clozapine and flupenthixol-decanoate

The reduction of the frequency of rehospitalisation is important for improving the outcomes for patients with schizophrenia.. This study compares the rate of rehospitalisation between patients with antipsychotics in depot-form (n = 77) and oral second-generation antipsychotics (SGA) (n = 156).. Patients with antipsychotics in depot-form had lower risk of rehospitalisation than with SGAs in oral-form after 24 months (p = 0.027) and 36 months (p = 0.018) (Kaplan-Meyer survival analysis, Log-Rank). Long intervals between two hospitalisations were found for flupentixol depot and clozapine.. Antipsychotics in depot-form require and active and close outpatient treatment, which may account for long intervals between hospitalisation improved outcomes for patients with schizophrenia.

Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Clozapine; Delayed-Action Preparations; Female; Flupenthixol; Hospitals, Psychiatric; Humans; Male; Middle Aged; Patient Readmission; Retrospective Studies; Schizophrenia; Schizophrenic Psychology; Treatment Outcome