clozapine and betadex

clozapine has been researched along with betadex* in 2 studies

Other Studies

2 other study(ies) available for clozapine and betadex

Article	Year
Polyvinyl alcohol/citric acid/β-cyclodextrin/CuONP composite nanofibers as an effective and green absorbent for the simultaneous extraction of three antidepressant drugs in biological fluids prior to GC-FID analysis. Mikrochimica acta, 2023, 05-13, Volume: 190, Issue:6 Composite nanofibers, namely, polyvinyl alcohol (PVA), citric acid (CA), β-cyclodextrin (β-CD), and copper oxide nanoparticles (PVA/CA/β-cyclodextrin/CuO NPs), were developed as a novel, green, and efficient adsorbent in the pipette tip-micro-solid-phase extraction method (PT-µSPE), for the simultaneous extraction of three antidepressants drugs namely imipramine (IMP), citalopram (CIT), and clozapine (CLZ) in biological fluids before quantification by gas chromatography (GC-FID). Based on the obtained results from field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), the successful synthesis of composite nanofibers was approved. Due to the presence of β-cyclodextrins and CuO NPs rich of functional groups on their surface, the nanofibers have high extraction efficiency. Under the optimal conditions, the linear range for imipramine, citalopram, and clozapine was 0.1 to 1000.0 ng mL Topics: Antidepressive Agents; beta-Cyclodextrins; Chromatography, Gas; Citalopram; Clozapine; Imipramine; Nanofibers; Polyvinyl Alcohol; Spectroscopy, Fourier Transform Infrared	2023
Separation of antipsychotic drugs (clozapine, loxapine) and their metabolites by capillary zone electrophoresis. Journal of chromatography. A, 1999, Aug-20, Volume: 853, Issue:1-2 Two antipsychotic drugs (clozapine and loxapine) and six metabolites, N-demethylclozapine, clozapine N-oxide, N-demethylloxapine (amoxapine), 7-hydroxyloxapine, 8-hydroxyloxapine, 8-hydroxyamoxapine, were separated by capillary zone electrophoresis. Variation of pH and ionic strength of the acidic phosphate buffer (pH below 4) did not enable the separation of loxapine and one of its metabolites. Resolution of the single parent drugs and their metabolites was possible in background electrolytes (phosphate, pH 3.5, 60 mmol/l) containing either 0.2% (w/v) polyvinylpyrrolidone as replaceable pseudo-stationary phase, or 0.75 mmol/l beta-cyclodextrin added as complex-forming agent. Full separation of the mixture with baseline resolution of all analytes was obtained with a background electrolyte with heptakis-6-sulfato-beta-cyclodextrin added as negatively charged complexation agent with improved separation selectivity. Topics: Antipsychotic Agents; beta-Cyclodextrins; Clozapine; Cyclodextrins; Electrolytes; Electrophoresis, Capillary; gamma-Cyclodextrins; Hydrogen-Ion Concentration; Loxapine; Osmolar Concentration; Povidone	1999

Article

Year

Polyvinyl alcohol/citric acid/β-cyclodextrin/CuONP composite nanofibers as an effective and green absorbent for the simultaneous extraction of three antidepressant drugs in biological fluids prior to GC-FID analysis.

Mikrochimica acta, 2023, 05-13, Volume: 190, Issue:6

Composite nanofibers, namely, polyvinyl alcohol (PVA), citric acid (CA), β-cyclodextrin (β-CD), and copper oxide nanoparticles (PVA/CA/β-cyclodextrin/CuO NPs), were developed as a novel, green, and efficient adsorbent in the pipette tip-micro-solid-phase extraction method (PT-µSPE), for the simultaneous extraction of three antidepressants drugs namely imipramine (IMP), citalopram (CIT), and clozapine (CLZ) in biological fluids before quantification by gas chromatography (GC-FID). Based on the obtained results from field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), the successful synthesis of composite nanofibers was approved. Due to the presence of β-cyclodextrins and CuO NPs rich of functional groups on their surface, the nanofibers have high extraction efficiency. Under the optimal conditions, the linear range for imipramine, citalopram, and clozapine was 0.1 to 1000.0 ng mL

Topics: Antidepressive Agents; beta-Cyclodextrins; Chromatography, Gas; Citalopram; Clozapine; Imipramine; Nanofibers; Polyvinyl Alcohol; Spectroscopy, Fourier Transform Infrared

2023

Separation of antipsychotic drugs (clozapine, loxapine) and their metabolites by capillary zone electrophoresis.

Journal of chromatography. A, 1999, Aug-20, Volume: 853, Issue:1-2

Two antipsychotic drugs (clozapine and loxapine) and six metabolites, N-demethylclozapine, clozapine N-oxide, N-demethylloxapine (amoxapine), 7-hydroxyloxapine, 8-hydroxyloxapine, 8-hydroxyamoxapine, were separated by capillary zone electrophoresis. Variation of pH and ionic strength of the acidic phosphate buffer (pH below 4) did not enable the separation of loxapine and one of its metabolites. Resolution of the single parent drugs and their metabolites was possible in background electrolytes (phosphate, pH 3.5, 60 mmol/l) containing either 0.2% (w/v) polyvinylpyrrolidone as replaceable pseudo-stationary phase, or 0.75 mmol/l beta-cyclodextrin added as complex-forming agent. Full separation of the mixture with baseline resolution of all analytes was obtained with a background electrolyte with heptakis-6-sulfato-beta-cyclodextrin added as negatively charged complexation agent with improved separation selectivity.

Topics: Antipsychotic Agents; beta-Cyclodextrins; Clozapine; Cyclodextrins; Electrolytes; Electrophoresis, Capillary; gamma-Cyclodextrins; Hydrogen-Ion Concentration; Loxapine; Osmolar Concentration; Povidone

1999