clozapine and pyrrolidine

clozapine has been researched along with pyrrolidine* in 1 studies

Other Studies

1 other study(ies) available for clozapine and pyrrolidine

Article	Year
The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones. European journal of medicinal chemistry, 2009, Volume: 44, Issue:2 A library of ethylene analogs of the previously described arylpiperazines with N-acylated amino acids was synthesized on SynPhase Lanterns and the library representatives were evaluated for their 5-HT(1A) and 5-HT(2A) receptor affinities. The obtained results were compared with those reported for compounds containing propylene and a butylene spacer and they revealed that 5-HT(1A) receptor affinity decreased proportionally with the length of the alkyl chain. Furthermore, the synthesized 3-cycloalkyl derivatives containing two methylene group spacers showed that the 3-position of pyrrolidine-2,5-dione preferred substituents of hydrophobic character. Topics: Amides; Amino Acids; Ethylenes; Humans; Hydrophobic and Hydrophilic Interactions; Piperazine; Piperazines; Protein Binding; Pyrrolidines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Small Molecule Libraries; Structure-Activity Relationship	2009

Article

Year

The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.

European journal of medicinal chemistry, 2009, Volume: 44, Issue:2

A library of ethylene analogs of the previously described arylpiperazines with N-acylated amino acids was synthesized on SynPhase Lanterns and the library representatives were evaluated for their 5-HT(1A) and 5-HT(2A) receptor affinities. The obtained results were compared with those reported for compounds containing propylene and a butylene spacer and they revealed that 5-HT(1A) receptor affinity decreased proportionally with the length of the alkyl chain. Furthermore, the synthesized 3-cycloalkyl derivatives containing two methylene group spacers showed that the 3-position of pyrrolidine-2,5-dione preferred substituents of hydrophobic character.

Topics: Amides; Amino Acids; Ethylenes; Humans; Hydrophobic and Hydrophilic Interactions; Piperazine; Piperazines; Protein Binding; Pyrrolidines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Small Molecule Libraries; Structure-Activity Relationship

2009