cloricromen has been researched along with chromonar in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (29.23) | 18.7374 |
| 1990's | 31 (47.69) | 18.2507 |
| 2000's | 15 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mollace, V; Nisticó, G; Prosdocimi, M | 1 |
| Aliev, G; Cirillo, R; Prosdocimi, M; Salvatico, E | 1 |
| Cirillo, R; Ferreira, R; Grana, D; Llesuy, S; Milei, J; Prosdocimi, M | 1 |
| Altavilla, D; Calapai, G; Caputi, AP; Marciano, MC; Mazzaglia, G; Prosdocimi, M; Squadrito, F; Zingarelli, B | 1 |
| Bellato, P; Chen, S; Mariot, R; Moneti, G; Pieraccini, G; Zangirolami, L | 1 |
| Altavilla, D; Calapai, G; Campo, GM; Caputi, AP; Ioculano, M; Prosdocimi, M; Saitta, A; Squadrito, F; Zingarelli, B | 1 |
| Boveris, A; Ferreira, R; Grana, D; Llesuy, S; Milei, J; Prosdocimi, M | 1 |
| Calatroni, A; Campo, GM; Caputi, AP; Prosdocimi, M; Squadrito, F; Sturniolo, R; Vinci, R | 1 |
| Bazzoni, G; Dejana, E; Del Maschio, A; Prosdocimi, M; Zatta, A | 1 |
| Bazzoni, G; Chen, ZM; Dejana, E; Del Maschio, A; Prosdocimi, M; Zatta, A | 1 |
| Costantini, V; Goracci, G; Nenci, GG; Pistolesi, R; Porcellati, S; Prosdocimi, M; Stasi, M | 1 |
| Bertocchi, F; Breviario, F; Dejana, E; Ghezzi, P; Prosdocimi, M; Proserpio, P; Travagli, RA; Wang, JM | 1 |
| Banzatto, N; Finesso, M; Mariot, R; Prosdocimi, M; Tessari, F; Travagli, RA; Zatta, A | 1 |
| Altavilla, D; Caputi, AP; Prosdocimi, M; Squadrito, F; Sturniolo, R; Trimarchi, GR | 1 |
| Bertazzo, A; Galli, C; Petroni, A; Sarti, S | 1 |
| Falasca, A; Fiorentini, D; Hakim, G; Prosdocimi, M; Rossi, CA | 1 |
| Bertazzo, A; Colombo, C; Galli, C; Petroni, A; Sarti, S | 1 |
| Dal Bo Zanon, R; Fabris, F; Girolami, A; Luzzatto, G | 1 |
| Dejana, E; Prosdocimi, M; Zanetti, A; Zatta, A | 1 |
| Bianciardi, G; Di Perri, T; Franchi, M; Martelli, G; Toti, P; Vittoria, A; Weber, G | 1 |
| Dejana, E; Gorio, A; Prosdocimi, M; Zanetti, A; Zatta, A | 1 |
| Costantini, V; Goracci, G; Nenci, GG; Pistolesi, R; Porcellati, S; Porrovecchio, P; Prosdocimi, M | 1 |
| Bianciardi, G; Massari, P; Orlando, P; Toti, P; Weber, G | 1 |
| Aporti, F; Bertolino, M; Finesso, M; Gorio, A; Prosdocimi, M | 1 |
| Borghi, A; Galli, C; Petroni, A | 1 |
| de Gaetano, G; Dejana, E; Finesso, M; Gorio, A; Languino, LR; Prosdocimi, M; Tessari, F | 1 |
| Balconi, G; de Castellarnau, C; de Gaetano, G; Dejana, E; Pietra, A; Rotilio, D | 1 |
| Colli, S; Colombo, C; Galli, C; Petroni, A; Socini, A | 1 |
| Agradi, E; Galli, C; Petroni, A; Socini, A | 1 |
| Carnuccio, R; Di Rosa, M; Zingarelli, B | 1 |
| Aliev, GM; Novello, D; Prosdocimi, M; Salvatico, E | 1 |
| Altavilla, D; Campo, GM; Canale, P; Caputi, AP; Ioculano, M; Saitta, A; Squadrito, F; Squadrito, G | 1 |
| Calapai, G; Campo, GM; Caputi, AP; Marciano, MC; Rizzo, A; Squadrito, F | 1 |
| Alvino, S; Calà, A; Catalano, I; Davì, G; Giammaresi, C; Notarbartolo, A; Piva, S; Prosdocimi, M | 1 |
| Altavilla, D; Ammendolia, L; Campo, GM; Canale, P; Ferlito, M; Ioculano, M; Saitta, A; Squadrito, F; Squadrito, G; Zingarelli, B | 1 |
| Blandino, G; Cook, JA; Cusumano, V; Mancuso, G; Smith, E; Squadrito, F; Teti, G | 1 |
| Bernasconi, S; Dejana, E; Del Maschio, A; Tranchina, S | 1 |
| Beigelman, R; Cirillo, R; Ferreira, R; Grana, D; Milei, J | 1 |
| Goracci, G; Gresele, P; Nenci, GG; Pieretti, G; Porcellati, S; Prosdocimi, M; Quero, E; Stasi, M | 1 |
| Cirillo, R; Lidbury, PS; Vane, JR | 1 |
| Goracci, G; Gresele, P; Mezzasoma, AM; Nenci, GG; Prosdocimi, M; Quero, E; Ribaldi, E; Stasi, M | 1 |
| Altavilla, D; Campo, GM; Caputi, AP; Ioculano, M; Saitta, A; Squadrito, F; Squadrito, G | 1 |
| Altavilla, D; Calapai, G; Campo, GM; Caputi, AP; Ioculano, M; Miceli, A; Prosdocimi, M; Squadrito, F; Zingarelli, B | 1 |
| Aliev, G; Cirillo, R; Paro, M; Prosdocimi, M; Salvatico, E | 1 |
| Francescangeli, E; Goracci, G; Gresele, P; Mezzasoma, AM; Nenci, GG; Prosdocimi, M; Ribaldi, E | 1 |
| Altavilla, D; Bonaiuto, M; Campo, GM; Canale, P; Caputi, AP; Castaldo, M; Cinquegrani, M; Giordano, G; Saitta, A; Saitta, MN; Squadrito, F; Squadrito, G | 1 |
| Castellano, VP; Galaska, HJ; Kim, EJ; Murphy, BA; Royster, RL; Vinten-Johansen, J; Williams, MW; Zvara, DA | 1 |
| Deal, DD; Flye, CW; Groban, L; Ma, XL; Vernon, JC; Vinten-Johansen, J; Zvara, DA | 1 |
| Bevilacqua, C; Zatta, A | 1 |
| Di Sante, G; Gresele, P; Migliacci, R; Nenci, GG | 1 |
| Bevilaqua, C; Britti, D; Caputi, AP; Costantino, G; Cuzzocrea, S; De Sarro, A; Mazzon, E; Mazzullo, G | 1 |
| Bevilacqua, C; Binaglia, M; Corsini, E; Galli, CL; Lucchi, L; Marinovich, M; Monastra, G; Viviani, B | 1 |
| Bucolo, C; Maltese, A | 1 |
| Bucolo, C; Caputi, AP; Cuzzocrea, S; Mazzon, E | 1 |
| Campo, GM; Caputi, AP; Cuzzocrea, S; Fries, W; Giofré, MR; Lo Presti, MA; Longo, G; Mazzon, E; Sturiale, S; Sturniolo, GC | 1 |
| Brina, B; Forni, F; Leo, E; Vandelli, MA | 1 |
| Bucolo, C; Busà, B; Maltese, A; Maugeri, F; Pignatello, R; Puglisi, G | 1 |
| Di Meglio, P; Di Rosa, M; di Villa Bianca, Rd; Grassia, G; Ialenti, A; Ianaro, A; Maffia, P; Sorrentino, R | 1 |
| Allegri, G; Bertazzo, A; Caparrotta, L; Comai, S; Costa, CV; Ragazzi, E | 1 |
| Altavilla, D; Caputi, AP; Squadrito, F; Sturniolo, R | 1 |
| Britti, D; Cordasco, G; Crisafulli, C; Cuzzocrea, S; Maiere, D; Mazzon, E; Muià, C; Oteri, G; Zito, D | 1 |
| Bucolo, C; Maltese, A; Maugeri, F; Pignatello, R; Puglisi, G; Ricupero, N | 1 |
| Bucolo, C; Maltese, A; Maugeri, F; Pignatello, R | 1 |
| Bucolo, C; Maltese, A; Maugeri, F; Ward, KW | 1 |
| Bucolo, C; Cuzzocrea, S; Drago, F; Mazzon, E; Ward, KW | 1 |
2 trial(s) available for cloricromen and chromonar
| Article | Year |
|---|---|
Platelet aggregation, ATP release and cytoplasmic Ca2+ movement: the effects of cloricromene.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Adolescent; Adult; Calcium; Chromonar; Collagen; Cross-Over Studies; Cytoplasm; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors | 1994 |
Effect of cloricromene on intermittent claudication. A randomized, double-blind, placebo-controlled trial in patients treated with aspirin: effect on claudication distance and quality of life. CRAMPS Investigator Group. Cloricromene Randomized Arteriopath
Topics: Adult; Aged; Aspirin; Chromonar; Double-Blind Method; Drug Therapy, Combination; Emotions; Exercise Test; Female; Health Status; Humans; Intermittent Claudication; Male; Mental Health; Middle Aged; Pain; Placebos; Platelet Aggregation Inhibitors; Prospective Studies; Quality of Life; Social Behavior | 2000 |
63 other study(ies) available for cloricromen and chromonar
| Article | Year |
|---|---|
Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells.
Topics: Animals; Chromonar; Drug Synergism; Humans; Iloprost; Neutrophils; Nitroprusside; Platelet Aggregation; Rats | 1992 |
Effect of cloricromene during ischemia and reperfusion of rabbit hindlimb: evidence for an involvement of leukocytes in reperfusion-mediated tissue and vascular injury.
Topics: Animals; Blood Pressure; Chromonar; Creatine Kinase; Heart Rate; Hindlimb; Ibuprofen; Ischemia; L-Lactate Dehydrogenase; Leukocytes; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Peroxidase; Rabbits; Reperfusion Injury; Vascular Resistance | 1992 |
Effects of cloricromene on ischemia-reperfusion myocardial damage in the rabbit.
Topics: Animals; Chromonar; Coronary Circulation; Electrocardiography; Luminescent Measurements; Microscopy, Electron; Mitochondria, Heart; Mitochondrial Swelling; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rabbits | 1992 |
Cloricromene antagonizes antidipsogenic effects induced by endotoxin, but not by TNF alpha, in the rat.
Topics: Animals; Brain; Chromonar; Drinking; Endotoxins; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1992 |
Determination of the coumarin derivative cloricromene acid in rabbit plasma and platelets.
Topics: Animals; Blood Platelets; Chromatography, High Pressure Liquid; Chromonar; Indicators and Reagents; Male; Rabbits; Spectrometry, Mass, Fast Atom Bombardment | 1992 |
Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats.
Topics: Animals; Biological Assay; Blood Pressure; Chromonar; In Vitro Techniques; Leukocyte Count; Macrophages; Male; Peritoneal Cavity; Rats; Rats, Inbred Strains; Shock, Septic; Survival Rate; Tumor Necrosis Factor-alpha | 1992 |
Reduction of myocardial damage by cloricromene during ischemia-reperfusion in the rabbit.
Topics: Animals; Chromonar; Coronary Disease; Electrocardiography; Heart; In Vitro Techniques; Luminescent Measurements; Mice; Models, Biological; Myocardial Reperfusion Injury; Myocardium; Peroxides; Rabbits; Rats; Rats, Inbred Strains; tert-Butylhydroperoxide | 1992 |
Protective effect of cloricromene, a coumarine derivative, in hypovolemic hemorrhagic shock in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Chromonar; Electrocardiography; Male; Myocardial Depressant Factor; Rats; Rats, Inbred Strains; Shock, Hemorrhagic; Thromboxane B2 | 1991 |
Polymorphonuclear leukocyte-dependent modulation of platelet function: effect of cloricromene.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; beta-Thromboglobulin; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Chromonar; Cytoplasm; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Serine Endopeptidases | 1991 |
Cloricromene inhibits the activation of human platelets by ADP alone or in combination with adrenaline.
Topics: Adenosine Diphosphate; Aequorin; Calcium; Chromonar; Cytoplasm; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors | 1990 |
The coumarin derivative AD6 inhibits the release of arachidonic acid by interfering with phospholipase A2 activity in human platelets stimulated with thrombin.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chromonar; Coumarins; Diglycerides; Humans; Inositol; Phosphatidylcholines; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Plasmalogens; Thrombin | 1990 |
In vitro inhibition of human polymorphonuclear cell function by cloricromene.
Topics: Cell Adhesion; Cell Survival; Chemotaxis, Leukocyte; Chromium Radioisotopes; Chromonar; Coumarins; Endothelium, Vascular; Fibrinolytic Agents; Humans; In Vitro Techniques; Interleukin-1; Leukocyte Adherence Inhibition Test; Neutrophils; Superoxides; Time Factors; Vasodilator Agents | 1989 |
Molecular aspects of cloricromene (AD6) distribution in human platelets and its pharmacological effects.
Topics: Adenosine Diphosphate; Blood Platelets; Chemical Phenomena; Chemistry; Chromonar; Coumarins; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation Inhibitors | 1989 |
Cloricromene improves survival rate and peritoneal macrophage function in splanchnic artery occlusion shock in rats.
Topics: Animals; Chromonar; Coumarins; Dose-Response Relationship, Drug; In Vitro Techniques; Macrophage Activation; Male; Peritoneal Cavity; Rats; Rats, Inbred Strains; Shock; Thromboxane B2 | 1989 |
Arachidonic acid and its metabolites during cerebral ischemia and recirculation. Pharmacological interventions.
Topics: Animals; Arachidonic Acids; Brain; Chromonar; Fatty Acids, Unsaturated; Ischemic Attack, Transient; Rats; Reperfusion | 1989 |
Effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonylme tho xy coumarin) on cyclic nucleotide phosphodiesterases in human platelets.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Blood Platelets; Chromonar; Coumarins; Humans; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 1988 |
The carbochromene derivative AD6 reduces the TxB2/6-keto-PGF1 alpha ratio in cerebral cortex during hypoxia and recovery and leukotriene synthesis in brain tissue, in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Anaerobiosis; Animals; Cerebral Cortex; Chromonar; Coumarins; Hypoxia; In Vitro Techniques; Kinetics; Leukotriene B4; Lipoxygenase; Male; Rats; Rats, Inbred Strains; SRS-A; Thromboxane B2 | 1988 |
Lack of antiplatelet activity of the new coumarin derivative 8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy- carboxylmethoxycoumarin under in vivo conditions in man.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; beta-Thromboglobulin; Blood Platelets; Chromonar; Collagen; Coumarins; Humans; In Vitro Techniques; Platelet Aggregation | 1986 |
The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Aspirin; beta-Thromboglobulin; Blood Platelets; Chromonar; Coumarins; Drug Interactions; Epinephrine; Humans; In Vitro Techniques; Masoprocol; Platelet Activating Factor; Platelet Aggregation; Pyrazoles | 1986 |
Ultrastructural modifications of the platelet plasma membrane in vascular diseases and the effect of a carbochromen derivative as studied by freeze-fracture and computer measurement.
Topics: Administration, Oral; Adult; Aged; beta-Thromboglobulin; Blood Platelets; Cell Membrane; Chromonar; Computers; Coumarins; Female; Freeze Etching; Humans; Male; Middle Aged; Surface Properties; Vascular Diseases | 1986 |
Action of AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonylmet hox y coumarin) on human platelets in vitro.
Topics: Anticoagulants; beta-Thromboglobulin; Blood Platelets; Blood Proteins; Chromonar; Coumarins; Cyclic AMP; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Factor 4; Theophylline; Thromboxane B2 | 1986 |
AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth oxy coumarin) inhibits the release of arachidonic acid in human platelets stimulated by thrombin.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Chromonar; Coumarins; Diglycerides; Dose-Response Relationship, Drug; Humans; Phospholipids; Platelet Aggregation; Radioisotopes; Thrombin; Thromboxane B2 | 1987 |
Observations on the effects of some antiaggregating drugs on platelet specific protein discharge after a very weak stimulus.
Topics: Aminophylline; Aspirin; beta-Thromboglobulin; Blood Platelets; Cell Survival; Chromonar; Coumarins; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Factor 4; Platelet-Derived Growth Factor | 1985 |
The action of AD6 on experimental arrhythmias and on action potentials of cardiac fibers.
Topics: Aconitine; Action Potentials; Animals; Arrhythmias, Cardiac; Cats; Chromonar; Coumarins; Epinephrine; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Sinoatrial Node | 1986 |
Modification of brain vascular eicosanoids after pharmacological treatment and ischemia in the rat: drugs and brain vascular eicosanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Brain Ischemia; Cerebral Cortex; Chromonar; Eicosanoic Acids; Papaverine; Rats; Thromboxane B2; Thromboxanes; Vasodilator Agents | 1985 |
Inhibition by AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonyl methoxy coumarin) of platelet aggregation in dog stenosed coronary artery.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Chromonar; Collagen; Coronary Disease; Coumarins; Disease Models, Animal; Dogs; Epinephrine; Male; Platelet Activating Factor; Platelet Aggregation; Regional Blood Flow; Thromboxane B2 | 1985 |
AD 6, a coronary dilating agent, stimulates PGI2 production in rat aorta ex vivo and in human endothelial cells in culture.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Chromonar; Coumarins; Endothelium; Epoprostenol; Female; Humans; Male; Pregnancy; Prostaglandins; Rats; Umbilical Veins; Vasodilation | 1982 |
Effects of the coumarin derivative AD6 on platelet aggregation, platelet vessel wall interactions and 6 keto PGF1 alpha production in perfused aortas, in experimentally hypercholesterolaemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Aorta, Thoracic; Blood Platelets; Blood Vessels; Cholesterol; Chromonar; Coumarins; Epoprostenol; Hypercholesterolemia; In Vitro Techniques; Male; Platelet Aggregation; Rabbits; Thromboxane B2 | 1982 |
Effects of 8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy carboxyl methoxy coumarin (AD6) on aggregation, arachidonic acid metabolism and thromboxane B2 formation in human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acids; Blood Platelets; Chromonar; Collagen; Coumarins; Humans; In Vitro Techniques; Platelet Aggregation; Thromboxane B2 | 1980 |
Cloricromene inhibits the induction of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Cell Line; Chromonar; Depression, Chemical; Endotoxins; Enzyme Induction; In Vitro Techniques; Macrophages; Male; Mice; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Wistar; Shock, Septic | 1993 |
Functional depression of isolated perfused rat heart mediated by activated leukocytes: protective effect of cloricromene.
Topics: Animals; Chromonar; Coronary Vessels; Heart; Humans; Lymphocyte Activation; Male; Microscopy, Electron, Scanning Transmission; Myocardium; Neutrophils; Peroxidase; Rats; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1994 |
Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Cell Adhesion Molecules; Chromonar; E-Selectin; Leukocyte Count; Male; Rats; Rats, Sprague-Dawley; Shock; Splanchnic Circulation; Tumor Necrosis Factor-alpha | 1995 |
Multiple actions of the coumarine derivative cloricromene and its protective effects on ischemic brain injury.
Topics: Animals; Body Temperature; Brain Chemistry; Brain Edema; Brain Ischemia; Chromonar; Gerbillinae; Lipid Peroxidation; Male; Malondialdehyde; Motor Activity; Nerve Degeneration; Peroxidase; Platelet Aggregation Inhibitors; Reperfusion Injury | 1995 |
Participation of tumour necrosis factor and nitric oxide in the mediation of vascular dysfunction in splanchnic artery occlusion shock.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Chromonar; Cyclic AMP; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Phenylephrine; Rats; Rats, Sprague-Dawley; Shock; Splanchnic Circulation; Tumor Necrosis Factor-alpha | 1994 |
Efficacy of tumor necrosis factor alpha and eicosanoid inhibitors in experimental models of neonatal sepsis.
Topics: Acetophenones; Animals; Animals, Newborn; Bacterial Toxins; Chromonar; Eicosanoids; Endotoxins; Ibuprofen; Pentoxifylline; Rats; Rats, Sprague-Dawley; Sepsis; Streptococcal Infections; Streptococcus agalactiae; Tetrazoles; Tumor Necrosis Factor-alpha | 1994 |
Inhibition of human monocyte adhesion to endothelial cells by the coumarin derivative, cloricromene.
Topics: Antibodies, Monoclonal; Cell Adhesion; Chromonar; Depression, Chemical; Endothelium, Vascular; Female; Flow Cytometry; Fluorometry; Humans; In Vitro Techniques; Monocytes; Pregnancy; Receptors, Leukocyte-Adhesion; Umbilical Veins | 1994 |
Beneficial effects of cloricromene in ischemic reperfused myocardium.
Topics: Animals; Chromonar; Electrocardiography; Microscopy, Electron; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rabbits | 1994 |
Cloricromene inhibits G-protein-mediated activation of phospholipase A2 in human platelets.
Topics: Aluminum; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Chromonar; Cytosol; Enzyme Activation; Fluorine; GTP-Binding Proteins; Humans; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Thrombin | 1993 |
Dissociation of the anti-ischaemic effects of cloricromene from its anti-platelet activity.
Topics: Animals; Blood Pressure; Chromonar; Coronary Vessels; Electrocardiography; Heart Rate; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Peroxidase; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Ventricular Pressure | 1993 |
Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids.
Topics: Arachidonic Acid; Calcimycin; Chromonar; Dose-Response Relationship, Drug; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Membrane Lipids; Neutrophils; Phospholipids; SRS-A; Zymosan | 1993 |
[Tumor necrosis factor in myocardial ischemia and reperfusion].
Topics: Animals; Antibody Specificity; Chromonar; Creatine Kinase; Drug Evaluation, Preclinical; Immunization, Passive; Leukocyte Count; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Peroxidase; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 1993 |
The effect of cloricromene, a coumarine derivative, on leukocyte accumulation, myocardial necrosis and TNF-alpha production in myocardial ischaemia-reperfusion injury.
Topics: Analysis of Variance; Animals; Chromonar; Creatine Kinase; Leukocytes; Male; Myocardial Reperfusion Injury; Necrosis; Peroxidase; Rats; Rats, Sprague-Dawley; Survival Analysis; Tumor Necrosis Factor-alpha | 1993 |
Changes in vessel ultrastructure during ischemia and reperfusion of rabbit hindlimb: implications for therapeutic intervention.
Topics: Animals; Cell Adhesion; Chromonar; Creatine Kinase; Fibrinolytic Agents; Free Radicals; Hindlimb; Iliac Artery; L-Lactate Dehydrogenase; Leukocytes; Male; Microcirculation; Platelet Aggregation Inhibitors; Rabbits; Reperfusion Injury | 1993 |
Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation.
Topics: Acetyltransferases; Calcimycin; Chromonar; Diacylglycerol Cholinephosphotransferase; Enzyme Activation; Humans; In Vitro Techniques; Indicators and Reagents; Ionophores; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors | 1996 |
Effects of cloricromene on the levels of endothelin and on the microcirculatory function in peripheral atherosclerotic arteriopathies.
Topics: Aged; Analysis of Variance; Blood Pressure; Chromonar; Cold Temperature; Coronary Artery Disease; Echocardiography; Endothelins; Female; Femoral Artery; Heart Rate; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Regional Blood Flow; Vascular Resistance | 1996 |
Cloricromene reduces myocardial infarct size in rabbits when administered during the early reperfusion period.
Topics: Animals; Anticoagulants; Blood Pressure; Chromonar; Coumarins; Heart Rate; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Rabbits; Time Factors | 1997 |
Cloricromene reduces infarct size and alters postischaemic blood flow defects in dog myocardium.
Topics: Animals; Body Temperature; Chromonar; Coronary Circulation; Creatine Kinase; Dogs; Endothelium, Vascular; Female; Heart; Hemodynamics; Immune Adherence Reaction; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Neutrophils; Peroxidase; Platelet Aggregation Inhibitors | 1998 |
Differential inhibition of polymorphonuclear leucocyte functions by cloricromene.
Topics: Animals; Chromonar; Glucuronidase; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Rabbits; Superoxides | 1999 |
Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats.
Topics: Animals; Arthritis; Body Weight; Cattle; Chromonar; Collagen; Cyclooxygenase 2; Disease Progression; Enzyme Activation; Hindlimb; Interleukin-1; Isoenzymes; Male; Malondialdehyde; Nitric Oxide; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Radiography; Rats; Rats, Inbred Lew; Severity of Illness Index; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Cloricromene, a semi-synthetic coumarin derivative, inhibits tumor necrosis factor-alpha production at a pre-transcriptional level.
Topics: Animals; Chromonar; Dose-Response Relationship, Drug; Gene Expression Regulation; Lipopolysaccharides; Macrophages, Alveolar; NF-kappa B; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
Simultaneous determination of cloricromene and its active metabolite in rabbit aqueous humor by high-performance liquid chromatography.
Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Chromonar; Male; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2002 |
Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats.
Topics: Administration, Topical; Animals; Aqueous Humor; Chromonar; Ciliary Body; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Intercellular Adhesion Molecule-1; Iris; Lipopolysaccharides; Male; Nitrates; Nitrites; Ophthalmic Solutions; P-Selectin; Platelet Aggregation Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Salmonella; Tumor Necrosis Factor-alpha; Tyrosine; Uveitis, Anterior | 2003 |
A protective effect of the synthetic coumarine derivative Cloricromene against DNB-colitis in the rat.
Topics: Animals; Benzenesulfonates; Body Weight; Chemokine CXCL2; Chromonar; Colitis; Colon; Injections, Subcutaneous; Intestinal Mucosa; Male; Monokines; Organ Size; Peroxidase; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form.
Topics: Chromonar; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Lipids; Microscopy, Electron, Scanning; Nanotechnology; Polyesters; Solubility; Water | 2004 |
Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene.
Topics: Acrylic Resins; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Chromonar; Drug Administration Routes; Drug Delivery Systems; Drug Stability; Male; Nanotechnology; Particle Size; Platelet Aggregation Inhibitors; Rabbits; Solubility; Surface Properties; Technology, Pharmaceutical | 2004 |
Cloricromene in endotoxemia: role of NF-kappaB.
Topics: Animals; Aorta, Thoracic; Chromonar; Electrophoretic Mobility Shift Assay; Endotoxemia; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NF-kappa B; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phenylephrine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salmonella typhi; Tumor Necrosis Factor-alpha | 2004 |
Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits.
Topics: Animals; Cholesterol, Dietary; Chromonar; Diabetes Mellitus, Experimental; Free Radical Scavengers; Hyperlipidemias; Intestine, Small; Liver; Male; Niacin; Oxidation-Reduction; Oxygenases; Platelet Aggregation Inhibitors; Rabbits; Tryptophan | 2006 |
AD6, a coumarin derivative, and other pharmacological approaches to splanchnic artery occlusion (SAO) shock therapy.
Topics: Animals; Chromonar; Convulsive Therapy; Disease Models, Animal; Macrophages, Peritoneal; Male; Nimodipine; Phagocytosis; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Splanchnic Circulation | 1989 |
Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats.
Topics: Animals; Capillary Permeability; Chromonar; Male; Neutrophil Infiltration; Periodontitis; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene.
Topics: Acrylic Resins; Chemistry, Pharmaceutical; Chromonar; Drug Stability; Eye; Nanostructures; Particle Size; Solubility; Suspensions | 2006 |
Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.
Topics: Animals; Biological Availability; Brain; Chromonar; Drug Carriers; Lipids; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2006 |
Retinal and systemic pharmacokinetics of the anti-inflammatory drug cloricromene following oral administration in the rat and rabbit.
Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Chromonar; Dose-Response Relationship, Drug; Drug Stability; Ischemia; Male; Platelet Aggregation Inhibitors; Prodrugs; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Species Specificity; Tissue Distribution | 2007 |
Protective effects of a coumarin derivative in diabetic rats.
Topics: Animals; Antigens, CD; Blood-Retinal Barrier; Blotting, Western; Cadherins; Chromonar; Claudin-5; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Injections, Intraperitoneal; Intercellular Adhesion Molecule-1; Male; Membrane Proteins; Nitric Oxide Synthase Type III; Occludin; Phosphoproteins; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2009 |