapy, 2006, Volume: 8, Issue:4

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation

2006
Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.
    Free radical research, 2006, Volume: 40, Issue:8

    Topics: Cell Proliferation; Cobalt; Deferoxamine; DNA; Enzyme Inhibitors; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Kinetics; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Signal Transduction

2006
Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1.
    American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:1

    Topics: Actins; Cell Hypoxia; Cell Line, Tumor; Choriocarcinoma; Chorionic Villi; Cobalt; Cysteine Proteinase Inhibitors; Deferoxamine; Dose-Response Relationship, Drug; Female; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Oligonucleotides, Antisense; Pregnancy; Proteasome Endopeptidase Complex; Receptors, Transferrin; Time Factors; Tissue Culture Techniques; Trophoblasts; Up-Regulation

2007
Effect of chemical stabilizers of hypoxia-inducible factors on early lung development.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:3

    Topics: Amino Acids, Dicarboxylic; Animals; Chlorides; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Epithelial Cells; Ferric Compounds; Hypoxia-Inducible Factor 1; In Vitro Techniques; Indoles; Lung; Mice; Morphogenesis; Neovascularization, Physiologic; Pyrroles; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2

2007
HIF stabilizing agents: shotgun or scalpel?
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:3

    Topics: Amino Acids, Dicarboxylic; Animals; Cobalt; Deferoxamine; Female; Humans; Hypoxia-Inducible Factor 1; Lung; Mice; Neovascularization, Physiologic; Pregnancy; Premature Birth; Receptors, Vascular Endothelial Growth Factor

2007
Human skin keloid fibroblasts display bioenergetics of cancer cells.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:3

    Topics: Adenosine Triphosphate; Adolescent; Adult; Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Child, Preschool; Cobalt; Deferoxamine; Digitonin; Energy Metabolism; Female; Fibroblasts; Glucose; Humans; Hydrogen Peroxide; Infant; Keloid; Lactic Acid; Male; Middle Aged; Oligomycins; Siderophores; Skin Neoplasms; Uncoupling Agents

2008
DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension.
    The Journal of steroid biochemistry and molecular biology, 2008, Volume: 109, Issue:1-2

    Topics: Amino Acids, Dicarboxylic; Base Sequence; Cells, Cultured; Cobalt; Deferoxamine; Dehydroepiandrosterone; DNA Primers; Enzyme Inhibitors; Estradiol; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iron Chelating Agents; Models, Cardiovascular; Myocytes, Smooth Muscle; Procollagen-Proline Dioxygenase; Pulmonary Artery; Testosterone

2008
Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis.
    Sheng li xue bao : [Acta physiologica Sinica], 2008, Feb-25, Volume: 60, Issue:1

    Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Down-Regulation; E2F6 Transcription Factor; Myocytes, Cardiac; Rats

2008
Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats.
    Pediatric research, 2008, Volume: 63, Issue:6

    Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cobalt; Deferoxamine; Disease Models, Animal; Female; Hypoxia; Hypoxia-Ischemia, Brain; Male; Motor Skills; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Time Factors

2008
Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-alpha-mediated cell death.
    Journal of neuroscience research, 2008, Aug-15, Volume: 86, Issue:11

    Topics: Apoptosis; Blotting, Western; Cell Line; Cobalt; Deferoxamine; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microscopy, Fluorescence; Neuroprotective Agents; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tumor Necrosis Factor-alpha

2008
HIF and reactive oxygen species regulate oxidative phosphorylation in cancer.
    Carcinogenesis, 2008, Volume: 29, Issue:8

    Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Carrier Proteins; Cobalt; Cytoskeletal Proteins; Deferoxamine; Glycolysis; Homeostasis; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Chaperones; Neoplasms; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation; Reactive Oxygen Species; Respiratory Burst; Reverse Transcriptase Polymerase Chain Reaction

2008
Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine.
    Journal of neuroimmunology, 2008, Aug-30, Volume: 200, Issue:1-2

    Topics: Antimutagenic Agents; Bacteria; Cell Line, Transformed; Cell Wall; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Oligodendroglia; Siderophores; Teichoic Acids; Time Factors; Toll-Like Receptors

2008
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.
    The FEBS journal, 2008, Volume: 275, Issue:23

    Topics: Blotting, Northern; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Gene Expression Regulation, Enzymologic; Heme; Humans; Hydroxymethylbilane Synthase; Isoenzymes; Jurkat Cells; K562 Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Messenger; Tetrapyrroles; Uroporphyrinogen III Synthetase

2008
Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells.
    Neurotoxicity research, 2009, Volume: 15, Issue:4

    Topics: Actins; Analysis of Variance; Antifungal Agents; Cell Cycle; Cell Death; Cell Differentiation; Cell Line, Transformed; Cell Proliferation; Cell Survival; Ciclopirox; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Embryonic Stem Cells; Fetus; Humans; Hyperbaric Oxygenation; Hypoxia-Inducible Factor 1, alpha Subunit; Mesencephalon; Nerve Tissue Proteins; Pyridones; Siderophores

2009
Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo.
    Molecular cancer, 2009, Jun-09, Volume: 8

    Topics: Analysis of Variance; Animals; Biliverdine; Carbon Monoxide; Cell Line, Tumor; Cell Proliferation; Cobalt; Deferoxamine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Heme Oxygenase-1; Humans; Iron; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Siderophores; Zinc

2009
Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas.
    The FEBS journal, 2009, Volume: 276, Issue:24

    Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Cobalt; Colforsin; Deferoxamine; Disulfides; Gene Expression Regulation, Neoplastic; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indole Alkaloids; Male; Mice; Rats; Tumor Cells, Cultured

2009
Contribution of hypoxia-inducible factor-1α to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells.
    Animal science journal = Nihon chikusan Gakkaiho, 2011, Volume: 82, Issue:2

    Topics: Animals; Blotting, Western; Cattle; Cell Hypoxia; Cobalt; Deferoxamine; Female; Ferrous Compounds; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Luteal Cells; Oligodeoxyribonucleotides; Quaternary Ammonium Compounds; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Vascular Endothelial Growth Factor A

2011
Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:1

    Topics: Alkaline Phosphatase; Animals; Apoptosis; Aspirin; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cellular Microenvironment; Cobalt; Cyclooxygenase 2; Deferoxamine; Female; Fractures, Bone; Humans; Indomethacin; Mice; Osteoblasts; Poly(ADP-ribose) Polymerases; Sodium Salicylate; Sulindac

2012
Adipokine expression in brown and white adipocytes in response to hypoxia.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:5

    Topics: Adipocytes, White; Adipokines; Adipose Tissue, Brown; Animals; Antimutagenic Agents; Cells, Cultured; Cobalt; Deferoxamine; Hypoxia; Immunoblotting; Leptin; Mice; Siderophores

2012
Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts.
    Journal of periodontal research, 2012, Volume: 47, Issue:2

    Topics: Amino Acids, Dicarboxylic; Antimutagenic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Cobalt; Cyclin-Dependent Kinase Inhibitor p27; Deferoxamine; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Interleukin-1; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Ki-67 Antigen; Mimosine; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Procollagen-Proline Dioxygenase; Protein Kinase Inhibitors; Proteins; Siderophores; Vascular Endothelial Growth Factor A

2012
Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α.
    British journal of pharmacology, 2012, Volume: 167, Issue:7

    Topics: Amino Acids, Dicarboxylic; Cell Line; Cobalt; Deferoxamine; Down-Regulation; Eukaryotic Initiation Factor-2; HEK293 Cells; Humans; Hydrogen Sulfide; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit

2012
Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells.
    Journal of endodontics, 2012, Volume: 38, Issue:11

    Topics: Amino Acids, Dicarboxylic; Cells, Cultured; Cobalt; Deferoxamine; Dental Pulp; Dental Pulp Capping; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mimosine; Neovascularization, Physiologic; Procollagen-Proline Dioxygenase; Regeneration; Siderophores; Vascular Endothelial Growth Factor A

2012
Metabolic preconditioning of mammalian cells: mimetic agents for hypoxia lack fidelity in promoting phosphorylation of pyruvate dehydrogenase.
    Cell and tissue research, 2013, Volume: 351, Issue:1

    Topics: Amino Acids, Dicarboxylic; Animals; Blotting, Western; Cell Hypoxia; Cell Line; Cobalt; Deferoxamine; Gene Expression Regulation, Enzymologic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mammals; Mice; Phosphorylation; Pyruvate Dehydrogenase Complex; RNA, Messenger

2013
Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).
    Blood cells, molecules & diseases, 2013, Volume: 51, Issue:3

    Topics: Alternative Splicing; Base Sequence; Case-Control Studies; Cell Line; Cobalt; Deferoxamine; Ferrochelatase; Gene Expression Regulation; Gene Order; Gene Silencing; Genotype; Humans; Introns; Iron; Jumonji Domain-Containing Histone Demethylases; K562 Cells; Ketoglutaric Acids; Molecular Sequence Data; Mutation; Nuclear Proteins; Polymorphism, Single Nucleotide; Protoporphyria, Erythropoietic; Ribonucleoproteins; RNA Interference; RNA, Messenger; Sequence Alignment; Splicing Factor U2AF

2013
Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine.
    Journal of tissue engineering and regenerative medicine, 2016, Volume: 10, Issue:3

    Topics: Adipose Tissue; Antioxidants; Biomarkers; Cobalt; Culture Media, Conditioned; Deferoxamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neovascularization, Physiologic; Paracrine Communication; Stem Cells; Vascular Endothelial Growth Factor A

2016
The role of HIF in cobalt-induced ischemic tolerance.
    Neuroscience, 2013, Nov-12, Volume: 252

    Topics: Amino Acids, Dicarboxylic; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Cobalt; Deferoxamine; Erythropoietin; Hippocampus; Hypoxia-Inducible Factor 1; Immunohistochemistry; Ischemic Preconditioning; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Prolyl-Hydroxylase Inhibitors

2013
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
    The international journal of biochemistry & cell biology, 2013, Volume: 45, Issue:11

    Topics: Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cobalt; Deferoxamine; Erythropoietin; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Phosphoglycerate Kinase; Promoter Regions, Genetic; Propanolamines; Protein Binding; Pyrrolidines; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Upstream Stimulatory Factors

2013
Endocrine, biotransformation, and oxidative stress responses in salmon hepatocytes exposed to chemically induced hypoxia and perfluorooctane sulfonamide (PFOSA), given singly or in combination.
    Environmental science and pollution research international, 2015, Volume: 22, Issue:22

    Topics: Animals; Biotransformation; Cell Hypoxia; Cobalt; Deferoxamine; Drug Interactions; Endocrine System; Fluorocarbons; Hepatocytes; Oxidative Stress; Salmon; Sulfonamides; Water Pollutants, Chemical

2015
Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Cell Line, Tumor; Cobalt; Deferoxamine; Embolization, Therapeutic; Gadolinium; Humans; Nanoparticles; Neoplasms; Radiation-Sensitizing Agents; Titanium; Tumor Hypoxia

2017
Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors.
    Stem cells (Dayton, Ohio), 2018, Volume: 36, Issue:9

    Topics: Amino Acids, Dicarboxylic; Bone Marrow Cells; Cell Differentiation; Cell Hypoxia; Child; Chondrogenesis; Cobalt; Deferoxamine; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Mesenchymal Stem Cells

2018
Deferoxamine but Not Dimethyloxalylglycine, L-Mimosine, or Cobalt Dichloride Can Interfere with the MTT Assay.
    BioMed research international, 2018, Volume: 2018

    Topics: 3T3 Cells; Amino Acids, Dicarboxylic; Animals; Biocompatible Materials; Cell Line; Cell Survival; Cobalt; Deferoxamine; Dimethyl Sulfoxide; Mice; Mimosine; Tetrazolium Salts; Thiazoles

2018
The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue.
    Journal of biomaterials applications, 2019, Volume: 33, Issue:9

    Topics: Amino Acids, Dicarboxylic; Biocompatible Materials; Cell Hypoxia; Cells, Cultured; Clay; Cobalt; Deferoxamine; Drug Delivery Systems; Fibroblasts; Humans; Hydrogels; Mimosine; Periodontium; Tissue Scaffolds

2019
Hypoxic environment may enhance migration/penetration of endocrine resistant MCF7- derived breast cancer cells through monolayers of other non-invasive cancer cells in vitro.
    Scientific reports, 2020, 01-24, Volume: 10, Issue:1

    Topics: Basement Membrane; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Coculture Techniques; Deferoxamine; Epithelial-Mesenchymal Transition; Estrogens; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Receptors, Estrogen; RNA, Small Interfering; Sepharose

2020