cobalt has been researched along with cobamamide in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (8.33) | 18.7374 |
| 1990's | 13 (21.67) | 18.2507 |
| 2000's | 27 (45.00) | 29.6817 |
| 2010's | 13 (21.67) | 24.3611 |
| 2020's | 2 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Halpern, J | 1 |
| Ishida, A; Toraya, T | 1 |
| Bray, RC; Gutteridge, S; Hollaway, MR; Wallis, OC | 1 |
| Beatrix, B; Buckel, W; Kroll, F; Zelder, O | 1 |
| Diakun, GP; Evans, MC; Keep, NH; Leadlay, PF; Smith, GA | 1 |
| Abend, A; Kunz, M; Rétey, J; Such, P; Zhao, Y | 1 |
| Buckel, W; Zelder, O | 1 |
| Hitomi, T; Ichikawa, M; Ishida, A; Kobayashi, K; Kojima, S; Toraya, T | 1 |
| Bobik, TA; Lawrence, JG; Roth, JR | 1 |
| Ishida, A; Muguruma, H; Murakami, Y; Tobimatsu, T; Toraya, T; Yamada, S; Yamanishi, M; Yamauchi, J | 1 |
| Daikh, BE; Finke, RG; Fleming, PE | 1 |
| Ballou, DP; Marsh, EN | 1 |
| Lawrence, CC; Stubbe, J | 1 |
| Lawrence, CC; Licht, SS; Stubbe, J | 1 |
| Bothe, H; Buckel, W; Gruber, K; Jogl, G; Kratky, C; Reitzer, R; Wagner, UG | 1 |
| Abend, A; Bandarian, V; Nitsche, R; Reed, GH; Rétey, J; Stupperich, E | 1 |
| Dücker-Benfer, C; Hamza, MS; van Eldik, R | 1 |
| Brown, KL; Marques, HM | 1 |
| Brown, KL; Chen, G; Li, J; Zou, X | 1 |
| Kozlowski, PM | 1 |
| Frey, PA; Magnusson, OT | 1 |
| Escalante-Semerena, JC; Raux, E; Schubert, HL; Warren, MJ | 1 |
| Aida, T; Uyemura, M | 1 |
| Masuda, J; Morimoto, Y; Shibata, N; Toraya, T; Yasuoka, N | 1 |
| Brooks, AJ; Brunold, TC; Buan, NR; Stich, TA | 1 |
| GABBE, EE; HEINRICH, HC | 1 |
| EVANS, HJ; KLIEWER, M | 1 |
| Brown, KL; Chen, G; Marques, HM; Xia, Z; Zou, X | 1 |
| Banerjee, R; Brooks, AJ; Brunold, TC; Vlasie, M | 1 |
| Reed, GH | 1 |
| Banka, RR; Brown, KL; Marques, HM; Perry, CB; Zou, X | 1 |
| Banerjee, R; Fazliddinova, N; Mansoorabadi, SO; Padmakumar, R; Reed, GH; Vlasie, M | 1 |
| Warncke, K | 1 |
| Brunold, TC; Buan, NR; Escalante-Semerena, JC; Stich, TA | 1 |
| Jensen, KP; Ryde, U | 1 |
| Furlong, JM; Gruner, TM; Kelly, RJ; Sykes, AR | 1 |
| Brown, KL | 1 |
| Canfield, JM; Warncke, K | 1 |
| Frey, PA; Schwartz, PA | 1 |
| Deery, E; Lawrence, AD; McLean, KJ; Munro, AW; Pickersgill, RW; Rigby, SE; Warren, MJ | 1 |
| Wang, M; Warncke, K | 2 |
| Brunold, TC; Escalante-Semerena, JC; Mera, PE; Park, K | 1 |
| Escalante-Semerena, JC; Mera, PE; Rayment, I; St Maurice, M | 1 |
| Bucher, D; Durbeej, B; Radom, L; Sandala, GM; Smith, DM | 1 |
| Buchhaupt, M; Christen, P; Kaup, B; Kiefer, P; Schrader, J; Vorholt, JA | 1 |
| Robertson, WD; Wang, M; Warncke, K | 1 |
| Ramezani, M; Resmer, KL; White, RL | 1 |
| Hardman, SJ; Hay, S; Jones, AR; Scrutton, NS | 1 |
| Li, X; Morokuma, K; Pang, J; Scrutton, NS; Sutcliffe, MJ | 1 |
| Biedendieck, R; Deery, E; Howard, MJ; Lawrence, AD; Moore, SJ; Rigby, SE; Warren, MJ | 1 |
| Govender, PP; Marques, HM; Navizet, I; Perry, CB | 1 |
| Harvey, JN; Marsh, EN; Mulholland, AJ; Román-Meléndez, GD; von Glehn, P | 1 |
| Kepp, KP | 1 |
| Brown, KL; Brunold, TC; Conrad, KS; Jordan, CD | 1 |
| Brunold, TC; Escalante-Semerena, JC; Mera, PE; Moore, TC; Park, K | 1 |
| Garabato, BD; Jaworska, M; Kozlowski, PM; Lodowski, P | 1 |
| Bucher, D; Kozlowski, PM; Kumar, N | 1 |
| Banerjee, R; Gouda, H; Pillay, S | 1 |
| Shibata, N; Toraya, T | 1 |
7 review(s) available for cobalt and cobamamide
| Article | Year |
|---|---|
Cobalamin (coenzyme B12): synthesis and biological significance.
Topics: Biological Evolution; Biological Transport; Cobalt; Cobamides; Gene Expression Regulation, Bacterial; Intestines; Salmonella typhimurium; Species Specificity; Vitamin B 12 | 1996 |
The function of adenosylcobalamin in the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii.
Topics: Allosteric Regulation; Biological Evolution; Catalysis; Cobalt; Cobamides; Deoxyribonucleotides; Electron Spin Resonance Spectroscopy; Entropy; Free Radicals; Kinetics; Lactobacillus; Ligands; Mutagenesis, Site-Directed; Ribonucleotide Reductases | 1998 |
Quantum chemical modeling of Co--C bond activation in B(12)-dependent enzymes.
Topics: Cobalt; Cobamides; Models, Molecular; Quantum Theory; Vitamin B 12 | 2001 |
The biosynthesis of adenosylcobalamin (vitamin B12).
Topics: Bacteria; Catalysis; Cobalt; Cobamides; Cyclization; Genes, Bacterial; Methyltransferases; Molecular Structure; Nucleotidyltransferases; Protein Conformation; Uroporphyrinogens; Uroporphyrins; Vitamin B 12 | 2002 |
Radical mechanisms in adenosylcobalamin-dependent enzymes.
Topics: Binding Sites; Carbon; Cobalt; Cobamides; Free Radicals; Glutamic Acid; Glutarates; Hydrogen; Isotope Labeling; Kinetics; Models, Molecular; Ribonucleotide Reductases | 2004 |
The enzymatic activation of coenzyme B12.
Topics: Catalysis; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Enzyme Activation; Hot Temperature; Imidazoles; Kinetics; Lactobacillus leichmannii; Models, Chemical; Nitrogen; Ribonucleotide Reductases; Temperature | 2006 |
Structural Basis for the Activation of the Cobalt-Carbon Bond and Control of the Adenosyl Radical in Coenzyme B
Topics: Animals; Carbon; Catalysis; Cobalt; Cobamides; Models, Molecular | 2023 |
53 other study(ies) available for cobalt and cobamamide
| Article | Year |
|---|---|
Mechanisms of coenzyme B12-dependent rearrangements.
Topics: Carbon; Chemical Phenomena; Chemistry; Chemistry, Physical; Cobalt; Cobamides; Energy Metabolism; Free Radicals; Methylmalonyl-CoA Mutase | 1985 |
Acceleration of cleavage of the carbon-cobalt bond of sterically hindered alkylcobalamins by binding to apoprotein of diol dehydrase.
Topics: Allosteric Site; Apoproteins; Binding, Competitive; Carbon; Cobalt; Cobamides; In Vitro Techniques; Kinetics; Photolysis; Propanediol Dehydratase; Vitamin B 12 | 1988 |
The extents of formation of cobalt(II)-radical intermediates in the reactions with different substrates catalysed by the adenosylcobalamin-dependent enzyme ethanolamine ammonia-lyase.
Topics: Ammonia-Lyases; Catalysis; Chemical Phenomena; Chemistry; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Ethanolamine Ammonia-Lyase; Freezing; Spectrophotometry; Substrate Specificity | 1982 |
Coordination of a histidine residue of the protein-component S to the cobalt atom in coenzyme B12-dependent glutamate mutase from Clostridium cochlearium.
Topics: Amino Acid Isomerases; Bacterial Proteins; Benzimidazoles; Clostridium; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Escherichia coli; Histidine; Intramolecular Transferases; Recombinant Proteins | 1995 |
The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase.
Topics: Acyl Coenzyme A; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Methylmalonyl-CoA Mutase; Spectrophotometry, Ultraviolet; Spectrum Analysis; Substrate Specificity; Vitamin B 12 | 1993 |
Electron paramagnetic resonance studies of the methylmalonyl-CoA mutase reaction. Evidence for radical intermediates using natural and artificial substrates as well as the competitive inhibitor 3-carboxypropyl-CoA.
Topics: Binding, Competitive; Carbon; Cobalt; Cobamides; Coenzyme A; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen; Kinetics; Methylmalonyl-CoA Mutase; Propionibacterium; Substrate Specificity | 1994 |
On the role of two different cobalt(II) species in coenzyme B12-dependent 2-methyleneglutarate mutase from Clostridium barkeri.
Topics: Catalysis; Chromatography, High Pressure Liquid; Clostridium; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Intramolecular Transferases; Isomerases; Spectrophotometry, Ultraviolet | 1993 |
Importance of the nucleotide loop moiety coordinated to the cobalt atom of adenosylcobalamin for coenzymic function in the diol dehydrase reaction.
Topics: Binding Sites; Cobalt; Cobamides; Coenzymes; Corrinoids; Klebsiella; Nucleotides; Propanediol Dehydratase; Vitamin B 12 | 1993 |
Evidence for axial coordination of 5,6-dimethylbenzimidazole to the cobalt atom of adenosylcobalamin bound to diol dehydratase.
Topics: Benzimidazoles; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Propanediol Dehydratase; Structure-Activity Relationship | 1998 |
The coenzyme B12 derivative N1-methyl-5'-deoxyadenosylcobalamin: synthesis, characterization, stability towards dimroth rearrangement, and Co-C thermolysis product and kinetic studies.
Topics: Carbon; Cobalt; Cobamides; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Hot Temperature; Kinetics; Models, Chemical; Spin Labels | 1998 |
Coupling of cobalt-carbon bond homolysis and hydrogen atom abstraction in adenosylcobalamin-dependent glutamate mutase.
Topics: Carbon; Catalysis; Cobalt; Cobamides; Energy Transfer; Free Radicals; Hydrolysis; Intramolecular Transferases; Kinetics; N-Methylaspartate; Spectrophotometry; Substrate Specificity | 1998 |
Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis.
Topics: Allosteric Regulation; Allosteric Site; Calorimetry; Catalysis; Cobalt; Cobamides; Deoxyguanine Nucleotides; Entropy; Kinetics; Lactobacillus; Ribonucleotide Reductases; Thermodynamics | 1999 |
Glutamate mutase from Clostridium cochlearium: the structure of a coenzyme B12-dependent enzyme provides new mechanistic insights.
Topics: Clostridium; Cobalt; Cobamides; Intramolecular Transferases; Models, Molecular; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tartrates | 1999 |
Ethanolamine ammonia-lyase has a "base-on" binding mode for coenzyme B(12).
Topics: Benzimidazoles; Binding Sites; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Ethanolamine Ammonia-Lyase; Kinetics; Nitrogen Isotopes; Substrate Specificity | 1999 |
Ligand substitution behavior of a simple model for coenzyme B12.
Topics: Buffers; Cobalt; Cobamides; Hydrogen-Ion Concentration; Ligands; Models, Chemical; Spectrophotometry | 2000 |
Molecular modeling of the mechanochemical triggering mechanism for catalysis of carbon-cobalt bond homolysis in coenzyme B12.
Topics: Carbon; Catalysis; Chemical Phenomena; Chemistry, Physical; Cobalt; Cobamides; Molecular Conformation; Thermodynamics | 2001 |
Enzymatic activity of coenzyme B(12) derivatives with altered axial nucleotides: probing the mechanochemical triggering hypothesis in ribonucleotide reductase.
Topics: Adenine Nucleotides; Allosteric Regulation; Allosteric Site; Carbon; Catalysis; Cobalt; Cobamides; Escherichia coli; Kinetics; Lactobacillus; Models, Molecular; Molecular Conformation; Molecular Structure; Ribonucleotide Reductases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2001 |
Interactions of diol dehydrase and 3',4'-anhydroadenosylcobalamin: suicide inactivation by electron transfer.
Topics: Carbon; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cobalt; Cobamides; Deuterium; Dideoxyadenosine; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Propanediol Dehydratase; Salmonella typhimurium; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Vitamin B 12 | 2002 |
Steric control of organic transformation by a dendrimer cage: organocobalt dendrimer porphyrins as novel coenzyme B(12) mimics.
Topics: Alkylation; Alkynes; Cobalt; Cobamides; Models, Molecular; Molecular Conformation; Molecular Mimicry; Nuclear Magnetic Resonance, Biomolecular; Organometallic Compounds; Porphyrins; Propanols; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism | 2002 |
Substrate-induced conformational change of a coenzyme B12-dependent enzyme: crystal structure of the substrate-free form of diol dehydratase.
Topics: Binding Sites; Carbon; Cations, Monovalent; Cobalt; Cobamides; Crystallization; Crystallography, X-Ray; Klebsiella; Models, Molecular; Potassium; Propanediol Dehydratase; Protein Conformation; Substrate Specificity; Vitamin B 12 | 2002 |
Spectroscopic and computational studies of Co3+-corrinoids: spectral and electronic properties of the B12 cofactors and biologically relevant precursors.
Topics: Circular Dichroism; Cobalt; Cobamides; Corrinoids; Models, Molecular; Porphyrins; Spectrum Analysis, Raman; Vitamin B 12 | 2003 |
[METABOLIC BEHAVIOR OF INORGANIC COBALT AND OF VITAMIN B-12 AS WELL AS VITAMIN B-12 COENZYME STRUCTURE OF ORGANICALLY BOUND COBALT IN MAMMALS].
Topics: Animals; Cobalt; Cobalt Isotopes; Cobamides; Coenzymes; Corrinoids; Mammals; Metabolism; Research; Vitamin B 12; Vitamins | 1964 |
Effect of cobalt deficiency on the B12 coenzyme content of Rhizobium meliloti.
Topics: Cobalt; Cobamides; Coenzymes; Humans; Rhizobium; Sinorhizobium meliloti; Vitamin B 12 | 1962 |
Solution structure, enzymatic, and non-enzymatic reactivity of 3-isoadenosylcobalamin, a structural isomer of coenzyme B12 with surprising coenzymic activity.
Topics: Carbon; Cobalt; Cobamides; Hydrogen Bonding; Kinetics; Propanediol Dehydratase; Reverse Transcriptase Polymerase Chain Reaction; Solutions | 2004 |
Spectroscopic and computational studies on the adenosylcobalamin-dependent methylmalonyl-CoA mutase: evaluation of enzymatic contributions to Co-C bond activation in the Co3+ ground state.
Topics: Binding Sites; Circular Dichroism; Cobalt; Cobamides; Magnetic Resonance Spectroscopy; Methylmalonyl-CoA Mutase; Models, Chemical; Molecular Structure; Substrate Specificity | 2004 |
Solution structure and thermolysis of Cobeta-5'-deoxyadenosylimidazolylcobamide, a coenzyme B12 analogue with an imidazole axial nucleoside.
Topics: Algorithms; Cobalt; Cobamides; Imidazoles; Models, Molecular; Molecular Conformation; Molecular Structure; Nucleosides; Organometallic Compounds; Propionibacterium; Thermodynamics | 2004 |
Characterization of a succinyl-CoA radical-cob(II)alamin spin triplet intermediate in the reaction catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase.
Topics: Acyl Coenzyme A; Bacterial Proteins; Binding Sites; Carbon Isotopes; Catalysis; Cobalt; Cobamides; Coenzyme A Ligases; Deuterium; Electron Spin Resonance Spectroscopy; Free Radicals; Methylmalonyl-CoA Mutase; Models, Molecular; Spin Labels; Substrate Specificity; Vitamin B 12 | 2005 |
Characterization of the product radical structure in the Co(II)-product radical pair state of coenzyme B12-dependent ethanolamine deaminase by using three-pulse 2H ESEEM spectroscopy.
Topics: Binding Sites; Cobalt; Cobamides; Computer Simulation; Electron Spin Resonance Spectroscopy; Ethanolamine Ammonia-Lyase; Ethanolamines; Fourier Analysis; Free Radicals; Hydrogen Bonding; Models, Chemical; Protein Conformation; Salmonella typhimurium; Substrate Specificity; Thermodynamics | 2005 |
Spectroscopic and computational studies of the ATP:corrinoid adenosyltransferase (CobA) from Salmonella enterica: insights into the mechanism of adenosylcobalamin biosynthesis.
Topics: Alkyl and Aryl Transferases; Bacterial Proteins; Binding Sites; Circular Dichroism; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Salmonella enterica; Spectrum Analysis | 2005 |
How the Co-C bond is cleaved in coenzyme B12 enzymes: a theoretical study.
Topics: Carbon; Cobalt; Cobamides; Crystallography, X-Ray; Glutamic Acid; Hydrogen Bonding; Intramolecular Transferases; Models, Molecular; Molecular Conformation; Quantum Theory | 2005 |
Analysis of corrinoids in ovine tissues.
Topics: Animals; Chromatography, High Pressure Liquid; Cobalt; Cobamides; Corrinoids; Feces; Female; Gastrointestinal Contents; Humans; Hydroxocobalamin; Intestine, Small; Liver; Radioisotope Dilution Technique; Sheep; Vitamin B 12 | 2006 |
Active site reactant center geometry in the Co(II)-product radical pair state of coenzyme B12-dependent ethanolamine deaminase determined by using orientation-selection electron spin-echo envelope modulation spectroscopy.
Topics: Binding Sites; Biophysics; Chemistry, Physical; Cobalt; Cobamides; Electromagnetic Fields; Electron Spin Resonance Spectroscopy; Electrons; Escherichia coli; Ethanolamine Ammonia-Lyase; Hydrogen; Models, Chemical; Molecular Conformation; Salmonella typhimurium; Spectrum Analysis | 2005 |
Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin.
Topics: Carbon; Cobalt; Cobamides; Kinetics; Models, Molecular; Oxidation-Reduction; Oxygen; Potassium; Propanediol Dehydratase; Spectrophotometry | 2007 |
Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis.
Topics: Brucella melitensis; Cloning, Molecular; Cobalt; Cobamides; Corrinoids; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Ions; Kinetics; Models, Chemical; Molecular Conformation; Oxidoreductases; Structure-Activity Relationship; Thermodynamics; Vitamin B 12 | 2008 |
Kinetic and thermodynamic characterization of Co(II)-substrate radical pair formation in coenzyme B12-dependent ethanolamine ammonia-lyase in a cryosolvent system by using time-resolved, full-spectrum continuous-wave electron paramagnetic resonance spectr
Topics: Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Ethanolamine Ammonia-Lyase; Kinetics; Salmonella typhimurium; Thermodynamics | 2008 |
Kinetic and spectroscopic studies of the ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri: substrate specificity and insights into the mechanism of Co(II)corrinoid reduction.
Topics: Adenosine Triphosphate; Alkyl and Aryl Transferases; Bacterial Proteins; Binding Sites; Cobalt; Cobamides; Corrinoids; Kinetics; Limosilactobacillus reuteri; Oxidation-Reduction; Substrate Specificity; Thermodynamics | 2008 |
Residue Phe112 of the human-type corrinoid adenosyltransferase (PduO) enzyme of Lactobacillus reuteri is critical to the formation of the four-coordinate Co(II) corrinoid substrate and to the activity of the enzyme.
Topics: Alkyl and Aryl Transferases; Bacterial Proteins; Binding Sites; Cobalt; Cobamides; Corrinoids; Crystallography, X-Ray; Humans; Kinetics; Limosilactobacillus reuteri; Phenylalanine | 2009 |
On the importance of ribose orientation in the substrate activation of the coenzyme B12-dependent mutases.
Topics: Catalysis; Cobalt; Cobamides; Crystallography, X-Ray; Enzyme Activation; Hydrogen Bonding; Intramolecular Transferases; Ligands; Models, Molecular; Molecular Conformation; Protein Binding; Ribose | 2009 |
Metabolite profiling uncovers plasmid-induced cobalt limitation under methylotrophic growth conditions.
Topics: Acyl Coenzyme A; Bacterial Proteins; Biological Transport; Cell Proliferation; Cobalt; Cobamides; Gene Expression Regulation, Bacterial; Glyoxylates; Intramolecular Transferases; Isocitrate Lyase; Membrane Proteins; Methanol; Methylobacterium; Models, Biological; Plasmids | 2009 |
Characterization of protein contributions to cobalt-carbon bond cleavage catalysis in adenosylcobalamin-dependent ethanolamine ammonia-lyase by using photolysis in the ternary complex.
Topics: Carbon; Catalysis; Cobalt; Cobamides; Ethanolamine Ammonia-Lyase; Photolysis; Propanolamines | 2011 |
Glutamate racemization and catabolism in Fusobacterium varium.
Topics: Acetic Acid; Amino Acid Isomerases; Ammonia-Lyases; Bacterial Proteins; Butyrates; Carbon Isotopes; Chromatography, High Pressure Liquid; Cobalt; Cobamides; Fusobacterium; Glutamic Acid; Glutarates; Intramolecular Transferases; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; N-Methylaspartate; Stereoisomerism | 2011 |
Is there a dynamic protein contribution to the substrate trigger in coenzyme B12-dependent ethanolamine ammonia lyase?
Topics: Biocatalysis; Carbon; Cobalt; Cobamides; Ethanolamine Ammonia-Lyase; Magnetics; Photolysis; Static Electricity; Substrate Specificity | 2011 |
Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study.
Topics: Carbon; Cobalt; Cobamides; Intramolecular Transferases; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Stereoisomerism | 2012 |
Characterization of the enzyme CbiH60 involved in anaerobic ring contraction of the cobalamin (vitamin B12) biosynthetic pathway.
Topics: Bacillus megaterium; Biosynthetic Pathways; Catalysis; Cloning, Molecular; Cobalt; Cobamides; Dithiothreitol; Electron Spin Resonance Spectroscopy; Gene Expression Regulation, Enzymologic; Iron-Sulfur Proteins; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Models, Molecular; Molecular Conformation; Mutagenesis; Mutagenesis, Site-Directed; Oxygen; Recombinant Proteins; Solubility; Vitamin B 12 | 2013 |
DFT studies of trans and cis influences in the homolysis of the Co-C bond in models of the alkylcobalamins.
Topics: Carbon; Cobalt; Cobamides; Computer Simulation; Coordination Complexes; Ligands; Models, Molecular; Quantum Theory | 2013 |
Entropic origin of cobalt-carbon bond cleavage catalysis in adenosylcobalamin-dependent ethanolamine ammonia-lyase.
Topics: Biocatalysis; Carbon; Cobalt; Cobamides; Entropy; Ethanolamine Ammonia-Lyase; Kinetics; Models, Molecular; Propanolamines; Protein Conformation; Salmonella typhimurium | 2013 |
Role of active site residues in promoting cobalt-carbon bond homolysis in adenosylcobalamin-dependent mutases revealed through experiment and computation.
Topics: Cobalt; Cobamides; Glutamic Acid; Hydrogen Bonding; Intramolecular Transferases; Lysine; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation | 2014 |
Co-C dissociation of adenosylcobalamin (coenzyme B12): role of dispersion, induction effects, solvent polarity, and relativistic and thermal corrections.
Topics: Carbon; Cobalt; Cobamides; Models, Chemical; Quantum Theory; Solvents; Temperature | 2014 |
Spectroscopic and computational studies of cobalamin species with variable lower axial ligation: implications for the mechanism of Co-C bond activation by class I cobalamin-dependent isomerases.
Topics: Carbon; Circular Dichroism; Cobalt; Cobamides; Models, Molecular; Molecular Structure; Organometallic Compounds; Quantum Theory | 2015 |
Unprecedented Mechanism Employed by the Salmonella enterica EutT ATP:Co(I)rrinoid Adenosyltransferase Precludes Adenosylation of Incomplete Co(II)rrinoids.
Topics: Bacterial Proteins; Biocatalysis; Cobalt; Cobamides; Electron Spin Resonance Spectroscopy; Salmonella enterica; Transferases; Vitamin B 12 | 2015 |
Mechanism of Co-C photodissociation in adenosylcobalamin.
Topics: Cobalt; Cobamides; Ligands; Metals; Organometallic Compounds; Quantum Theory; Vitamin B 12 | 2016 |
Mechanistic Implications of Reductive Co-C Bond Cleavage in B
Topics: Binding Sites; Carbon; Catalysis; Cobalt; Cobamides; Computational Chemistry; Electron Transport; Methylmalonyl-CoA Mutase; Molecular Dynamics Simulation; Substrate Specificity; Vitamin B 12 | 2019 |
Redox-Linked Coordination Chemistry Directs Vitamin B
Topics: Cobalt; Cobamides; Coordination Complexes; Humans; Lysosomes; Methylmalonyl-CoA Mutase; Methyltransferases; Mitochondria; Oxidation-Reduction; Protein Structure, Tertiary; Vitamin B 12 | 2021 |