clozapine has been researched along with mezilamine* in 2 studies
2 other study(ies) available for clozapine and mezilamine
| Article | Year |
|---|---|
Interactions of clozapine, thioridazine, and mezilamine with oxotremorine on schedule-controlled responding.
The effects of clozapine (0.64-10 mg/kg IM), thioridazine (5-80 mg/kg IM), and mezilamine (0.1-10 mg/kg IM) were determined alone and the presence of 0.05 mg/kg oxotremorine on multiple fixed-ratio, fixed-interval responding in pigeons. All three drugs alone produced a dose-related decrease in responding. Thioridazine and mezilamine produced greater decreases in fixed-interval responding than fixed-ratio responding. Oxotremorine alone decreased responding to 10% of control. Clozapine and thioridazine produced a dose-related antagonism of the behavior-suppressing effects of oxotremorine with 5 mg/kg clozapine completely reversing the behavior-suppressing effects of oxotremorine. In contrast, mezilamine produced no antagonism of the behavior-suppressing effects of oxotremorine. It was concluded that the effects of clozapine on schedule-controlled responding in the pigeon are due to its anticholinergic effects, rather than to its antipsychotic-like effects. Thioridazine also has prominent anticholinergic effects, whereas mezilamine does not have anticholinergic effects. Topics: Animals; Antipsychotic Agents; Clozapine; Columbidae; Conditioning, Psychological; Dibenzazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Oxotremorine; Pyrimidines; Thioridazine; Time Factors | 1983 |
Hypokinesia in mice and catalepsy in rats elicited by morphine associated with antidopaminergic agents, including atypical neuroleptics.
The interaction of morphine with agents displaying antidopaminergic properties (low dose of apomorphine, alpha-methyl-p-tyrosine, the "classical" neuroleptic haloperidol as well as the "atypical" neuroleptics sulpiride, thioridazine, clozapine and mezilamine) has been studied both on locomotor activity in mice and catalepsy in rats. At the tested doses most of the drugs induced neither catalepsy nor akinesia, but when they were associated with morphine these effects were plainly observed. It is suggested that a hyperactivity of dopaminergic systems mask the cataleptic effect of morphine. Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Clozapine; Haloperidol; Humans; Male; Methyltyrosines; Mice; Morphine; Motor Activity; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Thioridazine | 1981 |