Compounds > clotrimazole

clotrimazole and troleandomycin

clotrimazole has been researched along with troleandomycin in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19902 (15.38)18.7374
1990's2 (15.38)18.2507
2000's5 (38.46)29.6817
2010's4 (30.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beck, WT; Schuetz, EG; Schuetz, JD1
Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K1
Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K1
Pratim Roy, P; Roy, K1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Guzelian, PS; Hostetler, KA; Levin, W; Molowa, DT; Thomas, PE; Wrighton, SA1
Franklin, MR; Ritter, JK1
Cunninghame, ME; Evans, DC; Lake, BG; Price, RJ; Renwick, AB; Surry, D1
Bertholet, V; Bonnert, TP; de Longueville, F; Dos Santos-Mendes, S; Evrard, S; Jack, A; Meneses-Lorente, G; Pike, A; Remacle, J; Scott-Stevens, P; Sohal, B1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T1

Other Studies

13 other study(ies) available for clotrimazole and troleandomycin

ArticleYear
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
    Molecular pharmacology, 1996, Volume: 49, Issue:2

    Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil

1996
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
    Molecular pharmacology, 2002, Volume: 61, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine

2002
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine

2002
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents.
    Molecular pharmacology, 1989, Volume: 35, Issue:3

    Topics: Animals; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Imidazoles; Isoenzymes; Ketoconazole; Liver; Miconazole; Rats; Rats, Inbred Strains; RNA, Messenger; Troleandomycin

1989
Clotrimazole induction of cytochrome P-450: dose-differentiated isozyme induction.
    Molecular pharmacology, 1987, Volume: 31, Issue:2

    Topics: Aniline Hydroxylase; Animals; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Erythromycin; Glucuronosyltransferase; Imidazoles; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Rats; Troleandomycin

1987
Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver.
    Toxicology, 1998, Nov-02, Volume: 131, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clotrimazole; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Replication; Enzyme Induction; Female; Isoenzymes; Liver; Miconazole; Mitogens; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Troleandomycin

1998
An evaluation of a low-density DNA microarray using cytochrome P450 inducers.
    Chemical research in toxicology, 2003, Volume: 16, Issue:9

    Topics: Administration, Oral; Animals; Clofenapate; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Female; Forecasting; Gene Expression; Gene Expression Profiling; Genetic Markers; Hybridization, Genetic; Liver; Miconazole; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Troleandomycin

2003
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
    The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin

2005