clozapine has been researched along with 3-3a-dehydropyrazidol* in 1 studies
1 other study(ies) available for clozapine and 3-3a-dehydropyrazidol
| Article | Year |
|---|---|
The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABAA receptor binding.
The influence of pirlindole and dehydro-pirlindole on GABAA receptor binding and MAO-A activity was investigated in vitro. Inhibition of rat brain and human placenta MAO-A by both compounds was much more potent (with IC50 range 0.3-0.005 microM) than that of GABAA receptors. Pirlindole was inactive as a GABA antagonist. Dehydro-pirlindole exhibited selective blockade of GABA-A receptors with EC50 12 microM. Effects of both compounds on MAO-A activity were partially reversible. Data obtained suggest that in contrast to pirlindole dehydro-pirlindole may act not only as a MAO-A inhibitor but also as a potent GABAA receptor blocker. Topics: Animals; Antidepressive Agents; Benzodiazepinones; Brain; Carbazoles; Carbolines; Clozapine; Female; GABA Antagonists; Humans; Isoenzymes; Kinetics; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Placenta; Pregnancy; Rats; Receptors, GABA-A | 1998 |